bacteriophages

Summary

Summary: Viruses whose hosts are bacterial cells.

Top Publications

  1. Fischer S, Kittler S, Klein G, Glünder G. Microplate-test for the rapid determination of bacteriophage-susceptibility of Campylobacter isolates-development and validation. PLoS ONE. 2013;8:e53899 pubmed publisher
    ..test using 800 isolates of one Campylobacter strain with different degrees of susceptibility and four bacteriophages of the British phage typing scheme was developed and examined for its suitability...
  2. Swanson M, Reavy B, Makarova K, Cock P, Hopkins D, Torrance L, et al. Novel bacteriophages containing a genome of another bacteriophage within their genomes. PLoS ONE. 2012;7:e40683 pubmed publisher
    ..cereus Rock4-2. These findings suggest that MZTP02 can be shuttled between genomes of other bacteriophages and prophages, leading to the formation of chimeric genomes...
  3. Doria F, Napoli C, Costantini A, Berta G, Saiz J, Garcia Moruno E. Development of a new method for detection and identification of Oenococcus oeni bacteriophages based on endolysin gene sequence and randomly amplified polymorphic DNA. Appl Environ Microbiol. 2013;79:4799-805 pubmed publisher
    ..Oenococcus oeni is the main species responsible for MLF in most wines. As in other fermented foods, where bacteriophages represent a potential risk for the fermentative process, O...
  4. Zoued A, Durand E, Bebeacua C, Brunet Y, Douzi B, Cambillau C, et al. TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system. J Biol Chem. 2013;288:27031-41 pubmed publisher
    ..TssE, and TssB/C subunits are structurally and functionally related to components of the tail of contractile bacteriophages. This phage-like structure is thought to be anchored to the membrane by a trans-envelope complex composed of ..
  5. Iyer L, Zhang D, Burroughs A, Aravind L. Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res. 2013;41:7635-55 pubmed publisher
    ..Moreover, the current analysis suggests that bacteriophages and certain nucleo-cytoplasmic large DNA viruses contain an unexpectedly diverse range of DNA modification ..
  6. Swift B, Denton E, Mahendran S, Huxley J, Rees C. Development of a rapid phage-based method for the detection of viable Mycobacterium avium subsp. paratuberculosis in blood within 48 h. J Microbiol Methods. 2013;94:175-9 pubmed publisher
    ..Total assay time is 48 h and, unlike PCR-based detection tests, only viable cells are detected. A rapid method for detecting MAP in blood could further the understanding of disseminated infection in animals with Johne's disease...
  7. Soothill J. Use of bacteriophages in the treatment of Pseudomonas aeruginosa infections. Expert Rev Anti Infect Ther. 2013;11:909-15 pubmed publisher
    ..Phage has potential in the treatment of antibiotic resistant infection by P. aeruginosa. Hence, full scale clinical trials are needed. ..
  8. Jin M, Ye T, Zhang X. Roles of bacteriophage GVE2 endolysin in host lysis at high temperatures. Microbiology. 2013;159:1597-605 pubmed publisher
    ..insight into the mechanism of the lysis process of a thermophilic bacterium by its phage at high temperatures, which should be helpful in revealing the roles of thermophilic bacteriophages in the biosphere of deep-sea hydrothermal vents.
  9. Martinez A, Weldon S, Oliver K. Effects of parasitism on aphid nutritional and protective symbioses. Mol Ecol. 2014;23:1594-607 pubmed publisher
    ..Hamiltonella-based protection requires bacteriophages called APSEs with protection levels varying by strain and associated APSE. Endoparasitoids, including A...

More Information

Publications88

  1. Meader E, Mayer M, Steverding D, Carding S, Narbad A. Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system. Anaerobe. 2013;22:25-30 pubmed publisher
    ..The results demonstrate the potential of phage therapy, and highlight the limitations of using phages that have lysogenic capacity. ..
  2. Goh S, Hussain H, Chang B, Emmett W, Riley T, Mullany P. Phage ?C2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains. MBio. 2013;4:e00840-13 pubmed publisher
    ..This element is 13,008 bp in length and contains 17 putative open reading frames (ORFs). It could also be transferred at a lower frequency by filter mating...
  3. Barr J, Auro R, Furlan M, Whiteson K, Erb M, Pogliano J, et al. Bacteriophage adhering to mucus provide a non-host-derived immunity. Proc Natl Acad Sci U S A. 2013;110:10771-6 pubmed publisher
    ..The relationships shown here suggest a symbiotic relationship between phage and metazoan hosts that provides a previously unrecognized antimicrobial defense that actively protects mucosal surfaces. ..
  4. Dy R, Przybilski R, Semeijn K, Salmond G, Fineran P. A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism. Nucleic Acids Res. 2014;42:4590-605 pubmed publisher
    ..Our study reveals molecular insights into the regulation and function of the widespread bi-functional AbiE Abi-TA systems and the biochemical properties of both toxin and antitoxin proteins. ..
  5. Le S, He X, Tan Y, Huang G, Zhang L, Lux R, et al. Mapping the tail fiber as the receptor binding protein responsible for differential host specificity of Pseudomonas aeruginosa bacteriophages PaP1 and JG004. PLoS ONE. 2013;8:e68562 pubmed publisher
    ..Different RBPs can lead to differential host specificity. In many bacteriophages, such as Escherichia coli and Lactococcal phages, RBPs have been identified as the tail fiber or protruding ..
  6. Hammerling M, Ellefson J, Boutz D, Marcotte E, Ellington A, Barrick J. Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness. Nat Chem Biol. 2014;10:178-80 pubmed publisher
    ..Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial ..
  7. Murphy J, Royer B, Mahony J, Hoyles L, Heller K, Neve H, et al. Biodiversity of lactococcal bacteriophages isolated from 3 Gouda-type cheese-producing plants. J Dairy Sci. 2013;96:4945-57 pubmed publisher
    This study reports on the identification and characterization of bacteriophages isolated from cheese-production facilities that use undefined, mixed starter cultures...
  8. Essoh C, Blouin Y, Loukou G, Cablanmian A, Lathro S, Kutter E, et al. The susceptibility of Pseudomonas aeruginosa strains from cystic fibrosis patients to bacteriophages. PLoS ONE. 2013;8:e60575 pubmed publisher
    ..efficient therapeutic cocktails, the genetic diversity of the species and the spectrum of susceptibility to bacteriophages must be investigated...
  9. Wagner J, Maksimovic J, Farries G, Sim W, Bishop R, Cameron D, et al. Bacteriophages in gut samples from pediatric Crohn's disease patients: metagenomic analysis using 454 pyrosequencing. Inflamm Bowel Dis. 2013;19:1598-608 pubmed publisher
    ..The large abundance of phages in CD ileum tissue and CD gut wash sample suggests a role of phage in CD development. The role of phage dysbiosis in CD is currently unknown but opens up a new area of research. ..
  10. Hosseinidoust Z, van de ven T, Tufenkji N. Evolution of Pseudomonas aeruginosa virulence as a result of phage predation. Appl Environ Microbiol. 2013;79:6110-6 pubmed publisher
    The rapid increase in the emergence of antibiotic-resistant bacteria has attracted attention to bacteriophages for treating and preventing bacterial infections...
  11. Chan B, Abedon S, Loc Carrillo C. Phage cocktails and the future of phage therapy. Future Microbiol. 2013;8:769-83 pubmed publisher
    Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years ago...
  12. Hsu C, Lin T, Pan Y, Hsieh P, Wang J. Isolation of a bacteriophage specific for a new capsular type of Klebsiella pneumoniae and characterization of its polysaccharide depolymerase. PLoS ONE. 2013;8:e70092 pubmed publisher
    ..The capsular polysaccharide (CPS) is an important virulence factor of K. pneumoniae. With 78 capsular types discovered thus far, an association between capsular type and the pathogenicity of K. pneumoniae has been observed...
  13. Jaomanjaka F, Ballestra P, Dols Lafargue M, Le Marrec C. Expanding the diversity of oenococcal bacteriophages: insights into a novel group based on the integrase sequence. Int J Food Microbiol. 2013;166:331-40 pubmed publisher
    Temperate bacteriophages are a contributor of the genetic diversity in the lactic acid bacterium Oenococcus oeni...
  14. Muniesa M, Colomer Lluch M, Jofre J. Potential impact of environmental bacteriophages in spreading antibiotic resistance genes. Future Microbiol. 2013;8:739-51 pubmed publisher
    ..It is well accepted that bacteriophages are the most abundant entities in most environments, where they have been shown to be quite persistent...
  15. Alsteens D, Trabelsi H, Soumillion P, Dufrêne Y. Multiparametric atomic force microscopy imaging of single bacteriophages extruding from living bacteria. Nat Commun. 2013;4:2926 pubmed publisher
    ..report the use of advanced FD-based technology combined with biochemically sensitive tips to image filamentous bacteriophages extruding from living bacteria at unprecedented speed and resolution...
  16. Knez K, Noppe W, Geukens N, Janssen K, Spasic D, Heyligen J, et al. Affinity comparison of p3 and p8 peptide displaying bacteriophages using surface plasmon resonance. Anal Chem. 2013;85:10075-82 pubmed publisher
    ..Consequently, although p3 and p8-based phages both revealed exceptionally high affinities for eGFP, two p8 phages were found to have the highest affinity with dissociation constants (Kd) in the femtomolar range. ..
  17. Campagna C, Villion M, Labrie S, Duchaine C, Moineau S. Inactivation of dairy bacteriophages by commercial sanitizers and disinfectants. Int J Food Microbiol. 2014;171:41-7 pubmed publisher
    ..This study may help in the selection of appropriate chemicals for controlling phage contamination in industrial factories and research laboratories. ..
  18. Hoe S, Semler D, Goudie A, Lynch K, Matinkhoo S, Finlay W, et al. Respirable bacteriophages for the treatment of bacterial lung infections. J Aerosol Med Pulm Drug Deliv. 2013;26:317-35 pubmed publisher
    This review article discusses the development of respiratory therapeutics containing bacteriophages indicated for lung infections, specifically those that have become increasingly difficult to treat because of antibiotic resistance...
  19. Lee Y, Park J. Complete genome sequence of enterococcal bacteriophage SAP6. J Virol. 2012;86:5402-3 pubmed publisher
    ..To our knowledge, this study is the first to report the complete genome sequence of bacteriophage SAP6, which might be used as a therapeutic agent in combination with alternative antibiotics for multidrug-resistant E. faecalis. ..
  20. Zhang L, Zhao G, Ding X. Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination. Sci Rep. 2011;1:141 pubmed publisher
    ..This one-step approach was efficient and accurate, and able to join multiple DNA molecules in vitro in a defined order. Thus, it could have applications in constructing metabolic pathways and genetic networks. ..
  21. Owens J, Barton M, Heuzenroeder M. The isolation and characterization of Campylobacter jejuni bacteriophages from free range and indoor poultry. Vet Microbiol. 2013;162:144-50 pubmed publisher
    ..sixty one samples - primarily fresh chicken faeces - were processed to isolate wild type Campylobacter jejuni bacteriophages, via overlay agar methods using C. jejuni NCTC 12662...
  22. Kang I, Jang H, Cho J. Complete genome sequences of two Persicivirga bacteriophages, P12024S and P12024L. J Virol. 2012;86:8907-8 pubmed publisher
    The phylum Bacteroidetes is one of the major bacterial phyla in marine environments, where bacteriophages are highly abundant...
  23. García Heredia I, Martin Cuadrado A, Mojica F, Santos F, Mira A, Antón J, et al. Reconstructing viral genomes from the environment using fosmid clones: the case of haloviruses. PLoS ONE. 2012;7:e33802 pubmed publisher
    ..An example of transfer of a CRISPR cluster including repeats and spacers was accidentally found supporting the dynamic nature and frequent transfer of this peculiar prokaryotic mechanism of cell protection. ..
  24. Kim J, Dutta V, Elhanafi D, Lee S, Osborne J, Kathariou S. A novel restriction-modification system is responsible for temperature-dependent phage resistance in Listeria monocytogenes ECII. Appl Environ Microbiol. 2012;78:1995-2004 pubmed publisher
    ..Thus, temperature-dependent resistance of L. monocytogenes ECII to phage is mediated by temperature-dependent expression of the restriction endonuclease associated with a novel RM system (LmoH7) unique to this epidemic clone. ..
  25. Wang X, Li G, Ren Y, Ren X. Phages bearing affinity peptides to bovine rotavirus differentiate the virus from other viruses. PLoS ONE. 2011;6:e28667 pubmed publisher
    ..1 µg/ml of samples. The high sensitivity, specificity and low cross-reactivity for the phage-based ELISA were confirmed in receiver operating characteristics (ROC) analysis. ..
  26. Levin B, Moineau S, Bushman M, Barrangou R. The population and evolutionary dynamics of phage and bacteria with CRISPR-mediated immunity. PLoS Genet. 2013;9:e1003312 pubmed publisher
    ..We present evidence in support of these hypotheses and discuss the implications of these results for the ecology and (co)evolution of bacteria and phage. ..
  27. Mahony J, van Sinderen D. Structural aspects of the interaction of dairy phages with their host bacteria. Viruses. 2012;4:1410-24 pubmed publisher
    ..Furthermore, the potential of currently investigated dairy phages to in turn serve as model systems for this particular group of phages is discussed. ..
  28. Kęsik Szeloch A, Drulis Kawa Z, Weber Dabrowska B, Kassner J, Majkowska Skrobek G, Augustyniak D, et al. Characterising the biology of novel lytic bacteriophages infecting multidrug resistant Klebsiella pneumoniae. Virol J. 2013;10:100 pubmed publisher
    ..The increased incidence of antimicrobial resistance in these species has propelled the need for alternate/combination therapeutic regimens to aid clinical treatment. Bacteriophage therapy forms one of these alternate strategies...
  29. Weitz J, Poisot T, Meyer J, Flores C, Valverde S, Sullivan M, et al. Phage-bacteria infection networks. Trends Microbiol. 2013;21:82-91 pubmed publisher
    ..Here, we review emerging systems approaches that combine empirical data with rigorous theoretical analysis to study phage-bacterial interactions as networks rather than as coupled interactions in isolation. ..
  30. Smith D, Rooks D, Fogg P, Darby A, Thomson N, McCarthy A, et al. Comparative genomics of Shiga toxin encoding bacteriophages. BMC Genomics. 2012;13:311 pubmed publisher
    Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range...
  31. Hammerl J, Jäckel C, Reetz J, Hertwig S. The complete genome sequence of bacteriophage CP21 reveals modular shuffling in Campylobacter group II phages. J Virol. 2012;86:8896 pubmed publisher
    ..As in other group II phages, the CP21 genome is composed of large modules separated by long DNA repeat regions which obviously trigger recombination and modular shuffling. ..
  32. Zhang H, Bao H, Billington C, Hudson J, Wang R. Isolation and lytic activity of the Listeria bacteriophage endolysin LysZ5 against Listeria monocytogenes in soya milk. Food Microbiol. 2012;31:133-6 pubmed publisher
    ..Moreover, LysZ5 may also be useful for biocontrol in other ready-to-eat foods. ..
  33. Plagens A, Tjaden B, Hagemann A, Randau L, Hensel R. Characterization of the CRISPR/Cas subtype I-A system of the hyperthermophilic crenarchaeon Thermoproteus tenax. J Bacteriol. 2012;194:2491-500 pubmed publisher
    ..These data provide insights into the specialized mechanisms of an archaeal CRISPR/Cas system and allow selective functional analyses of Cas protein complexes in the future...
  34. Wu Z, Ren X, Yang L, Hu Y, Yang J, He G, et al. Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J Virol. 2012;86:10999-1012 pubmed
    ..These findings have expanded our understanding of the viromes of bats in China and hinted at the presence of a large variety of unknown mammalian viruses in many common bat species of mainland China...
  35. Sun C, Barrangou R, Thomas B, Horvath P, Fremaux C, Banfield J. Phage mutations in response to CRISPR diversification in a bacterial population. Environ Microbiol. 2013;15:463-70 pubmed publisher
  36. Adriaenssens E, Ackermann H, Anany H, Blasdel B, Connerton I, Goulding D, et al. A suggested new bacteriophage genus: "Viunalikevirus". Arch Virol. 2012;157:2035-46 pubmed
    ..These properties set the suggested genus apart from the recently ratified subfamily Tevenvirinae, although a significant evolutionary relationship can be observed...
  37. Tawil N, Sacher E, Mandeville R, Meunier M. Surface plasmon resonance detection of E. coli and methicillin-resistant S. aureus using bacteriophages. Biosens Bioelectron. 2012;37:24-9 pubmed publisher
    ..we describe the use of surface plasmon resonance (SPR) for the biodetection of pathogenic bacteria, using bacteriophages as the recognition elements. T4 bacteriophages were used to detect E...
  38. Metcalf J, Bordenstein S. The complexity of virus systems: the case of endosymbionts. Curr Opin Microbiol. 2012;15:546-52 pubmed publisher
    ..lifestyle, many endosymbionts, especially those that switch hosts, are rampant with mobile DNA and bacteriophages. One endosymbiont, Wolbachia pipientis, infects a vast number of arthropod and nematode species and often has ..
  39. Proença D, Fernandes S, Leandro C, Silva F, Santos S, Lopes F, et al. Phage endolysins with broad antimicrobial activity against Enterococcus faecalis clinical strains. Microb Drug Resist. 2012;18:322-32 pubmed publisher
    ..Lys170 was active against all tested E. faecalis VRE strains. The quasi specificity toward E. faecalis is discussed considering the nature of the enzymes' functional domains and the structure of the cell wall peptidoglycan. ..
  40. Stern A, Mick E, Tirosh I, Sagy O, Sorek R. CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome. Genome Res. 2012;22:1985-94 pubmed publisher
    ..Our finding of global sharing of gut phages is surprising in light of the extreme genetic diversity of phages found in other ecological niches. ..
  41. Niu Y, Stanford K, Kropinski A, Ackermann H, Johnson R, She Y, et al. Genomic, proteomic and physiological characterization of a T5-like bacteriophage for control of Shiga toxin-producing Escherichia coli O157:H7. PLoS ONE. 2012;7:e34585 pubmed publisher
    ..Phage AKFV33 is a unique, highly lytic STEC O157:H7-specific T5-like phage that may have considerable potential as a pre- and post-harvest biocontrol agent. ..
  42. Pereira C, Silva Y, Santos A, Cunha A, Gomes N, Almeida A. Bacteriophages with potential for inactivation of fish pathogenic bacteria: survival, host specificity and effect on bacterial community structure. Mar Drugs. 2011;9:2236-55 pubmed publisher
    ..The main objective of this work was to isolate bacteriophages with potential to inactivate fish pathogenic bacteria, without major effects on the structure of natural ..
  43. Overstreet C, Yuan T, Levin A, Kong C, Coroneus J, Weiss G. Self-made phage libraries with heterologous inserts in the Mtd of Bordetella bronchiseptica. Protein Eng Des Sel. 2012;25:145-51 pubmed publisher
    ..The reported experiments demonstrate the utility of the major tropism determinant protein of B.bronchiseptica as a natural scaffold for diverse, phage-constructed libraries with heterologous self-made phage libraries...
  44. Williams H. Phage-induced diversification improves host evolvability. BMC Evol Biol. 2013;13:17 pubmed publisher
    ..Also, resistance to phage often affects host fitness by pleiotropy (whereby mutations conferring resistance affect the function of other traits) and/or direct costs of resistance mechanisms...
  45. Selezska K, Kazmierczak M, Müsken M, Garbe J, Schobert M, Haussler S, et al. Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure. Environ Microbiol. 2012;14:1952-67 pubmed publisher
    ..aeruginosa. In summary, we conclude that the majority of the microevolutionary population dynamics of P.aeruginosa were shaped by the natural environment and not by the clinical habitat...
  46. Kraemer J, Erb M, Waddling C, Montabana E, Zehr E, Wang H, et al. A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell. Cell. 2012;149:1488-99 pubmed publisher
    ..Thus, we show that PhuZ assembles a spindle-like array that functions analogously to the microtubule-based spindles of eukaryotes...
  47. Kannoly S, Shao Y, Wang I. Rethinking the evolution of single-stranded RNA (ssRNA) bacteriophages based on genomic sequences and characterizations of two R-plasmid-dependent ssRNA phages, C-1 and Hgal1. J Bacteriol. 2012;194:5073-9 pubmed publisher
    We have sequenced and characterized two R-plasmid-dependent single-stranded RNA bacteriophages (RPD ssRNA phages), C-1 and Hagl1. Phage C-1 requires a conjugative plasmid of the IncC group, while Hgal1 requires the IncH group...
  48. Costa L, Faustino M, Neves M, Cunha A, Almeida A. Photodynamic inactivation of mammalian viruses and bacteriophages. Viruses. 2012;4:1034-74 pubmed publisher
    ..The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century...
  49. Borek A, Wilemska J, Izdebski R, Hryniewicz W, Sitkiewicz I. A new rapid and cost-effective method for detection of phages, ICEs and virulence factors encoded by Streptococcus pyogenes. Pol J Microbiol. 2011;60:187-201 pubmed
    ..We developed a novel, fast and cost effective system that can be used to detect GAS virulence factors. Moreover, this system may become an alternative and effective system to differentiate between GAS strains...
  50. Guo H, Tse L, Nieh A, Czornyj E, Williams S, Oukil S, et al. Target site recognition by a diversity-generating retroelement. PLoS Genet. 2011;7:e1002414 pubmed publisher
    ..In addition to furthering our understanding of DGR retrohoming, our results suggest that DGRs may provide unique tools for directed protein evolution via in vivo DNA diversification...
  51. Davidson A, Cardarelli L, Pell L, Radford D, Maxwell K. Long noncontractile tail machines of bacteriophages. Adv Exp Med Biol. 2012;726:115-42 pubmed publisher
    ..Finally, we speculate on the evolutionary advantages provided by long phage tails...
  52. Basler M, Pilhofer M, Henderson G, Jensen G, Mekalanos J. Type VI secretion requires a dynamic contractile phage tail-like structure. Nature. 2012;483:182-6 pubmed publisher
    ..These data support a model in which the contraction of the type VI secretion system sheath provides the energy needed to translocate proteins out of effector cells and into adjacent target cells...
  53. Moodley S, Maxwell K, Kanelis V. The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease. Protein Sci. 2012;21:809-18 pubmed publisher
    ..These studies define the biochemical function of gp74 as an HNH endonuclease and provide a platform for determining the role of gp74 in life cycle of the bacteriophage HK97...
  54. Lynch K, Stothard P, Dennis J. Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages. BMC Genomics. 2012;13:223 pubmed publisher
    Genomic analysis of bacteriophages infecting the Burkholderia cepacia complex (BCC) is an important preliminary step in the development of a phage therapy protocol for these opportunistic pathogens...
  55. Uchiyama J, Takeuchi H, Kato S, Takemura Uchiyama I, Ujihara T, Daibata M, et al. Complete genome sequences of two Helicobacter pylori bacteriophages isolated from Japanese patients. J Virol. 2012;86:11400-1 pubmed
    ..pylori. Here we report two complete genome sequences of H. pylori phages KHP30 and KHP40, which were released spontaneously from the most pathogenic East Asian-type isolates from Japanese patients...
  56. Drulis Kawa Z, Majkowska Skrobek G, Maciejewska B, Delattre A, Lavigne R. Learning from bacteriophages - advantages and limitations of phage and phage-encoded protein applications. Curr Protein Pept Sci. 2012;13:699-722 pubmed
    ..The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents...
  57. Kazaks A, Dislers A, Lipowsky G, Nikolajeva V, Tars K. Complete genome sequence of the Enterobacter cancerogenus bacteriophage Enc34. J Virol. 2012;86:11403-4 pubmed
    ..cancerogenus bacteriophage Enc34 was determined. The Enc34 genome is 60,364 bp in length and contains 80 open reading frames. To our knowledge, this is the first report of a bacteriophage infecting E. cancerogenus...
  58. Varga M, Kuntová L, Pantucek R, Mašlaňová I, Ruzickova V, Doskar J. Efficient transfer of antibiotic resistance plasmids by transduction within methicillin-resistant Staphylococcus aureus USA300 clone. FEMS Microbiol Lett. 2012;332:146-52 pubmed publisher
    ..In this study, we report efficient transduction of penicillinase and tetracycline resistance plasmids by bacteriophages ?80? and ?JB between clinical isolates belonging to the USA300 clone...
  59. Samson J, Moineau S. Bacteriophages in food fermentations: new frontiers in a continuous arms race. Annu Rev Food Sci Technol. 2013;4:347-68 pubmed publisher
    ..Recent discoveries related to antiphage systems that are changing our views on phage-host interactions are highlighted. Finally, future directions are also discussed...
  60. Zhu B, Tabor S, Raytcheva D, Hernandez A, King J, Richardson C. The RNA polymerase of marine cyanophage Syn5. J Biol Chem. 2013;288:3545-52 pubmed publisher
    ..Magnesium is required as a cofactor although some activity is observed with ferrous ions. Syn5 RNA polymerase is more efficient in utilizing low concentrations of ribonucleotides than T7 RNA polymerase...
  61. Lossi N, Manoli E, Forster A, Dajani R, Pape T, Freemont P, et al. The HsiB1C1 (TssB-TssC) complex of the Pseudomonas aeruginosa type VI secretion system forms a bacteriophage tail sheathlike structure. J Biol Chem. 2013;288:7536-48 pubmed publisher
    ..In conclusion, we provide further structural and mechanistic insights into the T6SS and show that a phage sheathlike structure is likely to be a conserved element across all T6SSs...
  62. Westra E, Swarts D, Staals R, Jore M, Brouns S, van der Oost J. The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity. Annu Rev Genet. 2012;46:311-39 pubmed publisher
    ..Because several excellent recent reviews cover all CRISPR subtypes, we mainly focus on a detailed description of the type I-E CRISPR/Cas system of the model bacterium Escherichia coli K12...
  63. Lee J, Domaille D, Cha J. Amplified protein detection and identification through DNA-conjugated M13 bacteriophage. ACS Nano. 2012;6:5621-6 pubmed publisher
    ..This saves precious resources by establishing a rapid, quantitative method to first screen for the presence of antigen followed by a highly specific typing assay if necessary...
  64. Zucca M, Scutera S, Savoia D. Novel avenues for Clostridium difficile infection drug discovery. Expert Opin Drug Discov. 2013;8:459-77 pubmed publisher
    ..As antibacterials currently used for primary C. difficile infections favor recurrences, new agents able to neutralize the bacterium without affecting the gut microbiota are badly needed...
  65. Harper D, Anderson J, Enright M. Phage therapy: delivering on the promise. Ther Deliv. 2011;2:935-47 pubmed
    b>Bacteriophages are viruses that infect and, in many cases, destroy their bacterial targets...
  66. Oliveira H, Melo L, Santos S, Nóbrega F, Ferreira E, Cerca N, et al. Molecular aspects and comparative genomics of bacteriophage endolysins. J Virol. 2013;87:4558-70 pubmed publisher
  67. Shin H, Lee J, Kim Y, Ryu S. Complete genome sequence of Cronobacter sakazakii bacteriophage CR3. J Virol. 2012;86:6367-8 pubmed publisher
    ..Here, we announce the genomic analysis results of the largest C. sakazakii phage known to date and report the major findings from the genome annotation...
  68. Swarts D, Mosterd C, van Passel M, Brouns S. CRISPR interference directs strand specific spacer acquisition. PLoS ONE. 2012;7:e35888 pubmed publisher
    ..In Escherichia coli, transcripts of these loci are cleaved into small RNAs and utilized by the Cascade complex to bind invader DNA, which is then likely degraded by Cas3 during CRISPR interference...
  69. Park J, Yun J, Lim J, Kang D, Ryu S. Characterization of an endolysin, LysBPS13, from a Bacillus cereus bacteriophage. FEMS Microbiol Lett. 2012;332:76-83 pubmed publisher
    Use of bacteriophages as biocontrol agents is a promising tool for controlling pathogenic bacteria including antibiotic-resistant bacteria...
  70. Bandara N, Jo J, Ryu S, Kim K. Bacteriophages BCP1-1 and BCP8-2 require divalent cations for efficient control of Bacillus cereus in fermented foods. Food Microbiol. 2012;31:9-16 pubmed publisher
    ..In this study, the usefulness of bacteriophages to eradicate B. cereus from fermented foods was investigated...
  71. Blower T, Evans T, Przybilski R, Fineran P, Salmond G. Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS Genet. 2012;8:e1003023 pubmed publisher
    ..Furthermore, the ?TE escape phages had evolved enhanced capacity to transduce replicons expressing ToxIN, demonstrating virus-mediated horizontal transfer of genetic altruism...
  72. Mo K, Li X, Li H, Low L, Quinn C, Boons G. Endolysins of Bacillus anthracis bacteriophages recognize unique carbohydrate epitopes of vegetative cell wall polysaccharides with high affinity and selectivity. J Am Chem Soc. 2012;134:15556-62 pubmed
    b>Bacteriophages express endolysins which are the enzymes that hydrolyze peptidoglycan resulting in cell lysis and release of bacteriophages...
  73. Richter C, Chang J, Fineran P. Function and regulation of clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR associated (Cas) systems. Viruses. 2012;4:2291-311 pubmed publisher
  74. Vaks L, Benhar I. In vivo characteristics of targeted drug-carrying filamentous bacteriophage nanomedicines. J Nanobiotechnology. 2011;9:58 pubmed publisher
    ..We have also shown that poorly water soluble drugs can be efficiently conjugated to the phage coat by applying hydrophilic aminoglycosides as branched solubility-enhancing linkers...
  75. Schmelcher M, Donovan D, Loessner M. Bacteriophage endolysins as novel antimicrobials. Future Microbiol. 2012;7:1147-71 pubmed publisher
    Endolysins are enzymes used by bacteriophages at the end of their replication cycle to degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release of progeny virions...
  76. Childs L, Held N, Young M, Whitaker R, Weitz J. Multiscale model of CRISPR-induced coevolutionary dynamics: diversification at the interface of Lamarck and Darwin. Evolution. 2012;66:2015-29 pubmed publisher
    ..We close by discussing how our explicit eco-evolutionary model of CRISPR immunity can help guide efforts to understand the drivers of diversity seen in microbial communities where CRISPR systems are active...
  77. Russell J, Weldon S, Smith A, Kim K, Hu Y, Łukasik P, et al. Uncovering symbiont-driven genetic diversity across North American pea aphids. Mol Ecol. 2013;22:2045-59 pubmed publisher
    ..pisum. Given the costs and benefits of these symbionts, it is likely that fluctuating selective forces play a role in the maintenance of this diversity...
  78. Karumidze N, Kusradze I, Rigvava S, Goderdzishvili M, Rajakumar K, Alavidze Z. Isolation and characterisation of lytic bacteriophages of Klebsiella pneumoniae and Klebsiella oxytoca. Curr Microbiol. 2013;66:251-8 pubmed publisher
    ..In this study, six lytic Klebsiella bacteriophages were isolated from sewage-contaminated river water in Georgia and characterised as phage therapy candidates...
  79. Huang S, Wang K, Jiao N, Chen F. Genome sequences of siphoviruses infecting marine Synechococcus unveil a diverse cyanophage group and extensive phage-host genetic exchanges. Environ Microbiol. 2012;14:540-58 pubmed publisher
    ..Metagenomic analysis based on the Global Ocean Sampling database showed that cyanosiphoviruses are present in relatively low abundance in the ocean surface water compared to cyanomyoviruses and cyanopodoviruses...