tumor virus infections

Summary

Summary: Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.

Top Publications

  1. van Aalderen M, Heutinck K, Huisman C, Ten Berge I. BK virus infection in transplant recipients: clinical manifestations, treatment options and the immune response. Neth J Med. 2012;70:172-83 pubmed
    ..Here, we will review the current knowledge on the structure and lifecycle of BKV, characteristics of the BKV-specific immune response, its clinical manifestations and the strengths and limitations of available treatments methods...
  2. van der Meijden E, Kazem S, Burgers M, Janssens R, Bouwes Bavinck J, de Melker H, et al. Seroprevalence of trichodysplasia spinulosa-associated polyomavirus. Emerg Infect Dis. 2011;17:1355-63 pubmed publisher
    ..In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age...
  3. Gaspar M, May J, Sukla S, Frederico B, Gill M, Smith C, et al. Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog. 2011;7:e1002346 pubmed publisher
    ..In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells...
  4. Major E. History and current concepts in the pathogenesis of PML. Cleve Clin J Med. 2011;78 Suppl 2:S3-7 pubmed publisher
    ..The emergence of PML in patients treated with natalizumab and other immune-altering agents supports this observation and provides new insights into the pathogenic mechanisms of JCV infection...
  5. Schrama D, Ugurel S, Becker J. Merkel cell carcinoma: recent insights and new treatment options. Curr Opin Oncol. 2012;24:141-9 pubmed publisher
    ..Although MCC is still regarded as a very rare tumor entity, its incidence is rapidly increasing. In this regard, the American Cancer Society estimated almost 1500 new cases in the United States in 2008...
  6. Bennett S, Broekema N, Imperiale M. BK polyomavirus: emerging pathogen. Microbes Infect. 2012;14:672-83 pubmed publisher
    ..In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols...
  7. Kusne S, Vilchez R, Zanwar P, Quiroz J, Mazur M, Heilman R, et al. Polyomavirus JC urinary shedding in kidney and liver transplant recipients associated with reduced creatinine clearance. J Infect Dis. 2012;206:875-80 pubmed publisher
    ..Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients...
  8. Delbue S, Ferraresso M, Elia F, Belingheri M, Carloni C, Signorini L, et al. Investigation of polyomaviruses replication in pediatric patients with nephropathy receiving rituximab. J Med Virol. 2012;84:1464-70 pubmed publisher
    ..No significant difference was found in the mean viral loads and in the viral molecular characterizations between the two groups. The polyomaviruses replication was not associated with rituximab therapy in children...
  9. Csoma E, Sapy T, Mészáros B, Gergely L. Novel human polyomaviruses in pregnancy: higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9. J Clin Virol. 2012;55:262-5 pubmed publisher
    ..There is lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU (WUPyV) and KI (KIPyV) during pregnancy...

More Information

Publications76

  1. Wojciechowski D, Chanda R, Chandran S, Lee B, Webber A, Macaraig M, et al. Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. Transplantation. 2012;94:1117-23 pubmed publisher
    ..A strategy of fluoroquinolone prophylaxis directed specifically against BKV has not been formally tested against a control group in kidney transplant recipients...
  2. Spurgeon M, Lambert P. Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology. 2013;435:118-30 pubmed publisher
  3. Harms P, Patel R, Verhaegen M, Giordano T, Nash K, Johnson C, et al. Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis. J Invest Dermatol. 2013;133:936-45 pubmed publisher
    ..Functional and clinical validation studies are needed to determine whether this tumor-suppressor pathway represents an avenue for targeted therapy...
  4. Feltkamp M, Kazem S, van der Meijden E, Lauber C, Gorbalenya A. From Stockholm to Malawi: recent developments in studying human polyomaviruses. J Gen Virol. 2013;94:482-96 pubmed publisher
    ..This review summarizes the recent developments in studying the novel human polyomaviruses, and touches upon several aspects of polyomavirus virology, pathogenicity, epidemiology and phylogeny...
  5. Kuypers J, Campbell A, Guthrie K, Wright N, Englund J, Corey L, et al. WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipients. Emerg Infect Dis. 2012;18:1580-8 pubmed publisher
    ..There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus reactivation, neutropenia, lymphopenia, hospitalization, or death...
  6. Conway C, Chalkley R, High A, Maclennan K, Berri S, Chengot P, et al. Next-generation sequencing for simultaneous determination of human papillomavirus load, subtype, and associated genomic copy number changes in tumors. J Mol Diagn. 2012;14:104-11 pubmed publisher
    ..Thus, the use of next-generation sequencing for the detection of HPV provides a multiplicity of data with clinical significance in a single test...
  7. Duncavage E, Pfeifer J. Human polyomaviruses 6 and 7 are not detectable in Merkel cell polyomavirus-negative Merkel cell carcinoma. J Cutan Pathol. 2011;38:790-6 pubmed publisher
    ..Consequently, we sought to determine if the presence of HPyV6 of HPyV7 could account for MCPyV-negative MCC...
  8. Iyer J, Afanasiev O, McClurkan C, Paulson K, Nagase K, Jing L, et al. Merkel cell polyomavirus-specific CD8? and CD4? T-cell responses identified in Merkel cell carcinomas and blood. Clin Cancer Res. 2011;17:6671-80 pubmed publisher
    ..We sought to characterize T-cell responses directed against viral proteins that drive this cancer as a step toward immunotherapy...
  9. Chen T, Mattila P, Jartti T, Ruuskanen O, Soderlund Venermo M, Hedman K. Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. J Infect Dis. 2011;204:1523-6 pubmed publisher
    ..TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years...
  10. Tan B, Busam K. Virus-associated Trichodysplasia spinulosa. Adv Anat Pathol. 2011;18:450-3 pubmed publisher
    ..The case of virus-associated TS exemplifies how a combination of astute clinicopathologic observation and a well-designed molecular genetic approach can provide insights into the pathogenesis of cutaneous disease...
  11. Dela Cruz F, Giannitti F, Li L, Woods L, Del Valle L, Delwart E, et al. Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United States. Emerg Infect Dis. 2013;19:77-84 pubmed publisher
    ..The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons...
  12. Kazem S, van der Meijden E, Kooijman S, Rosenberg A, Hughey L, Browning J, et al. Trichodysplasia spinulosa is characterized by active polyomavirus infection. J Clin Virol. 2012;53:225-30 pubmed publisher
    ..Seroepidemiological studies indicate that TSPyV is ubiquitous and latently infects 70% of the healthy individuals...
  13. Arora R, Chang Y, Moore P. MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol. 2012;2:489-98 pubmed publisher
    ..In four years, the cause, diagnosis and therapy for an intractable cancer has been changed due to the molecular discovery of MCV...
  14. Butel J. Patterns of polyomavirus SV40 infections and associated cancers in humans: a model. Curr Opin Virol. 2012;2:508-14 pubmed publisher
    ..This model can explain inconsistencies in the published literature of SV40 infections in humans and can guide the design of future studies...
  15. Duley A, Ploquin M, Eksmond U, Ammann C, Messer R, Myers L, et al. Negative impact of IFN-γ on early host immune responses to retroviral infection. J Immunol. 2012;189:2521-9 pubmed publisher
    ..Results from this model reveal that IFN-γ production can have detrimental effects on early adaptive immune responses and virus control. ..
  16. Saundh B, Baker R, Harris M, Welberry Smith M, Cherukuri A, Hale A. Early BK polyomavirus (BKV) reactivation in donor kidney is a risk factor for development of BKV-associated nephropathy. J Infect Dis. 2013;207:137-41 pubmed publisher
    ..Thus, early testing of urine samples from renal transplant recipients may identify those at risk for BKV-associated nephropathy...
  17. Nikitin P, Luftig M. The DNA damage response in viral-induced cellular transformation. Br J Cancer. 2012;106:429-35 pubmed publisher
    ..This review will focus on the interplay between oncogenic viruses and the DDR with respect to cellular checkpoint control and transformation...
  18. Trusch F, Klein M, Finsterbusch T, Kuhn J, Hofmann J, Ehlers B. Seroprevalence of human polyomavirus 9 and cross-reactivity to African green monkey-derived lymphotropic polyomavirus. J Gen Virol. 2012;93:698-705 pubmed publisher
  19. Gheit T, Munoz J, Levican J, Gonzalez C, Ampuero S, Parra B, et al. Merkel cell polyomavirus in non-small cell lung carcinomas from Chile. Exp Mol Pathol. 2012;93:162-6 pubmed publisher
    ..Thus a possible role of MCV in a very small subset of patients with lung cancer cannot be ruled out and warrants more investigation...
  20. Dalianis T, Hirsch H. Human polyomaviruses in disease and cancer. Virology. 2013;437:63-72 pubmed publisher
    ..The discovery of the new HPyVs has revived interest in the Polyomaviridae and their association to human disease and cancer. In this review, we summarize knowledge about this expanding family of human pathogens...
  21. Rollison D, Giuliano A, Messina J, Fenske N, Cherpelis B, Sondak V, et al. Case-control study of Merkel cell polyomavirus infection and cutaneous squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2012;21:74-81 pubmed publisher
    ..Merkel cell polyomavirus (MCV) DNA has been reported in 0% to 25% of squamous cell carcinomas (SCC) occurring in immunocompetent individuals. We conducted the first serologic case-control study of MCV and SCC...
  22. Rodig S, Cheng J, Wardzala J, DoRosario A, Scanlon J, Laga A, et al. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012;122:4645-53 pubmed publisher
    ..These results indicate that MCPyV is present in MCC tumors more frequently than previously reported and that mutations in TP53 tend to occur in MCC tumors that fail to express MCPyV large T antigen...
  23. Viscidi R, Rollison D, Sondak V, Silver B, Messina J, Giuliano A, et al. Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus. Clin Vaccine Immunol. 2011;18:1737-43 pubmed publisher
    ..In agreement with results from other studies, we found an association between MCPyV seropositivity and MCC, and higher levels of serum MCPyV capsid antibodies in MCC patients than in controls...
  24. Imajoh M, Hashida Y, Taniguchi A, Kamioka M, Daibata M. Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases. J Hematol Oncol. 2012;5:25 pubmed publisher
    ..To increase the volume of relevant data, this study investigated the prevalence and DNA loads of MCPyV and human polyomavirus 9 (HPyV9), another lymphotropic polyomavirus, in Japanese CLL cases...
  25. Nicol J, Touze A, Robinot R, Arnold F, Mazzoni E, Tognon M, et al. Seroprevalence and cross-reactivity of human polyomavirus 9. Emerg Infect Dis. 2012;18:1329-32 pubmed publisher
    ..Identification of human polyomavirus 9 (HPyV9) led us to compare the seroprevalence and cross-reactivity of LPyV and HpyV9. Results could indicate that humans who have antibodies against LPyV are infected by HPyV9...
  26. Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, et al. Human polyomavirus related to African green monkey lymphotropic polyomavirus. Emerg Infect Dis. 2011;17:1364-70 pubmed publisher
    ..These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders...
  27. Tolstov Y, Knauer A, Chen J, Kensler T, Kingsley L, Moore P, et al. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis. 2011;17:1371-80 pubmed publisher
    ..In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations...
  28. Jung H, Choi Y, Choi J, Roh J, Pyon J, Woo K, et al. Detection of Merkel cell polyomavirus in Merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry. Histol Histopathol. 2011;26:1231-41 pubmed publisher
    ..Considering both PCR and IHC results, MCPyV was detected in all MCCs tested. The presence of MCPyV in all MCC cases tested and in some SCC cases suggests that MCPyV may be involved in the malignant transformation...
  29. Imajoh M, Hashida Y, Nemoto Y, Oguri H, Maeda N, Furihata M, et al. Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients. Virol J. 2012;9:154 pubmed publisher
    ..In this study, we aimed to clarify the possible presence of MCPyV in cervical SCCs from Japanese patients. Cervical adenocarcinomas (ACs) were also studied...
  30. Van Ghelue M, Khan M, Ehlers B, Moens U. Genome analysis of the new human polyomaviruses. Rev Med Virol. 2012;22:354-77 pubmed publisher
  31. Orlova N, Wang F, Fogg M. Persistent infection drives the development of CD8+ T cells specific for late lytic infection antigens in lymphocryptovirus-infected macaques and Epstein-Barr virus-infected humans. J Virol. 2011;85:12821-4 pubmed publisher
    ..Thus, viral major histocompatibility complex class I (MHCI) immune evasion genes expressed during lytic LCV infection do not prevent L-specific CD8(+) T cell development over time during persistent infection...
  32. Sood P, Senanayake S, Sujeet K, Medipalli R, Saad E, Vasudev B, et al. Lower prevalence of BK virus infection in African American renal transplant recipients: a prospective study. Transplantation. 2012;93:291-6 pubmed publisher
    ..We undertook a prospective study to evaluate the risk factors for the occurrence of BKV infections using BK viruria and viremia as endpoints...
  33. Steffen I, Tyrrell D, Stein E, Montalvo L, Lee T, Zhou Y, et al. No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome. PLoS ONE. 2011;6:e27870 pubmed publisher
    ..Multiple techniques were employed, including nested and qRT-PCR, cell culture, and immunoblotting. We found no evidence of XMRV or MLV in humans and conclude that CFS is not associated with these gammaretroviruses...
  34. Pantulu N, Pallasch C, Kurz A, Kassem A, Frenzel L, Sodenkamp S, et al. Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells. Blood. 2010;116:5280-4 pubmed publisher
    ..The detection of MCPyV, including LTAg deletions and LTAg expression in CLL cells argues for a potential role of MCPyV in a significant subset of CLL cases. ..
  35. Groenewoud M, Fagrouch Z, van Gessel S, Niphuis H, Bulavaite A, Warren K, et al. Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans. J Gen Virol. 2010;91:653-8 pubmed publisher
    ..Neighbour-joining analysis positioned the viruses in a large cluster together with viruses from bats, bovines, rodents and several primate PyVs from chimpanzees, African green monkeys, squirrel monkeys and the human Merkel cell PyV...
  36. Tan C, Koralnik I. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9:425-37 pubmed publisher
    ..The increasingly diverse populations at risk and the recent discovery of the presence of the JC virus in the grey matter invite us to reappraise the pathogenesis of this virus in the CNS. ..
  37. Delbue S, Tremolada S, Elia F, Carloni C, Amico S, Tavazzi E, et al. Lymphotropic polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects. J Clin Virol. 2010;47:156-60 pubmed publisher
    ..However, given their high similarity, it is possible that LPV, as well as BKV and JCV, could establish latency in humans and cause disease only in rare circumstances. ..
  38. Touze A, Gaitan J, Maruani A, Le Bidre E, Doussinaud A, Clavel C, et al. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerg Infect Dis. 2009;15:960-2 pubmed publisher
    ..All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar...
  39. Roux D, Bouldouyre M, Mercier Delarue S, Seilhean D, Zagdanski A, Delaugerre C, et al. JC virus variant associated with cerebellar atrophy in a patient with AIDS. J Clin Microbiol. 2011;49:2196-9 pubmed publisher
    ..Our data underline the importance of searching for JCV in HIV-infected patients with cerebellar disorders and suggest that mutations in the regulatory region may be involved in cerebellar degeneration. ..
  40. Sanchez Fructuoso A, Calvo N, Perez Flores I, Valero R, Rodriguez Sanchez B, Garcia de Viedma D, et al. Mammalian target of rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients. Transpl Infect Dis. 2011;13:584-91 pubmed publisher
    ..Furthermore, target levels of immunosuppressive drugs are poorly defined, as are criteria for replacing one immunosuppressive agent with another...
  41. Santiago M, Smith D, Barrett B, Montano M, Benitez R, Pelanda R, et al. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011;85:189-99 pubmed publisher
    ..Overall, these findings argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3...
  42. Debiaggi M, Canducci F, Brerra R, Sampaolo M, Marinozzi M, Parea M, et al. Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. J Med Virol. 2010;82:153-6 pubmed publisher
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  43. Langlois M, Kemmerich K, Rada C, Neuberger M. The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3. J Virol. 2009;83:11550-9 pubmed publisher
  44. Boothpur R, Brennan D. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol. 2010;47:306-12 pubmed publisher
    ..There are no known effective antiviral agents for any of the polyoma viruses...
  45. Gill M, May J, Colaco S, Stevenson P. Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract. J Virol. 2010;84:10937-42 pubmed publisher
    ..RNR could therefore provide a good target for gammaherpesvirus chemotherapy...
  46. Helmbold P, Lahtz C, Herpel E, Schnabel P, Dammann R. Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer. Eur J Cancer. 2009;45:2207-11 pubmed publisher
    ..Our results show a high frequency of hypermethylation of the RASSF1A promoter and occurrence of MCPyV infection in the tumour tissue of SCLC. These events may contribute to the pathogenesis of SCLC. ..
  47. Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Denner J, et al. Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. Retrovirology. 2009;6:92 pubmed publisher
    ..Here, we attempt to measure the prevalence of XMRV in prostate cancer cases in Germany and determine whether an analogous association with the R462Q polymorphism exists...
  48. Mengelle C, Kamar N, Mansuy J, Sandres Saune K, Legrand Abravanel F, Miedouge M, et al. JC virus DNA in the peripheral blood of renal transplant patients: a 1-year prospective follow-up in France. J Med Virol. 2011;83:132-6 pubmed publisher
    ..JCV replication must still be diagnosed and differentiated from BK virus infection because of its non-aggressive course...
  49. Geddes C, Gunson R, Mazonakis E, Wan R, Thomson L, Clancy M, et al. BK viremia surveillance after kidney transplant: single-center experience during a change from cyclosporine-to lower-dose tacrolimus-based primary immunosuppression regimen. Transpl Infect Dis. 2011;13:109-16 pubmed publisher
    ..The aim was to report our experience of BK viremia surveillance after kidney transplant during a period of change from cyclosporine (CyA)-to lower-dose tacrolimus (Tac)-based primary immunosuppression regimens...
  50. Marur S, D Souza G, Westra W, Forastiere A. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010;11:781-9 pubmed publisher
  51. Carter J, Paulson K, Wipf G, Miranda D, Madeleine M, Johnson L, et al. Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. J Natl Cancer Inst. 2009;101:1510-22 pubmed publisher
    ..We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma...
  52. Ksiaa F, Ziadi S, Mokni M, Korbi S, Trimeche M. The presence of JC virus in gastric carcinomas correlates with patient's age, intestinal histological type and aberrant methylation of tumor suppressor genes. Mod Pathol. 2010;23:522-30 pubmed publisher
    ..11). Our study suggests a role of JCV as cofactor in the pathogenesis of the intestinal type of gastric carcinomas in older persons...
  53. Swanson P, Lukacher A, Szomolanyi Tsuda E. Immunity to polyomavirus infection: the polyomavirus-mouse model. Semin Cancer Biol. 2009;19:244-51 pubmed publisher
  54. Campello C, Comar M, Zanotta N, Minicozzi A, Rodella L, Poli A. Detection of SV40 in colon cancer: a molecular case-control study from northeast Italy. J Med Virol. 2010;82:1197-200 pubmed publisher
    ..However, the finding was not statistically significant when compared with a well-structured community control group. Thus, the role of SV40 and other polyomavirus in colon cancer genesis deserves further investigation...
  55. Santiago M, Benitez R, Montano M, Hasenkrug K, Greene W. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010;185:1114-23 pubmed publisher
    ..These findings raise the possibility that enabling Apobec3 activity during acute infection with human pathogenic retroviruses, such as HIV-1, may similarly facilitate stronger virus-specific neutralizing Ab responses...
  56. Martinez Fierro M, Leach R, Gomez Guerra L, Garza Guajardo R, Johnson Pais T, Beuten J, et al. Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer. 2010;10:326 pubmed publisher
    ..Association studies with the R462Q allele and non-XMRV viruses have not been reported. We assessed associations between prostate cancer, prostate viral infections, and the RNASEL 462Q allele in Mexican cancer patients and controls...
  57. Saundh B, Tibble S, Baker R, Sasnauskas K, Harris M, Hale A. Different patterns of BK and JC polyomavirus reactivation following renal transplantation. J Clin Pathol. 2010;63:714-8 pubmed publisher
  58. Sadeghi M, Riipinen A, Väisänen E, Chen T, Kantola K, Surcel H, et al. Newly discovered KI, WU, and Merkel cell polyomaviruses: no evidence of mother-to-fetus transmission. Virol J. 2010;7:251 pubmed publisher
    ..We also measured the MCPyV IgG antibodies in the corresponding maternal sera (N = 462) mostly from the first trimester...
  59. Leendertz F, Scuda N, Cameron K, Kidega T, Zuberb hler K, Leendertz S, et al. African great apes are naturally infected with polyomaviruses closely related to Merkel cell polyomavirus. J Virol. 2011;85:916-24 pubmed publisher
    ..This, together with the fact that humans in West and Central Africa frequently hunt and butcher primates, may point toward further MCPyV-like strains spreading to, or already existing in, our species...
  60. Arnold R, Makarova N, Osunkoya A, Suppiah S, Scott T, Johnson N, et al. XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH. Urology. 2010;75:755-61 pubmed publisher
  61. Babakir Mina M, Ciccozzi M, Farchi F, Bergallo M, Cavallo R, Adorno G, et al. KI and WU polyomaviruses and CD4+ cell counts in HIV-1-infected patients, Italy. Emerg Infect Dis. 2010;16:1482-5 pubmed publisher
    ..No association was found between cell counts and virus infections in HIV-1-positive patients. Frequency of KIPyV infection was similar for both groups. WUPyV was more frequent in HIV-1-positive patients...
  62. Schaub S, Hirsch H, Dickenmann M, Steiger J, Mihatsch M, Hopfer H, et al. Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy. Am J Transplant. 2010;10:2615-23 pubmed publisher
    ..6 mg/dl and 1.3 mg/dl, respectively. We conclude that screening for BKV-replication and reduction of immunosuppression is an effective strategy to preserve medium-term allograft function even in patients developing definitive PyVAN...
  63. Kantarci G, Eren Z, Demirag A, Dogan I, Cakalagaoglu F, Yilmaz G. JC virus-associated nephropathy in a renal transplant recipient and comparative analysis of previous cases. Transpl Infect Dis. 2011;13:89-92 pubmed publisher
  64. Boldorini R, Allegrini S, Miglio U, Paganotti A, Cocca N, Zaffaroni M, et al. Serological evidence of vertical transmission of JC and BK polyomaviruses in humans. J Gen Virol. 2011;92:1044-50 pubmed publisher
    ..These results suggest JC virus and BK virus can be transmitted from mother to newborn during pregnancy or soon after birth...
  65. Babakir Mina M, Ciccozzi M, Perno C, Ciotti M. The novel KI, WU, MC polyomaviruses: possible human pathogens?. New Microbiol. 2011;34:1-8 pubmed
    ..This review describes the general aspects of human polyomavirus infection and pathogenesis. Current topics of investigation and future directions in the field are also discussed...
  66. Maginnis M, Atwood W. JC virus: an oncogenic virus in animals and humans?. Semin Cancer Biol. 2009;19:261-9 pubmed publisher
    ..Here, we review the role of JCV in cancers in animal models and present the findings on JCV in human cancers...
  67. Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, Joensuu H. Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. Clin Cancer Res. 2011;17:4806-13 pubmed publisher
    ..Polyomaviruses repress tumor suppressor proteins, thus influencing cell-cycle progression, but the effect of MCPyV on the key cell-cycle regulating proteins is poorly understood...