alphavirus infections

Summary

Summary: Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.

Top Publications

  1. Jacups S, Whelan P, Harley D. Arbovirus models to provide practical management tools for mosquito control and disease prevention in the Northern Territory, Australia. J Med Entomol. 2011;48:453-60 pubmed
    ..These methods can be adapted for use elsewhere. ..
  2. Tan C, Wong P, Li M, Tan S, Lee T, Pang S, et al. Entomological investigation and control of a chikungunya cluster in Singapore. Vector Borne Zoonotic Dis. 2011;11:383-90 pubmed publisher
    ..This study suggests the benefit of a vector control program that includes the evaluation of control measures in conjunction to virological surveillance in vector population...
  3. Wang D, Suhrbier A, Penn Nicholson A, Woraratanadharm J, Gardner J, Luo M, et al. A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis. Vaccine. 2011;29:2803-9 pubmed publisher
    ..The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates. ..
  4. Mathew A, Goyal V, George E, Thekkemuriyil D, Jayakumar B, Chopra A. Rheumatic-musculoskeletal pain and disorders in a naïve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study. Int J Clin Pract. 2011;65:1306-12 pubmed publisher
    ..Although a causal association could not be established, this study has unravelled a wide spectrum of unrecognised post-CHIKV chronic RMSK disorders. Aetiopathogenesis and risk factors of chronicity need to be studied further. ..
  5. Sudeep A, Hundekar S, Jacob P, Balasubramanian R, Arankalle V, Mishra A. Investigation of a Chikungunya-like illness in Tirunelveli district, Tamil Nadu, India 2009-2010. Trop Med Int Health. 2011;16:585-8 pubmed publisher
    ..High prevalence of CHIKV IgM antibody positivity, clinical symptoms, virus isolation and the presence of vector mosquitoes clearly suggest CHIKV as the aetiological agent responsible for the outbreak. ..
  6. Grandadam M, Caro V, Plumet S, Thiberge J, Souares Y, Failloux A, et al. Chikungunya virus, southeastern France. Emerg Infect Dis. 2011;17:910-3 pubmed publisher
    ..Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe. ..
  7. Metcalf T, Griffin D. Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system. J Virol. 2011;85:11490-501 pubmed publisher
    ..However, there was no evidence of germinal center activity or IgG avidity maturation within the CNS...
  8. Kelvin A, Banner D, Silvi G, Moro M, Spataro N, Gaibani P, et al. Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity. PLoS Negl Trop Dis. 2011;5:e1279 pubmed publisher
    ..These data give insight into Chikungunya disease establishment and subsequent convalescence, which is imperative to the treatment and containment of this quickly evolving and frequently re-emerging disease...
  9. Pongsiri P, Auksornkitti V, Theamboonlers A, Luplertlop N, Rianthavorn P, Poovorawan Y. Entire genome characterization of Chikungunya virus from the 2008-2009 outbreaks in Thailand. Trop Biomed. 2010;27:167-76 pubmed

More Information

Publications90

  1. Morrison T, Oko L, Montgomery S, Whitmore A, Lotstein A, Gunn B, et al. A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence. Am J Pathol. 2011;178:32-40 pubmed publisher
  2. Boura M, Lucas Hourani M, Gad H, Drosten C, Jacob Y, Tafforeau L, et al. Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol. 2012;86:3121-34 pubmed publisher
    ..Altogether, this report provides the first interaction map between CHIKV and human proteins and describes new host cell proteins involved in the replication cycle of this virus...
  3. Zaid A, Rulli N, Rolph M, Suhrbier A, Mahalingam S. Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis. Arthritis Rheum. 2011;63:488-91 pubmed publisher
    ..This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease...
  4. Fric J, Bertin Maghit S, WANG C, Nardin A, Warter L. Use of human monoclonal antibodies to treat Chikungunya virus infection. J Infect Dis. 2013;207:319-22 pubmed publisher
    ..In both settings, 5F10 and 8B10 were able to significantly delay CHIKV-driven lethality. Our results support the development of prophylactic and therapeutic treatments for CHIKV infection, using a combination of 5F10 and 8B10...
  5. Naish S, Hu W, Mengersen K, Tong S. Spatial and temporal clusters of Barmah Forest virus disease in Queensland, Australia. Trop Med Int Health. 2011;16:884-93 pubmed publisher
  6. Couturier E, Guillemin F, Mura M, Leon L, Virion J, Letort M, et al. Impaired quality of life after chikungunya virus infection: a 2-year follow-up study. Rheumatology (Oxford). 2012;51:1315-22 pubmed publisher
    ..047 to <0.0001). Medical follow-up with special attention to comorbidity providing information on possible chronic symptoms and giving support for potential depression and anxiety are recommended. ..
  7. Kümmerer B, Grywna K, Gläsker S, Wieseler J, Drosten C. Construction of an infectious Chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites. J Gen Virol. 2012;93:1991-5 pubmed publisher
    ..The latter reporter viruses represent valuable tools for easy follow-up of replicating CHIKV useful in several applications of CHIKV research. ..
  8. Chaaitanya I, Muruganandam N, Sundaram S, Kawalekar O, Sugunan A, Manimunda S, et al. Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection. Viral Immunol. 2011;24:265-71 pubmed publisher
    ..The novel intervention strategies being developed for EPA and RA, such as IL-6 and IL-8 signaling blockade, may also be considered for chronic CHIKV arthritis. ..
  9. Lum F, Teo T, Lee W, Kam Y, Renia L, Ng L. An essential role of antibodies in the control of Chikungunya virus infection. J Immunol. 2013;190:6295-302 pubmed publisher
    ..Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection-induced specific Abs are essential for controlling CHIKV infections. ..
  10. Duong V, Andries A, Ngan C, Sok T, Richner B, Asgari Jirhandeh N, et al. Reemergence of Chikungunya virus in Cambodia. Emerg Infect Dis. 2012;18:2066-9 pubmed publisher
    ..Spatiotemporal patterns and phylogenetic clustering indicate that the virus probably originated in Thailand. ..
  11. Taraphdar D, Sarkar A, Mukhopadhyay B, Chatterjee S. A comparative study of clinical features between monotypic and dual infection cases with Chikungunya virus and dengue virus in West Bengal, India. Am J Trop Med Hyg. 2012;86:720-3 pubmed publisher
    ..Severe arthralgia and swelling of joints were common only in CHIKV-positive cases and abdominal pain was mainly associated with DENV infection. Diarrhea was reported only by the dual-infected patients (16.2%). ..
  12. Gould E, Gallian P, De Lamballerie X, Charrel R. First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality!. Clin Microbiol Infect. 2010;16:1702-4 pubmed publisher
  13. Coffey L, Beeharry Y, Borderia A, Blanc H, Vignuzzi M. Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci U S A. 2011;108:16038-43 pubmed publisher
    ..These results indicate that increased replication fidelity and reduced genetic diversity negatively impact arbovirus fitness in invertebrate and vertebrate hosts...
  14. Delogu I, Pastorino B, Baronti C, Nougairede A, Bonnet E, de Lamballerie X. In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant. Antiviral Res. 2011;90:99-107 pubmed publisher
    ..Finally, our results demonstrated the effective in vitro antiviral activity of ARB against CHIKV and gave some tracks to understand the molecular basis of ARB activity...
  15. Gibney K, Fischer M, Prince H, Kramer L, St George K, Kosoy O, et al. Chikungunya fever in the United States: a fifteen year review of cases. Clin Infect Dis. 2011;52:e121-6 pubmed publisher
    ..To minimize the risk of CHIKV spread in the United States, healthcare providers and public health officials should be educated about recognition, diagnosis, and reporting of CHIK cases. ..
  16. Ali Ou Alla S, Combe B. Arthritis after infection with Chikungunya virus. Best Pract Res Clin Rheumatol. 2011;25:337-46 pubmed publisher
  17. Chattopadhyay A, Wang E, Seymour R, Weaver S, Rose J. A chimeric vesiculo/alphavirus is an effective alphavirus vaccine. J Virol. 2013;87:395-402 pubmed publisher
    ..are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever...
  18. Moro M, Grilli E, Corvetta A, Silvi G, Angelini R, Mascella F, et al. Long-term chikungunya infection clinical manifestations after an outbreak in Italy: a prognostic cohort study. J Infect. 2012;65:165-72 pubmed publisher
    ..Following a Chikungunya (CHIKV) outbreak in Italy, a cohort study was conducted to describe the infection long-term clinical course and outcome...
  19. Wu D, Wu J, Zhang Q, Zhong H, Ke C, Deng X, et al. Chikungunya outbreak in Guangdong Province, China, 2010. Emerg Infect Dis. 2012;18:493-5 pubmed publisher
    ..Testing results confirmed that the pathogen causing the outbreak was chikungunya virus. Phylogenic analysis indicated that this virus was a member of the Indian Ocean clade of the East/Center/South African subgroup of chikungunya virus. ..
  20. Partidos C, Paykel J, Weger J, Borland E, Powers A, Seymour R, et al. Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccine. Vaccine. 2012;30:4638-43 pubmed publisher
    Emerging mosquito-borne alphavirus infections caused by chikungunya virus (CHIKV) or o'nyong-nyong virus (ONNV) are responsible for sporadic and sometimes explosive urban outbreaks...
  21. Nakaya H, Gardner J, Poo Y, Major L, Pulendran B, Suhrbier A. Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. Arthritis Rheum. 2012;64:3553-63 pubmed publisher
  22. Chusri S, Siripaitoon P, Hirunpat S, Silpapojakul K. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg. 2011;85:386-9 pubmed publisher
  23. Powers A. Genomic evolution and phenotypic distinctions of Chikungunya viruses causing the Indian Ocean outbreak. Exp Biol Med (Maywood). 2011;236:909-14 pubmed publisher
    ..This review will highlight some of the most significant recent research developments obtained using these cutting edge approaches for CHIKV...
  24. Forrester N, Palacios G, Tesh R, Savji N, Guzman H, Sherman M, et al. Genome-scale phylogeny of the alphavirus genus suggests a marine origin. J Virol. 2012;86:2729-38 pubmed publisher
    ..Complete genome sequencing of all members of the genus also revealed conserved residues forming the structural basis of the E1 and E2 protein dimers...
  25. Herath T, Bron J, Thompson K, Taggart J, Adams A, Ireland J, et al. Transcriptomic analysis of the host response to early stage salmonid alphavirus (SAV-1) infection in Atlantic salmon Salmo salar L. Fish Shellfish Immunol. 2012;32:796-807 pubmed publisher
    ..was evidence of rapid induction of interferon-mediated responses similar to those seen during mammalian alphavirus infections, and also early involvement of an adaptive immune response...
  26. Kam Y, Lum F, Teo T, Lee W, Simarmata D, Harjanto S, et al. Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med. 2012;4:330-43 pubmed publisher
    ..Mice vaccinated by E2EP3 peptides were protected against CHIKV with reduced viremia and joint inflammation, providing a pre-clinical basis for the design of effective vaccine against arthralgia-inducing CHIKV and other alphaviruses...
  27. Moulay D, Aziz Alaoui M, Cadivel M. The chikungunya disease: modeling, vector and transmission global dynamics. Math Biosci. 2011;229:50-63 pubmed publisher
    ..Global analysis of equilibria are given, which use on the one hand Lyapunov functions and on the other hand results of the theory of competitive systems and stability of periodic orbits...
  28. Krejbich Trotot P, Denizot M, Hoarau J, Jaffar Bandjee M, Das T, Gasque P. Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses. FASEB J. 2011;25:314-25 pubmed publisher
    ..Remarkably, viral replication in macrophages did not yield a proinflammatory response. We describe a novel infectious mechanism by which CHIKV invades host cells and escapes the host response...
  29. Schilte C, Staikowsky F, Staikovsky F, Couderc T, Madec Y, Carpentier F, et al. Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study. PLoS Negl Trop Dis. 2013;7:e2137 pubmed publisher
    ..Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya...
  30. Hertz J, Munishi O, Ooi E, Howe S, Lim W, Chow A, et al. Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg. 2012;86:171-7 pubmed publisher
    ..5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating...
  31. Chopra A, Anuradha V, Ghorpade R, Saluja M. Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study. Epidemiol Infect. 2012;140:842-50 pubmed publisher
    ..Chronic inflammatory arthritis was uncommon (0·3% at 1 year) although serum IL-6 often remained elevated in chronic cases. A larger population study is required to describe post-CHIKV rheumatism and its prognosis...
  32. Nkoghe D, Kassa R, Caron M, Grard G, Mombo I, Bikié B, et al. Clinical forms of chikungunya in Gabon, 2010. PLoS Negl Trop Dis. 2012;6:e1517 pubmed publisher
    ..We report a prospective study of clinical and biological features during an outbreak that occurred in Franceville, Gabon in 2010...
  33. Schilte C, Buckwalter M, Laird M, Diamond M, Schwartz O, Albert M. Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection. J Immunol. 2012;188:2967-71 pubmed publisher
    ..These results highlight the interplay between nonimmune and immune cells during Chikungunya virus infection and suggest an important role for nonhematopoietic cells as a critical source of IFN-?/?...
  34. Ray P, Ratagiri V, Kabra S, Lodha R, Sharma S, Sharma B, et al. Chikungunya infection in India: results of a prospective hospital based multi-centric study. PLoS ONE. 2012;7:e30025 pubmed publisher
    ..A prospective multi-centric study was conducted to evaluate clinical, epidemiological and virological features of chikugunya infection in patients with acute febrile illness from various geographical regions of India...
  35. Srikanth P, Sarangan G, Mallilankaraman K, Nayar S, Barani R, Mattew T, et al. Molecular characterization of Chikungunya virus during an outbreak in South India. Indian J Med Microbiol. 2010;28:299-302 pubmed publisher
    ..Re-emergence of Chikungunya is a major public health problem in the southern states of India...
  36. Lee V, Chow A, Zheng X, Carrasco L, Cook A, Lye D, et al. Simple clinical and laboratory predictors of Chikungunya versus dengue infections in adults. PLoS Negl Trop Dis. 2012;6:e1786 pubmed publisher
    ..This study compares their clinical presentation in Singapore adults to derive predictors to assist doctors in diagnostic decision-making...
  37. Warter L, Lee C, Thiagarajan R, Grandadam M, Lebecque S, Lin R, et al. Chikungunya virus envelope-specific human monoclonal antibodies with broad neutralization potency. J Immunol. 2011;186:3258-64 pubmed publisher
    ..Importantly, these mAbs will also represent precious tools for future studies on host-pathogen interactions and the rational design of vaccines against CHIKV...
  38. Kosasih H, Widjaja S, Surya E, Hadiwijaya S, Butarbutar D, Jaya U, et al. Evaluation of two IgM rapid immunochromatographic tests during circulation of Asian lineage Chikungunya virus. Southeast Asian J Trop Med Public Health. 2012;43:55-61 pubmed
    ..Increasing the reading time from the manufacturer's suggested time of 10 to 20 minutes significantly increased the sensitivity of the SD Bioline test to 68.2%, but did not significantly change its specificity...
  39. Weaver S, Osorio J, Livengood J, Chen R, Stinchcomb D. Chikungunya virus and prospects for a vaccine. Expert Rev Vaccines. 2012;11:1087-101 pubmed publisher
    ..Here, we discuss the challenges to the development of a safe, effective and affordable chikungunya vaccine and recent progress toward this goal...
  40. Dwibedi B, SABAT J, Mahapatra N, Kar S, Kerketta A, Hazra R, et al. Rapid spread of chikungunya virus infection in Orissa: India. Indian J Med Res. 2011;133:316-21 pubmed
    ..Epidemiological and laboratory investigation were carried out to confirm the cause of emerging illness, which was provisionally suspected as Chikungunya (CHIK) fever...
  41. Apandi Y, Lau S, Izmawati N, Amal N, Faudzi Y, Mansor W, et al. Identification of Chikungunya virus strains circulating in Kelantan, Malaysia in 2009. Southeast Asian J Trop Med Public Health. 2010;41:1374-80 pubmed
    ..In 2009, the strains circulating in Malaysia, including the state of Kelantan, based on the partial E1 gene, also belong to the Central/East African genotype...
  42. Herrero L, Nelson M, Bettadapura J, Gahan M, Mahalingam S. Applications of animal models of infectious arthritis in drug discovery: a focus on alphaviral disease. Curr Drug Targets. 2011;12:1024-36 pubmed
  43. Wikan N, Sakoonwatanyoo P, Ubol S, Yoksan S, Smith D. Chikungunya virus infection of cell lines: analysis of the East, Central and South African lineage. PLoS ONE. 2012;7:e31102 pubmed publisher
    ..The results suggest that the increased infectivity seen in insect cells derives from an evolution of the CHIKV genome not solely associated with the E1:226 substitution...
  44. Xu C, Mutoloki S, Evensen Ø. Superior protection conferred by inactivated whole virus vaccine over subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon (Salmo salar L.). Vaccine. 2012;30:3918-28 pubmed publisher
    ..The IWV vaccine has superior immunogenicity over sub-unit and DNA vaccines...
  45. Vega Rua A, Zouache K, Caro V, Diancourt L, Delaunay P, Grandadam M, et al. High efficiency of temperate Aedes albopictus to transmit chikungunya and dengue viruses in the Southeast of France. PLoS ONE. 2013;8:e59716 pubmed publisher
    ..In 2010, autochthonous cases of CHIK and dengue (DEN) were reported in southeastern France. We evaluated the potential of a French population of Ae. albopictus in the transmission of both viruses...
  46. Sam I, Kamarulzaman A, Ong G, Veriah R, Ponnampalavanar S, Chan Y, et al. Chikungunya virus-associated death in Malaysia. Trop Biomed. 2010;27:343-7 pubmed
    ..CHIKV infections may cause atypical, severe or fatal presentations...
  47. Kongtorp R, Stene A, Andreassen P, Aspehaug V, Graham D, Lyngstad T, et al. Lack of evidence for vertical transmission of SAV 3 using gametes of Atlantic salmon, Salmo salar L., exposed by natural and experimental routes. J Fish Dis. 2010;33:879-88 pubmed publisher
    ..It is concluded that if it happens at all, vertical transmission is of minor importance in the spread of SAV 3...
  48. Chua H, Abdul Rashid K, Law W, Hamizah A, Chem Y, Khairul A, et al. A fatal case of chikungunya virus infection with liver involvement. Med J Malaysia. 2010;65:83-4 pubmed
    ..He subsequently passed away due to cardiovascular collapse after 5 days of illness...
  49. Graham D, Frost P, McLaughlin K, Rowley H, Gabestad I, Gordon A, et al. A comparative study of marine salmonid alphavirus subtypes 1-6 using an experimental cohabitation challenge model. J Fish Dis. 2011;34:273-86 pubmed publisher
    ..These results demonstrate for the first time that shedding and transmission of virus may occur by both these routes and suggest that dispersal in these matrices should be included in any disease transmission models...
  50. Gardner C, Burke C, Higgs S, Klimstra W, Ryman K. Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate. Virology. 2012;425:103-12 pubmed publisher
    ..Glycosaminoglycan (GAG) binding may be a CHIKV vaccine attenuation mechanism as CHIKV-LR infectivity was not dependent upon GAG, while CHIKV-181/25 was highly dependent...
  51. Plante K, Wang E, Partidos C, Weger J, Gorchakov R, Tsetsarkin K, et al. Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism. PLoS Pathog. 2011;7:e1002142 pubmed publisher
    ..Furthermore, it is incapable of replicating in mosquito cells or infecting mosquitoes in vivo. This IRES-based attenuation platform technology may be useful for the predictable attenuation of any alphavirus...
  52. Pellot A, Alessandri J, Robin S, Samperiz S, Attali T, Brayer C, et al. [Severe forms of chikungunya virus infection in a pediatric intensive care unit on Reunion Island]. Med Trop (Mars). 2012;72 Spec No:88-93 pubmed
    ..This arboviral infection transmitted by a mosquito of the Aedes genus is usually benign. A surprising feature of the Reunion Island epidemic was the occurrence of rare severe forms involving adults as well as children...
  53. Sumathy K, Ella K. Genetic diversity of Chikungunya virus, India 2006-2010: evolutionary dynamics and serotype analyses. J Med Virol. 2012;84:462-70 pubmed publisher
    ..The study has provided insights into the origin, distribution and evolutionary adaptation of the virus to local vector abundance in the region that has reportedly, the highest incidence of CHIKV infection in the world...
  54. Wauquier N, Becquart P, Nkoghe D, Padilla C, Ndjoyi Mbiguino A, Leroy E. The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J Infect Dis. 2011;204:115-23 pubmed publisher
    ..Unlike other members of the alphavirus genus, immune responses to Chikungunya virus (CHIKV) have been poorly investigated...
  55. Werneke S, Schilte C, Rohatgi A, Monte K, Michault A, Arenzana Seisdedos F, et al. ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog. 2011;7:e1002322 pubmed publisher
  56. Naish S, Hu W, Mengersen K, Tong S. Spatio-temporal patterns of Barmah Forest virus disease in Queensland, Australia. PLoS ONE. 2011;6:e25688 pubmed publisher
    ..This study investigated the spatio-temporal patterns of BFV disease in Queensland, Australia using geographical information system (GIS) tools and geostatistical analysis...
  57. Rudd P, Wilson J, Gardner J, Larcher T, Babarit C, Le T, et al. Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock. J Virol. 2012;86:9888-98 pubmed publisher
  58. Aichinger G, Ehrlich H, Aaskov J, Fritsch S, Thomasser C, Draxler W, et al. Safety and immunogenicity of an inactivated whole virus Vero cell-derived Ross River virus vaccine: a randomized trial. Vaccine. 2011;29:9376-84 pubmed publisher
    ..Approximately 5000 cases of RRV disease, which is characterized by debilitating polyarthritis, are recorded each year in Australia. This study describes the first clinical trial of a candidate RRV vaccine...
  59. Thiberville S, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Negl Trop Dis. 2013;7:e2004 pubmed publisher
    ..Although almost all patients are outpatients, medical investigations mainly focused on hospitalised patients...
  60. Graham D, Fringuelli E, Rowley H, Cockerill D, Cox D, Turnbull T, et al. Geographical distribution of salmonid alphavirus subtypes in marine farmed Atlantic salmon, Salmo salar L., in Scotland and Ireland. J Fish Dis. 2012;35:755-65 pubmed publisher
    ..The significance of these results in relation to aspects of the epidemiology of infection, including transmission, biosecurity and wildlife reservoirs are discussed and knowledge gaps identified...
  61. Kumar M, Sudeep A, Arankalle V. Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against chikungunya virus. Vaccine. 2012;30:6142-9 pubmed publisher
    ..With the re-emergence of chikungunya virus (CHIKV) in an explosive form and in the absence of a commercially available vaccine, we aimed to develop candidate vaccines employing recombinant E2 protein or chemically inactivated whole virus...
  62. Manimunda S, Sugunan A, Rai S, Vijayachari P, Shriram A, Sharma S, et al. Outbreak of chikungunya fever, Dakshina Kannada District, South India, 2008. Am J Trop Med Hyg. 2010;83:751-4 pubmed publisher
    ..The present study is an indicator of the magnitude of the ongoing outbreak of CHIKV infection in India that started during 2005-2006...
  63. Kam Y, Simarmata D, Chow A, Her Z, Teng T, Ong E, et al. Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. J Infect Dis. 2012;205:1147-54 pubmed publisher
    ..Although infected individuals clear the virus from the blood, some develop debilitating and prolonged arthralgia...
  64. Doke P, Dakhure D, Patil A. A clinico-epidemiological study of Chikungunya outbreak in Maharashtra State, India. Indian J Public Health. 2011;55:313-6 pubmed publisher
    ..Inter-personal communication was best remembered. In health education, the role of paramedical workers and government doctors was prominent...
  65. Derraik J, Slaney D, Nye E, Weinstein P. Chikungunya virus: a novel and potentially serious threat to New Zealand and the South Pacific islands. Am J Trop Med Hyg. 2010;83:755-9 pubmed publisher
    ..In this report, we discuss the potential threat posed by chikungunya to the region, focusing in particular on New Zealand, and re-emphasizing the need for a South Pacific-wide approach towards mosquito-borne disease prevention...
  66. Mallilankaraman K, Shedlock D, Bao H, Kawalekar O, Fagone P, Ramanathan A, et al. A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLoS Negl Trop Dis. 2011;5:e928 pubmed publisher
    ..These data suggest a protective role for nAb against CHIKV disease and support further study of envelope-based CHIKV DNA vaccines...
  67. Dhanwani R, Khan M, Alam S, Rao P, Parida M. Differential proteome analysis of Chikungunya virus-infected new-born mice tissues reveal implication of stress, inflammatory and apoptotic pathways in disease pathogenesis. Proteomics. 2011;11:1936-51 pubmed publisher
    ..This is the first report unravelling the complicated pathways involved in the mechanism of Chikungunya disease pathogenesis employing proteomic approach...
  68. Soumahoro M, Boelle P, Gauzere B, Atsou K, Pelat C, Lambert B, et al. The Chikungunya epidemic on La Réunion Island in 2005-2006: a cost-of-illness study. PLoS Negl Trop Dis. 2011;5:e1197 pubmed publisher
    ..This study was conducted to assess the impact of chikungunya on health costs during the epidemic that occurred on La Réunion in 2005-2006...
  69. Frolova E, Gorchakov R, Pereboeva L, Atasheva S, Frolov I. Functional Sindbis virus replicative complexes are formed at the plasma membrane. J Virol. 2010;84:11679-95 pubmed publisher
  70. Bassetto M, De Burghgraeve T, Delang L, Massarotti A, Coluccia A, Zonta N, et al. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. Antiviral Res. 2013;98:12-8 pubmed publisher
    ..The study of such selective inhibitors will contribute to a better understanding of the CHIKV replication cycle and may represents a first step towards the development of a clinical candidate drug for the treatment of this disease...
  71. Chow A, Her Z, Ong E, Chen J, Dimatatac F, Kwek D, et al. Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis. 2011;203:149-57 pubmed publisher
    ..Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients...
  72. Tsetsarkin K, Chen R, Leal G, Forrester N, Higgs S, Huang J, et al. Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes. Proc Natl Acad Sci U S A. 2011;108:7872-7 pubmed publisher
    ..albopictus-adapted African strains. These results underscore how different adaptive landscapes occupied by closely related viral genotypes can profoundly affect the outcome of viral evolution and disease emergence...
  73. Pulmanausahakul R, Roytrakul S, Auewarakul P, Smith D. Chikungunya in Southeast Asia: understanding the emergence and finding solutions. Int J Infect Dis. 2011;15:e671-6 pubmed publisher
    ..This review seeks to provide a short update on the reemergence of chikungunya in Southeast Asia and the prospects for control of this disease...
  74. Rulli N, Rolph M, Srikiatkhachorn A, Anantapreecha S, Guglielmotti A, Mahalingam S. Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis. J Infect Dis. 2011;204:1026-30 pubmed publisher
    ..Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans...
  75. Burt F, Rolph M, Rulli N, Mahalingam S, Heise M. Chikungunya: a re-emerging virus. Lancet. 2012;379:662-71 pubmed publisher
    ..This Seminar focuses on the re-emergence of this disease, the clinical manifestations, pathogenesis of virus-induced arthralgia, diagnostic techniques, and various treatment modalities...
  76. Laoprasopwattana K, Kaewjungwad L, Jarumanokul R, Geater A. Differential diagnosis of Chikungunya, dengue viral infection and other acute febrile illnesses in children. Pediatr Infect Dis J. 2012;31:459-63 pubmed publisher
    ..It would be useful to be able to identify clinical manifestations that could reliably help to differentiate CHIK from dengue and other acute febrile illnesses during a CHIK outbreak in a dengue-endemic area...
  77. Dupuis Maguiraga L, Noret M, Brun S, Le Grand R, Gras G, Roques P. Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. PLoS Negl Trop Dis. 2012;6:e1446 pubmed publisher
  78. Metz S, Pijlman G. Arbovirus vaccines; opportunities for the baculovirus-insect cell expression system. J Invertebr Pathol. 2011;107 Suppl:S16-30 pubmed publisher
    ..The opportunities for recombinant baculoviruses to aid in the development of safe and effective subunit and virus-like particle vaccines against arboviral diseases are discussed...
  79. Jaffar Bandjee M, Ramful D, Gauzere B, Hoarau J, Krejbich Trotot P, Robin S, et al. Emergence and clinical insights into the pathology of Chikungunya virus infection. Expert Rev Anti Infect Ther. 2010;8:987-96 pubmed publisher
    ..Novel prevention measures to control the mosquito and a new vaccine are highly warranted...
  80. Chang S, Su C, Shu P, Yang C, Liao T, Cheng C, et al. Concurrent isolation of chikungunya virus and dengue virus from a patient with coinfection resulting from a trip to Singapore. J Clin Microbiol. 2010;48:4586-9 pubmed publisher
    ..Both viruses were successfully isolated from the coinfected case by using antibody neutralization and a plaque purification technique...
  81. Abere B, Wikan N, Ubol S, Auewarakul P, Paemanee A, Kittisenachai S, et al. Proteomic analysis of chikungunya virus infected microgial cells. PLoS ONE. 2012;7:e34800 pubmed publisher