visna

Summary

Alias: ovine encephalomyelitis
Summary: Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similar to but not the same as SCRAPIE.

Webpages

  1. medline publication: mapping domains of retroviral integrase responsible for viral dna specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/7637015
  2. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1164 ...
  3. medline publication: mapping viral dna specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteins
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/9499023
  4. publication: mapping viral dna specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteins
    www.fred.psu.edu/ds/retrieve/fred/publication/9499023
  5. idexx chekit caev and mvv test kits
    www.idexx.com/production/ruminant/ruminant14.jsp
  6. caprine arthritis-encephalitis virus
    www.vet.uga.edu/VPP/clerk/logan/index.php
  7. wahid interface - oie world animal health information database
    www.oie.int/wahis/public.php?page=disease
  8. sheep
    www.apd.rdg.ac.uk/AgEcon/livestockdisease/sheep.htm
  9. investigator: michael katzman
    www.fred.psu.edu/ds/retrieve/fred/investigator/mxk22
  10. ramón a. juste. neiker tecnalia,instituto vasco de investigación y desarrollo agrario. nekazal ikerketa eta garapenako euskal erakundea
    www.neiker.net/muestracontenido.asp?nodo1=0&nodo2=0&nodo3=0& ...

Research Grants

  1. Identifying a viral cause of Multiple Sclerosis
    Howard L Lipton; Fiscal Year: 2006
  2. MOLECULAR PATHOGENSIS OF LENTIVIRUS CNS DISEASE
    Janice E Clements; Fiscal Year: 2004
  3. RAMIFIED MICROGLIA AND LENTIVIRUS PERSISTENCE
    David L Huso; Fiscal Year: 2002

Publications

  1. Natural cases of visna in sheep with myelitis as the sole lesion in the central nervous system
    J Benavides
    Departamento de Patología Animal Medicina Animal, Anatomía Patológica, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s n, 24071 León, Spain
    J Comp Pathol 134:219-30
  2. Ovine lentivirus-associated leucomyelitis in naturally infected North American sheep
    E Biescas
    Department of Animal Pathology, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    J Comp Pathol 132:107-16
  3. Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes
    Changxin Wu
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Gen Virol 89:2586-96
  4. Detection of ovine lentivirus in the cumulus cells, but not in the oocytes or follicular fluid, of naturally infected sheep
    C Cortez Romero
    UPSP 5301 DGER, National Veterinary School, Nantes, France
    Theriogenology 66:1131-9
  5. Molecular characterization and phylogenetic study of Maedi Visna and Caprine Arthritis Encephalitis viral sequences in sheep and goats from Spain
    R Reina
    Institute of Agrobiotechnology, CSIC UPNA, Ctra Mutilva Baja s n, 31192 Mutilva Baja, Spain
    Virus Res 121:189-98
  6. Differential infection efficiencies of peripheral lung and tracheal tissues in sheep infected with Visna/maedi virus via the respiratory tract
    Tom N McNeilly
    Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Easter Bush, Midlothian EH25 9RG, UK
    J Gen Virol 88:670-9
  7. Immune response to maedi-visna virus
    Sigurbjorg Torsteinsdottir
    Institute for Experimental Pathology, University of Iceland, Keldur vid Vesturlandsveg, IS112 Reykjavik, Iceland
    Front Biosci 12:1532-43
  8. Visna virus-induced cytopathic effect in vitro is caused by apoptosis
    R Duval
    Laboratoire de Microbiologie, Faculté de Pharmacie, Limoges, France
    Arch Virol 147:943-59
  9. Immune response to individual maedi-visna virus gag antigens
    Inderpal Singh
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom CB3 0ES
    J Virol 80:912-9
  10. Maedi-visna virus and its relationship to human immunodeficiency virus
    Halldor Thormar
    University of Iceland, Institute of Biology, Sturlugata 7, 101 Reykjavik, Iceland
    AIDS Rev 7:233-45

Scientific Experts

  • Klaus Wimmers
  • Valgerdur Andrésdóttir
  • Gudmundur Pétursson
  • Halldor Thormar
  • Tom N McNeilly
  • F Mariotti
  • David L Huso
  • Howard L Lipton
  • Janice E Clements
  • J Benavides
  • Changxin Wu
  • Cyril Barbezange
  • Christophe Fraisier
  • Sigurbjorg Torsteinsdottir
  • Hallgrimur Arnarson
  • Ian McConnell
  • Barbara Blacklaws
  • R Reina
  • M C Ferreras
  • C Cortez Romero
  • Inderpal Singh
  • M Fuertes
  • E Biescas
  • J H Payne
  • W Sipos
  • R Duval
  • Barbara A Blacklaws
  • Maria Luisa Carrozza
  • Sergio Rosati
  • Francesco Tolari
  • Marie Suzan Monti
  • Marie Suzan-Monti
  • Gudmundur Petursson
  • Valgerdur Andresdottir
  • Gordon Harkiss
  • Beatriz Amorena
  • C Roux
  • E Berriatua
  • J J Badiola
  • A Contreras
  • I Glaria
  • F Fieni
  • B Amorena
  • Y Chebloune
  • J L Pellerin
  • R Z Mamoun
  • R Juste
  • C Solano
  • D Gelmetti
  • P Russo
  • J M Guibert
  • M I Mora
  • M Rolland
  • F Guiguen
  • S Preziuso
  • J C DeMartini
  • M Bulgin
  • S F E Scholes
  • D de B Welchman
  • W J Pepper
  • T Bainbridge
  • G C Pritchard
  • F Schmoll
  • C Bosgiraud
  • P J P Cardot

Detail Information

Webpages28

  1. medline publication: mapping domains of retroviral integrase responsible for viral dna specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/7637015
  2. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1164 ...
  3. medline publication: mapping viral dna specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteins
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/9499023
  4. publication: mapping viral dna specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteins
    www.fred.psu.edu/ds/retrieve/fred/publication/9499023
  5. idexx chekit caev and mvv test kits
    www.idexx.com/production/ruminant/ruminant14.jsp
  6. caprine arthritis-encephalitis virus
    www.vet.uga.edu/VPP/clerk/logan/index.php
  7. wahid interface - oie world animal health information database
    www.oie.int/wahis/public.php?page=disease
  8. sheep
    www.apd.rdg.ac.uk/AgEcon/livestockdisease/sheep.htm
  9. investigator: michael katzman
    www.fred.psu.edu/ds/retrieve/fred/investigator/mxk22
  10. ramón a. juste. neiker tecnalia,instituto vasco de investigación y desarrollo agrario. nekazal ikerketa eta garapenako euskal erakundea
    www.neiker.net/muestracontenido.asp?nodo1=0&nodo2=0&nodo3=0& ...
  11. prosopis spp. english
    www2.fpl.fs.fed.us/TechSheets/HardwoodNA/htmlDocs/prosop1.ht ...
  12. robert v. schoborg
    www.etsu.edu/com/microbiology/schoborg.aspx
  13. r&d projects. neiker tecnalia,instituto vasco de investigación y desarrollo agrario. nekazal ikerketa eta garapenako euskal erakundea
    www.neiker.net/verpagina.asp?buscar=&paginaactual=2&nodo1=20 ...
  14. medline publication: in vitro activities of purified visna virus integrase
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/8189495
  15. medline publication: influence of subterminal viral dna nucleotides on differential susceptibility to cleavage by human immunodeficiency virus type 1 and visna virus integrases
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/8971046
  16. medline publication: nucleophile selection for the endonuclease activities of human, ovine, and avian retroviral integrases
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/11024025
  17. wahid interface - oie world animal health information database
    www.oie.int/wahis/public.php?page=disease&WAHIDPHPSESSID=3dd ...
  18. study of the influence of environmental factors on infection by the maedi-visna virus of milk production flocks in semi-intensive and intensive farms in the basque country and castile-leon with the nervous and respiratory system forms of th
    www.neiker.net/muestracontenido.asp?idcontenido=2813&content ...
  19. småfevirus med stor variasjon / doktorgrader / forskning / hjem - veterinærinstituttet
    www.vetinst.no/nor/Forskning/Doktorgrader/Smaafevirus-med-st ...
  20. encephalitis
    lib.bioinfo.pl/meid:68958
  21. wahid interface - oie world animal health information database
    www.oie.int/wahis/public.php?page=disease_immediate_summary& ...
  22. publication: mapping domains of retroviral integrase responsible for viral dna specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases
    www.fred.psu.edu/ds/retrieve/fred/publication/7637015
  23. publication: influence of subterminal viral dna nucleotides on differential susceptibility to cleavage by human immunodeficiency virus type 1 and visna virus integrases
    www.fred.psu.edu/ds/retrieve/fred/publication/8971046
  24. publication: in vitro activities of purified visna virus integrase
    www.fred.psu.edu/ds/retrieve/fred/publication/8189495

Research Grants3

  1. Identifying a viral cause of Multiple Sclerosis
    Howard L Lipton; Fiscal Year: 2006
    ..Viral replication may be similar to that in Theiler's murine encephalomyelitis virus (TME\/) infection in mice or Visna virus infection in Icelandic sheep, relevant experimental viral models of MS...
  2. MOLECULAR PATHOGENSIS OF LENTIVIRUS CNS DISEASE
    Janice E Clements; Fiscal Year: 2004
    ..A key determinant for lentivirus replication is cellular activation. Recently, we discovered that visna virus activates mitogen-activated protein kinase (MAPK) as early as 15 minutes post-infection, and sustains MAPK ..
  3. RAMIFIED MICROGLIA AND LENTIVIRUS PERSISTENCE
    David L Huso; Fiscal Year: 2002
    ..organotypic brain slice cultures and dissociated cortical brain cultures that support microglial ramification and visna lentivirus infection in vitro...

Publications19

  1. Natural cases of visna in sheep with myelitis as the sole lesion in the central nervous system
    J Benavides
    Departamento de Patología Animal Medicina Animal, Anatomía Patológica, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s n, 24071 León, Spain
    J Comp Pathol 134:219-30
    Of 118 sheep with visna, 12 showed myelitis as the only nervous lesion. They were ovine lentivirus (OvLV)-seropositive and provirus DNA was demonstrated by LTR-PCR in all the samples with lesions...
  2. Ovine lentivirus-associated leucomyelitis in naturally infected North American sheep
    E Biescas
    Department of Animal Pathology, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    J Comp Pathol 132:107-16
    ..The results confirm the usefulness of the IHC and ISH for differential diagnosis of visna.
  3. Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes
    Changxin Wu
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Gen Virol 89:2586-96
    ..Infection of sheep with visna/maedi virus (VISNA), a related lentivirus, induces specific CD8(+) CTL in vivo, but the specific viral proteins ..
  4. Detection of ovine lentivirus in the cumulus cells, but not in the oocytes or follicular fluid, of naturally infected sheep
    C Cortez Romero
    UPSP 5301 DGER, National Veterinary School, Nantes, France
    Theriogenology 66:1131-9
    The aim of this study was to examine the Maedi-Visna virus (MVV) infection status of oocytes, cumulus cells, and follicular fluid taken from 140 ewes from breeding flocks...
  5. Molecular characterization and phylogenetic study of Maedi Visna and Caprine Arthritis Encephalitis viral sequences in sheep and goats from Spain
    R Reina
    Institute of Agrobiotechnology, CSIC UPNA, Ctra Mutilva Baja s n, 31192 Mutilva Baja, Spain
    Virus Res 121:189-98
    ..This suggests that there is heterogeneity at the primer binding site among Spanish SRLV sequences. It also illustrates the need to develop diagnostic tests that are sensitive in local breeds...
  6. Differential infection efficiencies of peripheral lung and tracheal tissues in sheep infected with Visna/maedi virus via the respiratory tract
    Tom N McNeilly
    Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Easter Bush, Midlothian EH25 9RG, UK
    J Gen Virol 88:670-9
    The main routes of transmission of Visna/maedi virus (VMV), an ovine lentivirus, are thought to be through ingestion of infected colostrum and/or milk or through inhalation of respiratory secretions...
  7. Immune response to maedi-visna virus
    Sigurbjorg Torsteinsdottir
    Institute for Experimental Pathology, University of Iceland, Keldur vid Vesturlandsveg, IS112 Reykjavik, Iceland
    Front Biosci 12:1532-43
    The ovine maedi-visna virus (MVV) was the first lentivirus to be isolated and characterized 1957 in Iceland. MVV leads to a life-long, persistent infection with slow development of lesions in the lung and the central nervous system (CNS)...
  8. Visna virus-induced cytopathic effect in vitro is caused by apoptosis
    R Duval
    Laboratoire de Microbiologie, Faculté de Pharmacie, Limoges, France
    Arch Virol 147:943-59
    b>Visna-Maedi virus (VMV), an ungulate lentivirus, causes a natural infection in sheep. In vitro, VMV infection and replication lead to strong cytopathic effects with subsequent death of host cells...
  9. Immune response to individual maedi-visna virus gag antigens
    Inderpal Singh
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom CB3 0ES
    J Virol 80:912-9
    The lesions caused by maedi-visna virus (MVV) are known to be immune mediated with a presumed contribution by the response to viral antigens. However, very little is known about the T-cell response to individual viral proteins...
  10. Maedi-visna virus and its relationship to human immunodeficiency virus
    Halldor Thormar
    University of Iceland, Institute of Biology, Sturlugata 7, 101 Reykjavik, Iceland
    AIDS Rev 7:233-45
    Maedi-visna is a slow virus infection of sheep leading to a progressing lymphoproliferative disease which is invariably fatal. It affects multiple organs, but primarily the lungs where it causes interstitial pneumonia (maedi)...
  11. CD4+CD25+ T cells in Maedi Visna infection: preliminary immunohistochemical study in experimentally infected sheep
    F Mariotti
    Department of Veterinary Sciences, University of Camerino, Matelica (MC, Italy
    Vet Res Commun 31:237-9
  12. Emergence of an apparently neurotropic maedi-visna virus infection in Britain
    J H Payne
    Vet Rec 154:94
  13. Expression of the gp150 maedi visna virus envelope precursor protein by mammalian expression vectors
    Christophe Fraisier
    Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    J Virol Methods 146:363-7
    There are very few previous reports of expression of native full-length maedi visna virus (MVV) Env gp150 protein in the literature...
  14. [Selection for disease and epidemic resistance in domestic ruminants and swine by indicator traits, marker and causal genes--a review. Part 2: Special immunogenetics of sheep and goats with particular regard for endoparasitoses, scrapie, foot rot and maed
    W Sipos
    II Medizinischen Universitätsklinik für Klauentiere der Veterinärmedizinischen Universität Wien
    Dtsch Tierarztl Wochenschr 110:3-10
    ..small ruminants in central and western Europe with special respect of endoparasitoses, scrapie, foot-rot and maedi-visna virus infection. Indicator traits are discussed with respect of their advantages and disadvantages...
  15. Diagnosis of the nervous form of Maedi-Visna infection with a high frequency in sheep in Castilla y Leon, Spain
    J Benavides
    Departamento de Patología Animal, Medicina Animal Anatomía Patológica, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s n, 24071 León, Spain
    Vet Rec 158:230-5
    Between 1997 and March 2004, the nervous form, or visna, of maedi-visna infection was diagnosed in 71 of 1631 sheep (4.35 per cent) examined in the Castilla y León region of Spain, of which 634 had shown nervous signs...