aids associated nephropathy

Summary

Summary: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.

Top Publications

  1. Obayomi O, Dillard M, Hosten A, Cruz I. End-stage renal disease in patients infected with human immunodeficiency virus: a retrospective review of 38 cases. J Natl Med Assoc. 1995;87:762-5 pubmed
    ..Risk factors for HIV infection in these patients were intravenous drug abuse, homosexual behavior, bisexual preference, and blood transfusion. None of these factors consistently influenced the survival of HIV-infected patients with ESRD...
  2. Bruggeman L, Dikman S, Meng C, Quaggin S, Coffman T, Klotman P. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest. 1997;100:84-92 pubmed
    ..These studies suggest that in humans, a direct effect of HIV-1 expression is likely the essential cause of HIVAN, rather than an indirect effect of cytokine dysregulation...
  3. Barisoni L, Mokrzycki M, Sablay L, Nagata M, Yamase H, Mundel P. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int. 2000;58:137-43 pubmed
    ..Exceptions to this rule are collapsing glomerulopathies (CGs), including HIV-associated nephropathy (HIVAN) and idiopathic CG, where podocytes undergo a dysregulation of their differentiated phenotype and proliferate...
  4. Shankland S, Eitner F, Hudkins K, Goodpaster T, D AGATI V, Alpers C. Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation. Kidney Int. 2000;58:674-83 pubmed
    ..In the current study, we determined the expression and possible role of specific CDK inhibitors in podocyte proliferation in human disease characterized by podocyte injury...
  5. Szczech L, Kalayjian R, Rodriguez R, Gupta S, Coladonato J, Winston J. The clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis. Kidney Int. 2003;63:2295-301 pubmed
    ..This study describes the clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis to define the clinical needs of this growing population...
  6. Kopp J, Smith M, Nelson G, Johnson R, Freedman B, Bowden D, et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008;40:1175-84 pubmed publisher
    ..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...
  7. Ross M, Klotman P. Recent progress in HIV-associated nephropathy. J Am Soc Nephrol. 2002;13:2997-3004 pubmed
  8. Abbott K, Hypolite I, Welch P, Agodoa L. Human immunodeficiency virus/acquired immunodeficiency syndrome-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival in the pre highly active antiretroviral therapy era. J Nephrol. 2001;14:377-83 pubmed
    ..The patient characteristics and course of HlV/AIDS-associated nephropathy (HIVAN) are presented for a national sample of end-stage renal disease (ESRD)...
  9. Kirchner J. Resolution of renal failure after initiation of HAART: 3 cases and a discussion of the literature. AIDS Read. 2002;12:103-5, 110-2 pubmed
    ..We report 3 patients believed to have HIVAN who exhibited marked improvement in renal function after treatment with a regimen comprising 2 nucleoside reverse transcriptase inhibitors and a protease inhibitor...

More Information

Publications62

  1. McArthur J. HIV dementia: an evolving disease. J Neuroimmunol. 2004;157:3-10 pubmed
    ..relating to HIV-dementia, including: (a) are there differing phenotypes or temporal patterns of progression in HIV-dementia? (b) what determines these temporal patterns? and (c), what has been the impact of therapy on HIV dementia?..
  2. Husain M, Gusella G, Klotman M, Gelman I, Ross M, Schwartz E, et al. HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. J Am Soc Nephrol. 2002;13:1806-15 pubmed
    ..These data indicate that Nef induces multiple proliferative effects in podocytes in culture and that nef may therefore be an important gene in the pathogenesis of HIVAN in vivo...
  3. Rao T. Human immunodeficiency virus infection and renal failure. Infect Dis Clin North Am. 2001;15:833-50 pubmed
  4. Afsari K, Frank J, Vaksman Y, Nguyen T. Intracranial venous sinus thrombosis complicating AIDS-associated nephropathy. AIDS Read. 2003;13:143-8 pubmed
    ..This is the first reported case of fatal ICVST and RVT with extensive cerebral hemorrhagic infarcts complicating nephrotic syndrome in a patient with AIDS...
  5. Chaparro A, Mitchell C, Abitbol C, Wilkinson J, Baldarrago G, Lopez E, et al. Proteinuria in children infected with the human immunodeficiency virus. J Pediatr. 2008;152:844-9 pubmed publisher
    ..To determine the prevalence of proteinuria in a large cohort of children infected with the human immunodeficiency virus (HIV) and their longitudinal progression during treatment with highly active antiretroviral therapy...
  6. Izzedine H, Launay Vacher V, Deray G. Antiretroviral drugs and the kidney: dosage adjustment and renal tolerance. Curr Pharm Des. 2004;10:4071-9 pubmed
    ..6 to 1%). Therefore, administration of antiretroviral drugs in human immunodeficiency virus (HIV) patients with nephropathy is not uncommon...
  7. Arora S, Husain M, Kumar D, Patni H, Pathak S, Mehrotra D, et al. Human immunodeficiency virus downregulates podocyte apoE expression. Am J Physiol Renal Physiol. 2009;297:F653-61 pubmed publisher
    ..These findings suggest that HIV-1-induced reduction in podocyte apoE expression and associated downregulation of podocyte perlecan might be contributing to mesangial cell (MC) phenotype in HIVAN...
  8. Ross M, Martinka S, D Agati V, Bruggeman L. NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J Am Soc Nephrol. 2005;16:2403-11 pubmed
    ..These results suggest that NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium...
  9. Naicker S, Han T, Fabian J. HIV/AIDS--dominant player in chronic kidney disease. Ethn Dis. 2006;16:S2-56-60 pubmed
    ..Preventive strategies need to be determined; prospective studies including antiretroviral therapy, angiotensin-converting enzyme inhibitors, and other therapeutic agents are required...
  10. Wyatt C, Klotman P. HIV-1 and HIV-Associated Nephropathy 25 Years Later. Clin J Am Soc Nephrol. 2007;2 Suppl 1:S20-4 pubmed
    ..This article reviews the history of HIV and HIVAN, focusing on advances in the understanding of pathogenesis, epidemiology, and treatment...
  11. Cavalcante M, Coelho S, Lacerda H. Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy. Braz J Infect Dis. 2007;11:456-61 pubmed
    ..The prevalence of PPt was 5.6% (95% CI = 3.6 to 8.3%), and it was significantly associated with a low CD4 lymphocyte count (p<0.048). HIVAN was found in just one patient, and two patients improved after HAART...
  12. Mokrzycki M, Oo T, Patel K, Chang C. Human immunodeficiency virus-associated nephropathy in the Bronx: low prevalence in a predominantly Hispanic population. Am J Nephrol. 1998;18:508-12 pubmed
    ..In summary, the risk of HIVAN in Hispanics is similar to that for whites. Male sex is not an independent risk factor. Both renal and patient survival are similar in blacks and Hispanics, and in men compared to women...
  13. Tokizawa S, Shimizu N, Hui Yu L, Deyu F, Haraguchi Y, Oite T, et al. Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. Kidney Int. 2000;58:607-17 pubmed
    ..More than ten G protein-coupled receptors, including chemokine receptors, have been shown to act as HIV-1 coreceptors that determine the susceptibilities of cells to HIV-1 strains with specific cell tropisms...
  14. Winston J. Editorial comment: the increasing problem of HIV-associated nephropathy. AIDS Read. 2002;12:110-1 pubmed
  15. Audard V, Avouac J, Wirden M, Pardon A, Matignon M, Remy P, et al. HIV-related nephropathies associated with changes in blood and kidney tissue virus load. Kidney Int. 2008;73:651-5 pubmed publisher
  16. Zerhouni Layachi B, Husain M, Ross M, Marras D, Sunamoto M, Liu X, et al. Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. AIDS. 2006;20:621-4 pubmed
    ..HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed...
  17. Tanji N, Ross M, Tanji K, Bruggeman L, Markowitz G, Klotman P, et al. Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reaction. Histol Histopathol. 2006;21:393-401 pubmed publisher
    ..IS-PCR is a powerful technique to detect viral DNA in human tissue sections, but requires proper use of negative controls to set optimal fixation, protein digestion, and amplification conditions...
  18. Martinka S, Bruggeman L. Persistent NF-kappaB activation in renal epithelial cells in a mouse model of HIV-associated nephropathy. Am J Physiol Renal Physiol. 2006;290:F657-65 pubmed
    ..In addition, because NF-kappaB regulates many aspects of inflammation, this dysregulation may also contribute to disease severity and progression through regulation of proinflammatory processes in the kidney microenvironment...
  19. Hammer S, Eron J, Reiss P, Schooley R, Thompson M, Walmsley S, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA. 2008;300:555-70 pubmed publisher
  20. Balow J. Nephropathy in the context of HIV infection. Kidney Int. 2005;67:1632-3 pubmed
  21. Nwankwo E, Ene A. HIV infection in patients requiring dialysis in Maiduguri, Nigeria. Int J Artif Organs. 2004;27:1000-2 pubmed
  22. Di Belgiojoso G, Ferrario F, Landriani N. Virus-related glomerular diseases: histological and clinical aspects. J Nephrol. 2002;15:469-79 pubmed
    ..Renal biopsy is useful for defining virus-related glomerular lesions and a guide for prognostic and therapeutic evaluation...
  23. Szczech L. Research in HIV-related renal diseases lags behind their burden to the 'positive' community. Kidney Int. 2007;72:1303-5 pubmed
    ..suggests that they remain similar to or worse than outcomes for persons with diabetes mellitus. This study should be used to frame the research resources that we devote to furthering knowledge in this area...
  24. Estrella M, Fine D. Screening for chronic kidney disease in HIV-infected patients. Adv Chronic Kidney Dis. 2010;17:26-35 pubmed publisher
    ..This review focuses on the current guidelines for kidney disease screening and discusses traditional as well as promising strategies for detecting CKD in this vulnerable population...
  25. Ray P, Xu L, Rakusan T, Liu X. A 20-year history of childhood HIV-associated nephropathy. Pediatr Nephrol. 2004;19:1075-92 pubmed
    ..Hopefully, in the near future, better education, prevention, and treatment programs will lead to the eradication of this fatal childhood disease...
  26. Wong K, Liu Y, Leung K, Choi K, Chau K, Li P, et al. Corticosteroid therapy in a Chinese patient with nephropathy associated with human immunodeficiency virus infection. Hong Kong Med J. 2004;10:201-5 pubmed
    ..To the best of our knowledge, this is the first documented case of nephropathy associated with human immunodeficiency virus infection occurring in Hong Kong...
  27. Zuo Y, Matsusaka T, Zhong J, Ma J, Ma L, Hanna Z, et al. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J Am Soc Nephrol. 2006;17:2832-43 pubmed
    ..In contrast, all vpr or nef single-transgenic mice in the same litter uniformly showed no or much milder podocyte injury. These findings indicate that vpr and nef each can induce podocyte injury with a prominent synergistic interaction...
  28. Winston J, Klotman M, Klotman P. HIV-associated nephropathy is a late, not early, manifestation of HIV-1 infection. Kidney Int. 1999;55:1036-40 pubmed
    ..In this study, we reassessed the stage of infection at the time of HIVAN diagnosis in 10 patients, and we reviewed all previously published cases applying the new case definitions to assess stage of infection...
  29. de Silva T, Post F, Griffin M, Dockrell D. HIV-1 infection and the kidney: an evolving challenge in HIV medicine. Mayo Clin Proc. 2007;82:1103-16 pubmed
    ..Host factors may modify disease expression at the level of cytokine networks and the renal microvasculature and contribute to the pathogenic effects of HIV-1 infection on the kidney...
  30. Sakurai N, Kuroiwa T, Ikeuchi H, Hiramatsu N, Takeuchi S, Tomioka M, et al. Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy. Nephrol Dial Transplant. 2009;24:2378-83 pubmed publisher
    ..Recent studies have reported that statins have renoprotective effects, independent from lowering plasma cholesterol. In this study, we examined whether statins were beneficial in a murine model of HIV-associated nephropathy (HIVAN)...
  31. MacRae J, Friedman A, Eggers P, Friedman E. Improved survival in HIV-infected African-Americans with ESRD. Clin Nephrol. 2005;64:124-8 pubmed
    ..To determine if there has been improvement in survival of HIV-infected patients with end-stage renal failure subsequent to widespread use of highly active antiretroviral therapy...
  32. Kalayjian R. The treatment of HIV-associated nephropathy. Adv Chronic Kidney Dis. 2010;17:59-71 pubmed publisher
    ..Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy...
  33. Roberts A, Maung R, Sejbuk N, Ake C, Kaul M. Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120. J Neurosci Methods. 2010;186:222-5 pubmed publisher
    ..Thus this experimental model system may be useful to further study the mechanistic interaction of both the viral envelope protein and the psychostimulant drug in behavioural alterations and neurodegenerative disease...
  34. Hedayati S, Reddan D, Szczech L. HIV-associated nephropathy: a review of the epidemiology and clinical course in the HAART era. AIDS Patient Care STDS. 2003;17:57-63 pubmed
  35. Lucas G, Mehta S, Atta M, Kirk G, Galai N, Vlahov D, et al. End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004. AIDS. 2007;21:2435-43 pubmed
    ..HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT)...
  36. Chamton N, Tellier E, Zins D, Dubreuil Lemaire -, Zazemp V. Haemodialysis and H.I.V. infection--therapeutic management. EDTNA ERCA J. 2001;27:34-6 pubmed
    ..The prevalence of human immunodeficiency virus among haemodialysis patients is of interest and this article discusses the management of 25 patients between 1985 and 1998 in Paris...
  37. Wrone E, Carey H, Reilly R. Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference. Yale J Biol Med. 1997;70:161-73 pubmed
    ..The first that renal disease can be the first manifestation of HIV infection and the second that HIV-infected patients may develop immune complex related renal diseases, some of which may be potentially treatable...
  38. Cohen S, Kimmel P. HIV-associated renal diseases in Africa a desperate need for additional study. Nephrol Dial Transplant. 2007;22:2116-9 pubmed
  39. Afhami S, Rasoulinejad M, Razeghi E, Shahriari S, Esmailpour N. Renal disorders in HIV-infected patients. Arch Iran Med. 2007;10:335-8 pubmed
  40. Marras D. Genetic analysis of HIV by in situ PCR-directed laser capture microscopy of infected cells. Methods Mol Biol. 2005;293:271-83 pubmed
    ..This chapter describes laser capture microdissection and in situ PCR and its role in the analysis of the genetic nature of HIV-1 variants and quasispecies...
  41. Ratai E, Bombardier J, Joo C, Annamalai L, Burdo T, Campbell J, et al. Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS. PLoS ONE. 2010;5:e10523 pubmed publisher
  42. Mayor A, DWORKIN M, Quesada L, Rios Olivares E, Hunter Mellado R. The morbidity and mortality associated with kidney disease in an HIV-infected cohort in Puerto Rico. Ethn Dis. 2010;20:S1-163-7 pubmed
    ..Nephropathy in HIV-infected patients has been associated with progression to AIDS and death. The virus, several comorbid conditions and certain medications may contribute to the development and progression of kidney disease...
  43. Fine D, Atta M. Kidney disease in the HIV-infected patient. AIDS Patient Care STDS. 2007;21:813-24 pubmed publisher
    ..Success in confronting this growing problem can only be achieved with better understanding of kidney diseases affecting the HIV population...
  44. Estrella M, Fine D, Gallant J, Rahman M, Nagajothi N, Racusen L, et al. HIV type 1 RNA level as a clinical indicator of renal pathology in HIV-infected patients. Clin Infect Dis. 2006;43:377-80 pubmed
    ..Hypertensive vascular disease surpassed HIV-associated nephropathy as the most common renal pathological finding among the entire cohort. HIV-1 RNA level did not correlate with renal survival...
  45. Kumar M, Sierka D, Damask A, Fyfe B, McAlack R, Heifets M, et al. Safety and success of kidney transplantation and concomitant immunosuppression in HIV-positive patients. Kidney Int. 2005;67:1622-9 pubmed
  46. Nzerue C, Gowda A. Legionella micdadei lung abscess in a patient with HIV-associated nephropathy. J Natl Med Assoc. 2001;93:220-3 pubmed
    ..After a 6-week course of antibiotics and drainage, the patient made an uneventful recovery. Infections due to L. micdadei may be hard to diagnose because of difficulties in isolating this bacteria...
  47. Schwartzman W, Patnaik M, Barka N, Peter J. Rochalimaea antibodies in HIV-associated neurologic disease. Neurology. 1994;44:1312-6 pubmed
    ..In the 14 patients for whom clinical data were available, evidence of CNS invasion by R henselae was accompanied by acute and subacute mental status changes including hallucinations, disorientation, and rapidly progressive dementia...
  48. Steciwko A, Mastalerz Migas A, Rutkowski B, Simon K. [Problem of HIV-infected patients receiving dialysis]. Przegl Lek. 2004;61:185-91 pubmed
    ..We present also algorithms of management with patient with acute/chronic renal failure in dependence on result of HIV test...
  49. Winston J. HIV and CKD epidemiology. Adv Chronic Kidney Dis. 2010;17:19-25 pubmed publisher
    ..A review of these data provides the foundation for a better understanding of kidney disease and, hopefully, better treatment for patients with HIV...
  50. Rodriguez R. Editorial comment: effect of HAART on HIVAN--what can the clinician expect?. AIDS Read. 2004;14:446-7 pubmed
  51. Miller M, Williams J. Chronic renal failure in Jamaican children--an update (2001-2006). West Indian Med J. 2009;58:231-4 pubmed
    ..This study evaluated the incidence, epidemiology, aetiology and outcome of chronic renal failure (CRF) in Jamaican children < 12 years old between 2001 and 2006...
  52. Mathieson P. Glomerulonephritis in the tropics: who are the culprits?. Ethn Dis. 2006;16:S2-52-5 pubmed
    ..This article highlights some general principles regarding glomerular disease in the developing world, illustrated by the author's experience in rural Uganda...
  53. Cohen A, Cohen G. Distinguished Scientists Lecture Series. HIV-associated nephropathy. Nephron. 1999;83:111-6 pubmed
    ..Therapy with zidovudine, corticosteroids, or angiotensin-converting enzyme inhibitors has met with modest success; to date, protease inhibitors have not been assessed...