feline acquired immunodeficiency syndrome

Summary

Summary: Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV).

Top Publications

  1. Barr M, Huitron Resendiz S, Selway D, Henriksen S, Phillips T. Exogenous glucocorticoids alter parameters of early feline immunodeficiency virus infection. J Infect Dis. 2000;181:576-86 pubmed
    ..These results emphasize the complexity of host-lentivirus interactions and suggest potential advantages and drawbacks of using glucocorticoids in lentivirus infections...
  2. Little S, Bienzle D, Carioto L, Chisholm H, O Brien E, Scherk M. Feline leukemia virus and feline immunodeficiency virus in Canada: recommendations for testing and management. Can Vet J. 2011;52:849-55 pubmed
    ..Finally, more information is needed on FIV subtypes in Canada to improve diagnostics and vaccines, and to provide information on disease outcomes...
  3. Leutenegger C, Klein D, Hofmann Lehmann R, Mislin C, Hummel U, Boni J, et al. Rapid feline immunodeficiency virus provirus quantitation by polymerase chain reaction using the TaqMan fluorogenic real-time detection system. J Virol Methods. 1999;78:105-16 pubmed
    ..Comparison of the TaqMan system with a conventional seminested PCR assay revealed a comparable detection limit and good correlation. Furthermore the design of the two probes allowed the detection of various FIV isolates of clade A and B...
  4. Hartmann K. Clinical aspects of feline retroviruses: a review. Viruses. 2012;4:2684-710 pubmed publisher
    ..This article provides a review of clinical syndromes in progressively and regressively FeLV-infected cats as well as in FIV-infected cats...
  5. Poli A, Tozon N, Guidi G, Pistello M. Renal alterations in feline immunodeficiency virus (FIV)-infected cats: a natural model of lentivirus-induced renal disease changes. Viruses. 2012;4:1372-89 pubmed publisher
  6. Miller C, Bielefeldt Ohmann H, Macmillan M, Huitron Resendiz S, Henriksen S, Elder J, et al. Strain-specific viral distribution and neuropathology of feline immunodeficiency virus. Vet Immunol Immunopathol. 2011;143:282-91 pubmed publisher
    ..This study illustrates the potential for FIV to provide valuable information about neuroAIDS pathogenesis related to genotype and viral kinetics, as well as to identify strains useful to evaluation of therapeutic intervention...
  7. Dietrich I, MacIntyre A, McMonagle E, Price A, James L, McEwan W, et al. Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion. J Virol. 2010;84:8980-5 pubmed publisher
    ..FeTRIMCyp and FIV infections of the cat offer a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS...
  8. Gleich S, Krieger S, Hartmann K. Prevalence of feline immunodeficiency virus and feline leukaemia virus among client-owned cats and risk factors for infection in Germany. J Feline Med Surg. 2009;11:985-92 pubmed publisher
    ..Median survival time of FIV-infected cats was not significantly different to non-infected cats, whereas FeLV-infected cats had significantly shorter median survival times than non-infected cats...
  9. Shen X, Leutenegger C, Stefano Cole K, Pedersen N, Sparger E. A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. J Gen Virol. 2007;88:2793-9 pubmed
    ..Overall, these findings confirmed that the severe virus attenuation for both replication and pathogenicity exhibited by a vif-deleted FIV mutant is similar for both neonatal and adult hosts...

More Information

Publications62

  1. Poss M, Ross H, Painter S, Holley D, Terwee J, Vandewoude S, et al. Feline lentivirus evolution in cross-species infection reveals extensive G-to-A mutation and selection on key residues in the viral polymerase. J Virol. 2006;80:2728-37 pubmed publisher
  2. Joshi A, Vahlenkamp T, Garg H, Tompkins W, Tompkins M. Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation. Virology. 2004;321:307-22 pubmed
    ..On the contrary, CD4(+)CD25(-) cells seem to establish as latent viral reservoirs capable of being reactivated after stimulation...
  3. Hosie M, Beatty J. Vaccine protection against feline immunodeficiency virus. Aust Vet J. 2007;85:302-3 pubmed
  4. Norris J, Bell E, Hales L, Toribio J, White J, Wigney D, et al. Prevalence of feline immunodeficiency virus infection in domesticated and feral cats in eastern Australia. J Feline Med Surg. 2007;9:300-8 pubmed
    ..This study provides cogent baseline FIV prevalences in three cat subpopulations which can be used for appraising potential disease associations with FIV in Australia...
  5. Miller M, Fogle J. Administration of Fozivudine tidoxil as a single-agent therapeutic during acute feline immunodeficiency virus infection does not alter chronic infection. Viruses. 2012;4:954-62 pubmed publisher
  6. Dean G, Lavoy A, Burkhard M. Peptide mapping of feline immunodeficiency virus by IFN-gamma ELISPOT. Vet Immunol Immunopathol. 2004;100:49-59 pubmed
    ..The IFN-gamma ELISPOT assay and FIV-specific peptide pools we describe here will be useful in assessing cell-mediated responses to experimental FIV vaccines...
  7. Lockett N, Scott V, Boudreaux C, Clay B, Pruett S, Ryan P, et al. Expression of regulatory T cell (Treg) activation markers in endometrial tissues from early and late pregnancy in the feline immunodeficiency virus (FIV)-infected cat. Placenta. 2010;31:796-802 pubmed publisher
    ..These cells may be depleted or rendered less functional by viral infection, but understanding their role in pregnancy requires further study...
  8. Boudreaux C, Lockett N, Chemerys D, Clay B, Scott V, Willeford B, et al. Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation. Vet Immunol Immunopathol. 2009;131:290-7 pubmed publisher
    ..However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome...
  9. Luttge B, Freed E. FIV Gag: virus assembly and host-cell interactions. Vet Immunol Immunopathol. 2010;134:3-13 pubmed publisher
    ..This review summarizes currently known interactions involving HIV-1 and FIV Gag that affect virus release, infectivity, and replication. ..
  10. Yamamoto J, Pu R, Sato E, Hohdatsu T. Feline immunodeficiency virus pathogenesis and development of a dual-subtype feline-immunodeficiency-virus vaccine. AIDS. 2007;21:547-63 pubmed
  11. Dias A, Bester M, Britz R, Apostolides Z. Animal models used for the evaluation of antiretroviral therapies. Curr HIV Res. 2006;4:431-46 pubmed
  12. Lehman T, O Halloran K, Fallon S, Habermann L, Campbell J, Nordone S, et al. Altered bone marrow dendritic cell cytokine production to toll-like receptor and CD40 ligation during chronic feline immunodeficiency virus infection. Immunology. 2009;126:405-12 pubmed publisher
  13. Willett B, McMonagle E, Logan N, Schneider P, Hosie M. Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus. Mol Immunol. 2009;46:1020-30 pubmed publisher
  14. Pontier D, Fouchet D, Bahi Jaber N, Poulet H, Guiserix M, Natoli E, et al. When domestic cat (Felis silvestris catus) population structures interact with their viruses. C R Biol. 2009;332:321-8 pubmed publisher
    ..In the present article, we show how cat population structure may have influenced the evolution of feline viruses and, in return, how these viruses may have modified the genetic structure of cat populations...
  15. Levy J, Scott H, Lachtara J, Crawford P. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity. J Am Vet Med Assoc. 2006;228:371-6 pubmed
    ..To determine seroprevalence of FeLV and FIV infection among cats in North America and risk factors for seropositivity...
  16. Domenech A, Miró G, Collado V, Ballesteros N, Sanjosé L, Escolar E, et al. Use of recombinant interferon omega in feline retrovirosis: from theory to practice. Vet Immunol Immunopathol. 2011;143:301-6 pubmed publisher
    ..More studies are needed in order to better understand its in vivo mechanisms...
  17. Ritchey J, Levy J, Bliss S, Tompkins W, Tompkins M. Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats. Vet Immunol Immunopathol. 2001;79:83-100 pubmed
    ..In summary, pulmonary immune changes seen in FIV-infected cats are similar to those seen in HIV-infected human patients...
  18. Stokes C, Finerty S, Gruffydd Jones T, Sturgess C, Harbour D. Mucosal infection and vaccination against feline immunodeficiency virus. J Biotechnol. 1999;73:213-21 pubmed
    ..In a preliminary study we have also been able to detect FIV specific CTLs and have observed protection from rectal challenge in four out of four cats...
  19. Hofmann Lehmann R, Holznagel E, Ossent P, Lutz H. Parameters of disease progression in long-term experimental feline retrovirus (feline immunodeficiency virus and feline leukemia virus) infections: hematology, clinical chemistry, and lymphocyte subsets. Clin Diagn Lab Immunol. 1997;4:33-42 pubmed
    ..The many parallels between laboratory parameters in FIV and HIV infection further support the importance of FIV as a model for HIV...
  20. Tompkins M, Tompkins W. Lentivirus-induced immune dysregulation. Vet Immunol Immunopathol. 2008;123:45-55 pubmed publisher
    ..As such, the natural history and pathogenesis provides an excellent model to study the long-term relationships between AIDS lentivirus and host immune system function/dysregulation...
  21. Zielonka J, Marino D, Hofmann H, Yuhki N, Lochelt M, Munk C. Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids. J Virol. 2010;84:7312-24 pubmed publisher
    ..We conclude that the replication of HIV-1 in some feline cells is inhibited only by feline A3 restriction factors and the absence of the appropriate receptor or coreceptor...
  22. Bull M, Kennedy Stoskopf S, Levine J, Loomis M, Gebhard D, Tompkins W. Evaluation of T lymphocytes in captive african lions (Panthera leo) infected with feline immunodeficiency virus. Am J Vet Res. 2003;64:1293-300 pubmed
    ..To determine whether FIV infection in captive African lions is associated with changes in immune cell variables similar to those detected in domestic cats infected with FIV...
  23. Kenyon J, Lever A. The molecular biology of feline immunodeficiency virus (FIV). Viruses. 2011;3:2192-213 pubmed publisher
    ..This review summarizes our current knowledge of FIV molecular biology and its similarities with, and differences from, other lentiviruses...
  24. Pedretti E, Passeri B, Amadori M, Isola P, Di Pede P, Telera A, et al. Low-dose interferon-alpha treatment for feline immunodeficiency virus infection. Vet Immunol Immunopathol. 2006;109:245-54 pubmed
  25. Kanzaki L, Looney D. Feline immunodeficiency virus: a concise review. Front Biosci. 2004;9:370-7 pubmed
  26. Vahlenkamp T, Bull M, Dow J, Collisson E, Winslow B, Phadke A, et al. B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion. Vet Immunol Immunopathol. 2004;98:203-14 pubmed
  27. D Cruz O, Waurzyniak B, Uckun F. Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats. Antimicrob Agents Chemother. 2004;48:1082-8 pubmed
  28. Weaver C, Burgess S, Nelson P, Wilkinson M, Ryan P, Nail C, et al. Placental immunopathology and pregnancy failure in the FIV-infected cat. Placenta. 2005;26:138-47 pubmed
    ..Therefore, increased placental Th1 cytokine expression was associated with pregnancy failure in the FIV-infected cat...
  29. Willett B, McMonagle E, Logan N, Spiller O, Schneider P, Hosie M. Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand. J Virol. 2007;81:9665-79 pubmed publisher
    ..In contrast, GL8, CPG, and NCSU were relatively refractory to inhibition by both 7D6 and CD134L and, accordingly, may have a higher-affinity interaction with CD134, permitting infection of cells where CD134 levels are limiting...
  30. Cattori V, Tandon R, Pepin A, Lutz H, Hofmann Lehmann R. Rapid detection of feline leukemia virus provirus integration into feline genomic DNA. Mol Cell Probes. 2006;20:172-81 pubmed
  31. Phadke A, de la Concha Bermejillo A, Wolf A, Andersen P, Baladandayuthapani V, Collisson E. Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B. Vet Microbiol. 2006;115:64-76 pubmed
    ..This decrease in the ratio was accompanied by a sharp and temporal decline in the absolute CD4(+) T cells and a slight increase in the absolute CD8(+) T cell numbers with a dramatic expansion of cells with CD8beta(low) chain expression...
  32. Kolenda Roberts H, Kuhnt L, Jennings R, Mergia A, Gengozian N, Johnson C. Immunopathogenesis of feline immunodeficiency virus infection in the fetal and neonatal cat. Front Biosci. 2007;12:3668-82 pubmed
  33. Dunham S, Bruce J, Mackay S, Golder M, Jarrett O, Neil J. Limited efficacy of an inactivated feline immunodeficiency virus vaccine. Vet Rec. 2006;158:561-2 pubmed
  34. Bisset L, Lutz H, Böni J, Hofmann Lehmann R, Luthy R, Schupbach J. Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication. Antiviral Res. 2002;53:35-45 pubmed
    ..However, in contrast to its effect on HIV replication, the ribonucleotide reductase inhibitor hydroxyurea (HU) is unable to effectively control in vitro FIV replication...
  35. Giannecchini S, Pistello M, Isola P, Matteucci D, Mazzetti P, Freer G, et al. Role of Env in resistance of feline immunodeficiency virus (FIV)-infected cats to superinfection by a second FIV strain as determined by using a chimeric virus. J Virol. 2007;81:10474-85 pubmed publisher
    ..Furthermore, complete protection and the presence of measurable neutralizing antibodies capable of blocking the second virus in vitro were not associated...
  36. Burkhard M, Dean G. Transmission and immunopathogenesis of FIV in cats as a model for HIV. Curr HIV Res. 2003;1:15-29 pubmed
    ..This review will encompass areas specific to transmission and immunopathogenesis...
  37. McDonnel S, Sparger E, Luciw P, Murphy B. Transcriptional regulation of latent feline immunodeficiency virus in peripheral CD4+ T-lymphocytes. Viruses. 2012;4:878-88 pubmed publisher
    ..Thus, the FIV/cat model may offer insights into in vivo mechanisms of HIV latency and provides a unique opportunity to test novel therapeutic interventions aimed at eradicating latent virus...
  38. Steinrigl A, Klein D. Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics. J Gen Virol. 2003;84:1301-7 pubmed
    ..The highly coincident results point to the existence of extensive virus variation with the presence of at least two highly divergent subtypes of FIV in Austria and Germany...
  39. Baxter K, Levy J, Edinboro C, Vaden S, Tompkins M. Renal disease in cats infected with feline immunodeficiency virus. J Vet Intern Med. 2012;26:238-43 pubmed publisher
    ..Renal disease is the 4th most common cause of death associated with HIV infection...
  40. Ostrowski S, van Vuuren M, Lenain D, Durand A. A serologic survey of wild felids from central west Saudi Arabia. J Wildl Dis. 2003;39:696-701 pubmed
    ..We recorded the first case of FeLV antigenemia in a wild sand cat. Positive results to FIV/PLV in wildcats and feral cats confirmed the occurrence of a feline lentivirus in the sampled population...
  41. Hartmann K. Clinical aspects of feline immunodeficiency and feline leukemia virus infection. Vet Immunol Immunopathol. 2011;143:190-201 pubmed publisher
    ..Today, FeLV is less important as a deadly infectious agent as in the last 20 years prevalence has been decreasing in most countries...
  42. Gómez N, Castillo V, Gisbert M, Pisano P, Mira G, Fontanals A, et al. Immune-endocrine interactions in treated and untreated cats naturally infected with FIV. Vet Immunol Immunopathol. 2011;143:332-7 pubmed publisher
    ..01). In summary, Zidovudine treatment appeared to contribute to the normalization of both the adrenal and thyroid axes. This effect could be attributed to the decrease observed in VL, resulting in a change in cytokine patterns...
  43. Vahlenkamp T, Tompkins M, Tompkins W. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells. J Immunol. 2004;172:4752-61 pubmed
    ..1, B7.2, and CTLA4. These FIV-activated, anergic, immunosuppressive CD25(+)CTLA4(+)B7(+)CD4(+) Treg-like cells may contribute to the progressive loss of T cell immune function that is characteristic of FIV infection...
  44. Hayward J, Rodrigo A. Recombination in feline immunodeficiency virus from feral and companion domestic cats. Virol J. 2008;5:76 pubmed publisher
    ..We investigated recombination in Feline Immunodeficiency Virus from naturally-infected New Zealand domestic cats (Felis catus) by sequencing regions of the gag, pol and env genes...
  45. Burkhard M, Mathiason C, Bowdre T, Hoover E. Feline immunodeficiency virus Gag- and Env-specific immune responses after vaginal versus intravenous infection. AIDS Res Hum Retroviruses. 2001;17:1767-78 pubmed
  46. Terwee J, Yactor J, Sondgeroth K, Vandewoude S. Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity. J Virol. 2005;79:2797-806 pubmed
    ..Mechanisms underlying this observation will provide clues to containment of immunodeficiency disease and could prompt reexamination of vaccine-induced immunity against human immunodeficiency virus and other lentiviruses...
  47. Willett B, Hosie M. Chemokine receptors and co-stimulatory molecules: unravelling feline immunodeficiency virus infection. Vet Immunol Immunopathol. 2008;123:56-64 pubmed publisher
    ..It is these early viruses that may be transmitted and should be considered as candidates for the development of vaccine regimes and novel therapeutic agents...
  48. Uckun F, Chen C, Samuel P, Pendergrass S, Venkatachalam T, Waurzyniak B, et al. In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats. Antimicrob Agents Chemother. 2003;47:1233-40 pubmed
  49. Scott V, Burgess S, Shack L, Lockett N, Coats K. Expression of CD134 and CXCR4 mRNA in term placentas from FIV-infected and control cats. Vet Immunol Immunopathol. 2008;123:90-6 pubmed publisher
    ..Thus, it appears that cells expressing these receptors may play a role in pregnancy maintenance...
  50. Pistello M, Matteucci D, Bonci F, Isola P, Mazzetti P, Zaccaro L, et al. AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine. J Virol. 2003;77:10740-50 pubmed
    ..Field studies may provide answers to some of the existing safety concerns surrounding attenuated AIDS vaccines in humans...
  51. Reggeti F, Bienzle D. Alloimmunity does not protect from challenge with the feline immunodeficiency virus. Vet Immunol Immunopathol. 2008;124:152-62 pubmed publisher
    ..Plasma viral load was not significantly different between groups of cats (p=0.204). These results suggest that immunization of cats with allogeneic DC does not induce protective immunity against FIV infection...
  52. Mizukoshi F, Baba K, Goto Y, Setoguchi A, Fujino Y, Ohno K, et al. Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein. Vet Microbiol. 2009;136:155-9 pubmed publisher
    ..FIV-N36, FIV-C35EK2, and FIV-C35EK3 did not show any apparent inhibitory effect. These results indicated that the newly developed membrane fusion inhibitors could facilitate the development of novel anti-lentiviral chemotherapies...
  53. Bandecchi P, Dell Omodarme M, Magi M, Palamidessi A, Prati M. Feline leukaemia virus (FeLV) and feline immunodeficiency virus infections in cats in the Pisa district of Tuscany, and attempts to control FeLV infection in a colony of domestic cats by vaccination. Vet Rec. 2006;158:555-7 pubmed