lentivirus infections

Summary

Summary: Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.

Top Publications

  1. Tasker S, Caney S, Day M, Dean R, Helps C, Knowles T, et al. Effect of chronic feline immunodeficiency infection, and efficacy of marbofloxacin treatment, on 'Candidatus Mycoplasma haemominutum' infection. Microbes Infect. 2006;8:653-61 pubmed
    ..This study documents, for the first time, the infection kinetics and antibiotic responsiveness of 'Candidatus M. haemominutum' infection...
  2. Synge B, Ritchie C. Elimination of small ruminant lentivirus infection from sheep flocks and goat herds aided by health schemes in Great Britain. Vet Rec. 2010;167:739-43 pubmed publisher
    ..A strategy was devised to interpret the ELISA results depending upon the prevalence of infection at the time. Eighteen of the 33 flocks/herds (54.5 per cent) that had introductions of infection also owned non-accredited stock...
  3. Brinkhof J, Moll L, van Maanen C, Houwers D. Use of serology and polymerase chain reaction for the rapid eradication of small ruminant lentivirus infections from a sheep flock: a case report. Res Vet Sci. 2010;88:41-3 pubmed publisher
    ..PCR also saved two lambs from being culled; they were sero-positive probably due to maternal antibodies, but not infected...
  4. Pistello M, Matteucci D, Giannecchini S, Bonci F, Sichi O, Presciuttini S, et al. Evolution of two amino acid positions governing broad neutralization resistance in a strain of feline immunodeficiency virus over 7 years of persistence in cats. Clin Diagn Lab Immunol. 2003;10:1109-16 pubmed
    ..Evidence that evolution at the BNR-governing positions was accompanied, and possibly driven, by changes in the antigenic makeup of the viral surface brought about by the mutations at such positions is also presented...
  5. White S, Mousel M, Herrmann Hoesing L, Reynolds J, Leymaster K, Neibergs H, et al. Genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus. PLoS ONE. 2012;7:e47829 pubmed publisher
    ..A recent study identified TMEM154 variants in OvLV susceptibility. The objective here was to identify additional loci associated with odds and/or control of OvLV infection...
  6. Brennan G, Podell M, Wack R, Kraft S, Troyer J, Bielefeldt Ohmann H, et al. Neurologic disease in captive lions (Panthera leo) with low-titer lion lentivirus infection. J Clin Microbiol. 2006;44:4345-52 pubmed
  7. Pisoni G, Quasso A, Moroni P. Phylogenetic analysis of small-ruminant lentivirus subtype B1 in mixed flocks: evidence for natural transmission from goats to sheep. Virology. 2005;339:147-52 pubmed
    ..This implies that SRLV control programs targeting only sheep or goats can no longer be proposed (based on a putative species specificity of the SRLV subtype B1)...
  8. Brinkhof J, van Maanen C, Wigger R, Peterson K, Houwers D. Specific detection of small ruminant lentiviral nucleic acid sequences located in the proviral long terminal repeat and leader-gag regions using real-time polymerase chain reaction. J Virol Methods. 2008;147:338-44 pubmed
    ..Real-time PCR testing, especially the application of oligonucleotides for priming the leader-gag region appeared promising in detecting SRLV specific proviral DNA in blood samples from both sheep and goats...
  9. Ignacio G, Nordone S, Howard K, Dean G. Toll-like receptor expression in feline lymphoid tissues. Vet Immunol Immunopathol. 2005;106:229-37 pubmed publisher

More Information

Publications62

  1. Ali Al Ahmad M, Fieni F, Martignat L, Chatagnon G, Baril G, Bouvier F, et al. Proviral DNA of caprine arthritis encephalitis virus (CAEV) is detected in cumulus oophorus cells but not in oocytes from naturally infected goats. Theriogenology. 2005;64:1656-66 pubmed
  2. Shah C, Böni J, Huder J, Vogt H, Mühlherr J, Zanoni R, et al. Phylogenetic analysis and reclassification of caprine and ovine lentiviruses based on 104 new isolates: evidence for regular sheep-to-goat transmission and worldwide propagation through livestock trade. Virology. 2004;319:12-26 pubmed
    ..Furthermore, infection of goats by subtypes A3 or A4 was significantly associated with documented contact with sheep, which also harbor these subtypes, thus indicating regularly occurring sheep-to-goat transmission...
  3. Lamara A, Fieni F, Mselli Lakhal L, Chatagnon G, Bruyas J, Tainturier D, et al. Early embryonic cells from in vivo-produced goat embryos transmit the caprine arthritis-encephalitis virus (CAEV). Theriogenology. 2002;58:1153-63 pubmed
    ..The absence of interactions between ZP-intact embryos and CAEV in vitro suggests that the ZP is an efficient protective embryo barrier...
  4. Ramirez H, Glaria I, de Andrés X, Martinez H, Hernandez M, Reina R, et al. Recombinant small ruminant lentivirus subtype B1 in goats and sheep of imported breeds in Mexico. Vet J. 2011;190:169-72 pubmed publisher
  5. Cheevers W, Snekvik K, Trujillo J, Kumpula McWhirter N, Pretty On Top K, Knowles D. Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis. Virology. 2003;306:116-25 pubmed
    ..Goats receiving prime-boost vaccination with CAEV env plasmids and SU-FIA became infected but suppressed postchallenge virus replication, provirus loads in lymph node, and development of arthritis for at least 84 weeks...
  6. Johnston J, Power C. Feline immunodeficiency virus xenoinfection: the role of chemokine receptors and envelope diversity. J Virol. 2002;76:3626-36 pubmed
  7. Gil A, Rola M, Kuzmak J. Application of PCR technique in diagnosis of small ruminant lentivirus infection in sheep and goats. Pol J Vet Sci. 2006;9:213-7 pubmed
    ..In conclusion, the data demonstrated that combinations of both ELISA and PCR might afford optimal detection of SRLVs infection...
  8. Sanchez A, Contreras A, Corrales J, Marco J. Relationships between infection with caprine arthritis encephalitis virus, intramammary bacterial infection and somatic cell counts in dairy goats. Vet Rec. 2001;148:711-4 pubmed
    ..There was a significant increase in somatic cell counts due to bacterial intramammary infection (P<0.01) in the seronegative goats, but this effect was not present in the seropositive animals...
  9. Pisoni G, Bertoni G, Boettcher P, Ponti W, Moroni P. Phylogenetic analysis of the gag region encoding the matrix protein of small ruminant lentiviruses: comparative analysis and molecular epidemiological applications. Virus Res. 2006;116:159-67 pubmed
    ..Finally, this study shows that the MA region is suitable for phylogenetic studies and may be applied to monitor SRLV eradication programs...
  10. Vandewoude S, Apetrei C. Going wild: lessons from naturally occurring T-lymphotropic lentiviruses. Clin Microbiol Rev. 2006;19:728-62 pubmed
    ..This comparison of consistent patterns in lentivirus biology will expose new directions for scientific inquiry for understanding the basis for virulence versus avirulence...
  11. Broughton Neiswanger L, White S, Knowles D, Mousel M, Lewis G, Herndon D, et al. Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: a molecular epidemiology study. Infect Genet Evol. 2010;10:998-1007 pubmed publisher
    ..Accurately defining the routes of OPPV transmission provides critical epidemiological data supporting management intended to reduce flock transmission and viral dose...
  12. Herrmann Hoesing L, Broughton Neiswanger L, Gouine K, White S, Mousel M, Lewis G, et al. Evaluation of a caprine arthritis-encephalitis virus/maedi-visna virus indirect enzyme-linked immunosorbent assay in the serological diagnosis of ovine progressive pneumonia virus in U.S. sheep. Clin Vaccine Immunol. 2010;17:307-10 pubmed publisher
    ..The sensitivity and the specificity were 86.0% (+ or - 5.8%) and 95.9% (+ or - 2.9%), respectively. The iELISA format and phylogenetic differences based on the MVV gag sequence contribute to the reduced sensitivity...
  13. Brown M, Munkhtsog B, Troyer J, Ross S, Sellers R, Fine A, et al. Feline immunodeficiency virus (FIV) in wild Pallas' cats. Vet Immunol Immunopathol. 2010;134:90-5 pubmed publisher
    ..Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIV(Oma) causes immune depletion in its' native host. ..
  14. Grego E, Lacerenza D, Arias R, Profiti M, Rosati S. Serological characterization of the new genotype E of small ruminant lentivirus in Roccaverano goat flocks. Vet Res Commun. 2009;33 Suppl 1:137-40 pubmed publisher
    ..The results clearly indicate that a strain specific antigen is required to correctly identify animals infected with different genotypes...
  15. Giammarioli M, Bazzucchi M, Puggioni G, Brajon G, Dei Giudici S, Taccori F, et al. Phylogenetic analysis of small ruminant lentivirus (SRLV) in Italian flocks reveals the existence of novel genetic subtypes. Virus Genes. 2011;43:380-4 pubmed publisher
    ..These results revealed a marked diversity among Italian field SRLV strains which might reflect the absence of any systematic control measures...
  16. Blacklaws B. Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus. Comp Immunol Microbiol Infect Dis. 2012;35:259-69 pubmed publisher
    ..This review examines replication, immunity to and pathogenesis of these viruses and highlights major differences from and similarities to some of the other lentiviruses...
  17. Saman E, Van Eynde G, Lujan L, Extramiana B, Harkiss G, Tolari F, et al. A new sensitive serological assay for detection of lentivirus infections in small ruminants. Clin Diagn Lab Immunol. 1999;6:734-40 pubmed
    b>Lentivirus infections in small ruminants represent an economic problem affecting several European countries with important sheep-breeding industries...
  18. Zhang F, Hatziioannou T, Perez Caballero D, Derse D, Bieniasz P. Antiretroviral potential of human tripartite motif-5 and related proteins. Virology. 2006;353:396-409 pubmed
    ..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins...
  19. Mselli Lakhal L, Guiguen F, Fornazero C, Favier C, Durand J, Grezel D, et al. Immortalized goat milk epithelial cell lines replicate CAEV at high level. Vet Res. 2001;32:429-40 pubmed
    ..On an other hand, these cell lines can be used to study their role in virus transmission and pathogenesis...
  20. de Andrés X, Ramirez H, Bertolotti L, San Roman B, Glaria I, Crespo H, et al. An insight into a combination of ELISA strategies to diagnose small ruminant lentivirus infections. Vet Immunol Immunopathol. 2013;152:277-88 pubmed publisher
    ..The use of particular peptide ELISAs and standard tests individually or combined may be useful in the different areas under study, to determine disease progression, diagnose/type infection and prevent its spread...
  21. Hosie M, Flynn J, Rigby M, Cannon C, Dunsford T, Mackay N, et al. DNA vaccination affords significant protection against feline immunodeficiency virus infection without inducing detectable antiviral antibodies. J Virol. 1998;72:7310-9 pubmed
    ..These findings demonstrate that DNA vaccination can elicit protection against lentivirus infection in the absence of a serological response and suggest the need to reconsider efficacy criteria for lentivirus vaccines...
  22. Crespo H, Jáuregui P, Glaria I, Sanjosé L, Polledo L, García Marín J, et al. Mannose receptor may be involved in small ruminant lentivirus pathogenesis. Vet Res. 2012;43:43 pubmed publisher
    ..The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis...
  23. Herrmann Hoesing L. Diagnostic assays used to control small ruminant lentiviruses. J Vet Diagn Invest. 2010;22:843-55 pubmed
    ..In addition, small ruminant genomics may help with establishing genetic markers of SRLV infection and disease, which could also aid eradication or reduction of SRLVs from herds and flocks throughout the world...
  24. Bertolotti L, Mazzei M, Puggioni G, Carrozza M, Dei Giudici S, Muz D, et al. Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin. J Gen Virol. 2011;92:1923-9 pubmed publisher
  25. Paillot R, Richard S, Bloas F, Piras F, Poulet H, Brunet S, et al. Toward a detailed characterization of feline immunodeficiency virus-specific T cell immune responses and mediated immune disorders. Vet Immunol Immunopathol. 2005;106:1-14 pubmed
    ..Interestingly, this study confirmed the strong similarity between FIV and HIV pathogenesis...
  26. Nishimura Y, Sadjadpour R, Mattapallil J, Igarashi T, Lee W, Buckler White A, et al. High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections. Proc Natl Acad Sci U S A. 2009;106:8015-20 pubmed publisher
    ..Prompt and sustained interventions are therefore required to block the rapid systemic dissemination of virus and prevent an otherwise fatal clinical outcome...
  27. Cheevers W, Beyer J, Hotzel I. Plasmid DNA encoding caprine interferon gamma inhibits antibody response to caprine arthritis-encephalitis virus (CAEV) surface protein encoded by a co-administered plasmid expressing CAEV env and tat genes. Vaccine. 2001;19:3209-15 pubmed
    ..Results indicate that synergistic effects of CAEV Tat and IFNgamma suppress the primary adaptive B cell response to plasmid encoded SU...
  28. Luengo C, Sanchez A, Corrales J, Fernandez C, Contreras A. Influence of intramammary infection and non-infection factors on somatic cell counts in dairy goats. J Dairy Res. 2004;71:169-74 pubmed
    ..The influence of all these factors should be taken into account in the establishment of more reliable diagnostic SCC thresholds for IMI...
  29. Blacklaws B, Berriatua E, Torsteinsdottir S, Watt N, de Andres D, Klein D, et al. Transmission of small ruminant lentiviruses. Vet Microbiol. 2004;101:199-208 pubmed
    ..However, such transmission has not been demonstrated to date. The application of control measures based on this information allows more efficient strategies to be developed which will reduce the rate of transmission...
  30. Vandewoude S, Hageman C, O Brien S, Hoover E. Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus. J Acquir Immune Defic Syndr. 2002;29:1-10 pubmed
  31. Angelopoulou K, Karanikolaou K, Papanastasopoulou M, Koumpati Artopiou M, Vlemmas I, Papadopoulos O, et al. First partial characterisation of small ruminant lentiviruses from Greece. Vet Microbiol. 2005;109:1-9 pubmed
    ..Phylogenetic analysis suggested that Greek strains segregate into a unique group, separate from, but related to, other ovine prototype sequences...
  32. Angelopoulou K, Poutahidis T, Brellou G, Greenland T, Vlemmas I. A deletion in the R region of long terminal repeats in small ruminant lentiviruses is associated with decreased pathology in the lung. Vet J. 2008;175:346-55 pubmed
  33. Mordasini F, Vogt H, Zahno M, Maeschli A, Nenci C, Zanoni R, et al. Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential. J Clin Microbiol. 2006;44:981-91 pubmed
    ..Under Swiss field conditions, the SU5 ELISA was shown to detect the majority of infected animals and, when applied in a molecular epidemiological context, to permit rapid phylogenetic classification of the infecting virus...
  34. Heaton M, Kalbfleisch T, Petrik D, Simpson B, Kijas J, Clawson M, et al. Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep. PLoS ONE. 2013;8:e55490 pubmed publisher
    ..e., diplotypes). The widespread distribution of highly-susceptible TMEM154 alleles suggests that genetic testing and selection may improve the health and productivity of infected flocks...
  35. Patton K, Bildfell R, Anderson M, Cebra C, Valentine B. Fatal Caprine arthritis encephalitis virus-like infection in 4 Rocky Mountain goats (Oreamnos americanus). J Vet Diagn Invest. 2012;24:392-6 pubmed publisher
  36. Pistello M, Moscardini M, Mazzetti P, Bonci F, Zaccaro L, Isola P, et al. Development of feline immunodeficiency virus ORF-A (tat) mutants: in vitro and in vivo characterization. Virology. 2002;298:84-95 pubmed
    ..One mutant underwent extensive ORF-A changes without, however, reverting to wild-type. Antiviral immune responses were feeble in all cats, suggesting that viral loads were too low to represent a sufficiently powerful antigenic stimulus...
  37. Kaba J, Strzałkowska N, Jozwik A, Krzyzewski J, Bagnicka E. Twelve-year cohort study on the influence of caprine arthritis-encephalitis virus infection on milk yield and composition. J Dairy Sci. 2012;95:1617-22 pubmed publisher
    ..40% vs. 3.35%), fat (3.69% vs. 3.54%), and lactose (4.30% vs. 4.25%) than the milk of infected goats. Even though these differences were highly significant, they were small when expressed numerically...
  38. Morin T, Guiguen F, Bouzar B, Villet S, Greenland T, Grezel D, et al. Clearance of a productive lentivirus infection in calves experimentally inoculated with caprine arthritis-encephalitis virus. J Virol. 2003;77:6430-7 pubmed
    ..the demonstration of a natural clearance of lentivirus infection following experimental inoculation of a nonnatural host, enabling perspectives of development of new potential vaccine strategies to fight against lentivirus infections.
  39. Mikkelsen S, Reckling S, Egan E, Dean G. In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus. Virology. 2010;403:163-72 pubmed publisher
    ..We propose that short-term in vivo Treg cell depletion during chronic HIV-1 infection could provide a window of opportunity for therapeutic vaccination in individuals with controlled viral replication...
  40. Cortez Romero C, Fieni F, Russo P, Pepin M, Roux C, Pellerin J. Presence of Maedi Visna virus (MVV)-proviral DNA in the genital tissues of naturally infected ewes. Reprod Domest Anim. 2011;46:e1-6 pubmed publisher
    ..This suggests that there is a risk of vertical and/or horizontal transmission of MVV during embryo transfer from embryos produced in vivo or in vitro...
  41. Kraase M, Sloan R, Klein D, Logan N, McMonagle L, Biek R, et al. Feline immunodeficiency virus env gene evolution in experimentally infected cats. Vet Immunol Immunopathol. 2010;134:96-106 pubmed publisher
    ..Therefore these results indicate that the FIV env gene evolves during the course of infection, giving rise to variants that resist neutralization and likely lead to disease progression...
  42. Vandewoude S, Troyer J, Poss M. Restrictions to cross-species transmission of lentiviral infection gleaned from studies of FIV. Vet Immunol Immunopathol. 2010;134:25-32 pubmed publisher
    ..Studies of naturally occurring SIV and innate host restriction systems suggest these same two mechanisms are significant factors inhibiting widespread cross-species transmission of lentiviruses among primate species as well...
  43. Yao X, Su Y, Liu C, Tan J, Liu L, Geng Y, et al. Establishment of an indicator cell line for monitoring bovine immunodeficiency virus infection and inhibitor susceptibility. J Virol Methods. 2010;163:25-30 pubmed publisher
    ..The BIV indicator cell line could also be used for the evaluation of the inhibitory effect of antiviral agents. The fusion inhibition effect of the heptad repeat 2 region of the BIV envelope protein could also be quantified...
  44. Rosati S, Profiti M, Lorenzetti R, Bandecchi P, Mannelli A, Ortoffi M, et al. Development of recombinant capsid antigen/transmembrane epitope fusion proteins for serological diagnosis of animal lentivirus infections. J Virol Methods. 2004;121:73-8 pubmed
    ..The detection of viral antibody response represents a practical diagnostic approach in all lentivirus infections since they remain detectable long life...
  45. Reina R, Mora M, Glaria I, García I, Solano C, Lujan L, et al. Molecular characterization and phylogenetic study of Maedi Visna and Caprine Arthritis Encephalitis viral sequences in sheep and goats from Spain. Virus Res. 2006;121:189-98 pubmed
    ..This suggests that there is heterogeneity at the primer binding site among Spanish SRLV sequences. It also illustrates the need to develop diagnostic tests that are sensitive in local breeds...
  46. Reina R, Glaria I, Cianca S, Crespo H, de Andrés X, Goñi C, et al. Use of small ruminant lentivirus-infected rams for artificial insemination. Vet J. 2011;189:106-7 pubmed publisher
    ..These preliminary findings suggest that semen from SRLV-infected rams could be used for AI without the risk of transmitting virus to susceptible ewes or their lambs. Further larger studies will be required to confirm this finding...
  47. Leitner G, Krifucks O, Weisblit L, Lavi Y, Bernstein S, Merin U. The effect of caprine arthritis encephalitis virus infection on production in goats. Vet J. 2010;183:328-31 pubmed publisher
    ..This finding could be attributed to lateral virus transmission from seropositive to seronegative kids because of lack of segregation within the flock...
  48. Reina R, Grego E, Bertolotti L, De Meneghi D, Rosati S. Genome analysis of small-ruminant lentivirus genotype E: a caprine lentivirus with natural deletions of the dUTPase subunit, vpr-like accessory gene, and 70-base-pair repeat of the U3 region. J Virol. 2009;83:1152-5 pubmed publisher
    ..Since a reduced viral load and/or disease progression was observed for viruses with artificially deleted dUTPase and vpr-like genes, it is proposed that this viral cluster be designated a low-pathogenicity caprine lentivirus...
  49. Pisoni G, Moroni P, Turin L, Bertoni G. Compartmentalization of small ruminant lentivirus between blood and colostrum in infected goats. Virology. 2007;369:119-30 pubmed
    ..The compartmentalization of SRLV between peripheral blood and colostrum indicates that lactogenic transmission may involve specific viruses not present in the proviral populations circulating in the blood...
  50. Mselli Lakhal L, Guiguen F, Greenland T, Mornex J, Chebloune Y. In vitro cross-species infections using a caprine arthritis encephalitis lentivirus carrying the GFP marker gene. J Virol Methods. 2007;143:11-5 pubmed
    ..The bovine cell lines MDBK and GBK were found to be sensitive to infection while the human cell lines Hela, A431 and THP-1 were not. The pK2EGFPH vector should prove useful in studies of CAEV tropism both in vitro and in vivo...
  51. St Louis M, Cojocariu M, Archambault D. The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses. Anim Health Res Rev. 2004;5:125-43 pubmed
    ..This manuscript aims to review biological and, more particularly, molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins, in comparison with those of other lentiviruses...
  52. Peterson K, Chesebro B. Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections. Curr Top Microbiol Immunol. 2006;303:67-95 pubmed
    ..Finally, various mechanisms are presented by which tumor necrosis factor (TNF) and several chemokines may alter the pathogenesis of retrovirus infection of the CNS...
  53. Ali Al Ahmad M, Fieni F, Guiguen F, Larrat M, Pellerin J, Roux C, et al. Cultured early goat embryos and cells are susceptible to infection with caprine encephalitis virus. Virology. 2006;353:307-15 pubmed
    ..All of these results clearly demonstrate that caprine early embryonic cells are susceptible to infection with CAEV and that infection with this virus is productive...