htlv i infections

Summary

Summary: Diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 1.

Top Publications

  1. Norrgren H, Bamba S, Larsen O, da Silva Z, Aaby P, Koivula T, et al. Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis. J Acquir Immune Defic Syndr. 2008;48:607-10 pubmed publisher
    ..Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB)...
  2. Asquith B, Bangham C. How does HTLV-I persist despite a strong cell-mediated immune response?. Trends Immunol. 2008;29:4-11 pubmed
    ..We develop a model to describe how these factors interact to enable viral persistence...
  3. Peloponese J, Kinjo T, Jeang K. Human T-cell leukemia virus type 1 Tax and cellular transformation. Int J Hematol. 2007;86:101-6 pubmed
    ..In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis...
  4. Tortevoye P, Tuppin P, Carles G, Peneau C, Gessain A. Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana. Am J Trop Med Hyg. 2005;73:560-5 pubmed
    ..While HTLV-I, which is highly endemic in groups of African origin, showed a slight decrease over time in a suspected cohort effect, HIV-1 spread rapidly in an epidemic mode, especially in the groups of the lowest socioeconomic levels...
  5. Yamano Y, Takenouchi N, Li H, Tomaru U, Yao K, Grant C, et al. Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. J Clin Invest. 2005;115:1361-8 pubmed
    ..These results suggest that direct human retroviral infection of CD4(+)CD25(+) T cells may be associated with the pathogenesis of HTLV-I-associated neurologic disease...
  6. Yakova M, Lezin A, Dantin F, Lagathu G, Olindo S, Jean Baptiste G, et al. Increased proviral load in HTLV-1-infected patients with rheumatoid arthritis or connective tissue disease. Retrovirology. 2005;2:4 pubmed
    ..In the present study, we evaluated the proviral load in a cohort of HTLV-1-infected patients with arthritic conditions...
  7. Taylor G, Bodeus M, Courtois F, Pauli G, Del Mistro A, Machuca A, et al. The seroepidemiology of human T-lymphotropic viruses: types I and II in Europe: a prospective study of pregnant women. J Acquir Immune Defic Syndr. 2005;38:104-9 pubmed
    ..Most data on the seroprevalence of HTLV-I and HTLV-II in Europe are from studies of low-risk blood donors or high-risk injection drug users (IDUs). Little is known about the general population...
  8. Asquith B, Zhang Y, Mosley A, de Lara C, Wallace D, Worth A, et al. In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A. 2007;104:8035-40 pubmed
    ..We suggest that there is persistent viral gene expression in vivo, which is necessary for the maintenance of the proviral load and determines HTLV-1-associated myelopathy/tropical spastic paraparesis risk...
  9. Olah I, Fukumori L, Montanheiro P, Vergara M, Smid J, Duarte A, et al. Patterns of in vitro lymphoproliferative responses among HTLV-1-infected subjects: upregulation by HTLV-1 during HIV-1 co-infection. Scand J Immunol. 2007;65:577-80 pubmed
    ..The singles HIV-1-infected group had decreased in vitro response. It appears that during co-infection, the HTLV-1 regulatory proteins overwhelm the action of HIV-1 regulatory proteins...

More Information

Publications62

  1. Cooper S, Van Der Loeff M, McConkey S, Cooper M, Sarge Njie R, Kaye S, et al. Neurological morbidity among human T-lymphotropic-virus-type-1-infected individuals in a rural West African population. J Neurol Neurosurg Psychiatry. 2009;80:66-8 pubmed publisher
    ..Community-based neurological data about human T lymphotropic virus type 1 (HTLV-1) morbidity in sub-Saharan Africa are scarce...
  2. Michaelsson J, Barbosa H, Jordan K, Chapman J, Brunialti M, Neto W, et al. The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. BMC Immunol. 2008;9:41 pubmed publisher
    ..The purpose of this study was to assess the frequency and phenotype of TReg cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation...
  3. Zehender G, Ebranati E, De Maddalena C, Gianelli E, Riva A, Rusconi S, et al. Description of a "trans-Saharan" strain of human T-lymphotropic virus type 1 in West Africa. J Acquir Immune Defic Syndr. 2008;47:269-73 pubmed
  4. Toulza F, Heaps A, Tanaka Y, Taylor G, Bangham C. High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood. 2008;111:5047-53 pubmed
    ..We propose that the frequency of CD4(+)FoxP3(+) Tax(-) T(regs) is one of the chief determinants of the efficiency of T cell-mediated immune control of HTLV-1...
  5. Usui T, Yanagihara K, Tsukasaki K, Murata K, Hasegawa H, Yamada Y, et al. Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells. Retrovirology. 2008;5:34 pubmed publisher
    ..HBZs consisting of non-spliced and spliced isoforms (HBZ-SI) are thought to be implicated in viral replication and T-cell proliferation but there is little evidence on the HBZ expression profile on a large scale...
  6. Verdonck K, Gonzalez E, Van Dooren S, Vandamme A, Vanham G, Gotuzzo E. Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect Dis. 2007;7:266-81 pubmed
    ..The understanding of the interaction between virus and host response has improved markedly, but there are still no clear surrogate markers for prognosis and there are few treatment options...
  7. Brites C, Sampalo J, Oliveira A. HIV/human T-cell lymphotropic virus coinfection revisited: impact on AIDS progression. AIDS Rev. 2009;11:8-16 pubmed
    ..Due to the limited available data, we need more, larger studies, designed to respond to the pending questions on the real significance of coinfection by these retroviruses...
  8. Asquith B, Mosley A, Heaps A, Tanaka Y, Taylor G, McLean A, et al. Quantification of the virus-host interaction in human T lymphotropic virus I infection. Retrovirology. 2005;2:75 pubmed
    ..The CD8+ cell response is thought to be a determinant of both HTLV-I proviral load and disease status but its effects can obscure other factors...
  9. Oh U, Grant C, Griffith C, Fugo K, Takenouchi N, Jacobson S. Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection. J Infect Dis. 2006;193:1557-66 pubmed
    ..These results suggest that impaired Foxp3 expression may contribute to the development of inflammatory disease during HTLV-1 infection...
  10. Mascarenhas R, Brodskyn C, Barbosa G, Clarencio J, Andrade Filho A, Figueiroa F, et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clin Vaccine Immunol. 2006;13:547-52 pubmed
    ..On the other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and increased proportion of CD4 T cells expressing CD45RO...
  11. Komori K, Hasegawa A, Kurihara K, Honda T, Yokozeki H, Masuda T, et al. Reduction of human T-cell leukemia virus type 1 (HTLV-1) proviral loads in rats orally infected with HTLV-1 by reimmunization with HTLV-1-infected cells. J Virol. 2006;80:7375-81 pubmed
  12. Ohshima K. Pathological features of diseases associated with human T-cell leukemia virus type I. Cancer Sci. 2007;98:772-8 pubmed
    ..To clarify the HTLV-I-associated diseases, it is important to understand the pathological variations...
  13. Jones K, Petrow Sadowski C, Huang Y, Bertolette D, Ruscetti F. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med. 2008;14:429-36 pubmed publisher
    ..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
  14. Marinho J, Galvao Castro B, Rodrigues L, Barreto M. Increased risk of tuberculosis with human T-lymphotropic virus-1 infection: a case-control study. J Acquir Immune Defic Syndr. 2005;40:625-8 pubmed
    ..To investigate whether infection with human T-lymphotropic virus type 1 (HTLV-1) increases the risk of tuberculosis...
  15. Holmgren B, da Silva Z, Vastrup P, Larsen O, Andersson S, Ravn H, et al. Mortality associated with HIV-1, HIV-2, and HTLV-I single and dual infections in a middle-aged and older population in Guinea-Bissau. Retrovirology. 2007;4:85 pubmed
    ..The present study compares mortality associated with HIV-1, HIV-2, and HTLV-I single and dual infections in individuals over 35 years of age within an urban community-based cohort in Guinea-Bissau...
  16. Ku S, Lee J, Lau J, Gurumurthy M, Ng R, Lwa S, et al. XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription. J Virol. 2008;82:4343-53 pubmed publisher
    ..Collectively, our study demonstrates a novel host-virus interaction between a cellular factor XBP-1 and transcriptional regulation of HTLV-1...
  17. Gatza M, Dayaram T, Marriott S. Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export. Retrovirology. 2007;4:95 pubmed
    ..Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins...
  18. Yoshida M. Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene. 2005;24:5931-7 pubmed
    ..The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also discussed briefly...
  19. Brites C, Oliveira A, Netto E. Coinfection with HIV and human T lymphotropic virus type 1: what is the real impact on HIV disease?. Clin Infect Dis. 2005;40:329-30; author reply 330-1 pubmed
  20. Casoli C, Pilotti E, Bertazzoni U. Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression. AIDS Rev. 2007;9:140-9 pubmed
    ..In conclusion, the long-term effects of HIV and HTLV coinfections are poorly understood and the mechanisms of dysregulation of cellular biosynthesis by HTLV that impact HIV disease progression remain elusive...
  21. Verdonck K, Gonzalez E, Henostroza G, Nabeta P, Llanos F, Cornejo H, et al. HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru. Int J Tuberc Lung Dis. 2007;11:1066-72 pubmed
    ..Tuberculosis (TB) and human T-lymphotropic virus 1 (HTLV-1) are frequent in Peru. The prevalence of HTLV-1 among Peruvian TB patients is unknown...
  22. Enose Akahata Y, Oh U, Grant C, Jacobson S. Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease. Blood. 2008;112:2400-10 pubmed publisher
    ..Despite lower viral expression than in CD4(+) T cells, HTLV-I-infected or -activated CD14(+) cells may be a heretofore important but under recognized reservoir particularly in HAM/TSP patients...
  23. Boxus M, Twizere J, Legros S, Dewulf J, Kettmann R, Willems L. The HTLV-1 Tax interactome. Retrovirology. 2008;5:76 pubmed publisher
    ..In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far...
  24. Roucoux D, Wang B, Smith D, Nass C, Smith J, Hutching S, et al. A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II. J Infect Dis. 2005;191:1490-7 pubmed
    ..Cross-sectional studies support sexual transmission of human T lymphotropic virus (HTLV)-I/II; however, prospective incidence data, particularly for HTLV-II, are limited...
  25. Bangham C, Osame M. Cellular immune response to HTLV-1. Oncogene. 2005;24:6035-46 pubmed
    ..With these experimental data, it is becoming possible to refine, parameterize and test mathematical models of the immune control of HTLV-1, which are a necessary part of an understanding of this complex dynamic system...
  26. Mosley A, Meekings K, McCarthy C, Shepherd D, Cerundolo V, Mazitschek R, et al. Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection. Blood. 2006;108:3801-7 pubmed
  27. Proietti F, Carneiro Proietti A, Catalan Soares B, Murphy E. Global epidemiology of HTLV-I infection and associated diseases. Oncogene. 2005;24:6058-68 pubmed
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of paramount importance...
  28. Giam C, Jeang K. HTLV-1 Tax and adult T-cell leukemia. Front Biosci. 2007;12:1496-507 pubmed
  29. Plancoulaine S, Gessain A, Tortevoye P, Boland Auge A, Vasilescu A, Matsuda F, et al. A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27. Hum Mol Genet. 2006;15:3306-12 pubmed
  30. Carvalho E, Da Fonseca Porto A. Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis. Parasite Immunol. 2004;26:487-97 pubmed
  31. Nasr R, Chiari E, El Sabban M, Mahieux R, Kfoury Y, Abdulhay M, et al. Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation. Blood. 2006;107:4021-9 pubmed
    ..Thus, ubiquitylation and sumoylation of the same residues of Tax regulate 2 essential steps controlling NF-kappaB activation, demonstrating how these posttranslational modifications can cooperate to promote Tax-induced transformation...
  32. Xie L, Yamamoto B, Haoudi A, Semmes O, Green P. PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo. Blood. 2006;107:1980-8 pubmed
  33. Alefantis T, Jain P, Ahuja J, Mostoller K, Wigdahl B. HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease. J Biomed Sci. 2005;12:961-74 pubmed
    ..Finally, the secretion of Tax and the effects of extracellular Tax on HTLV-1 pathogenesis will be addressed...
  34. Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, et al. Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages. Cancer Sci. 2009;100:481-9 pubmed publisher
  35. Beilke M, Theall K, O Brien M, Clayton J, Benjamin S, Winsor E, et al. Clinical outcomes and disease progression among patients coinfected with HIV and human T lymphotropic virus types 1 and 2. Clin Infect Dis. 2004;39:256-63 pubmed
    ..In conclusion, HIV-HTLV-I/II coinfection may result in improved survival and delayed progression to AIDS, but this happens at the expense of an increased frequency of other of clinical complications...
  36. Hanon E, Goon P, Taylor G, Hasegawa H, Tanaka Y, Weber J, et al. High production of interferon gamma but not interleukin-2 by human T-lymphotropic virus type I-infected peripheral blood mononuclear cells. Blood. 2001;98:721-6 pubmed
    ..Such cells are capable of migration through peripheral tissues and could therefore contribute to the inflammation seen in diseases such as HTLV-I-associated myelopathy/tropical spastic paraparesis. (Blood. 2001;98:721-726)..
  37. Araujo A, Hall W. Human T-lymphotropic virus type II and neurological disease. Ann Neurol. 2004;56:10-9 pubmed
    ..In view of the many HTLV-II-infected individuals in urban areas of North America and Europe, neurologists should be aware of the potential clinical consequences of this infection...
  38. Edlich R, Hill L, Williams F. Global epidemic of human T-cell lymphotrophic virus type-I (HTLV-I): an update. J Long Term Eff Med Implants. 2003;13:127-40 pubmed
    ..Coinfection with HTLV-I and human immunodeficiency virus (HIV) has been shown to accelerate the progression of acquired immune deficiency syndrome (AIDS)...
  39. Porto A, Neva F, Bittencourt H, Lisboa W, Thompson R, Alcantara L, et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunol. 2001;23:503-7 pubmed
    ..Immunological responses such as these are important in the control of this helminthic infection...
  40. Murphy E, Wu Y, Ownby H, Smith J, Ruedy R, Thomson R, et al. Delayed hypersensitivity skin testing to mumps and Candida albicans antigens is normal in middle-aged HTLV-I- and-II-infected U.S. cohorts. AIDS Res Hum Retroviruses. 2001;17:1273-7 pubmed
    ..60, 95% CI 0.20-1.78), and 19% of HTLV-II (OR = 0.56, 95% CI 0.22-1.44). HTLV-I- and -II-infected persons appear to have intact delayed hypersensitivity skin test responses to mumps and Candida albicans antigens...
  41. Royer Leveau C, Mordelet E, Delebecque F, Gessain A, Charneau P, Ozden S. Efficient transfer of HTLV-1 tax gene in various primary and immortalized cells using a flap lentiviral vector. J Virol Methods. 2002;105:133-40 pubmed
    ..Therefore, this vector provides a useful tool for investigating the role of the Tax viral protein in the pathogenesis of diseases linked to HTLV-1 infection...
  42. Kamihira S, Dateki N, Sugahara K, Hayashi T, Harasawa H, Minami S, et al. Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Clin Lab Haematol. 2003;25:111-7 pubmed
    ..This result indicates that the detection of proviral load by(RT) PCR is sufficient and relevant to monitor the infected cell number in the PB and to evaluate the HTLV-1 pathologic status...
  43. Adjei A, Adiku T, Kumi P, Domfeh A. Human T-lymphotropic type-1 virus specific antibody detected in sera of HIV/AIDS patients in Ghana. Jpn J Infect Dis. 2003;56:57-9 pubmed
    ..Whether HTLV-1 is an underlying disease association or whether HTLV-1 plays some auxiliary role in the acquisition and progression of AIDS remains to be determined...
  44. Santos S, Porto A, Muniz A, de Jesus A, Magalhães E, Melo A, et al. Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers. BMC Infect Dis. 2004;4:7 pubmed
    ..In this study the immunological responses in HAM/TSP patients and in HTLV-I asymptomatic carriers were compared using several immunological assays to identify immunological markers associated with progression from infection to disease...
  45. Murphy E, Lee T, Chafets D, Nass C, Wang B, Loughlin K, et al. Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion. J Infect Dis. 2004;190:504-10 pubmed
  46. Zehender G, Colasante C, De Maddalena C, Bernini F, Savasi V, Persico T, et al. High prevalence of human T-lymphotropic virus type 1 (HTLV-1) in immigrant male-to-female transsexual sex workers with HIV-1 infection. J Med Virol. 2004;74:207-15 pubmed
    ..These results suggest the independent origin of each infection in the patient's birthplace. The data raise concerns about the further spread of HTLV infections mainly through the sexual route...
  47. Vine A, Heaps A, Kaftantzi L, Mosley A, Asquith B, Witkover A, et al. The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol. 2004;173:5121-9 pubmed
    ..We conclude that successful suppression of the HTLV-1 proviral load is associated with strong cytotoxic CD8+ lymphocyte activity in the peripheral blood...
  48. Nagai M, Osame M. Human T-cell lymphotropic virus type I and neurological diseases. J Neurovirol. 2003;9:228-35 pubmed
    ..Therefore, the immune response to HTLV-I probably contributes to the inflammatory process of the central nervous system lesions in HAM/TSP patients...
  49. Nishimura M, Maeda M, Yasunaga J, Kawakami H, Kaji R, Adachi A, et al. Influence of cytokine and mannose binding protein gene polymorphisms on human T-cell leukemia virus type I (hTLV-I) provirus load in HTLV-I asymptomatic carriers. Hum Immunol. 2003;64:453-7 pubmed
    ..These data suggest that inflammation or an active immune response may induce an increased amount of HTLV-I-infected T cells, leading to a high provirus load...
  50. Goon P, Hanon E, Igakura T, Tanaka Y, Weber J, Taylor G, et al. High frequencies of Th1-type CD4(+) T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. Blood. 2002;99:3335-41 pubmed
    ..High frequencies of activated HTLV-1-specific CD4(+) T cells of the Th1 phenotype might contribute to the initiation or pathogenesis of HAM/TSP and other HTLV-1-associated inflammatory diseases...
  51. Satoh M, Toma H, Sato Y, Takara M, Shiroma Y, Kiyuna S, et al. Reduced efficacy of treatment of strongyloidiasis in HTLV-I carriers related to enhanced expression of IFN-gamma and TGF-beta1. Clin Exp Immunol. 2002;127:354-9 pubmed
    ..01) and a lower cure rate (P < 0.01) compared with those who were negative for both cytokines. These results suggest that persistent infection with HTLV-I affected S. stercoralis-specific immunity and reduced therapeutic efficacy...
  52. Sonoda J, Koriyama C, Yamamoto S, Kozako T, Li H, Lema C, et al. HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. Cancer Sci. 2004;95:596-601 pubmed
    ..031). These results suggest that green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo...
  53. Lee T, Chafets D, Busch M, Murphy E. Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry. J Clin Virol. 2004;31:275-82 pubmed
    ..Human T-lymphotropic virus type II (HTLV-II) is associated with HAM/TSP and, in HIV coinfected patients only, rare cases of cutaneous T cell lymphoma. Proviral load may be important in the pathogenesis of HTLV-associated disease...