deltaretrovirus infections

Summary

Summary: Infections caused by the HTLV or BLV deltaretroviruses. They include human T-cell leukemia-lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED).

Top Publications

  1. Zheng H, Wolfe N, Sintasath D, Tamoufe U, LeBreton M, Djoko C, et al. Emergence of a novel and highly divergent HTLV-3 in a primate hunter in Cameroon. Virology. 2010;401:137-45 pubmed publisher
  2. Ferens W, Cobbold R, Hovde C. Intestinal Shiga toxin-producing Escherichia coli bacteria mitigate bovine leukemia virus infection in experimentally infected sheep. Infect Immun. 2006;74:2906-16 pubmed
    ..05). These results support the hypothesis that in ruminants, intestinal STEC bacteria have antiviral activity and mitigate BLV-induced disease...
  3. Courgnaud V, Van Dooren S, Liegeois F, Pourrut X, Abela B, Loul S, et al. Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis). J Virol. 2004;78:4700-9 pubmed
  4. Pomier C, Alcaraz M, Debacq C, Lançon A, Kerkhofs P, Willems L, et al. Early and transient reverse transcription during primary deltaretroviral infection of sheep. Retrovirology. 2008;5:16 pubmed publisher
    ..Primary infection of a new organism necessary involves allogenic cell infection and thus reverse transcription...
  5. Gabet A, Gessain A, Wattel E. High simian T-cell leukemia virus type 1 proviral loads combined with genetic stability as a result of cell-associated provirus replication in naturally infected, asymptomatic monkeys. Int J Cancer. 2003;107:74-83 pubmed
  6. Takemura T, Yamashita M, Shimada M, Ohkura S, Shotake T, Ikeda M, et al. High prevalence of simian T-lymphotropic virus type L in wild ethiopian baboons. J Virol. 2002;76:1642-8 pubmed
    ..Further studies are required to know if STLV-L is spreading into human populations...
  7. Slattery J, Franchini G, Gessain A. Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res. 1999;9:525-40 pubmed
    ..Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion...
  8. Mahieux R, Chappey C, Georges Courbot M, Dubreuil G, Mauclere P, Georges A, et al. Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D. J Virol. 1998;72:10316-22 pubmed
    ..Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently...
  9. Zrein M, Louwagie J, Boeykens H, Govers L, Hendrickx G, Bosman F, et al. Assessment of a new immunoassay for serological confirmation and discrimination of human T-cell lymphotropic virus infections. Clin Diagn Lab Immunol. 1998;5:45-9 pubmed
    ..Due to its enhanced specificity and sensitivity, the new assay not only improves the ability to confirm and discriminate HTLV infections but also eliminates the vast majority of WB-indeterminate and false-positive specimens...

More Information

Publications62

  1. Makuwa M, Souquiere S, Telfer P, Mouinga Ondeme A, Bourry O, Roques P. A New STLV-1 in a household pet Cercopithecus nictitans from Gabon. AIDS Res Hum Retroviruses. 2004;20:679-83 pubmed
    ..These data show that C. nictitans may be the natural carrier of two different molecular types of STLV, one related to STLV-3 and the other possibly one of the simian STLV type 1 counterparts of HTLV-1 subtype D...
  2. Graves L, Hennessy A, Sunderland N, Heffernan S, Thomson S. Incidence of lymphoma in a captive-bred colony of hamadryas baboons (Papio hamadryas). Aust Vet J. 2009;87:238-43 pubmed publisher
    ..To assess the incidence of lymphoma and wasting-related deaths in the National Baboon Colony of Australia and relate it to the presence of simian T-cell lymphotrophic virus 1 (STLV-1) infection...
  3. Van Dooren S, Verschoor E, Fagrouch Z, Vandamme A. Phylogeny of primate T lymphotropic virus type 1 (PTLV-1) including various new Asian and African non-human primate strains. Infect Genet Evol. 2007;7:374-81 pubmed
    ..Barbary macaques, not yet described to be STLV-infected, carry a relatively recent acquired, typical African STLV-1, giving us no clue on the phylogeographical origin of PTLV-1...
  4. Makuwa M, Souquiere S, Clifford S, Telfer P, Salle B, Bourry O, et al. Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts. AIDS Res Hum Retroviruses. 2004;20:1137-43 pubmed
    ..The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers...
  5. Sintasath D, Wolfe N, Zheng H, LeBreton M, Peeters M, Tamoufe U, et al. Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey. Retrovirology. 2009;6:97 pubmed publisher
    ..Our ability to obtain the complete viral genome from DBS also highlights further the utility of this method for molecular-based epidemiologic studies...
  6. Stevens H, Holterman L, Haaksma A, Jonker M, Heeney J. Lymphoproliferative disorders developing after transplantation and their relation to simian T-cell leukemia virus infection. Transpl Int. 1992;5 Suppl 1:S450-3 pubmed
    ..In conclusion, for the first time the oncogenic potential of STLV is identified in a rhesus monkey transplantation model. Moreover, the importance of screening blood and organ donors for HTLV-1 must be emphasized...
  7. Goldberg T, Sintasath D, Chapman C, Cameron K, Karesh W, Tang S, et al. Coinfection of Ugandan red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses. J Virol. 2009;83:11318-29 pubmed publisher
  8. Ishak R, Vallinoto A, Azevedo V, Ishak M. Epidemiological aspects of retrovirus (HTLV) infection among Indian populations in the Amazon Region of Brazil. Cad Saude Publica. 2003;19:901-14 pubmed
    ..HIV, the other human retrovirus, is still not prevalent among indigenous communities in the Brazilian Amazon, but these groups are also easy targets for the virus...
  9. Poiesz B, Poiesz M, Choi D. The human T-cell lymphoma/leukemia viruses. Cancer Invest. 2003;21:253-77 pubmed
    ..In the future, better screening and detection methods, along with new vaccines and therapies, may contribute to the increased prevention and control of HTLV infection and its associated diseases...
  10. Carneiro Proietti A, Catalan Soares B, Castro Costa C, Murphy E, Sabino E, Hisada M, et al. HTLV in the Americas: challenges and perspectives. Rev Panam Salud Publica. 2006;19:44-53 pubmed
    ..For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of vital importance. In the Americas this is especially important in the areas of high prevalence...
  11. Willems L. The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil). Retrovirology. 2009;6:77 pubmed publisher
    ..Exciting new findings were presented in these different fields, and the new advances have led to novel clinical trials. Here, highlights from this conference are summarized...
  12. Mahieux R, Pecon Slattery J, Chen G, Gessain A. Evolutionary inferences of novel simian T lymphotropic virus type 1 from wild-caught chacma (Papio ursinus) and olive baboons (Papio anubis). Virology. 1998;251:71-84 pubmed
    ..anubis, corroborates the hypothesis of cross-species transmissions of STLV-1 in the wild. Further, phylogenetic analyses indicate that the known HTLV-1 strains do not share a common origin with nonhuman primates STLV in South Africa...
  13. Leendertz F, Junglen S, Boesch C, Formenty P, Couacy Hymann E, Courgnaud V, et al. High variety of different simian T-cell leukemia virus type 1 strains in chimpanzees (Pan troglodytes verus) of the Taï National Park, Côte d'Ivoire. J Virol. 2004;78:4352-6 pubmed
  14. Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott S, et al. Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemia. Cancer Res. 2007;67:10638-41 pubmed
  15. Wolfe N, Heneine W, Carr J, Garcia A, Shanmugam V, Tamoufe U, et al. Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters. Proc Natl Acad Sci U S A. 2005;102:7994-9 pubmed
  16. Calattini S, Chevalier S, Duprez R, Bassot S, Froment A, Mahieux R, et al. Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa. Retrovirology. 2005;2:30 pubmed
  17. Sintasath D, Wolfe N, LeBreton M, Jia H, Garcia A, Le Doux Diffo J, et al. Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon. Emerg Infect Dis. 2009;15:175-84 pubmed
    ..Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations...
  18. Switzer W, Hewlett I, Aaron L, Wolfe N, Burke D, Heneine W. Serologic testing for human T-lymphotropic virus-3 and -4. Transfusion. 2006;46:1647-8 pubmed
  19. Van Dooren S, Shanmugam V, Bhullar V, Parekh B, Vandamme A, Heneine W, et al. Identification in gelada baboons (Theropithecus gelada) of a distinct simian T-cell lymphotropic virus type 3 with a broad range of Western blot reactivity. J Gen Virol. 2004;85:507-19 pubmed
  20. Calattini S, Betsem E, Bassot S, Chevalier S, Mahieux R, Froment A, et al. New strain of human T lymphotropic virus (HTLV) type 3 in a Pygmy from Cameroon with peculiar HTLV serologic results. J Infect Dis. 2009;199:561-4 pubmed publisher
    ..These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses...
  21. Gessain A, Mahieux R. [Epidemiology, origin and genetic diversity of HTLV-1 retrovirus and STLV-1 simian affiliated retrovirus]. Bull Soc Pathol Exot. 2000;93:163-71 pubmed
    ..g., the slave trade from Africa to the New World...
  22. Koralnik I, Boeri E, Saxinger W, Monico A, Fullen J, Gessain A, et al. Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains: evidence for interspecies transmission. J Virol. 1994;68:2693-707 pubmed
    ..Geographic concordance of divergent host species that harbor closely related viruses reinforces that physical feasibility for hypothesized interspecies virus transmission in the past and in the present...
  23. Hubbard G, Moné J, Allan J, Davis K, Leland M, Banks P, et al. Spontaneously generated non-Hodgkin's lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species). Lab Anim Sci. 1993;43:301-9 pubmed
    ..The lungs in 14 baboons had thickened pleuras, congestion,edema, and large tan to brown areas of consolidation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. Ibrahim F, de The G, Gessain A. Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia viru. J Virol. 1995;69:6980-93 pubmed
  25. Malik K, Even J, Karpas A. Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup. J Gen Virol. 1988;69 ( Pt 7):1695-710 pubmed publisher
    ..Analysis of defective proviral clones isolated from the same genomic library is also reported, and suggests a pattern of proviral sequence deletions during the biogenesis of defective proviruses...
  26. Meertens L, Shanmugam V, Gessain A, Beer B, Tooze Z, Heneine W, et al. A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria. J Gen Virol. 2003;84:2723-7 pubmed
  27. Akari H, Ono F, Sakakibara I, Takahashi H, Murayama Y, Hiyaoka A, et al. Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia. AIDS Res Hum Retroviruses. 1998;14:367-71 pubmed
    ..However, in the case of in vitro-transformed cell lines the expression pattern of the CD8 chains varied in individual monkeys. Thus, STLV-I may preferentially transform CD8+ (both alphaalpha+ and alphabeta+) T cells in AGMs...
  28. van Brussel M, Goubau P, Rousseau R, Desmyter J, Vandamme A. Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat. J Virol. 1997;71:5464-72 pubmed
    ..We conclude that STLV-PH969 has all the genes and genomic regions to suggest a replication cycle comparable to that of HTLV-1 and HTLV-2...
  29. Vandamme A, Van Laethem K, Liu H, van Brussel M, Delaporte E, de Castro Costa C, et al. Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology. J Med Virol. 1997;52:1-7 pubmed
    ..This new assay can identify otherwise undetected HTLV-I or HTLV-II infections and is a useful tool of screening for new types of HTLV among seroindeterminate samples...
  30. Voevodin A, Samilchuk E, Schatzl H, Boeri E, Franchini G. Interspecies transmission of macaque simian T-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma. J Virol. 1996;70:1633-9 pubmed
    ..Thus, interspecies transmission of STLV-1 from rhesus macaques (or closely related species) to baboons occurred at Sukhumi Primate Center. Most probably this event initiated the outbreak of lymphoma in Sukhumi baboons...
  31. Perzova R, Benz P, Abbott L, Welch C, Thomas A, El Ghoul R, et al. Short communication: no evidence of HTLV-3 and HTLV-4 infection in New York State subjects at risk for retroviral infection. AIDS Res Hum Retroviruses. 2010;26:1229-31 pubmed publisher
    ..Continued epidemiological studies are warranted to explore the worldwide prevalence rates and dissemination patterns of HTLV-3 and 4 infections, and their possible disease associations...
  32. Afonso P, Mekaouche M, Mortreux F, Toulza F, Moriceau A, Wattel E, et al. Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors. Blood. 2010;116:3802-8 pubmed publisher
    ..Such treatments may be useful to reduce the risk of HAM/TSP in asymptomatic carriers with a high PVL...
  33. Nerrienet E, Amouretti X, Müller Trutwin M, Poaty Mavoungou V, Bedjebaga I, Nguyen H, et al. Phylogenetic analysis of SIV and STLV type I in mandrills (Mandrillus sphinx): indications that intracolony transmissions are predominantly the result of male-to-male aggressive contacts. AIDS Res Hum Retroviruses. 1998;14:785-96 pubmed
  34. Liegeois F, Lafay B, Switzer W, Locatelli S, Mpoudi Ngole E, Loul S, et al. Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon. Virology. 2008;371:405-17 pubmed
    ..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
  35. Hawkes C. Is multiple sclerosis a sexually transmitted infection?. J Neurol Neurosurg Psychiatry. 2002;73:439-43 pubmed
    ..It is hoped this hypothesis might encourage a new direction of neurological research...
  36. Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, et al. HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol. 1988;23 Suppl:S143-50 pubmed
    ..The high immune response to HTLV-I seems to be an important genetic factor in the development of HAM...
  37. Murphy E, Jacobson S, Franchini G, Taylor G, Hanchard B, Morgan O, et al. International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials. Retrovirology. 2005;2:22 pubmed
  38. Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D. Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors. PLoS Pathog. 2010;6:e1000788 pubmed publisher
    ..In general, the dependence on cell-to-cell infection was determined by the virus, the effector and target cell types, and by the nature of the cell-cell interaction...
  39. Dorsey K, Moritz E, Steele W, Eder A, Stramer S. A comparison of human immunodeficiency virus, hepatitis C virus, hepatitis B virus, and human T-lymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010. Transfusion. 2013;53:1250-6 pubmed publisher
    ..However, there is little evidence of improved safety with directed donation when compared to volunteer donation...
  40. Miura M, Yasunaga J, Tanabe J, Sugata K, Zhao T, Ma G, et al. Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology. 2013;10:118 pubmed publisher
    ..However, the function of the regulatory and accessory genes of STLV-1 has not been analyzed in detail. In this study, STLV-1 in naturally infected Japanese macaques was analyzed...
  41. Hayase H. [Analysis of immune controlling CD4+CD25+ T cells in HTLV-1 transgenic rats]. Hokkaido Igaku Zasshi. 2004;79:505-15 pubmed
  42. Parrish S, Brown A, Chanbancherd P, Gettayacamin M, Parrish J. Transmission of STLV in a closed colony of macaques. Am J Primatol. 2004;63:103-9 pubmed
    ..Transmission by all routes was infrequent, as indicated by the overall seroprevalence of 3.3% (14 of 420 samples) after the colony had been closed for 11 years. Maternal-infant transmission appeared to be < 12%...
  43. Cesaire R, Kerob Bauchet B, Bourdonné O, Maier H, Amar K, Halbout P, et al. Evaluation of HTLV-I removal by filtration of blood cell components in a routine setting. Transfusion. 2004;44:42-8 pubmed
    ..WBC depletion by filtration may prevent the transmission of HTLV-I, which requires cell-to-cell contact. The removal of HTLV-I-infected cells in routinely filtered blood cell components was measured...
  44. Usui T, Konnai S, Tajima S, Watarai S, Aida Y, Ohashi K, et al. Protective effects of vaccination with bovine leukemia virus (BLV) Tax DNA against BLV infection in sheep. J Vet Med Sci. 2003;65:1201-5 pubmed
    ..These results suggested that Th1 type immune response induced by Tax DNA vaccine inhibited BLV propagation in vaccinated sheep at the early phase of infection...
  45. Lofters W, Campbell M, Gibbs W, Cheson B. 2'-Deoxycoformycin therapy in adult T-cell leukemia/lymphoma. Cancer. 1987;60:2605-8 pubmed
    ..As a single agent, DCF appears to have limited activity in advanced refractory/relapsed ATL. Studies in the future should explore DCF in combination with other cytotoxic agents as initial therapy in better-risk patients...
  46. Kurth R, Lower R, Lower J, Gelderblom H. [Retroviruses and the development of lymphoma]. Onkologie. 1987;10:186-94 pubmed
    ..HTLV-IV and LAV-2 are additional HIV-1 related strains and are supposed to cause AIDS as well. What is known about the pathogenicity of the human retrovirus strains will be discussed...
  47. Tagaya Y, Taniguchi Y, Naramura M, Okada M, Suzuki N, Kanamori H, et al. Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. Immunol Lett. 1987;15:221-8 pubmed
    ..In YT cells, the transcriptional initiation of the promoter of the IL-2-R gene was enhanced by ADF but not by IL-2. Production of ADF by HTLV-I(+) T-cell lines may be involved in the abnormal expression of IL-2-Rs on these cells...
  48. Schuetz A, Roback J. Towards the prevention of transfusion-transmitted infectious diseases. Expert Rev Anti Infect Ther. 2003;1:267-74 pubmed
    ..This review summarizes these advances in an historical context, describes new methodologies on the horizon, and discusses residual infectious risks associated with blood transfusion...
  49. Yu H, Fujita J, Higa F, Yamadori I, Hibiya K, Yara S, et al. Nonspecific interstitial pneumonia pattern as pulmonary involvement in human T-cell lymphotropic virus type 1 carriers. J Infect Chemother. 2009;15:284-7 pubmed publisher
    ..The present study demonstrates that the NSIP pattern is a significant pathological classification of interstitial pneumonia associated with HTLV-1 carriers...
  50. Tajima K, Kamura S, Ito S, Ito M, Nagatomo M, Kinoshita K, et al. Epidemiological features of HTLV-I carriers and incidence of ATL in an ATL-endemic island: a report of the community-based co-operative study in Tsushima, Japan. Int J Cancer. 1987;40:741-6 pubmed
    ..The recent annual incidence rates of ATL among 1,000 HTLV-I carriers older than 40 years living in Tsushima Island was estimated at 2.2 in males, 0.8 in females...
  51. Gardner M. Naturally occurring leukaemia viruses in wild mice: how good a model for humans?. Cancer Surv. 1987;6:55-71 pubmed
    ..These results illustrate the importance of studying natural history in the 'real world' and the limitations of laboratory artefacts such as those created by inbreeding of laboratory mice...
  52. Mylonas I, Brüning A, Kainer F, Friese K. HTLV infection and its implication in gynaecology and obstetrics. Arch Gynecol Obstet. 2010;282:493-501 pubmed publisher
    ..Worldwide, 20-30 million people are estimated to be infected with HTLV. HTLV-1 is endemic in Western Africa and Southern Japan, whereas HTLV-2 is considered to be spread among native American people...
  53. De Stasio G, Canavaggio M, Rizzi L, Lattanzio A, Lancieri M, D Erasmo F, et al. Screening for anti-human T-lymphotropic virus antibody in blood donors and polytransfused patients in Apulia (Italy). Vox Sang. 1990;59:167-71 pubmed
    ..Contrary to previous reports that claimed HTLV seroprevalences of between 0.3 and 8% in blood donors from Apulia (Italy), our data suggest that infection with this virus is principally restricted to intravenous drug abusers...