retroviridae infections

Summary

Summary: Virus diseases caused by the RETROVIRIDAE.

Top Publications

  1. Arnold R, Makarova N, Osunkoya A, Suppiah S, Scott T, Johnson N, et al. XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH. Urology. 2010;75:755-61 pubmed publisher
  2. Kunstman K, Bhattacharya T, Flaherty J, Phair J, Wolinsky S. Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV. AIDS. 2010;24:1784-5 pubmed
    ..Xenotropic murine leukemia virus-related virus was detected in none of the men on the basis of the absence of xenotropic murine leukemia virus-related virus DNA, suggesting that infection may be population-specific...
  3. Jeziorski E, Foulongne V, Ludwig C, Louhaem D, Chiocchia G, Segondy M, et al. No evidence for XMRV association in pediatric idiopathic diseases in France. Retrovirology. 2010;7:63 pubmed publisher
    ..None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies...
  4. Furuta R, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, et al. No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan. Retrovirology. 2011;8:20 pubmed publisher
    ..We also examined blood samples of viral antibody-positive patients with PC and all (both antibody-positive and antibody-negative) patients with CFS for XMRV DNA...
  5. Danielson B, Ayala G, Kimata J. Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions. J Infect Dis. 2010;202:1470-7 pubmed publisher
    ..We therefore investigated whether XMRV infection could be found in patients with prostate cancer from the southern United States, and we sought to verify the association with the R462Q...
  6. Stoye J, Silverman R, Boucher C, Le Grice S. The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop. Retrovirology. 2010;7:113 pubmed publisher
    ..The current status of XMRV research, concerns among the scientific community and suggestions for future actions are summarized in this meeting report...
  7. Wang X, Han Y, Dang Y, Fu W, Zhou T, Ptak R, et al. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. J Biol Chem. 2010;285:14346-55 pubmed publisher
    ..All of these results indicate that MOV10 has a broad antiretroviral activity that can target a wide range of retroviruses, and it could be actively involved in host defense against retroviral infection...
  8. Santiago M, Benitez R, Montano M, Hasenkrug K, Greene W. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010;185:1114-23 pubmed publisher
    ..These findings raise the possibility that enabling Apobec3 activity during acute infection with human pathogenic retroviruses, such as HIV-1, may similarly facilitate stronger virus-specific neutralizing Ab responses...
  9. Nair S, Zelinskyy G, Schimmer S, Gerlach N, Kassiotis G, Dittmer U. Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells. J Gen Virol. 2010;91:440-51 pubmed publisher
    ..The current study reveals that Th cells were critical for recovery from acute FV infection but were functionally impaired during the late phase of acute infection due to induced Tregs...

More Information

Publications61

  1. Langhammer S, Hübner J, Jarrett O, Kurth R, Denner J. Immunization with the transmembrane protein of a retrovirus, feline leukemia virus: absence of antigenemia following challenge. Antiviral Res. 2011;89:119-23 pubmed publisher
    ..For the first time we show that immunization with a retroviral TM protein prevented antigenemia. The level of neutralizing antibodies after the boost immunization correlated with the outcome of FeLV infection...
  2. Kozak C. The mouse "xenotropic" gammaretroviruses and their XPR1 receptor. Retrovirology. 2010;7:101 pubmed publisher
  3. Stocking C, Kozak C. Murine endogenous retroviruses. Cell Mol Life Sci. 2008;65:3383-98 pubmed publisher
    ..We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)...
  4. He X, Walker T, Maranga I, Oliver A, Hampson L, Hampson I. No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women. PLoS ONE. 2012;7:e47208 pubmed publisher
  5. Switzer W, Tang S, Ahuka Mundeke S, Shankar A, Hanson D, Zheng H, et al. Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo. Retrovirology. 2012;9:100 pubmed publisher
    ..Phylogenetic analysis was used to define the NHP species origin of SFV. Participants completed questionnaires to capture NHP exposure information...
  6. Jern P, Coffin J. Effects of retroviruses on host genome function. Annu Rev Genet. 2008;42:709-32 pubmed publisher
  7. Barnes E, Flanagan P, Brown A, Robinson N, Brown H, McClure M, et al. Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections. J Infect Dis. 2010;202:1482-5 pubmed publisher
    ..In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe...
  8. Satterfield B, Garcia R, Jia H, Tang S, Zheng H, Switzer W. Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses. Retrovirology. 2011;8:12 pubmed publisher
    ..Our findings, together with previous negative reports, do not suggest an association of XMRV or MuLV in the majority of CFS cases...
  9. Bleiholder A, Mühle M, Hechler T, Bevins S, Vandewoude S, Denner J, et al. Pattern of seroreactivity against feline foamy virus proteins in domestic cats from Germany. Vet Immunol Immunopathol. 2011;143:292-300 pubmed publisher
    ..Use of the FUV7- and F17/951 ElpSU antigens in ELISA resulted in the detection of Env-specific antibodies in both cat reference sera and sera from domestic cats in Germany, but failed to allow serotyping at the same time...
  10. Steffen I, Tyrrell D, Stein E, Montalvo L, Lee T, Zhou Y, et al. No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome. PLoS ONE. 2011;6:e27870 pubmed publisher
    ..Multiple techniques were employed, including nested and qRT-PCR, cell culture, and immunoblotting. We found no evidence of XMRV or MLV in humans and conclude that CFS is not associated with these gammaretroviruses...
  11. Groom H, Boucherit V, Makinson K, Randal E, Baptista S, Hagan S, et al. Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology. 2010;7:10 pubmed publisher
  12. Okeoma C, Petersen J, Ross S. Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection. J Virol. 2009;83:3029-38 pubmed publisher
    ..These data indicate that mA3 plays a role in the genetics of susceptibility and resistance to MMTV infection...
  13. Specke V, Plesker R, Wood J, Coulibaly C, Suling K, Patience C, et al. No in vivo infection of triple immunosuppressed non-human primates after inoculation with high titers of porcine endogenous retroviruses. Xenotransplantation. 2009;16:34-44 pubmed publisher
    ..Absence of PERV transmission has been shown in first experimental and clinical xenotransplantations; however, these trials suffered from the absence of long-term exposure (transplant survival) and profound immunosuppression...
  14. Singh S, Kaye S, Gore M, McClure M, Bunker C. The role of human endogenous retroviruses in melanoma. Br J Dermatol. 2009;161:1225-31 pubmed publisher
    ..In vitro and mouse models have provided fascinating insights into the potential mechanisms of HERVs in melanomagenesis. This review considers the evidence associating HERVs with melanoma...
  15. Simmons G, Young P, Hanger J, Jones K, Clarke D, McKee J, et al. Prevalence of koala retrovirus in geographically diverse populations in Australia. Aust Vet J. 2012;90:404-9 pubmed publisher
    ..To determine the prevalence of koala retrovirus (KoRV) in selected koala populations and to estimate proviral copy number in a subset of koalas...
  16. Rua R, Lepelley A, Gessain A, Schwartz O. Innate sensing of foamy viruses by human hematopoietic cells. J Virol. 2012;86:909-18 pubmed publisher
    ..Therefore, FV are potent inducers of type I IFN by pDCs and by PBMCs. This previously underestimated activation of the innate immune response may be involved in the control of viral replication in humans...
  17. Li J, Hakata Y, Takeda E, Liu Q, Iwatani Y, Kozak C, et al. Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency. PLoS Pathog. 2012;8:e1002478 pubmed publisher
    ..The widespread geographic distribution of this exon 5-including genetic variant suggests that in some Mus populations the cost of maintaining an effective but mutagenic enzyme may outweigh its antiviral function...
  18. Jones Engel L, May C, Engel G, Steinkraus K, Schillaci M, Fuentes A, et al. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia. Emerg Infect Dis. 2008;14:1200-8 pubmed publisher
    ..Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia...
  19. Choudhary A, Galvin T, Williams D, BEREN J, Bryant M, Khan A. Influence of naturally occurring simian foamy viruses (SFVs) on SIV disease progression in the rhesus macaque (Macaca mulatta) model. Viruses. 2013;5:1414-30 pubmed publisher
  20. Santiago M, Montano M, Benitez R, Messer R, Yonemoto W, Chesebro B, et al. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science. 2008;321:1343-6 pubmed publisher
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  21. Blasse A, Calvignac Spencer S, Merkel K, Goffe A, Boesch C, Mundry R, et al. Mother-offspring transmission and age-dependent accumulation of simian foamy virus in wild chimpanzees. J Virol. 2013;87:5193-204 pubmed publisher
    ..Our data give evidence for complex SFV dynamics in wild chimpanzees, even at a single community scale, and show that linking wild NHP social interactions and their microorganisms' dynamics is feasible...
  22. Rezaei S, Hearps A, Mills J, Pedersen J, Tachedjian G. No association between XMRV or related gammaretroviruses in Australian prostate cancer patients. Virol J. 2013;10:20 pubmed publisher
  23. Lo Y, Tian T, Nadeau P, Park J, Mergia A. The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus. J Virol. 2010;84:2832-42 pubmed publisher
    ..Furthermore, despite the presence of a nuclear localization signal sequence in Gag, we observed no foamy virus Gag importation into the nucleus in the absence of integrase...
  24. Afonso P, Ozden S, Cumont M, Seilhean D, Cartier L, Rezaie P, et al. Alteration of blood-brain barrier integrity by retroviral infection. PLoS Pathog. 2008;4:e1000205 pubmed publisher
  25. Morozov V, Leendertz F, Junglen S, Boesch C, Pauli G, Ellerbrok H. Frequent foamy virus infection in free-living chimpanzees of the Taï National Park (Côte d'Ivoire). J Gen Virol. 2009;90:500-6 pubmed publisher
    ..Frequent SFV infections in chimpanzees from this area significantly increase the potential risk of zoonotic transmission to rural populations through direct contact, hunting and consumption of bush meat...
  26. Qiu X, Swanson P, Luk K, Tu B, Villinger F, Das Gupta J, et al. Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies. Retrovirology. 2010;7:68 pubmed publisher
    ..Development of assays to detect XMRV-specific antibodies would greatly facilitate such studies. However, the nature and kinetics of the antibody response to XMRV infection have yet to be determined...
  27. Kearney M, Spindler J, Wiegand A, Shao W, Anderson E, Maldarelli F, et al. Multiple sources of contamination in samples from patients reported to have XMRV infection. PLoS ONE. 2012;7:e30889 pubmed publisher
  28. Paolucci S, Piralla A, Zanello C, Minoli L, Baldanti F. Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome. New Microbiol. 2012;35:341-4 pubmed
    ..These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested...
  29. Miyazawa T, Shojima T, Yoshikawa R, Ohata T. Isolation of koala retroviruses from koalas in Japan. J Vet Med Sci. 2011;73:65-70 pubmed
    ..By electron microscopy, we observed C-type retroviral particles in HEK 293T cells chronically infected with KoRV strain OJ-4. This is the first report on the isolation of KoRV from koalas in a Japanese zoo...
  30. Blomberg J, Blomberg F, Sjösten A, Sheikholvaezin A, Bölin Wiener A, Elfaitouri A, et al. No evidence for xenotropic murine leukemia-related virus infection in Sweden using internally controlled multiepitope suspension array serology. Clin Vaccine Immunol. 2012;19:1399-410 pubmed publisher
    ..The principle may be used for creation of variant tolerant peptide serologies. Thus, our system allows rational large-scale serological assays with built-in quality control...
  31. Korn K, Reil H, Ensser A, Knoll A. No evidence of XMRV infection in immunocompromised patients and HIV-positive individuals from Germany. Infection. 2012;40:181-4 pubmed publisher
    ..This study investigated whether or not XMRV is present in patients with altered immune function and individuals at increased risk of blood-borne viral infections in Germany...
  32. Shojima T, Hoshino S, Abe M, Yasuda J, Shogen H, Kobayashi T, et al. Construction and characterization of an infectious molecular clone of Koala retrovirus. J Virol. 2013;87:5081-8 pubmed publisher
    ..The infectious clone reported here will be useful for elucidating the mechanism of endogenization of the virus in koalas and screening for antiretroviral drugs for KoRV-infected koalas...
  33. Knox K, Carrigan D, Simmons G, Teque F, Zhou Y, Hackett J, et al. No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. Science. 2011;333:94-7 pubmed publisher
    ..Consistent with previous reports, we detected MLV sequences in commercial laboratory reagents. Our results indicate that previous evidence linking XMRV and MLVs to CFS is likely attributable to laboratory contamination...
  34. Takeda E, Tsuji Kawahara S, Sakamoto M, Langlois M, Neuberger M, Rada C, et al. Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo. J Virol. 2008;82:10998-1008 pubmed publisher
    ..These results indicate, for the first time, that mouse APOBEC3 is a physiologically functioning restriction factor to mouse gammaretroviruses...
  35. Fischer N, Hellwinkel O, Schulz C, Chun F, Huland H, Aepfelbacher M, et al. Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J Clin Virol. 2008;43:277-83 pubmed publisher
  36. Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Denner J, et al. Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. Retrovirology. 2009;6:92 pubmed publisher
    ..Here, we attempt to measure the prevalence of XMRV in prostate cancer cases in Germany and determine whether an analogous association with the R462Q polymorphism exists...
  37. Mitchell J, Murrell C, Auda G, Almond N, Rose N. Early immunopathology events in simian retrovirus, type 2 infections prior to the onset of disease. Virology. 2011;413:161-8 pubmed publisher
    ..Gross immunopathological changes in lymphoid tissues were similar between SRV infection and those observed for other simian retroviruses SIV and STLV, suggesting a common immunopathological response to infection with these agents...
  38. Zelinskyy G, Dietze K, Hüsecken Y, Schimmer S, Nair S, Werner T, et al. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood. 2009;114:3199-207 pubmed publisher
  39. Goldberg T, Sintasath D, Chapman C, Cameron K, Karesh W, Tang S, et al. Coinfection of Ugandan red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses. J Virol. 2009;83:11318-29 pubmed publisher
  40. Plochmann K, Horn A, Gschmack E, Armbruster N, Krieg J, Wiktorowicz T, et al. Heparan sulfate is an attachment factor for foamy virus entry. J Virol. 2012;86:10028-35 pubmed publisher
    ..Both PFV and FFV infection were inhibited by soluble heparin. Our results show that FVs bind to HS and that this interaction is a pivotal step for viral entry, suggesting that HS is a cellular attachment factor for FVs...
  41. Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N. Host range and cellular tropism of the human exogenous gammaretrovirus XMRV. Virology. 2010;399:23-30 pubmed publisher
    ..XMRV-LTR activity is significantly higher in the prostate cancer cell line LNCaP and in prostate stromal fibroblasts, compared to other cell types tested and could be one factor contributing to efficient viral spread in prostate tissue. ..
  42. Baraniuk J. Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer. Curr Allergy Asthma Rep. 2010;10:210-4 pubmed publisher
  43. Silverman R, Nguyen C, Weight C, Klein E. The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome. Nat Rev Urol. 2010;7:392-402 pubmed publisher
    ..Emerging science surrounding XMRV is contributing to our knowledge of retroviral infections while focusing intense interest on two major human diseases...
  44. Langlois M, Kemmerich K, Rada C, Neuberger M. The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3. J Virol. 2009;83:11550-9 pubmed publisher
  45. Santiago M, Smith D, Barrett B, Montano M, Benitez R, Pelanda R, et al. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011;85:189-99 pubmed publisher
    ..Overall, these findings argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3...
  46. Mouinga Ondémé A, Caron M, Nkoghé D, Telfer P, Marx P, Saïb A, et al. Cross-species transmission of simian foamy virus to humans in rural Gabon, Central Africa. J Virol. 2012;86:1255-60 pubmed publisher
    ..All but one were infected with ape SFV. We thus found novel SFV strains in NHPs in Gabon and high cross-species transmission of SFVs from gorilla bites. ..
  47. Bodem J, Schied T, Gabriel R, Rammling M, Rethwilm A. Foamy virus nuclear RNA export is distinct from that of other retroviruses. J Virol. 2011;85:2333-41 pubmed publisher
    ..Inhibition studies showed that both ANP32A and ANP32B, which are known to bridge HuR and CRM1, are essential for FV RNA export. By using this export pathway, FVs solve a central problem of viral replication...
  48. Balada E, Castro Marrero J, Felip L, Vilardell Tarres M, Ordi Ros J. Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus. J Clin Immunol. 2011;31:584-7 pubmed publisher
    ..Since chronic fatigue is commonly reported in patients with systemic lupus erythematosus (SLE) we aimed at testing the presence of this virus in these patients...
  49. Ploquin M, Eksmond U, Kassiotis G. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol. 2011;187:3321-30 pubmed publisher
    ..Our results suggest that B cell presentation of vaccine Ags could be manipulated to direct the appropriate CD4(+) T cell response...
  50. Arredondo M, Hackett J, de Bethencourt F, Trevino A, Escudero D, Collado A, et al. Prevalence of xenotropic murine leukemia virus-related virus infection in different risk populations in Spain. AIDS Res Hum Retroviruses. 2012;28:1089-94 pubmed publisher
    ..Likewise, XMRV was not recognized in patients with autoimmune diseases, chronic fatigue syndrome-fibromyalgia, prostate cancer, or healthy blood donors...
  51. Leendertz S, Junglen S, Hedemann C, Goffe A, Calvignac S, Boesch C, et al. High prevalence, coinfection rate, and genetic diversity of retroviruses in wild red colobus monkeys (Piliocolobus badius badius) in Tai National Park, Cote d'Ivoire. J Virol. 2010;84:7427-36 pubmed publisher
    ..The high prevalence of all three retroviral infections in P. b. badius represents a source of infection to chimpanzees and possibly to humans, who hunt them...
  52. Zhang A, Bogerd H, Villinger F, Das Gupta J, Dong B, Klein E, et al. In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins. Virology. 2011;421:28-33 pubmed publisher
    ..These studies show that some rhesus A3 isoforms are highly effective against XMRV in the blood of a non-human primate model of infection and in cultured human cells...