enterovirus infections

Summary

Summary: Diseases caused by ENTEROVIRUS.

Top Publications

  1. Mirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, Bailly J, et al. Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect. 2012;18:E110-8 pubmed publisher
    ..was set up to determine the clinical and epidemiological characteristics of HFMD/HA associated with enterovirus infections. A standardized report form was used to collect demographic and clinical data...
  2. Liu C, Chou A, Lien S, Lin H, Liu S, Chang J, et al. Identification and characterization of a cross-neutralization epitope of Enterovirus 71. Vaccine. 2011;29:4362-72 pubmed publisher
    ..Thus, VP2-28 could be used as the surrogate biomarker in the potency testing of candidate EV71 vaccines...
  3. Liu J, Dong W, Quan X, Ma C, Qin C, Zhang L. Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice. Arch Virol. 2012;157:539-43 pubmed publisher
    ..We therefore conclude that human PSGL-1 alone is not sufficient to modulate infection with the clinical EV71 strains of genotype C4 in mice...
  4. Chen H, Zhang Y, Yang E, Liu L, Che Y, Wang J, et al. The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates. Virology. 2012;432:417-26 pubmed publisher
  5. Zhu F, Liang Z, Li X, Ge H, Meng F, Mao Q, et al. Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet. 2013;381:1037-45 pubmed
    ..We aimed to assess the best possible dose and formulation, immunogenicity, and safety profile of this EV71 vaccine in healthy Chinese children...
  6. Bracho M, Gonzalez Candelas F, Valero A, Cordoba J, Salazar A. Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. Emerg Infect Dis. 2011;17:2223-31 pubmed publisher
  7. Rao C, Yergolkar P, Shankarappa K. Antigenic diversity of enteroviruses associated with nonpolio acute flaccid paralysis, India, 2007-2009. Emerg Infect Dis. 2012;18:1833-40 pubmed publisher
    ..0% of culture-positive and -negative cases, respectively, need to be identified. Association of human enterovirus with NP-AFP requires better assessment and understanding of health risks of NPEV infections after polio elimination...
  8. Lauinger I, Bible J, Halligan E, Aarons E, MacMahon E, Tong C. Lineages, sub-lineages and variants of enterovirus 68 in recent outbreaks. PLoS ONE. 2012;7:e36005 pubmed publisher
    ..Continuous global monitoring of the clinical and molecular epidemiology of EV68 is recommended...
  9. Linsuwanon P, Puenpa J, Suwannakarn K, Auksornkitti V, Vichiwattana P, Korkong S, et al. Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand, 2006-2011. PLoS ONE. 2012;7:e35190 pubmed publisher
    ..However, epidemiological data regarding this virus in particular on the Asian continent has so far been limited...

More Information

Publications62

  1. Dos Santos G, da Costa E, Tavares F, da Costa L, da Silva E. Genetic diversity of Echovirus 30 involved in aseptic meningitis cases in Brazil (1998-2008). J Med Virol. 2011;83:2164-71 pubmed publisher
    ..The present results complement existing data on the molecular characterization and genetic variability of E30 and may contribute to the understanding of the epidemiology of aseptic meningitis in the region...
  2. Baek K, Yeo S, Lee B, Park K, Song J, Yu J, et al. Epidemics of enterovirus infection in Chungnam Korea, 2008 and 2009. Virol J. 2011;8:297 pubmed publisher
    ..Comparison of the VP1 amino acid sequences of the Korean coxsackievirus B5 isolates with reference strains revealed amino acid sequence substitutions at nine amino acid sequences (532, 562, 570, 571, 576-578, 582, 583, and 585)...
  3. Harvala H, McIntyre C, Imai N, Clasper L, Djoko C, LeBreton M, et al. High seroprevalence of enterovirus infections in apes and old world monkeys. Emerg Infect Dis. 2012;18:283-6 pubmed publisher
    ..Detection of species A, B, and D EVs infecting wild chimpanzees demonstrates their potential widespread circulation in primates. ..
  4. Meijer A, van der Sanden S, Snijders B, Jaramillo Gutierrez G, Bont L, van der Ent C, et al. Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010. Virology. 2012;423:49-57 pubmed publisher
    ..Clinical laboratories should consider enterovirus diagnostics in the differential diagnosis of patients presenting with respiratory symptoms...
  5. Zhu F, Meng F, Li J, Li X, Mao Q, Tao H, et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2013;381:2024-32 pubmed publisher
    ..We assessed the efficacy, safety, immunogenicity, antibody persistence, and immunological correlates of an inactivated alum-adjuvant EV71 vaccine...
  6. Tan C, Ninove L, Gaudart J, Nougairede A, Zandotti C, Thirion Perrier L, et al. A retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of Marseille, France (1985-2005). PLoS ONE. 2011;6:e18022 pubmed publisher
    ..Phylogenetic analysis in the VP1, 2C and 3D regions also provided evidence for recombination events amongst clinical isolates. In particular, it identified isolates with dissimilar VP1 but almost identical nonstructural regions...
  7. Han J, Cao R, Deng Y, Tian X, Jiang T, Qin E, et al. Antibody dependent enhancement infection of enterovirus 71 in vitro and in vivo. Virol J. 2011;8:106 pubmed publisher
    ..Antibody dependent enhancement (ADE) infection has been reported in various viruses and has been shown to contribute to disease severity...
  8. Apostol L, Suzuki A, Bautista A, Galang H, Paladin F, Fuji N, et al. Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines. J Med Virol. 2012;84:624-31 pubmed publisher
    ..Despite some limitations in this study, plural NPEVs with multiple patterns of circulation in the Philippines for 17 years were identified...
  9. Chen P, Song Z, Qi Y, Feng X, Xu N, Sun Y, et al. Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2. J Biol Chem. 2012;287:6406-20 pubmed publisher
    ..6). These studies elucidated the viral capsid and receptor determinants of enterovirus 71 infection and revealed a possible target for antiviral interventions...
  10. Ch ng W, Saw W, Yusoff K, Shafee N. Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice. Acta Virol. 2011;55:227-33 pubmed
    ..Taken together, Nt-VP1t protein is a potent immunogen in adult mice and our findings provide the data needed for testing of its protective efficacy in mouse models of EV71 infections...
  11. Meng F, Li J, Li X, Chu K, Zhang Y, Ji H, et al. Tolerability and immunogenicity of an inactivated enterovirus 71 vaccine in Chinese healthy adults and children: an open label, phase 1 clinical trial. Hum Vaccin Immunother. 2012;8:668-74 pubmed publisher
    ..No obvious dose-response relationship for immunogenicity was found...
  12. Tran C, Nguyen H, Phan H, Tran N, Wills B, Farrar J, et al. The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam. PLoS ONE. 2011;6:e21116 pubmed publisher
    ..Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries...
  13. Lee M, Tseng F, Wang J, Chi C, Chong P, Su I. Challenges to licensure of enterovirus 71 vaccines. PLoS Negl Trop Dis. 2012;6:e1737 pubmed publisher
    ..Prospective cohort studies are warranted to clarify clinical and epidemiological significances of the antigenic and genetic variations between different EV71 genogroups, which is critical for vaccine design...
  14. Jia C, Chen X, Li X, Li M, Miao C, Sun B, et al. The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors. J Trace Elem Med Biol. 2011;25:154-9 pubmed publisher
    ..These studies suggested that DHEA prevents oxidative stress and might be useful in treating Se and VE deficiency-related KD. These effects were based on its antioxidant effects and ECM deposition inhibition in left ventricles...
  15. Wang J, Zhang Y, Hong M, Li X, Zhu S, Yan D, et al. Isolation and characterization of a Chinese strain of human enterovirus 74 from a healthy child in the Tibet Autonomous Region of China. Arch Virol. 2012;157:1593-8 pubmed publisher
    ..Sequence analysis revealed high variability among HEV74 strains and indicated frequent recombination within HEV-B...
  16. Bessaud M, Pillet S, Ibrahim W, Joffret M, Pozzetto B, Delpeyroux F, et al. Molecular characterization of human enteroviruses in the Central African Republic: uncovering wide diversity and identification of a new human enterovirus A71 genogroup. J Clin Microbiol. 2012;50:1650-8 pubmed publisher
  17. Chi C, Khanh T, Thoa L, Tseng F, Wang S, Thinh L, et al. Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial. Crit Care Med. 2013;41:1754-60 pubmed publisher
    ..This prospective, randomized control trial was designed to provide more definitive evidence of the ability of milrinone to reduce the 1-week mortality of stage 3B enterovirus 71 infections...
  18. Wang R, Kuo R, Ma W, Huang H, Yu J, Yen S, et al. Heat shock protein-90-beta facilitates enterovirus 71 viral particles assembly. Virology. 2013;443:236-47 pubmed publisher
  19. Zhang G, Zhou F, Gu B, Ding C, Feng D, Xie F, et al. In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection. Arch Virol. 2012;157:669-79 pubmed publisher
    ..In all, the results demonstrated that infected cells and infected mice can be used to evaluate antiviral activity of ribavirin and pleconaril against EV71 infection in vitro and in vivo...
  20. Li J, Chen F, Liu T, Wang L. MRI findings of neurological complications in hand-foot-mouth disease by enterovirus 71 infection. Int J Neurosci. 2012;122:338-44 pubmed publisher
    ..To explore the imaging characterization of neurological complications associated with the enterovirus 71 (EV71) epidemics...
  21. Huang S, Wang Y, Yu C, Su I, Wang J. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology. 2012;422:132-43 pubmed publisher
    ..In sum, VP2(149M) and VP1(145E) mutations cooperatively promote viral binding and RNA accumulation of EV71, contributing to viral infectivity in vitro and mouse lethality in vivo...
  22. Tryfonos C, Richter J, Koptides D, Yiangou M, Christodoulou C. Molecular typing and epidemiology of enteroviruses in Cyprus, 2003-2007. J Med Microbiol. 2011;60:1433-40 pubmed publisher
    ..Serotype distribution corresponded essentially with observations reported from other European countries in the same period. The present report demonstrates the epidemiology of enteroviruses in Cyprus from 2003 to 2007...
  23. Hsu C, Lu C, Shao P, Lee P, Kao C, Chung M, et al. Epidemiologic and clinical features of non-polio enteroviral infections in northern Taiwan in 2008. J Microbiol Immunol Infect. 2011;44:265-73 pubmed publisher
  24. Dong C, Liu L, Zhao H, Wang J, Liao Y, Zhang X, et al. Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys. Vaccine. 2011;29:6269-75 pubmed publisher
  25. Mao Q, Dong C, Li X, Gao Q, Guo Z, Yao X, et al. Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice. PLoS ONE. 2012;7:e46043 pubmed publisher
    ..Thus, properly comparing newly developed vaccines has become a priority, especially in China...
  26. Ikeda T, Mizuta K, Abiko C, Aoki Y, Itagaki T, Katsushima F, et al. Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010. Microbiol Immunol. 2012;56:139-43 pubmed publisher
    ..Phylogenetic analysis indicated that plural genetically distinct clusters co-circulated. These results suggest that that difficulty in EV68 isolation leads to an underestimation of the prevalence of EV68 infections...
  27. Ch ng W, Stanbridge E, Ong K, Wong K, Yusoff K, Shafee N. Partial protection against enterovirus 71 (EV71) infection in a mouse model immunized with recombinant Newcastle disease virus capsids displaying the EV71 VP1 fragment. J Med Virol. 2011;83:1783-91 pubmed publisher
  28. Wang S, Ho T, Lin H, Lei H, Wang J, Liu C. Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity. Eur J Clin Microbiol Infect Dis. 2012;31:1219-24 pubmed publisher
    ..This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71...
  29. Simonen Tikka M, Pflueger M, Klemola P, Savolainen Kopra C, Smura T, Hummel S, et al. Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study. Diabetologia. 2011;54:2995-3002 pubmed publisher
  30. McMinn P. Recent advances in the molecular epidemiology and control of human enterovirus 71 infection. Curr Opin Virol. 2012;2:199-205 pubmed publisher
    ..Furthermore, ongoing investigations into the molecular basis of HEV71 infection and virulence have pointed the way towards novel approaches to live attenuated vaccine development...
  31. Chiang P, Huang M, Luo S, Lin T, Tsao K, Lee M. Comparing molecular methods for early detection and serotyping of enteroviruses in throat swabs of pediatric patients. PLoS ONE. 2012;7:e48269 pubmed publisher
    ..In this study, we compare virus isolation and two molecular tests for detection and serotyping of enteroviruses in clinical samples...
  32. Volle R, Nourrisson C, Mirand A, Regagnon C, Chambon M, Henquell C, et al. Quantitative real-time RT-PCR assay for research studies on enterovirus infections in the central nervous system. J Virol Methods. 2012;185:142-8 pubmed publisher
    ..The sensitivity and reproducibility of the real time RT-qPCR assay used in combination with the internal control to monitor the overall specimen process make it a valuable tool with applied research into enterovirus infections.
  33. Chou A, Liu C, Chang J, Lien S, Guo M, Tasi H, et al. Immunological evaluation and comparison of different EV71 vaccine candidates. Clin Dev Immunol. 2012;2012:831282 pubmed
    ..Therefore, the best formulation for producing cost-effective HFMD vaccine is a combination of formalin-inactivated EV71 and CAV16 virions...
  34. Kreuter J, Barnes A, McCarthy J, Schwartzman J, Oberste M, Rhodes C, et al. A fatal central nervous system enterovirus 68 infection. Arch Pathol Lab Med. 2011;135:793-6 pubmed publisher
    ..We therefore report a case of fatal meningomyeloencephalitis caused by enterovirus 68 in a 5-year-old boy, which required neuropathology, microbiology, and molecular techniques to diagnose...
  35. Zhao K, Han X, Wang G, Hu W, Zhang W, Yu X. Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China. Emerg Infect Dis. 2011;17:1537-40 pubmed publisher
    ..Complex recombinant forms of CA16-related viruses involving multiple human enteroviruses, subgroup A (CA4, CA16, and enterovirus 71), are prevalent among patients with hand, foot, and mouth disease...
  36. Ku Z, Ye X, Huang X, Cai Y, Liu Q, Li Y, et al. Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps. PLoS ONE. 2013;8:e57601 pubmed publisher
    ..However, how neutralizing antibodies inhibit infection in vitro remains unclear...
  37. Bek E, Hussain K, Phuektes P, Kok C, Gao Q, Cai F, et al. Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection. Vaccine. 2011;29:4829-38 pubmed publisher
    ..Immunised mice developed a neutralising antibody response to both the immunising C4 strain and to the mouse-adapted strain. Mice born to immunised dams showed significantly less myositis and reduced viral loads in tissues...
  38. Hung H, Wang H, Shih S, Teng I, Tseng C, Hsu J. Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir. J Infect Dis. 2011;203:1784-90 pubmed publisher
    ..Although interferon (IFN)-? has been used in the treatment of several viral infections, we found that IFN-? alone was ineffective in restricting EV71 replication in Vero cells...
  39. Lee M, Chan P, Ho I, Lai W. Enterovirus infection among patients admitted to hospital in Hong Kong in 2010: epidemiology, clinical characteristics, and importance of molecular diagnosis. J Med Virol. 2013;85:1811-7 pubmed publisher
    ..Diagnosis of EV infection among hospitalized patients may not be straightforward. EV RT-PCR significantly improved laboratory diagnosis and delineation of epidemiology of EV infection compared to conventional methods...
  40. Ni H, Yi B, Yin J, Fang T, He T, Du Y, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2008-2011. J Clin Virol. 2012;54:342-8 pubmed publisher
    ..Outbreaks of hand, foot, and mouth disease (HFMD) in central China have caused public health concerns since 2007. It is of particular public health significance to update epidemiology of HFMD in port cities...
  41. Lim X, Jia Q, Khong W, Yan B, Premanand B, Alonso S, et al. Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of enterovirus 71 infection. PLoS ONE. 2012;7:e29751 pubmed publisher
    ..Enterovirus 71 (EV71) is the main causative agent of Hand, Foot and Mouth disease (HFMD) and is associated with severe neurologic complications and mortalities. At present, there is no vaccine or therapeutic available for treatment...
  42. Tokarz R, Firth C, Madhi S, Howie S, Wu W, Sall A, et al. Worldwide emergence of multiple clades of enterovirus 68. J Gen Virol. 2012;93:1952-8 pubmed publisher
    ..All clades appear to be currently circulating and contributing to respiratory disease...
  43. Debiaggi M, Ceresola E, Sampaolo M, Alessandrino E, Brerra R, Piazza A, et al. Epidemiological, molecular and clinical features of enterovirus 109 infection in children and in adult stem cell transplant recipients. Virol J. 2012;9:183 pubmed publisher
  44. Cao R, Han J, Jiang T, Tian X, Yu M, Deng Y, et al. In vitro and in vivo characterization of a new enterovirus type 71-specific human intravenous immunoglobulin manufactured from selected plasma donors. J Clin Virol. 2011;51:246-9 pubmed publisher
    ..Antibody-based therapy represents a promising alternative strategy for lethal EV71 infection. Our previous data has shown that anti-EV71 neutralization antibodies were present in a significant proportion of blood donors in China...
  45. Lin Y, Yu C, Hu Y, Tsai T, Kuo Y, Chi W, et al. Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles. Vaccine. 2012;30:1305-12 pubmed publisher
    ..Hence, VLP-based EV71 vaccine is a potential vaccine against EV71 infection...
  46. Cohen Bacrie S, Ninove L, Nougairede A, Charrel R, Richet H, Minodier P, et al. Revolutionizing clinical microbiology laboratory organization in hospitals with in situ point-of-care. PLoS ONE. 2011;6:e22403 pubmed publisher
    ..Clinical microbiology may direct decisions regarding hospitalization, isolation and anti-infective therapy, but it is not effective at the time of early care. Point-of-care (POC) tests have been developed for this purpose...
  47. Yamayoshi S, Iizuka S, Yamashita T, Minagawa H, Mizuta K, Okamoto M, et al. Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71. J Virol. 2012;86:5686-96 pubmed publisher
    ..HEV-A viruses can be divided into at least two groups depending on the use of SCARB2, and the receptor usage plays an important role in developing the specific diseases for each group...
  48. Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, et al. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol. 2012;19:424-9 pubmed publisher
  49. Yeh M, Wang S, Yu C, Lin K, Lei H, Su I, et al. A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice. PLoS ONE. 2011;6:e27082 pubmed publisher
    ..Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored...
  50. de Crom S, van Furth M, Peeters M, Rossen J, Obihara C. Characteristics of pediatric patients with enterovirus meningitis and no cerebral fluid pleocytosis. Eur J Pediatr. 2012;171:795-800 pubmed publisher
    ..60; 95% CI 2.24-41.15; p?=?0.002), had lower white blood cell counts (OR 0.73; 95% CI 0.61-0.89; p?=?0.001), and had higher C-reactive protein (OR 1.13; 95% CI 1.03-1.23; p?=?0.006) than those with pleocytosis...
  51. Lu J, Yi L, Zhao J, Yu J, Chen Y, Lin M, et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J Virol. 2012;86:3767-76 pubmed publisher
    ..Taken together, our study for the first time uncovers a mechanism used by EV71 to antagonize type I IFN signaling and provides new targets for future antiviral strategies...
  52. van der Sanden S, van Eek J, Martin D, van der Avoort H, Vennema H, Koopmans M. Detection of recombination breakpoints in the genomes of human enterovirus 71 strains isolated in the Netherlands in epidemic and non-epidemic years, 1963-2010. Infect Genet Evol. 2011;11:886-94 pubmed publisher
    ..The difference observed in the 5'UTR of EV71 strains isolated in endemic versus epidemic years suggests that changes in the 5'UTR cause evolution of strains capable of causing outbreaks...
  53. McWilliam Leitch E, Cabrerizo M, Cardosa J, Harvala H, Ivanova O, Koike S, et al. The association of recombination events in the founding and emergence of subgenogroup evolutionary lineages of human enterovirus 71. J Virol. 2012;86:2676-85 pubmed publisher
    ..The possibility that recombination contributed to their subsequent spread through improved fitness requires further biological and immunological characterization...