coronavirus infections

Summary

Summary: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).

Top Publications

  1. Tang X, Agnihothram S, Jiao Y, Stanhope J, Graham R, Peterson E, et al. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc Natl Acad Sci U S A. 2014;111:E2018-26 pubmed publisher
    ..Moreover, in the absence of a licensed vaccine or antiviral for MERS, this panel of nAbs offers the possibility of developing human mAb-based immunotherapy, especially for health-care workers. ..
  2. Omrani A, Matin M, Haddad Q, Al Nakhli D, Memish Z, Albarrak A. A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis. 2013;17:e668-72 pubmed publisher
    ..Ninety confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) have been reported to the World Health Organization. We report the details of a second family cluster of MERS-CoV infections from Riyadh, Saudi Arabia...
  3. Cabeça T, Granato C, Bellei N. Epidemiological and clinical features of human coronavirus infections among different subsets of patients. Influenza Other Respir Viruses. 2013;7:1040-7 pubmed publisher
    ..We conducted a comprehensive 9-year study on HCoVs by analyzing 1137 respiratory samples from four subsets of patients (asymptomatic, general community, with comorbidities, and hospitalized) in São Paulo, Brazil...
  4. Albarrak A, Stephens G, Hewson R, Memish Z. Recovery from severe novel coronavirus infection. Saudi Med J. 2012;33:1265-9 pubmed
    ..Contact investigations are in progress. Future work will focus not only on the origin of the virus and mechanisms of transmission, but also the host factors that influence pathogenesis and prognosis...
  5. Azhar E, El Kafrawy S, Farraj S, Hassan A, Al Saeed M, Hashem A, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014;370:2499-505 pubmed publisher
    ..These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel. ..
  6. Zhao J, Li K, Wohlford Lenane C, Agnihothram S, Fett C, Zhao J, et al. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A. 2014;111:4970-5 pubmed publisher
    ..Our results demonstrate that this system will be useful for MERS-CoV studies and for the rapid development of relevant animal models for emerging respiratory viral infections. ..
  7. Falzarano D, de Wit E, Rasmussen A, Feldmann F, Okumura A, Scott D, et al. Treatment with interferon-?2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med. 2013;19:1313-7 pubmed publisher
    ..As these two drugs are already used in combination in the clinic for other infections, IFN-?2b and ribavirin should be considered for the management of MERS-CoV cases. ..
  8. Hijawi B, Abdallat M, Sayaydeh A, Alqasrawi S, Haddadin A, Jaarour N, et al. Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation. East Mediterr Health J. 2013;19 Suppl 1:S12-8 pubmed
    ..A total of 2 laboratory-confirmed and 11 probable cases were identified from this outbreak of whom 10 were HCWs and 2 were family members of cases...
  9. Annan A, Baldwin H, Corman V, Klose S, Owusu M, Nkrumah E, et al. Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe. Emerg Infect Dis. 2013;19:456-9 pubmed publisher
    ..Viruses related to the novel human betacoronavirus EMC/2012 were detected in 46 (24.9%) of 185 Nycteris bats and 40 (14.7%) of 272 Pipistrellus bats. Their genetic relatedness indicated EMC/2012 originated from bats...

More Information

Publications62

  1. Chan R, Chan M, Agnihothram S, Chan L, Kuok D, Fong J, et al. Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures. J Virol. 2013;87:6604-14 pubmed publisher
    ..Treatment of human lung tissue ex vivo organ cultures with type I IFNs (alpha and beta IFNs) at 1 h postinfection reduced the replication of HCoV-EMC, suggesting a potential therapeutic use of IFNs for treatment of human infection...
  2. Jevšnik M, Ursic T, Zigon N, Lusa L, Krivec U, Petrovec M. Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease. BMC Infect Dis. 2012;12:365 pubmed publisher
    ..The aim of this study was to estimate the prevalence of human coronavirus infections in a series of children hospitalized with symptoms of acute respiratory tract disease in a one-year period ..
  3. Liu X, Ma H, Xu Q, Sun N, Han Z, Sun C, et al. Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3' untranslated region. Vet Microbiol. 2013;162:429-36 pubmed publisher
    ..This recombination event took place at the 3' end of the N gene and the 3' untranslated region may account for differences in replication efficiency in tissues of chickens inoculated by the two viruses...
  4. Al Ahdal M, Al Qahtani A, Rubino S. Coronavirus respiratory illness in Saudi Arabia. J Infect Dev Ctries. 2012;6:692-4 pubmed publisher
    ..The emergence of these novel isolates that resulted in fatal human infection ascertains that health authorities all over the world must be vigilant for the possibility of new global pandemics due to novel viral infection...
  5. Pan Y, Tian X, Li W, Zhou Q, Wang D, Bi Y, et al. Isolation and characterization of a variant porcine epidemic diarrhea virus in China. Virol J. 2012;9:195 pubmed publisher
    ..Further studies will be required to determine the immunogenicity and pathogenicity of this new variant...
  6. Smith E, Denison M. Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Curr Opin Virol. 2012;2:519-24 pubmed publisher
    ..Recent studies support the hypothesis that coronavirus replication fidelity may result from a multi-protein complex, suggesting multiple pathways to disrupt or alter virus fidelity and diversity, and attenuate pathogenesis...
  7. Chen X, Yang J, Yu F, Ge J, Lin T, Song T. Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) samples from field cases in Fujian, China. Virus Genes. 2012;45:499-507 pubmed publisher
    ..The study is useful to better understand the prevalence of PEDV and its prevention and control in Fujian...
  8. Du L, Zhao G, Kou Z, Ma C, Sun S, Poon V, et al. Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development. J Virol. 2013;87:9939-42 pubmed publisher
  9. Drosten C, Seilmaier M, Corman V, Hartmann W, Scheible G, Sack S, et al. Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis. 2013;13:745-51 pubmed publisher
    ..We provide a full description of a fatal case of MERS-CoV infection and associated phylogenetic analyses...
  10. Guery B, Poissy J, El Mansouf L, Séjourné C, Ettahar N, Lemaire X, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet. 2013;381:2265-72 pubmed publisher
    ..We report detailed clinical and virological data for two related cases of MERS-CoV disease, after nosocomial transmission of the virus from one patient to another in a French hospital...
  11. Nowotny N, Kolodziejek J. Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013. Euro Surveill. 2014;19:20781 pubmed
    ..High viral loads in nasal and conjunctival swabs suggest possible transmission by the respiratory route...
  12. Memish Z, Zumla A, Al Hakeem R, Al Rabeeah A, Stephens G. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med. 2013;368:2487-94 pubmed publisher
    ..Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients. ..
  13. Cotten M, Lam T, Watson S, Palser A, Petrova V, Grant P, et al. Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis. 2013;19:736-42B pubmed publisher
  14. Chan J, Li K, To K, Cheng V, Chen H, Yuen K. Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?. J Infect. 2012;65:477-89 pubmed publisher
    ..Despite the apparently low transmissibility of the virus at this stage, research preparedness against another SARS-like pandemic is an important precautionary strategy...
  15. Cotten M, Watson S, Kellam P, Al Rabeeah A, Makhdoom H, Assiri A, et al. Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. Lancet. 2013;382:1993-2002 pubmed publisher
    ..Saudi Arabian Ministry of Health, Wellcome Trust, European Community, and National Institute of Health Research University College London Hospitals Biomedical Research Centre. ..
  16. Tirotta E, Duncker P, Oak J, Klaus S, Tsukamoto M, Gov L, et al. Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis. J Neuroimmunol. 2013;254:110-6 pubmed publisher
    ..These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection...
  17. Assiri A, Al Tawfiq J, Al Rabeeah A, Al Rabiah F, Al Hajjar S, Al Barrak A, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13:752-61 pubmed publisher
    ..Clinical data on MERS-CoV infections are scarce. We report epidemiological, demographic, clinical, and laboratory characteristics of 47 cases of MERS-CoV infections, identify knowledge gaps, and define research priorities...
  18. Stevenson G, Hoang H, Schwartz K, Burrough E, Sun D, Madson D, et al. Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences. J Vet Diagn Invest. 2013;25:649-54 pubmed publisher
    ..0%) to some of the 2011-2012 Chinese strains. The nearly simultaneous outbreaks of disease, and high degree of homology (99.6-100%) between the PEDV strains from the 4 unrelated farms, suggests a common source of virus. ..
  19. Kindler E, Jónsdóttir H, Muth D, Hamming O, Hartmann R, Rodriguez R, et al. Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential. MBio. 2013;4:e00611-12 pubmed publisher
    ..Importantly, type I and type III interferon treatment can efficiently reduce HCoV-EMC replication in the human airway epithelium, providing a possible avenue for treatment of emerging virus infections...
  20. Perera R, Wang P, Gomaa M, el Shesheny R, Kandeil A, Bagato O, et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013;18:pii=20574 pubmed
  21. Pebody R, Chand M, Thomas H, Green H, Boddington N, Carvalho C, et al. The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012. Euro Surveill. 2012;17:20292 pubmed
    ..Ten days after last exposure, none of 64 close contacts had developed severe disease, with 13 of 64 reporting mild respiratory symptoms. The novel coronavirus was not detected in 10 of 10 symptomatic contacts tested...
  22. Chan J, Chan K, Kao R, To K, Zheng B, Li C, et al. Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. J Infect. 2013;67:606-16 pubmed publisher
    ..Person-to-person transmission is evident in outbreaks involving household and hospital contacts. Effective antivirals are urgently needed...
  23. Huang Y, Dickerman A, Piñeyro P, Li L, Fang L, Kiehne R, et al. Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States. MBio. 2013;4:e00737-13 pubmed publisher
    ..The data from this study have important implications for understanding the ongoing PEDV outbreaks in the United States and will guide future efforts to develop effective preventive and control measures against PEDV...
  24. Chen Q, Li G, Stasko J, Thomas J, Stensland W, Pillatzki A, et al. Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States. J Clin Microbiol. 2014;52:234-43 pubmed publisher
    ..Phylogenetic analyses using different genes of PEDV suggested that the full-length spike gene or the S1 portion is appropriate for sequencing to study the genetic relatedness of these viruses. ..
  25. Raj V, Mou H, Smits S, Dekkers D, Muller M, Dijkman R, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature. 2013;495:251-4 pubmed publisher
    ..In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies...
  26. Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen J, et al. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol. 2012;86:12816-25 pubmed publisher
  27. Maier H, Hawes P, Cottam E, Mantell J, Verkade P, Monaghan P, et al. Infectious bronchitis virus generates spherules from zippered endoplasmic reticulum membranes. MBio. 2013;4:e00801-13 pubmed publisher
  28. Lu L, Liu Q, Du L, Jiang S. Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread. Microbes Infect. 2013;15:625-9 pubmed publisher
    ..This review discusses the challenges in identifying the source of this fatal virus and developing effective and safe anti-MERS-CoV vaccines and therapeutics in order to control its spread and to combat any future pandemic. ..
  29. Niemeyer D, Zillinger T, Muth D, Zielecki F, Horvath G, Suliman T, et al. Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist. J Virol. 2013;87:12489-95 pubmed publisher
    ..Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA. ..
  30. Hemida M, Perera R, Wang P, Alhammadi M, Siu L, Li M, et al. Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill. 2013;18:20659 pubmed
    ..Some nevertheless displayed specific serologic reaction profiles to MERS-CoV...
  31. Assiri A, Mcgeer A, Perl T, Price C, Al Rabeeah A, Cummings D, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369:407-16 pubmed publisher
    ..Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response. ..
  32. Kuo S, Kao H, Hou M, Wang C, Lin S, Su H. Evolution of infectious bronchitis virus in Taiwan: positively selected sites in the nucleocapsid protein and their effects on RNA-binding activity. Vet Microbiol. 2013;162:408-18 pubmed publisher
  33. Bermingham A, Chand M, Brown C, Aarons E, Tong C, Langrish C, et al. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill. 2012;17:20290 pubmed
    ..We describe here the clinical and virological features of a novel coronavirus infection causing severe respiratory illness in a patient transferred to London, United Kingdom, from the Gulf region of the Middle East...
  34. Li W, Li H, Liu Y, Pan Y, Deng F, Song Y, et al. New variants of porcine epidemic diarrhea virus, China, 2011. Emerg Infect Dis. 2012;18:1350-3 pubmed publisher
    ..Three new PEDV variants were identified...
  35. Dominguez S, Robinson C, Holmes K. Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado. J Med Virol. 2009;81:1597-604 pubmed publisher
    ..Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases...
  36. Jang J, Sung H, Song C, Kwon H. Sequence analysis of the S1 glycoprotein gene of infectious bronchitis viruses: identification of a novel phylogenetic group in Korea. J Vet Sci. 2007;8:401-7 pubmed
    ..Specifically, the new Korean IBV isolates K10217-03, K3-3 and K1255-03 represented a separate group. These findings suggest that the Korean IBVs appear to be continuously evolving...
  37. Chen J, Sun D, Wang C, Shi H, Cui X, Liu S, et al. Molecular characterization and phylogenetic analysis of membrane protein genes of porcine epidemic diarrhea virus isolates in China. Virus Genes. 2008;36:355-64 pubmed publisher
    ..These results demonstrated that there was a new genotype of PEDV prevailing in China...
  38. Dijkman R, Jebbink M, El Idrissi N, Pyrc K, Muller M, Kuijpers T, et al. Human coronavirus NL63 and 229E seroconversion in children. J Clin Microbiol. 2008;46:2368-73 pubmed publisher
    ..5 to 3.5 years were HCoV-NL63 and HCoV-229E seropositive, respectively. We conclude that on average, HCoV-NL63 and HCoV-229E seroconversion occurs before children reach the age of 3.5 years...
  39. Quiroga M, Cappuccio J, Piñeyro P, Basso W, Moré G, Kienast M, et al. Hemagglutinating encephalomyelitis coronavirus infection in pigs, Argentina. Emerg Infect Dis. 2008;14:484-6 pubmed publisher
    ..Diagnosis was made by epidemiologic factors, pathologic features, immunohistochemistry, reverse transcription-PCR, and genomic sequencing. This study documents PHE-CoV infection in South America...
  40. Escutenaire S, Isaksson M, Renström L, Klingeborn B, Buonavoglia C, Berg M, et al. Characterization of divergent and atypical canine coronaviruses from Sweden. Arch Virol. 2007;152:1507-14 pubmed
    ..A recombinant origin of the fifth virus identified in the Stockholm region is suggested. In addition, the five viruses originating from the same geographical area displayed atypical 5' S gene sequences...
  41. Cervantes Barragan L, Kalinke U, Zust R, König M, Reizis B, Lopez Macias C, et al. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol. 2009;182:1099-106 pubmed
  42. De Albuquerque N, Baig E, Ma X, Zhang J, He W, Rowe A, et al. Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol. 2006;80:10382-94 pubmed
    ..This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies...
  43. Jung K, Renukaradhya G, Alekseev K, Fang Y, Tang Y, Saif L. Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections. J Gen Virol. 2009;90:2713-23 pubmed publisher
    ..This study provides new insights into host-pathogen interactions related to co-infection by CoVs and other respiratory viruses...
  44. Bender S, Weiss S. Pathogenesis of murine coronavirus in the central nervous system. J Neuroimmune Pharmacol. 2010;5:336-54 pubmed publisher
  45. Bhardwaj K, Liu P, Leibowitz J, Kao C. The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein. J Virol. 2012;86:4294-304 pubmed publisher
    ..This study reveals that pRb and its interaction with Nsp15 can affect coronavirus infection and adds coronaviruses to a small but growing family of RNA viruses that encode a protein to interact with pRb...
  46. Gharaibeh S. Infectious bronchitis virus serotypes in poultry flocks in Jordan. Prev Vet Med. 2007;78:317-24 pubmed
  47. Bing G, Liu X, Pu J, Liu Q, Wu Q, Liu J. Different genotypes of nephropathogenic infectious bronchitis viruses co-circulating in chicken population in China. Virus Genes. 2007;35:333-7 pubmed
    ..Phylogenetic analysis suggested that they belonged to different lineages. These findings indicated that different genotypes of nephropathogenic IB viruses were co-circulating in the chicken population in China...
  48. Shi X, Zhao Y, Gao H, Jing Z, Wang M, Cui H, et al. Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-? gene for immune protection against heterologous strains. Vaccine. 2011;29:1576-82 pubmed publisher
    ..05). These results indicate that the rFPV-IFN?S1 protected chickens against challenge with homotypic IBV strain LX4 and heterotypic strains LHLJ04XI and LHB...
  49. Martelli P, Lavazza A, Nigrelli A, Merialdi G, Alborali L, Pensaert M. Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy. Vet Rec. 2008;162:307-10 pubmed
    ..In growers and fatteners the morbidity ranged from 20 to 80 per cent, but there was either no mortality or it was very low. Depending on the size of the herd and the type of operation, the clinical disease lasted for weeks or months...
  50. Severance E, Bossis I, Dickerson F, Stallings C, Origoni A, Sullens A, et al. Development of a nucleocapsid-based human coronavirus immunoassay and estimates of individuals exposed to coronavirus in a U.S. metropolitan population. Clin Vaccine Immunol. 2008;15:1805-10 pubmed publisher
    ..Demographic factors, such as race, smoking status, and socioeconomic status, may confer an increased risk of susceptibility to these viruses...
  51. Phares T, Ramakrishna C, Parra G, Epstein A, Chen L, Atkinson R, et al. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol. 2009;182:5430-8 pubmed publisher
    ..However, the beneficial role of PD-1:B7-H1 interactions in limiting morbidity highlights the need to evaluate tissue-specific intervention strategies...
  52. Gaunt E, Hardie A, Claas E, Simmonds P, Templeton K. Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method. J Clin Microbiol. 2010;48:2940-7 pubmed publisher
  53. Zust R, Cervantes Barragan L, Habjan M, Maier R, Neuman B, Ziebuhr J, et al. Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol. 2011;12:137-43 pubmed publisher
    ..This link between Mda5-mediated sensing of viral RNA and 2'-O-methylation of mRNA suggests that RNA modifications such as 2'-O-methylation provide a molecular signature for the discrimination of self and non-self mRNA...