porcine reproductive and respiratory syndrome

Summary

Summary: A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)

Top Publications

  1. Lee Y, Lee C. Porcine reproductive and respiratory syndrome virus replication is suppressed by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. Virus Res. 2010;152:50-8 pubmed publisher
    ..However, to date, little is known about the intracellular signaling mechanisms involved in porcine reproductive and respiratory syndrome virus (PRRSV) replication...
  2. Ramamoorthy S, Opriessnig T, Pal N, Huang F, Meng X. Effect of an interferon-stimulated response element (ISRE) mutant of porcine circovirus type 2 (PCV2) on PCV2-induced pathological lesions in a porcine reproductive and respiratory syndrome virus (PRRSV) co-infection model. Vet Microbiol. 2011;147:49-58 pubmed publisher
    ..infect pigs with either ISRE mutant or wildtype PCV2 singly or in combination with porcine reproductive and respiratory syndrome virus (PRRSV)...
  3. Zhang Z, Wang Y, Fan H, Lu C. Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination. Arch Virol. 2012;157:927-33 pubmed publisher
    ..These data indicate that TTSuV1 natural infection has an adverse effect on the development of host immune responses, suppresses immunization by the PRRS MLV vaccine, and exacerbates PRRS to a certain extent in pigs. ..
  4. Kittawornrat A, Prickett J, Wang C, Olsen C, Irwin C, Panyasing Y, et al. Detection of Porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in oral fluid specimens using a commercial PRRSV serum antibody enzyme-linked immunosorbent assay. J Vet Diagn Invest. 2012;24:262-9 pubmed publisher
    ..a commercial serum antibody enzyme-linked immunosorbent assay (ELISA) modified to detect anti-Porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in pen-based oral fluid specimens...
  5. Dwivedi V, Manickam C, Binjawadagi B, Joyappa D, Renukaradhya G. Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs. PLoS ONE. 2012;7:e51794 pubmed publisher
    ..virus vaccine against an economically important respiratory viral disease of pigs called porcine reproductive and respiratory syndrome virus (PRRSV)...
  6. Liu D, Zhou R, Zhang J, Zhou L, Jiang Q, Guo X, et al. Recombination analyses between two strains of porcine reproductive and respiratory syndrome virus in vivo. Virus Res. 2011;155:473-86 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is characteristic of genetically extensive variation. In this study, five SPF pigs were co-infected with two strains of PRRSV (JXwn06-81c and HB-1/3...
  7. Shi X, Chen J, Xing G, Zhang X, Hu X, Zhi Y, et al. Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1? (nsp1?) as an inhibitor to the induction of IFN-?. Cell Immunol. 2012;280:125-31 pubmed publisher
    Previous studies have shown that porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 1? (nsp1?) was the interferon (IFN) antagonist. However, the mechanism was unclear...
  8. Gao L, Zhang W, Sun Y, Yang Q, Ren J, Liu J, et al. Cryptoporus volvatus extract inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro and in vivo. PLoS ONE. 2013;8:e63767 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an important arterivirus that can cause significant losses in swine industry. At present, there are no adequate control strategies against PRRSV...
  9. Reiner G, Willems H, Pesch S, Ohlinger V. Variation in resistance to the porcine reproductive and respiratory syndrome virus (PRRSV) in Pietrain and Miniature pigs. J Anim Breed Genet. 2010;127:100-6 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is one of the economically most important diseases of swine. Viraemia and the prolonged persistence of the virus are among the most critical factors...

More Information

Publications108 found, 100 shown here

  1. Darwich L, Diaz I, Mateu E. Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology. Virus Res. 2010;154:123-32 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most costly pathogens for the swine industry. Since its emergence some 20 years ago, much has been learned about the immunobiology of PRRSV...
  2. Calzada Nova G, Schnitzlein W, Husmann R, Zuckermann F. North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J Virol. 2011;85:2703-13 pubmed publisher
    ..IFN-α) by plasmacytoid dendritic cells (pDC), porcine pDC remain quiescent when exposed to porcine reproductive and respiratory syndrome virus (PRRSV)...
  3. Linhares D, Cano J, Wetzell T, Nerem J, Torremorell M, Dee S. Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs. Vaccine. 2012;30:407-13 pubmed publisher
    There are ongoing efforts to eliminate porcine reproductive and respiratory syndrome virus (PRRSv) from regions in the United States swine industry...
  4. Renukaradhya G, Alekseev K, Jung K, Fang Y, Saif L. Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs. Viral Immunol. 2010;23:457-66 pubmed publisher
    ..Pigs were either mock-infected or infected with porcine reproductive and respiratory syndrome virus (PRRSV), a virus known to cause immunosuppressive respiratory disease, and then pigs ..
  5. Heegaard P, Stockmarr A, Piñeiro M, Carpintero R, Lampreave F, Campbell F, et al. Optimal combinations of acute phase proteins for detecting infectious disease in pigs. Vet Res. 2011;42:50 pubmed publisher
    ..For the practical use of such combinations, methodology is described for establishing individual APP threshold values, above which, for any APP in the combination, ongoing infection/inflammation is indicated...
  6. Sun Z, Li Y, Ransburgh R, Snijder E, Fang Y. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol. 2012;86:3839-50 pubmed publisher
    ..In this study, we demonstrate that ISG15 overexpression inhibits porcine reproductive and respiratory syndrome virus (PRRSV) replication in cell culture and that the antiviral activity of interferon is ..
  7. Music N, Gagnon C. The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis. Anim Health Res Rev. 2010;11:135-63 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating viral disease affecting the swine industry worldwide...
  8. Faaberg K, Kehrli M, Lager K, Guo B, Han J. In vivo growth of porcine reproductive and respiratory syndrome virus engineered nsp2 deletion mutants. Virus Res. 2010;154:77-85 pubmed publisher
  9. Renukaradhya G, Dwivedi V, Manickam C, Binjawadagi B, BENFIELD D. Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective. Anim Health Res Rev. 2012;13:21-37 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is an economically important infectious disease of swine...
  10. Chai Z, Ma W, Fu F, Lang Y, Wang W, Tong G, et al. A SYBR Green-based real-time RT-PCR assay for simple and rapid detection and differentiation of highly pathogenic and classical type 2 porcine reproductive and respiratory syndrome virus circulating in China. Arch Virol. 2013;158:407-15 pubmed publisher
    ..RT-PCR assay was developed for simultaneous detection and differentiation of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) and classical type 2 PRRSV (C-PRRSV)...
  11. Ren X, Wang M, Yin J, Li G. Phages harboring specific peptides that recognize the N protein of the porcine reproductive and respiratory syndrome virus distinguish the virus from other viruses. J Clin Microbiol. 2010;48:1875-81 pubmed publisher
    The aim of the current study was to develop a novel diagnostic test for detecting porcine reproductive and respiratory syndrome virus (PRRSV) using phage display technology...
  12. Lambert M, Arsenault J, Poljak Z, D Allaire S. Epidemiological investigations in regard to porcine reproductive and respiratory syndrome (PRRS) in Quebec, Canada. Part 2: prevalence and risk factors in breeding sites. Prev Vet Med. 2012;104:84-93 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat for swine industry and understanding factors involved in its epidemiology is undoubtedly essential for disease control...
  13. Karniychuk U, De Spiegelaere W, Nauwynck H. Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal-fetal interface. Virus Res. 2013;176:285-91 pubmed publisher
    It is already known that porcine reproductive and respiratory syndrome virus (PRRSV) infection in lungs changes a local cell pattern and cytokine profile...
  14. Kvisgaard L, Hjulsager C, Kristensen C, Lauritsen K, Larsen L. Genetic and antigenic characterization of complete genomes of Type 1 Porcine Reproductive and Respiratory Syndrome viruses (PRRSV) isolated in Denmark over a period of 10 years. Virus Res. 2013;178:197-205 pubmed publisher
    b>Porcine Reproductive and Respiratory Syndrome (PRRS) caused by the PRRS virus (PRRSV) is considered one of the most devastating swine diseases worldwide...
  15. Cao J, Wang X, Du Y, Li Y, Wang X, Jiang P. CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine. Vaccine. 2010;28:7514-22 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) has recently caused heavy economic losses in swine industry worldwide...
  16. Lambert M, Poljak Z, Arsenault J, D Allaire S. Epidemiological investigations in regard to porcine reproductive and respiratory syndrome (PRRS) in Quebec, Canada. Part 1: biosecurity practices and their geographical distribution in two areas of different swine density. Prev Vet Med. 2012;104:74-83 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is a considerable threat to the swine industry and implementing biosecurity measures is essential for the control of its transmission...
  17. Cano J, Dee S, Murtaugh M, Rovira A, Morrison R. Infection dynamics and clinical manifestations following experimental inoculation of gilts at 90 days of gestation with a low dose of porcine reproductive and respiratory syndrome virus. Can J Vet Res. 2009;73:303-7 pubmed
    Understanding the dynamics of porcine reproductive and respiratory syndrome virus (PRRSV) vertical transmission is important to enhance the accuracy of monitoring protocols for endemically infected breeding herds...
  18. Chia M, Hsiao S, Chan H, Do Y, Huang P, Chang H, et al. The immunogenicity of DNA constructs co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus conjugated by GPGP linker in pigs. Vet Microbiol. 2010;146:189-99 pubmed publisher
    ..protein (M) is the leading target for the development of new generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV) infection...
  19. Huang L, Zhang Y, Yu Y, Sun M, Li C, Chen P, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011;414:545-50 pubmed publisher
    ..Cholesterol is a critical structural component of lipid rafts. Although the porcine reproductive and respiratory syndrome virus (PRRSV) has restricted cell tropism for cells of the monocyte/macrophage lineage, a non-..
  20. Kvisgaard L, Hjulsager C, Brar M, Leung F, Larsen L. Genetic dissection of complete genomes of Type 2 PRRS viruses isolated in Denmark over a period of 15 years. Vet Microbiol. 2013;167:334-44 pubmed publisher
    Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) was first detected in Europe in 1996 co-incident with the introduction of a live attenuated vaccine...
  21. Pitkin A, Deen J, Dee S. Further assessment of fomites and personnel as vehicles for the mechanical transport and transmission of porcine reproductive and respiratory syndrome virus. Can J Vet Res. 2009;73:298-302 pubmed
    ..re-evaluated the role of fomites and personnel in the mechanical transport and transmission of porcine reproductive and respiratory syndrome virus (PRRSV) between pig populations...
  22. Martinez Lobo F, Díez Fuertes F, Segales J, García Artiga C, Simarro I, Castro J, et al. Comparative pathogenicity of type 1 and type 2 isolates of porcine reproductive and respiratory syndrome virus (PRRSV) in a young pig infection model. Vet Microbiol. 2011;154:58-68 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) isolates are classified in two different genotypes, based on genomic heterogeneity: type 1, which comprises European type isolates, and type 2, which includes North American ..
  23. Balka G, Ladinig A, Ritzmann M, Saalmuller A, Gerner W, Kaser T, et al. Immunohistochemical characterization of type II pneumocyte proliferation after challenge with type I porcine reproductive and respiratory syndrome virus. J Comp Pathol. 2013;149:322-30 pubmed publisher
    ..developing in growing pigs, 10 and 21 days after experimental challenge with a field strain of porcine reproductive and respiratory syndrome virus (PRRSV)...
  24. Langenhorst R, Lawson S, Kittawornrat A, Zimmerman J, Sun Z, Li Y, et al. Development of a fluorescent microsphere immunoassay for detection of antibodies against porcine reproductive and respiratory syndrome virus using oral fluid samples as an alternative to serum-based assays. Clin Vaccine Immunol. 2012;19:180-9 pubmed publisher
    ..rapid and sensitive assays are needed to detect antibodies developed in response to porcine reproductive and respiratory syndrome virus (PRRSV) infection...
  25. Ni J, Yang S, Bounlom D, Yu X, Zhou Z, Song J, et al. Emergence and pathogenicity of highly pathogenic Porcine reproductive and respiratory syndrome virus in Vientiane, Lao People's Democratic Republic. J Vet Diagn Invest. 2012;24:349-54 pubmed publisher
    Highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS) characterized by high fever, high morbidity, and high mortality in pigs of all ages emerged in China in 2006 and spread rapidly throughout Southeast Asia...
  26. Opriessnig T, Gauger P, Faaberg K, Shen H, Beach N, Meng X, et al. Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model. Vet Microbiol. 2012;158:69-81 pubmed publisher
    ..determine differences in infection kinetics of two temporally and genetically different type 2 porcine reproductive and respiratory syndrome virus (PRRSV) isolates in vivo with and without concurrent porcine circovirus (PCV) type 2a or ..
  27. Chand R, Trible B, Rowland R. Pathogenesis of porcine reproductive and respiratory syndrome virus. Curr Opin Virol. 2012;2:256-63 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry...
  28. Karniychuk U, Saha D, Vanhee M, Geldhof M, Cornillie P, Caij A, et al. Impact of a novel inactivated PRRS virus vaccine on virus replication and virus-induced pathology in fetal implantation sites and fetuses upon challenge. Theriogenology. 2012;78:1527-37 pubmed publisher
    Preventing congenital infection is important for the control of porcine reproductive and respiratory syndrome (PRRS)...
  29. Badaoui B, Tuggle C, Hu Z, Reecy J, Ait Ali T, Anselmo A, et al. Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: a meta-analysis approach. BMC Genomics. 2013;14:220 pubmed publisher
    ..global immune response to different challenges, and ii) determined the specific response to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection...
  30. Johnson C, Griggs T, Gnanandarajah J, Murtaugh M. Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J Gen Virol. 2011;92:1107-16 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus that emerged in the late 1980s in both Europe and North America as the causative agent of porcine reproductive and respiratory syndrome (PRRS), now the most ..
  31. Li Y, Tas A, Snijder E, Fang Y. Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells. J Gen Virol. 2012;93:829-39 pubmed publisher
    The porcine reproductive and respiratory syndrome virus (PRRSV) replicase gene consists of two large ORFs, ORF1a and ORF1b, the latter of which is expressed by ribosomal frameshifting...
  32. Sun X, Wertz N, Lager K, Tobin G, Butler J. Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS Virus display the same immune dysregulation seen in isolator piglets. Vaccine. 2012;30:3646-52 pubmed publisher
    ..Ig levels and antibody repertoire diversification in fetal piglets infected with an attenuated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) were measured...
  33. Stadejek T, Stankevicius A, Murtaugh M, Oleksiewicz M. Molecular evolution of PRRSV in Europe: current state of play. Vet Microbiol. 2013;165:21-8 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to European swine production...
  34. Gómez Laguna J, Salguero F, Pallares F, Fernández de Marco M, Barranco I, Ceron J, et al. Acute phase response in porcine reproductive and respiratory syndrome virus infection. Comp Immunol Microbiol Infect Dis. 2010;33:e51-8 pubmed publisher
    ..CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1? (IL-1?)..
  35. Chia M, Hsiao S, Chan H, Do Y, Huang P, Chang H, et al. Immunogenicity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant. Vet Immunol Immunopathol. 2010;135:234-42 pubmed publisher
    ..was to evaluate the immunogenicity of the ORF5-encoded major envelop glycoprotein 5 (GP5) of porcine reproductive and respiratory syndrome virus (PRRSV) expressed in tobacco plant as a potential pig oral vaccine in protection against ..
  36. He D, Overend C, Ambrogio J, Maganti R, Grubman M, Garmendia A. Marked differences between MARC-145 cells and swine alveolar macrophages in IFN?-induced activation of antiviral state against PRRSV. Vet Immunol Immunopathol. 2011;139:57-60 pubmed publisher
    ..Therefore, studies to understand virus-host cell interactions performed in MARC-145 cells require additional scrutiny when utilized as a host cell model for immunologic responses to PRRSV. ..
  37. Fablet C, Marois Créhan C, Simon G, Grasland B, Jestin A, Kobisch M, et al. Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: a cross-sectional study. Vet Microbiol. 2012;157:152-63 pubmed publisher
    ..Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, swine influenza viruses (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) were detected by serological or PCR tests...
  38. Xiao S, Jia J, Mo D, Wang Q, Qin L, He Z, et al. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS ONE. 2010;5:e11377 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) has been one of the most economically important diseases affecting swine industry worldwide and causes great economic losses each year...
  39. Dee S, Otake S, Deen J. Use of a production region model to assess the efficacy of various air filtration systems for preventing airborne transmission of porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae: results from a 2-year study. Virus Res. 2010;154:177-84 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (M hyo) are economically significant pathogens of pigs that can be spread between herds via the airborne route...
  40. Leng X, Li Z, Xia M, Li X, Wang F, Wang W, et al. Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation. Vet Microbiol. 2012;157:50-60 pubmed publisher
    A live-attenuated highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS) virus (HP-PRRSV) TJM vaccine strain was derived from the HP-PRRSV TJ strain by passage 92 times in the African green monkey kidney epithelial ..
  41. Diaz I, Gimeno M, Darwich L, Navarro N, Kuzemtseva L, Lopez S, et al. Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection. Vet Res. 2012;43:30 pubmed publisher
    The present study characterized the homologous and heterologous immune response in type-I porcine reproductive and respiratory syndrome virus (PRRSV) infection...
  42. Silva Campa E, Mata Haro V, Mateu E, Hernandez J. Porcine reproductive and respiratory syndrome virus induces CD4+CD8+CD25+Foxp3+ regulatory T cells (Tregs). Virology. 2012;430:73-80 pubmed publisher
    The aim of this study was to analyze the regulatory T cells (Tregs) induced by the porcine reproductive and respiratory syndrome virus (PRRSV) in pigs...
  43. Ni Y, Zhao Z, Opriessnig T, Subramaniam S, Zhou L, Cao D, et al. Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus. Virology. 2014;450-451:132-9 pubmed publisher
    ..In this study, by using SAVE we demonstrated rapid attenuation of an arterivirus, porcine reproductive and respiratory syndrome virus (PRRSV)...
  44. Duinhof T, van Schaik G, van Esch E, Wellenberg G. Detection of PRRSV circulation in herds without clinical signs of PRRS: comparison of five age groups to assess the preferred age group and sample size. Vet Microbiol. 2011;150:180-4 pubmed publisher
    ..study was conducted to find the most effective diagnostic approach to detect circulation of porcine reproductive and respiratory syndrome virus (PRRSV)...
  45. Chia M, Hsiao S, Chan H, Do Y, Huang P, Chang H, et al. Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs. Vet Immunol Immunopathol. 2011;140:215-25 pubmed publisher
    ..Our previous study showed that the expression of neutralizing epitope GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) in transgenic tobacco plant (GP5-T) could induce PRRSV-specific immune responses ..
  46. Wei Z, Lin T, Sun L, Li Y, Wang X, Gao F, et al. N-linked glycosylation of GP5 of porcine reproductive and respiratory syndrome virus is critically important for virus replication in vivo. J Virol. 2012;86:9941-51 pubmed publisher
    It has been proposed that the N-linked glycan addition at certain sites in GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) is important for production of infectious viruses and viral infectivity...
  47. Du Y, Qi J, Lu Y, Wu J, Yoo D, Liu X, et al. Evaluation of a DNA vaccine candidate co-expressing GP3 and GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) with interferon ?/? in immediate and long-lasting protection against HP-PRRSV challenge. Virus Genes. 2012;45:474-87 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) has become one of the most economically important diseases to the global pork industry. Current vaccination strategies only provide a limited protective efficacy...
  48. Manickam C, Dwivedi V, Patterson R, Papenfuss T, Renukaradhya G. Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs. Vet Microbiol. 2013;162:68-77 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is a chronic viral disease of pigs caused by PRRS virus (PRRSV). The PRRSV VR2332 is the prototype North American parental strain commonly used in the preparation of vaccines...
  49. Han K, Seo H, Oh Y, Kang I, Park C, Ha B, et al. Pathogenesis of Korean type 1 (European genotype) porcine reproductive and respiratory syndrome virus in experimentally infected pregnant gilts. J Comp Pathol. 2013;148:396-404 pubmed publisher
    ..study were to determine (1) the pathogenesis of experimental infection with a Korean type 1 porcine reproductive and respiratory syndrome virus (PRRSV) by defining the viral distribution and the sites of viral replication and (2) ..
  50. Lunney J, Fritz E, Reecy J, Kuhar D, Prucnal E, Molina R, et al. Interleukin-8, interleukin-1beta, and interferon-gamma levels are linked to PRRS virus clearance. Viral Immunol. 2010;23:127-34 pubmed publisher
    Infection with porcine reproductive and respiratory syndrome virus (PRRSV) results in a weak antiviral immune response that leads to a persistent infection in a subset of pigs...
  51. Cruz J, Zúñiga S, Bécares M, Sola I, Ceriani J, Juanola S, et al. Vectored vaccines to protect against PRRSV. Virus Res. 2010;154:150-60 pubmed publisher
    ..Nevertheless, the level of neutralizing antibodies was low, what may explain the limited protection observed. Several strategies are proposed to improve current rTGEV vectors expressing PRRSV antigens...
  52. Zhou L, Yang H. Porcine reproductive and respiratory syndrome in China. Virus Res. 2010;154:31-7 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is an economically important viral disease for the pig industry worldwide...
  53. Wang Y, Luo R, Fang L, Wang D, Bi J, Chen H, et al. Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells. Mol Immunol. 2011;48:586-91 pubmed publisher
    ..Previous studies have demonstrated that infection with porcine reproductive and respiratory syndrome virus (PRRSV) induces RANTES transcription in vitro and in vivo...
  54. Lawson S, Li Y, Patton J, Langenhorst R, Sun Z, Jiang Z, et al. Interleukin-1? expression by a recombinant porcine reproductive and respiratory syndrome virus. Virus Res. 2012;163:461-8 pubmed publisher
    ..In this study, we constructed a recombinant porcine reproductive and respiratory syndrome virus (vP129/swIL1?) expressing swine IL-1? from the separate subgenomic mRNA inserted between ..
  55. Karniychuk U, Van Breedam W, Van Roy N, Rogel Gaillard C, Nauwynck H. Demonstration of microchimerism in pregnant sows and effects of congenital PRRSV infection. Vet Res. 2012;43:19 pubmed publisher
    ..the present investigation was to study if microchimerism occurs in healthy sows/fetuses and if porcine reproductive and respiratory syndrome virus (PRRSV) infection influences this phenomenon...
  56. Song S, Bi J, Wang D, Fang L, Zhang L, Li F, et al. Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-?B and p38 MAPK pathways in porcine alveolar macrophages. Dev Comp Immunol. 2013;39:265-72 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an emerging animal virus that has caused high economic losses for the swine industry worldwide...
  57. Gerber P, O Neill K, Owolodun O, Wang C, Harmon K, Zhang J, et al. Comparison of commercial real-time reverse transcription-PCR assays for reliable, early, and rapid detection of heterologous strains of porcine reproductive and respiratory syndrome virus in experimentally infected or noninfected boars by use of diff. J Clin Microbiol. 2013;51:547-56 pubmed publisher
    The aims of this study were to compare three commercial porcine reproductive and respiratory syndrome virus (PRRSV) real-time reverse transcription-PCR (RT-PCR) assays for detection of genetically diverse PRRSV isolates in serum, semen, ..
  58. Diaz I, Ganges L, Galindo Cardiel I, Tarradas J, Alvarez B, Lorca Oró C, et al. Immunization with DNA vaccines containing porcine reproductive and respiratory syndrome virus open reading frames 5, 6, and 7 may be related to the exacerbation of clinical disease after an experimental challenge. Viral Immunol. 2013;26:93-101 pubmed publisher
    Pigs were immunized with DNA plasmids containing different open reading frames (ORFs) of a porcine reproductive and respiratory syndrome virus (PRRSV) genotype I strain...
  59. Li Y, Xue C, Wang L, Chen X, Chen F, Cao Y. Genomic analysis of two Chinese strains of porcine reproductive and respiratory syndrome viruses with different virulence. Virus Genes. 2010;40:374-81 pubmed publisher
    Two strains of porcine reproductive and respiratory syndrome virus (PRRSV) were isolated, designated GDQJ and GDBY1...
  60. Jung K, Gurnani A, Renukaradhya G, Saif L. Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol. 2010;136:335-9 pubmed publisher
    ..lavage (BAL) of pigs infected with either porcine respiratory coronavirus (PRCV) or porcine reproductive and respiratory syndrome virus (PRRSV), a member of Nidovirales, like CoV...
  61. Subramaniam S, Sur J, Kwon B, Pattnaik A, Osorio F. A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo. Virus Res. 2011;155:415-22 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failure and respiratory illness in infected pigs...
  62. Hao X, Lu Z, Kuang W, Sun P, Fu Y, Wu L, et al. Polymorphic genetic characterization of the ORF7 gene of porcine reproductive and respiratory syndrome virus (PRRSV) in China. Virol J. 2011;8:73 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) exhibits extensive genetic variation. The outbreak of a highly pathogenic PRRS in 2006 led us to investigate the extent of PRRSV genetic diversity in China...
  63. Dwivedi V, Manickam C, Patterson R, Dodson K, Weeman M, Renukaradhya G. Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs. Vaccine. 2011;29:4067-76 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease to pork producers worldwide. Commercially, both live and killed PRRSV vaccines are available to control PRRS, but they are not always successful...
  64. Nieuwenhuis N, Duinhof T, van Nes A. Economic analysis of outbreaks of porcine reproductive and respiratory syndrome virus in nine sow herds. Vet Rec. 2012;170:225 pubmed publisher
    The economic losses due to porcine reproductive and respiratory syndrome virus (PRRSv) outbreaks are reported in the literature to be substantially high, but recent figures are not available...
  65. Zhou A, Zhang S. Regulation of cell signaling and porcine reproductive and respiratory syndrome virus. Cell Signal. 2012;24:973-80 pubmed publisher
    In order to successfully survive in host and persistent infection, porcine reproductive and respiratory syndrome virus (PRRSV) utilized sophisticated mechanisms to suppress or escape from the host' innate and adaptive immune systems, and ..
  66. De Baere M, Van Gorp H, Delputte P, Nauwynck H. Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis. Vet Res. 2012;43:47 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus that shows a restricted in vivo tropism for subsets of porcine macrophages, with alveolar macrophages being major target cells...
  67. Shi Y, Hu Z, Xiong Z, Zhou Y, Jin X, Gu C, et al. Analysis of molecular variation of porcine reproductive and respiratory syndrome virus in Central China from 2006 to 2012. Arch Virol. 2013;158:717-21 pubmed publisher
    ..Furthermore, we found that the number of potential N-glycosylation sites had apparently increased since 2006. These findings increase our knowledge of PRRSV epidemiology in Central China...
  68. Nilubol D, Tripipat T, Hoonsuwan T, Kortheerakul K. Porcine reproductive and respiratory syndrome virus, Thailand, 2010-2011. Emerg Infect Dis. 2012;18:2039-43 pubmed publisher
    Characterization of porcine reproductive and respiratory syndrome virus (PRRSV) isolates from pigs in Thailand showed 30-aa discontinuous deletions in nonstructural protein 2, identical to sequences for highly pathogenic PRRSV...
  69. Morgan S, Graham S, Salguero F, Sánchez Cordón P, Mokhtar H, Rebel J, et al. Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance. Vet Microbiol. 2013;163:13-22 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine worldwide...
  70. Kvisgaard L, Hjulsager C, Fahnøe U, Breum S, Ait Ali T, Larsen L. A fast and robust method for full genome sequencing of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Type 1 and Type 2. J Virol Methods. 2013;193:697-705 pubmed publisher
    ..These methods will greatly facilitate the generation of more full genome PRRSV sequences globally. ..
  71. Van Gorp H, Van Breedam W, Van Doorsselaere J, Delputte P, Nauwynck H. Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus. J Virol. 2010;84:3101-5 pubmed publisher
    Scavenger receptor CD163 is a key entry mediator for porcine reproductive and respiratory syndrome virus (PRRSV). To identify the CD163 protein domains involved in PRRSV infection, deletion mutants and chimeric mutants were created...
  72. Murtaugh M, Stadejek T, Abrahante J, Lam T, Leung F. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res. 2010;154:18-30 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) virus appeared 20 years ago as the cause of a new disease in swine. Today PRRS is the most significant swine disease worldwide in spite of intensive immunological interventions...
  73. Rowland R. The interaction between PRRSV and the late gestation pig fetus. Virus Res. 2010;154:114-22 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta during late gestation and productively infects the fetus...
  74. Shi M, Lam T, Hon C, Hui R, Faaberg K, Wennblom T, et al. Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res. 2010;154:7-17 pubmed publisher
    Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry...
  75. Chittick W, Stensland W, Prickett J, Strait E, Harmon K, Yoon K, et al. Comparison of RNA extraction and real-time reverse transcription polymerase chain reaction methods for the detection of Porcine reproductive and respiratory syndrome virus in porcine oral fluid specimens. J Vet Diagn Invest. 2011;23:248-53 pubmed
    ..various RNA extraction and polymerase chain reaction (PCR) protocols for the detection of Porcine reproductive and respiratory syndrome virus (PRRSV) in porcine oral fluids...
  76. Che T, Johnson R, Kelley K, Van Alstine W, Dawson K, Moran C, et al. Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus. J Anim Sci. 2011;89:3016-29 pubmed publisher
    ..fluid (BALF) cells from control- or mannan oligosaccharide (MOS)-fed pigs with or without porcine reproductive and respiratory syndrome virus (PRRSV) at d 7 postinfection (PI). Weaned pigs (3 wk old) fed 0 or 0...
  77. Ding Z, Li Z, Zhang X, Li Y, Liu C, Zhang Y, et al. Proteomic alteration of Marc-145 cells and PAMs after infection by porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol. 2012;145:206-13 pubmed publisher
    ..To uncover cellular protein responses in porcine reproductive and respiratory syndrome virus (PRRSV), infected pulmonary alveolar macrophages (PAMs) and Marc-145 cells were ..
  78. Lambert M, Arsenault J, Poljak Z, D Allaire S. Correlation among genetic, Euclidean, temporal, and herd ownership distances of porcine reproductive and respiratory syndrome virus strains in Quebec, Canada. BMC Vet Res. 2012;8:76 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is a viral disease that has a major economic impact for the swine industry...
  79. He Y, Wang G, Liu Y, Shi W, Han Z, Wu J, et al. Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2012;160:455-62 pubmed publisher
    ..These results suggested that HP-PRRSV induced abundant apoptosis might result in severe thymus atrophy and the depletion of thymocytes...
  80. Yu X, Chen N, Deng X, Cao Z, Han W, Hu D, et al. Genomic sequencing reveals mutations potentially related to the overattenuation of a highly pathogenic porcine reproductive and respiratory syndrome virus. Clin Vaccine Immunol. 2013;20:613-9 pubmed publisher
    Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to evolve when serially passaged in Marc-145 cells...
  81. Wang R, Nan Y, Yu Y, Zhang Y. Porcine reproductive and respiratory syndrome virus Nsp1? inhibits interferon-activated JAK/STAT signal transduction by inducing karyopherin-?1 degradation. J Virol. 2013;87:5219-28 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the interferon-mediated antiviral response...
  82. Ma Z, Wang Y, Zhao H, Xu A, Wang Y, Tang J, et al. Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity. PLoS ONE. 2013;8:e69387 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in pigs caused by PRRS virus (PRRSV). Although PRRSV infection-induced cell apoptosis has been established, the related viral protein is still unknown...
  83. Ait Ali T, Wilson A, Carre W, Westcott D, Frossard J, Mellencamp M, et al. Host inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response. Immunogenetics. 2011;63:437-48 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by a positive RNA strand arterivirus. PRRS virus (PRRSV) interacts primarily with lung macrophages...
  84. Li B, Fang L, Guo X, Gao J, Song T, Bi J, et al. Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010. J Clin Microbiol. 2011;49:3175-83 pubmed publisher
    In 2006, an emerging highly pathogenic strain of porcine reproductive and respiratory syndrome virus (PRRSV), which causes continuous high fever and a high proportion of deaths in vaccinated pigs of all ages, broke out in mainland China ..
  85. Zhang S, Zhou Y, Jiang Y, Li G, Yan L, Yu H, et al. Generation of an infectious clone of HuN4-F112, an attenuated live vaccine strain of porcine reproductive and respiratory syndrome virus. Virol J. 2011;8:410 pubmed publisher
    ..In this regard, HuN4-F112, a live-attenuated North-American-type PRRSV vaccine strain, could serve as an excellent model...
  86. Weesendorp E, Morgan S, Stockhofe Zurwieden N, Popma De Graaf D, Graham S, Rebel J. Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence. Vet Microbiol. 2013;163:1-12 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is difficult to control due to a high mutation rate and the emergence of virulent strains...
  87. Jiang Z, Zhou X, Michal J, Wu X, Zhang L, Zhang M, et al. Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS ONE. 2013;8:e59229 pubmed publisher
    b>Porcine reproductive and respiratory syndrome (PRRS) has devastated pig industries worldwide for many years. It is caused by a small RNA virus (PRRSV), which targets almost exclusively pig monocytes or macrophages...
  88. Li X, Galliher Beckley A, Huang H, Sun X, Shi J. Peptide nanofiber hydrogel adjuvanted live virus vaccine enhances cross-protective immunity to porcine reproductive and respiratory syndrome virus. Vaccine. 2013;31:4508-15 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is prevalent in swine farms worldwide and is a major source of economic loss and animal suffering...
  89. Liu Y, Zhou J, Chen H, Ma L, Ding Y, Wang M, et al. Analysis of synonymous codon usage in porcine reproductive and respiratory syndrome virus. Infect Genet Evol. 2010;10:797-803 pubmed publisher
    ..of codon usage pattern of open reading frames (ORFs) which belong to the two main genotypes of porcine reproductive and respiratory syndrome virus (PRRSV)...
  90. Tian H, Wu J, Shang Y, Cheng Y, Liu X. The development of a rapid SYBR one step real-time RT-PCR for detection of Porcine Reproductive and Respiratory Syndrome Virus. Virol J. 2010;7:90 pubmed publisher
    ..quantitative reverse transcription PCR (qRT-PCR) has been developed for the detection of porcine reproductive and respiratory syndrome virus (PRRSV)...
  91. Yu J, Wu J, Zhang Y, Guo L, Cong X, Du Y, et al. Concurrent highly pathogenic porcine reproductive and respiratory syndrome virus infection accelerates Haemophilus parasuis infection in conventional pigs. Vet Microbiol. 2012;158:316-21 pubmed publisher
    This study was aimed at determining the effect of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) on Haemophilus parasuis (HPS) in co-infection...
  92. Delisle B, Gagnon C, Lambert M, D Allaire S. Porcine reproductive and respiratory syndrome virus diversity of Eastern Canada swine herds in a large sequence dataset reveals two hypervariable regions under positive selection. Infect Genet Evol. 2012;12:1111-9 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is known to be genetically highly variable, but knowledge of sequence diversity from Eastern Canada and its degree of genetic plasticity in or near the principal neutralizing ..