rhabdoviridae infections

Summary

Summary: Virus diseases caused by RHABDOVIRIDAE. Important infections include RABIES; EPHEMERAL FEVER; and vesicular stomatitis.

Top Publications

  1. Zou J, Tafalla C, Truckle J, Secombes C. Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates. J Immunol. 2007;179:3859-71 pubmed
    ..The data overall support the concept that different vertebrate groups have independently expanded their IFN types, with deletion of different pairs of cysteines apparent in fish group I IFN and IFN-betaepsilon of mammals...
  2. Horton D, McElhinney L, Marston D, Wood J, Russell C, Lewis N, et al. Quantifying antigenic relationships among the lyssaviruses. J Virol. 2010;84:11841-8 pubmed publisher
    ..The use of passive immune globulin is a crucial component of rabies postexposure prophylaxis, and here we also show that it is possible to predict the reactivity of immune globulin against divergent lyssaviruses. ..
  3. Garver K, LaPatra S, Kurath G. Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon. Dis Aquat Organ. 2005;64:13-22 pubmed
    ..0 and 0.1 pg doses of the DNA vaccine, and vaccinated fish responded to viral challenges with higher antibody titers than mock-vaccinated control fish. ..
  4. Xu G, Weber P, Hu Q, Xue H, Audry L, Li C, et al. A simple sandwich ELISA (WELYSSA) for the detection of lyssavirus nucleocapsid in rabies suspected specimens using mouse monoclonal antibodies. Biologicals. 2007;35:297-302 pubmed
    ..8 ng/ml). With a panel of 1030 specimens received for rabies diagnostic testing, this test was found to be highly specific (0.999) and sensitive (0.970) when compared to other recommended rabies diagnostic methods. ..
  5. Sabeta C, Blumberg L, Miyen J, Mohale D, Shumba W, Wandeler A. Mokola virus involved in a human contact (South Africa). FEMS Immunol Med Microbiol. 2010;58:85-90 pubmed publisher
  6. Gomes Leal W, Martins L, Diniz J, Dos Santos Z, Borges J, Macedo C, et al. Neurotropism and neuropathological effects of selected rhabdoviruses on intranasally-infected newborn mice. Acta Trop. 2006;97:126-39 pubmed
    ..These results showed that viruses belonging to the Rhabdoviridae family possess distinct tropism for CNS structures and induce different pattern of cell death depending on the CNS region. ..
  7. Dzikwi A, Kuzmin I, Umoh J, Kwaga J, Ahmad A, Rupprecht C. Evidence of Lagos bat virus circulation among Nigerian fruit bats. J Wildl Dis. 2010;46:267-71 pubmed
    ..No neutralizing activity was detected against other lyssaviruses including rabies, Duvenhage, and West Caucasian bat viruses. ..
  8. Brookes S, Healy D, Fooks A. Ability of rabies vaccine strains to elicit cross-neutralising antibodies. Dev Biol (Basel). 2006;125:185-93 pubmed
    ..The continuing occurrence of non-classical lyssaviruses in Europe emphasizes the need for continual surveillance of bats and other species. ..
  9. Harris S, Aegerter J, Brookes S, McElhinney L, Jones G, Smith G, et al. Targeted surveillance for European bat lyssaviruses in English bats (2003-06). J Wildl Dis. 2009;45:1030-41 pubmed
    ..These data show that EBLV-2 is present in M. daubentonii in England. In contrast, there is insufficient evidence to suggest that EBLV-1 is present in E. serotinus in England, although further research is warranted. ..

More Information

Publications89

  1. Ooi E, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, et al. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008;32:1211-20 pubmed publisher
    ..Expression of the IFN-gamma and interleukin-1beta genes was not significantly increased. Thus, a salmonid rIFN-alpha can modulate the innate immune response of rainbow trout and mediate early antiviral protection against IHNV. ..
  2. Jakava Viljanen M, Lilley T, Kyheröinen E, Huovilainen A. First encounter of European bat lyssavirus type 2 (EBLV-2) in a bat in Finland. Epidemiol Infect. 2010;138:1581-5 pubmed publisher
    ..Phylogenetic analyses showed that the EBLV-2b isolate from the human case in 1985 and the isolate from the bat in 2009 were genetically closely related, demonstrating that EBLV-2 may have been circulating in Finland for many years. ..
  3. López Muñoz A, Roca F, Meseguer J, Mulero V. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol. 2009;182:3440-9 pubmed publisher
    ..Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections. ..
  4. Chadha M, Arankalle V, Jadi R, Joshi M, Thakare J, Mahadev P, et al. An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India. Am J Trop Med Hyg. 2005;73:566-70 pubmed
    ..The etiologic agent was Chandipura virus, which has become an important encephalitis-causing virus in India. ..
  5. Hayman D, Fooks A, Rowcliffe J, McCrea R, Restif O, Baker K, et al. Endemic Lagos bat virus infection in Eidolon helvum. Epidemiol Infect. 2012;140:2163-71 pubmed publisher
    ..These key findings point towards acute transmission of bat lyssaviruses in adapted bat hosts that occurs at a far higher rate than the occurrence of disease. ..
  6. Kim R, Faisal M. Comparative susceptibility of representative Great Lakes fish species to the North American viral hemorrhagic septicemia virus Sublineage IVb. Dis Aquat Organ. 2010;91:23-34 pubmed publisher
    ..These results highlight the variations among fish species susceptibility to this emerging strain of VHSV and offer insights into the potential impact of VHSV-IVb on the Laurentian Great Lakes fish community. ..
  7. Genz B, Nolden T, Negatsch A, Teifke J, Conzelmann K, Finke S. Chimeric rabies viruses for trans-species comparison of lyssavirus glycoprotein ectodomain functions in virus replication and pathogenesis. Berl Munch Tierarztl Wochenschr. 2012;125:219-27 pubmed
    ..The "envelope-switched" RABV therefore represent an important tool to further investigate the influence of lyssavirus ectodomains on virus tropism, and pathogenicity. ..
  8. Tjørnehøj K, Fooks A, Agerholm J, Rønsholt L. Natural and experimental infection of sheep with European bat lyssavirus type-1 of Danish bat origin. J Comp Pathol. 2006;134:190-201 pubmed
    ..It was speculated that the immune response prevented viral dissemination to the brain, resulting in an abortive peripheral infection. It was concluded that EBLV-1 can infect sheep under natural conditions as an incidental event. ..
  9. Purcell M, Laing K, Woodson J, Thorgaard G, Hansen J. Characterization of the interferon genes in homozygous rainbow trout reveals two novel genes, alternate splicing and differential regulation of duplicated genes. Fish Shellfish Immunol. 2009;26:293-304 pubmed publisher
    ..The specificity of the qRT-PCR assays reported here will be useful for future studies aimed at identifying which cells produce IFNs at early time points after infection. ..
  10. Hoffmann B, Beer M, Schutze H, Mettenleiter T. Fish rhabdoviruses: molecular epidemiology and evolution. Curr Top Microbiol Immunol. 2005;292:81-117 pubmed
  11. Walker P, Dietzgen R, Joubert D, Blasdell K. Rhabdovirus accessory genes. Virus Res. 2011;162:110-25 pubmed publisher
  12. Saint Jean S, Pérez Prieto S. Interferon mediated antiviral activity against salmonid fish viruses in BF-2 and other cell lines. Vet Immunol Immunopathol. 2006;110:1-10 pubmed
    ..On the basis of our findings, we conclude that the BF-2 cell line is a useful model in which to study the role of IFN-induced cytokines in resistance against single or double infections with salmonid fish viruses. ..
  13. Irie T, Harty R. L-domain flanking sequences are important for host interactions and efficient budding of vesicular stomatitis virus recombinants. J Virol. 2005;79:12617-22 pubmed
    ..We demonstrate that the composition of amino acids surrounding the L-domain core motifs are critical for efficient L-domain activity and for interactions with host proteins in the context of a VSV infection. ..
  14. Koraka P, Martina B, Roose J, van Thiel P, van Amerongen G, Kuiken T, et al. In vitro and in vivo isolation and characterization of Duvenhage virus. PLoS Pathog. 2012;8:e1002682 pubmed publisher
    ..This is the first study to describe the in vitro and in vivo isolation and characterization of DUVV. ..
  15. Markotter W, Kuzmin I, Rupprecht C, Randles J, Sabeta C, Wandeler A, et al. Isolation of Lagos bat virus from water mongoose. Emerg Infect Dis. 2006;12:1913-8 pubmed
  16. Utke K, Bergmann S, Lorenzen N, Köllner B, Ototake M, Fischer U. Cell-mediated cytotoxicity in rainbow trout, Oncorhynchus mykiss, infected with viral haemorrhagic septicaemia virus. Fish Shellfish Immunol. 2007;22:182-96 pubmed
    ..This is contradictory to the generally accepted rule that innate immune mechanisms represent the first line of defence after viral infections. ..
  17. Johnson N, Vos A, Neubert L, Freuling C, Mansfield K, Kaipf I, et al. Experimental study of European bat lyssavirus type-2 infection in Daubenton's bats (Myotis daubentonii). J Gen Virol. 2008;89:2662-72 pubmed publisher
    ..We conclude that EBLV-2 is most likely transmitted in saliva by a shallow bite. ..
  18. Franka R, Johnson N, Muller T, Vos A, Neubert L, Freuling C, et al. Susceptibility of North American big brown bats (Eptesicus fuscus) to infection with European bat lyssavirus type 1. J Gen Virol. 2008;89:1998-2010 pubmed publisher
    ..d.) routes could lead to an abortive infection and serve as a natural mode of immunization resulting in the presence of virus-neutralizing antibodies in free-ranging bats. ..
  19. Basak S, Mondal A, Polley S, Mukhopadhyay S, Chattopadhyay D. Reviewing Chandipura: a vesiculovirus in human epidemics. Biosci Rep. 2007;27:275-98 pubmed
    ..Finally, we reveal examples of protein economy in Chandipura virus life-cycle whereby each viral protein has evolved complexity to perform multiple tasks...
  20. Tripathy A, Balaji S, Rao N, Thakare J, Mishra A, Arankalle V. Cytokine levels in Chandipura virus associated encephalopathy in children. Scand J Infect Dis. 2005;37:590-3 pubmed
    ..1+/-472.5 vs 113.4.+/-148.3, p = 0.01, 486.2+/-145.7 vs 113.8+/-82.4, p = 0.003). Cytokine levels were not significantly different in Groups A and B...
  21. Brookes S, Klopfleisch R, Muller T, Healy D, Teifke J, Lange E, et al. Susceptibility of sheep to European bat lyssavirus type-1 and -2 infection: a clinical pathogenesis study. Vet Microbiol. 2007;125:210-23 pubmed
    ..This study suggests that inter-species animal-to-animal transmission of a bat variant of rabies virus to a terrestrial mammal host may be limited, and may not always result in fatal encephalitis...
  22. Chen H, Liu H, Liu Z, He J, Gao L, Shi X, et al. Characterization of the complete genome sequence of pike fry rhabdovirus. Arch Virol. 2009;154:1489-94 pubmed publisher
    ..3 to 91.4%. Phylogenetic analysis of the five proteins showed that PFRV clusters with SVCV and is closely related to the mammalian vesiculoviruses, 903/87, STRV and SCRV...
  23. Nel L. Vaccines for lyssaviruses other than rabies. Expert Rev Vaccines. 2005;4:533-40 pubmed
    ..The crossprotection of phylogroup 1 viruses by rabies vaccines and the development of new, broader range or specific vaccines for phylogroup 2 viruses are reviewed...
  24. Wargo A, Garver K, Kurath G. Virulence correlates with fitness in vivo for two M group genotypes of Infectious hematopoietic necrosis virus (IHNV). Virology. 2010;404:51-8 pubmed publisher
    ..There was no effect of competition on the performance of either genotype. Our results suggest a positive link between IHNV genotype fitness and virulence...
  25. Hayman D, Banyard A, Wakeley P, Harkess G, Marston D, Wood J, et al. A universal real-time assay for the detection of Lyssaviruses. J Virol Methods. 2011;177:87-93 pubmed publisher
    ..The single universal primer pair was therefore able to detect each of the most divergent known Lyssaviruses with great sensitivity...
  26. Dacheux L, Larrous F, Mailles A, Boisseleau D, Delmas O, Biron C, et al. European bat Lyssavirus transmission among cats, Europe. Emerg Infect Dis. 2009;15:280-4 pubmed
    ..We identified 2 cases of European bat lyssavirus subtype 1 transmission to domestic carnivores (cats) in France. Bat-to-cat transmission is suspected. Low amounts of virus antigen in cat brain made diagnosis difficult...
  27. Gubala A, Davis S, Weir R, Melville L, Cowled C, Boyle D. Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization, evolution of novel genes and seroprevalence in Australian livestock. J Gen Virol. 2011;92:2160-70 pubmed publisher
  28. Biacchesi S, Lamoureux A, Merour E, Bernard J, Bremont M. Limited interference at the early stage of infection between two recombinant novirhabdoviruses: viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus. J Virol. 2010;84:10038-50 pubmed publisher
  29. van der Poel W, van der Heide R, Verstraten E, Takumi K, Lina P, Kramps J. European bat lyssaviruses, The Netherlands. Emerg Infect Dis. 2005;11:1854-9 pubmed
    ..Since EBLVs can cause fatal infections in humans, all serotine and pond bats involved in contact incidents should be tested to determine whether the victim was exposed to EBLVs...
  30. Gurav Y, Tandale B, Jadi R, Gunjikar R, Tikute S, Jamgaonkar A, et al. Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007. Indian J Med Res. 2010;132:395-9 pubmed
    ..7%) and diarrhoea (23.7%). CHPV RNA was detected in one of two pools of sandflies from affected locality. Chandipura virus was confirmed as the aetiological agent of this acute encephalitis outbreak with high case-fatality among children...
  31. Venkateswarlu C, Arankalle V. Recombinant glycoprotein based vaccine for Chandipura virus infection. Vaccine. 2009;27:2845-50 pubmed publisher
    ..There was 60% T cell proliferation observed against rGp in immunized mice. The study shows that rGp induces both arms of immune response and represents an ideal vaccine candidate for further evaluations...
  32. Sabeta C, Markotter W, Mohale D, Shumba W, Wandeler A, Nel L. Mokola virus in domestic mammals, South Africa. Emerg Infect Dis. 2007;13:1371-3 pubmed publisher
    ..Our findings emphasize the endemicity of rabies-related lyssaviruses in South Africa and the need to better understand the epidemiology of Mokola viruses...
  33. Alonso M, Chiou P, Leong J. Development of a suicidal DNA vaccine for infectious hematopoietic necrosis virus (IHNV). Fish Shellfish Immunol. 2011;30:815-23 pubmed publisher
    ..We also demonstrated the protective immunity elicited by the suicidal DNA vaccine pIRF1A-G-pMT-M, the survival of fish after treatment with ZnCl(2), and the elimination of the suicidal vector in fish after ZnCl(2) treatment...
  34. Harmache A, LeBerre M, Droineau S, Giovannini M, Bremont M. Bioluminescence imaging of live infected salmonids reveals that the fin bases are the major portal of entry for Novirhabdovirus. J Virol. 2006;80:3655-9 pubmed
    ..We provide here evidence that the fin bases are the portal of entry into the fish. Confirmation was brought by the use of a nonpathogenic rIHNV, which was shown to persist in fins for 3 weeks postinfection...
  35. Elsayed E, Faisal M, Thomas M, Whelan G, Batts W, Winton J. Isolation of viral haemorrhagic septicaemia virus from muskellunge, Esox masquinongy (Mitchill), in Lake St Clair, Michigan, USA reveals a new sublineage of the North American genotype. J Fish Dis. 2006;29:611-9 pubmed
  36. Amengual B, Bourhy H, López Roig M, Serra Cobo J. Temporal dynamics of European bat Lyssavirus type 1 and survival of Myotis myotis bats in natural colonies. PLoS ONE. 2007;2:e566 pubmed
    ..A greater understanding of the dynamics of lyssavirus in bat colonies also provides a model to study how bats contribute to the maintenance and transmission of other viruses of public health concern...
  37. Paweska J, Blumberg L, Liebenberg C, Hewlett R, Grobbelaar A, Leman P, et al. Fatal human infection with rabies-related Duvenhage virus, South Africa. Emerg Infect Dis. 2006;12:1965-7 pubmed
    ..This occurred approximately 80 km from the site where the only other known human infection with the virus had occurred 36 years earlier...
  38. Wright E, Hayman D, Vaughan A, Temperton N, Wood J, Cunningham A, et al. Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses. Virology. 2010;408:183-9 pubmed publisher
    ..helvum remains high enough to persist in this species. This supports the hypothesis that LBV is endemic in Ghanaian E. helvum and we speculate that LBV may have co-evolved with African megachiroptera...
  39. Markotter W, van Eeden C, Kuzmin I, Rupprecht C, Paweska J, Swanepoel R, et al. Epidemiology and pathogenicity of African bat lyssaviruses. Dev Biol (Basel). 2008;131:317-25 pubmed
    ..In contrast, individual isolates of Lagos bat virus were found to differ significantly with respectto nucleoprotein gene nucleotide sequence diversity as well as in pathogenicity profiles...
  40. Johnson N, Phillpotts R, Fooks A. Airborne transmission of lyssaviruses. J Med Microbiol. 2006;55:785-90 pubmed
    ..This could present a particular hazard to personnel exposed to aerosols of infectious RABV following accidental release in a laboratory environment...
  41. Irie T, Carnero E, Okumura A, Garcia Sastre A, Harty R. Modifications of the PSAP region of the matrix protein lead to attenuation of vesicular stomatitis virus in vitro and in vivo. J Gen Virol. 2007;88:2559-67 pubmed
    ..These findings indicate an important role for the PSAP region (aa 33-44) of the M protein in the pathology of VSV infection and may have implications for the development of VSV as a vaccine and/or oncolytic vector...
  42. Kuzmin I, Novella I, Dietzgen R, Padhi A, Rupprecht C. The rhabdoviruses: biodiversity, phylogenetics, and evolution. Infect Genet Evol. 2009;9:541-53 pubmed publisher
    ..Ongoing progress in viral evolutionary and ecological investigations will provide the platform for future studies of this diverse family...
  43. Purcell M, LaPatra S, Woodson J, Kurath G, Winton J. Early viral replication and induced or constitutive immunity in rainbow trout families with differential resistance to Infectious hematopoietic necrosis virus (IHNV). Fish Shellfish Immunol. 2010;28:98-105 pubmed publisher
    ..In summary, disease outcome for each family was determined very early in the infection process and resistance was associated with lower early viral replication...
  44. Megali A, Yannic G, Zahno M, Brugger D, Bertoni G, Christe P, et al. Surveillance for European bat lyssavirus in Swiss bats. Arch Virol. 2010;155:1655-62 pubmed publisher
    ..Three M. daubentoni bats were found to be seropositive by RFFIT. In conclusion, even though the prevalence is low in Switzerland, continuous management and surveillance are required to assess the potential risk to public health...
  45. Park J, Moon C, Wargo A, Purcell M, Kurath G. Differential growth of U and M type infectious haematopoietic necrosis virus in a rainbow trout-derived cell line, RTG-2. J Fish Dis. 2010;33:583-91 pubmed publisher
    ..This suggests that host-specific factors in RTG-2 cells control the growth of the IHNV U and M strains differently, leading to growth restriction of the U type virus during the RNA synthesis step...
  46. Fu Z. Genetic comparison of the rhabdoviruses from animals and plants. Curr Top Microbiol Immunol. 2005;292:1-24 pubmed
  47. Kurath G, Garver K, Corbeil S, Elliott D, Anderson E, LaPatra S. Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout. Vaccine. 2006;24:345-54 pubmed
    ..Examination of multiple tissues showed an absence of detectable long-term histopathological damage due to DNA vaccination...
  48. Quillet E, Dorson M, Le Guillou S, Benmansour A, Boudinot P. Wide range of susceptibility to rhabdoviruses in homozygous clones of rainbow trout. Fish Shellfish Immunol. 2007;22:510-9 pubmed
    ..Although VHSV-resistant clones were not fully resistant to IHNV, the susceptibility to IHNV and VHSV tended to be correlated, suggesting that non-specific mechanisms common to both viruses were involved...
  49. Rieder M, Conzelmann K. Rhabdovirus evasion of the interferon system. J Interferon Cytokine Res. 2009;29:499-509 pubmed publisher
    ..The molecular mechanisms employed are different from those of the paramyxovirus P gene products serving similar functions, and illustrate evolution of IFN antagonists to specifically support virus survival in the natural niches...
  50. Peñaranda M, Purcell M, Kurath G. Differential virulence mechanisms of infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss) include host entry and virus replication kinetics. J Gen Virol. 2009;90:2172-82 pubmed publisher
    ..Taken together, the results support a kinetics hypothesis wherein faster replication enables M IHNV to rapidly achieve a threshold level of virus necessary to override the strong host innate immune response...
  51. Ivanov I, Yabukarski F, Ruigrok R, Jamin M. Structural insights into the rhabdovirus transcription/replication complex. Virus Res. 2011;162:126-37 pubmed publisher
  52. Detje C, Meyer T, Schmidt H, Kreuz D, Rose J, Bechmann I, et al. Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol. 2009;182:2297-304 pubmed publisher
    ..Our data indicate that upon intranasal VSV instillation, early and localized IFNAR triggering in the glomerular layer of the olfactory bulb is critically required to prevent viral spread over the entire CNS and thus confers survival...
  53. Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes C, et al. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss). J Virol. 2011;85:8403-12 pubmed publisher
    ..Interestingly, MDA5 expression was not affected by overexpressed LGP2 in transfected cells and vice versa, suggesting that they likely act in parallel as positive regulators for IFN production...
  54. Vazquez Moron S, Juste J, Ibanez C, Berciano J, Echevarria J. Phylogeny of European bat Lyssavirus 1 in Eptesicus isabellinus bats, Spain. Emerg Infect Dis. 2011;17:520-3 pubmed publisher
    ..An independent cluster of EBLV-1 possibly resulted from geographic isolation and association with a different reservoir from other European strains. EBLV-1 phylogeny is complex and probably associated with host evolutionary history...
  55. Wakeley P, Johnson N, McElhinney L, Marston D, Sawyer J, Fooks A. Development of a real-time, TaqMan reverse transcription-PCR assay for detection and differentiation of lyssavirus genotypes 1, 5, and 6. J Clin Microbiol. 2005;43:2786-92 pubmed
    ..We propose that within a geographically constrained area, this assay will be a useful tool for the detection and differentiation of members of the Lyssavirus genus...
  56. Allison A, Palacios G, Travassos da Rosa A, Popov V, Lu L, Xiao S, et al. Characterization of Durham virus, a novel rhabdovirus that encodes both a C and SH protein. Virus Res. 2011;155:112-22 pubmed publisher
  57. Purcell M, Garver K, Conway C, Elliott D, Kurath G. Infectious haematopoietic necrosis virus genogroup-specific virulence mechanisms in sockeye salmon, Oncorhynchus nerka (Walbaum), from Redfish Lake, Idaho. J Fish Dis. 2009;32:619-31 pubmed publisher
    ..We hypothesize that high virulence is associated with early in vivo replication allowing the virus to achieve a threshold level, which the host innate immune system cannot control...
  58. Li Y, Li C, Xue P, Zhong B, Mao A, Ran Y, et al. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A. 2009;106:7945-50 pubmed publisher
    ..These results suggest that ISG56 is a mediator of negative-feedback regulation of virus-triggered induction of type I IFNs and cellular antiviral responses...
  59. Hughes G, Kuzmin I, Schmitz A, Blanton J, Manangan J, Murphy S, et al. Experimental infection of big brown bats (Eptesicus fuscus) with Eurasian bat lyssaviruses Aravan, Khujand, and Irkut virus. Arch Virol. 2006;151:2021-35 pubmed
    ..The detection of viral RNA in oral swabs suggests that viral shedding in saliva occurred <5 days before the onset of clinical disease...
  60. Steel C, Hahto S, Ciavarra R. Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system. Virology. 2009;387:117-26 pubmed publisher
    ..Thus, both the inflammatory and certain components of the adaptive primary antiviral immune response in the CNS are dependent on peripheral DCs in vivo...
  61. Ciavarra R, Stephens A, Nagy S, Sekellick M, Steel C. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance?. J Immunol. 2006;177:492-500 pubmed
    ..Thus, sufficient redundancy exists in the immune system to sustain efficient viral clearance despite loss of an APC considered essential for induction of a primary antiviral immune response...
  62. Takumi K, Lina P, van der Poel W, Kramps J, van der Giessen J. Public health risk analysis of European bat lyssavirus infection in The Netherlands. Epidemiol Infect. 2009;137:803-9 pubmed publisher
    ..The risk of bat rabies is higher between April and October, and in the northern half of the country. This is the first study in Europe describing the risk of human bat rabies after bat contact incidents...
  63. Verjan N, Ooi E, Nochi T, Kondo H, Hirono I, Aoki T, et al. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008;25:170-80 pubmed publisher
    ..Thus a soluble nonglycosylated rIHNV-G protein could mediate the activation of rainbow trout leukocytes, with concomitant production of proinflammatory cytokines and IFNs...
  64. Marston D, Ellis R, Horton D, Kuzmin I, Wise E, McElhinney L, et al. Complete genome sequence of Ikoma lyssavirus. J Virol. 2012;86:10242-3 pubmed publisher
    ..Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection...
  65. Groocock G, Getchell R, Wooster G, Britt K, Batts W, Winton J, et al. Detection of viral hemorrhagic septicemia in round gobies in New York State (USA) waters of Lake Ontario and the St. Lawrence River. Dis Aquat Organ. 2007;76:187-92 pubmed
    ..The detection of VHSV in a relatively recent invasive fish species in the Great Lakes and the potential impact of VHSV on the ecology and economy of the area will require further investigation and careful management considerations...
  66. Choi M, Moon C, Ko M, Lee U, Cho W, Cha S, et al. A nuclear localization of the infectious haematopoietic necrosis virus NV protein is necessary for optimal viral growth. PLoS ONE. 2011;6:e22362 pubmed publisher
    ..These data suggest that the IHNV NV may support the growth of IHNV through inhibition of the INF system and the amino acid residues of (32)EGDL(35) responsible for nuclear localization are important for the inhibitory activity of NV...
  67. Freuling C, Beer M, Conraths F, Finke S, Hoffmann B, Keller B, et al. Novel lyssavirus in Natterer's bat, Germany. Emerg Infect Dis. 2011;17:1519-22 pubmed publisher
    ..Phylogenetic analysis supported the assumption that the isolated virus, Bokeloh bat lyssavirus, may represent a new member of the genus Lyssavirus...
  68. Kuzmin I, Niezgoda M, Franka R, Agwanda B, Markotter W, Beagley J, et al. Lagos bat virus in Kenya. J Clin Microbiol. 2008;46:1451-61 pubmed publisher
    ..Several large bat roosts were identified in areas of dense human populations, raising public health concerns for the potential of lyssavirus infection...
  69. Freuling C, Grossmann E, Conraths F, Schameitat A, Kliemt J, Auer E, et al. First isolation of EBLV-2 in Germany. Vet Microbiol. 2008;131:26-34 pubmed publisher
    ..Phylogenetic analysis indicated an association to EBLV-2 isolates from Switzerland which correlates with the origin of the bat close to the Swiss border...
  70. Markotter W, Kuzmin I, Rupprecht C, Nel L. Lagos bat virus virulence in mice inoculated by the peripheral route. Epidemiol Infect. 2009;137:1155-62 pubmed publisher
    ..Such molecular variability potentially contributes to differences in peripheral pathogenicity of lyssaviruses...
  71. Bangham J, Kim K, Webster C, Jiggins F. Genetic variation affecting host-parasite interactions: different genes affect different aspects of sigma virus replication and transmission in Drosophila melanogaster. Genetics. 2008;178:2191-9 pubmed publisher
    ..This suggests that different loci affect viral replication and paternal transmission...
  72. Al Hussinee L, Lord S, Stevenson R, Casey R, Groocock G, Britt K, et al. Immunohistochemistry and pathology of multiple Great Lakes fish from mortality events associated with viral hemorrhagic septicemia virus type IVb. Dis Aquat Organ. 2011;93:117-27 pubmed publisher
    ..By contrast, renal tubules and gonadal tissues (ovary and testis), were strongly immunopositive for VHSV IVb, but no lesions were noted...
  73. Hayman D, Fooks A, Horton D, Suu Ire R, Breed A, Cunningham A, et al. Antibodies against Lagos bat virus in megachiroptera from West Africa. Emerg Infect Dis. 2008;14:926-8 pubmed publisher
    ..Neutralizing antibodies were detected in Eidolon helvum (37%), Epomophorus gambianus (3%), and Epomops buettikoferi (33%, 2/6) from Ghana. These findings confirm the presence of LBV in West Africa...
  74. Vazquez Moron S, Juste J, Ibanez C, Ruiz Villamor E, Avellón A, Vera M, et al. Endemic circulation of European bat lyssavirus type 1 in serotine bats, Spain. Emerg Infect Dis. 2008;14:1263-6 pubmed publisher
    ..Viral genome and antibodies were detected in healthy bats, which suggests subclinical infection. The different temporal patterns of circulation found in each colony indicate independent endemic circulation...
  75. Kurath G, Garver K, LaPatra S, Purcell M. Resistance and protective immunity in Redfish Lake sockeye salmon exposed to M type infectious hematopoietic necrosis virus (IHNV). J Aquat Anim Health. 2010;22:129-39 pubmed publisher
  76. Purcell M, Nichols K, Winton J, Kurath G, Thorgaard G, Wheeler P, et al. Comprehensive gene expression profiling following DNA vaccination of rainbow trout against infectious hematopoietic necrosis virus. Mol Immunol. 2006;43:2089-106 pubmed
    ..The results presented here suggest that the IHNV DNA vaccine induces up-regulation of the type I IFN system across multiple tissues, which is the functional basis of early anti-viral immunity...
  77. López Muñoz A, Roca F, Sepulcre M, Meseguer J, Mulero V. Zebrafish larvae are unable to mount a protective antiviral response against waterborne infection by spring viremia of carp virus. Dev Comp Immunol. 2010;34:546-52 pubmed publisher
    ..This model, in combination with the powerful gene overexpression and morpholino-mediated knockdown techniques, will help to illuminate the IFN system of teleost fish...
  78. Kuzmin I, Mayer A, Niezgoda M, Markotter W, Agwanda B, Breiman R, et al. Shimoni bat virus, a new representative of the Lyssavirus genus. Virus Res. 2010;149:197-210 pubmed publisher
    ..However, the identity values alone are not considered sufficient criteria for demarcation of new species within LBV...
  79. Zhu R, Lei X, Ke F, Yuan X, Zhang Q. Genome of turbot rhabdovirus exhibits unusual non-coding regions and an additional ORF that could be expressed in fish cell. Virus Res. 2011;155:495-505 pubmed publisher
  80. Emmenegger E, Kurath G. DNA vaccine protects ornamental koi (Cyprinus carpio koi) against North American spring viremia of carp virus. Vaccine. 2008;26:6415-21 pubmed publisher
    ..These experiments prove that the SVCV DNA (pSGnc) vaccine can elicit specific reproducible protection and validates its potential use as a prophylactic vaccine in koi and other vulnerable North American fish stocks...