henipavirus infections


Summary: Infections with viruses of the genus HENIPAVIRUS, family PARAMYXOVIRIDAE.

Top Publications

  1. Fogarty R, Halpin K, Hyatt A, Daszak P, Mungall B. Henipavirus susceptibility to environmental variables. Virus Res. 2008;132:140-4 pubmed publisher
  2. Whitman S, Dutch R. Surface density of the Hendra G protein modulates Hendra F protein-promoted membrane fusion: role for Hendra G protein trafficking and degradation. Virology. 2007;363:419-29 pubmed
    ..Our results also showed that Hendra G protein levels are modulated by both more rapid protein turnover and slower protein trafficking than is seen for Hendra F. ..
  3. Dimitrov D, Wang L. In utero transmission of Nipah virus: role played by pregnancy and vertical transmission in Henipavirus epidemiology. J Infect Dis. 2007;196:807-9 pubmed
  4. Marsh G, Wang L. Hendra and Nipah viruses: why are they so deadly?. Curr Opin Virol. 2012;2:242-7 pubmed publisher
    ..Our recent study on the mechanism of IFN antagonism by henipaviruses indicated that a better understanding of the virus-host interaction provides great potential to develop new therapeutic strategies against these viruses. ..
  5. Mungall B, Schopman N, Lambeth L, Doran T. Inhibition of Henipavirus infection by RNA interference. Antiviral Res. 2008;80:324-31 pubmed publisher
    ..The demonstration that RNAi effectively inhibits henipavirus replication in vitro, is a novel approach and may provide an effective therapy for these highly lethal, zoonotic pathogens. ..
  6. Weingartl H, Berhane Y, Czub M. Animal models of henipavirus infection: a review. Vet J. 2009;181:211-20 pubmed publisher
    ..Susceptibility to infection and virus distribution in the individual species is discussed, along with the pathogenesis, pathological changes, and potential routes of transmission. ..
  7. Wong K, Robertson T, Ong B, Chong J, Yaiw K, Wang L, et al. Human Hendra virus infection causes acute and relapsing encephalitis. Neuropathol Appl Neurobiol. 2009;35:296-305 pubmed publisher
    ..Hendra virus can cause acute and relapsing encephalitis and the findings suggest that the pathology and pathogenesis are similar to Nipah virus infection. ..
  8. Field H, Mackenzie J, Daszak P. Henipaviruses: emerging paramyxoviruses associated with fruit bats. Curr Top Microbiol Immunol. 2007;315:133-59 pubmed
    ..Investigation of the emergence and ecology of henipaviruses warrants a broad, cross-disciplinary ecosystem health approach that recognises the critical linkages between human activity, ecological change, and livestock and human health. ..
  9. Breed A, Yu M, Barr J, Crameri G, Thalmann C, Wang L. Prevalence of henipavirus and rubulavirus antibodies in pteropid bats, Papua New Guinea. Emerg Infect Dis. 2010;16:1997-9 pubmed publisher
    ..Notably, 36% of bats surveyed contained antibodies to both types of viruses, indicating concurrent or consecutive infection...

More Information


  1. Playford E, McCall B, Smith G, Slinko V, Allen G, Smith I, et al. Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008. Emerg Infect Dis. 2010;16:219-23 pubmed publisher
    ..Emergence of Hendra virus is a serious medical, veterinary, and public health challenge. ..
  2. Halpin K, Hyatt A, Fogarty R, Middleton D, Bingham J, Epstein J, et al. Pteropid bats are confirmed as the reservoir hosts of henipaviruses: a comprehensive experimental study of virus transmission. Am J Trop Med Hyg. 2011;85:946-51 pubmed publisher
    ..An alternate assessment framework is required if we are to fully understand how this reservoir host maintains and transmits not only these but all viruses with which it has been associated...
  3. Bossart K, Geisbert T, Feldmann H, Zhu Z, Feldmann F, Geisbert J, et al. A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge. Sci Transl Med. 2011;3:105ra103 pubmed publisher
    ..These results represent successful post-exposure in vivo efficacy by an investigational drug against HeV and highlight the potential impact a hmAb can have on human disease. ..
  4. Pallister J, Middleton D, Wang L, Klein R, Haining J, Robinson R, et al. A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge. Vaccine. 2011;29:5623-30 pubmed publisher
    ..Together, our findings indicate that 100 ?g or 20 ?g doses of HeVsG vaccine can completely prevent a productive HeV infection in the ferret, suggesting that vaccination to prevent the infection and shedding of HeV is possible...
  5. Epstein J, Prakash V, Smith C, Daszak P, McLaughlin A, Meehan G, et al. Henipavirus infection in fruit bats (Pteropus giganteus), India. Emerg Infect Dis. 2008;14:1309-11 pubmed publisher
    ..Twenty bats were seropositive for Nipah virus, which suggests circulation in this species, thereby extending the known distribution of henipaviruses in Asia westward by >1,000 km. ..
  6. Ksiazek T, Rota P, Rollin P. A review of Nipah and Hendra viruses with an historical aside. Virus Res. 2011;162:173-83 pubmed publisher
    ..A historical aside summarizes the role that Dr. Brian W.J. Mahy played at critical junctures in the early stories of these viruses...
  7. Maar D, Harmon B, Chu D, Schulz B, Aguilar H, Lee B, et al. Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation. J Virol. 2012;86:6632-42 pubmed publisher
    ..Our data propose that the cysteine cluster in the NiV-G stalk functions to maintain oligomeric stability but is more importantly involved in stabilizing a unique microdomain critical for triggering fusion...
  8. Foord A, Middleton D, Heine H. Hendra virus detection using Loop-Mediated Isothermal Amplification. J Virol Methods. 2012;181:93-6 pubmed publisher
    ..The combined LAMP-LFD procedure is a sensitive method suitable for HeV diagnosis in a resource-limited situation or where rapid test results are critical. ..
  9. Nahar N, Sultana R, Gurley E, Hossain M, Luby S. Date palm sap collection: exploring opportunities to prevent Nipah transmission. Ecohealth. 2010;7:196-203 pubmed publisher
    ..Further studies to explore the effectiveness of these methods and to motivate gachhis to invest their time and money to use them could reduce the risk of human Nipah infection in Bangladesh. ..
  10. Marsh G, De Jong C, Barr J, Tachedjian M, Smith C, Middleton D, et al. Cedar virus: a novel Henipavirus isolated from Australian bats. PLoS Pathog. 2012;8:e1002836 pubmed publisher
    ..Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV. ..
  11. Bossart K, McEachern J, Hickey A, Choudhry V, Dimitrov D, Eaton B, et al. Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems. J Virol Methods. 2007;142:29-40 pubmed
    ..Sera from henipavirus-seropositive animals differentially blocked ephrin-B2 binding, suggesting that detection and differentiation of HeV and NiV neutralizing antibodies can be done simultaneously in the absence of live virus. ..
  12. Pulliam J, Field H, Olival K. Nipah virus strain variation. Emerg Infect Dis. 2005;11:1978-9; author reply 1979 pubmed
  13. Geisbert T, Daddario DiCaprio K, Hickey A, Smith M, Chan Y, Wang L, et al. Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection. PLoS ONE. 2010;5:e10690 pubmed publisher
  14. Field H, Schaaf K, Kung N, Simon C, Waltisbuhl D, Hobert H, et al. Hendra virus outbreak with novel clinical features, Australia. Emerg Infect Dis. 2010;16:338-40 pubmed publisher
    ..Four of 5 infected horses died, as did 1 of 2 infected staff members. Clinical manifestation in horses was predominantly neurologic. Preclinical transmission appears likely. ..
  15. Bossart K, Zhu Z, Middleton D, Klippel J, Crameri G, Bingham J, et al. A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection. PLoS Pathog. 2009;5:e1000642 pubmed publisher
    ..This study is the first successful post-exposure passive antibody therapy for Nipah virus using a human monoclonal antibody. ..
  16. Stachowiak B, Weingartl H. Nipah virus infects specific subsets of porcine peripheral blood mononuclear cells. PLoS ONE. 2012;7:e30855 pubmed publisher
  17. Marsh G, Todd S, Foord A, Hansson E, Davies K, Wright L, et al. Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia. Emerg Infect Dis. 2010;16:1767-9 pubmed publisher
    ..Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks. ..
  18. Xiao C, Liu Y, Jiang Y, Magoffin D, Guo H, Xuan H, et al. Monoclonal antibodies against the nucleocapsid proteins of henipaviruses: production, epitope mapping and application in immunohistochemistry. Arch Virol. 2008;153:273-81 pubmed
    ..These reagents will be a useful addition to the collection of tools essential for further research and improvement in diagnosis of henipaviruses. ..
  19. Sendow I, Field H, Adjid A, Ratnawati A, Breed A, Darminto -, et al. Screening for Nipah virus infection in West Kalimantan province, Indonesia. Zoonoses Public Health. 2010;57:499-503 pubmed publisher
    ..The survey found no evidence of exposure to Nipah virus in pigs. In contrast, 19% of the 84 Pteropus vampyrus bat sera reacted in the ELISA, but none of 15 Cynopterus brachyotis bats reacted. ..
  20. Butler D. Fatal fruit bat virus sparks epidemics in southern Asia. Nature. 2004;429:7 pubmed
  21. Sohayati A, Hassan L, Sharifah S, Lazarus K, Zaini C, Epstein J, et al. Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus. Epidemiol Infect. 2011;139:1570-9 pubmed publisher
    ..Based on the temporal cluster of seroconversion, we strongly believe that the NiV isolated was recrudesced and then transmitted horizontally between bats during the study period...
  22. Eaton B, Broder C, Middleton D, Wang L. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol. 2006;4:23-35 pubmed
  23. Marianneau P, Guillaume V, Wong T, Badmanathan M, Looi R, Murri S, et al. Experimental infection of squirrel monkeys with nipah virus. Emerg Infect Dis. 2010;16:507-10 pubmed publisher
    ..Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production. ..
  24. Halpin K, Mungall B. Recent progress in henipavirus research. Comp Immunol Microbiol Infect Dis. 2007;30:287-307 pubmed
    ..Discovered on the cusp of the molecular technology revolution, much progress has been made in understanding these new viruses. This review endeavours to capture the depth and breadth of these recent advances. ..
  25. Wacharapluesadee S, Boongird K, Wanghongsa S, Ratanasetyuth N, Supavonwong P, Saengsen D, et al. A longitudinal study of the prevalence of Nipah virus in Pteropus lylei bats in Thailand: evidence for seasonal preference in disease transmission. Vector Borne Zoonotic Dis. 2010;10:183-90 pubmed publisher
    ..Knowledge of seasonal preferences of Nipah virus shedding in P. lylei will help us to better understand the dynamics of Nipah virus transmission and have implications for disease management. ..
  26. Williamson M, Torres Velez F. Henipavirus: a review of laboratory animal pathology. Vet Pathol. 2010;47:871-80 pubmed publisher
    ..Ribavirin and 6-aza-uridine were able to delay but not prevent NiV-induced mortality in hamsters. Further research is needed to develop a model and therapy for late-onset henipavirus encephalitis. ..
  27. Ploquin A, Szecsi J, Mathieu C, Guillaume V, Barateau V, Ong K, et al. Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines. J Infect Dis. 2013;207:469-78 pubmed publisher
    ..This study presents a new efficient vaccination strategy against henipaviruses and opens novel perspectives on the use of AAV vectors as vaccines against emergent diseases. ..
  28. Vigant F, Lee B. Hendra and nipah infection: pathology, models and potential therapies. Infect Disord Drug Targets. 2011;11:315-36 pubmed
    ..There are currently no approved effective prophylactic or therapeutic treatments for henipavirus infections. Although ribavirin was empirically used and seemed beneficial during the biggest outbreak caused by one ..
  29. Marsh G, Haining J, Hancock T, Robinson R, Foord A, Barr J, et al. Experimental infection of horses with Hendra virus/Australia/horse/2008/Redlands. Emerg Infect Dis. 2011;17:2232-8 pubmed publisher
    ..Our data suggest that a critical factor for reducing HeV exposure risk to humans includes early consideration of HeV in the differential diagnosis and institution of appropriate infection control procedures...
  30. Mathieu C, Guillaume V, Sabine A, Ong K, Wong K, Legras Lachuer C, et al. Lethal Nipah virus infection induces rapid overexpression of CXCL10. PLoS ONE. 2012;7:e32157 pubmed publisher
    ..This study sheds new light on NiV pathogenesis, indicating the role of CXCL10 during the course of infection and suggests that this chemokine may serve as a potential new marker for lethal NiV encephalitis...
  31. McEachern J, Bingham J, Crameri G, Green D, Hancock T, Middleton D, et al. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine. 2008;26:3842-52 pubmed publisher
    ..The ability to elicit protective systemic and mucosal immunity in this animal model provides significant progress towards the development of a human subunit vaccine against henipaviruses. ..
  32. Wong K, Grosjean I, Brisson C, Blanquier B, Fevre Montange M, Bernard A, et al. A golden hamster model for human acute Nipah virus infection. Am J Pathol. 2003;163:2127-37 pubmed
    ..The golden hamster is proposed as a suitable model for further studies including pathogenesis studies, anti-viral drug testing, and vaccine development against acute Nipah infection...
  33. Lim C, Lee W, Leo Y, Lee K, Chan K, Ling A, et al. Late clinical and magnetic resonance imaging follow up of Nipah virus infection. J Neurol Neurosurg Psychiatry. 2003;74:131-3 pubmed
    ..These findings suggest that in addition to encephalitis, the newly discovered Nipah virus affects the spinal cord and the retina. Late clinical and radiological findings can occur in Nipah virus infections as with other paramyxoviruses...
  34. Enserink M. Emerging infectious diseases. Nipah virus (or a cousin) strikes again. Science. 2004;303:1121 pubmed
  35. Epstein J, Abdul Rahman S, Zambriski J, Halpin K, Meehan G, Jamaluddin A, et al. Feral cats and risk for Nipah virus transmission. Emerg Infect Dis. 2006;12:1178-9 pubmed
  36. Hossain M, Gurley E, Montgomery J, Bell M, Carroll D, Hsu V, et al. Clinical presentation of nipah virus infection in Bangladesh. Clin Infect Dis. 2008;46:977-84 pubmed publisher
    ..In Bangladesh, 4 outbreaks of Nipah virus infection were identified during the period 2001-2004...
  37. Rockx B, Brining D, Kramer J, Callison J, Ebihara H, Mansfield K, et al. Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection. J Virol. 2011;85:7658-71 pubmed publisher
  38. Guillaume V, Contamin H, Loth P, Grosjean I, Courbot M, Deubel V, et al. Antibody prophylaxis and therapy against Nipah virus infection in hamsters. J Virol. 2006;80:1972-8 pubmed
    ..Our studies suggest that immunotherapy could be used for people who are exposed to NiV infections...
  39. Wong K. Emerging epidemic viral encephalitides with a special focus on henipaviruses. Acta Neuropathol. 2010;120:317-25 pubmed publisher
    ..Future emerging viral encephalitides will no doubt continue to pose considerable challenges to the neuropathologist, and as the West Nile virus outbreak demonstrates, even economically advanced nations are not spared...
  40. Wacharapluesadee S, Lumlertdacha B, Boongird K, Wanghongsa S, Chanhome L, Rollin P, et al. Bat Nipah virus, Thailand. Emerg Infect Dis. 2005;11:1949-51 pubmed
    ..Immunoglobulin G antibodies to NV were detected with enzyme immunoassay in 82 of 1,304 bats. NV RNA was found in bat saliva and urine. These data suggest the persistence of NV infection in Thai bats...
  41. Juozapaitis M, Serva A, Zvirbliene A, Slibinskas R, Staniulis J, Sasnauskas K, et al. Generation of henipavirus nucleocapsid proteins in yeast Saccharomyces cerevisiae. Virus Res. 2007;124:95-102 pubmed
    ..The development of an efficient and cost-effective system for generation of henipavirus nucleocapsid proteins might help to improve reagents for diagnosis of viruses...
  42. Pallister J, Middleton D, Crameri G, Yamada M, Klein R, Hancock T, et al. Chloroquine administration does not prevent Nipah virus infection and disease in ferrets. J Virol. 2009;83:11979-82 pubmed publisher
    ..Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo...
  43. Lee B. Envelope-receptor interactions in Nipah virus pathobiology. Ann N Y Acad Sci. 2007;1102:51-65 pubmed
  44. Sejvar J, Hossain J, Saha S, Gurley E, Banu S, Hamadani J, et al. Long-term neurological and functional outcome in Nipah virus infection. Ann Neurol. 2007;62:235-42 pubmed
    ..Long-term neurological assessments of survivors are limited. We assessed long-term neurologic and functional outcomes of 22 patients surviving NiV illness in Bangladesh...
  45. Gurley E, Montgomery J, Hossain M, Bell M, Azad A, Islam M, et al. Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerg Infect Dis. 2007;13:1031-7 pubmed publisher
    ..Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings...
  46. Field H, Kung N. Henipaviruses-unanswered questions of lethal zoonoses. Curr Opin Virol. 2011;1:658-61 pubmed publisher
    ..In this paper, we pose and probe these questions in context, and offer perspectives based primarily on our experience with Hendra virus in Australia, augmented with Nipah virus parallels...
  47. Chattopadhyay A, Rose J. Complementing defective viruses that express separate paramyxovirus glycoproteins provide a new vaccine vector approach. J Virol. 2011;85:2004-11 pubmed publisher
    ..Such an approach minimizes biosafety concerns that could apply to single, replication-competent VSV recombinants expressing all proteins required for infection...
  48. Middleton D, Morrissy C, van der Heide B, Russell G, Braun M, Westbury H, et al. Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus). J Comp Pathol. 2007;136:266-72 pubmed
  49. Lo M, Lowe L, Hummel K, Sazzad H, Gurley E, Hossain M, et al. Characterization of Nipah virus from outbreaks in Bangladesh, 2008-2010. Emerg Infect Dis. 2012;18:248-55 pubmed publisher
    ..Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences...
  50. Homaira N, Rahman M, Hossain M, Nahar N, Khan R, Rahman M, et al. Cluster of Nipah virus infection, Kushtia District, Bangladesh, 2007. PLoS ONE. 2010;5:e13570 pubmed publisher
    ..In March 2007, we investigated a cluster of Nipah encephalitis to identify risk factors for Nipah infection in Bangladesh...
  51. Harit A, Ichhpujani R, Gupta S, Gill K, Lal S, Ganguly N, et al. Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001. Indian J Med Res. 2006;123:553-60 pubmed
    ..This outbreak was investigated by a team of scientists from four major institutions, and the findings are presented here...
  52. Hsu V, Hossain M, Parashar U, Ali M, Ksiazek T, Kuzmin I, et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis. 2004;10:2082-7 pubmed
    ..Surveillance and enhancement of diagnostic capacity to detect Nipah virus infection are recommended...
  53. Rockx B, Bossart K, Feldmann F, Geisbert J, Hickey A, Brining D, et al. A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment. J Virol. 2010;84:9831-9 pubmed publisher
  54. Weingartl H, Czub S, Copps J, Berhane Y, Middleton D, Marszal P, et al. Invasion of the central nervous system in a porcine host by nipah virus. J Virol. 2005;79:7528-34 pubmed
  55. Arankalle V, Bandyopadhyay B, Ramdasi A, Jadi R, Patil D, Rahman M, et al. Genomic characterization of Nipah virus, West Bengal, India. Emerg Infect Dis. 2011;17:907-9 pubmed publisher
    ..Full-genome sequence of Nipah virus (18,252 nt) amplified from lung tissue showed 99.2% nt and 99.8% aa identity with the Bangladesh-2004 isolate, suggesting a common source of the virus...
  56. Mahalingam S, Herrero L, Playford E, Spann K, Herring B, Rolph M, et al. Hendra virus: an emerging paramyxovirus in Australia. Lancet Infect Dis. 2012;12:799-807 pubmed publisher
  57. Chua K, Wong E, Cropp B, Hyatt A. Role of electron microscopy in Nipah virus outbreak investigation and control. Med J Malaysia. 2007;62:139-42 pubmed
  58. Hanna J, McBride W, Brookes D, Shield J, Taylor C, Smith I, et al. Hendra virus infection in a veterinarian. Med J Aust. 2006;185:562-4 pubmed
    ..Nevertheless, she remains well 2 years after her initial illness. Recently emerged zoonotic viruses, such as HeV, necessitate appropriate working procedures and personal protective equipment in veterinary practice...
  59. Luby S, Gurley E, Hossain M. Transmission of human infection with Nipah virus. Clin Infect Dis. 2009;49:1743-8 pubmed publisher
    ..Efforts to prevent transmission should focus on decreasing bat access to date palm sap and reducing family members' and friends' exposure to infected patients' saliva...
  60. AbuBakar S, Chang L, Ali A, Sharifah S, Yusoff K, Zamrod Z. Isolation and molecular identification of Nipah virus from pigs. Emerg Infect Dis. 2004;10:2228-30 pubmed
    ..At least two different Nipah virus strains, including a previously unreported strain, were identified. The findings highlight the possibility that the Malaysia outbreaks had two origins of Nipah virus infections...
  61. Berhane Y, Weingartl H, Lopez J, Neufeld J, Czub S, Embury Hyatt C, et al. Bacterial infections in pigs experimentally infected with Nipah virus. Transbound Emerg Dis. 2008;55:165-74 pubmed publisher
  62. Luby S, Hossain M, Gurley E, Ahmed B, Banu S, Khan S, et al. Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. Emerg Infect Dis. 2009;15:1229-35 pubmed publisher
    ..Interventions to prevent virus transmission from bats to humans and from person to person are needed...
  63. Berhane Y, Berry J, Ranadheera C, Marszal P, Nicolas B, Yuan X, et al. Production and characterization of monoclonal antibodies against binary ethylenimine inactivated Nipah virus. J Virol Methods. 2006;132:59-68 pubmed
    ..Two of the mAbs were specific for the Nipah virus only, F45G4 (anti-N) and F45G5 (anti-M), and could be used in the primary identification of Nipah virus. The use of these immunoreagents to develop new diagnostic assays is discussed...
  64. Broder C. Henipavirus outbreaks to antivirals: the current status of potential therapeutics. Curr Opin Virol. 2012;2:176-87 pubmed publisher
    ..Here, recent findings on the few most advanced henipavirus countermeasures are summarized and discussed...
  65. Sendow I, Field H, Curran J, Darminto -, Morrissy C, Meehan G, et al. Henipavirus in Pteropus vampyrus bats, Indonesia. Emerg Infect Dis. 2006;12:711-2 pubmed
  66. Homaira N, Rahman M, Hossain M, Epstein J, Sultana R, Khan M, et al. Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007. Epidemiol Infect. 2010;138:1630-6 pubmed publisher
    ..The outbreak was spread by person-to-person transmission. Risk of NiV infection in family caregivers highlights the need for infection control practices to limit transmission of potentially infectious body secretions...
  67. Tamin A, Harcourt B, Lo M, Roth J, Wolf M, Lee B, et al. Development of a neutralization assay for Nipah virus using pseudotype particles. J Virol Methods. 2009;160:1-6 pubmed publisher
    ..Therefore, this new method has the potential to be a rapid and cost-effective diagnostic method, especially in locations that lack high containment facilities, and will provide a valuable tool for basic research and vaccine development...
  68. Marsh G, Virtue E, Smith I, Todd S, Arkinstall R, Frazer L, et al. Recombinant Hendra viruses expressing a reporter gene retain pathogenicity in ferrets. Virol J. 2013;10:95 pubmed publisher
    ..Hendra virus (HeV) is an Australian bat-borne zoonotic paramyxovirus that repeatedly spills-over to horses causing fatal disease. Human cases have all been associated with close contact with infected horses...
  69. Aguilar H, Iorio R. Henipavirus membrane fusion and viral entry. Curr Top Microbiol Immunol. 2012;359:79-94 pubmed publisher
    ..Membrane fusion is essential to both viral entry and virus-induced cell-cell fusion, a hallmark of henipavirus infections. Elucidiation of the mechanism(s) of membrane fusion is critical to understanding henipavirus pathobiology ..
  70. Mendez D, Buttner P, Speare R. Response of Australian veterinarians to the announcement of a Hendra virus vaccine becoming available. Aust Vet J. 2013;91:328-31 pubmed publisher
    ..A cross-sectional study of private veterinarians providing equine services in Queensland...
  71. Mungall B, Middleton D, Crameri G, Bingham J, Halpin K, Russell G, et al. Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. J Virol. 2006;80:12293-302 pubmed
    ..These results indicate that the cat provides a consistent model for acute NiV infection and associated pathogenesis and an effective subunit vaccine strategy appears achievable...
  72. Guillaume V, Contamin H, Loth P, Georges Courbot M, Lefeuvre A, Marianneau P, et al. Nipah virus: vaccination and passive protection studies in a hamster model. J Virol. 2004;78:834-40 pubmed
  73. Blum L, Khan R, Nahar N, Breiman R. In-depth assessment of an outbreak of Nipah encephalitis with person-to-person transmission in Bangladesh: implications for prevention and control strategies. Am J Trop Med Hyg. 2009;80:96-102 pubmed
    ..Differing popular and medical views of illness caused conflict and rejection of biomedical recommendations. Future investigators should consider local perceptions of disease and treatment when developing outbreak strategies...
  74. Mills J, Alim A, Bunning M, Lee O, Wagoner K, Amman B, et al. Nipah virus infection in dogs, Malaysia, 1999. Emerg Infect Dis. 2009;15:950-2 pubmed publisher
    ..Serologic screening showed that, in the absence of infected pigs, dogs were not a secondary reservoir for Nipah virus...
  75. Luby S, Rahman M, Hossain M, Blum L, Husain M, Gurley E, et al. Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis. 2006;12:1888-94 pubmed
    ..This investigation suggests that Nipah virus was transmitted from P. giganteus to persons through drinking fresh date palm sap...
  76. Bossart K, Rockx B, Feldmann F, Brining D, Scott D, LaCasse R, et al. A Hendra virus G glycoprotein subunit vaccine protects African green monkeys from Nipah virus challenge. Sci Transl Med. 2012;4:146ra107 pubmed publisher
    ..Success of the recombinant subunit vaccine in nonhuman primates provides crucial data in supporting its further preclinical development for potential human use...
  77. Harcourt B, Lowe L, Tamin A, Liu X, Bankamp B, Bowden N, et al. Genetic characterization of Nipah virus, Bangladesh, 2004. Emerg Infect Dis. 2005;11:1594-7 pubmed
    ..We describe the genetic characterization of a new strain of NV isolated during outbreaks in Bangladesh (NV-B) in 2004, which confirms that NV was the etiologic agent responsible for these outbreaks...
  78. Lo M, Peeples M, Bellini W, Nichol S, Rota P, Spiropoulou C. Distinct and overlapping roles of Nipah virus P gene products in modulating the human endothelial cell antiviral response. PLoS ONE. 2012;7:e47790 pubmed publisher
    ..The results of this study also provide an opportunity to verify the results of earlier artificial plasmid expression studies in the context of authentic viral infection...
  79. Bellini W, Harcourt B, Bowden N, Rota P. Nipah virus: an emergent paramyxovirus causing severe encephalitis in humans. J Neurovirol. 2005;11:481-7 pubmed
    ..This review summarizes what is known about the virology, epidemiology, pathology, diagnosis and control of this novel pathogen...
  80. Porotto M, Orefice G, Yokoyama C, Mungall B, Realubit R, Sganga M, et al. Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol. 2009;83:5148-55 pubmed publisher
    ..Given the established safety profile and broad experience with chloroquine in humans, the results described here provide an option for treating individuals infected by these deadly viruses...
  81. Ciancanelli M, Volchkova V, Shaw M, Volchkov V, Basler C. Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism. J Virol. 2009;83:7828-41 pubmed publisher
    ..These data demonstrate that the gene for NiV P encodes functions that sequester inactive STAT1 in the nucleus, preventing its activation and suggest that the W protein is the dominant inhibitor of STAT1 in NiV-infected cells...
  82. Zhu Z, Bossart K, Bishop K, Crameri G, Dimitrov A, McEachern J, et al. Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody. J Infect Dis. 2008;197:846-53 pubmed publisher
    ..These results suggest that m102.4 has potential as a therapeutic agent for the treatment of diseases caused by henipaviruses. It could be also used for prophylaxis and diagnosis, and as a research reagent...
  83. Plowright R, Field H, Smith C, Divljan A, Palmer C, Tabor G, et al. Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus). Proc Biol Sci. 2008;275:861-9 pubmed publisher
    ..These insights into the ecology of HeV in flying fox populations suggest causal links between anthropogenic environmental change and HeV emergence...
  84. Rahman M, Hossain M, Sultana S, Homaira N, Khan S, Rahman M, et al. Date palm sap linked to Nipah virus outbreak in Bangladesh, 2008. Vector Borne Zoonotic Dis. 2012;12:65-72 pubmed publisher
    ..We investigated a cluster of patients with encephalitis in the Manikgonj and Rajbari Districts of Bangladesh in February 2008 to determine the etiology and risk factors for disease...
  85. Luby S, Gurley E. Epidemiology of henipavirus disease in humans. Curr Top Microbiol Immunol. 2012;359:25-40 pubmed publisher
    ..Although henipaviruses are not easily transmitted to people, these newly recognized, high mortality agents warrant continued scientific attention...
  86. Aguilar H, Matreyek K, Filone C, Hashimi S, Levroney E, Negrete O, et al. N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. J Virol. 2006;80:4878-89 pubmed
    ..These features underscore the varied roles that N-glycans on NiV-F play in the pathobiology of NiV entry but also shed light on the general mechanisms of paramyxovirus fusion with host cells...
  87. Levroney E, Aguilar H, Fulcher J, Kohatsu L, Pace K, Pang M, et al. Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines. J Immunol. 2005;175:413-20 pubmed
    ..Thus, gal-1 may have direct antiviral effects and may also augment the innate immune response against this emerging pathogen...
  88. Dups J, Middleton D, Yamada M, Monaghan P, Long F, Robinson R, et al. A new model for Hendra virus encephalitis in the mouse. PLoS ONE. 2012;7:e40308 pubmed publisher