borna disease

Summary

Summary: An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.

Top Publications

  1. Kinnunen P, Palva A, Vaheri A, Vapalahti O. Epidemiology and host spectrum of Borna disease virus infections. J Gen Virol. 2013;94:247-62 pubmed publisher
    b>Borna disease virus (BDV) has gained lot of interest because of its zoonotic potential, ability to introduce cDNA of its RNA transcripts into host genomes, and ability to cause severe neurobehavioural diseases...
  2. Hausmann J, Schamel K, Staeheli P. CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin. J Virol. 2001;75:10460-6 pubmed
    ..perforin in a mouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus...
  3. Matsunaga H, Tanaka S, Fukumori A, Tomonaga K, Ikuta K, Amino N, et al. Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population. J Clin Virol. 2008;43:317-22 pubmed publisher
    b>Borna disease virus (BDV) infection of humans has not been widely accepted due to the low titer of the antibody and lack of reliable diagnostic tools...
  4. Bacher M, Weihe E, Dietzschold B, Meinhardt A, Vedder H, Gemsa D, et al. Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration. Glia. 2002;37:291-306 pubmed
    ..invasion during virus-induced encephalitis, we analyzed the expression and cellular localization of MIF in the Borna disease virus (BDV)-infected rat brain, monitored monocyte/macrophage infiltration, and evaluated the influence of ..
  5. Pletnikov M, Rubin S, Schwartz G, Moran T, Sobotka T, Carbone K. Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. Physiol Behav. 1999;66:823-31 pubmed
    Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum...
  6. Schwemmle M. Borna disease virus infection in psychiatric patients: are we on the right track?. Lancet Infect Dis. 2001;1:46-52 pubmed
    Animals infected with Borna disease virus (BDV) typically present with neurological dysfunction including behavioural abnormalities...
  7. Billich C, Sauder C, Frank R, Herzog S, Bechter K, Takahashi K, et al. High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins. Biol Psychiatry. 2002;51:979-87 pubmed
    The recent observation that Borna disease virus (BDV)-reactive antibodies from psychiatric patients exhibit only low avidity for BDV antigen called into question their diagnostic value and raised the possibility that antigenically ..
  8. Durrwald R, Kolodziejek J, Herzog S, Nowotny N. Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness. Rev Med Virol. 2007;17:181-203 pubmed
    All Borna disease virus (BDV) sequences derived from human specimens published till date were thoroughly analysed and compared to sequences of BDV laboratory strains and to BDV sequences from animals which succumbed to classical Borna ..
  9. Hofer M, Hausmann J, Staeheli P, Pagenstecher A. Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice. Am J Pathol. 2004;165:949-58 pubmed
    ..Infection with noncytolytic Borna disease virus (BDV) did not affect wild-type mice but accelerated disease of IL-12 transgenic mice...

More Information

Publications92

  1. Henkel M, Planz O, Fischer T, Stitz L, Rziha H. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. J Virol. 2005;79:314-25 pubmed
    ..Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and ..
  2. Schneider U, Martin A, Schwemmle M, Staeheli P. Genome trimming by Borna disease viruses: viral replication control or escape from cellular surveillance?. Cell Mol Life Sci. 2007;64:1038-42 pubmed
    ..b>Borna disease virus (BDV), a negative strand RNA virus with no recognizable acute phase, quickly establishes persistence...
  3. Hausmann J, Baur K, Engelhardt K, Fischer T, Rziha H, Staeheli P. Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice. J Gen Virol. 2005;86:399-403 pubmed
    b>Borna disease virus (BDV) can persistently infect the central nervous system and induce CD8+ T-cell-mediated neurological disease in MRL mice...
  4. Carbone K, Rubin S, Nishino Y, Pletnikov M. Borna disease: virus-induced neurobehavioral disease pathogenesis. Curr Opin Microbiol. 2001;4:467-75 pubmed
    Studies of the pathogenesis of neurobehavioral diseases following Borna disease virus infections have been increasing rapidly over the past ten years...
  5. Lancaster K, Dietz D, Moran T, Pletnikov M. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav Brain Res. 2007;176:141-8 pubmed
    ..In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats...
  6. Ovanesov M, Vogel M, Moran T, Pletnikov M. Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum. J Neurovirol. 2007;13:185-94 pubmed
    The authors evaluated a role of glutamate (GLU) excitotoxicity in neonatal Borna disease virus (BDV) infection-associated neuronal injury by measuring extracellular levels of GLU in the striatum of 70-day-old Fischer344 rats using in ..
  7. Kamhieh S, Hodgson J, Bode L, Ludwig H, Ward C, Flower R. No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents. Arch Virol. 2006;151:709-19 pubmed
    b>Borna disease virus (BDV) is a unique RNA virus that is a cause of neurological disease in horses, sheep and cats. The finding that BDV also infects humans has raised concern related to the impact of infection with this virus...
  8. Pletnikov M, Rubin S, Vasudevan K, Moran T, Carbone K. Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism. Behav Brain Res. 1999;100:43-50 pubmed
    ..were observed in male juvenile Lewis rats with brain developmental injury following neonatal infection with Borna disease virus (BDV)...
  9. Schindler A, Vögtlin A, Hilbe M, Puorger M, Zlinszky K, Ackermann M, et al. Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts. Mol Cell Probes. 2007;21:47-55 pubmed
    b>Borna disease is a severe, immunopathological disorder of the central nervous system caused by the infection with the Borna disease virus (BDV)...
  10. Lieb K, Staeheli P. Borna disease virus--does it infect humans and cause psychiatric disorders?. J Clin Virol. 2001;21:119-27 pubmed
    Antibodies recognizing Borna disease virus (BDV) antigens were first demonstrated in the blood of psychiatric patients approximately 15 years ago...
  11. Stitz L, Nöske K, Planz O, Furrer E, Lipkin W, Bilzer T. A functional role for neutralizing antibodies in Borna disease: influence on virus tropism outside the central nervous system. J Virol. 1998;72:8884-92 pubmed
    b>Borna disease virus (BDV) is a negative-strand RNA virus that infects the central nervous systems (CNS) of warm-blooded animals and causes disturbances of movement and behavior...
  12. de la Torre J. Bornavirus and the brain. J Infect Dis. 2002;186 Suppl 2:S241-7 pubmed
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus...
  13. Volmer R, Prat C, Le Masson G, Garenne A, Gonzalez Dunia D. Borna disease virus infection impairs synaptic plasticity. J Virol. 2007;81:8833-7 pubmed
    The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood...
  14. Furrer E, Bilzer T, Stitz L, Planz O. High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology. J Virol. 2001;75:11700-8 pubmed
    Experimental Borna disease virus (BDV) infection of rats and natural infection of horses and sheep leads to severe central nervous system disease based on immunopathological pathways...
  15. Rauer M, Götz J, Schuppli D, Staeheli P, Hausmann J. Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease. J Virol. 2004;78:3621-32 pubmed
    The nucleoprotein (N) of Borna disease virus (BDV) is the major target of the disease-inducing antiviral CD8 T-cell response in the central nervous system of mice...
  16. Hans A, Syan S, Crosio C, Sassone Corsi P, Brahic M, Gonzalez Dunia D. Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells. J Biol Chem. 2001;276:7258-65 pubmed
    Persistence of Borna disease virus (BDV) in the central nervous system causes damage to specific neuronal populations. BDV is noncytopathic, and the mechanisms underlying neuronal pathology are not well understood...
  17. Hagiwara K, Kamitani W, Takamura S, Taniyama H, Nakaya T, Tanaka H, et al. Detection of Borna disease virus in a pregnant mare and her fetus. Vet Microbiol. 2000;72:207-16 pubmed
    ..mare showing pyrexia, reduced appetite, ataxia and paresis was euthanized and examined for the presence of Borna disease virus (BDV)...
  18. Ouchi A, Kishi M, Kobayashi T, Lai P, Malik T, Ikuta K, et al. Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia. J Vet Med Sci. 2001;63:1279-85 pubmed
    Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46...
  19. Herden C, Schluesener H, Richt J. Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. Neuropathol Appl Neurobiol. 2005;31:512-21 pubmed
    Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis...
  20. Rauer M, Pagenstecher A, Schulte Mönting J, Sauder C. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. J Neurovirol. 2002;8:168-79 pubmed
    Infection of adult rats with Borna disease virus (BDV) causes CD8 T cell-mediated meningoencephalitis. Previously, we described a complex pattern of chemokine gene expression in the central nervous system (CNS) of such rats...
  21. Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, et al. Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci U S A. 2005;102:13640-5 pubmed
    ..b>Borna disease virus (BDV) establishes persistent noncytolytic infections in animals and tissue culture cells, indicating ..
  22. Rybakowski F, Yamaguchi K, Krzymiński S, Zmyślony F, Biernat J, Kociałkowski M, et al. [Detection of anti-Borna disease virus antibodies in patients hospitalized in psychiatric hospitals located in the mid-Western region of Poland]. Psychiatr Pol. 2001;35:819-29 pubmed
    b>Borna Disease Virus (BDV) is single stranded RNA virus, which may infect a wide range of animal species. Manifestations of the experimental BDV infection show some resemblance to psychopathological symptoms of mental disorders in humans...
  23. Davidson F, Lycett C, Petrik J, Fazakerley J. Investigation of frequency of active Borna disease virus infection in Scottish blood donors. Vox Sang. 2004;86:148-50 pubmed
    b>Borna disease virus (BDV) can infect a wide range of vertebrate species causing neurological disease. In order to ensure the safety of blood supplies, it is essential to monitor blood for emerging pathogens.
  24. Stitz L, Bilzer T, Planz O. The immunopathogenesis of Borna disease virus infection. Front Biosci. 2002;7:d541-55 pubmed
    b>Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system...
  25. Pannicke T, Weick M, Uckermann O, Wheeler Schilling T, Fries J, Reichel M, et al. Electrophysiological alterations and upregulation of ATP receptors in retinal glial Müller cells from rats infected with the Borna disease virus. Glia. 2001;35:213-23 pubmed
    Infection with the neurotropic Borna disease virus (BDV) causes an immune-mediated neurological disease in a broad range of species...
  26. Jacobsen B, Algermissen D, Schaudien D, Venner M, Herzog S, Wentz E, et al. Borna disease in an adult alpaca stallion (Lama pacos). J Comp Pathol. 2010;143:203-8 pubmed publisher
    b>Borna disease (BD) was diagnosed in a 2-year-old male alpaca with a history of chronic suppressed sexual desire and acute stretching convulsions...
  27. Sauder C, Staeheli P. Rat model of borna disease virus transmission: epidemiological implications. J Virol. 2003;77:12886-90 pubmed
    Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats...
  28. Durrwald R, Kolodziejek J, Muluneh A, Herzog S, Nowotny N. Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations. Microbes Infect. 2006;8:917-29 pubmed
    Classical Borna disease (cBD), a non-purulent encephalitis of solipeds and sheep, is endemic in certain areas of central Europe. The etiologic agent is Borna disease virus (BDV), thus far the only member of the family Bornaviridae...
  29. Jehle C, Herpfer I, Rauer M, Schwemmle M, Sauder C. Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. Arch Virol. 2003;148:45-63 pubmed
    Infection of newborn rats with Borna disease virus (BDV) leads to viral persistence in the central nervous system without overt signs of inflammation...
  30. Yamaguchi K, Sawada T, Naraki T, Igata Yi R, Shiraki H, Horii Y, et al. Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. Clin Diagn Lab Immunol. 1999;6:696-700 pubmed
    The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods...
  31. Poenisch M, Staeheli P, Schneider U. Viral accessory protein X stimulates the assembly of functional Borna disease virus polymerase complexes. J Gen Virol. 2008;89:1442-5 pubmed publisher
    The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA...
  32. Pletnikov M, Rubin S, Schwartz G, Carbone K, Moran T. Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems. Brain Res Dev Brain Res. 2000;119:179-85 pubmed
    Effects of neonatal Borna disease virus infection (BDV) on the postnatal development of brain monoaminergic systems in rats were studied...
  33. Weissenbock H, Nowotny N, Caplazi P, Kolodziejek J, Ehrensperger F. Borna disease in a dog with lethal meningoencephalitis. J Clin Microbiol. 1998;36:2127-30 pubmed
    ..By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog...
  34. Hausmann J, Pagenstecher A, Baur K, Richter K, Rziha H, Staeheli P. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol. 2005;79:13509-18 pubmed
    b>Borna disease virus (BDV) frequently causes meningoencephalitis and fatal neurological disease in young but not old mice of strain MRL. Disease does not result from the virus-induced destruction of infected neurons...
  35. Poenisch M, Burger N, Staeheli P, Bauer G, Schneider U. Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. J Virol. 2009;83:4297-307 pubmed publisher
    b>Borna disease virus (BDV) is a neurotropic member of the order Mononegavirales with noncytolytic replication and obligatory persistence in cultured cells and animals...
  36. Kinnunen P, Inkeroinen H, Ilander M, Kallio E, Heikkilä H, Koskela E, et al. Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA. PLoS ONE. 2011;6:e23622 pubmed publisher
    ..The epidemiology of Borna disease virus (BDV), as for other members of the family Bornaviridae, is largely unknown, although evidence exists for ..
  37. Huang R, Gao H, Zhang L, Jia J, Liu X, Zheng P, et al. Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. PLoS ONE. 2012;7:e44665 pubmed publisher
    b>Borna disease virus is a neurotropic, non-cytolytic virus that has been widely employed in neuroscientific research. Previous studies have revealed that metabolic perturbations are associated with Borna disease viral infection...
  38. Dittrich W, Bode L, Ludwig H, Kao M, Schneider K. Learning deficiencies in Borna disease virus-infected but clinically healthy rats. Biol Psychiatry. 1989;26:818-28 pubmed
    b>Borna disease (BD) virus, a still unclassified neurotropic agent, causes either fatal encephalomyelitis or persistent asymptomatic infection in a variety of animal species...
  39. Helps C, Turan N, Bilal T, Harbour D, Yilmaz H. Detection of antibodies to Borna disease virus in Turkish cats by using recombinant p40. Vet Rec. 2001;149:647-50 pubmed
    ..Antibodies to Borna disease virus- (BDV) p40 were detected in 34 (42-5 per cent) of the 80 cats...
  40. Hornig M, Solbrig M, Horscroft N, Weissenbock H, Lipkin W. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease. Curr Top Microbiol Immunol. 2001;253:157-77 pubmed
    ..Two models have been established based on Borna disease virus infection that provide new insights into mechanisms by which neurotropic agents and/or immune factors ..
  41. Allmang U, Hofer M, Herzog S, Bechter K, Staeheli P. Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Mol Psychiatry. 2001;6:329-33 pubmed
    b>Borna disease virus (BDV) can induce neurological disease in animals...
  42. Prat C, Schmid S, Farrugia F, Cenac N, Le Masson G, Schwemmle M, et al. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. PLoS Pathog. 2009;5:e1000425 pubmed publisher
    ..b>Borna disease virus (BDV) represents an attractive model system to analyze the molecular mechanisms whereby a virus can ..
  43. Vahlenkamp T, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. J Virol. 2002;76:9735-43 pubmed
    To get an insight into Borna disease virus (BDV) epidemiology, an isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period...
  44. Gonzalez Dunia D, Volmer R, Mayer D, Schwemmle M. Borna disease virus interference with neuronal plasticity. Virus Res. 2005;111:224-34 pubmed
    ..The mechanisms whereby such infections disturb brain functions are beginning to emerge. Borna disease virus (BDV), which causes a persistent infection of neurons without direct cytolysis in several mammalian ..
  45. Lebain P, Vabret A, Freymuth F, Brazo P, Chabot B, Dollfus S, et al. Borna disease virus and psychiatric disorders. Schizophr Res. 2002;57:303-5 pubmed
  46. Solbrig M, Koob G. Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus. Pharmacol Biochem Behav. 2003;74:777-87 pubmed
    b>Borna Disease Virus (BDV) is a neurotropic RNA virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species...
  47. Caplazi P, Melzer K, Goetzmann R, Rohner Cotti A, Bracher V, Zlinszky K, et al. [Borna disease in Switzerland and in the principality of Liechtenstein]. Schweiz Arch Tierheilkd. 1999;141:521-7 pubmed
    b>Borna disease (BD) is a rare immunopathological disorder of the central nervous system (CNS) caused by infection with Borna disease virus (BDV) and histologically characterized by mononuclear encephalomyelitis...
  48. de La Torre J, Bode L, Durrwald R, Cubitt B, Ludwig H. Sequence characterization of human Borna disease virus. Virus Res. 1996;44:33-44 pubmed
    b>Borna disease virus (BDV) causes a central nervous system disease in several vertebrate animal species, which is manifest by behavioral abnormalities...
  49. Ovanesov M, Moldovan K, Smith K, Vogel M, Pletnikov M. Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus. J Neuroinflammation. 2008;5:16 pubmed publisher
    Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum...
  50. Chen C, Chiu Y, Shaw C, Tsai M, Hwang A, Hsiao K. Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers. Mol Psychiatry. 1999;4:566-71 pubmed
    Accumulating evidence suggests that Borna disease virus (BDV), a neurotropic, negative-stranded RNA virus, might be associated with certain human mental disorders...
  51. Hausmann J, Sauder C, Wasmer M, Lu B, Staeheli P. Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3. Viral Immunol. 2004;17:79-85 pubmed
    b>Borna disease virus (BDV) can induce severe neurological disorder in Lewis rats and MRL mice. Antiviral CD8 T cells have been shown to be the mediators of disease in these animals...
  52. Bode L, Ludwig H. Borna disease virus infection, a human mental-health risk. Clin Microbiol Rev. 2003;16:534-45 pubmed
    This article focuses on human Borna disease virus (BDV) infections, most notably on the development of valid diagnostic systems, which have arisen as a major research issue in the past decade...
  53. Pletnikov M, Rubin S, Moran T, Carbone K. Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain. Cerebellum. 2003;2:62-70 pubmed
    ..One of the most interesting in vivo models of virus-induced cerebellar damage is the neonatal Borna disease virus (BDV) infection of the rat brain...
  54. Vahlenkamp T, Enbergs H, Muller H. Experimental and natural borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Vet Microbiol. 2000;76:229-44 pubmed
    Cells of the peripheral blood of experimentally and naturally borna disease virus (BDV)-infected animals and of human psychiatric patients and healthy individuals were analyzed for the presence of viral RNA using a BDV-p40-specific ..
  55. Cotto E, Neau D, Cransac Neau M, Auriacombe M, Pellegrin J, Ragnaud J, et al. Borna disease virus RNA in immunocompromised patients in southwestern France. J Clin Microbiol. 2003;41:5577-81 pubmed
    b>Borna disease virus (BDV) is a neurotropic RNA virus with a wide host range. Human infections, although controversial, have been described in Europe, Asia, and the United States...
  56. Dietz D, Pletnikov M. Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infection. Physiol Behav. 2003;80:359-66 pubmed
    Neonatal Borna disease virus (BDV) infection of the rat's brain produces neurodevelopmental damage similar to some pathological and clinical features of human developmental disorders, e.g., autism and schizophrenia...
  57. Volmer R, Monnet C, Gonzalez Dunia D. Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling. PLoS Pathog. 2006;2:e19 pubmed
    Infection by Borna disease virus (BDV) enables the study of the molecular mechanisms whereby a virus can persist in the central nervous system and lead to altered brain function in the absence of overt cytolysis and inflammation...
  58. Schwemmle M, Billich C. The use of peptide arrays for the characterization of monospecific antibody repertoires from polyclonal sera of psychiatric patients suspected of infection by Borna Disease Virus. Mol Divers. 2004;8:247-50 pubmed
    b>Borna Disease Virus (BDV) is suspected to infect humans and to be associated with psychiatric disorders. To this date, BDV-reactive antibodies provide the only reliable markers to diagnose human BDV infection...
  59. Köster Patzlaff C, Hosseini S, Reuss B. Loss of connexin36 in rat hippocampus and cerebellar cortex in persistent Borna disease virus infection. J Chem Neuroanat. 2009;37:118-27 pubmed publisher
    Neonatal Borna disease virus (BDV) infection of the Lewis rat leads to progressive degeneration of dentate gyrus granule cells, and cerebellar Purkinje neurons...
  60. Sauder C, Hallensleben W, Pagenstecher A, Schneckenburger S, Biro L, Pertlik D, et al. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol. 2000;74:9267-80 pubmed
    b>Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) ..
  61. Pisoni G, Nativi D, Bronzo V, Codazza D. Sero-epidemiological study of Borna disease virus infection in the Italian equine population. Vet Res Commun. 2007;31 Suppl 1:245-8 pubmed
  62. Watanabe M, Lee B, Kamitani W, Kobayashi T, Taniyama H, Tomonaga K, et al. Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils. Virology. 2001;282:65-76 pubmed
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes a chronic neurological disease in a wide variety of animal species...
  63. Okamoto M, Hagiwara K, Kamitani W, Sako T, Hirayama K, Kirisawa R, et al. Experimental vertical transmission of Borna disease virus in the mouse. Arch Virol. 2003;148:1557-68 pubmed
    We demonstrated the experimental vertical transmission of Borna disease virus (BDV) in pregnant BALB/c mice. Giessen strain He/80 of BDV was used in the present study...
  64. Williams B, Yaddanapudi K, Hornig M, Lipkin W. Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection. J Virol. 2007;81:2675-87 pubmed
    Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life...
  65. Kinnunen P, Billich C, Ek Kommonen C, Henttonen H, Kallio R, Niemimaa J, et al. Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland. J Clin Virol. 2007;38:64-9 pubmed
    b>Borna disease virus (BDV) can infect many vertebrate species, including humans. BDV infection may lead to meningoencephalomyelitis in animals...
  66. Wensman J, Thoren P, Hakhverdyan M, Belak S, Berg M. Development of a real-time RT-PCR assay for improved detection of Borna disease virus. J Virol Methods. 2007;143:1-10 pubmed
    b>Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species...
  67. Tomonaga K, Kobayashi T, Ikuta K. [The neuropathogenesis of Borna disease virus infection]. Nihon Rinsho. 2001;59:1605-13 pubmed
    b>Borna disease virus(BDV) is a noncytolytic, neurotropic RNA virus that causes a disease of the central nervous system(CNS) in several vertebrate species, including horses, sheep, cats and ostriches...
  68. Köster Patzlaff C, Hosseini S, Reuss B. Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. Brain Res. 2008;1219:143-58 pubmed publisher
    Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain, leads to Purkinje cell degeneration, in association with astroglial activation...
  69. Ovanesov M, Sauder C, Rubin S, Richt J, Nath A, Carbone K, et al. Activation of microglia by borna disease virus infection: in vitro study. J Virol. 2006;80:12141-8 pubmed
    Neonatal Borna disease virus (BDV) infection of the rat brain is associated with microglial activation and damage to the certain neuronal populations...
  70. Kramer K, Schaudien D, Eisel U, Herzog S, Richt J, Baumgartner W, et al. TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures. PLoS ONE. 2012;7:e41476 pubmed publisher
    Proinflammatory state of the brain increases the risk for seizure development. Neonatal Borna disease virus (BDV)-infection of mice with neuronal overexpression of tumor necrosis factor-? (TNF) was used to investigate the complex ..
  71. Dietz D, Vogel M, Rubin S, Moran T, Carbone K, Pletnikov M. Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis. J Neurovirol. 2004;10:267-77 pubmed
    Neonatal Borna disease virus (BDV) infection of the rat brain serves as a valuable model for studying the pathogenesis of neurodevelopmental abnormalities following early brain injury...
  72. Brnic D, Stevanovic V, Cochet M, Agier C, Richardson J, Montero Menei C, et al. Borna disease virus infects human neural progenitor cells and impairs neurogenesis. J Virol. 2012;86:2512-22 pubmed publisher
    ..The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms...
  73. Ackermann A, Guelzow T, Staeheli P, Schneider U, Heimrich B. Visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing Borna disease virus vector. J Virol. 2010;84:5438-42 pubmed publisher
    b>Borna disease virus (BDV) frequently persists in the brain of infected animals. To analyze viral dissemination in the mouse nervous system, we generated a mouse-adapted virus that expresses green fluorescent protein (GFP)...
  74. Heinrich A, Adamaszek M. Anti-Borna disease virus antibody responses in psychiatric patients: long-term follow up. Psychiatry Clin Neurosci. 2010;64:255-61 pubmed publisher
    Data suggesting a pathogenetic role for Borna disease virus (BDV) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection...
  75. Li Y, Wang D, Zhang F, Liu Z, Yang A, Ykuta K. [Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003;17:330-3 pubmed
    To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.
  76. Carbone K, Duchala C, Griffin J, Kincaid A, Narayan O. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol. 1987;61:3431-40 pubmed
    b>Borna disease virus is an uncharacterized agent that causes sporadic but fatal neurological disease in horses and sheep in Europe...
  77. Taieb O, Baleyte J, Mazet P, Fillet A. Borna disease virus and psychiatry. Eur Psychiatry. 2001;16:3-10 pubmed
    b>Borna disease virus (BDV), a noncytolytic neurotropic nonsegmented negative-stranded RNA virus with a wide geographic distribution, infects several vertebrate animal species and causes an immune-mediated central nervous system (CNS) ..
  78. Wensman J, Jäderlund K, Gustavsson M, Hansson Hamlin H, Karlstam E, Lilliehöök I, et al. Markers of Borna disease virus infection in cats with staggering disease. J Feline Med Surg. 2012;14:573-82 pubmed publisher
    b>Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease...
  79. Inoue Y, Yamaguchi K, Sawada T, Rivero J, Horii Y. Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001. J Vet Med Sci. 2002;64:445-8 pubmed
    b>Borna disease virus (BDV)-specific antibodies were monitored in Misaki feral horses annually for 4 years using an electrochemiluminescence immunoassay (ECLIA). Among 130 horses examined, 35 (26...
  80. Watanabe Y, Yanai H, Ohtaki N, Ikuta K, Tomonaga K. Prevalence of Borna disease virus antibodies in healthy Japanese black cattle in Kyushu. J Vet Med Sci. 2006;68:171-4 pubmed
    Epidemiological studies have demonstrated that asymptomatic infection of Borna disease virus (BDV) is found in various species of animals in Japan...
  81. Hilbe M, Herrsche R, Kolodziejek J, Nowotny N, Zlinszky K, Ehrensperger F. Shrews as reservoir hosts of borna disease virus. Emerg Infect Dis. 2006;12:675-7 pubmed
    b>Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other animal species in central Europe...
  82. Nunes S, Itano E, Amarante M, Reiche E, Miranda H, de Oliveira C, et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal. 2008;22:314-20 pubmed publisher
    ..Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, ..
  83. Geib T, Sauder C, Venturelli S, Hässler C, Staeheli P, Schwemmle M. Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components. J Virol. 2003;77:4283-90 pubmed
    ..We present evidence for superinfection exclusion in brains of Borna disease virus (BDV)-infected rats and in persistently infected Vero cells, and we suggest that acquired resistance to ..