borna disease

Summary

Summary: An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.

Webpages

  1. title page for the overall tutorial
    www.vetmed.wisc.edu/pbs/zoonoses/
  2. annual report of unité des virus lents for year 2000
    www.pasteur.fr/recherche/RAR/RAR2000/Vlent-en.html
  3. taxonomy browser (mononegavirales
    www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=11157&fi ...
  4. combined program on microbiology and immunology. osaka university
    www.biken.osaka-u.ac.jp/COE/eng/project/pro07.html
  5. virology - research - urs schneider and team
    www.uniklinik-freiburg.de/virologie/live/forschung/teams/sch ...
  6. hyperkinesis
    lib.bioinfo.pl/meid:25849
  7. encephalitis, viral
    lib.bioinfo.pl/meid:281038
  8. taxonomy browser (bornaviridae
    www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=178830&f ...
  9. shalaby m a, wenta n, mauel s, borchers k, ludwig h, bode l: circulation of borna disease virus (with first gene sequences) and equine herpes viruses in egyptian horses
    early.vetmed.fu-berlin.de/fb-publikationen/64535.html
  10. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1788 ...

Research Grants

  1. Virus Vaccine Neurotoxicity Test Development
    K M Carbone; Fiscal Year: 2003
  2. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
  3. Vaccine Safety: Pathogenesis of virus vaccine neurotoxi
    K M Carbone; Fiscal Year: 2002
  4. Molecular Biology of Borna Disease Virus (BDV)
    Juan C de la Torre; Fiscal Year: 2004
  5. Viral neuropathology neuropeptides and epilepsy
    Marylou V Solbrig; Fiscal Year: 2005
  6. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou V Solbrig; Fiscal Year: 2002
  7. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER IAN LIPKIN; Fiscal Year: 2002
  8. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail V Pletnikov; Fiscal Year: 2008
  9. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail V Pletnikov; Fiscal Year: 2007
  10. Identification of Borna Disease Virus Receptor Proteins
    Juan C de la Torre; Fiscal Year: 2006

Publications

  1. Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes
    Yoshii Nishino
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:8650-8
  2. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant
    Marco Henkel
    Institute of Immunology, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany
    J Virol 79:314-25
  3. Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization
    Yoshio Hashimoto
    Department of Bioscience, Salem International University, Salem, West Virginia 26426-0500, USA
    J Virol 77:6076-81
  4. Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis
    E Furrer
    Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, Germany
    J Virol 75:943-51
  5. Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility
    Yohei Watanabe
    Department of Virology, Research Institute for Microbial Diseases BIKEN, Osaka University, Suita, Osaka 565 0871, Japan
    Microbes Infect 9:417-27
  6. Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats
    Marylou V Solbrig
    Emerging Diseases Laboratory, University of California-Irvine, Irvine, CA, USA
    Antimicrob Agents Chemother 46:2287-91
  7. Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation
    C Jehle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Arch Virol 148:45-63
  8. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus
    Karen Lancaster
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Behav Brain Res 176:141-8
  9. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79
  10. Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders
    Mikhail V Pletnikov
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Front Biosci 7:d593-607

Scientific Experts

Detail Information

Webpages14

  1. title page for the overall tutorial
    www.vetmed.wisc.edu/pbs/zoonoses/
  2. annual report of unité des virus lents for year 2000
    www.pasteur.fr/recherche/RAR/RAR2000/Vlent-en.html
  3. taxonomy browser (mononegavirales
    www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=11157&fi ...
  4. combined program on microbiology and immunology. osaka university
    www.biken.osaka-u.ac.jp/COE/eng/project/pro07.html
  5. virology - research - urs schneider and team
    www.uniklinik-freiburg.de/virologie/live/forschung/teams/sch ...
  6. hyperkinesis
    lib.bioinfo.pl/meid:25849
  7. encephalitis, viral
    lib.bioinfo.pl/meid:281038
  8. taxonomy browser (bornaviridae
    www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=178830&f ...
  9. shalaby m a, wenta n, mauel s, borchers k, ludwig h, bode l: circulation of borna disease virus (with first gene sequences) and equine herpes viruses in egyptian horses
    early.vetmed.fu-berlin.de/fb-publikationen/64535.html
  10. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1788 ...

Research Grants12

  1. Virus Vaccine Neurotoxicity Test Development
    K M Carbone; Fiscal Year: 2003
    ..signs of autism, we have developed a rat model of autism using neonatal infection with neurotropic viruse, Borna disease virus...
  2. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warm blooded animals to cause disturbances of movement and behavior...
  3. Vaccine Safety: Pathogenesis of virus vaccine neurotoxi
    K M Carbone; Fiscal Year: 2002
    ..signs of autism, we developed a rat model of autism using neonatal infection with neurotropic viruse, Borna disease virus...
  4. Molecular Biology of Borna Disease Virus (BDV)
    Juan C de la Torre; Fiscal Year: 2004
    DESCRIPTION (provided by applicant): Borna disease virus (BDV) provides an important model for the study of viral persistence4n the central nervous system (CNS), a subject relevant to health given the evidence that viruses can contribute ..
  5. Viral neuropathology neuropeptides and epilepsy
    Marylou V Solbrig; Fiscal Year: 2005
    ..The generality of the hypothesis, the mechanism of effect, and treatments will be studied. Borna Disease virus, a neurotropic virus causing hippocampal degeneration in many mamma an species, is a rare cause of ..
  6. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou V Solbrig; Fiscal Year: 2002
    ..An animal model of a persistent CNS viral infection based on experimental Borna disease virus infection of the rat will be developed then tested for 1) the reinforcing effects of opiates as measured ..
  7. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER IAN LIPKIN; Fiscal Year: 2002
    ..and either affective disorders or schizophrenia, a potential role in their pathogenesis has been suggested for Borna disease virus (BDV)...
  8. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail V Pletnikov; Fiscal Year: 2008
    ..continuation application, we propose to use our small animal model of viral neuropathogenesis, neonatal Borna disease virus infection (BDV), to study the mechanisms by which soluble neurotoxins (e.g...
  9. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail V Pletnikov; Fiscal Year: 2007
    ..continuation application, we propose to use our small animal model of viral neuropathogenesis, neonatal Borna disease virus infection (BDV), to study the mechanisms by which soluble neurotoxins (e.g...
  10. Identification of Borna Disease Virus Receptor Proteins
    Juan C de la Torre; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Borna disease virus (BDV) is an enveloped virus with a non-segmented negative strand (NNS) RNA genome. Because of its unique features BDV is the prototypic member of a new virus family...
  11. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER IAN LIPKIN; Fiscal Year: 2004
    ..This project will explore an animal model of autism based on CNS infection in early life. Borna disease virus (BDV) is a newly classified RNA virus that infects the CNS of warmblooded animals to cause disturbances ..
  12. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER IAN LIPKIN; Fiscal Year: 2002
    This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular ..

Publications62

  1. Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes
    Yoshii Nishino
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:8650-8
    b>Borna disease virus (BDV) infection produces a variety of clinical diseases, from behavioral illnesses to classical fatal encephalitis (i.e., Borna disease [BD])...
  2. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant
    Marco Henkel
    Institute of Immunology, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany
    J Virol 79:314-25
    ..Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus, which represents a major antigen for the induction of a Borna disease virus-specific humoral and ..
  3. Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization
    Yoshio Hashimoto
    Department of Bioscience, Salem International University, Salem, West Virginia 26426-0500, USA
    J Virol 77:6076-81
    b>Borna disease virus (BDV) infection of Lewis rats is the most studied animal model of Borna disease, an often fatal encephalomyelitis...
  4. Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis
    E Furrer
    Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, Germany
    J Virol 75:943-51
    b>Borna disease virus (BDV) infection triggers an immune-mediated encephalomyelitis and results in a persistent infection...
  5. Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility
    Yohei Watanabe
    Department of Virology, Research Institute for Microbial Diseases BIKEN, Osaka University, Suita, Osaka 565 0871, Japan
    Microbes Infect 9:417-27
    To investigate the biological characteristics of field isolates of Borna disease virus (BDV), as well as to understand BDV infections outside endemic countries, we isolated the virus from brain samples of a heifer with Borna disease in ..
  6. Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats
    Marylou V Solbrig
    Emerging Diseases Laboratory, University of California-Irvine, Irvine, CA, USA
    Antimicrob Agents Chemother 46:2287-91
    In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid...
  7. Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation
    C Jehle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Arch Virol 148:45-63
    Infection of newborn rats with Borna disease virus (BDV) leads to viral persistence in the central nervous system without overt signs of inflammation...
  8. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus
    Karen Lancaster
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Behav Brain Res 176:141-8
    ..In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats...
  9. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79
    Infection of adult rats with Borna disease virus (BDV) causes CD8 T cell-mediated meningoencephalitis. Previously, we described a complex pattern of chemokine gene expression in the central nervous system (CNS) of such rats...
  10. Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders
    Mikhail V Pletnikov
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Front Biosci 7:d593-607
    ..The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of ..
  11. Implications for a regulated replication of Borna disease virus in brains of experimentally infected Lewis rats
    Doris Porombka
    Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
    Virus Genes 36:415-20
    The neurotropic Borna disease virus (BDV) causes typically a persistent virus infection of the central nervous system...
  12. No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
    S Kamhieh
    Northern Blood Research Centre, St. Leonards, NSW, Australia
    Arch Virol 151:709-19
    b>Borna disease virus (BDV) is a unique RNA virus that is a cause of neurological disease in horses, sheep and cats. The finding that BDV also infects humans has raised concern related to the impact of infection with this virus...
  13. Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus
    C Herden
    Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, D 30559 Hannover, Germany
    Neuropathol Appl Neurobiol 31:512-21
    Experimental infection of Lewis rats with Borna disease virus (BDV) causes an immune-mediated nonpurulent meningoencephalitis...
  14. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus
    B L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Virol 80:8613-26
    b>Borna disease virus infection of neonatal rats results in a characteristic behavioral syndrome and apoptosis of subsets of neurons in the hippocampus and cerebellum (neonatal Borna disease [NBD])...
  15. Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection
    Brent L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm 1801, New York, NY 10032, USA
    J Virol 81:2675-87
    Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life...
  16. Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90
    ..We present evidence for superinfection exclusion in brains of Borna disease virus (BDV)-infected rats and in persistently infected Vero cells, and we suggest that acquired resistance to ..
  17. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease
    M Hornig
    Laboratory for the Study of Emerging Diseases, 3101 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697-4292, USA
    Curr Top Microbiol Immunol 253:157-77
    ..Two models have been established based on Borna disease virus infection that provide new insights into mechanisms by which neurotropic agents and/or immune factors ..
  18. Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration
    Michael Bacher
    Institute of Immunology, Philipps University, Marburg, Germany
    Glia 37:291-306
    ..invasion during virus-induced encephalitis, we analyzed the expression and cellular localization of MIF in the Borna disease virus (BDV)-infected rat brain, monitored monocyte/macrophage infiltration, and evaluated the influence of ..
  19. Precursors of Borna disease virus-specific T cells in secondary lymphatic tissue of experimentally infected rats
    Arvind Batra
    Institute for Immunology, Federal Research Center for Virus Diseases of Animals, Tübingen, Federal Republic of Germany
    J Neurovirol 9:325-35
    b>Borna disease in rats represents an experimental model to study the immunopathological role of T cells in central nervous system disease...
  20. Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils
    M Watanabe
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Virology 282:65-76
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes a chronic neurological disease in a wide variety of animal species...
  21. Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus
    Naohiro Ohtaki
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 81:5940-8
    b>Borna disease virus (BDV) is a neurotropic virus that causes a persistent infection in the central nervous system (CNS) of many vertebrate species...
  22. 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread
    Jeffrey J Bajramovic
    Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France
    J Virol 76:6268-76
    b>Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis...
  23. Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differences
    C Sauder
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
    Arch Virol 149:2171-86
    b>Borna disease virus (BDV) infection in its predominant natural host - horses and sheep - leads to fatal meningoencephalomyelitis...
  24. Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity
    Andreas Ackermann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 81:7933-40
    b>Borna disease virus (BDV) can persistently infect the central nervous system of a broad range of mammalian species...
  25. Nosological study of Borna disease virus infection in race horses
    Katsuro Hagiwara
    Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Vet Microbiol 84:367-74
    To investigate the prevalence of diseases in the Borna disease virus (BDV) antibody positive race horses, we undertook seroepidemiological studies of BDV infection on 125 culled race horses in Hokkaido, Japan...
  26. Infection of the enteric nervous system by Borna disease virus (BDV) upregulates expression of Calbindin D-28k
    Helga Pfannkuche
    Institute of Veterinary Physiology, Faculty of Veterinary Medicine, An den Tierkliniken 7, Leipzig University, 04103 Leipzig, Germany
    Vet Microbiol 127:275-85
    b>Borna disease virus (BDV) is a neurotropic agent infecting distinct neuronal subpopulations in the central nervous system of various mammalian species possibly including humans...
  27. Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value
    U Allmang
    Abteilung Virologie, Institut für Medizinische Mikrobiologie and Hygiene, Universität Freiburg, D-79104 Freiburg, Germany
    Mol Psychiatry 6:329-33
    b>Borna disease virus (BDV) can induce neurological disease in animals...
  28. High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins
    Christian Billich
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 51:979-87
    BACKGROUND: The recent observation that Borna disease virus (BDV)-reactive antibodies from psychiatric patients exhibit only low avidity for BDV antigen called into question their diagnostic value and raised the possibility that ..
  29. Persistence of Borna disease virus in naturally infected sheep
    Thomas W Vahlenkamp
    Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany
    J Virol 76:9735-43
    To get an insight into Borna disease virus (BDV) epidemiology, an isolated flock of approximately 25 sheep within the region of Southeast Germany to which the disease is endemic was investigated over a 3-year observation period...
  30. Borna disease virus
    I Jordan
    Emerging Diseases Laboratory, Department of Neurology, University of California-- Irvine, Irvine, California 92697-4292, USA
    Rev Med Virol 11:37-57
    b>Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species...
  31. Borna disease virus--does it infect humans and cause psychiatric disorders?
    K Lieb
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    J Clin Virol 21:119-27
    Antibodies recognizing Borna disease virus (BDV) antigens were first demonstrated in the blood of psychiatric patients approximately 15 years ago...
  32. [Borna disease virus infection]
    Wataru Kamitani
    Department of Virology, Research Institute for Microbial Diseases, Osaka University
    Nippon Rinsho 61:128-34
  33. Experimental infection of mice with Borna disease virus (BDV): replication and distribution of the virus after intracerebral infection
    H K Enbergs
    Institute of Virology, Faculty of Veterinary Medicine, Leipzig, Germany
    J Neurovirol 7:272-7
    To develop an animal model resembling natural asymptomatic Borna disease virus (BDV) infections, BDV He/80 rat brain homogenate was passaged four times in adult SJL/J mice...
  34. Detection of antibodies to Borna disease virus (BDV) in Turkish horse sera using recombinant p40. Brief report
    H Yilmaz
    University of Istanbul, Veterinary Faculty, Department of Microbiology, Avcilar, Turkey
    Arch Virol 147:429-35
    The nucleoprotein of Borna disease virus (BDV-p40) was produced in a Baculovirus expression system using sf9 cells. The purity and specificity of the recombinant p40 was confirmed by SDS-PAGE and immunoblotting...
  35. Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats
    Marylou V Solbrig
    Department of Neurology, University of California Irivne, Irvine, California 92697 4292, USA
    J Neurovirol 14:252-60
    ..b>Borna disease virus (BDV) in rats causes cortical and subcortical infection with extrapyramidal motor symptoms, and ..
  36. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection
    Brent L Williams
    Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Brain Pathol 16:1-14
    Neonatal Borna disease (NBD) virus infection in the Lewis rat results in life-long viral persistence and causes behavioral and neurodevelopmental abnormalities...
  37. Key role for enkephalinergic tone in cortico-striatal-thalamic function
    Marylou V Solbrig
    Department of Neurology, Gillespie Neuroscience Bldg, Rm 3107, University of California Irvine, Irvine, CA 92697 4292, USA
    Eur J Neurosci 16:1819-22
    ..We show that Borna disease virus infection of adult rats results in an increase in preproenkephalin transcripts in the striatum of Borna-..
  38. Characterization of the acute immune response in the retina of Borna disease virus infected Lewis rats
    Tobias Stahl
    Department of Veterinary Anatomy, University of Leipzig, An den Tierkliniken 43 D 04109 Leipzig, Germany
    J Neuroimmunol 137:67-78
    In Lewis rats infected intracerebrally with the highly neurotropic Borna disease virus (BDV), the retina is one of the most severely affected central nervous system (CNS) structures...
  39. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
    C Sauder
    Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D 79104 Freiburg
    J Virol 74:9267-80
    b>Borna disease virus (BDV) causes CD8(+) T-cell-mediated meningoencephalitis in immunocompetent mice and rats, thus providing a valuable animal model for studying the mechanisms of virus-induced central nervous system (CNS) ..
  40. Experimental vertical transmission of Borna disease virus in the mouse
    M Okamoto
    Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Arch Virol 148:1557-68
    We demonstrated the experimental vertical transmission of Borna disease virus (BDV) in pregnant BALB/c mice. Giessen strain He/80 of BDV was used in the present study...
  41. Bornavirus and the brain
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM 6, Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S241-7
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities. BDV is a nonsegmented, negative, single-stranded RNA virus...
  42. Age- and host-dependent control of Borna disease virus spread in the developing brains of gerbils and rats
    Byeong-Jae Lee
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
    Microbes Infect 5:1195-204
    b>Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that has a broad host range in warm-blooded animals, probably including humans...
  43. Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells
    Daniel Mayer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    J Virol 79:11716-23
    In the hippocampus of Borna disease virus (BDV)-infected newborn rats, dentate granule cells undergo progressive cell death...
  44. Borna disease in a dog in Japan
    M Okamoto
    Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido, 069-8501, Japan
    J Comp Pathol 126:312-7
    b>Borna disease (BD) was diagnosed in a 3-year-old male Welsh corgi suffering from a severe and acute progressive disorder of the central nervous system...
  45. Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication
    Soizic Bourteele
    Institut für Immunologie, Friedrich Loeffler Institut, Bundesforschungsinstitut für Tiergesundheit, Paul Ehrlich Str. 28, 72076 Tübingen, Germany
    J Virol 79:6043-51
    ..b>Borna disease virus (BDV) is a neurotropic negative-strand RNA virus, which replicates in the nucleus of the infected cell ..
  46. Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells
    P Staeheli
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 75:8216-23
    b>Borna disease virus (BDV) is a noncytolytic RNA virus that can replicate in the central nervous system (CNS) of mice...
  47. Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell destructions
    Makiko Watanabe
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
    Virology 310:245-53
    b>Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that is known to cause neurological disturbances in various animal species...
  48. Detection by radioligand assay of antibodies against Borna disease virus in patients with various psychiatric disorders
    Hidenori Matsunaga
    Department of Psychiatry, Osaka General Medical Center, Bandai higashi 3 1 56, Sumiyoshi ku, Osaka 558 8558, Japan
    Clin Diagn Lab Immunol 12:671-6
    Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively...
  49. Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia
    A Ouchi
    Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, Inashiki-gun, Ibaraki, Japan
    J Vet Med Sci 63:1279-85
    Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46...
  50. Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts
    A R Schindler
    Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 266a, CH 8057 Zurich, Switzerland
    Mol Cell Probes 21:47-55
    b>Borna disease is a severe, immunopathological disorder of the central nervous system caused by the infection with the Borna disease virus (BDV)...
  51. Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan
    K Fukuda
    Department of Microbiology, Fukushima Medical University, Fukushima-shi, Fukushima 960-1295, Japan
    J Clin Microbiol 39:419-29
    The involvement of Borna disease virus (BDV) in psychiatric diseases in humans remains controversial...
  52. Genetic relationship of Borna disease virus isolates
    Oliver Planz
    Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen
    Virus Genes 26:25-30
    ..We also present data that BDV-specific nucleic acid detected in blood of the donor of the presumed RW98 isolate and one other patient differs from all known BDV-p24 sequences, arguing for the existence of BDV sequences in man...
  53. Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients
    Helen Cristina Miranda
    Department of Pathological Sciences-Immunology, Londrina State University, Londrina, PR, Brazil
    J Affect Disord 90:43-7
    BACKGROUND: Borna disease virus (BDV) is a virus that naturally infects a broad range of warm-blooded animals...
  54. Molecular biology of Borna disease virus and persistence
    Juan Carlos de la Torre
    Department of Neuropharmacology, Division of Virology, IMM-6, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Front Biosci 7:d569-79
    b>Borna disease virus (BDV) causes central nervous system (CNS) disease that is frequently manifested by behavioral abnormalities...
  55. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives
    Sandra Odebrechet Vargas Nunes
    Department of Psychiatry, State University of Londrina, Londrina, PR, Brazil
    J Clin Lab Anal 22:314-20
    ..Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, ..
  56. PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection
    Akikazu Sakudo
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 431:81-5
    Our previous studies have shown that the persistent expression of Borna disease virus phosphoprotein (BDV P) in mice leads to behavioral abnormalities resembling those in BDV-infected animals...
  57. [The mechanism of persistent infection and pathogenesis of Borna disease virus]
    Keizo Tomonaga
    Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871
    Uirusu 53:103-12
  58. Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D-79104 Freiburg, Germany
    J Virol 78:3621-32
    The nucleoprotein (N) of Borna disease virus (BDV) is the major target of the disease-inducing antiviral CD8 T-cell response in the central nervous system of mice...