arenaviridae infections

Summary

Summary: Virus diseases caused by the ARENAVIRIDAE.

Top Publications

  1. Enria D, Barrera Oro J. Junin virus vaccines. Curr Top Microbiol Immunol. 2002;263:239-61 pubmed
  2. Milazzo M, Barragan Gomez A, Hanson J, Estrada Franco J, Arellano E, González Cózatl F, et al. Antibodies to Tacaribe serocomplex viruses (family Arenaviridae, genus Arenavirus) in cricetid rodents from New Mexico, Texas, and Mexico. Vector Borne Zoonotic Dis. 2010;10:629-37 pubmed publisher
    ..Comparison of endpoint antibody titers to Whitewater Arroyo virus and Amaparí virus in individual blood samples indicated that the Tacaribe complex viruses enzootic in Texas and Mexico are antigenically diverse. ..
  3. Cornu T, Feldmann H, de la Torre J. Cells expressing the RING finger Z protein are resistant to arenavirus infection. J Virol. 2004;78:2979-83 pubmed
    ..These findings open new avenues for developing antiviral strategies to combat the highly pathogenic human arenaviruses, including LFV. ..
  4. Gowen B, Smee D, Wong M, Pace A, Jung K, Bailey K, et al. Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters. Antivir Chem Chemother. 2006;17:175-83 pubmed
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity. ..
  5. Gowen B, Bray M. Progress in the experimental therapy of severe arenaviral infections. Future Microbiol. 2011;6:1429-41 pubmed publisher
    ..In this paper, we review current developments in the experimental therapy of severe arenaviral infections, focusing on drugs that have been tested in animal models, and provide a perspective on future research. ..
  6. Wherry E, Barber D, Kaech S, Blattman J, Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A. 2004;101:16004-9 pubmed
    ..These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors. ..
  7. de la Torre J. Molecular and cell biology of the prototypic arenavirus LCMV: implications for understanding and combating hemorrhagic fever arenaviruses. Ann N Y Acad Sci. 2009;1171 Suppl 1:E57-64 pubmed publisher
    ..This, in turn, should facilitate the development of novel both vaccines and antiviral drugs to combat the dual threats of naturally occurring and intentionally introduced arenavirus infections...
  8. Fischer S, Graham M, Kuehnert M, Kotton C, Srinivasan A, Marty F, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354:2235-49 pubmed
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  9. Goñi S, Iserte J, Ambrosio A, Romanowski V, Ghiringhelli P, Lozano M. Genomic features of attenuated Junín virus vaccine strain candidate. Virus Genes. 2006;32:37-41 pubmed
    ..These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains...

More Information

Publications90

  1. Shah W, Peng H, Carbonetto S. Role of non-raft cholesterol in lymphocytic choriomeningitis virus infection via alpha-dystroglycan. J Gen Virol. 2006;87:673-8 pubmed
    ..This may reflect the association of DG with cholesterol outside lipid rafts and suggests that association of DG with non-raft cholesterol is critical for infection by LCMV through alpha-DG. ..
  2. Clegg J. Molecular phylogeny of the arenaviruses. Curr Top Microbiol Immunol. 2002;262:1-24 pubmed
  3. Palacios G, Druce J, Du L, Tran T, Birch C, Briese T, et al. A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med. 2008;358:991-8 pubmed publisher
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...
  4. Inizan C, Cajimat M, Milazzo M, Barragan Gomez A, Bradley R, Fulhorst C. Genetic evidence for a tacaribe serocomplex virus, Mexico. Emerg Infect Dis. 2010;16:1007-10 pubmed publisher
    ..Analyses of nucleotide and amino acid sequence data indicated that the woodrats were infected with a novel Tacaribe serocomplex virus, proposed name Real de Catorce virus. ..
  5. Gonzalez J, Emonet S, De Lamballerie X, Charrel R. Arenaviruses. Curr Top Microbiol Immunol. 2007;315:253-88 pubmed
    ..The diversity among rodent host reservoir and virus species and the potential to exchange genomic material provide a basis for the emergence of new viruses and the risk of these becoming pathogenic for humans...
  6. Vieth S, Drosten C, Lenz O, Vincent M, Omilabu S, Hass M, et al. RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene. Trans R Soc Trop Med Hyg. 2007;101:1253-64 pubmed
  7. Fulhorst C, Milazzo M, Bradley R, Peppers L. Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). Am J Trop Med Hyg. 2001;65:147-51 pubmed
    ..These results indicate that the duration of WWA virus infection in N. albigula is dependent upon the animal's age at the onset of infection and that neonatal infection can result in chronic (perhaps lifelong) virus shedding...
  8. Grande Pérez A, Lázaro E, Lowenstein P, Domingo E, Manrubia S. Suppression of viral infectivity through lethal defection. Proc Natl Acad Sci U S A. 2005;102:4448-52 pubmed
    ..The results bear on a potential application of increased mutagenesis as an antiviral strategy in that low doses of a mutagenic agent may suffice to drive persistent virus to extinction. ..
  9. Gonzalez J, Sanchez A, Rico Hesse R. Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting humans. Am J Trop Med Hyg. 1995;53:1-6 pubmed
    ..Along with its host restriction and focal distribution, our data support the hypothesis that this virus has been evolving independently in its endemic focus, for some time. ..
  10. Madakamutil L, Christen U, Lena C, Wang Zhu Y, Attinger A, Sundarrajan M, et al. CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science. 2004;304:590-3 pubmed
    ..Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha. ..
  11. Gowen B, Smee D, Wong M, Hall J, Jung K, Bailey K, et al. Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin. PLoS ONE. 2008;3:e3725 pubmed publisher
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  12. Mueller S, Hosiawa Meagher K, Konieczny B, Sullivan B, Bachmann M, Locksley R, et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007;317:670-4 pubmed
    ..We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues. ..
  13. Kotturi M, Botten J, Sidney J, Bui H, Giancola L, Maybeno M, et al. A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease. PLoS Pathog. 2009;5:e1000695 pubmed publisher
    ..In conclusion, the set of identified epitopes allows broad, non-ethnically biased coverage of all 7 viral species targeted by our studies...
  14. Hugot J, Gonzalez J, Denys C. Evolution of the Old World Arenaviridae and their rodent hosts: generalized host-transfer or association by descent?. Infect Genet Evol. 2001;1:13-20 pubmed
    ..This supposes that the origin of the arenaviruses has to be found out of Africa...
  15. Sullivan J, Kim E, Plisch E, Peng S, Suresh M. FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog. 2012;8:e1002533 pubmed publisher
    ..In summary, we have identified FOXO3 as a critical regulator of CD8 T cell memory, and therapeutic modulation of FOXO3 might enhance vaccine-induced protective immunity against intracellular pathogens...
  16. Liang Y, Lan S, Ly H. Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers. Ann N Y Acad Sci. 2009;1171 Suppl 1:E65-74 pubmed publisher
    ..We have recently developed molecular clones for both the virulent and avirulent strains of PICV. Using the available reverse genetics tools, we are characterizing the molecular determinants of virulent arenavirus infections in vivo...
  17. Lee A, Rojek J, Spiropoulou C, Gundersen A, Jin W, Shaginian A, et al. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem. 2008;283:18734-42 pubmed publisher
  18. Peters C. Lymphocytic choriomeningitis virus--an old enemy up to new tricks. N Engl J Med. 2006;354:2208-11 pubmed
  19. Clegg J. Current progress towards vaccines for arenavirus-caused diseases. Vaccine. 1992;10:89-95 pubmed
  20. Lang K, Recher M, Navarini A, Harris N, Löhning M, Junt T, et al. Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol. 2005;35:738-45 pubmed
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  21. Lang P, Lang K, Xu H, Grusdat M, Parish I, Recher M, et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012;109:1210-5 pubmed publisher
    ..Therefore, we identified an important role of regulatory NK cells in limiting T-cell immunity during virus infection...
  22. Zhou S, Kurt Jones E, Cerny A, Chan M, Bronson R, Finberg R. MyD88 intrinsically regulates CD4 T-cell responses. J Virol. 2009;83:1625-34 pubmed publisher
  23. Fennewald S, Aronson J, Zhang L, Herzog N. Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo. J Virol. 2002;76:1154-62 pubmed
    ..Taken together, these changes suggest that the attenuated viral strain induces an "activation" of macrophages, while the virulent form of the virus does not...
  24. Barton L, Mets M, Beauchamp C. Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am J Obstet Gynecol. 2002;187:1715-6 pubmed
    ..We strongly suggest that obstetricians counsel their pregnant patients regarding the potential hazard that contact with infected pet, laboratory, and household mice and hamsters poses to pregnant women and their unborn children...
  25. Kolokoltsova O, Yun N, Poussard A, Smith J, Smith J, Salazar M, et al. Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection. J Virol. 2010;84:13063-7 pubmed publisher
    ..After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease...
  26. de la Torre J. Arenavirus extinction through lethal mutagenesis. Virus Res. 2005;107:207-14 pubmed
    ..These findings indicate that, as with other riboviruses, lethal mutagenesis is effective also against LCMV raising the possibility of using this novel antiviral strategy to combat pathogenic arenaviruses...
  27. Radoshitzky S, Kuhn J, Spiropoulou C, Albarino C, Nguyen D, Salazar Bravo J, et al. Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses. Proc Natl Acad Sci U S A. 2008;105:2664-9 pubmed publisher
  28. Seregin A, Yun N, Poussard A, Peng B, Smith J, Smith J, et al. TC83 replicon vectored vaccine provides protection against Junin virus in guinea pigs. Vaccine. 2010;28:4713-8 pubmed publisher
    ..This is the first scientific report to our knowledge that the immune response against GPC alone is sufficient to prevent lethal disease against JUNV in an animal model...
  29. Salazar Bravo J, Ruedas L, Yates T. Mammalian reservoirs of arenaviruses. Curr Top Microbiol Immunol. 2002;262:25-63 pubmed
  30. García C, Ellenberg P, Artuso M, Scolaro L, Damonte E. Characterization of Junín virus particles inactivated by a zinc finger-reactive compound. Virus Res. 2009;143:106-13 pubmed publisher
  31. Neuman B, Bederka L, Stein D, Ting J, Moulton H, Buchmeier M. Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors. Antimicrob Agents Chemother. 2011;55:4631-8 pubmed publisher
    ..These results suggest that arenavirus 5' genomic termini represent promising targets for pan-arenavirus antiviral therapeutic development...
  32. Zapata J, Pauza C, Djavani M, Rodas J, Moshkoff D, Bryant J, et al. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. Antiviral Res. 2011;92:125-38 pubmed publisher
    ..By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets...
  33. Emonet S, Seregin A, Yun N, Poussard A, Walker A, de la Torre J, et al. Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease. J Virol. 2011;85:1473-83 pubmed publisher
    ..In addition, we rescued Candid #1 viruses with three segments that efficiently expressed foreign genes introduced into their genomes. This finding opens the way for the development of a safe multivalent arenavirus vaccine...
  34. Botten J, Whitton J, Barrowman P, Sidney J, Whitmire J, Alexander J, et al. A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. J Virol. 2010;84:9947-56 pubmed publisher
  35. Bennett S, Milazzo M, Webb J, Fulhorst C. Arenavirus antibody in rodents indigenous to coastal southern California. Am J Trop Med Hyg. 2000;62:626-30 pubmed
  36. Lecompte E, ter Meulen J, Emonet S, Daffis S, Charrel R. Genetic identification of Kodoko virus, a novel arenavirus of the African pigmy mouse (Mus Nannomys minutoides) in West Africa. Virology. 2007;364:178-83 pubmed
    ..The finding of an Old World arenavirus related to LCMV outside the known geographical range of LCMV in a novel rodent species reveals new insights about the evolutionary history of arenaviruses...
  37. Charrel R, De Lamballerie X. Zoonotic aspects of arenavirus infections. Vet Microbiol. 2010;140:213-20 pubmed publisher
    ..The approach based on consensus degenerate primers has shown efficient for both detection of known arenaviruses, and discovery of new arenaviruses...
  38. Paweska J, Sewlall N, Ksiazek T, Blumberg L, Hale M, Lipkin W, et al. Nosocomial outbreak of novel arenavirus infection, southern Africa. Emerg Infect Dis. 2009;15:1598-602 pubmed publisher
    ..Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined...
  39. Nguyen K, Watford W, Salomon R, Hofmann S, Pien G, Morinobu A, et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science. 2002;297:2063-6 pubmed
    ..Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs...
  40. Kolumam G, Thomas S, Thompson L, Sprent J, Murali Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med. 2005;202:637-50 pubmed
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  41. Nunberg J, York J. The curious case of arenavirus entry, and its inhibition. Viruses. 2012;4:83-101 pubmed publisher
    ..This unusual solution to maintaining the metastable prefusion state of GPC on the virion and activating the class I fusion cascade at acidic pH provides novel targets for antiviral intervention...
  42. Sbrana E, Mateo R, Xiao S, Popov V, Newman P, Tesh R. Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever. Am J Trop Med Hyg. 2006;74:1096-102 pubmed
  43. Jay M, Glaser C, Fulhorst C. The arenaviruses. J Am Vet Med Assoc. 2005;227:904-15 pubmed
  44. Geuking M, Weber J, Dewannieux M, Gorelik E, Heidmann T, Hengartner H, et al. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration. Science. 2009;323:393-6 pubmed publisher
    ..Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans...
  45. Albarino C, Bird B, Chakrabarti A, Dodd K, Flint M, Bergeron E, et al. The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain. J Virol. 2011;85:10404-8 pubmed publisher
    ..This work provides insight into the molecular mechanisms of attenuation of the only arenavirus vaccine currently available...
  46. Sepúlveda C, Fascio M, Mazzucco M, Palacios M, Pellón R, García C, et al. Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses. Antivir Chem Chemother. 2008;19:41-7 pubmed
    ..In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV)...
  47. Kunz S, Sevilla N, McGavern D, Campbell K, Oldstone M. Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan. J Cell Biol. 2001;155:301-10 pubmed
    ..Infection followed by dysfunction of these antigen-presenting cells contributes to immunosuppression and persistent viral infection in vivo...
  48. Laakkonen J, Kallio E, Kallio Kokko H, Vapalahti O, Vaheri A, Henttonen H. Is there an association of Pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in Finland?. Parasitology. 2006;132:461-6 pubmed
    ..Concurrent presence of virus antibodies (LCMV) and cyst forms of Pneumocystis were detected only in 1 M. minutus. In conclusion, we found no evidence of any association between Pneumocystis and antibodies to any of the viruses tested...
  49. Flatz L, Hegazy A, Bergthaler A, Verschoor A, Claus C, Fernandez M, et al. Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nat Med. 2010;16:339-45 pubmed publisher
    ..These features, together with low seroprevalence in humans, suggest that rLCMV may show utility as a vaccine platform against infectious diseases and cancer. ..
  50. Bradfute S, Stuthman K, Shurtleff A, Bavari S. A STAT-1 knockout mouse model for Machupo virus pathogenesis. Virol J. 2011;8:300 pubmed publisher
    ..This is due, in part, to a paucity of small animal models for MACV infection in which to discover and explore candidate therapeutics...
  51. Ishii A, Thomas Y, Moonga L, Nakamura I, Ohnuma A, Hang ombe B, et al. Novel arenavirus, Zambia. Emerg Infect Dis. 2011;17:1921-4 pubmed publisher
    ..Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus-related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses...
  52. Damonte E, Coto C. Treatment of arenavirus infections: from basic studies to the challenge of antiviral therapy. Adv Virus Res. 2002;58:125-55 pubmed
  53. Dejean A, Beisner D, Ch en I, Kerdiles Y, Babour A, Arden K, et al. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009;10:504-13 pubmed publisher
    ..Thus, Foxo3 acts to constrain the production of key inflammatory cytokines by dendritic cells and to control T cell survival...
  54. Bowick G, Spratt H, Hogg A, Endsley J, Wiktorowicz J, Kurosky A, et al. Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection. J Virol. 2009;83:687-700 pubmed publisher
    ..This study provides a number of differentially expressed targets for further research and suggests that key events in pathogenesis may be established early in infection...
  55. Gowen B, Holbrook M. Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses. Antiviral Res. 2008;78:79-90 pubmed
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  56. Cogswell Hawkinson A, Bowen R, James S, Gardiner D, Calisher C, Adams R, et al. Tacaribe virus causes fatal infection of an ostensible reservoir host, the Jamaican fruit bat. J Virol. 2012;86:5791-9 pubmed publisher
    ..Uninoculated cage mates failed to seroconvert, and viral RNA was not detected in their tissues, suggesting that transmission did not occur. Together, these data suggest that A. jamaicensis bats may not be a reservoir host for TCRV...
  57. Lukashevich I, Tikhonov I, Rodas J, Zapata J, Yang Y, Djavani M, et al. Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. J Virol. 2003;77:1727-37 pubmed
    ..Our data confirm that acute infection is associated with weak inflammatory responses in tissues and initiates a program of liver regeneration in primates...
  58. Wilson E, Yamada D, Elsaesser H, Herskovitz J, DENG J, Cheng G, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013;340:202-7 pubmed publisher
    ..Thus, we demonstrated that interfering with chronic IFN-I signaling during persistent infection redirects the immune environment to enable control of infection...
  59. Gowen B, Ennis J, Russell A, Sefing E, Wong M, Turner J. Use of recombinant adenovirus vectored consensus IFN-? to avert severe arenavirus infection. PLoS ONE. 2011;6:e26072 pubmed publisher
    ..The DEF201 technology has the potential to address all of these issues and may serve as a broad-spectrum antiviral to enhance host defense against a number of viral pathogens...
  60. Botten J, Sidney J, Mothe B, Peters B, Sette A, Kotturi M. Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev. 2010;74:157-70 pubmed publisher
    ..This review summarizes the findings from our studies and discusses their application to future vaccine design...
  61. Gowen B, Wong M, Jung K, Sanders A, Mendenhall M, Bailey K, et al. In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections. Antimicrob Agents Chemother. 2007;51:3168-76 pubmed
    ..Our results suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections...
  62. Pasquato A, Rochat C, Burri D, Pasqual G, de la Torre J, Kunz S. Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242. Virology. 2012;423:14-22 pubmed publisher
    ..Notably, PF-429242 was able to efficiently and rapidly clear persistent infection by arenaviruses. Interruption of drug treatment did not result in re-emergence of infection, indicating that PF-429242 treatment leads to virus extinction...
  63. Thomas C, Casquilho Gray H, York J, Decamp D, Dai D, Petrilli E, et al. A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus. J Biol Chem. 2011;286:6192-200 pubmed publisher
    ..This work expands our mechanistic understanding of arenavirus entry and provides a foundation to guide the development of small molecule compounds for the treatment of arenavirus hemorrhagic fevers...
  64. Popkin D, Teijaro J, Sullivan B, Urata S, Rutschmann S, de la Torre J, et al. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host Microbe. 2011;9:212-222 pubmed publisher
    ..These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections...
  65. Ha S, Mueller S, Wherry E, Barber D, Aubert R, Sharpe A, et al. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med. 2008;205:543-55 pubmed publisher
    ..Such an approach may have broad applications in developing treatment strategies for chronic infections in general, and perhaps also for tumors...
  66. Baize S, Marianneau P, Loth P, Reynard S, Journeaux A, Chevallier M, et al. Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys. J Virol. 2009;83:5890-903 pubmed publisher
  67. Fulhorst C, Cajimat M, Milazzo M, Paredes H, de Manzione N, Salas R, et al. Genetic diversity between and within the arenavirus species indigenous to western Venezuela. Virology. 2008;378:205-13 pubmed publisher
    ..Thus, passive antibody therapy may prove beneficial in the treatment of human disease caused by strains of Guanarito virus that are enzootic in the region in which Venezuelan hemorrhagic fever is endemic...
  68. Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, et al. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88. J Virol. 2008;82:196-206 pubmed
    ..Furthermore, the activation of a MyD88-dependent innate mechanism induces a CTL response, which eventually leads to virus elimination...
  69. Bowick G, Fennewald S, Elsom B, Aronson J, Luxon B, Gorenstein D, et al. Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections. J Virol. 2006;80:10248-52 pubmed
    ..By analyzing protein level changes using pathway analysis, we have identified key intermediates which may be targets for therapeutic intervention...
  70. Recher M, Lang K, Hunziker L, Freigang S, Eschli B, Harris N, et al. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol. 2004;5:934-42 pubmed
    ..These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found...
  71. Kunz S, Borrow P, Oldstone M. Receptor structure, binding, and cell entry of arenaviruses. Curr Top Microbiol Immunol. 2002;262:111-37 pubmed
  72. Charrel R, Coutard B, Baronti C, Canard B, Nougairede A, Frangeul A, et al. Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals. Antiviral Res. 2011;90:102-14 pubmed publisher
  73. Vela E, Knostman K, Mott J, Warren R, Garver J, Vela L, et al. Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model. Antiviral Res. 2010;87:318-28 pubmed publisher
    ..In all, the results from this study demonstrate the potential of a general kinase inhibitor genistein as an antiviral against arenaviral hemorrhagic fever...
  74. de Bellocq J, Borremans B, Katakweba A, Makundi R, Baird S, Becker Ziaja B, et al. Sympatric occurrence of 3 arenaviruses, Tanzania. Emerg Infect Dis. 2010;16:692-5 pubmed publisher
    ..We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA polymerase gene showed sympatric occurrence of 3 distinct arenaviruses...
  75. Palacios G, Savji N, Hui J, Travassos da Rosa A, Popov V, Briese T, et al. Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa. J Gen Virol. 2010;91:1315-24 pubmed publisher
    ..We propose MWV as a tentative novel species in the Lassa-lymphocytic choriomeningitis virus complex, based on its isolation from a novel rodent species and its genetic and serological characteristics...
  76. Djavani M, Crasta O, Zhang Y, Zapata J, Sobral B, Lechner M, et al. Gene expression in primate liver during viral hemorrhagic fever. Virol J. 2009;6:20 pubmed publisher
    ..In the present study, changes in liver gene expression from macaques infected with virulent LCMV-WE were compared to gene expression in uninfected monkeys as well as to monkeys that were infected but not diseased...
  77. Brooks D, Lee A, Elsaesser H, McGavern D, Oldstone M. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med. 2008;205:533-41 pubmed publisher
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  78. Bowick G, Fennewald S, Scott E, Zhang L, Elsom B, Aronson J, et al. Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics. J Virol. 2007;81:1923-33 pubmed
    ..We believe that these nodes provide potential targets for the development of antiviral therapies by acting at the level of the host response rather than by directly targeting viral proteins...
  79. Charrel R, de Lamballerie X. Arenaviruses other than Lassa virus. Antiviral Res. 2003;57:89-100 pubmed
  80. Borio L, Inglesby T, Peters C, Schmaljohn A, Hughes J, Jahrling P, et al. Hemorrhagic fever viruses as biological weapons: medical and public health management. JAMA. 2002;287:2391-405 pubmed
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  81. Teijaro J, Ng C, Lee A, Sullivan B, Sheehan K, Welch M, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science. 2013;340:207-11 pubmed publisher
    ..Our results suggest that therapies targeting IFN-I may help control persistent virus infections...