infectious myxomatosis

Summary

Publications

  1. Possible interaction between myxomatosis and calicivirosis related to rabbit haemorrhagic disease affecting the European rabbit
    S Marchandeau
    Office National de la Chasse et de la Faune Sauvage, Direction des Etudes et de la Recherche, 53 rue Russeil, 44000 Nantes, France
    Vet Rec 155:589-92
  2. The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes
    M Barry
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Virology 239:360-77
  3. Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins
    Jean Luc Guerin
    UMR 960 Microbiologie Moléculaire, Institut National de la Recherche Agronomique and Ecole Nationale Vétérinaire, 31076 Toulouse, France
    J Virol 76:2912-23
  4. Sequence mapping of the Californian MSW strain of Myxoma virus
    A Labudovic
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia
    Arch Virol 149:553-70
  5. Mutation of the Myxoma virus SERP2 P1-site to prevent proteinase inhibition causes apoptosis in cultured RK-13 cells and attenuates disease in rabbits, but mutation to alter specificity causes apoptosis without reducing virulence
    Amy L MacNeill
    University of Illinois College of Veterinary Medicine, Department of Pathobiology, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Virology 356:12-22
  6. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis
    J C Merchant
    CSIRO Sustainable Ecosystems and Pest Animal Control Cooperative Research Centre, GPO Box 284, Canberra, ACT 2601, Australia
    Epidemiol Infect 130:113-21
  7. Immune responses to myxoma virus
    Peter Kerr
    Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT, Australia
    Viral Immunol 15:229-46
  8. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. III. Release, persistence and rate of spread of an identifiable strain of myxoma virus
    J C Merchant
    CSIRO Sustainable Ecosystems and Vertebrate Biocontrol Cooperative Research Centre, PO Box 284 Canberra, ACT 2601, Australia
    Epidemiol Infect 130:135-47
  9. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. II. Selection of a strain of virus for release
    P J Kerr
    CSIRO Sustainable Ecosystems and Pest Animal Control Cooperative Research Centre, GPO Box 284, Canberra, ACT, 2601, Australia
    Epidemiol Infect 130:123-33
  10. Atypical myxomatosis--virus isolation, experimental infection of rabbits and restriction endonuclease analysis of the isolate
    I Psikal
    Veterinary Research Institute, Hudcova, Brno, Czech Republic
    J Vet Med B Infect Dis Vet Public Health 50:259-64

Scientific Experts

  • P J Kerr
  • Martha C Zúñiga
  • Yoav Turgeman
  • David Fouchet
  • Isabella M Cattadori
  • Amy L MacNeill
  • I Psikal
  • Joanne Lello
  • Jean-Sébastien Guitton
  • John W Barrett
  • C Calvete
  • J C Merchant
  • Grant McFadden
  • C R Carmo
  • Edita Jeklova
  • J Abrantes
  • P J Esteves
  • Marianne M Stanford
  • Xiujuan Gao
  • Steven J Werden
  • Zhuhong Shao
  • W van der Loo
  • Nicolas Collin
  • S Marchandeau
  • A Labudovic
  • Nalini Gupta
  • Jacqueline Gelfi
  • Gerd Sutter
  • Ingo Drexler
  • N G Simms
  • J Lucientes
  • Adrian Boswood
  • A Farsang
  • Martin B Van Der Weyden
  • A J Robinson
  • R Estrada
  • Janet Patterson-Kane
  • R Villafuerte
  • Jean Luc Guerin
  • Zora Nevorankova
  • Kamil Kovarcik
  • G Thompson
  • Jan Matiasovic
  • Lenka Leva
  • Hana Kudlackova
  • Martin Faldyna
  • Joanna Sypula
  • Tara A Belsito
  • Gen Wang
  • Timothy S Irvine
  • Lindsay R Alston
  • Catherine Barrett
  • Chew Shun Chang
  • Danielle Villenevue
  • Fuan Wang
  • N Ferrand
  • Gilles Foucras
  • J J Osacar
  • B Peralta
  • Sumitra Dash
  • Reena Das
  • Vijay Kumar
  • J Letty
  • H Perkins
  • B van Leeuwen
  • C Boucraut-Baralon
  • Jasmina Ahluwalia
  • M Barry
  • C Boucraut Baralon
  • S Bertagnoli
  • Neelam Varma
  • Gurjeevan Garewal
  • F Reitz
  • Anne French
  • G M Hood
  • Simon Swift
  • Mark Patteson
  • Chris Little
  • L Makranszki
  • R P Pech
  • Jo Dukes McEwan
  • L Kucsera
  • Sarah Smith
  • Jean-Luc Guerin
  • Frederique Anne Bellanger
  • Maxence Delverdier
  • Frederique Messud-Petit
  • Stephane Bertagnoli
  • Severine Boullier
  • Frederique-Anne Bellanger
  • Frederique Messud Petit
  • S F Lee
  • K Mossman
  • L Boshkov
  • S Hnatiuk
  • G McFadden

Detail Information

Publications33

  1. Possible interaction between myxomatosis and calicivirosis related to rabbit haemorrhagic disease affecting the European rabbit
    S Marchandeau
    Office National de la Chasse et de la Faune Sauvage, Direction des Etudes et de la Recherche, 53 rue Russeil, 44000 Nantes, France
    Vet Rec 155:589-92
    ..1 and 8.4 times higher than the odds of a rabbit being seronegative to myxoma virus and seropositive to RHD. The year and bodyweight had significant effects for myxomatosis in one area and for RHD in both areas...
  2. The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes
    M Barry
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Virology 239:360-77
    ..Our results indicate that M-T4 is the first example of an intracellular virulence factor in myxoma virus that functions from within the endoplasmic reticulum and is necessary for the productive infection of lymphocytes...
  3. Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins
    Jean Luc Guerin
    UMR 960 Microbiologie Moléculaire, Institut National de la Recherche Agronomique and Ecole Nationale Vétérinaire, 31076 Toulouse, France
    J Virol 76:2912-23
    ..The down-regulation of cell surface molecules by scrapins probably helps protect infected cells during viral infections...
  4. Sequence mapping of the Californian MSW strain of Myxoma virus
    A Labudovic
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia
    Arch Virol 149:553-70
    ..Three known virulence genes, including the serine proteinase inhibitor (SERPIN) genes M151R and M152R and leukemia associated protein (LAP) gene M153R, and the potential virulence gene M156R are now present in two copies...
  5. Mutation of the Myxoma virus SERP2 P1-site to prevent proteinase inhibition causes apoptosis in cultured RK-13 cells and attenuates disease in rabbits, but mutation to alter specificity causes apoptosis without reducing virulence
    Amy L MacNeill
    University of Illinois College of Veterinary Medicine, Department of Pathobiology, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Virology 356:12-22
    ..Control of apoptosis in culture does not correlate with virulence in rabbits. Virulence may instead depend on inhibition of proinflammatory proteinases by SERP2...
  6. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis
    J C Merchant
    CSIRO Sustainable Ecosystems and Pest Animal Control Cooperative Research Centre, GPO Box 284, Canberra, ACT 2601, Australia
    Epidemiol Infect 130:113-21
    ..It was concluded that mid to late spring was an optimal time for a deliberate release...
  7. Immune responses to myxoma virus
    Peter Kerr
    Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT, Australia
    Viral Immunol 15:229-46
    ....
  8. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. III. Release, persistence and rate of spread of an identifiable strain of myxoma virus
    J C Merchant
    CSIRO Sustainable Ecosystems and Vertebrate Biocontrol Cooperative Research Centre, PO Box 284 Canberra, ACT 2601, Australia
    Epidemiol Infect 130:135-47
    ..Using three different methods of calculation, rates of spread ranged from 3.7 to 17.8 m d(-1)...
  9. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. II. Selection of a strain of virus for release
    P J Kerr
    CSIRO Sustainable Ecosystems and Pest Animal Control Cooperative Research Centre, GPO Box 284, Canberra, ACT, 2601, Australia
    Epidemiol Infect 130:123-33
    ..Most of the virus strains tested induced very small or invisible primary lesions at the inoculation site. Thus the secondary skin sites such as eyelids, face and ears may be critical for transmission...
  10. Atypical myxomatosis--virus isolation, experimental infection of rabbits and restriction endonuclease analysis of the isolate
    I Psikal
    Veterinary Research Institute, Hudcova, Brno, Czech Republic
    J Vet Med B Infect Dis Vet Public Health 50:259-64
    ....
  11. The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules
    Nicolas Collin
    UMR 1225 Interactions Hôtes Agents Pathogènes, INRA ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, BP87614, 31076 Toulouse cedex 03, France
    Virology 343:171-8
    ..Our data suggest that the functionality of viral LAP factors, inherited by herpes- and poxviruses from mammalian cells, is more complex than anticipated...
  12. M135R is a novel cell surface virulence factor of myxoma virus
    John W Barrett
    BioTherapeutics Research Group, Robarts Research Institute and Department of Microbiology and Immunology, University of Western Ontario, 1400 Western Road, Room 126, London, ON N6G 2V4, Canada
    J Virol 81:106-14
    ..We propose that M135R is an important immunomodulatory virulence factor for myxomatosis but that the target immune ligand is not from the predicted type I interferon family and remains to be identified...
  13. Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells
    John W Barrett
    The BioTherapeutics Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6G 2V4
    Virology 361:123-32
    ..Altogether, these observations demonstrate that M063R plays a critical role in determining the host specificity of myxoma virus in rabbit cells...
  14. Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis
    P J Kerr
    Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT, 2601, Australia
    Virology 324:117-28
    ..Expression of IL-4 did not overcome immunity to myxomatosis induced by immunization...
  15. Occurrence of atypical myxomatosis in Central Europe: clinical and virological examinations
    A Farsang
    Institute for Veterinary Medicinal Products, H 1475 Budapest, PO Box 318, Hungary
    Acta Vet Hung 51:493-501
    ..This is the first report on atypical myxomatosis in Central Europe. The virus spreads by airborne transmission and may cause severe losses in the rabbit population...
  16. Genetic characterization of the chemokine receptor CXCR4 gene in lagomorphs: comparison between the families Ochotonidae and Leporidae
    J Abrantes
    CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal
    Int J Immunogenet 35:111-7
    ..Furthermore, in the 37 European rabbits analysed, which included healthy rabbits and rabbits with clinical symptoms of myxomatosis, 14 nucleotide substitutions were obtained but no amino acid differences were observed...
  17. Characterisation of immunosuppression in rabbits after infection with myxoma virus
    Edita Jeklova
    Department of Immunology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Vet Microbiol 129:117-30
    ..Presence of MXV in respective lymphoid compartments preceded changes in lymphocyte subset distribution or lymphocyte activity...
  18. The effect of single and concomitant pathogen infections on condition and fecundity of the wild rabbit (Oryctolagus cuniculus)
    J Lello
    CSIRO Livestock Industries, FD McMaster Laboratories Chiswick, Locked Bag 1, PO Armidale, Armidale DC, NSW 2350, Australia
    Int J Parasitol 35:1509-15
    ..Increasing host body mass was positively associated with number of foetuses and we propose that mass reduction caused by the pathogen and parasite species could also have the consequence of reducing foetal number...
  19. Parasite co-infection and interaction as drivers of host heterogeneity
    I M Cattadori
    Division of Animal Production and Public Health, Faculty of Veterinary Medicine, The University of Glasgow, Glasgow G61 1QH, UK
    Int J Parasitol 38:371-80
    ..strigosum which does not produce any evident immune reaction. We concluded that concomitant infections mediated by host immunity are important in modifying host susceptibility and influencing heterogeneity amongst individual hosts...
  20. Myxoma virus in the European rabbit: interactions between the virus and its susceptible host
    Marianne M Stanford
    BioTherapeutics Research Group, Robarts Research Institute, University of Western Ontario, Siebens Drake Building, Room 126, 1400 Western Road, London, Ontario, N6G 2V4, Canada
    Vet Res 38:299-318
    ..This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts...
  21. Study of localised dermatosis in rabbits caused by myxomatosis
    Janet Patterson-Kane
    Vet Rec 152:308
  22. Effects of vaccination against viral haemorrhagic disease and myxomatosis on long-term mortality rates of European wild rabbits
    C Calvete
    Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, C Miguel Servet 177, 50013 Zaragoza, Spain
    Vet Rec 155:388-92
    ..Compared with adult rabbits with natural antibodies to VHD, rabbits without these antibodies were 5.2 times more likely to die of VHD during annual outbreaks...
  23. Epidemiology of viral haemorrhagic disease and myxomatosis in a free-living population of wild rabbits
    C Calvete
    Instituto de Investigación de Recursos Cinégeticos, Ciudad Real, Spain
    Vet Rec 150:776-82
    ..The annual mean mortality rate due to VHD in adult rabbits was estimated to be 21.8 per cent...
  24. Genetic variation at chemokine receptor CCR5 in leporids: alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus, but not in Sylvilagus and Lepus species
    C R Carmo
    Departamento de Zoologia e Antropologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal
    Immunogenetics 58:494-501
    ..cuniculus algirus and O. cuniculus cuniculus. Allelic variation at the rabbit CCR5 locus confirmed that the gene conversion predates the subspecies split (1-2 Ma)...
  25. Impact of myxomatosis in relation to local persistence in wild rabbit populations: the role of waning immunity and the reproductive period
    David Fouchet
    UMR CNRS 5558 Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon1, 43 Boul 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    J Theor Biol 250:593-605
    ....
  26. Waning of maternal immunity and the impact of diseases: the example of myxomatosis in natural rabbit populations
    D Fouchet
    UMR CNRS 5558, Biométrie et Biologie Evolutive, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    J Theor Biol 242:81-9
    ..As a consequence, waning of acquired immunity and the continuous supply of newborn along the year may reduce the impact of the disease...
  27. Severe mitral stenosis after Duran ring implantation for myxomatous mitral regurgitation
    Yoav Turgeman
    Department of Cardiology, Haemek Medical Center, Afula, Israel
    Isr Med Assoc J 7:344-5
  28. Researchers as guinea pigs
    Martin B Van Der Weyden
    Med J Aust 178:52-3
  29. Investigation of pimobendan versus benazepril in canine myxomatous valvular disease
    Adrian Boswood
    Vet Rec 153:439-40
  30. Myxomatous stromal changes and necrosis of bone marrow--a retrospective study of 3 years
    Nalini Gupta
    Department of Hematology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh
    Indian J Pathol Microbiol 47:351-3
    ..There is paucity of such associations in the literature...