epidermodysplasia verruciformis

Summary

Summary: An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales.

Top Publications

  1. Ramoz N, Rueda L, Bouadjar B, Favre M, Orth G. A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus. J Invest Dermatol. 1999;112:259-63 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by an abnormal susceptibility to infection with a specific group of related human papillomavirus (HPV) genotypes, including the oncogenic HPV5 associated with ..
  2. Harwood C, Surentheran T, Sasieni P, Proby C, Bordea C, Leigh I, et al. Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol. 2004;150:949-57 pubmed
    Human papillomaviruses (HPVs) are found in normal skin and in benign and malignant skin conditions. Epidermodysplasia verruciformis (EV) HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin.
  3. Gul U, Kilic A, Gonul M, Cakmak S, Bayis S. Clinical aspects of epidermodysplasia verruciformis and review of the literature. Int J Dermatol. 2007;46:1069-72 pubmed
    b>Epidermodysplasia verruciformis (EV), is an unusual genodermatosis characterized by persistent human papilloma virus infection with an autosomal recessive inheritance pattern...
  4. Zuo Y, Ma D, Zhang Y, Qiao J, Wang B. Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis. J Dermatol Sci. 2006;44:153-9 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disease. The main clinical features include three kinds of lesions, high risk of skin cancer, and abnormal susceptibility to HPV 5 and 8...
  5. Alpsoy E, Ciftcioglu M, Keser I, de Villiers E, Zouboulis C. Epidermodysplasia verruciformis associated with neurofibromatosis type 1: coincidental association or model for understanding the underlying mechanism of the disease?. Br J Dermatol. 2002;146:503-7 pubmed
    We describe a 25-year-old man with epidermodysplasia verruciformis (EV) associated with neurofibromatosis type 1 (NF1)...
  6. Pfister H, Fuchs P, Majewski S, Jablonska S, Pniewska I, Malejczyk M. High prevalence of epidermodysplasia verruciformis-associated human papillomavirus DNA in actinic keratoses of the immunocompetent population. Arch Dermatol Res. 2003;295:273-9 pubmed
    Skin cancers in both immunosuppressed and immunocompetent populations are associated with epidermodysplasia verruciformis human papillomavirus (EV-HPV) DNA...
  7. Tate G, Suzuki T, Kishimoto K, Mitsuya T. Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. J Hum Genet. 2004;49:223-5 pubmed
    Germline mutations of the EVER1/TMC6 gene are associated with epidermodysplasia verruciformis (EV), which is characterized by an abnormal susceptibility to human papillomaviruses that were considered to be innocuous for the general ..
  8. Tobin E, Rohwedder A, Holland S, Philips B, Carlson J. Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia. Br J Dermatol. 2003;149:627-33 pubmed
    ..polymerase chain reaction analysis for HPV DNA revealed that the abscess-related cyst walls harboured epidermodysplasia verruciformis (EV)-associated HPV types 20, 24, alb-7 (AY013872) and 80...
  9. García Río I, García F Villalta M, Daudén E, Fraga J, Garcia Diez A. Epidermodysplasia verruciformis-like lesions in a patient with systemic lupus erythematosus. Acta Derm Venereol. 2003;83:229-30 pubmed

More Information

Publications62

  1. Aghaei S, Aslani F. Systemic lupus erythematosus arising in a patient with epidermodysplasia verruciformis. Lupus. 2006;15:47-50 pubmed
    Few cases have been published relating systemic lupus erythematosus (SLE) and epidermodysplasia verruciformis (EV). We describe a patient with this association...
  2. Boxman I, Russell A, Mulder L, Bavinck J, ter Schegget J, Green A. Association between epidermodysplasia verruciformis-associated human papillomavirus DNA in plucked eyebrow hair and solar keratoses. J Invest Dermatol. 2001;117:1108-12 pubmed
  3. Sun X, Chen J, Xu A. A homozygous nonsense mutation in the EVER2 gene leads to epidermodysplasia verruciformis. Clin Exp Dermatol. 2005;30:573-4 pubmed
    b>Epidermodysplasia verruciformis (EV) is a genodermatosis with mainly autosomal recessive inheritance. Pathogenic mutations in two adjacent genes, EVER1 and EVER2, have recently been identified...
  4. Orth G. Human papillomaviruses associated with epidermodysplasia verruciformis in non-melanoma skin cancers: guilty or innocent?. J Invest Dermatol. 2005;125:xii-xiii pubmed
  5. Laffort C, Le Deist F, Favre M, Caillat Zucman S, Radford Weiss I, Debre M, et al. Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gammac cytokine receptor subunit or JAK-3 deficiency. Lancet. 2004;363:2051-4 pubmed
    ..Four had lesions typical of epidermodysplasia verruciformis, a rare genodermatosis...
  6. Gewirtzman A, Bartlett B, Tyring S. Epidermodysplasia verruciformis and human papilloma virus. Curr Opin Infect Dis. 2008;21:141-6 pubmed publisher
    Despite its rarity, epidermodysplasia verruciformis was addressed in depth in recent literature...
  7. Dell Oste V, Azzimonti B, de Andrea M, Mondini M, Zavattaro E, Leigheb G, et al. High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis. J Invest Dermatol. 2009;129:1026-34 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a rare disease, characterized by cutaneous warts and associated with a strong predisposition to beta-genus human papillomavirus (HPV)...
  8. Majewski S, Jablonska S. Do epidermodysplasia verruciformis human papillomaviruses contribute to malignant and benign epidermal proliferations?. Arch Dermatol. 2002;138:649-54 pubmed
    The aim of this review is to present new data on epidermodysplasia verruciformis (EV) and EV human papillomaviruses (HPVs), regarded previously as specific to the disease...
  9. Anadolu R, Oskay T, Erdem C, Boyvat A, Terzi E, Gurgey E. Treatment of epidermodysplasia verruciformis with a combination of acitretin and interferon alfa-2a. J Am Acad Dermatol. 2001;45:296-9 pubmed
    b>Epidermodysplasia verruciformis (EV) is an autosomal recessive disease characterized by the lifelong eruption of disseminated verrucae-like lesions. Numerous treatment modalities have been used to treat EV without benefit...
  10. Lazarczyk M, Pons C, Mendoza J, Cassonnet P, Jacob Y, Favre M. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med. 2008;205:35-42 pubmed
    b>Epidermodysplasia verruciformis (EV) is a genodermatosis associated with skin cancers that results from a selective susceptibility to related human papillomaviruses (EV HPV)...
  11. Davison S, Francis N, McLean K, Bunker C. Epidermodysplasia verruciformis-like eruption associated with HIV infection. Clin Exp Dermatol. 2004;29:311-2 pubmed
  12. Ateenyi Agaba C, Weiderpass E, Smet A, Dong W, Dai M, Kahwa B, et al. Epidermodysplasia verruciformis human papillomavirus types and carcinoma of the conjunctiva: a pilot study. Br J Cancer. 2004;90:1777-9 pubmed
    ..b>Epidermodysplasia verruciformis HPV types were found in 86% of SCC cases and 36% of control subjects (Odds ratio=12...
  13. Jacobelli S, Laude H, Carlotti A, Rozenberg F, Deleuze J, Morini J, et al. Epidermodysplasia verruciformis in human immunodeficiency virus-infected patients: a marker of human papillomavirus-related disorders not affected by antiretroviral therapy. Arch Dermatol. 2011;147:590-6 pubmed publisher
    Skin eruptions resembling epidermodysplasia verruciformis (EV) are rarely observed in immunocompromised patients...
  14. Lowe S, Katsidzira L, Meys R, Sterling J, de Koning M, Quint W, et al. Acquired epidermodysplasia verruciformis due to multiple and unusual HPV infection among vertically-infected, HIV-positive adolescents in Zimbabwe. Clin Infect Dis. 2012;54:e119-23 pubmed publisher
    We have previously described the presentation of epidermodysplasia verruciformis (EV)-like eruptions in almost a quarter of hospitalized adolescents with vertically-acquired human immunodeficiency virus (HIV) infection in Harare, ..
  15. Feltkamp M, Broer R, di Summa F, Struijk L, van der Meijden E, Verlaan B, et al. Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer. Cancer Res. 2003;63:2695-700 pubmed
    DNA from epidermodysplasia verruciformis-related human papillomavirus (EV-HPV) types is frequently found in nonmelanoma skin cancer (squamous and basal cell carcinoma)...
  16. Micali G, Nasca M, Dall Oglio F, Musumeci M. Cimetidine therapy for epidermodysplasia verruciformis. J Am Acad Dermatol. 2003;48:S9-10 pubmed
    ..of clinical features, histologic examination of 2 lesions and positivity for HPV 5, a diagnosis of epidermodysplasia verruciformis was made...
  17. Berger T, Sawchuk W, Leonardi C, Langenberg A, Tappero J, LeBoit P. Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease. Br J Dermatol. 1991;124:79-83 pubmed
    ..cytoplasm in granular layer keratinocytes, characteristic of the human papillomavirus types seen in epidermodysplasia verruciformis. DNA hybridization techniques demonstrated the presence of HPV-type 8 in one patient and HPV 5 and 8 ..
  18. Sá N, Guerini M, Barbato M, Di Giunta G, Nunes D. Epidermodysplasia verruciformis: clinical presentation with varied forms of lesions. An Bras Dermatol. 2011;86:S57-60 pubmed
    b>Epidermodysplasia verruciformis is a rare inherited skin disorder spread by HPV, with cases linked to chromosome X...
  19. Favre M, Obalek S, Jablonska S, Orth G. Human papillomavirus (HPV) type 50, a type associated with epidermodysplasia verruciformis (EV) and only weakly related to other EV-specific HPVs. J Virol. 1989;63:4910 pubmed
    ..Alignment of the genomic map with that of human papillomavirus type 5, with which it is only weakly related, was permitted by partial DNA sequence analysis...
  20. Patel T, Morrison L, Rady P, Tyring S. Epidermodysplasia verruciformis and susceptibility to HPV. Dis Markers. 2010;29:199-206 pubmed publisher
    b>Epidermodysplasia verruciformis has been addressed in depth in the recent literature despite its rarity...
  21. Hayashi J, Matsui C, Mitsuishi T, Kawashima M, Morohashi M. Treatment of localized epidermodysplasia verruciformis with tacalcitol ointment. Int J Dermatol. 2002;41:817-20 pubmed
  22. Hoffner M, Camacho F. Surgical treatment of epidermodysplasia verruciformis. Dermatol Surg. 2010;36:363-7 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients.
  23. Bouwes Bavinck J, Stark S, Petridis A, Marugg M, ter Schegget J, Westendorp R, et al. The presence of antibodies against virus-like particles of epidermodysplasia verruciformis-associated humanpapillomavirus type 8 in patients with actinic keratoses. Br J Dermatol. 2000;142:103-9 pubmed
    b>Epidermodysplasia verruciformis-associated human papillomaviruses (EV-HPVs) are possibly involved in the development of actinic keratoses and may play a part in the pathogenesis of squamous cell carcinoma (SCC) of the skin, as the DNA of ..
  24. Gubinelli E, Posteraro P, Cocuroccia B, Girolomoni G. Epidermodysplasia verruciformis with multiple mucosal carcinomas treated with pegylated interferon alfa and acitretin. J Dermatolog Treat. 2003;14:184-8 pubmed
    b>Epidermodysplasia verruciformis (EV) is characterized by abnormal genetically-determined susceptibility to widespread and persistent infection of the skin with human papillomaviruses (HPV)...
  25. Arnold A, Burger B, Kump E, Rufle A, Tyring S, Kempf W, et al. Homozygosity for the c.917A?T (p.N306l) polymorphism in the EVER2/TMC8 gene of two sisters with epidermodysplasia verruciformis Lewandowsky-Lutz originally described by Wilhelm Lutz. Dermatology. 2011;222:81-6 pubmed publisher
    b>Epidermodysplasia verruciformis Lewandowsky-Lutz (EV) is a rare genodermatosis, characterised by development of numerous verrucous skin lesions caused by specific genotypes of human papillomaviruses belonging to the ?-papillomavirus ..
  26. Rogers H, MacGregor J, Nord K, Tyring S, Rady P, Engler D, et al. Acquired epidermodysplasia verruciformis. J Am Acad Dermatol. 2009;60:315-20 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes...
  27. Bonamigo R, Maldonado G, Londero R, Cartell A. Epidermodysplasia verruciformis-like disorder in a teenager with HIV and HCV infections. Pediatr Dermatol. 2007;24:456-7 pubmed
  28. Gober M, Rady P, He Q, Tucker S, Tyring S, Gaspari A. Novel homozygous frameshift mutation of EVER1 gene in an epidermodysplasia verruciformis patient. J Invest Dermatol. 2007;127:817-20 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare genetic skin disease with an autosomal recessive trait, and the patients have susceptibility to a specific group of human papillomavirus genotypes...
  29. Majewski S, Jablonska S. Possible involvement of epidermodysplasia verruciformis human papillomaviruses in the immunopathogenesis of psoriasis: a proposed hypothesis. Exp Dermatol. 2003;12:721-8 pubmed
    ..More recently, EV genes were identified, EVER1 and EVER2, whose mutations are responsible for epidermodysplasia verruciformis. Eidermodysplasia verruciforms-associated human papillomaviruses are harmless to the general ..
  30. de Oliveira W, Rady P, Grady J, Hughes T, Festa Neto C, Rivitti E, et al. Polymorphisms of the interleukin 10 gene promoter in patients from Brazil with epidermodysplasia verruciformis. J Am Acad Dermatol. 2003;49:639-43 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by development of lesions associated with human papillomavirus in early childhood and malignant transformation in approximately half of individuals during ..
  31. Orth G. Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses. Semin Immunol. 2006;18:362-74 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma...
  32. Ramoz N, Rueda L, Bouadjar B, Montoya L, Orth G, Favre M. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet. 2002;32:579-81 pubmed
    b>Epidermodysplasia verruciformis (OMIM 226400) is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses (HPVs)...
  33. Akgul B, Cooke J, Storey A. HPV-associated skin disease. J Pathol. 2006;208:165-75 pubmed
    ..This review summarizes the literature describing these data, highlights some of the important findings derived from these studies, and speculates on future perspectives...
  34. Heratizadeh A, Volker B, Kupsch E, Wichmann K, Kapp A, Werfel T. [Successful symptomatic treatment of epidermodysplasia verruciformis with imiquimod 5% cream]. Hautarzt. 2010;61:1052-5 pubmed publisher
    A 19-year-old patient presented with epidermodysplasia verruciformis (EV)...
  35. Azzimonti B, Mondini M, de Andrea M, Gioia D, Dianzani U, Mesturini R, et al. CD8+ T-cell lymphocytopenia and lack of EVER mutations in a patient with clinically and virologically typical epidermodysplasia verruciformis. Arch Dermatol. 2005;141:1323-5 pubmed
  36. Barcelos A, Sotto M. Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions. J Cutan Pathol. 2009;36:647-54 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to human papillomavirus (HPV) infection, and high risk of skin cancer considered a model of viral oncogenesis.
  37. Berk D, Bruckner A, Lu D. Epidermodysplasia verruciform-like Lesions in an HIV patient. Dermatol Online J. 2009;15:1 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare disorder involving widespread infection with specific human papillomavirus types and characteristic clinical lesions that may resemble verruca plana, tinea versicolor, psoriasis, or ..
  38. Stetsenko G, McFarlane R, Chien A, Fleckman P, Swanson P, George E, et al. Subungual Bowen disease in a patient with epidermodysplasia verruciformis presenting clinically as longitudinal melanonychia. Am J Dermatopathol. 2008;30:582-5 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a rare autosomal-recessive condition associated with a predisposition to infection with specific types of human papillomaviruses...
  39. Boxman I, Russell A, Mulder L, Bavinck J, Schegget J, Green A. Case-control study in a subtropical Australian population to assess the relation between non-melanoma skin cancer and epidermodysplasia verruciformis human papillomavirus DNA in plucked eyebrow hairs. The Nambour Skin Cancer Prevention Study Group. Int J Cancer. 2000;86:118-21 pubmed
    b>Epidermodysplasia verruciformis human papillomavirus (EV-HPV) DNA has been demonstrated in malignant and benign skin lesions and in hairs plucked from renal transplant recipients and immunocompetent patients...
  40. Padlewska K, Ramoz N, Cassonnet P, Riou G, Barrois M, Majewski S, et al. Mutation and abnormal expression of the p53 gene in the viral skin carcinogenesis of epidermodysplasia verruciformis. J Invest Dermatol. 2001;117:935-42 pubmed
    Patients suffering from epidermodysplasia verruciformis are prone to nonmelanoma skin cancers, due to an inherited abnormal susceptibility to the oncogenic human papillomavirus type 5...
  41. Sehgal V, Luthra A, Bajaj P. Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation. Int J Dermatol. 2002;41:500-3 pubmed
    ..Hematoxylin and eosin-stained sections prepared from biopsies taken from representative lesions of epidermodysplasia verruciformis and squamous cell carcinoma revealed their diagnostic features...
  42. Berthelot C, Dickerson M, Rady P, He Q, Niroomand F, Tyring S, et al. Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod. J Am Acad Dermatol. 2007;56:882-6 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare disorder characterized by widespread human papillomavirus infection and malignant transformation...
  43. Hohenstein E, Rady P, Hergersberg M, Huber A, Tyring S, Bregenzer T, et al. Epidermodysplasia verruciformis in a HIV-positive patient homozygous for the c917A-->T polymorphism in the TMC8/EVER2 gene. Dermatology. 2009;218:114-8 pubmed publisher
    b>Epidermodysplasia verruciformis (EV) is a rare autosomal-recessive disorder characterized by widespread and persistent infection with human papilloma virus (HPV) and a risk of malignant degeneration...
  44. Orth G. Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis. Curr Top Microbiol Immunol. 2008;321:59-83 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare, autosomal recessive genodermatosis associated with a high risk of skin carcinoma (MIM 226400)...
  45. Ramoz N, Taieb A, Rueda L, Montoya L, Bouadjar B, Favre M, et al. Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. J Invest Dermatol. 2000;114:1148-53 pubmed
    b>Epidermodysplasia verruciformis is a rare genodermatosis associated with a high risk of skin cancer...
  46. Robati R, Marefat A, Saeedi M, Rahmati Roodsari M, Asadi Kani Z. Four familial cases of epidermodysplasia verruciformis: mother and three sons. Dermatol Online J. 2009;15:8 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer. In this report, we present three Iranian brothers and their mother with extensive seborrheic keratosis-like (SK-like) viral warts...
  47. Aochi S, Nakanishi G, Suzuki N, Setsu N, Suzuki D, Aya K, et al. A novel homozygous mutation of the EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. Br J Dermatol. 2007;157:1265-6 pubmed
  48. McDermott D, Gammon B, Snijders P, Mbata I, Phifer B, Howland Hartley A, et al. Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation. Pediatr Dermatol. 2009;26:306-10 pubmed publisher
    b>Epidermodysplasia verruciformis is a rare genodermatosis characterized by abnormal susceptibility to infection with specific human papillomavirus serotypes...
  49. Roncalli de Oliveira W, Neto C, Rady P, Tyring S. Seborrheic Keratosis-like lesions in patients with epidermodysplasia verruciformis. J Dermatol. 2003;30:48-53 pubmed
    b>Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by disseminated infection by human papillomavirus (HPV) and malignant transformation of the lesions in about half of the patients...
  50. Termorshuizen F, Feltkamp M, Struijk L, de Gruijl F, Bavinck J, Van Loveren H. Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus. J Invest Dermatol. 2004;122:1456-62 pubmed
    ..In addition, human papilloma virus (HPV), especially the epidermodysplasia verruciformis (EV)-associated types, may be involved...
  51. Kurima K, Yang Y, Sorber K, Griffith A. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Genomics. 2003;82:300-8 pubmed
    ..TMC6 and TMC8 are identical to the EVER1 and EVER2 genes implicated in epidermodysplasia verruciformis, a recessive disorder comprising susceptibility to cutaneous human papilloma virus infections and ..
  52. Rady P, de Oliveira W, He Q, Festa C, Rivitti E, Tucker S, et al. Novel homozygous nonsense TMC8 mutation detected in patients with epidermodysplasia verruciformis from a Brazilian family. Br J Dermatol. 2007;157:831-3 pubmed
  53. Borgogna C, Zavattaro E, de Andrea M, Griffin H, Dell Oste V, Azzimonti B, et al. Characterization of beta papillomavirus E4 expression in tumours from Epidermodysplasia Verruciformis patients and in experimental models. Virology. 2012;423:195-204 pubmed publisher
    ..The loss of such staining at the tumour border suggests a distinct type of E4 dysregulation that may be exploited as a marker of viral expression during ?-HPV-associated skin cancer progression...