roseolovirus infections

Summary

Summary: Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.

Top Publications

  1. Tokushima Imayoshi M, Onoue T, Matsuo M, Yoshida N, Sato T, Kobayashi M, et al. Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection. Int J Hematol. 2006;84:151-3 pubmed
    ..Although autoimmune neutropenia of infancy is benign and self limiting, it must be emphasized that severe bacterial infection will be induced by concurrent viral infection in this specific disorder. ..
  2. Pellett P, Ablashi D, Ambros P, Agut H, Caserta M, Descamps V, et al. Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol. 2012;22:144-55 pubmed publisher
    ..Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease. ..
  3. Potenza L, Barozzi P, Masetti M, Pecorari M, Bresciani P, Gautheret Dejean A, et al. Prevalence of human herpesvirus-6 chromosomal integration (CIHHV-6) in Italian solid organ and allogeneic stem cell transplant patients. Am J Transplant. 2009;9:1690-7 pubmed publisher
    ..Pretransplantation screening of donors and recipients may further prevent the misdiagnosis of CIHHV-6. ..
  4. Breddemann A, Laer S, Schmidt K, Harjes M, Adam R, Ludwig A, et al. Case report: severe gastrointestinal inflammation and persistent HHV-6B infection in a paediatric cancer patient. Herpes. 2007;14:41-4 pubmed
    ..After unsuccessful therapy with ganciclovir and foscarnet, combined antiviral and anti-inflammatory treatment with cidofovir and prednisolone controlled the HHV-6 infection and enabled resolution of clinical symptoms. ..
  5. Fotheringham J, Donati D, Akhyani N, Fogdell Hahn A, Vortmeyer A, Heiss J, et al. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med. 2007;4:e180 pubmed
    ..Overall, we have now detected HHV-6B in 15 of 24 patients with mesial temporal sclerosis/MTLE, in contrast to zero of 14 with other syndromes. Our results suggest a potential etiology and pathogenic mechanism for MTLE. ..
  6. Lusso P. HHV-6 and the immune system: mechanisms of immunomodulation and viral escape. J Clin Virol. 2006;37 Suppl 1:S4-10 pubmed
    ..By modulating specific antiviral immune responses, HHV-6 can facilitate its own spread and persistence in vivo, as well as enhance the pathogenic effects of other agents, such as human immunodeficiency virus. ..
  7. Shintaku M, Kaneda D, Tada K, Katano H, Sata T. Human herpes virus 6 encephalomyelitis after bone marrow transplantation: report of an autopsy case. Neuropathology. 2010;30:50-5 pubmed publisher
    ..Demyelination was supposed to be involved in the pathogenesis of some of the lesions...
  8. Hymas W, Stevenson J, Taggart E, Hillyard D. Use of lyophilized standards for the calibration of a newly developed real time PCR assay for human herpes type six (HHV6) variants A and B. J Virol Methods. 2005;128:143-50 pubmed
    ..The use of lyophilized standards contributes substantially to the maintenance of reproducible testing over an extended period of time...
  9. Dharancy S, Crombe V, Copin M, Boleslawski E, Bocket L, Declerck N, et al. Fatal hemophagocytic syndrome related to human herpesvirus-6 reinfection following liver transplantation: a case report. Transplant Proc. 2008;40:3791-3 pubmed publisher
    ..This case suggests that this virus may be a serious and potentially life-threatening pathogen following LT...

More Information

Publications68

  1. Lee S, Brown R, Razonable R. Clinical significance of pretransplant chromosomally integrated human herpesvirus-6 in liver transplant recipients. Transplantation. 2011;92:224-9 pubmed publisher
    ..This study was aimed to determine the potential role of CIHHV-6 on the occurrence of other infections, allograft rejection, and outcomes after liver transplantation...
  2. Zerr D, Fann J, Breiger D, Boeckh M, Adler A, Xie H, et al. HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients. Blood. 2011;117:5243-9 pubmed publisher
    ..These data provide the basis to conduct a randomized clinical trial to determine whether prevention of HHV-6 reactivation will reduce neurocognitive morbidity in HCT recipients...
  3. Loutfy S, Fawzy M, El Wakil M, Moneer M. Presence of human herpes virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection. Virol J. 2010;7:287 pubmed publisher
    ..Therefore, this study investigated the frequency of HHV6, its impact on clinical manifestations of lymphoma and its possible association with risk for development of CMV infection in pediatric lymphoma patients...
  4. Broccolo F, Drago F, Paolino S, Cassina G, Gatto F, Fusetti L, et al. Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. J Clin Virol. 2009;46:43-6 pubmed publisher
    ..Little is known about the involvement of human herpesviruses 6 and 7 (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD)...
  5. Luppi M, Barozzi P, Bosco R, Vallerini D, Potenza L, Forghieri F, et al. Human herpesvirus 6 latency characterized by high viral load: chromosomal integration in many, but not all, cells. J Infect Dis. 2006;194:1020-1; author reply 1021-3 pubmed
  6. Donati D, Martinelli E, Cassiani Ingoni R, Ahlqvist J, Hou J, Major E, et al. Variant-specific tropism of human herpesvirus 6 in human astrocytes. J Virol. 2005;79:9439-48 pubmed
    ..Astrocytes may be an important reservoir for this virus in which differential tropism of HHV-6A and HHV-6B may be associated with different disease outcomes...
  7. Chevret L, Boutolleau D, Halimi Idri N, Branchereau S, Baujard C, Fabre M, et al. Human herpesvirus-6 infection: a prospective study evaluating HHV-6 DNA levels in liver from children with acute liver failure. J Med Virol. 2008;80:1051-7 pubmed publisher
    ..03). These results strongly support the hypothesis that HHV-6 may cause fulminant hepatic failure and acute decompensation of chronic liver disease in children. Nevertheless, a threshold viral load value still remains to be determined...
  8. Ljungman P, Singh N. Human herpesvirus-6 infection in solid organ and stem cell transplant recipients. J Clin Virol. 2006;37 Suppl 1:S87-91 pubmed
    ..No established therapy exists but both ganciclovir and foscarnet have been reported to have in vitro and in vivo efficacy against HHV-6...
  9. Ward K, Thiruchelvam A, Couto Parada X. Unexpected occasional persistence of high levels of HHV-6 DNA in sera: detection of variants A and B. J Med Virol. 2005;76:563-70 pubmed
    ..The significance of this newly described phenomenon in relation to diagnosis, clinical consequences and congenital infection are discussed...
  10. Chapenko S, Folkmane I, Ziedina I, Chistyakovs M, Rozentals R, Krumina A, et al. Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy. J Clin Virol. 2009;46:29-32 pubmed publisher
    ..The long-term effect of HHV-6 and HHV-7 infections on chronic allograft nephropathy (CAN) development after renal transplantation is uncertain...
  11. Pradeau K, Bordessoule D, Szelag J, Rolle F, Ferrat P, Le Meur Y, et al. A reverse transcription-nested PCR assay for HHV-6 mRNA early transcript detection after transplantation. J Virol Methods. 2006;134:41-7 pubmed
    ..Finally, U79/80 mRNA detection was correlated with clinical manifestations including leucopenia, skin rash, graft rejection or dysfunction and diarrhoea...
  12. Flamand L, Gravel A, Boutolleau D, Alvarez Lafuente R, Jacobson S, Malnati M, et al. Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol. 2008;46:2700-6 pubmed publisher
    ..To provide better homogeneity between the results from the different laboratories working on HHV-6, we propose that investigators interested in quantifying HHV-6 in clinical samples adopt one of these assays...
  13. Theodore W, Epstein L, Gaillard W, Shinnar S, Wainwright M, Jacobson S. Human herpes virus 6B: a possible role in epilepsy?. Epilepsia. 2008;49:1828-37 pubmed publisher
  14. Hubacek P, Virgili A, Ward K, Pohlreich D, Keslova P, Goldova B, et al. HHV-6 DNA throughout the tissues of two stem cell transplant patients with chromosomally integrated HHV-6 and fatal CMV pneumonitis. Br J Haematol. 2009;145:394-8 pubmed publisher
    ..In individuals with chromosomal integration, HHV-6 DNA is found in every tissue of recipient origin indicating inheritance through the germ line...
  15. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, et al. HHV-6A in syncytial giant-cell hepatitis. N Engl J Med. 2008;359:593-602 pubmed publisher
    ..Neither HHV-6B DNA nor late protein was identified in the same follow-up samples from the patient. Thus, HHV-6A may be a cause of syncytial giant-cell hepatitis...
  16. Yoshikawa T, Fujita A, Yagami A, Suzuki K, Matsunaga K, Ihira M, et al. Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome. J Clin Virol. 2006;37 Suppl 1:S92-6 pubmed
    ..However, mechanisms for viral reactivation and modification of the clinical features remain unclear...
  17. Garcia Montojo M, De Las Heras V, Dominguez Mozo M, Bartolome M, Garcia Martinez M, Arroyo R, et al. Human herpesvirus 6 and effectiveness of interferon ?1b in multiple sclerosis patients. Eur J Neurol. 2011;18:1027-35 pubmed publisher
    ..The objectives of this study were to evaluate the in vivo antiviral effect of IFN-beta-1b over HHV-6 and EBV and to analyze whether such effect could be involved in its effectiveness in MS...
  18. Thomasini R, Sampaio A, Bonon S, Boin I, Leonardi L, Leonardi M, et al. Detection and monitoring of human herpesvirus 7 in adult liver transplant patients: impact on clinical course and association with cytomegalovirus. Transplant Proc. 2007;39:1537-9 pubmed
    ..Further studies should be performed including HHV-6 to evaluate the relationship, among beta herpesviruses...
  19. Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol. 2007;30:173-87 pubmed
    ..The aim of this review is to provide a short update of the current knowledge on these viruses, and to suggest that the medical importance of Roseoloviruses should not be understimated...
  20. Vu T, Carrum G, Hutton G, Heslop H, Brenner M, Kamble R. Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;39:705-9 pubmed
    ..Given this high incidence of HHV-6 and the possibility of successful outcome with prompt treatment, a high index of suspicion of this disorder is required in recipients of monoclonal antibody supported allografts...
  21. Peppercorn A, Miller M, Fitzgerald D, Weber D, Groben P, Cairns B. High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases. J Burn Care Res. 2010;31:365-8 pubmed publisher
  22. Alvarez Lafuente R, Martinez A, Garcia Montojo M, Mas A, De Las Heras V, Dominguez Mozo M, et al. MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients. Eur J Neurol. 2010;17:129-35 pubmed publisher
  23. Fotheringham J, Akhyani N, Vortmeyer A, Donati D, Williams E, Oh U, et al. Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid. J Infect Dis. 2007;195:450-4 pubmed
    ..Astrocytic cells positive for viral antigen provided support for an HHV-6-specific tropism for hippocampal astrocytes. HHV-6 DNA in CSF and serum may not reflect the level of active viral infection in the brain after BMT...
  24. Hall C, Caserta M, Schnabel K, Shelley L, Marino A, Carnahan J, et al. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics. 2008;122:513-20 pubmed publisher
    ..We examined the frequency and characteristics of chromosomally integrated human herpesvirus 6 among congenitally infected children...
  25. Nastke M, Becerra A, Yin L, Dominguez Amorocho O, Gibson L, Stern L, et al. Human CD4+ T cell response to human herpesvirus 6. J Virol. 2012;86:4776-92 pubmed publisher
    ..These findings provide a window into the immune response to HHV-6 and provide a basis for tracking HHV-6 cellular immune responses...
  26. Prusty B, Böhme L, Bergmann B, Siegl C, Krause E, Mehlitz A, et al. Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection. PLoS ONE. 2012;7:e47427 pubmed publisher
  27. Boutolleau D, Duros C, Bonnafous P, Caïola D, Karras A, Castro N, et al. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol. 2006;35:257-63 pubmed
  28. Chiou C, Chung W, Hung S, Yang L, Hong H. Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection. J Am Acad Dermatol. 2006;54:S14-7 pubmed
    ..Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed...
  29. Chapenko S, Krumina A, Kozireva S, Nora Z, Sultanova A, Viksna L, et al. Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J Clin Virol. 2006;37 Suppl 1:S47-51 pubmed
    ..Human herpesvirus 6 (HHV-6) and 7 (HHV-7) have been suggested as possible triggering agents for chronic fatigue syndrome (CFS)...
  30. De Filippis L, Foglieni C, Silva S, Vescovi A, Lusso P, Malnati M. Differentiated human neural stem cells: a new ex vivo model to study HHV-6 infection of the central nervous system. J Clin Virol. 2006;37 Suppl 1:S27-32 pubmed
  31. Fujimaki K, Mori T, Kida A, Tanaka M, Kawai N, Matsushima T, et al. Human herpesvirus 6 meningoencephalitis in allogeneic hematopoietic stem cell transplant recipients. Int J Hematol. 2006;84:432-7 pubmed
    ..Careful assessment of the clinical findings and the brain may allow early and precise diagnosis of HHV-6 meningoencephalitis and contribute to improving its prognosis...
  32. Ljungman P, de la Camara R, Cordonnier C, Einsele H, Engelhard D, Reusser P, et al. Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant. 2008;42:227-40 pubmed publisher
    ..Works presented only as abstracts were used to a very limited extent. The quality of evidence and level of recommendation were graded according to the Center for Disease Control (CDC) criteria...
  33. Yamashita N, Morishima T. HHV-6 and seizures. Herpes. 2005;12:46-9 pubmed
    ..These HHV-6-associated CNS diseases due to virus reactivation can occur in both immunocompromised and immunocompetent hosts. This article summarizes HHV-6-associated seizures during childhood...
  34. Revest M, Minjolle S, Veyer D, Lagathu G, Michelet C, Colimon R. Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of positive results. J Clin Virol. 2011;51:20-4 pubmed publisher
    ..Clinical manifestations of human herpesvirus-6 (HHV-6) have not been clearly defined, and the role of HHV-6 in human disease remains to be fully elucidated...
  35. Mahrholdt H, Wagner A, Deluigi C, Kispert E, Hager S, Meinhardt G, et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation. 2006;114:1581-90 pubmed
    ..Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples...
  36. Arbuckle J, Medveczky M, Luka J, Hadley S, Luegmayr A, Ablashi D, et al. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci U S A. 2010;107:5563-8 pubmed publisher
  37. Hall C, Caserta M, Schnabel K, Shelley L, Carnahan J, Marino A, et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis. 2010;201:505-7 pubmed publisher
    ..This suggests the possibility that CI-HHV-6 replicates and may cause most, if not all, congenital HHV-6 infections...
  38. Clark D, Ward K. Importance of chromosomally integrated HHV-6A and -6B in the diagnosis of active HHV-6 infection. Herpes. 2008;15:28-32 pubmed
    ..Increasingly, the polymerase chain reaction (to detect viral nucleic acid) is used for diagnosis; therefore, it is important to exclude HHV-6 chromosomal integration before concluding that there is evidence of active HHV-6 infection...
  39. Boccara O, Lesage F, Regnault V, Lasne D, Dupic L, Bourdon Lanoy E, et al. Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. Br J Dermatol. 2009;161:181-3 pubmed publisher
    ..Transient severe protein S deficiencies have previously been reported in patients with nonbacterial PF, usually after varicella infection. This is the first documented case of PF after HHV6 infection...
  40. Ward K, Leong H, Thiruchelvam A, Atkinson C, Clark D. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. J Clin Microbiol. 2007;45:1298-304 pubmed
  41. Tavakoli N, Nattanmai S, Hull R, Fusco H, Dzigua L, Wang H, et al. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol. 2007;45:3972-8 pubmed
  42. Yao K, Honarmand S, Espinosa A, Akhyani N, Glaser C, Jacobson S. Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol. 2009;65:257-67 pubmed publisher
    ..More than 150 different viruses have been implicated in the pathogenesis of encephalitis; however, because of limitations with diagnostic testing, causative factors of more than half of the cases remain unknown...
  43. Martinez A, Alvarez Lafuente R, Mas A, Bartolome M, Garcia Montojo M, De las Heras V, et al. Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA. Hum Immunol. 2007;68:685-9 pubmed
    ..Besides, this report indicates that when patients are grouped based upon a well-defined molecular event, complex diseases may reveal themselves as being constituted by distinct entities in which some genes may have a strong influence...
  44. Yao K, Gagnon S, Akhyani N, Williams E, Fotheringham J, Frohman E, et al. Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PLoS ONE. 2008;3:e2028 pubmed publisher
    ..These results support the hypothesis that treatment with natalizumab may be associated with reduced immune surveillance resulting in reactivation of viruses associated with MS pathogenesis...
  45. Lautenschlager I, Razonable R. Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review. Transpl Int. 2012;25:493-502 pubmed publisher
    ..Treatment of HHV-6 is indicated in established end-organ disease such as encephalitis. Foscarnet, ganciclovir, and cidofovir have been used for treatment...
  46. Nora Krukle Z, Chapenko S, Logina I, Millers A, Platkajis A, Murovska M. Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis. Medicina (Kaunas). 2011;47:527-31 pubmed
    ..HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via activation of Th1 lymphocyte subsets. ..
  47. Härmä M, Hockerstedt K, Lyytikainen O, Lautenschlager I. HHV-6 and HHV-7 antigenemia related to CMV infection after liver transplantation. J Med Virol. 2006;78:800-5 pubmed
    ..In this retrospective study, we investigated the occurrence of HHV-6 and HHV-7 antigenemia in relation to symptomatic CMV infection after liver transplantation...
  48. Lamoth F, Jayet P, Aubert J, Rotman S, Mottet C, Sahli R, et al. Case report: human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient. J Med Virol. 2008;80:1804-7 pubmed publisher
    ..A case of colitis associated with HHV-6B reactivation was observed in a lung transplant recipient. This case report suggests that symptomatic HHV-6 infection may occur in the absence of detectable viremia...
  49. Kamble R, Clark D, Leong H, Heslop H, Brenner M, Carrum G. Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;40:563-6 pubmed
    ..CI of HHV-6 may confound the interpretation of HHV-6 viremia after stem cell transplantation; consideration of the possibility of CI HHV-6 will avoid unnecessary antiviral therapy...
  50. Wang F, Yao K, Yin Q, Zhou F, Ding C, Peng G, et al. Human herpesvirus-6-specific interleukin 10-producing CD4+ T cells suppress the CD4+ T-cell response in infected individuals. Microbiol Immunol. 2006;50:787-803 pubmed
    ..These cells may play an important role in latent HHV-6 infection...
  51. Lehto J, Halme M, Tukiainen P, Harjula A, Sipponen J, Lautenschlager I. Human herpesvirus-6 and -7 after lung and heart-lung transplantation. J Heart Lung Transplant. 2007;26:41-7 pubmed
    ..We report the appearance of HHV-6 and HHV-7 antigenemia after lung transplantation and evaluate the efficacy of anti-viral drugs against these viruses...
  52. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int. 2006;55:1-8 pubmed
    ..This review includes discussion of the pathomechanism, the clinical symptoms, laboratory findings, pathological findings and therapy...
  53. Mori T, Tanaka Taya K, Satoh H, Aisa Y, Yamazaki R, Kato J, et al. Transmission of chromosomally integrated human herpesvirsus 6 (HHV-6) variant A from a parent to children leading to misdiagnosis of active HHV-6 infection. Transpl Infect Dis. 2009;11:503-6 pubmed publisher
    ..Since monitoring of HHV-6 by PCR has been widely introduced to the field of HSCT, transplant physicians should be aware of such an alternative form of HHV-6 transmission, particularly when HHV-6A is detected...
  54. Crawford J, Santi M, Thorarinsdottir H, Cornelison R, Rushing E, Zhang H, et al. Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas. J Clin Virol. 2009;46:37-42 pubmed publisher
    ..Human herpesvirus-6 (HHV-6) has been associated with a diverse spectrum of central nervous system (CNS) diseases and reported glial tropism...
  55. Caserta M, Hall C, Schnabel K, Lofthus G, Marino A, Shelley L, et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol. 2010;48:55-7 pubmed publisher
    ..Chromosomal integration of HHV-6 also occurs. Previous studies have suggested that the detection of HHV-6 DNA in plasma is an accurate marker of active viral replication...
  56. Clark D, Nacheva E, Leong H, Brazma D, Li Y, Tsao E, et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. J Infect Dis. 2006;193:912-6 pubmed
    ..We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease...
  57. Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, et al. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol. 2007;157:934-40 pubmed
    ..The association of human herpesvirus (HHV)-6 reactivation with DIHS has been reported by various groups...
  58. Ogata M, Kikuchi H, Satou T, Kawano R, Ikewaki J, Kohno K, et al. Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. J Infect Dis. 2006;193:68-79 pubmed
    ..Human herpesvirus 6 (HHV-6) is increasingly recognized as an opportunistic and potentially life-threatening pathogen in recipients of allogeneic stem cell transplants (SCTs)...
  59. Gautheret Dejean A, Henquell C, Mousnier F, Boutolleau D, Bonnafous P, Dhedin N, et al. Different expression of human herpesvirus-6 (HHV-6) load in whole blood may have a significant impact on the diagnosis of active infection. J Clin Virol. 2009;46:33-6 pubmed publisher
    ..Results are usually expressed as the number of genomic equivalent copies (gec) per mL of blood, although HHV-6 DNA in blood is mainly localized in lymphocytes and polymorphonuclear leukocytes...