herpesviridae infections

Summary

Summary: Virus diseases caused by the HERPESVIRIDAE.

Top Publications

  1. Zachariah A, Zong J, Long S, Latimer E, Heaggans S, RICHMAN L, et al. Fatal herpesvirus hemorrhagic disease in wild and orphan asian elephants in southern India. J Wildl Dis. 2013;49:381-93 pubmed publisher
    ..Instead, both the virus and the disease are evidently widespread in Asia and, despite the disease severity, Asian elephants appear to be the ancient endogenous hosts of both EEHV1A and EEHV1B...
  2. Rose N, Warren A, Whiteside D, Bidulka J, Robinson J, Illanes O, et al. Columbid herpesvirus-1 mortality in great horned owls (Bubo virginianus) from Calgary, Alberta. Can Vet J. 2012;53:265-8 pubmed
    ..The sequence of a PCR amplicon had 99.7% homology to Columbid herpesvirus-1...
  3. Andoh K, Takasugi M, Mahmoud H, Hattori S, Terada Y, Noguchi K, et al. Identification of a major immunogenic region of equine herpesvirus-1 glycoprotein E and its application to enzyme-linked immunosorbent assay. Vet Microbiol. 2013;164:18-26 pubmed publisher
    ..In conclusion, the ELISA described herein, using synthetic peptides, is a simple method to distinguish between EHV-1 and EHV-4 infections and will be suitable as a vaccine marker after introduction of EHV-1 ?gE into field horses...
  4. Gardiner D, Lunn D, Goehring L, Chiang Y, Cook C, Osterrieder N, et al. Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: viral loads in fetal and placental tissues and foals. Vaccine. 2012;30:6564-72 pubmed publisher
    ..Extremely high EHV-1 loads in decidua from abortions illustrate the infection risk posed to other horses...
  5. Wilkie G, Davison A, Watson M, Kerr K, Sanderson S, Bouts T, et al. Complete genome sequences of elephant endotheliotropic herpesviruses 1A and 1B determined directly from fatal cases. J Virol. 2013;87:6700-12 pubmed publisher
    ..The availability of the genome sequences will facilitate future research on the epidemiology, pathogenesis, diagnosis, and treatment of EEHV-associated disease...
  6. Perez K, Martínez F, Cosme Cruz R, Perez Crespo N, Tang Q. A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replication. J Virol. 2013;87:2639-47 pubmed publisher
    ..Our results suggest that the interactions of IE3 with IE3AM and with TBP stabilize the TFIID complex at the M112-113 promoter such that M112-113 gene expression can be activated and/or enhanced...
  7. Milho R, Frederico B, Efstathiou S, Stevenson P. A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry. PLoS Pathog. 2012;8:e1002986 pubmed publisher
    ..Thus the olfactory neuroepithelium provides an important and complex site of HS-dependent herpesvirus uptake...
  8. Epperson M, Lee C, Fremont D. Subversion of cytokine networks by virally encoded decoy receptors. Immunol Rev. 2012;250:199-215 pubmed publisher
    ..Structural and mechanistic studies of these decoy receptors have provided a wealth of information, not only about viral pathogenesis but also about the inner workings of cytokine signaling networks...
  9. Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse J, Rädle B, et al. Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. PLoS Pathog. 2012;8:e1002908 pubmed publisher
    ..In summary, this study pioneers real-time transcriptional analysis during a lytic herpesvirus infection and highlights numerous novel regulatory aspects of virus-host-cell interaction...

More Information

Publications89

  1. Frederico B, Milho R, May J, Gillet L, Stevenson P. Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4. PLoS Pathog. 2012;8:e1002935 pubmed publisher
    ..These data identify new complexity in rhadinovirus infection and potentially also new vulnerability to intervention...
  2. Zamora M. DNA viruses (CMV, EBV, and the herpesviruses). Semin Respir Crit Care Med. 2011;32:454-70 pubmed publisher
  3. Mitrovic M, Arapovic J, Jordan S, Fodil Cornu N, Ebert S, Vidal S, et al. The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response. J Virol. 2012;86:2165-75 pubmed publisher
  4. Sasaki M, Hasebe R, Makino Y, Suzuki T, Fukushi H, Okamoto M, et al. Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D. Genes Cells. 2011;16:343-57 pubmed publisher
    ..Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells...
  5. Coleman C, Nealy M, Tibbetts S. Immature and transitional B cells are latency reservoirs for a gammaherpesvirus. J Virol. 2010;84:13045-52 pubmed publisher
  6. Cardoso T, Ferrari H, Garcia A, Bregano L, Andrade A, Nogueira A. Immunohistochemical approach to the pathogenesis of clinical cases of bovine Herpesvirus type 5 infections. Diagn Pathol. 2010;5:57 pubmed publisher
    ..0001). These data open a new perspective in understanding the role of the AOP-1, MMP-9 and SNAP-25 proteins in mediating BoHV-5 pathogenesis and the strategies of host-virus interaction in order to invade the CNS. ..
  7. Diallo I, Hewitson G, Hoad J, Turner S, Corney B, Rodwell B. Isolation of bovine herpesvirus type 5 from the semen of a healthy bull in Australia. Aust Vet J. 2010;88:93-5 pubmed publisher
    ..The amplicon sequence shared 100% similarity with the published sequence of BoHV-5. This is the first report in Australia of BoHV-5 in semen. The implications of this finding are discussed...
  8. Butler L, Were W, Balinandi S, Downing R, Dollard S, Neilands T, et al. Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda. J Infect Dis. 2011;203:625-34 pubmed publisher
    ..10). Our data suggest that HHV-8 is acquired primarily through horizontal transmission in childhood from intrafamilial contacts and that transmission continues into adulthood potentially through nonsexual routes. ..
  9. Daley Bauer L, Wynn G, Mocarski E. Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes. Immunity. 2012;37:122-33 pubmed publisher
  10. Milho R, Gill M, May J, Colaco S, Stevenson P. In vivo function of the murid herpesvirus-4 ribonucleotide reductase small subunit. J Gen Virol. 2011;92:1550-60 pubmed publisher
    ..This seemed to reflect a requirement for lytic replication to occur in a terminally differentiated cell before a viable pool of latent genomes could be established...
  11. Azab W, Osterrieder N. Glycoproteins D of equine herpesvirus type 1 (EHV-1) and EHV-4 determine cellular tropism independently of integrins. J Virol. 2012;86:2031-44 pubmed publisher
    ..Cumulatively, we provide evidence that efficient EHV-1 and EHV-4 entry is dependent mainly on gD, which can bind to multiple cell surface receptors, and that gD has a defining role with respect to cellular host range of EHV-1 and EHV-4...
  12. Michel B, Fournier G, Lieffrig F, Costes B, Vanderplasschen A. Cyprinid herpesvirus 3. Emerg Infect Dis. 2010;16:1835-43 pubmed publisher
    ..nonreplicative). Recent advances with regard to CyHV-3 provide a role for this virus in fundamental and applied research...
  13. Sawada A, Koyama Sato M, Yasui M, Kondo O, Ishihara T, Takeshita Y, et al. Multiplex polymerase chain reaction for six herpesviruses after hematopoietic stem cell transplantation. Pediatr Int. 2011;53:1010-7 pubmed publisher
  14. Paludan S, Bowie A, Horan K, Fitzgerald K. Recognition of herpesviruses by the innate immune system. Nat Rev Immunol. 2011;11:143-54 pubmed publisher
  15. Lacaze P, Forster T, Ross A, Kerr L, Salvo Chirnside E, Lisnic V, et al. Temporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes. J Virol. 2011;85:6065-76 pubmed publisher
    ..Evidence is also presented to show, for the first time, genome-wide noncoding and bidirectional transcription at late stages of MCMV infection...
  16. Glauser D, Gillet L, Stevenson P. Virion endocytosis is a major target for murid herpesvirus-4 neutralization. J Gen Virol. 2012;93:1316-27 pubmed publisher
    ..Therefore, driving virion uptake appears to be an important function of gH-gL that provides a major target for antibody-mediated neutralization...
  17. Burrows S, Moss D, Khanna R. Understanding human T-cell-mediated immunoregulation through herpesviruses. Immunol Cell Biol. 2011;89:352-8 pubmed publisher
    ..It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases. ..
  18. El Matbouli M, Soliman H. Transmission of Cyprinid herpesvirus-3 (CyHV-3) from goldfish to naïve common carp by cohabitation. Res Vet Sci. 2011;90:536-9 pubmed publisher
    ..The results of this study demonstrate that goldfish is a carrier for CyHV-3, permit virus propagation, and disseminate the virus to susceptible carp causing the disease...
  19. Lisco A, Munawwar A, Introini A, Vanpouille C, Saba E, Feng X, et al. Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network. J Infect Dis. 2012;205:97-105 pubmed publisher
    ..However, semen is not just a mere passive transporter of virions but also plays an active role in HIV-1 transmission through cytokines and other biological factors...
  20. Gill M, May J, Colaco S, Stevenson P. Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract. J Virol. 2010;84:10937-42 pubmed publisher
    ..RNR could therefore provide a good target for gammaherpesvirus chemotherapy...
  21. Cicin Sain L, Brien J, Uhrlaub J, Drabig A, Marandu T, Nikolich Zugich J. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog. 2012;8:e1002849 pubmed publisher
    ..Therefore, latent MCMV infection resulted in pronounced changes of the T-cell compartment consistent with impaired naïve T-cell function...
  22. Miyoshi K, Nishida S, Sone E, Tajima Y, Makara M, Yoshioka M, et al. Molecular identification of novel alpha- and gammaherpesviruses from cetaceans stranded on Japanese coasts. Zoolog Sci. 2011;28:126-33 pubmed publisher
    ..Conversely, the novel gammaherpesviruses formed an independent clade distant from other known cetacean gammaherpesviruses. ..
  23. Arnizaut A, Hanson L. Antibody response of channel catfish after channel catfish virus infection and following dexamethasone treatment. Dis Aquat Organ. 2011;95:189-201 pubmed publisher
    ..The combined data suggest restricted re-activation of CCV in our experimental system. Primary and secondary responses and virus gene expression were demonstrated in CCVlacZ-exposed fish but were less frequent than in CCV-exposed fish...
  24. Gaspar M, May J, Sukla S, Frederico B, Gill M, Smith C, et al. Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog. 2011;7:e1002346 pubmed publisher
    ..In vitro MuHV-4 dramatically altered the DC cytoskeleton, suggesting that it manipulates DC migration and shape in order to spread. MuHV-4 therefore uses DCs to colonize B cells...
  25. Ogoina D, Onyemelukwe G, Musa B, Babadoko A. Seroprevalence and determinants of human herpes virus 8 infection in adult Nigerians with and without HIV-1 infection. Afr Health Sci. 2011;11:158-62 pubmed
    ..The higher prevalence of HHV8 infection in HIV-infected patients and its association with STD support a predominant sexual route of HHV8 transmission among adult Nigerians. ..
  26. Dewals B, Myster F, Palmeira L, Gillet L, Ackermann M, Vanderplasschen A. Ex vivo bioluminescence detection of alcelaphine herpesvirus 1 infection during malignant catarrhal fever. J Virol. 2011;85:6941-54 pubmed publisher
    ..Finally, we show that the infiltrating mononuclear leukocytes in nonlymphoid organs are mainly CD8(+) T cells and that latency is predominant during WD-MCF...
  27. Rakus K, Irnazarow I, Adamek M, Palmeira L, Kawana Y, Hirono I, et al. Gene expression analysis of common carp (Cyprinus carpio L.) lines during Cyprinid herpesvirus 3 infection yields insights into differential immune responses. Dev Comp Immunol. 2012;37:65-76 pubmed publisher
    ..It is also demonstrated that the outcome of this severe disease in large extent could be controlled by genetic factors of the host...
  28. Wilsterman S, Soboll Hussey G, Lunn D, Ashton L, Callan R, Hussey S, et al. Equine herpesvirus-1 infected peripheral blood mononuclear cell subpopulations during viremia. Vet Microbiol. 2011;149:40-7 pubmed publisher
    ..These results differ from what has been reported in in vitro studies, and indicate that different PBMC subpopulations may play different roles in EHV-1 viremia...
  29. Myoung J, Ganem D. Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells. Virology. 2011;413:1-11 pubmed publisher
    ..These results affirm the feasibility of studying KSHV infection in primary lymphoid cells, and help to rationalize the detection of KSHV DNA in rare human T cell lymphomas in vivo...
  30. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011;157:144-50 pubmed publisher
    ..This review summarizes our current understanding of how the CMVs suppress PCD and which signaling pathways they target...
  31. Wu T, Blackman M, Sun R. Prospects of a novel vaccination strategy for human gamma-herpesviruses. Immunol Res. 2010;48:122-46 pubmed publisher
    ..Progress in understanding persistent infections of EBV and KSHV raises the possibility of engineering a live attenuated virus without persistence. Therefore, we should keep the option open for developing a live EBV or KSHV vaccine...
  32. Freeman M, Burkum C, Jensen M, Woodland D, Blackman M. ?-Herpesvirus reactivation differentially stimulates epitope-specific CD8 T cell responses. J Immunol. 2012;188:3812-9 pubmed publisher
    ..Thus, our results demonstrate unexpected complexity in the response of CD8 T cells specific for different viral epitopes that were stimulated during acute infection, quiescent latency, and reactivation...
  33. Gunther T, Grundhoff A. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog. 2010;6:e1000935 pubmed publisher
    ..Our findings suggest that the modification patterns identified here induce a poised state of repression during viral latency, which can be rapidly reversed once the lytic cycle is induced...
  34. Eide K, Miller Morgan T, Heidel J, Kent M, Bildfell R, LaPatra S, et al. Investigation of koi herpesvirus latency in koi. J Virol. 2011;85:4954-62 pubmed publisher
    ..Our study suggests that KHV may become latent in leukocytes and other tissues, that it can be reactivated from latency by temperature stress, and that it may be more widespread in the koi population than previously suspected...
  35. Vomaske J, Denton M, Kreklywich C, Andoh T, Osborn J, Chen D, et al. Cytomegalovirus CC chemokine promotes immune cell migration. J Virol. 2012;86:11833-44 pubmed publisher
    ..Together our findings indicate that RCMV r129 is highly chemotactic, which has important implications during RCMV infection and reactivation and acceleration of TVS...
  36. Jones C, da Silva L, Sinani D. Regulation of the latency-reactivation cycle by products encoded by the bovine herpesvirus 1 (BHV-1) latency-related gene. J Neurovirol. 2011;17:535-45 pubmed publisher
    ..Although ORF2 is important for the latency-reactivation cycle, we predict that other LR gene products play a supportive role during life-long latency in cattle. ..
  37. Wimer C, Damiani A, Osterrieder N, Wagner B. Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression. Vet Immunol Immunopathol. 2011;140:266-74 pubmed publisher
    ..The data also implies that different EHV-1 strains have varying effects on all five chemokines, with the nuropathogenic strain, Ab4, having the greatest suppressive potential...
  38. Soboll Hussey G, Hussey S, Wagner B, Horohov D, Van De Walle G, Osterrieder N, et al. Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant. Vet Res. 2011;42:23 pubmed publisher
  39. Yoo J, Kang J, Lee H, Aguilar B, Kafka D, Lee S, et al. Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathog. 2010;6:e1001046 pubmed publisher
    ..Together, our study demonstrates that kaposin-B plays a key role in PROX1 upregulation during lymphatic reprogramming of blood vascular endothelial cells by KSHV...
  40. Russell G, Benavides J, Grant D, Todd H, Deane D, Percival A, et al. Duration of protective immunity and antibody responses in cattle immunised against alcelaphine herpesvirus-1-induced malignant catarrhal fever. Vet Res. 2012;43:51 pubmed publisher
    ..Interestingly, the high titre virus-neutralising antibody responses seen in animals that succumbed to MCF after vaccination were not protective...
  41. Raaperi K, Nurmoja I, Orro T, Viltrop A. Seroepidemiology of bovine herpesvirus 1 (BHV1) infection among Estonian dairy herds and risk factors for the spread within herds. Prev Vet Med. 2010;96:74-81 pubmed publisher
    ..The presence of bovine viral diarrhoea virus (BVDV) in a herd was associated with a higher prevalence of BHV1...
  42. Goehring L, Wagner B, Bigbie R, Hussey S, Rao S, Morley P, et al. Control of EHV-1 viremia and nasal shedding by commercial vaccines. Vaccine. 2010;28:5203-11 pubmed publisher
    ..This study demonstrated that both commercial vaccines significantly suppressed EHV-1 disease and nasal viral shedding, and one vaccine suppressed days of viremia...
  43. Speck S, Ganem D. Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host Microbe. 2010;8:100-15 pubmed publisher
    ..Here, we review the molecular basis of latency, with special attention to the gamma-herpesviruses, in which the understanding of this process is most advanced...
  44. Melchjorsen J. Sensing herpes: more than toll. Rev Med Virol. 2012;22:106-21 pubmed publisher
    ..In addition, I discuss the use of innate stimulation to improve anti-HSV treatment and vaccine response and I discuss future research aims...
  45. Michaud F, Coulombe F, Gaudreault E, Kriz J, Gosselin J. Involvement of TLR2 in recognition of acute gammaherpesvirus-68 infection. PLoS ONE. 2010;5:e13742 pubmed publisher
    ..Because murine gammaherpesvirus-68 (MHV-68) is a useful model to study human gammaherpesvirus pathogenesis in vivo, we evaluated the importance of mouse TLR2 in the recognition of MHV-68...
  46. Azab W, El Sheikh A, Abdel Gawad A. In vitro characterization of EHV-4 gG-deleted mutant. Virus Genes. 2012;44:109-11 pubmed publisher
    ..Furthermore, virus titers and plaque formation were comparable in both viruses. It is noteworthy that these findings disagree with the previously published study describing gG deletion in another EHV-4 strain...
  47. Marinaro M, Rezza G, Del Giudice G, Colao V, Tarsitano E, Camero M, et al. A caprine herpesvirus 1 vaccine adjuvanted with MF59™ protects against vaginal infection and interferes with the establishment of latency in goats. PLoS ONE. 2012;7:e34913 pubmed publisher
    ..Thus, a vaccine composed of inactivated CpHV-1 plus MF59™ as adjuvant was strongly immunogenic and induced effective immunity against vaginal CpHV-1 infection in goats...
  48. Stiglincová V, Chalupková A, Hrabovska Z, Cipková J, Wagnerova M, Mistrikova J. Vertical transmission of murine gammaherpesvirus 68 in mice. Acta Virol. 2011;55:55-9 pubmed
    ..Out of 10 infected pregnant mice just one died and another developed a tumor. All these results confirm the vertical transmission of MHV-68 in mice, teratogenicity of the virus and the virus shedding by breast milk...
  49. Oliveira M, Campos F, Dias M, Velho F, Freneau G, Brito W, et al. Detection of bovine herpesvirus 1 and 5 in semen from Brazilian bulls. Theriogenology. 2011;75:1139-45 pubmed publisher
    ..In conclusion, that both BoHV-1 and BoHV-5 were detected in bovine semen in Brazil highlighted the importance of examining bull semen in search for both agents to reduce the risk of transmitting these viruses...
  50. Orlova N, Fogg M, Carville A, Wang F. Antibodies to lytic infection proteins in lymphocryptovirus-infected rhesus macaques: a model for humoral immune responses to epstein-barr virus infection. Clin Vaccine Immunol. 2011;18:1427-34 pubmed publisher
    ..The rhesus macaque animal provides a unique perspective on humoral responses to EBV infection in humans and can be a valuable model for EBV vaccine development...
  51. Molloy M, Zhang W, Usherwood E. Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus. J Immunol. 2011;186:6218-26 pubmed publisher
    ..These data implicate IL-10 as a promising target for the restoration of immune surveillance against chronic ?-herpesvirus infection in immunosuppressed individuals...
  52. Maidana S, Ladelfa M, Pérez S, Lomónaco P, Del Médico Zajac M, Odeón A, et al. Characterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina. BMC Vet Res. 2011;7:8 pubmed publisher
    ..Outbreaks of BoHV-5 are regularly observed in Argentina suggesting the circulation of the virus in the bovine population...
  53. Soto S, Gonzalez B, Willoughby K, Maley M, Olvera A, Kennedy S, et al. Systemic herpesvirus and morbillivirus co-infection in a striped dolphin (Stenella coeruleoalba). J Comp Pathol. 2012;146:269-73 pubmed publisher
    ..To our knowledge, this is the first report of a cetacean co-infected by dolphin morbillivirus and herpesvirus with evidence of lesions attributable to both viruses...
  54. François S, Vidick S, Sarlet M, Michaux J, Koteja P, Desmecht D, et al. Comparative study of murid gammaherpesvirus 4 infection in mice and in a natural host, bank voles. J Gen Virol. 2010;91:2553-63 pubmed publisher
    ..Establishing transmission conditions in captivity will be a vital step for further research in this field...
  55. Silva Frade C, Gameiro R, Martins A, Cardoso T. Apoptotic and developmental effects of bovine Herpesvirus type-5 infection on in vitro-produced bovine embryos. Theriogenology. 2010;74:1296-303 pubmed publisher
    ..In conclusion, we inferred that BoHV-5 infected bovine oocytes, replicated, and suppressed some apoptotic pathways, without significantly affecting embryonic development...
  56. Cai Q, Verma S, Choi J, Ma M, Robertson E. Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. J Virol. 2010;84:11134-44 pubmed publisher
    ..Thus, these findings suggest that the IL-4/STAT6 signaling network is precisely controlled by KSHV for survival, maintenance of latency, and suppression of the host cytokine immune response of the virus-infected cells...
  57. Cardoso T, Antello T, Vieira F, Machado S, Nogueira A. Estimation of the diagnostic accuracy of the glyco-C and US9 gene-based polymerase chain reaction technique for the detection of bovine Herpesvirus type 5 DNA in decomposed brain suspension from a slaughter house using Bayesian analysis, Brazil. Trop Anim Health Prod. 2012;44:379-82 pubmed publisher
    ..However, given the importance of veterinary diagnoses, PCR-positive samples should be further confirmed through in vitro isolation and/or sequencing...
  58. Mutnal M, Cheeran M, Hu S, Lokensgard J. Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain. PLoS ONE. 2011;6:e16211 pubmed publisher
    ..This investigation focused on, analysis of cell types infected with mouse cytomegalovirus (MCMV) and the pattern of injury to the developing brain...
  59. Eide K, Miller Morgan T, Heidel J, Bildfell R, Jin L. Results of total DNA measurement in koi tissue by Koi Herpes Virus real-time PCR. J Virol Methods. 2011;172:81-4 pubmed publisher
    ..This study demonstrated that KHV genomic DNA can be detected in normal koi exposed previously to KHV and suggests that KHV becomes latent in fish...
  60. Slavuljica I, Busche A, Babic M, Mitrovic M, Gašparović I, Cekinović D, et al. Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. J Clin Invest. 2010;120:4532-45 pubmed publisher
    ..Together, our results indicate that use of a recombinant virus encoding the ligand for an activating NK cell receptor could be a powerful approach to developing a safe and immunogenic HCMV vaccine...
  61. Jarousse N, Trujillo D, Wilcox Adelman S, Coscoy L. Virally-induced upregulation of heparan sulfate on B cells via the action of type I IFN. J Immunol. 2011;187:5540-7 pubmed publisher
    ..Induction of HS expression at the B cell surface by stimulators of the innate immune response likely plays a key role in the development of a robust immune response...
  62. Clyde K, Glaunsinger B. Getting the message direct manipulation of host mRNA accumulation during gammaherpesvirus lytic infection. Adv Virus Res. 2010;78:1-42 pubmed publisher
  63. Tarakanova V, Stanitsa E, Leonardo S, Bigley T, Gauld S. Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. Virology. 2010;405:50-61 pubmed publisher
    ..Thus, our work reveals viral kinase-dependent regulation of gammaherpesvirus latency and illuminates a novel link between H2AX, a component of a tumor suppressor DDR network, and in vivo latency of a cancer-associated gammaherpesvirus...
  64. Bellière E, Esperón F, Arbelo M, Muñoz M, Fernandez A, Sanchez Vizcaino J. Presence of herpesvirus in striped dolphins stranded during the cetacean morbillivirus epizootic along the Mediterranean Spanish coast in 2007. Arch Virol. 2010;155:1307-11 pubmed publisher
    ..No HV lesions were found in any of the coinfected dolphins, which may indicate that HV did not contribute to the mortality in the CeMV outbreak. This is the first report of HV infection in any cetacean from the Mediterranean Sea...
  65. Nelson D, Davis W, Brown W, Li H, O Toole D, Oaks J. CD8(+)/perforin(+)/WC1(-) gammadelta T cells, not CD8(+) alphabeta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Vet Immunol Immunopathol. 2010;136:284-91 pubmed publisher
    ..Results of the present study support the previous suggestions that MCF is fundamentally a disease of immune dysregulation...
  66. Horst D, Ressing M, Wiertz E. Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls. Immunol Cell Biol. 2011;89:359-66 pubmed publisher
    ..Here, we review and discuss recent efforts to exploit human herpesvirus MHC class I evasion strategies for the rational design of novel strategies for vaccine development, cancer treatment, transplant protection and gene therapy...
  67. Suárez A, Kong R, George T, He L, Yue Z, van Dyk L. Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence. J Virol. 2011;85:6293-308 pubmed publisher
    ..This study reveals a viral mechanism which usurps the autophagic machinery to promote viral persistence within nonadherent ECs, with the potential for recovery of infected ECs at a distant site upon disruption of virus replication...
  68. Krogenæs A, Rootwelt V, Larsen S, Sjøberg E, Akselsen B, Skår T, et al. A serologic study of canine herpes virus-1 infection in the Norwegian adult dog population. Theriogenology. 2012;78:153-8 pubmed publisher
    ..In conclusion, this study strongly indicates that CHV1 infection is endemic in the dog population of Norway. There are significant differences in seroprevalence between geographic regions in the country...
  69. Barton E, Mandal P, Speck S. Pathogenesis and host control of gammaherpesviruses: lessons from the mouse. Annu Rev Immunol. 2011;29:351-97 pubmed publisher
    ..MHV68 represents a unique model to define the effects of chronic viral infection on the antiviral immune response...
  70. Tessmer M, Reilly E, Brossay L. Salivary gland NK cells are phenotypically and functionally unique. PLoS Pathog. 2011;7:e1001254 pubmed publisher
    ..Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells...
  71. Bannard O, Kraman M, Fearon D. Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection. J Immunol. 2010;185:7141-5 pubmed publisher
    ..Therefore, Ag-experienced, virus-specific CD8(+) T cell populations contain a subset that maintains replicative potential, despite long-term, persistent antigenic stimulation...
  72. Goehring L, Hussey G, Ashton L, Schenkel A, Lunn D. Infection of central nervous system endothelial cells by cell-associated EHV-1. Vet Microbiol. 2011;148:389-95 pubmed publisher
  73. Li H, Cunha C, Gailbreath K, O Toole D, White S, Vanderplasschen A, et al. Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits. Vet Microbiol. 2011;150:270-7 pubmed publisher
  74. Hughes D, Kipar A, Leeming G, Bennett E, Howarth D, Cummerson J, et al. Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host. PLoS Pathog. 2011;7:e1001321 pubmed publisher
  75. Dong X, Feng H, Sun Q, Li H, Wu T, Sun R, et al. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog. 2010;6:e1001001 pubmed publisher
    ..These findings support the conclusion that gammaHV68 hijacks the antiviral MAVS-IKKbeta pathway to promote viral transcription and lytic infection, representing an example whereby viral replication is coupled to host immune activation...
  76. Sunarto A, McColl K, Crane M, Sumiati T, Hyatt A, Barnes A, et al. Isolation and characterization of koi herpesvirus (KHV) from Indonesia: identification of a new genetic lineage. J Fish Dis. 2011;34:87-101 pubmed publisher
    ..The I(++)II(-) genotype has not been reported previously and appears to represent a new intermediate lineage that may have emerged in Indonesia...
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