lymphocytic choriomeningitis

Summary

Summary: A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Top Publications

  1. Munitic I, Decaluwe H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, et al. Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection. J Virol. 2009;83:11795-807 pubmed publisher
    ..we compared the functional properties of dominant and subdominant populations in the response to lymphocytic choriomeningitis virus (LCMV)...
  2. Blattman J, Grayson J, Wherry E, Kaech S, Smith K, Ahmed R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med. 2003;9:540-7 pubmed
    ..effects of IL-2 therapy during the expansion, contraction and memory phases of the T-cell response in lymphocytic choriomeningitis virus (LCMV)-infected mice...
  3. Botten J, Whitton J, Barrowman P, Sidney J, Whitmire J, Alexander J, et al. HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. J Virol. 2007;81:2307-17 pubmed
    The consequences of human lymphocytic choriomeningitis virus (LCMV) infection can be severe, including aseptic meningitis in immunocompetent individuals, hydrocephalus or chorioretinitis in fetal infection, or a highly lethal outcome in ..
  4. Waggoner S, Taniguchi R, Mathew P, Kumar V, Welsh R. Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis. J Clin Invest. 2010;120:1925-38 pubmed publisher
    ..We show here that persistent lymphocytic choriomeningitis virus (LCMV) infection of mice lacking 2B4 resulted in diminished LCMV-specific CD8+ T cell responses, ..
  5. Zhou S, Kurt Jones E, Mandell L, Cerny A, Chan M, Golenbock D, et al. MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur J Immunol. 2005;35:822-30 pubmed
    ..roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 (MyD88) in the course of a lymphocytic choriomeningitis virus (LCMV) infection and revealed the following: (i) studies of transfected cells and murine ..
  6. Crawford A, Angelosanto J, Nadwodny K, Blackburn S, Wherry E. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. PLoS Pathog. 2011;7:e1002098 pubmed publisher
    ..Our results demonstrate an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection. ..
  7. Blackburn S, Shin H, Haining W, Zou T, Workman C, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10:29-37 pubmed publisher
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  8. Althaus C, Ganusov V, de Boer R. Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2007;179:2944-51 pubmed
    Infection of mice with lymphocytic choriomeningitis virus (LCMV) is frequently used to study the underlying principles of viral infections and immune responses...
  9. Hinson E, Joshi N, Chen J, Rahner C, Jung Y, Wang X, et al. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010;184:5723-31 pubmed publisher
    ..In this study, we analyzed viperin expression in vivo during acute lymphocytic choriomeningitis virus Armstrong infection, which induces high levels of type I IFNs, and in persistently infected ..

More Information

Publications97

  1. Ejrnaes M, Filippi C, Martinic M, Ling E, Togher L, Crotty S, et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med. 2006;203:2461-72 pubmed
    ..this paper, we report that IL-10 production is drastically increased in mice persistently infected with lymphocytic choriomeningitis virus...
  2. Al Zein N, Boyce T, Correa A, Rodriguez V. Meningitis caused by lymphocytic choriomeningitis virus in a patient with leukemia. J Pediatr Hematol Oncol. 2008;30:781-4 pubmed publisher
    ..Meningitis caused by lymphocytic choriomeningitis virus was identified serologically...
  3. Jiang J, Zenewicz L, San Mateo L, Lau L, Shen H. Activation of antigen-specific CD8 T cells results in minimal killing of bystander bacteria. J Immunol. 2003;171:6032-8 pubmed
    ..This implication has a bearing on subunit vaccine design strategies and understanding failure of immunization against bacterial infection. ..
  4. Kotturi M, Swann J, Peters B, Arlehamn C, Sidney J, Kolla R, et al. Human CD8? and CD4? T cell memory to lymphocytic choriomeningitis virus infection. J Virol. 2011;85:11770-80 pubmed publisher
    Although cellular immunity to acute lymphocytic choriomeningitis virus (LCMV) infection has been well characterized in experimental studies in mice, the T cell response to this virus in humans is incompletely understood...
  5. Eschli B, Zellweger R, Wepf A, Lang K, Quirin K, Weber J, et al. Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus. J Virol. 2007;81:11650-7 pubmed
    b>Lymphocytic choriomeningitis virus (LCMV) is a murine arenavirus whose glycoprotein consists of a transmembrane subunit (GP-2) and a receptor-binding subunit (GP-1)...
  6. Rodriguez Carreno M, Nelson M, Botten J, Smith Nixon K, Buchmeier M, Whitton J. Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein. Virology. 2005;335:87-98 pubmed
    ..can induce CD8(+) T cell responses in mice and can protect against challenge with two arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV)...
  7. Montoya M, Edwards M, Reid D, Borrow P. Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN. J Immunol. 2005;174:1851-61 pubmed
    ..in spleen dendritic cell (sDC) subsets following infection of mice with a natural murine pathogen, lymphocytic choriomeningitis virus (LCMV)...
  8. Amman B, Pavlin B, Albarino C, Comer J, Erickson B, Oliver J, et al. Pet rodents and fatal lymphocytic choriomeningitis in transplant patients. Emerg Infect Dis. 2007;13:719-25 pubmed
    In April 2005, 4 transplant recipients became ill after receiving organs infected with lymphocytic choriomeningitis virus (LCMV); 3 subsequently died. All organs came from a donor who had been exposed to a hamster infected with LCMV...
  9. Suresh M, Singh A, Fischer C. Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection. J Virol. 2005;79:202-13 pubmed
    ..of tumor necrosis factor receptors (TNFRs) I (p55R) and II (p75R) in regulating CD8 T-cell responses to lymphocytic choriomeningitis virus (LCMV) with wild-type, p55R-deficient (p55(-/-)), p75R-deficient (p75(-/-)), and p55R- and p75R-..
  10. Fang C, Miwa T, Shen H, Song W. Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice. J Immunol. 2007;179:3178-86 pubmed
    ..We describe in this study a striking regulatory effect of DAF on the CD8+ T cell response to lymphocytic choriomeningitis virus (LCMV) infection...
  11. Richter K, Brocker T, Oxenius A. Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell. Eur J Immunol. 2012;42:2290-304 pubmed publisher
    ..Furthermore, exhaustion of virus-specific CD8(+) T cells leads to avoidance of life-threatening immunopathology...
  12. Pythoud C, Rodrigo W, Pasqual G, Rothenberger S, Martinez Sobrido L, de la Torre J, et al. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK?. J Virol. 2012;86:7728-38 pubmed publisher
    ..Consistent with previous studies, infection with the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) prevented phosphorylation of IRF3 in response to infection with Sendai virus, a strong ..
  13. Hunziker L, Ciurea A, Recher M, Hengartner H, Zinkernagel R. Public versus personal serotypes of a viral quasispecies. Proc Natl Acad Sci U S A. 2003;100:6015-20 pubmed
    ..In most inbred DBA2 mice infected with 2 x 10(4) or 2 x 10(6) plaque-forming units (pfu) of lymphocytic choriomeningitis virus (LCMV), the virus is transiently controlled below detectable levels measured with conventional ..
  14. Araki K, Gangappa S, Dillehay D, Rouse B, Larsen C, Ahmed R. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. J Exp Med. 2010;207:2355-67 pubmed publisher
    Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506...
  15. Pien G, Nguyen K, Malmgaard L, Satoskar A, Biron C. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol. 2002;169:5827-37 pubmed
    The kinetics of CD8 T cell IFN-gamma responses as they occur in situ are defined here during lymphocytic choriomeningitis virus (LCMV) infections, and a unique mechanism for the innate cytokines IFN-alphabeta and IL-18 in promoting these ..
  16. Jamieson D, Kourtis A, Bell M, Rasmussen S. Lymphocytic choriomeningitis virus: an emerging obstetric pathogen?. Am J Obstet Gynecol. 2006;194:1532-6 pubmed
    A report in May 2005 from the Centers for Disease Control and Prevention describing a cluster of lymphocytic choriomeningitis virus (LCMV) infections among 4 solid organ recipients has increased awareness of and clinical interest in this ..
  17. Fahey L, Wilson E, Elsaesser H, Fistonich C, McGavern D, Brooks D. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med. 2011;208:987-99 pubmed publisher
    ..Importantly, this sustained CD4 T cell functionality is critical to maintain immunity and ultimately aid in the control of persistent viral infection. ..
  18. Belnoue E, Fontannaz Bozzotti P, Grillet S, Lambert P, Siegrist C. Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. J Virol. 2007;81:7338-50 pubmed
    ..pattern of infection, we developed an infant infection murine model using the well-characterized lymphocytic choriomeningitis virus (LCMV) WE strain in 2-week-old BALB/c mice...
  19. Ng C, Oldstone M. Infected CD8?- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection. Proc Natl Acad Sci U S A. 2012;109:14116-21 pubmed publisher
    ..Our findings further illuminate the contribution of DCs to the production of IL-10 and to viral persistence...
  20. McGavern D, Homann D, Oldstone M. T cells in the central nervous system: the delicate balance between viral clearance and disease. J Infect Dis. 2002;186 Suppl 2:S145-51 pubmed
    ..The lymphocytic choriomeningitis virus model offers a unique system in which to evaluate the contrasting roles of specific T cells in ..
  21. Wherry E, Teichgräber V, Becker T, Masopust D, Kaech S, Antia R, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003;4:225-34 pubmed
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway. ..
  22. Maris C, Miller J, Altman J, Jacob J. A transgenic mouse model genetically tags all activated CD8 T cells. J Immunol. 2003;171:2393-401 pubmed
    ..We used the lymphocytic choriomeningitis virus infection model to track the dynamics of the antiviral CD8+ T cell responses...
  23. Kraft A, Wlodarczyk M, Kenney L, Selin L. PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol. 2013;87:12636-47 pubmed publisher
    Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 ..
  24. Mueller S, Ahmed R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2009;106:8623-8 pubmed publisher
    ..by different cell types on CD8(+) T cell responses during persistent infection of mice with lymphocytic choriomeningitis virus (LCMV) clone 13...
  25. Aichele P, Unsoeld H, Koschella M, Schweier O, Kalinke U, Vucikuja S. CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J Immunol. 2006;176:4525-9 pubmed
    ..T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR...
  26. van der Most R, Murali Krishna K, Lanier J, Wherry E, Puglielli M, Blattman J, et al. Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology. 2003;315:93-102 pubmed
    The H-2(b)-restricted CD8 T-cell response against lymphocytic choriomeningitis virus is directed against at least 10 dominant and subdominant epitopes, including two newly identified epitopes in the nucleoprotein...
  27. Richter K, Agnellini P, Oxenius A. On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection. Int Immunol. 2010;22:13-23 pubmed publisher
    ..Exhaustion of lymphocytic choriomeningitis virus (LCMV)-specific CD8 T cells was shown to be partially regulated by the inhibitory receptor ..
  28. Ledesma J, Fedele C, Carro F, Lledó L, Sanchez Seco M, Tenorio A, et al. Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain. Emerg Infect Dis. 2009;15:1677-80 pubmed publisher
    To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus)...
  29. Tagliapietra V, Rosa R, Hauffe H, Laakkonen J, Voutilainen L, Vapalahti O, et al. Spatial and temporal dynamics of lymphocytic choriomeningitis virus in wild rodents, northern Italy. Emerg Infect Dis. 2009;15:1019-25 pubmed publisher
    We determined the prevalence of infection with lymphocytic choriomeningitis virus (LCMV) among small mammals in northern Italy and analyzed long-term dynamics of LCMV in a rodent population in the province of Trento...
  30. Siddiqui S, Basta S. CD8+ T cell immunodominance in lymphocytic choriomeningitis virus infection is modified in the presence of toll-like receptor agonists. J Virol. 2011;85:13224-33 pubmed publisher
    ..that dual TLR2 plus TLR3 (designated TLR2+3) stimulation alters the immunodominance hierarchies of lymphocytic choriomeningitis virus (LCMV) epitopes by reducing NP396-specific CD8+ T cell responses and shifting it to a subdominant ..
  31. Kaech S, Tan J, Wherry E, Konieczny B, Surh C, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 2003;4:1191-8 pubmed
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  32. Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard W, et al. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog. 2013;9:e1003362 pubmed publisher
  33. Mothe B, Stewart B, Oseroff C, Bui H, Stogiera S, Garcia Z, et al. Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. J Immunol. 2007;179:1058-67 pubmed
    ..We investigated the question of how persistent infection impacted pre-existing lymphocytic choriomeningitis virus (LCMV)-specific CD4(+) T cell responses...
  34. Fischer S, Graham M, Kuehnert M, Kotton C, Srinivasan A, Marty F, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354:2235-49 pubmed
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  35. Singh A, Jatzek A, Plisch E, Srinivasan R, Svaren J, Suresh M. Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1. Mol Cell Biol. 2010;30:5145-59 pubmed publisher
    ..These findings provide critical insights into the cell cycle regulation of CD8 T-cell homeostasis and suggest that modulation of p27(Kip1) could bolster vaccine-induced T-cell memory and protective immunity...
  36. Kao C, Oestreich K, Paley M, Crawford A, Angelosanto J, Ali M, et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol. 2011;12:663-71 pubmed publisher
    ..Persistent antigenic stimulation caused downregulation of T-bet, which resulted in more severe exhaustion of CD8(+) T cells. Our observations suggest therapeutic opportunities involving higher T-bet expression during chronic infection...
  37. Punkosdy G, Blain M, Glass D, Lozano M, O Mara L, Dudley J, et al. Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens. Proc Natl Acad Sci U S A. 2011;108:3677-82 pubmed publisher
    ..Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3(+) Treg that is dependent on retroviral superantigen (sag) ..
  38. Bonthius D, Wright R, Tseng B, Barton L, Marco E, Karacay B, et al. Congenital lymphocytic choriomeningitis virus infection: spectrum of disease. Ann Neurol. 2007;62:347-55 pubmed
    b>Lymphocytic choriomeningitis virus (LCMV) is a human pathogen and an emerging neuroteratogen. When the infection occurs during pregnancy, the virus can target and damage the fetal brain and retina...
  39. Khanolkar A, Fuller M, Zajac A. T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus. Immunol Res. 2002;26:309-21 pubmed
    ..b>Lymphocytic choriomeningitis virus (LCMV) infection of mice has proven to be one of the most informative experimental systems for ..
  40. Macleod M, McKee A, Crawford F, White J, Kappler J, Marrack P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A. 2008;105:14521-6 pubmed publisher
    ..Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNgamma increased the proliferation of the memory cells...
  41. Labudova M, Tomaskova J, Skultety L, Pastorek J, Pastorekova S. The nucleoprotein of lymphocytic choriomeningitis virus facilitates spread of persistent infection through stabilization of the keratin network. J Virol. 2009;83:7842-9 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV) is a prototypic arenavirus containing a bisegmented single-stranded RNA genome with an ambisense coding strategy...
  42. Shedlock D, Talbott K, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, et al. A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine. 2011;29:6755-62 pubmed publisher
    ..We developed a highly optimized plasmid DNA vaccine that expresses the lymphocytic choriomeningitis virus (LCMV) nucleocapsid protein (NP) and evaluated it using the LCMV challenge model, a gold standard ..
  43. Foster E, Signs K, Marks D, Kapoor H, Casey M, Stobierski M, et al. Lymphocytic choriomeningitis in Michigan. Emerg Infect Dis. 2006;12:851-3 pubmed
    We summarize the first reported case of acquired lymphocytic choriomeningitis virus (LCMV) infection in Michigan to be investigated by public health authorities and provide evidence of the focal nature of LCMV infection in domestic ..
  44. McCausland M, Crotty S. Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J Virol Methods. 2008;147:167-76 pubmed
    ..We have developed a QPCR assay to accurately quantify lymphocytic choriomeningitis virus (LCMV) in infected mice. We first validated this assay using plasmid DNA and LCMV viral stocks...
  45. Wang Y, Swiecki M, Cella M, Alber G, Schreiber R, Gilfillan S, et al. Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe. 2012;11:631-42 pubmed publisher
    ..Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts ..
  46. de Boer R, Homann D, Perelson A. Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol. 2003;171:3928-35 pubmed
    We fit a mathematical model to data characterizing the primary cellular immune response to lymphocytic choriomeningitis virus...
  47. Lin Y, Roberts T, Sriram V, Cho S, Brutkiewicz R. Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection. Eur J Immunol. 2003;33:2736-43 pubmed
    ..Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b(+)CD8(+) and CD11c(+)CD8(+) T cells ..
  48. Graw F, Richter K, Oxenius A, Regoes R. Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection. Proc Biol Sci. 2011;278:3395-402 pubmed publisher
    ..the killing efficacy of CD8(+) T-cell responses in mice acutely and persistently infected with the lymphocytic choriomeningitis virus, using an in vivo CTL killing assay...
  49. Biron C, Nguyen K, Pien G. Innate immune responses to LCMV infections: natural killer cells and cytokines. Curr Top Microbiol Immunol. 2002;263:7-27 pubmed
  50. Mueller S, Langley W, Li G, Garcia Sastre A, Webby R, Ahmed R. Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections. J Immunol. 2010;185:2182-90 pubmed publisher
    ..and functional qualities of these cells with memory T cells generated after systemic infection with lymphocytic choriomeningitis virus (LCMV)...
  51. Hand T, Morre M, Kaech S. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A. 2007;104:11730-5 pubmed
    ..Altogether, these results reveal that IL-7Ralpha expression is permissive, but not instructive, to the creation of memory CD8 T cells...
  52. Hofer M, Carter S, Müller M, Campbell I. Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong. Viral Immunol. 2008;21:425-33 pubmed publisher
    Intracranial infection of mice with lymphocytic choriomeningitis virus (LCMV) results in a lethal neurological disease termed lymphocytic choriomeningitis (LCM) that is mediated by antiviral CD8(+) T cells...
  53. Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity. 2013;38:309-21 pubmed publisher
    ..Here we report that infection with acute Armstrong (ARM) or chronic Clone 13 (C13) strains of lymphocytic choriomeningitis virus (LCMV) led to two distinct phases of innate immune response...
  54. Takimoto K, Taharaguchi M, Morikawa S, Ike F, Yamada Y. Detection of the antibody to lymphocytic choriomeningitis virus in sera of laboratory rodents infected with viruses of laboratory and newly isolated strains by ELISA using purified recombinant nucleoprotein. Exp Anim. 2008;57:357-65 pubmed
    An enzyme-linked immunosorbent assay (ELISA) was developed to detect the antibody against lymphocytic choriomeningitis virus (LCMV) in sera of laboratory animals...
  55. Truong P, McGavern D. A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells. J Immunol. 2008;181:1161-9 pubmed
    ..In this study, we describe a virus carrier state that results from introducing lymphocytic choriomeningitis virus (LCMV) into adult mice possessing a restricted T cell repertoire...
  56. Pellegrini M, Calzascia T, Toe J, Preston S, Lin A, Elford A, et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011;144:601-13 pubmed publisher
    ..The IL-7-mediated effects were dependent on endogenous IL-6. These attributes of IL-7 have profound implications for its use as a therapeutic in the treatment of chronic viral diseases...
  57. Shin H, Blackburn S, Intlekofer A, Kao C, Angelosanto J, Reiner S, et al. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 2009;31:309-20 pubmed publisher
    ..Thus, we identify Blimp-1 as a transcriptional regulator of CD8(+) T cell exhaustion during chronic viral infection and propose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhaustion...
  58. Kim S, Welsh R. Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections. J Immunol. 2004;172:3139-50 pubmed
    ..Pichinde, vesicular stomatitis, vaccinia) viruses and subsequently challenged with acute or persistent lymphocytic choriomeningitis virus infections...
  59. Korns Johnson D, Homann D. Accelerated and improved quantification of lymphocytic choriomeningitis virus (LCMV) titers by flow cytometry. PLoS ONE. 2012;7:e37337 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV), a natural murine pathogen, is a member of the Arenavirus family, may cause atypical meningitis in humans, and has been utilized extensively as a model pathogen for the study of virus-induced ..
  60. Penaloza MacMaster P, Ur Rasheed A, Iyer S, Yagita H, Blazar B, Ahmed R. Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. J Virol. 2011;85:6168-74 pubmed publisher
    ..We investigated the effect of a transient CD70 blockade during an acute or a chronic lymphocytic choriomeningitis virus (LCMV) infection in mice...
  61. Sullivan B, Juedes A, Szabo S, von Herrath M, Glimcher L. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A. 2003;100:15818-23 pubmed
    ..Furthermore, mice lacking T-bet responded poorly to infection with lymphocytic choriomeningitis virus. T-bet is a key player in the generation of type 1 immunity, in both Th and T cytotoxic cells.
  62. Iannacone M, Sitia G, Isogawa M, Whitmire J, Marchese P, Chisari F, et al. Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. 2008;105:629-34 pubmed publisher
    We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin beta3...
  63. Fuller M, Hildeman D, Sabbaj S, Gaddis D, Tebo A, Shang L, et al. Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol. 2005;174:5926-30 pubmed
    ..Analyses of cytokine-producing activities by both mouse and human CD8 T cells further document that the extended maintenance of T cells in a CD127(low) state has functional consequences which manifest as an impairment of IL-2 production...
  64. Wilson E, Brooks D. Translating insights from persistent LCMV infection into anti-HIV immunity. Immunol Res. 2010;48:3-13 pubmed publisher
    ..b>Lymphocytic choriomeningitis virus (LCMV) is an established murine model of persistent viral infection that has been instrumental in ..
  65. Shin H, Blackburn S, Blattman J, Wherry E. Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. J Exp Med. 2007;204:941-9 pubmed
    ..These results indicate that antigen-specific CD8 T cell responses during persisting infection are maintained by a mechanism distinct from that after acute infection...
  66. Christensen J, Nansen A, Moos T, Lu B, Gerard C, Christensen J, et al. Efficient T-cell surveillance of the CNS requires expression of the CXC chemokine receptor 3. J Neurosci. 2004;24:4849-58 pubmed
    ..effector T-cells within the brain, CXCR3-deficient mice were infected intracerebrally with lymphocytic choriomeningitis virus (LCMV)...
  67. Tebo A, Fuller M, Gaddis D, Kojima K, Rehani K, Zajac A. Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses. J Virol. 2005;79:12703-13 pubmed
    ..By rechallenging mice that had cleared primary lymphocytic choriomeningitis virus infections, we revealed that the secondary response is remarkably swift...
  68. Bahl K, Hüebner A, Davis R, Welsh R. Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists. J Virol. 2010;84:4866-77 pubmed publisher
    ..It is dramatic at 2 to 4 days following lymphocytic choriomeningitis virus (LCMV) infection of mice and can be elicited by the IFN-inducing Toll receptor agonist poly(I:C)...
  69. Audigé A, Hofer U, Dittmer U, Van Den Broek M, Speck R. Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-? and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models. Viral Immunol. 2011;24:375-85 pubmed publisher
    ..Here we evaluated the effect of combining IFN-? and IL-7 on viral replication in vivo in the chronic lymphocytic choriomeningitis virus (LCMV) and acute Friend retrovirus (FV) infection models...
  70. Lee L, Burke S, Montoya M, Borrow P. Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice. J Immunol. 2009;182:7178-89 pubmed publisher
    ..1 IFN production during virus persistence, we analyzed type 1 IFN production during acute and chronic lymphocytic choriomeningitis virus (LCMV) infection...
  71. Dow C, Oseroff C, Peters B, Nance Sotelo C, Sidney J, Buchmeier M, et al. Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. J Virol. 2008;82:11734-41 pubmed publisher
    ..shown that responses against a broad set of nine CD4(+) T-cell epitopes were present in the setting of lymphocytic choriomeningitis virus (LCMV) Armstrong infection in the context of H-2(d)...
  72. Ortiz Riaño E, Cheng B, de la Torre J, Martinez Sobrido L. Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function. J Virol. 2012;86:3307-17 pubmed publisher
    ..Here we document self-association (homotypic interaction) of the NP of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), as well as those of the hemorrhagic fever (HF) arenaviruses Lassa virus (LASV) and ..
  73. Bonthius D, Mahoney J, Buchmeier M, Karacay B, Taggard D. Critical role for glial cells in the propagation and spread of lymphocytic choriomeningitis virus in the developing rat brain. J Virol. 2002;76:6618-35 pubmed
    Inoculation of the neonatal rat with lymphocytic choriomeningitis virus (LCMV) results in the selective infection of several neuronal populations and in focal pathological changes...
  74. Elsaesser H, Sauer K, Brooks D. IL-21 is required to control chronic viral infection. Science. 2009;324:1569-72 pubmed publisher
    ..Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection...
  75. Blattman J, Wherry E, Ha S, van der Most R, Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol. 2009;83:4386-94 pubmed publisher
    ..Here, we tracked the fate of virus-specific CD8 T cells in lymphocytic choriomeningitis virus (LCMV)-infected mice during viral clearance, the persistence of wild-type virus, or the selection ..
  76. Bergthaler A, Merkler D, Horvath E, Bestmann L, Pinschewer D. Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity. J Gen Virol. 2007;88:592-603 pubmed
    ..Here we exploited newly developed reverse-genetic techniques with Lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, to address specifically the contribution of the viral ..
  77. Osiak A, Utermöhlen O, Niendorf S, Horak I, Knobeloch K. ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005;25:6338-45 pubmed
    ..interferon-induced antiviral state and immune responses directed against vesicular stomatitis virus and lymphocytic choriomeningitis virus were not significantly altered in the absence of ISG15...
  78. Lledó L, Gegúndez M, Saz J, Bahamontes N, Beltrán M. Lymphocytic choriomeningitis virus infection in a province of Spain: analysis of sera from the general population and wild rodents. J Med Virol. 2003;70:273-5 pubmed
    b>Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne virus belonging to the family Arenaviridae, genus Arenavirus, which causes a wide spectrum of human disease. However, data on LCMV infection in Spain is scant...
  79. Badovinac V, Porter B, Harty J. Programmed contraction of CD8(+) T cells after infection. Nat Immunol. 2002;3:619-26 pubmed
    ..However, the onset and kinetics of CD8(+) T cell contraction after L. monocytogenes and lymphocytic choriomeningitis virus infections were independent of the magnitude of expansion, dose and duration of infection or ..
  80. Sommershof A, Basler M, Riether C, Engler H, Groettrup M. Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress. Brain Behav Immun. 2011;25:340-8 pubmed publisher
    ..the effects of chronic social stress on virus-specific CTL responses in mice after infection with lymphocytic choriomeningitis virus (LCMV)...
  81. Rutishauser R, Martins G, Kalachikov S, Chandele A, Parish I, Meffre E, et al. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity. 2009;31:296-308 pubmed publisher
    ..repressor Blimp-1 enhanced the formation of terminally differentiated CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection, and Blimp-1 deficiency promoted the acquisition of memory cell properties by ..
  82. Aneja R, Kalia V, Ahmed R, Joshi H. Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection. Mol Cancer Ther. 2007;6:2891-9 pubmed
    ..mg/kg) does not suppress cell-mediated immune responses in mice experimentally challenged with acute lymphocytic choriomeningitis virus infection, in that mice mount robust virus-specific CD8(+) and CD4(+) T-cell immune responses ..
  83. Tewari K, Nakayama Y, Suresh M. Role of direct effects of IFN-gamma on T cells in the regulation of CD8 T cell homeostasis. J Immunol. 2007;179:2115-25 pubmed
    ..These findings have clarified fundamental features of control of T cell homeostasis by IFN-gamma in the context of CD8 T cell memory and protective immunity...
  84. Kunz S, Rojek J, Roberts A, McGavern D, Oldstone M, de la Torre J. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. J Virol. 2006;80:9082-92 pubmed
    Neonatal infection of most mouse strains with lymphocytic choriomeningitis virus (LCMV) leads to a life-long persistent infection characterized by high virus loads in the central nervous system (CNS) in the absence of inflammation and ..
  85. Christensen J, de Lemos C, Moos T, Christensen J, Thomsen A. CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J Immunol. 2006;176:4235-43 pubmed
    ..This was done through analysis of CXCL10-deficient mice infected intracerebrally with lymphocytic choriomeningitis virus, which in normal immunocompetent mice induces a fatal CD8(+) T cell-mediated meningoencephalitis...
  86. Nussbaum A, Rodriguez Carreno M, Benning N, Botten J, Whitton J. Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. J Immunol. 2005;175:1153-60 pubmed
    ..In this study we investigated the CD8(+) T cell responses to lymphocytic choriomeningitis virus infection and DNA immunization in wild-type mice and in mice lacking the immunoproteasome ..
  87. Zhou S, Halle A, Kurt Jones E, Cerny A, Porpiglia E, Rogers M, et al. Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J Neuroimmunol. 2008;194:70-82 pubmed publisher
    ..In the present study, we demonstrated that central nervous system (CNS) glial cells are activated by Lymphocytic Choriomeningitis Virus (LCMV) in a TLR2-MyD88/Mal-dependent manner...
  88. Zahn R, Schelp I, Utermöhlen O, Von Laer D. A-to-G hypermutation in the genome of lymphocytic choriomeningitis virus. J Virol. 2007;81:457-64 pubmed
    ..Here, the potential role of ADAR1-L in the innate immune response to lymphocytic choriomeningitis virus (LCMV), a widely used virus model, was studied...