pseudorabies

Summary

Summary: A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals.

Top Publications

  1. Boadella M, Gortazar C, Vicente J, Ruiz Fons F. Wild boar: an increasing concern for Aujeszky's disease control in pigs?. BMC Vet Res. 2012;8:7 pubmed publisher
    ..Given the recent increase in wild boar abundance throughout Europe, we hypothesized that wild boar contact with ADV would remain stable in time even after significant reduction of ADV prevalence in domestic pigs...
  2. Han Y, Aleyas A, George J, Kim S, Kim H, Yoon H, et al. Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus. Exp Mol Med. 2008;40:583-95 pubmed
    Replication-incompetent adenoviruses expressing three major glycoproteins (gB, gC, and gD) of pseudorabies virus (PrV) were constructed and used to examine the ability of these glycoproteins to induce protective immunity against a lethal ..
  3. Albina E, Mesplède A, Chenut G, Le Potier M, Bourbao G, Le Gal S, et al. A serological survey on classical swine fever (CSF), Aujeszky's disease (AD) and porcine reproductive and respiratory syndrome (PRRS) virus infections in French wild boars from 1991 to 1998. Vet Microbiol. 2000;77:43-57 pubmed
    ..Thirty three of them were positive. The results on AD and PRRS antibody detection show that wild boars may constitute a reservoir for various infectious diseases of pigs. ..
  4. Allepuz A, Saez M, Solymosi N, Napp S, Casal J. The role of spatial factors in the success of an Aujeszky's disease eradication programme in a high pig density area (Northeast Spain, 2003-2007). Prev Vet Med. 2009;91:153-60 pubmed publisher
    ..Other herd-specific risk factors might be much more strongly related to the risk of a sow herd being ADV seropositive. ..
  5. Cao S, Chen H, Zhao J, Lu J, Xiao S, Jin M, et al. Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR. Vet Res Commun. 2005;29:263-9 pubmed
    Multiplex PCR was established to detect porcine circovirus type 2 (PCV-2), porcine parvovirus (PPV) and porcine pseudorabies virus (PRV) and applied to samples from 137 piglets exhibiting clinical signs of postweaning multisystemic ..
  6. Song C, Enquist L, Bartness T. New developments in tracing neural circuits with herpesviruses. Virus Res. 2005;111:235-49 pubmed
    ..each with its own unique infection characteristics, we focus on the widespread use of attenuated strains of pseudorabies virus (PRV), a swine herpesvirus with a broad host range...
  7. Pannwitz G, Freuling C, Denzin N, Schaarschmidt U, Nieper H, Hlinak A, et al. A long-term serological survey on Aujeszky's disease virus infections in wild boar in East Germany. Epidemiol Infect. 2012;140:348-58 pubmed publisher
    ..East Germany has been officially free of Aujeszky's disease (pseudorabies) in domestic pigs since 1985...
  8. Aleman N, Quiroga M, López Peña M, Vazquez S, Guerrero F, Nieto J. Induction and inhibition of apoptosis by pseudorabies virus in the trigeminal ganglion during acute infection of swine. J Virol. 2001;75:469-79 pubmed
    We examined the ability of pseudorabies virus (PRV) to induce and suppress apoptosis in the trigeminal ganglion during acute infection of its natural host...
  9. Bouma A, de Jong M, Kimman T. The influence of maternal immunity on the development of the in vitro lymphocyte proliferation response against pseudorabies virus in pigs. Res Vet Sci. 1998;64:167-71 pubmed
    In this study, the influence of maternal immunity against pseudorabies virus (PRV) on the development of a PRV-specific T-cell response in pigs was investigated...

More Information

Publications86

  1. Yang X, Forier K, Steukers L, Van Vlierberghe S, Dubruel P, Braeckmans K, et al. Immobilization of pseudorabies virus in porcine tracheal respiratory mucus revealed by single particle tracking. PLoS ONE. 2012;7:e51054 pubmed publisher
    b>Pseudorabies virus (PRV) initially replicates in the porcine upper respiratory tract. It easily invades the mucosae and submucosae for subsequent spread throughout the body via blood vessels and nervous system...
  2. Muller T, Klupp B, Freuling C, Hoffmann B, Mojcicz M, Capua I, et al. Characterization of pseudorabies virus of wild boar origin from Europe. Epidemiol Infect. 2010;138:1590-600 pubmed publisher
    b>Pseudorabies virus (PrV) infections appear to be more widely distributed in the European wild boar (Sus scrofa) population than assumed. In Europe, attempts to isolate and characterize the causative agents have been limited so far...
  3. Curanovic D, Enquist L. Virion-incorporated glycoprotein B mediates transneuronal spread of pseudorabies virus. J Virol. 2009;83:7796-804 pubmed publisher
    Transneuronal spread of pseudorabies virus (PRV) is a multistep process that requires several virally encoded proteins...
  4. Vicente J, Ruiz Fons F, Vidal D, Hofle U, Acevedo P, Villanúa D, et al. Serosurvey of Aujeszky's disease virus infection in European wild boar in Spain. Vet Rec. 2005;156:408-12 pubmed
    ..The seroprevalence in males more than one year old peaked after the breeding season, whereas females of the same age had a higher and constant seroprevalence throughout the year. ..
  5. Toth I, Boldogkoi Z, Medveczky I, Palkovits M. Lacrimal preganglionic neurons form a subdivision of the superior salivatory nucleus of rat: transneuronal labelling by pseudorabies virus. J Auton Nerv Syst. 1999;77:45-54 pubmed
    ..The Bartha strain of pseudorabies virus was injected into the lacrimal gland, and after different survival times, the superior cervical and ..
  6. Ch ng T, Spear P, Struyf F, Enquist L. Glycoprotein D-independent spread of pseudorabies virus infection in cultured peripheral nervous system neurons in a compartmented system. J Virol. 2007;81:10742-57 pubmed
    ..To study the role of the viral glycoprotein D (gD) in the directional spread of herpes simplex virus (HSV) and pseudorabies virus (PRV) infection, a culture system consisting of sympathetic neurons or epithelial cells in different ..
  7. Smeraski C, Sollars P, Ogilvie M, Enquist L, Pickard G. Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye. J Comp Neurol. 2004;471:298-313 pubmed
    Intraocular injection of the Bartha strain of pseudorabies virus (PRV Bartha) results in transsynaptic infection of the hypothalamic suprachiasmatic nucleus (SCN), a retinorecipient circadian oscillator...
  8. Ch ng T, Flood E, Enquist L. Culturing primary and transformed neuronal cells for studying pseudorabies virus infection. Methods Mol Biol. 2005;292:299-316 pubmed
    ..Methods are described for the use of a neurotropic herpesvirus, pseudorabies virus (PRV), to analyze the assembly, egress, and transport of viral antigens in neurons.
  9. Schuster F, Klupp B, Granzow H, Mettenleiter T. Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34. J Virol. 2012;86:2079-88 pubmed publisher
    ..b>Pseudorabies virus (PrV) pUL34 is a type II membrane protein of 262 amino acids (aa)...
  10. Riteau B, de Vaureix C, Lefèvre F. Trypsin increases pseudorabies virus production through activation of the ERK signalling pathway. J Gen Virol. 2006;87:1109-12 pubmed
    ..It is reported that exposure of pseudorabies virus-infected cells to trypsin increased virus production...
  11. Card J, Levitt P, Enquist L. Different patterns of neuronal infection after intracerebral injection of two strains of pseudorabies virus. J Virol. 1998;72:4434-41 pubmed
    b>Pseudorabies virus (PRV), a swine neurotropic alphaherpesvirus, is known to invade the central nervous system (CNS) of a variety of animal species through peripherally projecting axons, replicate in the parent neurons, and then pass ..
  12. Cano G, Card J, Sved A. Dual viral transneuronal tracing of central autonomic circuits involved in the innervation of the two kidneys in rat. J Comp Neurol. 2004;471:462-81 pubmed
    ..individual rats by dual viral transneuronal tracing using isogenic recombinant strains (PRV-152 and BaBlu) of pseudorabies virus...
  13. Kim S, Kim S, Han Y, Uyangaa E, Kim J, Choi J, et al. Co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing swine interleukin-18 and interferon-? provides enhanced Th1-biased protective immunity against inactivated vaccine of pseudorabies virus. Microbiol Immunol. 2012;56:529-40 pubmed publisher
    ..enterica serovar Typhimurium expressing swIL-18 and swIFN-? provide enhanced Th1-biased immunity against inactivated PrV vaccine to alleviate clinical signs caused by PrV challenge...
  14. Xiao S, Chen H, Fang L, Liu C, Zhang H, Jiang Y, et al. Comparison of immune responses and protective efficacy of suicidal DNA vaccine and conventional DNA vaccine encoding glycoprotein C of pseudorabies virus in mice. Vaccine. 2004;22:345-51 pubmed
    ..5) incorporating Semliki Forest virus (SFV) replicon and expressing glycoprotein C (gC) of pseudorabies virus (PrV) was investigated and compared with a conventional plasmid DNA vaccine (pcDC) encoding the same ..
  15. Paulus C, Sollars P, Pickard G, Enquist L. Transcriptome signature of virulent and attenuated pseudorabies virus-infected rodent brain. J Virol. 2006;80:1773-86 pubmed
    ..Thus, we systematically analyzed the host gene expression profile after acute pseudorabies virus (PRV) infection of the CNS using Affymetrix GeneChip technology...
  16. Ruiz Fons F, Rodriguez O, Mateu E, Vidal D, Gortazar C. Antibody response of wild boar (Sus scrofa) piglets vaccinated against Aujeszky's disease virus. Vet Rec. 2008;162:484-5 pubmed
  17. Klupp B, Fuchs W, Granzow H, Nixdorf R, Mettenleiter T. Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein. J Virol. 2002;76:3065-71 pubmed
    ..protein are present in all subfamilies of HERPESVIRIDAE: We sequenced the UL36 gene of the alphaherpesvirus pseudorabies virus (PrV) and prepared a monospecific polyclonal rabbit antiserum against a bacterial glutathione S-..
  18. Shiau A, Chen Y, Liao C, Huang Y, Wu C. Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis. Vaccine. 2001;19:3947-56 pubmed
    Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia coli induced protective immune responses...
  19. Ma M, Wang L, Yang J, Cai H, Shi J, Zhang S, et al. Age-related impaired Th1 responses to PRV vaccine in vivo in aged pigs. Mol Immunol. 2012;52:217-23 pubmed publisher
  20. Enquist L. Exploiting circuit-specific spread of pseudorabies virus in the central nervous system: insights to pathogenesis and circuit tracers. J Infect Dis. 2002;186 Suppl 2:S209-14 pubmed
    ..Live attenuated vaccine strains of pseudorabies virus (PRV), such as PRV Bartha, are among the most popular virus circuit tracers...
  21. Michael K, Klupp B, Karger A, Mettenleiter T. Efficient incorporation of tegument proteins pUL46, pUL49, and pUS3 into pseudorabies virus particles depends on the presence of pUL21. J Virol. 2007;81:1048-51 pubmed publisher
    The mature virion of the alphaherpesvirus pseudorabies virus (PrV) contains a minimum of 31 structural proteins which are recruited into the virus particle by a network of protein-protein interactions which is only incompletely understood...
  22. Ambagala A, Gopinath R, Srikumaran S. Inhibition of TAP by pseudorabies virus is independent of its vhs activity. Virus Res. 2003;96:37-48 pubmed
    Previously we have shown that pseudorabies virus (PrV) down-regulates the expression of porcine MHC class I molecules by interfering with the transporter associated with antigen processing (TAP)...
  23. Feierbach B, Piccinotti S, Bisher M, Denk W, Enquist L. Alpha-herpesvirus infection induces the formation of nuclear actin filaments. PLoS Pathog. 2006;2:e85 pubmed
    ..How these compartments are established and maintained remains poorly understood. Pseudorabies virus (PRV) is an alpha-herpesvirus often used to study herpesvirus invasion and spread in the nervous system...
  24. Blanchard Y, Le Meur N, Le Cunff M, Blanchard P, Léger J, Jestin A. Cellular gene expression survey of PseudoRabies Virus (PRV) infected Human Embryonic Kidney cells (HEK-293). Vet Res. 2006;37:705-23 pubmed
    b>Pseudorabies virus (PRV) is an alpha herpesvirus that causes Aujezsky disease in the pig...
  25. Mateusen B, Van Soom A, Maes D, Favoreel H, Nauwynck H. Receptor-determined susceptibility of preimplantation embryos to pseudorabies virus and porcine reproductive and respiratory syndrome virus. Biol Reprod. 2007;76:415-23 pubmed
    In the present study, the in vitro interaction of embryos with pseudorabies virus (PRV) and porcine reproductive and respiratory syndrome virus (PRRSV) was investigated by viral antigen detection and by evaluating the expression of virus ..
  26. Boadella M, Vicente J, Ruiz Fons F, de la Fuente J, Gortazar C. Effects of culling Eurasian wild boar on the prevalence of Mycobacterium bovis and Aujeszky's disease virus. Prev Vet Med. 2012;107:214-21 pubmed publisher
    ..We advocate that culling could become a part of integrated control strategies including habitat and game management changes and vaccination, contributing to increase their success likelihood, or reducing the total expenses...
  27. Böttcher S, Granzow H, Maresch C, Möhl B, Klupp B, Mettenleiter T. Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virus. J Virol. 2007;81:13403-11 pubmed
    ..Whereas an internal deletion of 709 amino acids (aa) within the C-terminal half of the alphaherpesvirus pseudorabies virus (PrV) pUL36 does not impair its function (S. Böttcher, B. G. Klupp, H. Granzow, W. Fuchs, K...
  28. Van De Walle G, Favoreel H, Nauwynck H, Pensaert M. Antibody-induced internalization of viral glycoproteins and gE-gI Fc receptor activity protect pseudorabies virus-infected monocytes from efficient complement-mediated lysis. J Gen Virol. 2003;84:939-48 pubmed
    b>Pseudorabies virus (PRV)-infected blood monocytes are able to transport virus throughout the body of vaccination-immune pigs...
  29. van Rooij E, Glansbeek H, Hilgers L, te Lintelo E, de Visser Y, Boersma W, et al. Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant. J Virol. 2002;76:10540-5 pubmed
    To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory motifs, and of the conventional adjuvants ..
  30. Hammond J, Jansen E, Morrissy C, Van Der Heide B, Goff W, Williamson M, et al. Vaccination of pigs with a recombinant porcine adenovirus expressing the gD gene from pseudorabies virus. Vaccine. 2001;19:3752-8 pubmed
    ..either a single dose or two doses of a recombinant porcine adenovirus expressing the glycoprotein D gene from pseudorabies virus (PRV)...
  31. Ren X, Sui X, Yin J. The effect of Houttuynia cordata injection on pseudorabies herpesvirus (PrV) infection in vitro. Pharm Biol. 2011;49:161-6 pubmed publisher
    b>Pseudorabies herpesvirus (PrV) belongs to the Alphaherpesvirinae. Piglets infected with PrV die within a few days. Development of effective antiviral agents is one alternative or complementary method to prevent PrV infection...
  32. Kramer T, Greco T, Enquist L, Cristea I. Proteomic characterization of pseudorabies virus extracellular virions. J Virol. 2011;85:6427-41 pubmed publisher
    b>Pseudorabies virus (PRV), a member of the Alphaherpesvirinae, has a complex multilayered extracellular virion that is structurally conserved among other herpesviruses...
  33. Flori L, Rogel Gaillard C, Cochet M, Lemonnier G, Hugot K, Chardon P, et al. Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epithelial cells during infection. BMC Genomics. 2008;9:123 pubmed publisher
    ..b>Pseudorabies virus (PrV), a porcine Alphaherpesvirus, is a good model for such studies in pig...
  34. En F, Wei X, Jian L, Qin C. Loop-mediated isothermal amplification establishment for detection of pseudorabies virus. J Virol Methods. 2008;151:35-9 pubmed publisher
    A rapid, convenient and reliable pseudorabies virus (PRV) detection system was developed by using the loop-mediated isothermal amplification (LAMP) method...
  35. Pomeranz L, Reynolds A, Hengartner C. Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine. Microbiol Mol Biol Rev. 2005;69:462-500 pubmed
    b>Pseudorabies virus (PRV) is a herpesvirus of swine, a member of the Alphaherpesvirinae subfamily, and the etiological agent of Aujeszky's disease...
  36. Brukman A, Enquist L. Suppression of the interferon-mediated innate immune response by pseudorabies virus. J Virol. 2006;80:6345-56 pubmed
    b>Pseudorabies virus (PRV) is an alphaherpesvirus related to the human pathogens herpes simplex virus type 1 (HSV-1) and varicella-zoster virus. PRV is capable of infecting and killing a wide variety of mammals...
  37. Zuckermann F. Aujeszky's disease virus: opportunities and challenges. Vet Res. 2000;31:121-31 pubmed
    ..This review presents a summary of research where ADV has been a valuable tool for the development of novel vaccines and has provided information to better understand the immune response of swine to infectious agents...
  38. Romero C, Meade P, Shultz J, Chung H, Gibbs E, Hahn E, et al. Venereal transmission of pseudorabies viruses indigenous to feral swine. J Wildl Dis. 2001;37:289-96 pubmed
    ..studies in which we attempted to determine the main routes of transmission involved in the natural infection of pseudorabies virus (PRV) indigenous to free-ranging feral swine (Sus scrofa)...
  39. De Bruin M, de Visser Y, Kimman T, Bianchi A. Time course of the porcine cellular and humoral immune responses in vivo against pseudorabies virus after inoculation and challenge: significance of in vitro antigenic restimulation. Vet Immunol Immunopathol. 1998;65:75-87 pubmed
    We investigated the time course of porcine cellular and humoral immune responses against pseudorabies virus (PRV) after pigs were inoculated with PRV gE(-) mutant strain M141 and challenged with wild-type virus NIA-3...
  40. Dory D, Fischer T, Béven V, Cariolet R, Rziha H, Jestin A. Prime-boost immunization using DNA vaccine and recombinant Orf virus protects pigs against Pseudorabies virus (Herpes suid 1). Vaccine. 2006;24:6256-63 pubmed
    ..study demonstrates the protective potential of a novel prime-boost vaccination strategy of pigs against lethal Pseudorabies virus (PRV; Herpes suid 1) infection...
  41. Desplanques A, Nauwynck H, Vercauteren D, Geens T, Favoreel H. Plasma membrane cholesterol is required for efficient pseudorabies virus entry. Virology. 2008;376:339-45 pubmed publisher
    ..comprise closely related viruses of man and animal, including herpes simplex virus, varicella-zoster virus and pseudorabies virus (PRV)...
  42. Van den Broeke C, Deruelle M, Nauwynck H, Coller K, Smith G, Van Doorsselaere J, et al. The kinase activity of pseudorabies virus US3 is required for modulation of the actin cytoskeleton. Virology. 2009;385:155-60 pubmed publisher
    ..The conserved US3 protein of the alphaherpesvirus pseudorabies virus induces actin stress fiber disassembly and formation of actin-containing cell projections, which are ..
  43. Fonseca A, Camargos M, de Oliveira A, Ciacci Zanella J, Patrício M, Braga A, et al. Molecular epidemiology of Brazilian pseudorabies viral isolates. Vet Microbiol. 2010;141:238-45 pubmed publisher
    b>Pseudorabies is a disease caused by pseudorabies virus (PRV) and is responsible for considerable economic losses in the swine industry...
  44. A Yoon H, Aleyas A, George J, Park S, Han Y, Hyun B, et al. Correlation between the nature of immunity induced by different immunogens and the establishment of latent infection by wild-type pseudorabies virus. Res Vet Sci. 2007;83:73-81 pubmed
    ..of immunity induced by different types of immunogens and the establishment of latent infection by wild-type pseudorabies virus (PrV), we used a murine model immunized with different immunogens, the PrV modified live vaccine (MLV), ..
  45. Card J, Kobiler O, Ludmir E, Desai V, Sved A, Enquist L. A dual infection pseudorabies virus conditional reporter approach to identify projections to collateralized neurons in complex neural circuits. PLoS ONE. 2011;6:e21141 pubmed publisher
    Replication and transneuronal transport of pseudorabies virus (PRV) are widely used to define the organization of neural circuits in rodent brain...
  46. Kim S, Kim S, Lee B, Han Y, Rahman M, Uyangaa E, et al. Oral administration of Salmonella enterica serovar Typhimurium expressing swine interleukin-18 induces Th1-biased protective immunity against inactivated vaccine of pseudorabies virus. Vet Microbiol. 2012;155:172-82 pubmed publisher
    ..interleukine-18 (swIL-18), known as IFN-?-inducing factor (IGIF), were evaluated in a vaccination model of pseudorabies virus (PrV) using attenuated Salmonella enterica serovar Typhimurium as the oral delivery system...
  47. van Rooij E, Rijsewijk F, Moonen Leusen H, Bianchi A, Rziha H. Comparison of different prime-boost regimes with DNA and recombinant Orf virus based vaccines expressing glycoprotein D of pseudorabies virus in pigs. Vaccine. 2010;28:1808-13 pubmed publisher
    ..Parapox virus) based vaccines have shown promise as alternatives for conventional vaccines in pigs against pseudorabies virus (PRV) infection causing Aujeszky's disease...
  48. van Nes A, de Jong M, Buijtels J, Verheijden J. Implications derived from a mathematical model for eradication of pseudorabies virus. Prev Vet Med. 1998;33:39-58 pubmed
    ..models based on experimental and observational data were applied to evaluate the feasibility of eradicating pseudorabies virus (PRV) regionally by vaccination and to determine which factors can jeopardise eradication...
  49. Tóth J, Tombácz D, Takács I, Boldogkoi Z. The effects of viral load on pseudorabies virus gene expression. BMC Microbiol. 2010;10:311 pubmed publisher
    ..In the present study, we have addressed the question of whether viral gene expressions are dependent on the multiplicity of infection by comparing gene expressions under low and high-MOI conditions...
  50. Grob P, Schijns V, van den Broek M, Cox S, Ackermann M, Suter M. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol. 1999;73:4748-54 pubmed
    ..To further our knowledge, pseudorabies virus, attenuated by deletion of the glycoprotein E gene to impair its neurovirulence and by deletion of the ..
  51. Bouma A, de Jong M, Kimman T. Comparison of two pseudorabies virus vaccines, that differ in capacity to reduce virus excretion after a challenge infection, in their capacity of reducing transmission of pseudorabies virus. Vet Microbiol. 1997;54:113-22 pubmed
    b>Pseudorabies virus (PRV) vaccines are often compared for their capacity to reduce virus excretion after a challenge infection. Vaccines, used for the eradication of PRV, however, should reduce transmission of PRV among pigs...
  52. Glorieux S, Favoreel H, Meesen G, de Vos W, Van den Broeck W, Nauwynck H. Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants. Vet Microbiol. 2009;136:341-6 pubmed publisher
    Different alphaherpesviruses, including pseudorabies virus (PRV), are able to cross the basement membrane barrier in nasal respiratory epithelium...
  53. Qian P, Li X, Jin M, Peng G, Chen H. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine. Vaccine. 2004;22:2129-36 pubmed
    Foot-and-mouth disease (FMD) and pseudorabies (PR) are two important infectious diseases in swine. An attenuated pseudorabies virus (PRV) has been successfully used as a gene delivery vector for the development of live-viral vaccines...
  54. Lyman M, Curanovic D, Brideau A, Enquist L. Fusion of enhanced green fluorescent protein to the pseudorabies virus axonal sorting protein Us9 blocks anterograde spread of infection in mammalian neurons. J Virol. 2008;82:10308-11 pubmed publisher
    b>Pseudorabies virus encodes a membrane protein (Us9) that is essential for the axonal sorting of virus particles within neurons and anterograde spread in the mammalian nervous system...
  55. Xu G, Xu X, Li Z, He Q, Wu B, Sun S, et al. Construction of recombinant pseudorabies virus expressing NS1 protein of Japanese encephalitis (SA14-14-2) virus and its safety and immunogenicity. Vaccine. 2004;22:1846-53 pubmed
    ..By plaque purification, PCR detection and southern hybridization, recombinant pseudorabies virus (PRV) expressing NS1 protein of JEV was acquired and named TK(-)/gG(-)/NS1(+)...
  56. Rassnick S, Enquist L, Sved A, Card J. Pseudorabies virus-induced leukocyte trafficking into the rat central nervous system. J Virol. 1998;72:9181-91 pubmed
    When the swine alphaherpesvirus pseudorabies virus (PRV) infects the rat retina, it replicates in retinal ganglion cells and invades the central nervous system (CNS) via anterograde transynaptic spread through axons in the optic nerve...
  57. Priola S, Stevens J. The 5' and 3' limits of transcription in the pseudorabies virus latency associated transcription unit. Virology. 1991;182:852-6 pubmed
    While latent in sensory neurons of infected pigs, pseudorabies virus expresses transcripts from a limited genomic area. These RNAs are transcribed from the strand opposite to that which encodes the pseudorabies immediate-early protein...
  58. Nauwynck H, Glorieux S, Favoreel H, Pensaert M. Cell biological and molecular characteristics of pseudorabies virus infections in cell cultures and in pigs with emphasis on the respiratory tract. Vet Res. 2007;38:229-41 pubmed
    ..several cell biological and molecular aspects of virus-cell and virus-host (pig) interactions are reviewed for pseudorabies (Aujeszky's disease) virus...
  59. Wu Y, Chen D, He H, Chen D, Chen L, Chen H, et al. Pseudorabies virus infected porcine epithelial cell line generates a diverse set of host microRNAs and a special cluster of viral microRNAs. PLoS ONE. 2012;7:e30988 pubmed publisher
    b>Pseudorabies virus (PRV) belongs to Alphaherpesvirinae subfamily that causes huge economic loss in pig industry worldwide...
  60. Hara Y, Hasebe R, Sunden Y, Ochiai K, Honda E, Sakoda Y, et al. Propagation of swine hemagglutinating encephalomyelitis virus and pseudorabies virus in dorsal root ganglia cells. J Vet Med Sci. 2009;71:595-601 pubmed
    ..In the present study, we investigated the infectivity and propagation of HEV in comparison with those of pseudorabies virus (PRV), another neurotropic virus, using dorsal root ganglia cells of newborn mice containing nerve cells ..
  61. Tudor D, Riffault S, Carrat C, Lefevre F, Bernoin M, Charley B. Type I IFN modulates the immune response induced by DNA vaccination to pseudorabies virus glycoprotein C. Virology. 2001;286:197-205 pubmed
    ..chain of the type I IFN receptor (IFNAR K/O mice) were immunized with a plasmid encoding glycoprotein C of pseudorabies virus (PRV-gC)...
  62. Gut Winiarska M, Jacobs L, Kerstens H, Bienkowska Szewczyk K. A highly specific and sensitive sandwich blocking ELISA based on baculovirus expressed pseudorabies virus glycoprotein B. J Virol Methods. 2000;88:63-71 pubmed
    ..ELISA) based on the reaction between a monoclonal antibody (MAb) and a recombinant glycoprotein B (gB) of pseudorabies virus (PRV) was developed...
  63. Berke O, Grosse Beilage E. Spatial relative risk mapping of pseudorabies-seropositive pig herds in an animal-dense region. J Vet Med B Infect Dis Vet Public Health. 2003;50:322-5 pubmed
    ..The spatial epidemiological analysis is based on geographically referenced data about pseudorabies (Aujeszky's disease) virus infections at farm level in a region of high animal density in Germany at the ..
  64. Pasdeloup D, Labetoulle M, Rixon F. Differing effects of herpes simplex virus 1 and pseudorabies virus infections on centrosomal function. J Virol. 2013;87:7102-12 pubmed publisher
    ..MTOC in HSV-1-infected cells, but it retains this function in cells infected by another alphaherpesvirus, pseudorabies virus (PrV)...
  65. Hong Q, Qian P, Li X, Yu X, Chen H. A recombinant pseudorabies virus co-expressing capsid proteins precursor P1-2A of FMDV and VP2 protein of porcine parvovirus: a trivalent vaccine candidate. Biotechnol Lett. 2007;29:1677-83 pubmed
    b>Pseudorabies (PR), foot-and-mouth disease (FMD), and porcine parvovirus disease are three important infectious diseases in swine worldwide...
  66. Klupp B, Lomniczi B, Visser N, Fuchs W, Mettenleiter T. Mutations affecting the UL21 gene contribute to avirulence of pseudorabies virus vaccine strain Bartha. Virology. 1995;212:466-73 pubmed
    Analysis of the live attenuated pseudorabies virus (PrV) vaccine strain Bartha indicated location of a major determinant for PrV neurovirulence within the genomic BamHI fragment 4 (B. Lomniczi et al., 1984, J. Virol. 52, 198-205)...
  67. Ju C, Fan H, Tan Y, Liu Z, Xi X, Cao S, et al. Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2. Vet Microbiol. 2005;109:179-90 pubmed
    Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS). Pseudorabies (PR) is also an important infectious disease in swine and sometimes co-infect with PCV2...
  68. Muller T, Hahn E, Tottewitz F, Kramer M, Klupp B, Mettenleiter T, et al. Pseudorabies virus in wild swine: a global perspective. Arch Virol. 2011;156:1691-705 pubmed publisher
    Suid herpesvirus 1 (SuHV1, syn. Aujeszky's disease virus [ADV] or pseudorabies virus [PrV]), which belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus is the causative agent of Aujeszky's disease (AD, ..
  69. Ming F, Yang J, Chu P, Ma M, Shi J, Cai H, et al. Immunization of aged pigs with attenuated pseudorabies virus vaccine combined with CpG oligodeoxynucleotide restores defective Th1 immune responses. PLoS ONE. 2013;8:e65536 pubmed publisher
    ..Here we investigated whether immunization of aged pig model with attenuated pseudorabies virus vaccine (PRV vaccine) formulated with CpG ODN could promote a successful development of immune responses ..
  70. Skiba M, Mettenleiter T, Karger A. Quantitative whole-cell proteome analysis of pseudorabies virus-infected cells. J Virol. 2008;82:9689-99 pubmed publisher
    ..acids in cell culture technique was performed on bovine kidney cells after infection with the alphaherpesvirus pseudorabies virus (PrV), the etiological agent of Aujeszky's disease...
  71. Yuan Z, Zhang S, Liu Y, Zhang F, Fooks A, Li Q, et al. A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs. Vaccine. 2008;26:1314-21 pubmed publisher
    ..b>Pseudorabies virus (PRV) has been licensed for use as a live vaccine in pigs and possesses an excellent safety and efficacy ..
  72. Ch ng T, Enquist L. Neuron-to-cell spread of pseudorabies virus in a compartmented neuronal culture system. J Virol. 2005;79:10875-89 pubmed
    ..Using pseudorabies virus as a model, we infected neuron cell bodies grown in Teflon chambers and observed spread of infection to ..
  73. Reiner G, Melchinger E, Kramarova M, Pfaff E, Büttner M, Saalmuller A, et al. Detection of quantitative trait loci for resistance/susceptibility to pseudorabies virus in swine. J Gen Virol. 2002;83:167-72 pubmed
    This study describes genetic differences in resistance/susceptibility to pseudorabies virus (PrV) between European Large White and Chinese Meishan pigs, with a mapping of quantitative trait loci (QTL) obtained from a genome-wide scan in F(..
  74. Linghua Z, Xingshan T, Fengzhen Z. In vivo oral administration effects of various oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets. Vaccine. 2008;26:224-33 pubmed
    ..We have previously demonstrated that human-specific CpG ODN is a potent adjuvant to pseudorabies live attenuated virus (PRV) vaccine when administered subcutaneously (SC) or ocularly in piglets...
  75. Narita M, Ishii M. Encephalomalacic lesions in pigs dually infected with porcine reproductive and respiratory syndrome virus and pseudorabies virus. J Comp Pathol. 2004;131:277-84 pubmed
    ..with an aerosol containing porcine reproductive and respiratory syndrome virus (PRRSV) followed 7 days later by pseudorabies virus (PRV)...
  76. Van De Walle G, Favoreel H, Nauwynck H, Van Oostveldt P, Pensaert M. Antibody-induced internalization of viral glycoproteins in pseudorabies virus-infected monocytes and role of the cytoskeleton: a confocal study. Vet Microbiol. 2002;86:51-7 pubmed
    Addition of pseudorabies virus (PrV)-specific polyclonal immunoglobulins to PrV-infected monocytes induces internalization of plasma membrane anchored viral glycoproteins...
  77. Sedegah M, Beaudoin R, Majarian W, Cochran M, Chiang C, Sadoff J, et al. Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and Salmonella transformed with circumsporozoite gene. Bull World Health Organ. 1990;68 Suppl:109-14 pubmed
    ..yoelii circumsporozoite (CS) protein was engineered into three live vectors: vaccinia, attenuated pseudorabies, and attenuated Salmonella typhimurium...