rift valley fever

Summary

Summary: An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.

Top Publications

  1. Fernandez J, Billecocq A, Durand J, Cêtre Sossah C, Cardinale E, Marianneau P, et al. The nonstructural protein NSs induces a variable antibody response in domestic ruminants naturally infected with Rift Valley fever virus. Clin Vaccine Immunol. 2012;19:5-10 pubmed publisher
    b>Rift Valley fever (RVF) is an emerging zoonosis in Africa which has spread to Egypt, the Arabian Peninsula, Madagascar, and Comoros...
  2. Indran S, Ikegami T. Novel approaches to develop Rift Valley fever vaccines. Front Cell Infect Microbiol. 2012;2:131 pubmed publisher
    b>Rift Valley fever (RVF) is endemic to sub-Saharan Africa, and has spread into Madagascar, Egypt, Saudi Arabia, and Yemen...
  3. Garcia S, Crance J, Billecocq A, Peinnequin A, Jouan A, Bouloy M, et al. Quantitative real-time PCR detection of Rift Valley fever virus and its application to evaluation of antiviral compounds. J Clin Microbiol. 2001;39:4456-61 pubmed
    The Rift Valley fever virus (RVFV), a member of the genus Phlebovirus (family Bunyaviridae) is an enveloped negative-strand RNA virus with a tripartite genome...
  4. Morrill J, Laughlin R, Lokugamage N, Pugh R, Sbrana E, Weise W, et al. Safety and immunogenicity of recombinant Rift Valley fever MP-12 vaccine candidates in sheep. Vaccine. 2013;31:559-65 pubmed publisher
    The safety and immunogenicity of two authentic recombinant (ar) Rift Valley fever (RVF) viruses, one with a deletion in the NSs region of the S RNA segment (arMP-12ΔNSs16/198) and the other with a large deletion of the NSm gene in the ..
  5. Euler M, Wang Y, Nentwich O, Piepenburg O, Hufert F, Weidmann M. Recombinase polymerase amplification assay for rapid detection of Rift Valley fever virus. J Clin Virol. 2012;54:308-12 pubmed publisher
    Detection of nucleic acids of Rift Valley fever virus (RVFV) has been shown to be useful in field diagnostics. To develop an isothermal 'recombinase polymerase amplification (RPA)' assay on an ESEquant tubescanner device...
  6. Xu F, Liu D, Nunes M, Da Rosa A, Tesh R, Xiao S. Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus Phlebovirus (Bunyaviridae). Am J Trop Med Hyg. 2007;76:1194-200 pubmed
    ..that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans...
  7. Kortekaas J, de Boer S, Kant J, Vloet R, Antonis A, Moormann R. Rift Valley fever virus immunity provided by a paramyxovirus vaccine vector. Vaccine. 2010;28:4394-401 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes recurrent large outbreaks among humans and livestock...
  8. Ikegami T, Makino S. Rift valley fever vaccines. Vaccine. 2009;27 Suppl 4:D69-72 pubmed publisher
    b>Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, is a negative-stranded RNA virus carrying a tripartite RNA genome...
  9. Shafagati N, Narayanan A, Baer A, FITE K, Pinkham C, Bailey C, et al. The use of NanoTrap particles as a sample enrichment method to enhance the detection of Rift Valley Fever Virus. PLoS Negl Trop Dis. 2013;7:e2296 pubmed publisher
    b>Rift Valley Fever Virus (RVFV) is a zoonotic virus that is not only an emerging pathogen but is also considered a biodefense pathogen due to the threat it may cause to public health and national security...

More Information

Publications113 found, 100 shown here

  1. Morrill J, Laughlin R, Lokugamage N, Wu J, Pugh R, Kanani P, et al. Immunogenicity of a recombinant Rift Valley fever MP-12-NSm deletion vaccine candidate in calves. Vaccine. 2013;31:4988-94 pubmed publisher
    The safety and immunogenicity of an authentic recombinant (ar) of the live, attenuated MP-12 Rift Valley fever (RVF) vaccine virus with a large deletion of the NSm gene in the pre-Gn region of the M RNA segment (arMP-12?NSm21/384) was ..
  2. Peyrefitte C, Boubis L, Coudrier D, Bouloy M, Grandadam M, Tolou H, et al. Real-time reverse-transcription loop-mediated isothermal amplification for rapid detection of rift valley Fever virus. J Clin Microbiol. 2008;46:3653-9 pubmed publisher
    ..loop-mediated isothermal amplification (RT-LAMP) for the detection of the L RNA segment of Rift Valley fever virus (RVFV) are described...
  3. Munyua P, Murithi R, Wainwright S, Githinji J, Hightower A, Mutonga D, et al. Rift Valley fever outbreak in livestock in Kenya, 2006-2007. Am J Trop Med Hyg. 2010;83:58-64 pubmed publisher
    We analyzed the extent of livestock involvement in the latest Rift Valley fever (RVF) outbreak in Kenya that started in December 2006 and continued until June 2007...
  4. Métras R, Baguelin M, Edmunds W, Thompson P, Kemp A, Pfeiffer D, et al. Transmission potential of Rift Valley fever virus over the course of the 2010 epidemic in South Africa. Emerg Infect Dis. 2013;19:916-24 pubmed publisher
    A Rift Valley fever (RVF) epidemic affecting animals on domestic livestock farms was reported in South Africa during January-August 2010. The first cases occurred after heavy rainfall, and the virus subsequently spread countrywide...
  5. Miller B, Godsey M, Crabtree M, Savage H, Al Mazrao Y, Al Jeffri M, et al. Isolation and genetic characterization of Rift Valley fever virus from Aedes vexans arabiensis, Kingdom of Saudi Arabia. Emerg Infect Dis. 2002;8:1492-4 pubmed
    An outbreak of Rift Valley fever in the Kingdom of Saudi Arabia and Yemen in 2000 was the first recognized occurrence of the illness outside of Africa and Madagascar...
  6. Turell M, Lee J, Richardson J, Sang R, Kioko E, Agawo M, et al. Vector competence of Kenyan Culex zombaensis and Culex quinquefasciatus mosquitoes for Rift Valley fever virus. J Am Mosq Control Assoc. 2007;23:378-82 pubmed
    b>Rift Valley fever (RVF) continues to be a significant problem in Kenya as well as in Egypt, Yemen, and Saudi Arabia...
  7. Näslund J, Lagerqvist N, Lundkvist A, Evander M, Ahlm C, Bucht G. Kinetics of Rift Valley Fever Virus in experimentally infected mice using quantitative real-time RT-PCR. J Virol Methods. 2008;151:277-82 pubmed publisher
    b>Rift Valley Fever (RVF) is an important viral zoonosis in Africa affecting animals and humans...
  8. Chevalier V, Thiongane Y, Lancelot R. Endemic transmission of Rift Valley Fever in Senegal. Transbound Emerg Dis. 2009;56:372-4 pubmed publisher
    b>Rift Valley fever (RVF) is an expanding zoonotic disease transmitted from ruminant to ruminant by Culicidae mosquitoes...
  9. Morrill J, Peters C. Pathogenicity and neurovirulence of a mutagen-attenuated Rift Valley fever vaccine in rhesus monkeys. Vaccine. 2003;21:2994-3002 pubmed
    Rhesus macaques, intravenously inoculated with virulent Rift Valley fever virus, develop viremia and biochemical evidence of liver damage and serve as a model for human disease...
  10. Moutailler S, Krida G, Schaffner F, Vazeille M, Failloux A. Potential vectors of Rift Valley fever virus in the Mediterranean region. Vector Borne Zoonotic Dis. 2008;8:749-53 pubmed publisher
    ..Aedes vexans, Anopheles gambiae, Culex pipiens, Culex quinquefasciatus) to disseminate two strains of Rift Valley fever virus (RVFV), the virulent ZH548 and the avirulent Clone 13...
  11. Gommet C, Billecocq A, Jouvion G, Hasan M, Zaverucha do Valle T, Guillemot L, et al. Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice. PLoS Negl Trop Dis. 2011;5:e1421 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes disease in livestock and humans. It can be transmitted by mosquitoes, inhalation or physical contact with the body fluids of infected animals...
  12. Kahlon S, Peters C, LeDuc J, Muchiri E, Muiruri S, Njenga M, et al. Severe Rift Valley fever may present with a characteristic clinical syndrome. Am J Trop Med Hyg. 2010;82:371-5 pubmed publisher
    b>Rift Valley fever (RVF) virus is an emerging pathogen that is transmitted in many regions of sub-Saharan Africa, parts of Egypt, and the Arabian peninsula...
  13. Ba Y, Sall A, Diallo D, Mondo M, Girault L, Dia I, et al. Re-emergence of Rift Valley fever virus in Barkedji (Senegal, West Africa) in 2002-2003: identification of new vectors and epidemiological implications. J Am Mosq Control Assoc. 2012;28:170-8 pubmed
    The Rift Valley fever virus (RVFV) is a threat that must not be neglected, as the consequences of RVFV are dramatic, both for human and animal health...
  14. Shoemaker T, Boulianne C, Vincent M, Pezzanite L, Al Qahtani M, Al Mazrou Y, et al. Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01. Emerg Infect Dis. 2002;8:1415-20 pubmed
    The first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths...
  15. Bird B, Albarino C, Nichol S. Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease. Virology. 2007;362:10-5 pubmed
    b>Rift Valley fever virus is a significant human and veterinary pathogen responsible for explosive outbreaks throughout Africa and the Arabian Peninsula...
  16. Morrill J, Peters C. Mucosal immunization of rhesus macaques with Rift Valley Fever MP-12 vaccine. J Infect Dis. 2011;204:617-25 pubmed publisher
    Rhesus macaques given 5 × 10(4) or 1 × 10(5) plaque-forming units (pfu) of Rift Valley fever (RVF) MP-12 vaccine by oral, intranasal drops, or small particle aerosol showed no adverse effects up to 56 days after administration...
  17. Cêtre Sossah C, Zeller H, Grandadam M, Caro V, Pettinelli F, Bouloy M, et al. Genome analysis of Rift Valley fever virus, Mayotte. Emerg Infect Dis. 2012;18:969-71 pubmed publisher
    As further confirmation of a first human case of Rift Valley fever in 2007 in Comoros, we isolated Rift Valley fever virus in suspected human cases. These viruses are genetically closely linked to the 2006-2007 isolates from Kenya.
  18. Abdel Wahab K, El Baz L, El Tayeb E, Omar H, Ossman M, Yasin W. Rift Valley Fever virus infections in Egypt: Pathological and virological findings in man. Trans R Soc Trop Med Hyg. 1978;72:392-6 pubmed
    Ten strains of Rift Valley Fever virus were isolated from serum samples from acute human cases collected during an epidemic of undifferentiated febrile illness. Post-mortem samples were obtained from two fatal infections...
  19. Hanafi H, Fryauff D, Saad M, Soliman A, Mohareb E, Medhat I, et al. Virus isolations and high population density implicate Culex antennatus (Becker) (Diptera: Culicidae) as a vector of Rift Valley Fever virus during an outbreak in the Nile Delta of Egypt. Acta Trop. 2011;119:119-24 pubmed publisher
    ..antennatus was the dominant species captured at the 2003 outbreak location in Kafr el Sheikh governorate. This is the first time that Cx. antennatus has been found naturally infected with RVFV in Egypt. ..
  20. Arishi H, Aqeel A, Al Hazmi M. Vertical transmission of fatal Rift Valley fever in a newborn. Ann Trop Paediatr. 2006;26:251-3 pubmed
    b>Rift Valley Fever (RVF) is a viral disease transmitted to humans by mosquito bite and contact with animals or their infected tissues...
  21. Reed C, Steele K, Honko A, Shamblin J, Hensley L, Smith D. Ultrastructural study of Rift Valley fever virus in the mouse model. Virology. 2012;431:58-70 pubmed publisher
    Detailed ultrastructural studies of Rift Valley fever virus (RVFV) in the mouse model are needed to develop and characterize a small animal model of RVF for the evaluation of potential vaccines and therapeutics...
  22. Dodd K, McElroy A, Jones M, Nichol S, Spiropoulou C. Rift Valley fever virus clearance and protection from neurologic disease are dependent on CD4+ T cell and virus-specific antibody responses. J Virol. 2013;87:6161-71 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes outbreaks of severe disease in people and livestock throughout Africa and the Arabian Peninsula...
  23. . Rift Valley fever outbreak--Kenya, November 2006-January 2007. MMWR Morb Mortal Wkly Rep. 2007;56:73-6 pubmed
    ..Of serum samples collected from the first 19 patients, Rift Valley fever (RVF) virus RNA or immunoglobulin M (IgM) antibodies against RVF virus were found in samples from 10 ..
  24. Elfadil A, Hasab Allah K, Dafa Allah O, Elmanea A. The persistence of rift valley fever in the Jazan region of Saudi Arabia. Rev Sci Tech. 2006;25:1131-6 pubmed
    A survey was conducted in the Jazan region of Saudi Arabia to investigate the presence of Rift Valley fever (RVF) in sheep and goats, by clinical identification of suspected herds and detection of immunoglobulin M (IgM) antibodies to RVF ..
  25. Jeanmaire E, Rabenarivahiny R, Biarmann M, Rabibisoa L, Ravaomanana F, Randriamparany T, et al. Prevalence of Rift Valley fever infection in ruminants in Madagascar after the 2008 outbreak. Vector Borne Zoonotic Dis. 2011;11:395-402 pubmed publisher
    A Rift Valley fever (RVF) outbreak occurred in Madagascar from January to May 2008...
  26. Kortekaas J, Oreshkova N, Cobos Jiménez V, Vloet R, Potgieter C, Moormann R. Creation of a nonspreading Rift Valley fever virus. J Virol. 2011;85:12622-30 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic bunyavirus of the genus Phlebovirus and a serious human and veterinary pathogen...
  27. Shieh W, Paddock C, Lederman E, Rao C, Gould L, Mohamed M, et al. Pathologic studies on suspect animal and human cases of Rift Valley fever from an outbreak in Eastern Africa, 2006-2007. Am J Trop Med Hyg. 2010;83:38-42 pubmed publisher
    b>Rift Valley fever (RVF) is an important viral zoonotic disease in Africa with periodic outbreaks associated with severe disease, death, and economic hardship...
  28. Abdo Salem S, Tran A, Grosbois V, Gerbier G, Al Qadasi M, Saeed K, et al. Can environmental and socioeconomic factors explain the recent emergence of Rift Valley fever in Yemen, 2000-2001?. Vector Borne Zoonotic Dis. 2011;11:773-9 pubmed publisher
    b>Rift Valley fever (RVF) is a major vector-borne zoonosis first identified on the African continent in the early 1900s. In 2000, RVF was reported for the first time in Yemen...
  29. Mohamed M, Mosha F, Mghamba J, Zaki S, Shieh W, Paweska J, et al. Epidemiologic and clinical aspects of a Rift Valley fever outbreak in humans in Tanzania, 2007. Am J Trop Med Hyg. 2010;83:22-7 pubmed publisher
    In January 2007, an outbreak of Rift Valley fever (RVF) was detected among humans in northern Tanzania districts...
  30. Rich K, Wanyoike F. An assessment of the regional and national socio-economic impacts of the 2007 Rift Valley fever outbreak in Kenya. Am J Trop Med Hyg. 2010;83:52-7 pubmed publisher
    Although Rift Valley fever (RVF) has significant impacts on human health and livestock production, it can also induce significant (and often overlooked) economic losses among various stakeholders in the marketing chain...
  31. Morrill J, Peters C. Protection of MP-12-vaccinated rhesus macaques against parenteral and aerosol challenge with virulent rift valley fever virus. J Infect Dis. 2011;204:229-36 pubmed publisher
    To test safety and efficacy of the Rift Valley fever MP-12 (RVF MP-12) vaccine, 9 healthy adult Rhesus macaques, weighing 5-10 kg, were inoculated intramuscularly with 6 × 10(3) plaque forming units (PFUs) of MP-12 vaccine...
  32. Smith D, Bird B, Lewis B, Johnston S, McCarthy S, Keeney A, et al. Development of a novel nonhuman primate model for Rift Valley fever. J Virol. 2012;86:2109-20 pubmed publisher
    b>Rift Valley fever (RVF) virus (RVFV) can cause severe human disease characterized by either acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome...
  33. Mandell R, Koukuntla R, Mogler L, Carzoli A, Freiberg A, Holbrook M, et al. A replication-incompetent Rift Valley fever vaccine: chimeric virus-like particles protect mice and rats against lethal challenge. Virology. 2010;397:187-98 pubmed publisher
    ..Here we demonstrate that chimeric VLPs containing Rift Valley fever virus (RVFV) glycoproteins G(N) and G(C), nucleoprotein N and the gag protein of Moloney murine leukemia ..
  34. Kading R, Crabtree M, Miller B. Inactivation of infectious virus and serological detection of virus antigen in Rift Valley fever virus-exposed mosquitoes fixed with paraformaldehyde. J Virol Methods. 2013;189:184-8 pubmed publisher
    ..particular regulatory importance for research involving viruses that are classified as select agents such as Rift Valley fever virus (RVFV)...
  35. Lagerqvist N, Näslund J, Lundkvist A, Bouloy M, Ahlm C, Bucht G. Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs. Virol J. 2009;6:6 pubmed publisher
    Affecting both livestock and humans, Rift Valley Fever is considered as one of the most important viral zoonoses in Africa. However, no licensed vaccines or effective treatments are yet available for human use...
  36. Soi R, Rurangirwa F, McGuire T, Rwambo P, Demartini J, Crawford T. Protection of sheep against Rift Valley fever virus and sheep poxvirus with a recombinant capripoxvirus vaccine. Clin Vaccine Immunol. 2010;17:1842-9 pubmed publisher
    b>Rift Valley fever (RVF) is an epizootic viral disease of sheep that can be transmitted from sheep to humans, particularly by contact with aborted fetuses...
  37. Kakani S, LaBeaud A, King C. Planning for Rift Valley fever virus: use of geographical information systems to estimate the human health threat of white-tailed deer (Odocoileus virginianus)-related transmission. Geospat Health. 2010;5:33-43 pubmed
    b>Rift Valley fever (RVF) virus is a mosquito-borne phlebovirus of the Bunyaviridae family that causes frequent outbreaks of severe animal and human disease in sub-Saharan Africa, Egypt and the Arabian Peninsula...
  38. Krida G, Diancourt L, Bouattour A, Rhim A, Chermiti B, Failloux A. [Assessment of the risk of introduction to Tunisia of the Rift Valley fever virus by the mosquito Culex pipiens]. Bull Soc Pathol Exot. 2011;104:250-9 pubmed publisher
    ..This leads to question about the potential risk of introducing another arbovirus, the Rift Valley fever (RVF) virus, in Tunisia from neighbouring countries where RVF circulates...
  39. Gould E, Higgs S. Impact of climate change and other factors on emerging arbovirus diseases. Trans R Soc Trop Med Hyg. 2009;103:109-21 pubmed publisher
    ..in northern Italy, the sudden appearance of West Nile virus in North America, the increasing frequency of Rift Valley fever epidemics in the Arabian Peninsula, and very recently, the emergence of Bluetongue virus in northern Europe...
  40. Carroll S, Reynes J, Khristova M, Andriamandimby S, Rollin P, Nichol S. Genetic evidence for Rift Valley fever outbreaks in Madagascar resulting from virus introductions from the East African mainland rather than enzootic maintenance. J Virol. 2011;85:6162-7 pubmed publisher
    b>Rift Valley fever virus (RVFV), a mosquito-borne phlebovirus, has been detected in Madagascar since 1979, with occasional outbreaks...
  41. Nguku P, Sharif S, Mutonga D, Amwayi S, Omolo J, Mohammed O, et al. An investigation of a major outbreak of Rift Valley fever in Kenya: 2006-2007. Am J Trop Med Hyg. 2010;83:5-13 pubmed publisher
    An outbreak of Rift Valley fever (RVF) occurred in Kenya during November 2006 through March 2007...
  42. Bird B, Nichol S. Breaking the chain: Rift Valley fever virus control via livestock vaccination. Curr Opin Virol. 2012;2:315-23 pubmed publisher
    b>Rift Valley fever virus is a mosquito-borne pathogen of livestock and humans that causes widespread and devastating outbreaks of severe and often fatal disease throughout Africa and portions of the Arabian Peninsula...
  43. Favier C, Chalvet Monfray K, Sabatier P, Lancelot R, Fontenille D, Dubois M. Rift Valley fever in West Africa: the role of space in endemicity. Trop Med Int Health. 2006;11:1878-88 pubmed
    b>Rift Valley fever is an endemic vector-borne disease in West Africa, which mainly affects domestic ruminants and occasionally humans. The aetiological mechanisms of its endemicity remain under debate...
  44. Bird B, Githinji J, Macharia J, Kasiiti J, Muriithi R, Gacheru S, et al. Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007. J Virol. 2008;82:11152-66 pubmed publisher
    b>Rift Valley fever (RVF) virus historically has caused widespread and extensive outbreaks of severe human and livestock disease throughout Africa, Madagascar, and the Arabian Peninsula...
  45. Martín Folgar R, Lorenzo G, Boshra H, Iglesias J, Mateos F, Borrego B, et al. Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization. MAbs. 2010;2:275-84 pubmed
    ..paper describes the generation of monoclonal antibodies directed to immunogenic nucleoprotein N epitopes of Rift Valley fever virus (RVFV), and their application in diagnostics, both for antibody detection in competitive ELISA and for ..
  46. Jost C, Nzietchueng S, Kihu S, Bett B, Njogu G, Swai E, et al. Epidemiological assessment of the Rift Valley fever outbreak in Kenya and Tanzania in 2006 and 2007. Am J Trop Med Hyg. 2010;83:65-72 pubmed publisher
    To capture lessons from the 2007 Rift Valley fever (RVF) outbreak, epidemiological studies were carried out in Kenya and Tanzania...
  47. Tantely M, Rakotoniaina J, Tata E, Andrianaivolambo L, Razafindrasata F, Fontenille D, et al. Biology of mosquitoes that are potential vectors of Rift Valley Fever virus in different biotopes of the central highlands of Madagascar. J Med Entomol. 2013;50:603-10 pubmed
    There were epidemic-epizootics of Rift Valley Fever (RVF) affecting humans and cattle in Madagascar in the district of Anjozorobe in 2008. Little is known about the role of Malagasy mosquitoes in the circulation of RVF virus...
  48. Bouloy M, Flick R. Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines. Antiviral Res. 2009;84:101-18 pubmed publisher
    ..review summarizes the successes and stumbling blocks in the development of reverse genetics technologies for Rift Valley fever virus and their application to the further dissection of its pathogenesis and the design of new therapeutics ..
  49. Mandell R, Koukuntla R, Mogler L, Carzoli A, Holbrook M, Martin B, et al. Novel suspension cell-based vaccine production systems for Rift Valley fever virus-like particles. J Virol Methods. 2010;169:259-68 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an arthropod-borne pathogen that often results in severe morbidity and mortality in both humans and livestock...
  50. Gray K, Worthy M, Juelich T, Agar S, Poussard A, Ragland D, et al. Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouse. PLoS Negl Trop Dis. 2012;6:e1529 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a major human and animal pathogen associated with severe disease including hemorrhagic fever or encephalitis...
  51. Linthicum K, Anyamba A, Tucker C, Kelley P, Myers M, Peters C. Climate and satellite indicators to forecast Rift Valley fever epidemics in Kenya. Science. 1999;285:397-400 pubmed
    All known Rift Valley fever virus outbreaks in East Africa from 1950 to May 1998, and probably earlier, followed periods of abnormally high rainfall...
  52. Clements A, Pfeiffer D, Martin V. Application of knowledge-driven spatial modelling approaches and uncertainty management to a study of Rift Valley fever in Africa. Int J Health Geogr. 2006;5:57 pubmed
    ..This is particularly relevant to Rift Valley fever (RVF), a zoonotic disease causing destructive outbreaks in livestock and man, as the geographical range of ..
  53. Crabtree M, Sang R, Lutomiah J, Richardson J, Miller B. Arbovirus surveillance of mosquitoes collected at sites of active Rift Valley fever virus transmission: Kenya, 2006-2007. J Med Entomol. 2009;46:961-4 pubmed
    Mosquitoes collected during an outbreak of Rift Valley fever in Kenya from December 2006 to February 2007 were tested to isolate other mosquito-borne arboviruses circulating in the region...
  54. von Teichman B, Engelbrecht A, Zulu G, Dungu B, Pardini A, Bouloy M. Safety and efficacy of Rift Valley fever Smithburn and Clone 13 vaccines in calves. Vaccine. 2011;29:5771-7 pubmed publisher
    Two modified live attenuated vaccines against the disease Rift Valley fever (RVF) have been tested for safety and efficacy in young calves...
  55. López Gil E, Lorenzo G, Hevia E, Borrego B, Eiden M, Groschup M, et al. A single immunization with MVA expressing GnGc glycoproteins promotes epitope-specific CD8+-T cell activation and protects immune-competent mice against a lethal RVFV infection. PLoS Negl Trop Dis. 2013;7:e2309 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne pathogen causing an important disease in ruminants often transmitted to humans after epizootic outbreaks in African and Arabian countries...
  56. Gerdes G. Rift valley fever. Vet Clin North Am Food Anim Pract. 2002;18:549-55 pubmed
    b>Rift Valley fever virus is an arthropod-borne Phlebovirus endemic in sub-Saharan Africa. Outbreaks also have occurred in Egypt, Madagascar, and most recently in the Arabian peninsula...
  57. Paweska J, Smith S, Wright I, Williams R, Cohen A, van Dijk A, et al. Indirect enzyme-linked immunosorbent assay for the detection of antibody against Rift Valley fever virus in domestic and wild ruminant sera. Onderstepoort J Vet Res. 2003;70:49-64 pubmed
    ..enzyme-linked immunosorbent assay (I-ELISA) for the detection of specific IgG immunoglobulins against Rift Valley fever virus (RVFV) was validated in-house...
  58. Fafetine J, Tijhaar E, Paweska J, Neves L, Hendriks J, Swanepoel R, et al. Cloning and expression of Rift Valley fever virus nucleocapsid (N) protein and evaluation of a N-protein based indirect ELISA for the detection of specific IgG and IgM antibodies in domestic ruminants. Vet Microbiol. 2007;121:29-38 pubmed
    Serodiagnosis of Rift Valley fever (RVF) currently relies on the use of live or inactivated whole virus as antigens...
  59. Paweska J, van Vuren P, Kemp A, Buss P, Bengis R, Gakuya F, et al. Recombinant nucleocapsid-based ELISA for detection of IgG antibody to Rift Valley fever virus in African buffalo. Vet Microbiol. 2008;127:21-8 pubmed
    Wild ruminants are thought to serve as natural hosts for Rift Valley fever virus (RVFV) but the role of these animals as reservoirs for RVFV during inter-epidemic periods and as amplifiers during epidemics is not well understood...
  60. Lorenzo G, Martín Folgar R, Hevia E, Boshra H, Brun A. Protection against lethal Rift Valley fever virus (RVFV) infection in transgenic IFNAR(-/-) mice induced by different DNA vaccination regimens. Vaccine. 2010;28:2937-44 pubmed publisher
    ..Interestingly, the combination of both vaccine constructs induced specific lymphoblast proliferation upon stimulation with a recombinant nucleoprotein...
  61. Mandell R, Flick R. Rift Valley fever virus: an unrecognized emerging threat?. Hum Vaccin. 2010;6:597-601 pubmed
    b>Rift Valley fever virus (RVFV) is an arthropod-borne pathogen that often results in severe morbidity and mortality in both humans and livestock...
  62. Dodd K, Bird B, Metcalfe M, Nichol S, Albarino C. Single-dose immunization with virus replicon particles confers rapid robust protection against Rift Valley fever virus challenge. J Virol. 2012;86:4204-12 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes outbreaks of severe disease in people and livestock throughout Africa and the Arabian Peninsula...
  63. Madani T, Al Mazrou Y, Al Jeffri M, Mishkhas A, Al Rabeah A, Turkistani A, et al. Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics. Clin Infect Dis. 2003;37:1084-92 pubmed
    This cohort descriptive study summarizes the epidemiological, clinical, and laboratory characteristics of the Rift Valley fever (RVF) epidemic that occurred in Saudi Arabia from 26 August 2000 through 22 September 2001...
  64. Chevalier V, Mondet B, Diaite A, Lancelot R, Fall A, Ponçon N. Exposure of sheep to mosquito bites: possible consequences for the transmission risk of Rift Valley Fever in Senegal. Med Vet Entomol. 2004;18:247-55 pubmed
    b>Rift Valley Fever (RVF) is a growing health problem in West Africa. In northern Senegal, the candidate vectors of this arbovirosis are Aedes (Aedimorphus) vexans Meigen and Culex (Culex) poicilipes Theobald (Diptera: Culicidae)...
  65. Gerdes G. Rift Valley fever. Rev Sci Tech. 2004;23:613-23 pubmed
    b>Rift Valley fever (RVF) is an arthropod-borne viral disease of ruminants, camels and humans...
  66. Turell M, Dohm D, Mores C, Terracina L, Wallette D, Hribar L, et al. Potential for North American mosquitoes to transmit Rift Valley fever virus. J Am Mosq Control Assoc. 2008;24:502-7 pubmed
    ..b>Rift Valley fever virus (RVFV) has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands ..
  67. Busquets N, Xavier F, Martín Folgar R, Lorenzo G, Galindo Cardiel I, del Val B, et al. Experimental infection of young adult European breed sheep with Rift Valley fever virus field isolates. Vector Borne Zoonotic Dis. 2010;10:689-96 pubmed publisher
    The increasing interest in Rift Valley fever virus (RVFV) and its potential impact on naive animal populations deserve revisiting experimental reproduction of RVFV infection, particularly in those animal breeds for which no data about ..
  68. Heinrich N, Saathoff E, Weller N, Clowes P, Kroidl I, Ntinginya E, et al. High seroprevalence of Rift Valley FEVER AND EVIDENCE FOR ENDEMIC circulation in Mbeya region, Tanzania, in a cross-sectional study. PLoS Negl Trop Dis. 2012;6:e1557 pubmed publisher
    The Rift Valley fever virus (RVFV) is an arthropod-borne phlebovirus. RVFV mostly causes outbreaks among domestic ruminants with a major economic impact. Human infections are associated with these events, with a fatality rate of 0.5-2%...
  69. Lernout T, Cardinale E, Jégo M, Despres P, Collet L, Zumbo B, et al. Rift valley fever in humans and animals in Mayotte, an endemic situation?. PLoS ONE. 2013;8:e74192 pubmed publisher
    Retrospective studies and surveillance on humans and animals revealed that Rift Valley Fever virus (RVFV) has been circulating on Mayotte for at least several years...
  70. Bird B, Ksiazek T, Nichol S, MacLachlan N. Rift Valley fever virus. J Am Vet Med Assoc. 2009;234:883-93 pubmed publisher
  71. Kamal S. Pathological studies on postvaccinal reactions of Rift Valley fever in goats. Virol J. 2009;6:94 pubmed publisher
    ..It could be concluded that the use of live attenuated vaccine of RVF (Smithburn strain) for immunization of live stock is not safe in Egypt as it considered an endemic area...
  72. Turell M, Wilson W, Bennett K. Potential for North American mosquitoes (Diptera: Culicidae) to transmit rift valley fever virus. J Med Entomol. 2010;47:884-9 pubmed
    To determine which arthropods should be targeted for control should Rift Valley fever virus (RVFV) be detected in North America, we evaluated Culex erraticus (Dyar and Knab), Culex erythrothorax Dyar, Culex nigripalpus Theobald, Culex ..
  73. Olive M, Goodman S, Reynes J. The role of wild mammals in the maintenance of Rift Valley fever virus. J Wildl Dis. 2012;48:241-66 pubmed
    b>Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting primarily domestic ruminants and humans. Numerous vector species are known or implicated in the transmission of RVFV...
  74. Chevalier V. Relevance of Rift Valley fever to public health in the European Union. Clin Microbiol Infect. 2013;19:705-8 pubmed publisher
    b>Rift Valley fever (RVF), a vector-borne zoonotic disease caused by a phlebovirus (family Bunyaviridae), is considered to be one of the most important viral zoonoses in Africa. It is also a potential bioterrorism agent...
  75. Sumaye R, Geubbels E, Mbeyela E, Berkvens D. Inter-epidemic transmission of Rift Valley fever in livestock in the Kilombero River Valley, Tanzania: a cross-sectional survey. PLoS Negl Trop Dis. 2013;7:e2356 pubmed publisher
    In recent years, evidence of Rift Valley fever (RVF) transmission during inter-epidemic periods in parts of Africa has increasingly been reported...
  76. Martin V, De Simone L, Lubroth J, Ceccato P, Chevalier V. Perspectives on using remotely-sensed imagery in predictive veterinary epidemiology and global early warning systems. Geospat Health. 2007;2:3-14 pubmed
    ..systems in predictive veterinary epidemiology and its integration into EWS, with a special focus on Rift Valley fever. It shows that, once fully validated in a country or region, this technology appears highly valuable and ..
  77. Ross T, Bhardwaj N, Bissel S, Hartman A, Smith D. Animal models of Rift Valley fever virus infection. Virus Res. 2012;163:417-23 pubmed publisher
    ..In this minireview, the current animal models used for one of these emerging infectious diseases, Rift Valley fever virus (RVFV), and the specifics of infection and pathology associated with each model are discussed.
  78. Ellenbecker M, Sears L, Li P, Lanchy J, Lodmell J. Characterization of RNA aptamers directed against the nucleocapsid protein of Rift Valley fever virus. Antiviral Res. 2012;93:330-9 pubmed publisher
    ..Finally, the aptamer RNAs were used to construct a sensitive fluorescence based sensor of N binding with potential applications for drug screening and imaging methodologies...
  79. Niu T, Gaff H, Papelis Y, Hartley D. An epidemiological model of Rift Valley fever with spatial dynamics. Comput Math Methods Med. 2012;2012:138757 pubmed publisher
    As a category A agent in the Center for Disease Control bioterrorism list, Rift Valley fever (RVF) is considered a major threat to the United States (USA)...
  80. Clements A, Pfeiffer D, Martin V, Pittliglio C, Best N, Thiongane Y. Spatial risk assessment of Rift Valley fever in Senegal. Vector Borne Zoonotic Dis. 2007;7:203-16 pubmed
    b>Rift Valley fever (RVF) is broadening its geographic range and is increasingly becoming a disease of global importance with potentially severe consequences for human and animal health...
  81. Pichlmair A, Habjan M, Unger H, Weber F. Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus. Vector Borne Zoonotic Dis. 2010;10:701-3 pubmed publisher
    b>Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, regularly accounts for large and severe outbreaks among humans and livestock in Africa and Arabia. Therefore, safe and efficient vaccines are highly needed...
  82. Moutailler S, Roche B, Thiberge J, Caro V, Rougeon F, Failloux A. Host alternation is necessary to maintain the genome stability of rift valley fever virus. PLoS Negl Trop Dis. 2011;5:e1156 pubmed publisher
    ..To test this hypothesis, we used Rift Valley fever virus (RVFV), an arbovirus that can be transmitted either directly (between vertebrates during the ..
  83. Gowen B, Bailey K, Scharton D, Vest Z, Westover J, Skirpstunas R, et al. Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge. Antiviral Res. 2013;98:135-43 pubmed publisher
    b>Rift Valley fever virus (RVFV) causes severe disease in humans and livestock. There are currently no approved antivirals or vaccines for the treatment or prevention of RVF disease in humans...
  84. Davies F, Kilelu E, Linthicum K, Pegram R. Patterns of Rift Valley fever activity in Zambia. Epidemiol Infect. 1992;108:185-91 pubmed
    An hypothesis that there was an annual emergence of Rift Valley fever virus in Zambia, during or after the seasonal rains, was examined with the aid of sentinel cattle...
  85. al Afaleq A, Abu Elzein E, Mousa S, Abbas A. A retrospective study of Rift Valley fever in Saudi Arabia. Rev Sci Tech. 2003;22:867-71 pubmed
    A retrospective study was undertaken to examine domestic ruminant sera for Rift Valley fever (RVF) virus antibodies. The sera were collected between 1992 and 1995 from cattle, sheep and goats from various locations in Saudi Arabia...
  86. Mondet B, Diaité A, Ndione J, Fall A, Chevalier V, Lancelot R, et al. Rainfall patterns and population dynamics of Aedes (Aedimorphus) vexans arabiensis, Patton 1905 (Diptera: Culicidae), a potential vector of Rift Valley Fever virus in Senegal. J Vector Ecol. 2005;30:102-6 pubmed
    ..of rainfall for the development of Aedes vexans arabiensis populations, one of the potential vectors of Rift Valley Fever in West Africa, was demonstrated in a two-year follow-up study conducted in the Ferlo region of Senegal...
  87. Evans A, Gakuya F, Paweska J, Rostal M, Akoolo L, Van Vuren P, et al. Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife. Epidemiol Infect. 2008;136:1261-9 pubmed
    b>Rift Valley fever virus (RVFV) is an arbovirus associated with periodic outbreaks, mostly on the African continent, of febrile disease accompanied by abortion in livestock, and a severe, fatal haemorrhagic syndrome in humans...
  88. Le Roux C, Kubo T, Grobbelaar A, van Vuren P, Weyer J, Nel L, et al. Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. J Clin Microbiol. 2009;47:645-51 pubmed publisher
    ..isothermal amplification assay (RT-LAMP) targeting the genomic large RNA segment of Rift Valley fever virus (RVFV)...
  89. Näslund J, Lagerqvist N, Habjan M, Lundkvist A, Evander M, Ahlm C, et al. Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus. Virology. 2009;385:409-15 pubmed publisher
    b>Rift Valley Fever virus (RVFV) regularly accounts for severe and often lethal outbreaks among livestock and humans in Africa. Safe and effective veterinarian and human vaccines are highly needed...
  90. Njenga M, Paweska J, Wanjala R, Rao C, Weiner M, Omballa V, et al. Using a field quantitative real-time PCR test to rapidly identify highly viremic rift valley fever cases. J Clin Microbiol. 2009;47:1166-71 pubmed publisher
    Approximately 8% of Rift Valley fever (RVF) cases develop severe disease, leading to hemorrhage, hepatitis, and/or encephalitis and resulting in up to 50% of deaths...
  91. Boshra H, Lorenzo G, Busquets N, Brun A. Rift valley fever: recent insights into pathogenesis and prevention. J Virol. 2011;85:6098-105 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a zoonotic pathogen that primarily affects ruminants but can also be lethal in humans. A negative-stranded RNA virus of the family Bunyaviridae, this pathogen is transmitted mainly via mosquito vectors...
  92. Kasari T, Carr D, Lynn T, Weaver J. Evaluation of pathways for release of Rift Valley fever virus into domestic ruminant livestock, ruminant wildlife, and human populations in the continental United States. J Am Vet Med Assoc. 2008;232:514-29 pubmed publisher
    To evaluate the feasibility for Rift Valley fever virus (RVFV) to enter the continental United States by various routes as well as to identify states in which domestic and wild ruminant and human populations would be most vulnerable to ..