japanese encephalitis

Summary

Summary: A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)

Top Publications

  1. Sapkal G, Wairagkar N, Ayachit V, Bondre V, Gore M. Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection. Am J Trop Med Hyg. 2007;77:1139-45 pubmed
    ..IgM capture ELISA showed recent Japanese encephalitis virus (JEV) infection...
  2. Zanin M, Webster D, Martin J, Wesselingh S. Japanese encephalitis vaccines: moving away from the mouse brain. Expert Rev Vaccines. 2003;2:407-16 pubmed
    b>Japanese encephalitis (JE) is a severe disease that is widespread throughout Asia and is spreading beyond its traditional boundaries...
  3. Ayukawa R, Fujimoto H, Ayabe M, Shoji H, Matsui R, Iwata Y, et al. An unexpected outbreak of Japanese encephalitis in the Chugoku district of Japan, 2002. Jpn J Infect Dis. 2004;57:63-6 pubmed
    Six patients unexpectedly presented with Japanese encephalitis (JE) from early August to mid-September 2002 in the Chugoku district of Japan. The mean age was 67...
  4. Rayamajhi A, Singh R, Prasad R, Khanal B, Singhi S. Study of Japanese encephalitis and other viral encephalitis in Nepali children. Pediatr Int. 2007;49:978-84 pubmed
    ..was conducted in children aged 1 month-14 years to identify the proportion of viral encephalitis due to Japanese encephalitis (JE) and compare the clinico-laboratory profile and outcome of JE with that of other viral encephalitis (..
  5. Biswas S, Kar S, Singh R, Chakraborty D, Vipat V, Raut C, et al. Immunomodulatory cytokines determine the outcome of Japanese encephalitis virus infection in mice. J Med Virol. 2010;82:304-10 pubmed publisher
    b>Japanese encephalitis virus (JEV) induces an acute infection of the central nervous system, the pathogenic mechanism of which is not fully understood...
  6. Wallace M, Smith D, Broom A, Mackenzie J, Hall R, Shellam G, et al. Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. J Gen Virol. 2003;84:1723-8 pubmed
    ..of flavivirus infection in vivo, we investigated the effect of passive immunization of mice with Japanese encephalitis virus (JE) antiserum on the outcome of infection with Murray Valley encephalitis virus (MVE)...
  7. Kabilan L, Rajendran R, Arunachalam N, Ramesh S, Srinivasan S, Samuel P, et al. Japanese encephalitis in India: an overview. Indian J Pediatr. 2004;71:609-15 pubmed
    b>Japanese encephalitis (JE)-epidemics have been reported in many parts of the country. The incidence has been reported to be high among pediatric group with high mortality...
  8. Touch S, Grundy J, Hills S, Rani M, Samnang C, Khalakdina A, et al. The rationale for integrated childhood meningoencephalitis surveillance: a case study from Cambodia. Bull World Health Organ. 2009;87:320-4 pubmed
    ..many Asian countries, however, the epidemiology and public health burden of neurological diseases such as Japanese encephalitis and bacterial meningitis are poorly understood...
  9. Verma S, Gupta N, Pattnaik P, Babu J, Rao P, Kumar S. Antibodies against refolded recombinant envelope protein (domain III) of Japanese encephalitis virus inhibit the JEV infection to Porcine Stable Kidney cells. Protein Pept Lett. 2009;16:1334-41 pubmed
    b>Japanese encephalitis virus (JEV) is a mosquito-borne viral zoonosis of public health importance. Global efforts have been made towards development of vaccine for prevention of Japanese encephalitis...

More Information

Publications111 found, 100 shown here

  1. Tani H, Shiokawa M, Kaname Y, Kambara H, Mori Y, Abe T, et al. Involvement of ceramide in the propagation of Japanese encephalitis virus. J Virol. 2010;84:2798-807 pubmed publisher
    b>Japanese encephalitis virus (JEV) is a mosquito-borne RNA virus and one of the most important flaviviruses in the medical and veterinary fields...
  2. Yang D, Kweon C, Kim B, Lim S, Kim S, Kwon J, et al. TaqMan reverse transcription polymerase chain reaction for the detection of Japanese encephalitis virus. J Vet Sci. 2004;5:345-51 pubmed
    ..reverse transcription polymerase chain reaction (RT-PCR) using TaqMan probe was developed for detection of Japanese encephalitis virus (JEV)...
  3. Dewasthaly S, Bhonde G, Shankarraman V, Biswas S, Ayachit V, Gore M. Chimeric T helper-B cell peptides induce protective response against Japanese encephalitis virus in mice. Protein Pept Lett. 2007;14:543-51 pubmed
    ..MAb binding and T helper cell stimulating peptide epitopes from structural and non-structural proteins of Japanese encephalitis virus were delineated...
  4. Vallée J, Dubot Pérès A, Ounaphom P, Sayavong C, Bryant J, Gonzalez J. Spatial distribution and risk factors of dengue and Japanese encephalitis virus infection in urban settings: the case of Vientiane, Lao PDR. Trop Med Int Health. 2009;14:1134-42 pubmed publisher
    ..The spatial distribution of flavivirus infection varies, even within a small city of less than 300,000 habitants such as Vientiane. ..
  5. Halstead S, Thomas S. Japanese encephalitis: new options for active immunization. Clin Infect Dis. 2010;50:1155-64 pubmed publisher
    b>Japanese encephalitis (JE) is a mosquito-borne flavivirus infection responsible for significant morbidity and mortality across Asia...
  6. Monath T, Guirakhoo F, Nichols R, Yoksan S, Schrader R, Murphy C, et al. Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antig. J Infect Dis. 2003;188:1213-30 pubmed
    ChimeriVax-JE is a live, attenuated vaccine against Japanese encephalitis, using yellow fever (YF) 17D vaccine as a vector. In a double-blind phase 2 trial, 99 adults received vaccine, placebo, or YF 17D vaccine (YF-VAX)...
  7. Konishi E, Shoda M, Kondo T. Analysis of yearly changes in levels of antibodies to Japanese encephalitis virus nonstructural 1 protein in racehorses in central Japan shows high levels of natural virus activity still exist. Vaccine. 2006;24:516-24 pubmed
    Recent reductions in numbers of human and equine Japanese encephalitis (JE) cases in Japan have seen calls to end JE vaccination...
  8. Bharati K, Vrati S. Japanese encephalitis: development of new candidate vaccines. Expert Rev Anti Infect Ther. 2006;4:313-24 pubmed
    b>Japanese encephalitis (JE) is the most common form of viral encephalitis that appears in the form of frequent epidemics of brain fever throughout Southeast Asia, China and India...
  9. Tauber E, Kollaritsch H, Korinek M, Rendi Wagner P, Jilma B, Firbas C, et al. Safety and immunogenicity of a Vero-cell-derived, inactivated Japanese encephalitis vaccine: a non-inferiority, phase III, randomised controlled trial. Lancet. 2007;370:1847-53 pubmed
    b>Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in southeast Asia. Although no treatment is currently available, vaccination effectively prevents the disease...
  10. Arunachalam N, Murty U, Narahari D, Balasubramanian A, Samuel P, Thenmozhi V, et al. Longitudinal studies of Japanese encephalitis virus infection in vector mosquitoes in Kurnool district, Andhra Pradesh, South India. J Med Entomol. 2009;46:633-9 pubmed
    ..carried out in Kurnool district, Andhra Pradesh state, south India, to identify the mosquito vectors of Japanese encephalitis virus (family Flaviviridae, genus Flavivirus, JEV)...
  11. Tauber E, Kollaritsch H, von Sonnenburg F, Lademann M, Jilma B, Firbas C, et al. Randomized, double-blind, placebo-controlled phase 3 trial of the safety and tolerability of IC51, an inactivated Japanese encephalitis vaccine. J Infect Dis. 2008;198:493-9 pubmed publisher
    b>Japanese encephalitis (JE) is the most important mosquito-borne viral encephalitis and has a high case fatality rate. It is caused by Japanese encephalitis virus...
  12. Fan J, Luo J, Chen L, Teng M, Bu D, Wang F, et al. Genetic analysis of strains of Japanese Encephalitis Virus isolated from swine in central China. Virus Genes. 2010;40:357-61 pubmed publisher
    In this study, four strains of Japanese Encephalitis Virus (JEV) were isolated from the cerebrospinal fluid of aborted fetuses or stillborn piglets collected randomly from a number of piggeries in central China...
  13. Keiser J, Maltese M, Erlanger T, Bos R, Tanner M, Singer B, et al. Effect of irrigated rice agriculture on Japanese encephalitis, including challenges and opportunities for integrated vector management. Acta Trop. 2005;95:40-57 pubmed
    b>Japanese encephalitis (JE) is a disease caused by an arbovirus that is spread by marsh birds, amplified by pigs, and mainly transmitted by the bite of infected Culex tritaeniorhynchus mosquitoes...
  14. Roy A, Tandon R, Agarwal S, Banerjee G. Seroprevalence of Japanese encephalitis virus infection in Lucknow, Uttar Pradesh. Indian J Med Res. 2006;124:211-2 pubmed
  15. Gould E, Solomon T. Pathogenic flaviviruses. Lancet. 2008;371:500-9 pubmed publisher
    ..mosquito-borne or tick-borne flaviviruses such as yellow fever, dengue, West Nile, St Louis encephalitis, Japanese encephalitis, tick-borne encephalitis, Kyasanur Forest disease, and Omsk haemorrhagic fever...
  16. Saini M, Vrati S. A Japanese encephalitis virus peptide present on Johnson grass mosaic virus-like particles induces virus-neutralizing antibodies and protects mice against lethal challenge. J Virol. 2003;77:3487-94 pubmed
    Protection against Japanese encephalitis virus (JEV) is antibody dependent, and neutralizing antibodies alone are sufficient to impart protection...
  17. Yang D, Kim B, Kweon C, Kwon J, Lim S, Han H. Biophysical characterization of Japanese encephalitis virus (KV1899) isolated from pigs in Korea. J Vet Sci. 2004;5:125-30 pubmed
    ..The isolate was further characterized by immuno-fluorescence assay using Japanese encephalitis virus (JEV) specific monoclonal antibodies...
  18. Li Y, Xu M, Chen L, Zhu J, Ye J, Liu X, et al. Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus. Vaccine. 2009;27:6004-10 pubmed publisher
    b>Japanese encephalitis (JE) is a serious infectious disease in southern and eastern Asia. Design and development of safer and more efficacious vaccines against Japanese encephalitis virus (JEV) is a high-priority target in the world...
  19. LAI C, Monath T. Chimeric flaviviruses: novel vaccines against dengue fever, tick-borne encephalitis, and Japanese encephalitis. Adv Virus Res. 2003;61:469-509 pubmed
    ..The chimeric flavivirus strategy has led to the rapid development of novel live-attenuated vaccines against dengue, TBE, JE, and West Nile viruses...
  20. Mishra M, Basu A. Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis. J Neurochem. 2008;105:1582-95 pubmed publisher
    ..b>Japanese encephalitis virus (JEV) is one of the most important causes of viral encephalitis worldwide...
  21. Wilder Smith A, Halstead S. Japanese encephalitis: update on vaccines and vaccine recommendations. Curr Opin Infect Dis. 2010;23:426-31 pubmed publisher
    b>Japanese encephalitis is the most common vaccine-preventable viral encephalitis in Asia...
  22. Tseng H, Tan H, Chang C, Huang W, Ho W. Seroepidemiology study of Japanese encephalitis neutralizing antibodies in southern Taiwan: a comparative study between urban city and country townships. Am J Infect Control. 2003;31:435-40 pubmed
    b>Japanese encephalitis (JE) occurs all over Asia, especially in southeastern regions...
  23. Hasegawa M, Tuno N, Yen N, Nam V, Takagi M. Influence of the distribution of host species on adult abundance of Japanese encephalitis vectors Culex vishnui subgroup and Culex gelidus in a rice-cultivating village in northern Vietnam. Am J Trop Med Hyg. 2008;78:159-68 pubmed
    ..A field study was conducted in a village in northern Vietnam to investigate how host distribution influences Japanese encephalitis (JE) vector abundance. Indoor and outdoor collections were conducted from 50 compounds...
  24. Konishi E, Shoda M, Kondo T. Prevalence of antibody to Japanese encephalitis virus nonstructural 1 protein among racehorses in Japan: indication of natural infection and need for continuous vaccination. Vaccine. 2004;22:1097-103 pubmed
    b>Japanese encephalitis virus (JEV) causes fatal diseases in equines as well as humans. In Japan, racehorses are vaccinated with inactivated JE vaccine every year and no equine JE cases have been reported since 1986...
  25. Kanojia P, Geevarghese G. New mosquito records of an area known for Japanese encephalitis hyperendemicity, Gorakhpur District, Uttar Pradesh, India. J Am Mosq Control Assoc. 2005;21:1-4 pubmed
    ..The impact of ecological changes on mosquito fauna in Gorakhpur District is discussed. The role of culicine mosquitoes in disease transmission in the area is highlighted. ..
  26. Kari K, Liu W, Gautama K, Mammen M, Clemens J, Nisalak A, et al. A hospital-based surveillance for Japanese encephalitis in Bali, Indonesia. BMC Med. 2006;4:8 pubmed
    b>Japanese encephalitis (JE) is presumed to be endemic throughout Asia, yet only a few cases have been reported in tropical Asian countries such as Indonesia, Malaysia and the Philippines...
  27. Wong S, Ooi M, Abdullah A, Wong S, Krishnan S, Tio P, et al. A decade of Japanese encephalitis surveillance in Sarawak, Malaysia: 1997-2006. Trop Med Int Health. 2008;13:52-5 pubmed publisher
    b>Japanese encephalitis virus (JEV) is an important encephalitis virus in Asia, but there are few data on Malaysia...
  28. Nerome R, Tajima S, Takasaki T, Yoshida T, Kotaki A, Lim C, et al. Molecular epidemiological analyses of Japanese encephalitis virus isolates from swine in Japan from 2002 to 2004. J Gen Virol. 2007;88:2762-8 pubmed
    To characterize Japanese encephalitis virus (JEV) strains recently prevalent in Japan, JEV surveillance was performed in pigs from 2002 to 2004...
  29. Das S, Basu A. Japanese encephalitis virus infects neural progenitor cells and decreases their proliferation. J Neurochem. 2008;106:1624-36 pubmed publisher
    b>Japanese encephalitis virus (JEV), a common cause of encephalitis in humans, especially in children, leads to substantial neuronal injury. The survivors of JEV infection have severe cognitive impairment, motor and behavioral disorders...
  30. Biswas S, Ayachit V, Sapkal G, Mahamuni S, Gore M. Japanese encephalitis virus produces a CD4+ Th2 response and associated immunoprotection in an adoptive-transfer murine model. J Gen Virol. 2009;90:818-26 pubmed publisher
    b>Japanese encephalitis is an acute infection of the central nervous system caused by Japanese encephalitis virus (JEV)...
  31. Turell M, O Guinn M, Wasieloski L, Dohm D, Lee W, Cho H, et al. Isolation of Japanese encephalitis and Getah viruses from mosquitoes (Diptera: Culicidae) collected near Camp Greaves, Gyonggi Province, Republic of Korea, 2000. J Med Entomol. 2003;40:580-4 pubmed
    ..by reverse transcriptase-polymerase chain reaction and sequencing and consisted of 14 isolations of Japanese encephalitis (JE) virus and one isolation of Getah (GET) virus...
  32. Yang S, Pan M, Tseng H, Liau M. The efficacy of mouse-brain inactivated Nakayama strain Japanese encephalitis vaccine--results from 30 years experience in Taiwan. Vaccine. 2006;24:2669-73 pubmed
    An intensive mandatory vaccination program has been underway, combating Japanese encephalitis (JE) since 1968 in Taiwan...
  33. Wierzba T, Ghimire P, Malla S, Banerjee M, Shrestha S, Khanal B, et al. Laboratory-based Japanese encephalitis surveillance in Nepal and the implications for a national immunization strategy. Am J Trop Med Hyg. 2008;78:1002-6 pubmed
    We report on two years of Japanese encephalitis (JE) surveillance in Nepal and the implications for a national immunization strategy. From May 2004 to April 2006, 4,652 patients with encephalitis were evaluated...
  34. Swami R, Ratho R, Mishra B, Singh M. Usefulness of RT-PCR for the diagnosis of Japanese encephalitis in clinical samples. Scand J Infect Dis. 2008;40:815-20 pubmed publisher
    ..in PGIMER, Chandigarh, India and aimed to compare IgM capture ELISA and nested RT-PCR for the diagnosis of Japanese encephalitis (JE)...
  35. Solomon T. Recent advances in Japanese encephalitis. J Neurovirol. 2003;9:274-83 pubmed
    b>Japanese encephalitis (JE), the most important cause of epidemic encephalitis worldwide, is confined to Asia, but its geographical area is spreading...
  36. Raung S, Chen S, Liao S, Chen J, Chen C. Tyrosine kinase inhibitors attenuate Japanese encephalitis virus-induced neurotoxicity. Biochem Biophys Res Commun. 2005;327:399-406 pubmed
    The cellular signaling molecules that underlie Japanese encephalitis virus (JEV)-induced inflammation and neurotoxicity are not well understood...
  37. Arakawa M, Yamashiro T, Uechi G, Tadano M, Nishizono A. Construction of human Fab (gamma1/kappa) library and identification of human monoclonal Fab possessing neutralizing potency against Japanese encephalitis virus. Microbiol Immunol. 2007;51:617-25 pubmed
    ..A combinatorial human Fab library was constructed using RNAs from peripheral blood lymphocytes obtained from Japanese encephalitis virus hyper-immune volunteers on pComb3H phagemid vector. The size of the constructed Fab library was 3...
  38. Nett R, Campbell G, Reisen W. Potential for the emergence of Japanese encephalitis virus in California. Vector Borne Zoonotic Dis. 2009;9:511-7 pubmed publisher
    The potential risk for the introduction and establishment of Japanese encephalitis virus (JEV) within California is described based on the literature...
  39. Schuh A, Li L, Tesh R, Innis B, Barrett A. Genetic characterization of early isolates of Japanese encephalitis virus: genotype II has been circulating since at least 1951. J Gen Virol. 2010;91:95-102 pubmed publisher
    b>Japanese encephalitis virus (JEV) consists of five genotypes (GI-V)...
  40. Wang J, Zhang H, Zhou J, Liang G. [Genotyping of Japanese encephalitis viruses isolated in Yunnan]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008;22:87-90 pubmed
    Explore the genotype of the epidemic Japanese encephalitis virus (JEV) in Yunnan Province from molecular level and to understand the molecular differences of the virus isolated from Yunnan at different time, locality and host...
  41. Lin C, Cheng C, Yang T, Li S, Cheng M, Wan L, et al. Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Res. 2008;137:49-55 pubmed publisher
    The interferon (IFN) antagonists of Japanese encephalitis virus (JEV) proteins contribute to the JE pathogenesis. Most flavivirus non-structural (NS) proteins correlate with virus-induced inflammation and immune escape...
  42. Liu W, Clemens J, Yang J, Xu Z. Immunization against Japanese encephalitis in China: a policy analysis. Vaccine. 2006;24:5178-82 pubmed
    This study examined the impact of Japanese encephalitis (JE) immunization policies on disease trends in China...
  43. Gao N, Chen W, Zheng Q, Fan D, Zhang J, Chen H, et al. Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination. Immunol Lett. 2010;129:23-31 pubmed publisher
    b>Japanese encephalitis virus (JEV) is an agent of Japanese encephalitis, and granulocyte-macrophage colony-stimulating factor (GM-CSF) is an attractive DNA vaccine adjuvant for its antigen presentation...
  44. Pandey B, Yamamoto A, Morita K, Kurosawa Y, Rai S, Adhikari S, et al. Serodiagnosis of Japanese encephalitis among Nepalese patients by the particle agglutination assay. Epidemiol Infect. 2003;131:881-5 pubmed
    b>Japanese encephalitis (JE) is a serious health problem in the southwestern region of Nepal. Serological diagnostic kits for routine diagnostic use in this region have not been available...
  45. Hombach J, Solomon T, Kurane I, Jacobson J, Wood D. Report on a WHO consultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines, WHO, Geneva, 2-3 September, 2004. Vaccine. 2005;23:5205-11 pubmed
    ..is undertaking consultations on immunological responses as parameters for evaluation and licensure of new Japanese encephalitis (JE) vaccines...
  46. Caramello P, Canta F, Balbiano R, Lipani F, Ariaudo S, De Agostini M, et al. Role of intravenous immunoglobulin administration in Japanese encephalitis. Clin Infect Dis. 2006;43:1620-1 pubmed
  47. Beasley D, Lewthwaite P, Solomon T. Current use and development of vaccines for Japanese encephalitis. Expert Opin Biol Ther. 2008;8:95-106 pubmed
    b>Japanese encephalitis (JE) is a significant cause of human morbidity and mortality throughout Asia...
  48. Saxena S, Mishra N, Saxena R, Singh M, Mathur A. Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties. J Infect Dev Ctries. 2009;3:517-30 pubmed
    In the year 2005, an epidemic of Japanese encephalitis (JE) occurred in the northern states of India...
  49. Misra U, Kalita J. Overview: Japanese encephalitis. Prog Neurobiol. 2010;91:108-20 pubmed publisher
    b>Japanese encephalitis (JE) is one of the most important endemic encephalitis in the world especially in Eastern and Southeastern Asia. JE affects over 50,000 patients and results in 15,000 deaths annually...
  50. Gupta N, Lomash V, Rao P. Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity. J Clin Virol. 2010;49:4-10 pubmed publisher
    Host immune response particularly through the induction of proinflammatory cytokines and chemokines in Japanese encephalitis virus infection has not been clearly understood in relation with pathogenicity and disease severity...
  51. Kalita J, Misra U, Pandey S, Dhole T. A comparison of clinical and radiological findings in adults and children with Japanese encephalitis. Arch Neurol. 2003;60:1760-4 pubmed
    b>Japanese encephalitis (JE) is the most common human endemic encephalitis, prevalent mainly in Southeast Asia...
  52. Chevalier V, de la Rocque S, Baldet T, Vial L, Roger F. Epidemiological processes involved in the emergence of vector-borne diseases: West Nile fever, Rift Valley fever, Japanese encephalitis and Crimean-Congo haemorrhagic fever. Rev Sci Tech. 2004;23:535-55 pubmed
    ..The objective of this paper is to describe the epidemiological processes of the vector-borne diseases Rift Valley fever, West Nile fever, Japanese encephalitis and Crimean-Congo haemorrhagic fever.
  53. Fujii Y, Kitaura K, Nakamichi K, Takasaki T, Suzuki R, Kurane I. Accumulation of T-cells with selected T-cell receptors in the brains of Japanese encephalitis virus-infected mice. Jpn J Infect Dis. 2008;61:40-8 pubmed
    b>Japanese encephalitis is a severe central nervous system (CNS) disease with a high case fatality rate in humans...
  54. Shrivastva A, Tripathi N, Parida M, Dash P, Jana A, Lakshmana Rao P. Comparison of a dipstick enzyme-linked immunosorbent assay with commercial assays for detection of Japanese encephalitis virus-specific IgM antibodies. J Postgrad Med. 2008;54:181-5 pubmed
    b>Japanese encephalitis (JE) is a major public health concern in Asia including India.
  55. Liu Y, Chuang C, Chen W. In situ reverse-transcription loop-mediated isothermal amplification (in situ RT-LAMP) for detection of Japanese encephalitis viral RNA in host cells. J Clin Virol. 2009;46:49-54 pubmed publisher
    Clinical diagnosis of Japanese encephalitis is usually difficult due to non-specific signs at the early and acute stages of the infection...
  56. Tang W, Ogawa M, Eshita Y, Aono H, Makino Y. Molecular evolution of Japanese encephalitis virus isolates from swine in Oita, Japan during 1980-2009. Infect Genet Evol. 2010;10:329-36 pubmed publisher
    In order to identify the patterns of genetic change of Japanese encephalitis virus (JEV) strains circulating in Oita, the complete envelope (E) gene has been sequenced for 35 isolates from swine in a 30-year span...
  57. Yun S, Cho J, Ju Y, Kim S, Ryou J, Han M, et al. Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005. Virol J. 2010;7:127 pubmed publisher
    We sequenced the envelope (E) gene of 17 strains of the Japanese encephalitis virus (JEV) isolated in South Korea in 1983-2005 and compared the sequences with those from previously reported strains...
  58. Yasui K. Neuropathogenesis of Japanese encephalitis virus. J Neurovirol. 2002;8 Suppl 2:112-4 pubmed
    In the central nervous system, the Japanese encephalitis virus can replicate only in neurons. The mechanism of the type of neurotropism was analyzed...
  59. Lin C, Changlia S, Huang C, Lin M, Yeh C. Positive Tc-99m TRODAT findings in Japanese encephalitis. Clin Nucl Med. 2007;32:484-5 pubmed
  60. Natividad F, Daroy M, Alonzo M, Matias R, Suarez L, Inoue S. Use of IgM-capture ELISA for confirmation of Japanese encephalitis infections in the Philippines. Southeast Asian J Trop Med Public Health. 2006;37 Suppl 3:136-9 pubmed
    ..with the Institute of Tropical Medicine of Nagasaki University in Japan, initiated a long-term study of Japanese encephalitis in the Philippines. Laboratory confirmation of acute cases of Japanese...
  61. Li P, Cao R, Zheng Q, Liu J, Li Y, Wang E, et al. Enhancement of humoral and cellular immunity in mice against Japanese encephalitis virus using a DNA prime-protein boost vaccine strategy. Vet J. 2010;183:210-6 pubmed publisher
    A synthetic multi-epitope gene containing critical epitopes of the Japanese encephalitis virus (JEV) envelope gene was cloned into both prokaryotic and eukaryotic expression vectors...
  62. Schuller E, Klade C, Wölfl G, Kaltenböck A, Dewasthaly S, Tauber E. Comparison of a single, high-dose vaccination regimen to the standard regimen for the investigational Japanese encephalitis vaccine, IC51: a randomized, observer-blind, controlled Phase 3 study. Vaccine. 2009;27:2188-93 pubmed publisher
    The standard administration of the investigational Japanese encephalitis vaccine IC51 is 2 doses of 6 microg with a 28-day interval...
  63. Aleyas A, Han Y, George J, Kim B, Kim K, Lee C, et al. Multifront assault on antigen presentation by Japanese encephalitis virus subverts CD8+ T cell responses. J Immunol. 2010;185:1429-41 pubmed publisher
    b>Japanese encephalitis virus (JEV) is a frequent cause of acute and epidemic viral encephalitis...
  64. Konishi E, Ajiro N, Nukuzuma C, Mason P, Kurane I. Comparison of protective efficacies of plasmid DNAs encoding Japanese encephalitis virus proteins that induce neutralizing antibody or cytotoxic T lymphocytes in mice. Vaccine. 2003;21:3675-83 pubmed
    Mice immunized with a plasmid DNA encoding the premembrane (prM) and envelope (E) proteins of Japanese encephalitis (JE) virus (designated pcJEME) produce neutralizing antibodies and are protected from JE...
  65. Kabilan L, Vrati S, Vrati S, Ramesh S, Srinivasan S, Appaiahgari M, et al. Japanese encephalitis virus (JEV) is an important cause of encephalitis among children in Cuddalore district, Tamil Nadu, India. J Clin Virol. 2004;31:153-9 pubmed
    b>Japanese encephalitis (JE) is endemic in Cuddalore district, Tamil Nadu (TN), Southern India. The reports of JE cases from the local hospitals did not reflect the actual disease burden...
  66. Pant G. A serological survey of pigs, horses, and ducks in Nepal for evidence of infection with Japanese encephalitis virus. Ann N Y Acad Sci. 2006;1081:124-9 pubmed
    b>Japanese encephalitis (JE) is an emerging disease of animals and humans in Nepal...
  67. Jmor F, Emsley H, Fischer M, Solomon T, Lewthwaite P. The incidence of acute encephalitis syndrome in Western industrialised and tropical countries. Virol J. 2008;5:134 pubmed publisher
    As part of efforts to control Japanese encephalitis (JE), the World Health Organization is producing a set of standards for JE surveillance, which require the identification of patients with acute encephalitis syndrome (AES)...
  68. Bharati K, Rani R, Vrati S. Evaluation of Japanese encephalitis virus DNA vaccine candidates in rhesus monkeys [Macaca mulatta]. Vaccine. 2009;27:10-6 pubmed publisher
    We have previously described DNA vaccine candidates against Japanese encephalitis virus (JEV) that were immunogenic in mice...
  69. Aleyas A, George J, Han Y, Rahman M, Kim S, Han S, et al. Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol. 2009;183:2462-74 pubmed publisher
    ..However, few reports describing the interactions of DCs with Japanese encephalitis virus (JEV), which remains the most frequent cause of acute and epidemic viral encephalitis, are available...
  70. Konishi E. Status of natural infection with Japanese encephalitis virus in Japan: prevalence of antibodies to the nonstructural 1 protein among humans and horses. Vaccine. 2009;27:7129-30 pubmed publisher
    The literature on natural infections with Japanese encephalitis virus in Japan and subclinical:clinical infection rates was summarized...
  71. Konishi E, Kitai Y, Tabei Y, Nishimura K, Harada S. Natural Japanese encephalitis virus infection among humans in west and east Japan shows the need to continue a vaccination program. Vaccine. 2010;28:2664-70 pubmed publisher
    b>Japanese encephalitis (JE) is a serious disease in Asia, but it can be prevented by vaccination...
  72. Lewthwaite P, Shankar M, Tio P, Daly J, Last A, Ravikumar R, et al. Evaluation of two commercially available ELISAs for the diagnosis of Japanese encephalitis applied to field samples. Trop Med Int Health. 2010;15:811-8 pubmed publisher
    To compare two commercially available kits, Japanese Encephalitis-Dengue IgM Combo ELISA (Panbio Diagnostics) and JEV-CheX IgM capture ELISA (XCyton Diagnostics Limited), to a reference standard (Universiti Malaysia Sarawak - Venture ..
  73. Kanojia P, Shetty P, Geevarghese G. A long-term study on vector abundance & seasonal prevalence in relation to the occurrence of Japanese encephalitis in Gorakhpur district, Uttar Pradesh. Indian J Med Res. 2003;117:104-10 pubmed
    b>Japanese encephalitis (JE) virus is an important cause of viral encephalitis in Gorakhpur district, UP. The area has been experiencing outbreaks of JE since 1978...
  74. Jamgaonkar A, Yergolkar P, Geevarghese G, Joshi G, Joshi M, Mishra A. Serological evidence for Japanese encephalitis virus and West Nile virus infections in water frequenting and terrestrial wild birds in Kolar District, Karnataka State, India. A retrospective study. Acta Virol. 2003;47:185-8 pubmed
    In a serological survey of birds in a Japanese encephalitis (JE) endemic area of Kolar District, Karnataka State, India, 859 bird sera were tested by hemagglutination-inhibition test (HIT) for JE encephalitis and West Nile encephalitis (..
  75. Hanna J, Smith G, McCulloch B, Taylor C, Pyke A, Brookes D. An assessment of the interval between booster doses of Japanese encephalitis vaccine in the Torres Strait. Aust N Z J Public Health. 2005;29:44-7 pubmed
    b>Japanese encephalitis (JE) emerged for the first time in the Torres Strait, north Australia, in 1995...
  76. Sebastian L, Desai A, Shampur M, Perumal Y, Sriram D, Vasanthapuram R. N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. Virol J. 2008;5:64 pubmed publisher
    ..Hence the present study was designed to evaluate the antiviral activity of 14 MIBT derivatives against Flaviviruses that are prevalent in India such as Japanese Encephalitis Virus (JEV), Dengue-2 (Den-2) and West Nile viruses (WNV).
  77. Mishra M, Kumawat K, Basu A. Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines. Cell Biol Int. 2008;32:1506-13 pubmed publisher
    ..We have shown that Japanese encephalitis virus (JEV) infection causes morphological and functional changes in astrocytic cell-lines...
  78. Yamada M, Nakamura K, Yoshii M, Kaku Y, Narita M. Brain lesions induced by experimental intranasal infection of Japanese encephalitis virus in piglets. J Comp Pathol. 2009;141:156-62 pubmed publisher
    ..encephalitis was experimentally induced in three-week-old piglets by a single intranasal inoculation of Japanese encephalitis virus (JEV) isolated from field pigs...
  79. van den Hurk A, Smith C, Field H, Smith I, Northill J, Taylor C, et al. Transmission of Japanese Encephalitis virus from the black flying fox, Pteropus alecto, to Culex annulirostris mosquitoes, despite the absence of detectable viremia. Am J Trop Med Hyg. 2009;81:457-62 pubmed
    To determine the potential role of flying foxes in transmission cycles of Japanese encephalitis virus (JEV) in Australia, we exposed Pteropus alecto (Megachiroptera: Pteropididae) to JEV via infected Culex annulirostris mosquitoes or ..
  80. Yamanaka A, Mulyatno K, Susilowati H, Hendrianto E, Utsumi T, Amin M, et al. Prevalence of antibodies to Japanese encephalitis virus among pigs in Bali and East Java, Indonesia, 2008. Jpn J Infect Dis. 2010;63:58-60 pubmed
    b>Japanese encephalitis virus (JEV) is a fatal disease in Asia. Pigs are considered to be the effective amplifying host for JEV in the peridomestic environment...
  81. Yin Z, Wang H, Yang J, Luo H, Li Y, Hadler S, et al. Japanese encephalitis disease burden and clinical features of Japanese encephalitis in four cities in the People's Republic of China. Am J Trop Med Hyg. 2010;83:766-73 pubmed publisher
    The incidence rate of Japanese encephalitis (JE) in the People's Republic of China has decreased substantially with the wide use of JE vaccine, but the accuracy of JE reporting is uncertain...
  82. Ritchie S, Pyke A, Smith G, Northill J, Hall R, van den Hurk A, et al. Field evaluation of a sentinel mosquito (Diptera: Culicidae) trap system to detect Japanese encephalitis in remote Australia. J Med Entomol. 2003;40:249-52 pubmed
    Incursions of Japanese encephalitis (JE) virus into northern Queensland are currently monitored using sentinel pigs...
  83. Nabeshima T, Mori A, Kozaki T, Iwata Y, Hidoh O, Harada S, et al. An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Japanese encephalitis vector mosquito, Culex tritaeniorhynchus. Biochem Biophys Res Commun. 2004;313:794-801 pubmed
    ..The F455W replacement in the Ace2 gene is solely responsible for the insecticide-insensitivity of AChE in TYM mosquitoes...
  84. Chuang C, Chiou S, Liang L, Chen W. Short report: detection of Japanese encephalitis virus in mouse peripheral blood mononuclear cells using an in situ reverse transcriptase-polymerase chain reaction. Am J Trop Med Hyg. 2003;69:648-51 pubmed
    b>Japanese encephalitis (JE) is an important mosquito-borne viral disease in Southeast Asia. Isolation of JE virus from peripheral blood is usually difficult because of transient and low titer of viremia...
  85. Xinglin J, Huanchun C, Xiang W, Changming Q. Quantitative and qualitative study of enzyme-linked immunosorbent assay to detect IgG against Japanese encephalitis virus in swine sera. Vet Res Commun. 2005;29:159-69 pubmed
    ..to investigate the application of indirect enzyme-linked immunoassay (ELISA) in detecting IgG against Japanese encephalitis virus in swine sera and the qualitative nature of this test...
  86. Handique S, Das R, Saharia B, Das P, Buragohain R, Saikia P. Coinfection of Japanese encephalitis with neurocysticercosis: an imaging study. AJNR Am J Neuroradiol. 2008;29:170-5 pubmed
    Coinfection of neurocysticercosis (NCC) and Japanese encephalitis (JE) has been advocated as more than a chance occurrence resulting in poor outcome...
  87. Srivastava V, Singh A, Thapar B. Field evaluation of malathion fogging against Japanese encephalitis vector, Culex tritaeniorhynchus. J Vector Borne Dis. 2008;45:249-50 pubmed
  88. Tauber E, Dewasthaly S. Japanese encephalitis vaccines--needs, flaws and achievements. Biol Chem. 2008;389:547-50 pubmed
    b>Japanese encephalitis causes serious health problems in countries in Southeast Asia, where the causative virus is endemic. Whereas most adults living in this region have acquired immunity, children are at high risk of infection...
  89. van den Hurk A, Ritchie S, Johansen C, Mackenzie J, Smith G. Domestic pigs and Japanese encephalitis virus infection, Australia. Emerg Infect Dis. 2008;14:1736-8 pubmed publisher
    To determine whether relocating domestic pigs, the amplifying host of Japanese encephalitis virus (JEV), decreased the risk for JEV transmission to humans in northern Australia, we collected mosquitoes for virus detection...
  90. Ompusunggu S, Hills S, Maha M, Moniaga V, Susilarini N, Widjaya A, et al. Confirmation of Japanese encephalitis as an endemic human disease through sentinel surveillance in Indonesia. Am J Trop Med Hyg. 2008;79:963-70 pubmed
    b>Japanese encephalitis (JE) results in significant mortality and disability in children in Asia. In Indonesia, despite recognition of JE virus transmission, reports of human disease have been few and from limited geographic areas...
  91. Gupta A, Lad V, Koshy A. Early death of Japanese encephalitis virus-infected mice administered a neutralizing cross-reactive monoclonal antibody against glycoprotein E. Acta Virol. 2009;53:191-5 pubmed
    ..auto-reactive (NHA-1 and NHA-2) monoclonal antibodies (MAbs) against glycoprotein E (gpE) of Japanese encephalitis virus (JEV) administered 1 day before or 2 days after intracerebral (i.c...
  92. Tiroumourougane S, Raghava P, Srinivasana S, Badrinath -. Management parameters affecting the outcome of Japanese encephalitis. J Trop Pediatr. 2003;49:153-6 pubmed publisher
    ..study was to identify the influence of various therapeutic measures on survival in children with Japanese encephalitis. Fluid restriction, avoidance of routine sedation and higher doses of mannitol were the basis of protocol ..