viloxazine

Summary

Summary: A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.

Top Publications

  1. Porsolt R, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730-2 pubmed
  2. Airaudo C, Bianchi C, Verdier M, Gayte Sorbier A. Comparative sorption of clomipramine, viloxazine, and maprotiline hydrochlorides in polyvinylchloride bags and glass vials. Clin Ther. 1992;14:192-5 pubmed
    The sorption of clomipramine, viloxazine, and maprotiline hydrochlorides was studied comparatively in polyvinylchloride (PVC) bags and glass flasks for up to 72 hours...
  3. Pisani F, Fazio A, Artesi C, Russo M, Trio R, Oteri G, et al. Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction. J Neurol Neurosurg Psychiatry. 1992;55:126-7 pubmed
    The effect of viloxazine (150-300 mg daily for 21 days) on plasma phenytoin levels at steady state was examined in 10 epileptic patients stabilised on a fixed phenytoin dosage...
  4. Airaudo C, Gayte Sorbier A, Bianchi C. Comparative study of the sorption of clomipramine and viloxazine hydrochlorides in Stedim 6 and PVC bags. Biomed Mater Eng. 1998;8:279-83 pubmed
    The stability of two antidepressant drugs, clomipramine and viloxazine hydrochlorides, was studied as was their possible sorption on Stedim 6, a new multilayer polyethylene-lined film, which was considered comparatively to polyvinyl ..
  5. Mitler M, Hajdukovic R. Relative efficacy of drugs for the treatment of sleepiness in narcolepsy. Sleep. 1991;14:218-20 pubmed
    ..Within this group of drugs, only methylphenidate and dextroamphetamine brought MWT sleep latencies to approximately 70% of normal levels. ..
  6. Candito M, Pringuey D, Souetre E, Salvati E, Halfon D, Chambon P, et al. [Circadian rhythm of plasma norepinephrine in depressive disorders. Preliminary study]. Encephale. 1987;13:341-7 pubmed
    ..This NA disinhibition could participate in the depressive desynchronisation and the potential relationships with sleep disorders must be discussed. ..
  7. Bouquet S, Vandel B, Guibert S, Lavoisy J. [Clinical pharmacokinetics of viloxazine chlorhydrate. Practical implications]. Encephale. 1989;15:443-7 pubmed
    ..b>Viloxazine is a second generation antidepressant drug with a short apparent half-life (T1/2 elim: 2 to 5 h (3...
  8. Dahl C, Gotestam K. An open field study of antidepressant drugs. Pharmacol Toxicol. 1989;64:302-7 pubmed
    ..For viloxazine, metapramine, piribedil and piracetam no significant dose effects were revealed at the doses tested...
  9. Saka C. Analytical Strategies for the Determination of Norepinephrine Reuptake Inhibitors in Pharmaceutical Formulations and Biological Fluids. Crit Rev Anal Chem. 2016;46:40-66 pubmed publisher
    ..NRIs are atomoxetine, reboxetine, viloxazine and maprotiline. NRIs with less activity at other sites are mazindol, bupropion, tapentadol, and teniloxazine...

More Information

Publications31

  1. Balsamo A, Lapucci A, Macchia M, Martinelli A, Nencetti S, Rossello A, et al. 2-(Methyleneaminoxy)methylmorpholine derivatives. Synthesis and antidepressant activity. Farmaco. 1994;49:77-82 pubmed
    The 3-(methyleneaminoxy)methylmorpholines 2 were synthesized as analogues of viloxazine 1, an antidepressant drug, in which the aryloxymethyl group is substituted by a (methyleneaminoxy)methyl moiety (MAOMM)...
  2. Libert M. [The use of viloxazine in the treatment of primary enuresis]. Acta Urol Belg. 1990;58:117-22 pubmed
    The use of Viloxazine (a non tricyclic antidepressant) could be a less toxic alternative to Imipramine (cardiotoxic tricyclic antidepressant) in the treatment of childhood primary enuresis...
  3. Matthews P, Horder J, Pearce M. Selective noradrenaline reuptake inhibitors for schizophrenia. Cochrane Database Syst Rev. 2018;1:CD010219 pubmed publisher
    ..The intervention NRI in nine of the 16 trials was reboxetine, with atomoxetine and viloxazine used in the remaining trials. 14 trials compared NRIs with placebo...
  4. Tan M, Castaldo E, Gao F, Chari R, Linehan D, Wright J, et al. A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables. J Am Coll Surg. 2008;206:857-68; discussion 868-9 pubmed publisher
    ..This study also indicates the need for new molecular tumor markers of prognosis to complement clinicopathologic markers if the goal of prediction of outcomes in individual patients is to be reached. ..
  5. Perault M, Griesemann E, Bouquet S, Lavoisy J, Vandel B. A study of the interaction of viloxazine with theophylline. Ther Drug Monit. 1989;11:520-2 pubmed
    The effect of viloxazine on the pharmacokinetics of theophylline was studied in eight healthy volunteers...
  6. Allain H, Lieury A, Brunet Bourgin F, Mirabaud C, Trebon P, Le Coz F, et al. Antidepressants and cognition: comparative effects of moclobemide, viloxazine and maprotiline. Psychopharmacology (Berl). 1992;106 Suppl:S56-61 pubmed
    The respective effects of three antidepressant drugs (moclobemide, 450 mg/j; viloxazine, 300 mg/j; maprotiline, 150 mg/j) on vigilance, attention, and memory were compared...
  7. Candito M, Pringuey D, Iordache A, Souetre E, Chambon P, Darcourt G. Circadian variation in total plasma tryptophan. Antidepressant treatment: drugs and phase advance. Life Sci. 1992;50:PL71-4 pubmed
    ..By contrast, in a previous study, moderately decreased tryptophan levels and a blunted amplitude in the circadian rhythm were observed in these same patients in a depressive phase. ..
  8. Thomare P, Bourin M, Kergueris M, Ortega A, Larousse C. Effects of administration route on pharmacokinetics of viloxazine in the rabbit. Methods Find Exp Clin Pharmacol. 1992;14:125-9 pubmed
    The absorption of viloxazine chlorhydrate was investigated in ten rabbits. Each animal received the drug (15 mg/kg) by three routes: intravenous, gastric and duodenal...
  9. Borromei A, Caramelli R, Conti M, Giancola L, Guerra L. [Nonpsychotic involutional inhibited depressions and psycho-organic deteriorations: treatment with Viloxazine and piracetam]. Minerva Med. 1989;80:475-82 pubmed
    ..This report claims that combined viloxazine-piracetam is the most appropriate treatment for involutional depression...
  10. Corral C, Lissavetzky J, Manzanares I, Darias V, Expósito Orta M, Martín Conde J, et al. Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs. Bioorg Med Chem. 1999;7:1349-59 pubmed
    A series of eight thienyloxymethylmorpholines, thiophene analogues of viloxazine, have been synthesized by three different routes...
  11. Chebili S, Abaoub A, Mezouane B, Le Goff J. [Antidepressants and sexual stimulation: the correlation]. Encephale. 1998;24:180-4 pubmed
    ..A double-blind study shows that viloxazine, an atypical antidepressant, could act specifically on sex drive by desinhibiting effect...
  12. Magnus R. A placebo controlled trial of viloxazine with and without tranquillizers in depressive illness. J Int Med Res. 1975;3:207-13 pubmed
    ..double-blind four-way crossover studies are reported, comparing the antidepressant effect of 14-day courses of: viloxazine, viloxazine with a tranquillizer either perphenazine or diazepam or tranquillizer alone, against a placebo...
  13. Leroi A, Lalaude O, Antonietti M, Touchais J, Ducrotte P, Menard J, et al. Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants. Neurogastroenterol Motil. 2000;12:149-54 pubmed
    ..Moreover, the number of HAPC was more markedly decreased in patients with constipation secondary to antidepressants than in patients with idiopathic constipation. ..
  14. Bouchard J, Strub N, Nil R. Citalopram and viloxazine in the treatment of depression by means of slow drop infusion. A double-blind comparative trial. J Affect Disord. 1997;46:51-8 pubmed
    Antidepressant efficacy and tolerability of citalopram and viloxazine were compared under double-blind conditions during the first two weeks of treatment with slow drop infusion, followed by oral administration for the rest of the six ..
  15. Leon C, Vigoya J, Conde S, Campo G, Castrillon E, Leon A. [Comparison of the effect of amisulpride and viloxazine in the treatment of dysthymia]. Acta Psiquiatr Psicol Am Lat. 1994;40:41-9 pubmed
    An evaluation of the therapeutic efficacy of Amisulpride as compared with Viloxazine in a group of patients diagnosed as dysthymic, according to the DSM-III-R criteria is presented...
  16. Altamura A, Mauri M, Girardi T, Panetta B. Alcoholism and depression: a placebo controlled study with viloxazine. Int J Clin Pharmacol Res. 1990;10:293-8 pubmed
    ..placebo-controlled study was planned to assess the antidepressant and attenuating drinking-behaviour efficacy of viloxazine (400 mg per os daily) versus a placebo in 30 dysthymic patients affected by alcohol dependence...
  17. Lestra C, D Amato T, Ghaemmaghami C, Perret Liaudet A, Broyer M, Renaud B, et al. Biological parameters in major depression: effects of paroxetine, viloxazine, moclobemide, and electroconvulsive therapy. Relation to early clinical outcome. Biol Psychiatry. 1998;44:274-80 pubmed
    ..and urinary biopterins were measured in 27 depressed patients before and during four different ATs (paroxetine, viloxazine, moclobemide, or electroconvulsive therapy)...
  18. Porsolt R, Lenegre A, Miguel S, Lavoisy J. Behavioral indices of beta receptor subsensitivity after chronic treatment with viloxazine in the mouse. Pharmacol Biochem Behav. 1990;37:567-70 pubmed
    The aim of the experiments was to determine whether chronic pretreatment with viloxazine decreased the sensitivity of mice to the sedative effects of a beta agonist clenbuterol...
  19. Kergueris M, Bourin M, Ribeyrol M, Beneroso N, Normand Y, Larousse C. Comparative pharmacokinetic study of conventional and sustained-release viloxazine in normal volunteers. Neuropsychobiology. 1989;20:136-40 pubmed
    Animal and human studies have indicated that viloxazine hydrochloride, an antidepressant drug with a half-life of 3-4 h in most subjects at low dosage, is rapidly and almost completely absorbed after oral administration...
  20. Airaudo C, Gayte Sorbier A, Bianchi C, Verdier M. Interactions between six psychotherapeutic drugs and plastic containers. Influence of plastic material and infusion solutions. Int J Clin Pharmacol Ther Toxicol. 1993;31:261-6 pubmed
    The interactions of chlorpromazine, clomipramine, maprotiline and viloxazine hydrochlorides, and of clorazepate dipotassium salt and diazepam with polyvinyl chloride (PVC) and Stedim 6 infusion bags were studied...
  21. Fritze J, Lanczik M, Sofic E, Struck M, Riederer P. Cholinergic neurotransmission seems not to be involved in depression but possibly in personality. J Psychiatry Neurosci. 1995;20:39-48 pubmed
    ..However, in the present double-blind studies (n = 20) with mianserin and viloxazine, respectively, which lack anticholinergic properties, adjunctive treatment with the anticholinergic biperiden ..
  22. Pisani F, Fazio A, Oteri G, Artesi C, Xiao B, Perucca E, et al. Effects of the antidepressant drug viloxazine on oxcarbazepine and its hydroxylated metabolites in patients with epilepsy. Acta Neurol Scand. 1994;90:130-2 pubmed
    The effects of Viloxazine (VLX, 100 mg b.i.d...