kidney cortex


Summary: The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.

Top Publications

  1. Lebkowska U, Janica J, Lebkowski W, Małyszko J, Lebkowski T, Leoniuk J, et al. Renal parenchyma perfusion spectrum and resistive index (RI) in ultrasound examinations with contrast medium in the early period after kidney transplantation. Transplant Proc. 2009;41:3024-7 pubmed publisher
    ..In conclusion, US-CM enhanced the efficacy of ultrasound diagnostics of the renal graft and may be used as a predictor of graft function in the early posttransplantation period...
  2. Geraldes P, Hiraoka Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009;15:1298-306 pubmed publisher
    ..These findings elucidate a new signaling pathway by which hyperglycemia can induce PDGF resistance and increase vascular cell apoptosis to cause diabetic vascular complications...
  3. Ventrella V, Elvir J, Borgatti A, Trigari G, Proverbio T, Pagliarani A, et al. Phosphorylated intermediate of the ouabain-insensitive, Na(+)-stimulated ATPase in rat kidney cortex and rainbow trout gills. Biochimie. 2010;92:128-35 pubmed publisher, we partially characterized the phosphorylated intermediate of the ouabain-insensitive Na-ATPase of rat kidney cortex homogenates and that of gill microsomes from freshwater rainbow trout...
  4. Wang L, Li J, Li J, Liu Z. Effects of lead and/or cadmium on the oxidative damage of rat kidney cortex mitochondria. Biol Trace Elem Res. 2010;137:69-78 pubmed publisher
    ..Ultrastructural observations and real-time quantitative PCR analyses were performed on kidney cortex pieces to identify the mitochondrial damage and quantify the relative expression levels of cytochrome oxidase ..
  5. Sabuhi R, Ali Q, Asghar M, Al Zamily N, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011;300:F700-6 pubmed publisher
    ..Furthermore, the protein levels of TNF-? and gp-91(phox) were higher in the kidney cortex of control obese rats...
  6. Blum J, Kinsey G, Monian P, Sun B, Cummings B, McHowat J, et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. Toxicol In Vitro. 2011;25:1001-6 pubmed publisher
    ..Thus, extensive FA release occurs during Ca(2+)-induced MPT, and that mitochondrial iPLA(2)? maintains mitochondrial arachidonic acid homeostasis under both basal and Ca(2+)-induced stress conditions...
  7. Samuel P, Ali Q, Sabuhi R, Wu Y, Hussain T. High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats. Am J Physiol Renal Physiol. 2012;303:F412-9 pubmed publisher
    ..protein and/or mRNA expression of angiotensinogen, renin, AT(1A/B)R, ACE, AT(2)R, ACE2, and MasR in the kidney cortex following 2 wk of a 8% high-sodium (HS) diet in lean and obese Zucker rats...
  8. Qi G, Lin M, Xu M, Manole C, Wang X, Zhu T. Telocytes in the human kidney cortex. J Cell Mol Med. 2012;16:3116-22 pubmed publisher
    ..We demonstrated the presence of TCs in human kidney cortex interstitium using primary cell culture, transmission electron microscopy (TEM) and in situ ..
  9. Zlender V, Breljak D, Ljubojevic M, Flajs D, Balen D, Brzica H, et al. Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicol Appl Pharmacol. 2009;239:284-96 pubmed publisher

More Information

Publications101 found, 100 shown here

  1. Barregard L, Fabricius Lagging E, Lundh T, Mölne J, Wallin M, Olausson M, et al. Cadmium, mercury, and lead in kidney cortex of living kidney donors: Impact of different exposure sources. Environ Res. 2010;110:47-54 pubmed publisher
    ..Assessment of metal concentrations in kidney biopsies from living subjects can be combined with information about exposure sources like smoking, diet, and occupation supplied by the biopsied subjects themselves...
  2. Haenisch S, Zimmermann U, Dazert E, Wruck C, Dazert P, Siegmund W, et al. Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex. Pharmacogenomics J. 2007;7:56-65 pubmed
    ..Their role in RCC cancer susceptibility or chemotherapy resistance needs further elucidation...
  3. Gojo A, Utsunomiya K, Taniguchi K, Yokota T, Ishizawa S, Kanazawa Y, et al. The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2007;568:242-7 pubmed
    ..We conclude that suppression of the Rho/Rho-kinase pathway could be a new strategy for the treatment of diabetic nephropathy...
  4. Uyanikgil Y, Ates U, Baka M, Biçer S, Oztaş E, Ergen G. Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex. Bull Environ Contam Toxicol. 2009;82:749-55 pubmed publisher
    This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight...
  5. Ishii N, Ikenaga H, Carmines P, Takada N, Okazaki T, Nagai T, et al. Impact of angiotensin-converting enzyme inhibition on renal cortical nitrotyrosine content during increased extracellular glucose concentration. Clin Biochem. 2006;39:633-9 pubmed
    ..Experiments evaluated the hypothesis that angiotensin-converting enzyme (ACE) inhibition suppresses hyperglycemia-induced nitrotyrosine (NT) production in the renal cortex...
  6. Van Itallie C, Rogan S, Yu A, Vidal L, Holmes J, Anderson J. Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol. 2006;291:F1288-99 pubmed
    ..We conclude that alternative splicing of claudin-10 generates unique permselectivities and might contribute to the variable paracellular transport observed along the nephron...
  7. Self M, Lagutin O, Bowling B, Hendrix J, Cai Y, Dressler G, et al. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006;25:5214-28 pubmed
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  8. Wesseling S, Joles J, van Goor H, Bluyssen H, Kemmeren P, Holstege F, et al. Transcriptome-based identification of pro- and antioxidative gene expression in kidney cortex of nitric oxide-depleted rats. Physiol Genomics. 2007;28:158-67 pubmed
    ..Interaction between NO synthesis and heme degradation pathways for blood pressure regulation was not found...
  9. Tilton R, Haidacher S, LeJeune W, Zhang X, Zhao Y, Kurosky A, et al. Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 2007;7:1729-42 pubmed
    ..These differentially regulated proteins create a foundation for a systems biology exploration of molecular mechanisms underlying the pathophysiology of diabetic nephropathy...
  10. Hruby G, Lehman D, Mitchell R, Marruffo F, Durak E, Pierorazio P, et al. Optimizing renal cortical neoplasm tissue sampling through a modified biopsy technique: laboratory experience and initial clinical experience. Urology. 2007;70:431-4 pubmed
    ..We then applied our laboratory findings to clinical practice to improve our biopsy results during laparoscopic renal cryoablation procedures...
  11. Estes A, Wong Y, Parker M, Sallee F, Balasubramaniam A, Parker S. Neuropeptide Y (NPY) Y2 receptors of rabbit kidney cortex are largely dimeric. Regul Pept. 2008;150:88-94 pubmed publisher
    The neuropeptide Y (NPY) Y2 receptors and the pancreatic polypeptide Y4 receptors from rabbit kidney cortex are isolated largely as approximately 180 kDa complexes constituted of one receptor dimer and one G-protein heterotrimer, similar ..
  12. Siddiqui A, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009;53:256-61 pubmed publisher
    ..that the PD treatment in obese rats caused an approximately 3-fold increase in the renin expression in the kidney cortex but had no effect on the expression of the cortical angiotensin II type 1 and AT(2) receptors...
  13. Kirk A, Campbell S, Bass P, Mason J, Collins J. Differential expression of claudin tight junction proteins in the human cortical nephron. Nephrol Dial Transplant. 2010;25:2107-19 pubmed publisher
    ..A survey of claudin staining was performed on human kidney cortex embedded in glycolmethacrylate resin to enhance tissue morphology and facilitate the cutting of 2 microm ..
  14. Nakamaki S, Satoh H, Kudoh A, Hayashi Y, Hirai H, Watanabe T. Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats. Exp Biol Med (Maywood). 2011;236:614-20 pubmed publisher
    ..Thus, over-expression of adiponectin has beneficial effects on early stage diabetic nephropathy. ..
  15. Yallowitz A, Hrycaj S, Short K, Smyth I, Wellik D. Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS ONE. 2011;6:e23410 pubmed publisher
  16. Tandogan B, Guvenc A, Calis I, Ulusu N. In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase. Acta Biochim Pol. 2011;58:471-5 pubmed
    ..These compounds inhibited bovine kidney cortex GR in a concentration-dependent manner. Kinetic characterization of the inhibition was also performed.
  17. Halleck F, Diederichs G, Koehlitz T, Slowinski T, Engelken F, Liefeldt L, et al. Volume matters: CT-based renal cortex volume measurement in the evaluation of living kidney donors. Transpl Int. 2013;26:1208-16 pubmed publisher
    ..83; P < 0.001) and the recipient (r = 0.75; P < 0.001). In conclusion CT-based assessment of renal cortex volume bears the potential to substitute existing methods to assess pre-transplant living donor split renal function. ..
  18. Cobanova K, Faix S, Placha I, Mihaliková K, Varádyová Z, Kisidayová S, et al. Effects of Different Dietary Selenium Sources on Antioxidant Status and Blood Phagocytic Activity in Sheep. Biol Trace Elem Res. 2017;175:339-346 pubmed publisher
    ..No differences appeared between tissue Se contents in the liver and kidney cortex due to the source of added Se...
  19. Collins J, Scheving L, Ghishan F. Decreased transcription of the sodium-phosphate transporter gene in the hypophosphatemic mouse. Am J Physiol. 1995;269:F439-48 pubmed
    ..5-fold (Hyp/normal = 0.22 +/- 0.04, n = 3, P < 0.05). Additionally, immunohistochemical analysis of kidney cortex in both mice localized the protein to the apical membrane of the proximal tubules...
  20. Wahab S, Ahmad Khan R, Thapa M, Wahab A, Ahmad I. Giant angiomyolipoma associated with a dilated vessel prone to hemorrhage. Iran J Kidney Dis. 2009;3:168-71 pubmed
    ..Although mostly asymptomatic, they can be a cause of significant morbidity due to size and hemorrhage. We report a case of giant angiomyolipoma with a dilated vessel susceptible to hemorrhage. ..
  21. Christensen B, Perrier R, Wang Q, Zuber A, Maillard M, Mordasini D, et al. Sodium and potassium balance depends on ?ENaC expression in connecting tubule. J Am Soc Nephrol. 2010;21:1942-51 pubmed publisher
    ..In summary, ?ENaC expression within the CNT/CD is crucial for sodium and potassium homeostasis and causes signs and symptoms of pseudohypoaldosteronism type 1 if missing. ..
  22. Tain Y, Hsu C, Lin C, Huang L, Lau Y. Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats. Eur J Pharmacol. 2011;670:561-5 pubmed publisher
    ..Our findings suggest that aliskiren is a therapeutic agent for prehypertension that regulates the ADMA/NO pathway. ..
  23. Li X, Chen X, Yao J, Zhang X, Tian J. Renal cortex segmentation using optimal surface search with novel graph construction. Med Image Comput Comput Assist Interv. 2011;14:387-94 pubmed
    ..The true positive volume fraction (TPVF) and false positive volume fraction (FPVF) are 74.10% and 0.08%, respectively. The experimental results demonstrate the effectiveness of the proposed method. ..
  24. Yingst D, Araghi A, Doci T, Mattingly R, Beierwaltes W. Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism. Am J Physiol Renal Physiol. 2009;297:F1324-9 pubmed publisher
    To understand how rapid changes in blood pressure can regulate Na-K-ATPase in the kidney cortex, we tested the hypothesis that a short-term (5 min) decrease in renal perfusion pressure will increase the amount of Na-K-ATPase in the ..
  25. Liu Y, Echtermeyer F, Thilo F, Theilmeier G, Schmidt A, Schulein R, et al. The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling. Arterioscler Thromb Vasc Biol. 2012;32:378-85 pubmed publisher
    ..Our results establish a previously unknown function of Sdc4 for regulation of TRPC6 channels and support the role of Sdc4 for the regulation of glomerular permeability. ..
  26. Maguire D, Turton J, Scudamore C, Swain A, McClure F, Smyth R, et al. Correlation of histopathology, urinary biomarkers, and gene expression responses following hexachloro-1:3-butadiene-induced acute nephrotoxicity in male Hanover Wistar rats: a 28-day time course study. Toxicol Pathol. 2013;41:779-94 pubmed publisher
  27. Casare F, Milan D, Fernandez R. Stimulation of calcium-sensing receptor increases biochemical H?-ATPase activity in mouse cortex and outer medullary regions. Can J Physiol Pharmacol. 2014;92:181-8 pubmed publisher
    ..In summary, CaSR stimulation enhances the biochemical activity of V-ATPase and gastric H(+)/K(+)-ATPase in both the cortical and outer medullary region of mouse kidney. ..
  28. Wassenberg T, Willemsen M, Geurtz P, Lammens M, Verrijp K, Wilmer M, et al. Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox. Mol Genet Metab. 2010;101:349-56 pubmed publisher
    ..CYP2D6-mediated conversion of tyramine into dopamine might be an interesting target for the development of new therapeutic strategies in AADC-deficiency. ..
  29. Harraz A, Helmy T, Taha D, Shalaby I, Sarhan O, Dawaba M, et al. Changes in differential renal function after pyeloplasty in children. J Urol. 2013;190:1468-73 pubmed publisher
    ..Renal function improves after pyeloplasty in children. Baseline differential renal function and cortical thickness predict improvement after surgery. ..
  30. Scholtz J, Wichmann J, Hüsers K, Beeres M, Nour Eldin N, Frellesen C, et al. Automated tube voltage adaptation in combination with advanced modeled iterative reconstruction in thoracoabdominal third-generation 192-slice dual-source computed tomography: effects on image quality and radiation dose. Acad Radiol. 2015;22:1081-7 pubmed publisher
    ..9% compared to 128-slice DSCT. ..
  31. Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C. Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock. 2011;36:83-9 pubmed publisher
    ..Taken in conjunction with the decrease in urine output, our results could represent either a functional renal impairment or an adaptive response. ..
  32. Goyenechea E, Andrade F, de las Heras J, Lage S, Prieto J, Ruiz N, et al. Expression of proinflammatory factors in renal cortex induced by methylmalonic acid. Ren Fail. 2012;34:885-91 pubmed publisher
    ..After 1 month of MMA injections, expression levels of SIRT1 were not affected, suggesting mitochondrial preservation in early stages of the disease. ..
  33. Sataranatarajan K, Feliers D, Mariappan M, Lee H, Lee M, Day R, et al. Molecular events in matrix protein metabolism in the aging kidney. Aging Cell. 2012;11:1065-73 pubmed publisher
    ..Age-phase-specific regulation of matrix protein synthesis occurs and involves matrix protein-specific transcriptional and post-transcriptional mechanisms. ..
  34. Tandogan B, Ulusu N. Purification and kinetics of bovine kidney cortex glutathione reductase. Protein Pept Lett. 2010;17:667-74 pubmed
    Glutathione reductase was purified 34806-fold with a final yield of 85 % from the bovine kidney cortex. Some molecular and kinetic properties of purified enzyme are investigated...
  35. Li C, Cai F, Yang Y, Zhao X, Wang C, Li J, et al. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway. Eur J Pharmacol. 2010;649:382-9 pubmed publisher
    ..These findings indicate that the protective mechanisms of TSG on diabetic nephropathy are involved in the alleviation of oxidative stress injury and overexpression of COX-2 and TGF-?1, partially via activation of SIRT1. ..
  36. Wang Y, Sun Z. Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J Hypertens. 2014;32:1629-36; discussion 1636 pubmed publisher
    ..ETB receptor protein expression was decreased in both kidney cortex and medulla of SHRs...
  37. Barbati A, Cappuccini B, Aisa M, Grasselli C, Zamarra M, Bini V, et al. Increased Urinary Cystatin-C Levels Correlate with Reduced Renal Volumes in Neonates with Intrauterine Growth Restriction. Neonatology. 2016;109:154-60 pubmed publisher
    ..It also could be used as an early biochemical marker to identify IUGR neonates at high risk of developing long-term renal disease and to select patients for monitoring during childhood. ..
  38. Rule A, Amer H, Cornell L, Taler S, Cosio F, Kremers W, et al. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med. 2010;152:561-7 pubmed publisher
    ..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...
  39. Erdorf M, Seifert R. Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:357-72 pubmed publisher
    ..Thus, potent and selective AC5 inhibitors could constitute a novel approach to treat PKD. ..
  40. Shimizu H, Saito S, Higashiyama Y, Nishijima F, Niwa T. CREB, NF-?B, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells. Am J Physiol Cell Physiol. 2013;304:C685-92 pubmed publisher
    ..Taken together, CREB, NF-?B, and NOX4 coordinately upregulate indoxyl sulfate-induced AGT expression in proximal tubular cells. ..
  41. Sejima T, Yamaguchi N, Iwamoto H, Masago T, Morizane S, Ono K, et al. The Utility of the Remnant Kidney Volume/Body Surface Area Ratio and Tumor Diameter as Predictors of Postoperative Degree of Renal Functional Decline in Patients With Renal Cell Carcinoma Treated by Radical Nephrectomy. Urology. 2015;86:307-11 pubmed publisher
    ..S-decline) renal functional decline and to elucidate the histopathologic features of the resected normal kidney cortex, as well as the occurrence of cardiovascular disease (CVD) in both M-decline and S-decline patients...
  42. Shihab F, Bennett W, Andoh T. Role of cellular cholesterol in pharmacologic preconditioning with cyclosporine in experimental kidney transplantation. Am J Nephrol. 2010;31:134-40 pubmed publisher
    ..Thus, use of statins around the time of transplantation may need to be evaluated until further studies are conducted to determine the clinical relevance of this observation. ..
  43. Albiston A, Yeatman H, Pham V, Fuller S, Diwakarla S, Fernando R, et al. Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney. Regul Pept. 2011;166:83-9 pubmed publisher
    ..Based on our results, we propose that GLUT4 plays a role in shunting glucose across epithelial cells. In the kidney cortex, IRAP, in concert with other peptidases, may be important in the generation of free amino acids for uptake, ..
  44. Nilsson L, Madsen K, Topcu S, Jensen B, Frøkiær J, Nørregaard R. Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse. Am J Physiol Renal Physiol. 2012;302:F1430-9 pubmed publisher
    ..In conclusion, COX-2-derived prostaglandins contribute to downregulation of transcellular water transporters in the collecting duct and likely to postobstruction diureses in the mouse. ..
  45. Henry S, Johnson M, Zanardi T, Fey R, Auyeung D, Lappin P, et al. Renal uptake and tolerability of a 2'-O-methoxyethyl modified antisense oligonucleotide (ISIS 113715) in monkey. Toxicology. 2012;301:13-20 pubmed publisher
    The primary target organ for uptake of systemically administered phosphorothioate oligonucleotides is the kidney cortex and the proximal tubular epithelium in particular...
  46. Songib N, Nazri M, Yaakup N, Nor H, Sun Z. Multiphase renal CT in the evaluation of renal masses: is the nephrographic phase necessary?. Clin Imaging. 2013;37:1037-42 pubmed publisher
    ..A three-phase CT (plain, corticomedullary, and excretory phase) is therefore adequate in the clinical diagnosis of renal lesions. ..
  47. Prieto M, Gonzalez Villalobos R, Botros F, Martin V, Pagan J, Satou R, et al. Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am J Physiol Renal Physiol. 2011;300:F749-55 pubmed publisher
  48. Law A, Wong C, Turner J, Gonzalez A, Prieto M, Wagner G. Vasopressin controls stanniocalcin-1 gene expression in rat and mouse kidney. Mol Cell Endocrinol. 2012;348:183-8 pubmed publisher
    ..The findings serve to further implicate STC-1 in the renal control of ECF balance. ..
  49. Chowdhury A, Cox E, Francis S, Lobo D. A randomized, controlled, double-blind crossover study on the effects of 1-L infusions of 6% hydroxyethyl starch suspended in 0.9% saline (voluven) and a balanced solution (Plasma Volume Redibag) on blood volume, renal blood flow velocity, and renal . Ann Surg. 2014;259:881-7 pubmed publisher
    ..The balanced starch produced an increase in renal cortical tissue perfusion, a phenomenon not seen with starch in 0.9% saline. ..
  50. Miura N. Individual susceptibility to cadmium toxicity and metallothionein gene polymorphisms: with references to current status of occupational cadmium exposure. Ind Health. 2009;47:487-94 pubmed
    ..This article describes the strategy method for analyzing individual susceptibility to cadmium toxicity and genetic polymorphisms of metallothionein, with reference to the current status of occupational cadmium exposure. ..
  51. Asavapanumas N, Kittayaruksakul S, Meetam P, Muanprasat C, Chatsudthipong V, Soodvilai S. Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPAR?-independent pathways. Drug Metab Pharmacokinet. 2012;27:513-9 pubmed
    ..Taken together, our data showed that fenofibrate decreased the activity of OCT2 by reducing the number of functional transporters on the membrane, which is likely to be a PPAR?-independent pathway. ..
  52. Jouret F, Walrand S, Parreira K, Courtoy P, Pauwels S, Devuyst O, et al. Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice. Am J Physiol Renal Physiol. 2010;298:F454-60 pubmed publisher
    ..These data show that SPECT imaging with well-validated radiotracers allows in vivo investigations of specific proximal tubule functions in conscious mice...
  53. Turner J, Xiang F, Feng Q, Wagner G. The renal stanniocalcin-1 gene is differentially regulated by hypertonicity and hypovolemia in the rat. Mol Cell Endocrinol. 2011;331:150-7 pubmed publisher
    ..The findings are therefore indicative of cortical and medullary STC-1 having separate roles in the renal control of ECF balance...
  54. Leinonen M, Raekallio M, Vainio O, Ruohoniemi M, Biller D, O Brien R. Quantitative contrast-enhanced ultrasonographic analysis of perfusion in the kidneys, liver, pancreas, small intestine, and mesenteric lymph nodes in healthy cats. Am J Vet Res. 2010;71:1305-11 pubmed publisher
    ..To evaluate perfusion of abdominal organs in healthy cats by use of contrast-enhanced ultrasonography...
  55. Yamamoto M, Horinouchi H, Kobayashi K, Seishi Y, Sato N, Itoh M, et al. Fluid resuscitation of hemorrhagic shock with hemoglobin vesicles in Beagle dogs: pilot study. Artif Cells Blood Substit Immobil Biotechnol. 2012;40:179-95 pubmed publisher
    ..Serum chemistry data from the HbV group were unremarkable. HbV contributed 32% of the post-resuscitation oxygen delivery. Collectively, HbV is comparable to ASB and HSA as a resuscitation fluid and is an effective oxygen carrier...
  56. Kamiyama M, Farragut K, Garner M, Navar L, Kobori H. Divergent localization of angiotensinogen mRNA and protein in proximal tubule segments of normal rat kidney. J Hypertens. 2012;30:2365-72 pubmed publisher
    ..To determine the detailed localization of angiotensinogen in the three proximal tubule segments, we established multistaining methods using segment-specific protein markers...
  57. Roth R, Parikh S, Makey D, Foster J, Rozenblit G, Satoskar A, et al. When size matters: diagnostic value of kidney biopsy according to the gauge of the biopsy needle. Am J Nephrol. 2013;37:249-54 pubmed publisher
    ..Herein we report the diagnostic value of kidney biopsies according to the size of the biopsy needles...
  58. Schauer K, Freund D, Prenni J, Curthoys N. Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis. Am J Physiol Renal Physiol. 2013;305:F628-40 pubmed publisher
    ..Proximal convoluted tubule cells were isolated from rat kidney cortex at various times after onset of acidosis and fractionated to separate the soluble cytosolic proteins from the ..
  59. Schneider A, Goodwin M, Schelleman A, Bailey M, Johnson L, Bellomo R. Contrast-enhanced ultrasound to evaluate changes in renal cortical perfusion around cardiac surgery: a pilot study. Crit Care. 2013;17:R138 pubmed publisher
    ..We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value in the assessment of renal cortical perfusion in the peri-operative period in cardiac surgery patients...
  60. Schneider R, Meusel M, Renker S, Bauer C, Holzinger H, Roeder M, et al. Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome. Am J Physiol Renal Physiol. 2009;297:F1614-21 pubmed publisher
    ..In accordance to the decreased PAH net secretion, renal excretion of an endogenous organic anion (PGE(2)) is also impaired after ischemia and reperfusion...
  61. McEneaney V, Dooley R, Harvey B, Thomas W. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. J Steroid Biochem Mol Biol. 2010;118:18-28 pubmed publisher
    ..This sub-cellular distribution of ERK1/2 was inhibited in cells suppressed in the expression of PKD1. ..
  62. Tandogan B, Ulusu N. Comparative in vitro effects of some metal ions on bovine kidney cortex glutathione reductase. Prep Biochem Biotechnol. 2010;40:405-11 pubmed publisher
    ..In this study we have tested effects of the some metal ions on the purified bovine kidney cortex glutathione reductase (GR)...
  63. Francescato H, Marin E, Cunha F, Costa R, Silva C, Coimbra T. Role of endogenous hydrogen sulfide on renal damage induced by adriamycin injection. Arch Toxicol. 2011;85:1597-606 pubmed publisher
    ..All these alterations were reduced by PAG injection. The protective effect of PAG on ADR nephrotoxicity was associated to decreased H?S formation and to restriction of oxidative stress and inflammation in the renal cortex...
  64. Rashed L, Hashem R, Soliman H. Oxytocin inhibits NADPH oxidase and P38 MAPK in cisplatin-induced nephrotoxicity. Biomed Pharmacother. 2011;65:474-80 pubmed publisher
    ..In conclusion OT has a powerful antioxidant effect that can alleviate the CP-induced nephrotoxicity through inhibition of NADPH oxidase and P38 MAPK resulting in improvement of kidney functions...
  65. Ritter J, Li C, Xia M, Poklis J, Lichtman A, Abdullah R, et al. Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. J Pharmacol Exp Ther. 2012;342:770-9 pubmed publisher
    ..These results suggest that AEA and/or its prostamide metabolites in the renal medulla may represent medullipin and function as a regulator of body fluid and MAP...
  66. Sasser J, Moningka N, Tsarova T, Baylis C. Nebivolol does not protect against 5/6 ablation/infarction induced chronic kidney disease in rats - comparison with angiotensin II receptor blockade. Life Sci. 2012;91:54-63 pubmed publisher
    ..Here, we investigated whether Nebivolol attenuates hypertension and renal injury after 5/6 ablation/infarction (A/I). Efficacy was compared to the AT1 receptor antagonist Olmesartan...
  67. Verlander J, CHU D, Lee H, Handlogten M, Weiner I. Expression of glutamine synthetase in the mouse kidney: localization in multiple epithelial cell types and differential regulation by hypokalemia. Am J Physiol Renal Physiol. 2013;305:F701-13 pubmed publisher
    ..Glutamine synthetase is likely to mediate an important role in renal ammonia metabolism...
  68. López González Z, Ayala Aguilera C, Martinez Morales F, Galicia Cruz O, Salvador Hernández C, Pedraza Chaverri J, et al. Immunolocalization of hyperpolarization-activated cationic HCN1 and HCN3 channels in the rat nephron: regulation of HCN3 by potassium diets. Histochem Cell Biol. 2016;145:25-40 pubmed publisher
    ..Since HCN channels activate with membrane hyperpolarization, our results suggest that HCN channels may play a role in the Na(+)-K(+)-ATPase activity, contributing to Na(+), K(+), and acid-base homeostasis in the rat kidney. ..
  69. Nemmar A, Al Salam S, Zia S, Yasin J, Al Husseni I, Ali B. Diesel exhaust particles in the lung aggravate experimental acute renal failure. Toxicol Sci. 2010;113:267-77 pubmed publisher
    ..These included marked interstitial cell infiltration and congestion. We conclude that the presence of DEP in the lung aggravated the renal, pulmonary, and systemic effects of CP-induced ARF...
  70. Osorio H, Bautista R, Rios A, Franco M, Santamaría J, Escalante B. Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats. Diabetes Res Clin Pract. 2009;86:e46-9 pubmed publisher
    ..We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats...
  71. Tirapelli L, Barione D, Trazzi B, Tirapelli D, Novas P, Silva C, et al. Comparison of two models for evaluation histopathology of experimental renal ischemia. Transplant Proc. 2009;41:4083-7 pubmed publisher
    ..Evaluating tubular lesions after 2 periods of experimental ischemia with light microscopy allowed us to conclude that the Goujon classification better characterized the main changes in cortical renal tubules after ischemia...
  72. Lu Y, Yin L, Chang W, Huang J. Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats. J Biosci Bioeng. 2010;110:709-15 pubmed publisher
    ..The results obtained in this study indicate that L. reuteri GMNL-263 treatment may protect STZ-induced diabetic rats from hyperglycemia-enhanced renal fibrosis...
  73. Zhu Q, Xia M, Wang Z, Li P, Li N. A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. Am J Physiol Renal Physiol. 2011;301:F35-41 pubmed publisher
    ..It is concluded that S1P is a novel diuretic factor in the renal medulla and may be an important regulator of sodium homeostasis...
  74. Hwang H, Cho M, Ko C. The necessity of voiding cystourethrography in children with prenatally diagnosed hydronephrosis. J Int Med Res. 2011;39:603-8 pubmed
    ..Further information is needed to develop the optimal approach to the evaluation of prenatal hydronephrosis, with reliable parameters that avoid invasive procedures such as VCUG...
  75. Lane B, Chen H, Morrow M, Anema J, Kahnoski R. Increasing use of kidney sparing approaches for localized renal tumors in a community based health system: impact on renal functional outcomes. J Urol. 2011;186:1229-35 pubmed publisher
    ..The reasons and impact of this disparity are largely unknown. We examined the trend in kidney sparing approaches in a community based health care system to examine associated factors and impact on renal function...
  76. Xu P, Xu J, Li Z, Yang Z. Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS ONE. 2012;7:e38503 pubmed publisher
    ..From these in vivo experiments, we concluded that the expression of TRPC6 was active in the developing mouse kidney cortex, and followed a loss of expression with the development of kidney...
  77. Poon J, Josephy P. Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase. Xenobiotica. 2012;42:1178-86 pubmed publisher
    ..We purified porcine kidney cortex membrane dipeptidase (MDP) to homogeneity, via phosphatidylinositol-specific phospholipase C-mediated cleavage ..
  78. Qu W, Jiang Z, Zhang C, Zou J, Sun L, Shi Y, et al. Regulation of C-type natriuretic peptides and natriuretic peptide receptor-B expression in diabetic rats renal treated by Tongluo Recipe. Chin J Integr Med. 2013;19:524-31 pubmed publisher
    ..To investigate the expression of C-type natriuretic peptides (CNP) and natriuretic peptide receptor-B (NPR-B) receptor in diabetic rats renal cortex, and the regulation by Tongluo Recipe (TLR)...
  79. Xie L, Sparks M, Li W, Qi Y, Liu C, Coffman T, et al. Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. NMR Biomed. 2013;26:1853-63 pubmed publisher
    ..QSM was very sensitive in detecting pathology caused by small focal inflammation and fibrosis. QSM offers a new MR contrast mechanism to study this common disease marker in the kidney...
  80. Zhou G, Cheung A, Liu X, Huang Y. Valsartan slows the progression of diabetic nephropathy in db/db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation. Clin Sci (Lond). 2014;126:707-20 pubmed publisher
    ..Thus high doses of valsartan not only reduce albuminuria maximally, but also halt the progression of the glomerulosclerosis resulting from Type 2 diabetes via a reduction in podocyte injury and renal oxidative stress and inflammation. ..
  81. Sullivan J, Pardieck J, Hyndman K, Pollock J. Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2010;298:R61-9 pubmed publisher
    ..Our data suggest that the effect of the sex of the animal on NOS activity and expression is different in the three regions of the SHR kidney and supports the hypothesis that male SHR have lower NO bioavailability compared with females...
  82. Al Said J, Kamel O. Changes in renal cortical and medullary perfusion in a patient with renal vein thrombosis. Saudi J Kidney Dis Transpl. 2010;21:123-7 pubmed
    ..The blood flow to the kidney im-proved within four days after therapy with anticoagulation and pulse steroids. The sequences of events that take place need further studies for validation...
  83. Hanjangsit K, Dimitrov P, Karmaus W, Batuman V, Simeonov V, Bonev A, et al. Reduced kidney size in adult offspring of Balkan endemic nephropathy patients and controls: a prospective study. Am J Med Sci. 2010;340:94-102 pubmed publisher
    ..To investigate the clinical course of kidney sizes in the offspring of BEN and non-BEN parents, we followed up a cohort of adult offspring over 5 years. We hypothesized that parental history affects kidney dimensions...
  84. Wang L, Zhou X, Yang D, Wang Z. Effects of lead and/or cadmium on the distribution patterns of some essential trace elements in immature female rats. Hum Exp Toxicol. 2011;30:1914-23 pubmed publisher
    ..Moreover, there was an obvious synergistic effect of lead combined with cadmium on the distribution patterns of these essential trace elements, which may be related to the severity of co-exposure to these two metals...
  85. Jena S, Chainy G, Dandapat J. Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin. Mol Biol Rep. 2012;39:1193-203 pubmed publisher
    ..The over all results suggest that vitamin E and curcumin differentially modulate the altered antioxidant defence mechanism of rat kidney cortex under experimental hypothyroidism.
  86. VanderBrink B, Asanuma H, Hile K, Zhang H, Rink R, Meldrum K. Interleukin-18 stimulates a positive feedback loop during renal obstruction via interleukin-18 receptor. J Urol. 2011;186:1502-8 pubmed publisher
    ..We hypothesized that interleukin-18 stimulates a positive feedback loop during obstruction via interleukin-18 receptor to increase interleukin-18 gene expression and protein production...
  87. Villanueva S, Suazo C, Santapau D, Perez F, Quiroz M, Carreño J, et al. NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney. PLoS ONE. 2012;7:e39665 pubmed publisher
    ..These results demonstrate for the first time that NFAT5 is induced by hypoxia and could be a protective factor against ischemic damage...
  88. Hammadah M, Gaber L, Raghavan R. Renal cortical necrosis following a colonoscopy. Clin Nephrol. 2013;79:67-71 pubmed publisher
    ..PEG can be biodegraded to diethylene glycol (DEG), which is a nephrotoxic agent associated with RCN. Three months after presentation, the patient remains hemodialysis dependent...
  89. Grimm P, Taneja T, Liu J, Coleman R, Chen Y, Delpire E, et al. SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. J Biol Chem. 2012;287:37673-90 pubmed publisher
    ..As a result of the dependent nature of OSR1 on SPAK in the DCT, NCC is unable to be activated. Consequently, SPAK(-/-) mice are highly sensitive to dietary salt restriction, displaying prolonged negative sodium balance and hypotension. ..
  90. Gewin L, Vadivelu S, Neelisetty S, Srichai M, Paueksakon P, Pozzi A, et al. Deleting the TGF-? receptor attenuates acute proximal tubule injury. J Am Soc Nephrol. 2012;23:2001-11 pubmed publisher
    ..Taken together, these results suggest that TGF-? signaling in the proximal tubule has a detrimental effect on the response to AKI as a result of its proapoptotic effects. ..
  91. Robson P, Madhuranthakam A, Smith M, Sun M, Dai W, Rofsky N, et al. Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition. Acad Radiol. 2016;23:144-54 pubmed publisher
    ..3D ASL renal perfusion imaging provides isotropic-resolution images, with comparable quantitative perfusion values and image SNR in similar imaging time to single-slice 2D ASL. ..
  92. Lee D, Cho E, Kim J, Kim Y, Lee H, Yu J, et al. Optimization of Split-Bolus CT Urography: Effect of Differences in Allocation of Contrast Medium and Prolongation of Imaging Delay. AJR Am J Roentgenol. 2017;209:W10-W17 pubmed publisher
    ..The purpose of this study was to find the optimal allocation ratio of contrast medium (CM) in split-bolus CT urography (CTU) and to investigate the effect of increased imaging delays for synchronous nephrographic-excretory phase imaging...