seminiferous epithelium

Summary

Summary: The epithelium lining the seminiferous tubules composed of primary male germ cells (SPERMATOGONIA) and supporting SERTOLI CELLS. As SPERMATOGENESIS proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains SPERMATOCYTES and the more advanced germ cells.

Top Publications

  1. Welsh M, Wu W, Parvinen M, Gilmont R. Variation in expression of hsp27 messenger ribonucleic acid during the cycle of the seminiferous epithelium and co-localization of hsp27 and microfilaments in Sertoli cells of the rat. Biol Reprod. 1996;55:141-51 pubmed
    The purpose of these studies was to define expression of hsp27 mRNA during the cycle of the seminiferous epithelium and to determine the distribution of hsp27 protein in the rat testis...
  2. Wong E, Sun S, Li M, Lee W, Cheng C. 14-3-3 Protein regulates cell adhesion in the seminiferous epithelium of rat testes. Endocrinology. 2009;150:4713-23 pubmed publisher
    ..A loss of 14-3-3theta expression at the apical ES was detected in the seminiferous epithelium before spermiation...
  3. Johnston D, Wright W, DiCandeloro P, Wilson E, Kopf G, Jelinsky S. Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells. Proc Natl Acad Sci U S A. 2008;105:8315-20 pubmed publisher
    ..Mammalian spermatogenesis is a complex biological process that occurs within a highly organized tissue, the seminiferous epithelium. The coordinated maturation of spermatogonia, spermatocytes, and spermatids suggests the existence of ..
  4. Cheng C, Wong E, Yan H, Mruk D. Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: new insights and advances. Mol Cell Endocrinol. 2010;315:49-56 pubmed publisher
    ..Recent studies have shown that in the microenvironment of the seminiferous epithelium, wherein each Sertoli cell supports approximately 30-50 germ cells at different stages of development, ..
  5. Vendramini V, Sasso Cerri E, Miraglia S. Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status. Reprod Biol Endocrinol. 2010;8:3 pubmed publisher
    ..05. The rats killed 30 and 60 days after doxorubicin treatment showed diminution of seminiferous epithelium height and reduction on the frequency of tubular sections containing at least one type of differentiated ..
  6. Naito M, Hirai S, Terayama H, Qu N, Kuerban M, Musha M, et al. Postinflammation stage of autoimmune orchitis induced by immunization with syngeneic testicular germ cells alone in mice. Med Mol Morphol. 2012;45:35-44 pubmed publisher
    ..The results revealed that the lymphocytic infiltration finally resolved; however, the seminiferous epithelium persistently showed maturation arrest and the Sertoli cell-only feature...
  7. D Souza R, Gill Sharma M, Pathak S, Kedia N, Kumar R, Balasinor N. Effect of high intratesticular estrogen on the seminiferous epithelium in adult male rats. Mol Cell Endocrinol. 2005;241:41-8 pubmed
    ..To delineate the direct action of estrogen in the seminiferous epithelium, we studied the effects of high intratesticular estradiol...
  8. Xia W, Wong C, Lee N, Lee W, Cheng C. Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model. J Cell Physiol. 2005;205:141-57 pubmed
    ..extensive restructuring to permit germ cells to move across the blood-testis barrier (BTB) as well as the seminiferous epithelium from the basal compartment to the luminal edge to permit fully developed spermatids (spermatozoa) to be ..
  9. Freeman E, Jani P, Millette C. Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium. Cell Commun Adhes. 2002;9:189-204 pubmed
    ..Finally, inactivation of Sertoli cell Rho family proteins yields disruption of the actin cytoskeleton. ..

More Information

Publications73

  1. Morrow C, Tyagi G, Simon L, Carnes K, Murphy K, Cooke P, et al. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod. 2009;81:871-9 pubmed publisher
    ..In conclusion, CLDN5 is expressed in the seminiferous epithelium, appears to be regulated by multiple influences, and contributes to BTB function.
  2. Fleming S, Shank P, Boekelheide K. gamma-Tubulin overexpression in Sertoli cells in vivo: I. Localization to sites of spermatid head attachment and alterations in Sertoli cell microtubule distribution. Biol Reprod. 2003;69:310-21 pubmed
    ..of Sertoli cell microtubule networks, and overexpression of a gamma-tubulin-enhanced green fluorescent protein fusion protein was observed to localize to the site of elongate spermatid head attachment to the seminiferous epithelium.
  3. Hess R, Renato de Franca L. Spermatogenesis and cycle of the seminiferous epithelium. Adv Exp Med Biol. 2008;636:1-15 pubmed publisher
  4. Lui W, Lee W, Cheng C. Transforming growth factor beta3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Biol Reprod. 2003;68:1597-612 pubmed
    ..These results thus unequivocally demonstrate that TGFbeta3 utilizes the p38 MAP kinase pathway to regulate Sertoli cell TJ dynamics...
  5. Xiao X, Mruk D, Lee W, Cheng C. c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes. Int J Biochem Cell Biol. 2011;43:651-65 pubmed publisher
    ..known as the apical ectoplasmic specialization (apical ES, a testis-specific adherens junction) in the seminiferous epithelium. However, the mechanism(s) that regulates these critical events in the testis remains unknown...
  6. Balarini M, de Paula T, da Matta S, Peixoto J, Guião Leite F, Rossi Júnior J, et al. Stages and duration of the cycle of the seminiferous epithelium in oncilla (Leopardus tigrinus, Schreber, 1775). Theriogenology. 2012;77:873-80 pubmed publisher
    Six adult Leopardus tigrinus (oncilla) were studied to characterize stages of the seminiferous epithelium cycle and its relative frequency and duration, as well as morphometric parameters of the testes...
  7. Lee N, Mruk D, Conway A, Cheng C. Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis. J Androl. 2004;25:200-15 pubmed
    During spermatogenesis, the movement of germ cells across the seminiferous epithelium is associated with extensive junction restructuring. Yet the underlying mechanism (or mechanisms) that regulates these events is largely unknown...
  8. Lee N, Leung K, Wo J, Tam P, Yeung W, Luk J. Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium. Apoptosis. 2006;11:1215-29 pubmed
    ..ZO-1, the only known adaptor of connexins in the testis, was reduced and remained in a low level in the seminiferous epithelium. As such, the alterations of connexins in seminiferous epithelium may induce apoptotic signaling in the ..
  9. Morrow C, Mruk D, Cheng C, Hess R. Claudin and occludin expression and function in the seminiferous epithelium. Philos Trans R Soc Lond B Biol Sci. 2010;365:1679-96 pubmed publisher
    ..review will discuss the characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB.
  10. Li M, Xia W, Mruk D, Wang C, Yan H, Siu M, et al. Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes. J Endocrinol. 2006;190:313-29 pubmed
    ..migration of preleptotene and leptotene spermatocytes from the basal to the adluminal compartment in the seminiferous epithelium of adult rat testes, which occurs at late stage VII through early stage VIII of the epithelial cycle, is ..
  11. Okuma Y, O Connor A, Hayashi T, Loveland K, de Kretser D, Hedger M. Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat. J Endocrinol. 2006;190:331-40 pubmed
    Production and regulation of activin A and inhibin B during the cycle of the seminiferous epithelium were investigated in adult rats...
  12. Bartles J, Wierda A, Zheng L. Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. J Cell Sci. 1996;109 ( Pt 6):1229-39 pubmed
  13. Johnston D, Jelinsky S, Zhi Y, Finger J, Kopf G, Wright W. Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells. Ann N Y Acad Sci. 2007;1120:36-46 pubmed publisher
    ..tubules at stages I, II-III, IV-V, VI, VIIa,b, VIIc,d, VIII, IX- XI, XII, XIII-XIV of the cycle of the seminiferous epithelium using RAE 230_2.0 microarrays...
  14. Soares J, Avelar G, Franca L. The seminiferous epithelium cycle and its duration in different breeds of dog (Canis familiaris). J Anat. 2009;215:462-71 pubmed publisher
    ..The aim of the present study was to carry out a comparative investigation of the stages of the seminiferous epithelium cycle and its duration in different breeds of dog...
  15. Young J, Takai Y, Kojic K, Vogl A. Internalization of adhesion junction proteins and their association with recycling endosome marker proteins in rat seminiferous epithelium. Reproduction. 2012;143:347-57 pubmed publisher
    ..cytoskeleton-related structures that are formed in association with intercellular junctions in the seminiferous epithelium. They consist of a cylindrical double-membrane core composed of the plasma membranes of the two attached ..
  16. Lee N, Yeung W, Luk J. Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction. Front Biosci. 2007;12:1552-62 pubmed
    ..In the testis, at least eleven connexins are associated with the Sertoli and germ cells of the seminiferous epithelium and the Leydig cells of the interstitium, modulating spermatogenesis and steroidogenesis, respectively...
  17. Ranpura S, Deshmukh U, Reddi P. NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. J Androl. 2008;29:186-97 pubmed
    ..Based on these results, we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors...
  18. Beardsley A, Robertson D, O Donnell L. A complex containing alpha6beta1-integrin and phosphorylated focal adhesion kinase between Sertoli cells and elongated spermatids during spermatid release from the seminiferous epithelium. J Endocrinol. 2006;190:759-70 pubmed
    ..We conclude that spermatid release during spermiation is mediated by a 'disengagement complex' containing alpha(6)beta(1)-integrin and phospho-FAK, the function of which can be affected by gonadotrophin suppression...
  19. Wang C, Mruk D, Lee W, Cheng C. Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface. Exp Cell Res. 2007;313:1373-92 pubmed
    ..as an adhesion molecule in maintaining the inter-Sertoli cell junctions at the basal compartment of the seminiferous epithelium. In addition, CAR may confer adhesion between Sertoli and germ cells at the Sertoli-germ cell interface...
  20. Chauvin T, Griswold M. Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium. Biol Reprod. 2004;70:744-51 pubmed
    ..We postulate that this upregulation is a result of the capability of the Sertoli cell to sense and then react to a change in osmolarity by increasing the transport and production of the osmolyte myo-inositol...
  21. Widłak W, Benedyk K, Vydra N, Głowala M, Scieglinska D, Małusecka E, et al. Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium. Acta Biochim Pol. 2003;50:535-41 pubmed
    ..smaller than those of wild-type males and histological analysis showed massive degeneration of the seminiferous epithelium. The lumen of tubules was devoid of spermatids and spermatozoa and using the TUNEL method we demonstrated ..
  22. Lie P, Mruk D, Lee W, Cheng C. Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium. FASEB J. 2009;23:2555-67 pubmed publisher
    In the seminiferous epithelium, Eps8 is localized to actin-based cell junctions at the blood-testis barrier (BTB) and the apical ectoplasmic specialization (ES) in stage V-VI tubules but is considerably diminished in stage VIII tubules...
  23. Lee N, Cheng C. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. J Cell Physiol. 2005;202:344-60 pubmed
    ..Yet it is virtually unknown regarding the role of protein kinases in Sertoli-germ cell AJ dynamics in the seminiferous epithelium of the testis...
  24. Oakberg E. Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat. 1956;99:507-16 pubmed
  25. Sarkar O, Xia W, Mruk D. Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions. J Cell Physiol. 2006;208:175-87 pubmed
    ..In this study, we examine the role of soluble guanylate cyclase (sGC) in junction restructuring in the seminiferous epithelium of the rat testis...
  26. Wistuba J, Schrod A, Greve B, Hodges J, Aslam H, Weinbauer G, et al. Organization of seminiferous epithelium in primates: relationship to spermatogenic efficiency, phylogeny, and mating system. Biol Reprod. 2003;69:582-91 pubmed
    ..We speculate that the presence of a single-stage/multistage organization might simply reflect germ cell clonal size. Our findings further indicate that sperm competition in primates is not reflected at the level of testicular function...
  27. Batias C, Siffroi J, Fenichel P, Pointis G, Segretain D. Connexin43 gene expression and regulation in the rodent seminiferous epithelium. J Histochem Cytochem. 2000;48:793-805 pubmed
    ..and indirect immunofluorescence to study the distribution of Cx43 mRNA and protein in the rodent seminiferous epithelium. During mouse testis maturation, Cx43 mRNA and its corresponding protein were first detected in the ..
  28. Tanwar P, Zhang L, TEIXEIRA J. Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium. Mol Endocrinol. 2011;25:1725-39 pubmed publisher
  29. Beguelini M, Moreira P, Faria K, Marchesin S, Morielle Versute E. Morphological characterization of the testicular cells and seminiferous epithelium cycle in six species of Neotropical bats. J Morphol. 2009;270:943-53 pubmed publisher
    ..With the exception of Myotis nigricans, the seminiferous epithelium cycle of the other five species studied was similar to those of other mammals, showing gradual stages by ..
  30. Wong E, Mruk D, Cheng C. Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochim Biophys Acta. 2008;1778:692-708 pubmed
    ..epithelial cycle of spermatogenesis to facilitate the migration of developing germ cells across the seminiferous epithelium. Furthermore, recent findings have shown that ES also confers cell orientation and polarity in the ..
  31. O Hara L, Welsh M, Saunders P, Smith L. Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit. Endocrinology. 2011;152:718-29 pubmed publisher
    ..This efferent duct obstruction leads to fluid back-pressure and disruption of the seminiferous epithelium of the adult testis...
  32. Dias F, Chiarini Garcia H, Parreira G, Melo R. Mice spermatogonial stem cells transplantation induces macrophage migration into the seminiferous epithelium and lipid body formation: high-resolution light microscopy and ultrastructural studies. Microsc Microanal. 2011;17:1002-14 pubmed publisher
    ..We demonstrate that SSCs transplantation elicits a rapid and potent recruitment of macrophages into the seminiferous epithelium (SE)...
  33. Morris I, Bardin C, Musto N, Thau R, Gunsalus G. Evidence suggesting that germ cells influence the bidirectional secretion of androgen binding protein by the seminiferous epithelium demonstrated by selective impairment of spermatogenesis with busulphan. Int J Androl. 1987;10:691-700 pubmed
    ..were low up to 43 days post treatment when only the early germ cell types were depleted from the seminiferous epithelium and when the testicular and epididymal contents of ABP were normal...
  34. França L, Becker Silva S, Chiarini Garcia H. The length of the cycle of seminiferous epithelium in goats (Capra hircus). Tissue Cell. 1999;31:274-80 pubmed
    This is the first report in literature showing the length of the seminiferous epithelium cycle in goats. In the present study, the duration of spermatogenesis was estimated using intratesticular injections of tritiated thymidine...
  35. Pinart E, Sancho S, Briz M, Bonet S, Garcia N, Badia E. Ultrastructural study of the boar seminiferous epithelium: changes in cryptorchidism. J Morphol. 2000;244:190-202 pubmed
    ..Spermatocytes are round cells moving from the basal compartment of the seminiferous epithelium to the luminal compartment...
  36. Leal M, Franca L. The seminiferous epithelium cycle length in the black tufted-ear marmoset (Callithrix penicillata) is similar to humans. Biol Reprod. 2006;74:616-24 pubmed
  37. Xia W, Cheng C. TGF-beta3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study. Dev Biol. 2005;280:321-43 pubmed
    ..TJs and basal ectoplasmic specializations [ES, a testis-specific adherens junction (AJ) type] in the seminiferous epithelium of the rat testis, we sought to examine if TGF-beta3 would also regulate anchoring junction dynamics...
  38. Lui W, Lee W, Cheng C. TGF-betas: their role in testicular function and Sertoli cell tight junction dynamics. Int J Androl. 2003;26:147-60 pubmed
    ..This review summarizes recent advances of studies on TGF-betas in the testis, highlighting their regulatory role in TJ dynamics...
  39. Guttman J, Takai Y, Vogl A. Evidence that tubulobulbar complexes in the seminiferous epithelium are involved with internalization of adhesion junctions. Biol Reprod. 2004;71:548-59 pubmed
    ..Our results are consistent with the conclusion that tubulobulbar complexes are involved with the disassembly of ectoplasmic specializations and with the internalization of intercellular membrane adhesion domains during sperm release...
  40. Stumpp T, Freymuller E, Miraglia S. Sertoli cell function in albino rats treated with etoposide during prepubertal phase. Histochem Cell Biol. 2006;126:353-61 pubmed
    ..on Sertoli cells analyzing the function of this cell and relating it with the integrity and damage of the seminiferous epithelium. Prepubertal albino rats received 5 mg/kg of etoposide for eight consecutive days and were sacrificed in ..
  41. Steger K, Aleithe I, Behre H, Bergmann M. The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. Mol Hum Reprod. 1998;4:227-33 pubmed
    ..In normal seminiferous epithelium Ki-67 is expressed in nuclei of spermatogonia, while PCNA additionally occurs in nuclei of primary ..
  42. Lie P, Cheng C, Mruk D. The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol. 2011;286:223-69 pubmed publisher
    ..Mammalian spermatogenesis, a complex process that involves the movement of developing germ cells across the seminiferous epithelium, entails extensive restructuring of Sertoli-Sertoli and Sertoli-germ cell junctions...
  43. Correa L, Miller M. Microtubule depolymerization in rat seminiferous epithelium is associated with diminished tyrosination of alpha-tubulin. Biol Reprod. 2001;64:1644-52 pubmed
    ..Similar effects were seen with colchicine, although loss of total tubulin protein was measured. Thus, decreased tyrosination of the microtubule pool of tubulin appears to be associated with depolymerization of microtubules...
  44. Beltrame F, Caneguim B, Miraglia S, Cerri P, Sasso Cerri E. Vitamin B12 supplement exerts a beneficial effect on the seminiferous epithelium of cimetidine-treated rats. Cells Tissues Organs. 2011;193:184-94 pubmed publisher
    ..However, vitamin B(12) supplement is able to stimulate spermatogenesis and restore the number of Sertoli cells, softening the harmful effect of cimetidine on spermatogenesis...
  45. Pinart E, Bonet S, Briz M, Pastor L, Sancho S, Garcia N, et al. Morphological and histochemical characteristics of the lamina propria in scrotal and abdominal testes from postpubertal boars: correlation with the appearance of the seminiferous epithelium. J Anat. 2001;199:435-48 pubmed
    ..The basal lamina formed infoldings toward the seminiferous epithelium and contained small cells. Both inner and outer peritubular cells were fibroblasts of immature appearance...
  46. Wang Y, Zhao H, Sheng X, Gambino P, Costello B, Bojanowski K. Protective effect of Fructus Lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82:169-75 pubmed
    ..Fructus Lycii polysaccharides (FLPS) inhibit time- and hyperthermia-induced structural damage in murine seminiferous epithelium, in vitro...
  47. Lee N, Cheng C. Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development?. Hum Reprod Update. 2004;10:349-69 pubmed
    ..Each tubule is morphologically divided into (i) the seminiferous epithelium composing Sertoli and germ cells, and (ii) the basement membrane (a modified form of extracellular matrix)..
  48. Mruk D, Cheng C. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev. 2004;25:747-806 pubmed
    ..Other factors such as proteases, protease inhibitors, GTPases, kinases, and phosphatases also come into play. In this review, we focus on this cellular phenomenon, recapping recent developments in the field...
  49. Wong C, Xia W, Lee N, Mruk D, Lee W, Cheng C. Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes. Endocrinology. 2005;146:1192-204 pubmed
    ..adherens junction type restricted to the Sertoli-round/elongating/elongate spermatid interface in the seminiferous epithelium. An endogenous testosterone (T) suppression model was used to study the regulation of apical ES dynamics ..
  50. Young J, Guttman J, Vaid K, Vogl A. Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Biol Reprod. 2009;80:162-74 pubmed publisher
    ..projections that resemble podosomes in other systems and form at intercellular junctions in the seminiferous epithelium of the mammalian testis...
  51. Sá R, Neves R, Fernandes S, Alves C, Carvalho F, Silva J, et al. Cytological and expression studies and quantitative analysis of the temporal and stage-specific effects of follicle-stimulating hormone and testosterone during cocultures of the normal human seminiferous epithelium. Biol Reprod. 2008;79:962-75 pubmed publisher
    In vitro culturing of normal human seminiferous epithelium remains largely unexplored...
  52. Baines H, Nwagwu M, Furneaux E, Stewart J, Kerr J, Mayhew T, et al. Estrogenic induction of spermatogenesis in the hypogonadal (hpg) mouse: role of androgens. Reproduction. 2005;130:643-54 pubmed
    ..markedly attenuated both the estradiol-induced increase in testicular weight and the proliferation of the seminiferous epithelium, as revealed by morphometric analysis...
  53. Myers M, Ebling F, Nwagwu M, Boulton R, Wadhwa K, Stewart J, et al. Atypical development of Sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse. J Anat. 2005;207:797-811 pubmed
    ..We conclude that in hpg mice, chronic gonadotrophin insufficiency restrains Sertoli cell proliferation and maturation, forming pseudo-adult-type Sertoli cells that are incapable of supporting germ cell proliferation and maturation...
  54. Wang C, Cheng C. A seamless trespass: germ cell migration across the seminiferous epithelium during spermatogenesis. J Cell Biol. 2007;178:549-56 pubmed
    During spermatogenesis, preleptotene spermatocytes traverse the blood-testis barrier (BTB) in the seminiferous epithelium, which is reminiscent of viral pathogens breaking through the tight junctions of host epithelial cells...
  55. Horn M, Ramos A, Winkelmann L, Matte U, Goldani H, Silveira T. Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis. Int Braz J Urol. 2006;32:94-9; discussion 99 pubmed
    Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4).
  56. Hess R. Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol Reprod. 1990;43:525-42 pubmed
    The stages of the cycle in the rat seminiferous epithelium are illustrated for testes fixed by vascular perfusion and embedded in plastic resins...
  57. O Bryan M, Grima J, Mruk D, Cheng C. Haptoglobin is a Sertoli cell product in the rat seminiferous epithelium: its purification and regulation. J Androl. 1997;18:637-45 pubmed
  58. Yan H, Mruk D, Lee W, Cheng C. Ectoplasmic specialization: a friend or a foe of spermatogenesis?. Bioessays. 2007;29:36-48 pubmed
    ..junction type, this hybrid nature of ES facilitates the extensive junction-restructuring events in the seminiferous epithelium during spermatogenesis...
  59. Cheng C, Wong E, Lie P, Mruk D, Xiao X, Li M, et al. Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis. Histol Histopathol. 2011;26:1465-74 pubmed publisher
    In mammalian testis, spermatogenesis takes place in the seminiferous epithelium of the seminiferous tubule, which is composed of a series of cellular events...
  60. Upadhyay R, D Souza R, Sonawane S, Gaonkar R, Pathak S, Jhadav A, et al. Altered phosphorylation and distribution status of vimentin in rat seminiferous epithelium following 17?-estradiol treatment. Histochem Cell Biol. 2011;136:543-55 pubmed publisher
    ..In the rat, during stages I-V and XI-XIV of the seminiferous epithelium, vimentin is localized in the perinuclear area with filaments projecting into the apical region toward ..
  61. Ebling F, Brooks A, Cronin A, Ford H, Kerr J. Estrogenic induction of spermatogenesis in the hypogonadal mouse. Endocrinology. 2000;141:2861-9 pubmed
    ..increase in total seminiferous tubule volume and a 4- to 5-fold increase in the total volume of the seminiferous epithelium. In all experiments, spermatogenesis proceeded in the absence of measurable androgen concentrations, but ..
  62. Zou Y, Millette C, Sperry A. KRP3A and KRP3B: candidate motors in spermatid maturation in the seminiferous epithelium. Biol Reprod. 2002;66:843-55 pubmed
    ..Our findings suggest a possible role for KRP3 motor isoforms in spermatid maturation mediated by possible interaction with the Ran GTPase...
  63. Gilleron J, Carette D, Durand P, Pointis G, Segretain D. Connexin 43 a potential regulator of cell proliferation and apoptosis within the seminiferous epithelium. Int J Biochem Cell Biol. 2009;41:1381-90 pubmed publisher
  64. Cheng C, Mruk D. An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective. Crit Rev Biochem Mol Biol. 2009;44:245-63 pubmed publisher
    ..e. spermatozoa) at the luminal edge of the seminiferous epithelium undergo "spermiation" at stage VIII of the seminiferous epithelial cycle...