Summary: Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

Top Publications

  1. Longepied G, Saut N, Aknin Seifer I, Levy R, Frances A, Metzler Guillemain C, et al. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010;25:2655-63 pubmed publisher
    ..Immunocytochemical analysis of spermatocytes with an antibody against a synaptonemal complex component indicates synapsis to be largely unaffected in 13-..
  2. Kojima K, Kuramochi Miyagawa S, Chuma S, Tanaka T, Nakatsuji N, Kimura T, et al. Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells. Genes Cells. 2009;14:1155-65 pubmed publisher
    ..These data suggest that the formation of complexes between MILI, MIWI and TDRD1/MTR-1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis. ..
  3. Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, et al. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol. 2012;198:165-72 pubmed publisher
    ..Based on subcellular localization screening in mouse spermatocytes, we identified a novel germ cell-specific protein, KASH5, that localized exclusively at telomeres from the ..
  4. Redhouse J, Mozziconacci J, White R. Co-transcriptional architecture in a Y loop in Drosophila melanogaster. Chromosoma. 2011;120:399-407 pubmed publisher
    The Y loops of Drosophila spermatocytes are formed by the expression of huge individual transcription units on the Y chromosome and their large size provides a unique system for the investigation of the organisation of transcription in ..
  5. Bao J, Wu Q, Song R, Jie Z, Zheng H, Xu C, et al. RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids. Mol Cell Endocrinol. 2011;333:134-42 pubmed publisher
    ..In primary spermatocytes RANBP17 was mainly localized to the XY body...
  6. An J, Kim E, Zakrzewska A, Yoo Y, Jang J, Han D, et al. UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells. PLoS ONE. 2012;7:e37414 pubmed publisher
    ..of cytosolic proteins, the major phenotype of UBR2-deficient male mice is infertility caused by arrest of spermatocytes at meiotic prophase I...
  7. Horn T, Schulz S, Maurer T, Gschwend J, Kübler H. Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. Med Oncol. 2011;28 Suppl 1:S423-5 pubmed publisher
    ..A review of the literature showed that all the three described patients developing metastatic disease did not receive adjuvant radiation therapy after orchiectomy, which might be considered in high-risk cases...
  8. Bellani M, Boateng K, McLeod D, Camerini Otero R. The expression profile of the major mouse SPO11 isoforms indicates that SPO11beta introduces double strand breaks and suggests that SPO11alpha has an additional role in prophase in both spermatocytes and oocytes. Mol Cell Biol. 2010;30:4391-403 pubmed publisher
    ..Protein quantification in juvenile mice and in prophase mutants indicates that early spermatocytes synthesize primarily SPO11beta...
  9. Dray E, Dunlop M, Kauppi L, San Filippo J, Wiese C, Tsai M, et al. Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Proc Natl Acad Sci U S A. 2011;108:3560-5 pubmed publisher
    ..we show that RAD51AP1 is expressed in mouse testes, and that RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination.

More Information


  1. Grad I, Cederroth C, Walicki J, Grey C, Barluenga S, Winssinger N, et al. The molecular chaperone Hsp90? is required for meiotic progression of spermatocytes beyond pachytene in the mouse. PLoS ONE. 2010;5:e15770 pubmed publisher
    ..Over time, the number of spermatocytes and the levels of the meiotic regulators and Hsp90 interactors Hsp70-2, NASP and Cdc2 are reduced...
  2. Fukuda T, Daniel K, Wojtasz L, Toth A, Hoog C. A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes. Exp Cell Res. 2010;316:158-71 pubmed publisher
    ..Our results therefore strongly suggest that also mammalian cells use a HORMA domain-containing protein as part of a surveillance system that monitors synapsis or other interactions between homologs...
  3. Chimento A, Sirianni R, Delalande C, Silandre D, Bois C, Ando S, et al. 17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha. Mol Cell Endocrinol. 2010;320:136-44 pubmed publisher
    ..estrogens were able to directly activate rapid signaling pathways controlling spermatogenesis in rat pachytene spermatocytes (PS). Classically, estrogens act by binding to estrogen receptors (ERs) alpha and beta...
  4. Holloway J, Mohan S, Balmus G, Sun X, Modzelewski A, Borst P, et al. Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genet. 2011;7:e1002094 pubmed publisher
    ..BTBD12 localizes to pre-meiotic spermatogonia and to meiotic spermatocytes in wildtype males. Btbd12 mutant mice have less than 15% normal spermatozoa and are subfertile...
  5. Zheng K, Xiol J, Reuter M, Eckardt S, Leu N, McLaughlin K, et al. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010;107:11841-6 pubmed publisher
    ..The Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mouse mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins...
  6. Kogo H, Kowa Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, et al. Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. J Hum Genet. 2010;55:293-9 pubmed publisher
    ..Cell fractions enriched in spermatogonia, leptotene/zygotene spermatocytes or pachytene spermatocytes from developing mouse testis were separately isolated by density gradient ..
  7. Holloway J, Morelli M, Borst P, Cohen P. Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination. J Cell Biol. 2010;188:779-89 pubmed publisher
  8. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, et al. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009;17:775-87 pubmed publisher
  9. Moon S, Cho B, Min S, Lee D, Chung Y. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Development. 2011;138:3835-45 pubmed publisher
    ..Flies lacking THOC5 showed a meiotic arrest phenotype with severe nucleolar disruption in primary spermatocytes. A functional GFP-tagged fusion protein, THOC5-GFP, revealed a unique pattern of THOC5 localization near the ..
  10. Li W, Wu Z, Zhao J, Guo S, Li Z, Feng X, et al. Transient protection from heat-stress induced apoptotic stimulation by metastasis-associated protein 1 in pachytene spermatocytes. PLoS ONE. 2011;6:e26013 pubmed publisher
    ..To further dissect the underlying mechanism, we addressed here the fine coordination between MTA1 and p53 in pachytene spermatocytes upon hyperthermal stimulation.
  11. Fritsche M, Reinholdt L, Lessard M, Handel M, Bewersdorf J, Heermann D. The impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus. PLoS ONE. 2012;7:e36282 pubmed publisher
    ..This suggests that while effects of entropy impact SC organization, the dedicated action of proteins or actin cables is required to fine-tune the spatial ordering of SCs within the cell nucleus. ..
  12. Brower J, Lim C, Jorgensen M, Oh S, Terada N. Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells. Reproduction. 2009;138:463-70 pubmed publisher
    ..During meiosis I, there is a dramatic increase in the number of mitochondria present within the developing spermatocytes, suggesting an increased necessity for ATP production and utilization...
  13. Giansanti M, Fuller M. What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis. Cytoskeleton (Hoboken). 2012;69:869-81 pubmed publisher
    ..may be performed on them, and the availability of numerous mutants and other genetic tools, Drosophila spermatocytes have provided an excellent system for exploring the mechanistic basis for the temporally programmed and ..
  14. Fu J, Glover D. Structured illumination of the interface between centriole and peri-centriolar material. Open Biol. 2012;2:120104 pubmed publisher
    ..By contrast, the centrioles of spermatocytes elongate from a pre-existing proximal unit during the G2 preceding meiosis...
  15. Egorova K, Olenkina O, Kibanov M, Kalmykova A, Gvozdev V, Olenina L. Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark. J Mol Biol. 2009;389:895-906 pubmed publisher
    ..We also observed that Stellate underwent lysine methylation and mimicked trimethyl-H3K9 epigenetic modification of histone H3 tail...
  16. Paronetto M, Messina V, Barchi M, Geremia R, Richard S, Sette C. Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells. Nucleic Acids Res. 2011;39:4961-74 pubmed publisher
    ..report an interaction between Sam68 and the phosphorylated forms of the RNA polymerase II (RNAPII) in meiotic spermatocytes. RNase treatment decreased but did not abolish the interaction, consistently with in vitro binding of RNAPII ..
  17. Lange J, Pan J, Cole F, Thelen M, Jasin M, Keeney S. ATM controls meiotic double-strand-break formation. Nature. 2011;479:237-40 pubmed publisher
    ..of SPO11-oligonucleotide complexes, by-products of meiotic DSB formation, are elevated at least tenfold in spermatocytes lacking ATM...
  18. Vasco C, Manterola M, Page J, Zuccotti M, de la Fuente R, Redi C, et al. The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice. Chromosome Res. 2012;20:269-78 pubmed publisher
    ..the frequency of unsynapsed chromosomes and of those positive to ?H2AX (a marker of MSUC) labelling in spermatocytes of 3-, 5- and 7-month-old Rb heterozygotes...
  19. Montembault E, Zhang W, Przewloka M, Archambault V, Sevin E, Laue E, et al. Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. J Cell Biol. 2010;191:1351-65 pubmed publisher
    ..Our findings indicate that Nesd is a novel carbohydrate-binding protein that functions together with centralspindlin in late cytokinesis, thus highlighting the importance of glycosylation in this process...
  20. Lu L, Xiong Y, Kuang H, Korakavi G, Yu X. Regulation of the DNA damage response on male meiotic sex chromosomes. Nat Commun. 2013;4:2105 pubmed publisher
    ..This analysis shows that there are important differences between the regulation of the DNA damage response at the XY body and at DNA damage sites in somatic cells. ..
  21. Frost R, Hamra F, Richardson J, Qi X, Bassel Duby R, Olson E. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010;107:11847-52 pubmed publisher
    ..expressed in germ cells with increasing expression from gonocytes/type A spermatogonia to pachytene spermatocytes. Primary spermatocytes of Mov10l1(-/-) mice show activation of LTR and LINE-1 retrotransposons, followed by ..
  22. Alekseev O, Richardson R, O Rand M. Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse. Biol Reprod. 2009;81:739-48 pubmed publisher
    In mammalian spermatocytes, cell division cycle protein 2 (CDC2)/cyclin B1 and the chaperone heat shock protein A2 (HSPA2) are required for the G2-->M transition in prophase I...
  23. An J, Kim E, Jiang Y, Zakrzewska A, Kim D, Lee M, et al. UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A. 2010;107:1912-7 pubmed publisher
    ..spatiotemporally mark meiotic chromatin regions subject to transcriptional silencing, and UBR2-deficient spermatocytes fail to induce the ubiquitination of H2A during meiosis...
  24. Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes. Microsc Res Tech. 2010;73:241-78 pubmed publisher
    ..three specific functional phases: proliferation, meiosis, and differentiation, and it involves spermatogonia, spermatocytes, and spermatids...
  25. Ishiguro K, Kim J, Shibuya H, Hern ndez Hern ndez A, Suzuki A, Fukagawa T, et al. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 2014;28:594-607 pubmed publisher
    ..Intriguingly, the ability to recognize homologs is retained in Sun1 knockout spermatocytes, in which telomere-directed chromosome movement is abolished, and this is the case even in Spo11 knockout ..
  26. Brennan L, Haukedal J, Earle J, Keddie B, Harris H. Disruption of redox homeostasis leads to oxidative DNA damage in spermatocytes of Wolbachia-infected Drosophila simulans. Insect Mol Biol. 2012;21:510-20 pubmed publisher
    ..simulans is associated with an increase in DNA strand breaks in meiotic spermatocytes. Feeding exogenous antioxidants to male and female D...
  27. La Salle S, Sun F, Handel M. Isolation and short-term culture of mouse spermatocytes for analysis of meiosis. Methods Mol Biol. 2009;558:279-97 pubmed publisher
    ..Here we describe a method for preparing highly enriched pachytene spermatocytes from mouse testicular cell suspensions using cell-size fractionation by sedimentation through a bovine serum ..
  28. Qiao H, Chen J, Reynolds A, Hoog C, PADDY M, Hunter N. Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis. PLoS Genet. 2012;8:e1002790 pubmed publisher
    ..Here, we examine the interplay between SCs, recombination, and centromeres in a mammal. In mouse spermatocytes, centromeres do not serve as SC initiation sites and are invariably the last regions to synapse...
  29. Bisig C, Guiraldelli M, Kouznetsova A, Scherthan H, Hoog C, Dawson D, et al. Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. PLoS Genet. 2012;8:e1002701 pubmed publisher
    ..that telomeres associate in non-homologous pairs or small groups in B type spermatogonia and pre-leptotene spermatocytes, and this association is disrupted by deletion of the synaptonemal complex component SYCP3...
  30. Ko E, Martin R. Immunofluorescence analysis of human spermatocytes. Methods Mol Biol. 2009;558:401-18 pubmed publisher
    ..This has greatly stimulated research in human meiosis, leading to many exciting studies on the mechanisms underlying recombination and the generation of chromosome abnormalities...
  31. Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, et al. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol. 2012;14:424-30 pubmed publisher
    ..We show here that mammals exhibit progressive homeostatic control of recombination. In wild-type mouse spermatocytes, focus numbers for early recombination proteins (RAD51, DMC1) were highly variable from cell to cell, whereas ..
  32. Wu S, Hu Y, Liu H, Shi Y. Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis. Mol Cell Biol. 2009;29:6245-56 pubmed publisher
    ..In the YY1-deficient spermatocytes, we find a significant decrease in the global level of the heterochromatin markers (H3K9me3 and HP1-gamma) and ..
  33. LaFountain J, Cohan C, Oldenbourg R. Functional states of kinetochores revealed by laser microsurgery and fluorescent speckle microscopy. Mol Biol Cell. 2011;22:4801-8 pubmed publisher
    ..laser microsurgery to detach kinetochores with associated chromatin (K fragment) from meiotic chromosomes in spermatocytes from the crane fly Nephrotoma suturalis...
  34. Polevoy G, Wei H, Wong R, Szentpetery Z, Kim Y, Goldbach P, et al. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol. 2009;187:847-58 pubmed publisher
    ..III beta four wheel drive (Fwd) as a key regulator of Rab11 during cytokinesis in Drosophila melanogaster spermatocytes. We show Fwd is required for synthesis of PI 4-phosphate (PI4P) on Golgi membranes and for formation of PI4P-..
  35. Paul C, Nagano M, Robaire B. Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat. Biol Reprod. 2011;85:1269-78 pubmed publisher
    ..To test this hypothesis, pachytene spermatocytes and round spermatids were isolated from Brown Norway (BN) rats at 4 (young) and 18 (aged) mo of age...
  36. Cai X, Li J, Yang Q, Shi Q. Gamma-irradiation increased meiotic crossovers in mouse spermatocytes. Mutagenesis. 2011;26:721-7 pubmed publisher
    ..To examine the effects of ?-irradiation on meiotic crossovers in mouse spermatocytes, male mice were subjected to whole-body ?-irradiation at different sub-stages of meiotic prophase and ..
  37. Vernet N, Mahadevaiah S, Ojarikre O, Longepied G, Prosser H, Bradley A, et al. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011;21:787-93 pubmed publisher
    ..Apoptotic elimination of MI spermatocytes is seen in response to the univalent X chromosome of XSxr(a)O male mice [2], in which the X chromosome carries ..
  38. Stevens N, Roque H, Raff J. DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement. Dev Cell. 2010;19:913-9 pubmed publisher
    ..We conclude that DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and that they promote both centriole duplication and centriole cohesion in a Sak/Plk4-dependent manner...
  39. Forer A, Pickett Heaps J. Precocious (pre-anaphase) cleavage furrows in Mesostoma spermatocytes. Eur J Cell Biol. 2010;89:607-18 pubmed publisher
    ..Cleavage furrows are initiated during prometaphase in spermatocytes of the flatworm Mesostoma, becoming detectable soon after the spindles achieve bipolarity...
  40. O Shaughnessy P, Verhoeven G, De Gendt K, Monteiro A, Abel M. Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology. 2010;151:2343-8 pubmed publisher
    ..Both T and DHT increased numbers of spermatogonia and spermatocytes in hpg mice, but DHT has no effect on germ cell numbers in hpg.SCARKO and hpg.ARKO mice...
  41. Saferali A, Berlivet S, Schimenti J, Bartolomei M, Taketo T, Naumova A. Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm Genome. 2010;21:377-87 pubmed publisher
    ..In translocation carriers, DNMT3A was less abundant in a proportion of pachytene spermatocytes that also had unsynapsed pericentromeric regions of chromosomes 8 and 12...
  42. Wang J, Saxe J, Tanaka T, Chuma S, Lin H. Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Curr Biol. 2009;19:640-4 pubmed publisher
    ..Our results suggest that Mili interacts with Tdrd1 in the nuage and chromatoid body. This interaction does not contribute to piRNA biogenesis but represents a regulatory mechanism that is critical for spermatogenesis...
  43. Esakky P, Hansen D, Drury A, Moley K. Cigarette smoke condensate induces aryl hydrocarbon receptor-dependent changes in gene expression in spermatocytes. Reprod Toxicol. 2012;34:665-76 pubmed publisher
    ..To identify mechanisms by which this occurs, we evaluated expression of antioxidant genes in mouse spermatocytes in response to cigarette smoke condensate (CSC)...
  44. Roque H, Wainman A, Richens J, Kozyrska K, Franz A, Raff J. Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. J Cell Sci. 2012;125:5881-6 pubmed publisher
    ..Thus, in flies, Cep135/Bld10 is not essential for cartwheel assembly or for establishing the ninefold symmetry of centrioles; rather, it appears to stabilize the connection between inner and outer centriole components. ..
  45. Nordstrand L, Furu K, Paulsen J, Rognes T, Klungland A. Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nucleic Acids Res. 2012;40:10950-63 pubmed publisher
    ..Here, we confirm that most piRNAs in meiotic spermatocytes originate from clusters in non-repeat intergenic regions of DNA...
  46. Jordan P, Karppinen J, Handel M. Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci. 2012;125:5061-72 pubmed publisher
    ..Here we assess roles of polo-like kinases (PLKs) in mouse spermatocytes, both in vivo and during prophase exit induced ex vivo by the phosphatase inhibitor okadaic acid...
  47. Imai H, Hakkaku N, Iwamoto R, Suzuki J, Suzuki T, Tajima Y, et al. Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem. 2009;284:32522-32 pubmed publisher
    ..Umeda, M., and Nakagawa, Y. (2001) Biol. Reprod. 64, 674-683). To clarify whether defective GPx4 in spermatocytes causes male infertility, we established spermatocyte-specific GPx4 knock-out mice using a Cre-loxP system...
  48. Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H. HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells. 2012;17:439-54 pubmed publisher
    ..Our present results provide clues to HORMAD1-dependent checkpoint in response to asynapsis in mammalian meiosis...
  49. Ray D, Hogarth C, Evans E, An W, Griswold M, Ye P. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Biol Reprod. 2012;86:102 pubmed publisher
    ..We found ANKRD17 expression was predominantly restricted to pachytene spermatocytes and round spermatids...
  50. Gan H, Lin X, Zhang Z, Zhang W, Liao S, Wang L, et al. piRNA profiling during specific stages of mouse spermatogenesis. RNA. 2011;17:1191-203 pubmed publisher
    ..In this study, we first profiled the expression of small RNAs in type A spermatogonia, pachytene spermatocytes, and round spermatids by deep sequencing...
  51. Schramm S, Fraune J, Naumann R, Hernández Hernández A, Hoog C, Cooke H, et al. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. PLoS Genet. 2011;7:e1002088 pubmed publisher
    ..We conclude that SYCE3 enables chromosome loading of the other CE-specific proteins, which in turn would promote synapsis between homologous chromosomes...
  52. Inselman A, Nakamura N, Brown P, Willis W, Goulding E, Eddy E. Heat shock protein 2 promoter drives Cre expression in spermatocytes of transgenic mice. Genesis. 2010;48:114-20 pubmed publisher
    ..cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene also was detected at restricted sites in the brain, as occurs for endogenous ..
  53. Bustamante Marín X, Quiroga C, Lavandero S, Reyes J, Moreno R. Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes. Apoptosis. 2012;17:539-50 pubmed publisher
    ..Furthermore, autophagy has not been reported in spermatogenesis. Spermatocytes (meiotic cells) and spermatids (haploid cells) use lactate rather than glucose as their primary substrate for ..
  54. McCabe M, Tarulli G, Meachem S, Robertson D, Smooker P, Stanton P. Gonadotropins regulate rat testicular tight junctions in vivo. Endocrinology. 2010;151:2911-22 pubmed publisher
    ..It is concluded that gonadotropins maintain Sertoli cell TJs in the adult rat via a mechanism that includes the localization of occludin and claudin-11 at functional TJs...
  55. Sun F, Palmer K, Handel M. Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes. Development. 2010;137:1699-707 pubmed publisher
    ..repro8 causes male-limited infertility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition...
  56. Ahmed E, Philippens M, Kal H, de Rooij D, de Boer P. Genetic probing of homologous recombination and non-homologous end joining during meiotic prophase in irradiated mouse spermatocytes. Mutat Res. 2010;688:12-8 pubmed publisher
    ..Early and late pachytene and early diplotene spermatocytes that had completed crossing over were sampled...
  57. Delgehyr N, Rangone H, Fu J, Mao G, Tom B, Riparbelli M, et al. Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length. Curr Biol. 2012;22:502-9 pubmed publisher
  58. Riparbelli M, Callaini G, Megraw T. Assembly and persistence of primary cilia in dividing Drosophila spermatocytes. Dev Cell. 2012;23:425-32 pubmed publisher
    ..to this view, we show here that cilia assemble and persist through two meiotic divisions in Drosophila spermatocytes. Remarkably, all four centrioles assemble primary cilia-centriole complexes that transit from the plasma ..
  59. Mulugeta Achame E, Wassenaar E, Hoogerbrugge J, Sleddens Linkels E, Ooms M, Sun Z, et al. The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids. BMC Genomics. 2010;11:367 pubmed publisher
    ..We studied the relationship between these chromatin modifications and their effects on global gene expression patterns, in spermatocytes and spermatids.
  60. Kouznetsova A, Benavente R, Pastink A, Hoog C. Meiosis in mice without a synaptonemal complex. PLoS ONE. 2011;6:e28255 pubmed publisher
    ..While transmission electron microscopy failed to identify any remnants of the SC in SC-null spermatocytes, neither formation of the cohesion axes nor attachment of the chromosomes to the nuclear membrane was ..
  61. Papagiannouli F, Mechler B. discs large regulates somatic cyst cell survival and expansion in Drosophila testis. Cell Res. 2009;19:1139-49 pubmed publisher
    ..Our data demonstrate that dlg is essentially required in SCCs for their survival, expansion, and differentiation, and for the encapsulation of the germline cells...
  62. Qiao H, Prasada Rao H, Yang Y, Fong J, Cloutier J, Deacon D, et al. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014;46:194-9 pubmed publisher
    ..We suggest that SUMO and ubiquitin have antagonistic roles during meiotic recombination that are balanced to effect differential stabilization of recombination factors at crossover and non-crossover sites. ..
  63. Insco M, Leon A, Tam C, McKearin D, Fuller M. Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proc Natl Acad Sci U S A. 2009;106:22311-6 pubmed publisher