sperm tail

Summary

Summary: The posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility.

Top Publications

  1. Lhuillier P, Rode B, Escalier D, Lores P, Dirami T, Bienvenu T, et al. Absence of annulus in human asthenozoospermia: case report. Hum Reprod. 2009;24:1296-303 pubmed publisher
    ..The case we studied, so far unreported in human, confirms the involvement of Tat1 and Septin proteins in the constitution of the annulus, but also raises questions about the function of this structure in human sperm motility. ..
  2. Steels J, Estey M, Froese C, Reynaud D, Pace Asciak C, Trimble W. Sept12 is a component of the mammalian sperm tail annulus. Cell Motil Cytoskeleton. 2007;64:794-807 pubmed
    ..This study suggests Sept12 may be involved in mammalian fertility. ..
  3. Ho H, Suarez S. Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility. Biol Reprod. 2003;68:1590-6 pubmed
    ..We concluded that the intracellular Ca2+ store is the part of RNE that contains enlarged cisternae and that Ca2+ is released directly to the axoneme to trigger hyperactivated motility without the active participation of mitochondria. ..
  4. Cao W, Ijiri T, Huang A, Gerton G. Characterization of a novel tektin member, TEKT5, in mouse sperm. J Androl. 2011;32:55-69 pubmed publisher
    ..Immunofluorescence confirmed that TEKT5 was localized throughout the sperm tail in flagellar accessory structures...
  5. Stoltz J, Neff B. Sperm competition in a fish with external fertilization: the contribution of sperm number, speed and length. J Evol Biol. 2006;19:1873-81 pubmed
    ..58 times as many sperm as parentals to obtain equal paternity. Thus, the increased competitiveness of sneakers' sperm must come from a component of sperm quality other than speed or length. ..
  6. Zhang Y, Ou Y, Cheng M, Saadi H, Thundathil J, van der Hoorn F. KLC3 is involved in sperm tail midpiece formation and sperm function. Dev Biol. 2012;366:101-10 pubmed publisher
    ..However, the molecular basis of the aggregation of mitochondria by KLC3 and its role in sperm tail midpiece formation are not clear...
  7. Riparbelli M, Callaini G. Detachment of the basal body from the sperm tail is not required to organize functional centrosomes during Drosophila embryogenesis. Cytoskeleton (Hoboken). 2010;67:251-8 pubmed publisher
    ..We have found that the sperm centriole remains linked to the apical end of the sperm tail through early development and is able to duplicate and recruit maternal components to assemble functional ..
  8. Miller G, Pitnick S. Sperm-female coevolution in Drosophila. Science. 2002;298:1230-3 pubmed
    ..Giant sperm tails are the cellular equivalent of the peacock's tail, having evolved because females evolved reproductive tracts that selectively bias paternity in favor of males with longer sperm...
  9. Suzuki Toyota F, Ito C, Toyama Y, Maekawa M, Yao R, Noda T, et al. Factors maintaining normal sperm tail structure during epididymal maturation studied in Gopc-/- mice. Biol Reprod. 2007;77:71-82 pubmed

More Information

Publications67

  1. Samant S, Ogunkua O, Hui L, Lu J, Han Y, Orth J, et al. The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail. Dev Biol. 2005;285:57-69 pubmed
    ..The Ca(2+)-dependent sperm tail curvature phenotypes, "fishhook", where abnormally high levels of sperm exhibit sharp bends in the ..
  2. Clark A, Firozi K, Justice M. Mutations in a novel locus on mouse chromosome 11 resulting in male infertility associated with defects in microtubule assembly and sperm tail function. Biol Reprod. 2004;70:1317-24 pubmed
    ..The other two alleles had different abnormalities in the 9+2 patterning of the microtubules in the sperm tail axoneme, with one containing only five of the microtubule doublets and the other containing an extra doublet...
  3. Petersen C, Aumüller G, Bahrami M, Hoyer Fender S. Molecular cloning of Odf3 encoding a novel coiled-coil protein of sperm tail outer dense fibers. Mol Reprod Dev. 2002;61:102-12 pubmed
    The outer dense fibers (ODF) are the main cytoskeletal structures of the sperm tail found in animals with internal fecundation...
  4. Schuh S, Hille B, Babcock D. Adenosine and catecholamine agonists speed the flagellar beat of mammalian sperm by a non-receptor-mediated mechanism. Biol Reprod. 2007;77:960-9 pubmed
    ..Instead, adenosine and analogs may be transported into sperm via equilibrative and concentrative nucleoside transporters to act on unknown intracellular targets...
  5. Rivkin E, Eddy E, Willis W, Goulding E, Suganuma R, Yanagimachi R, et al. Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene. Mol Reprod Dev. 2005;72:259-71 pubmed
    ..displayed vesicles with random in situ motion, suggesting a transport impediment toward the distal end of the sperm tail. All mutant mice were fertile...
  6. Carr D, Newell A. The role of A-kinase anchoring proteins (AKaps) in regulating sperm function. Soc Reprod Fertil Suppl. 2007;63:135-41 pubmed
    ..Thus AKAPs and AKAP associated proteins appear to be key molecules in the biochemical machinery regulating the functions of flagella and cilia...
  7. Publicover S, Harper C, Barratt C. [Ca2+]i signalling in sperm--making the most of what you've got. Nat Cell Biol. 2007;9:235-42 pubmed
    ..Strangely, in a cell with few organelles and minimal cytoplasmic volume, internal Ca(2+) concentration, [Ca(2+)](i), regulates almost all these activities. How does such a simple cell achieve this - and is it as simple as it seems?..
  8. Pattarini J, Starmer W, Bjork A, Pitnick S. Mechanisms underlying the sperm quality advantage in Drosophila melanogaster. Evolution. 2006;60:2064-80 pubmed
    ..Our results exemplify that primary sex cells can bear secondary sexual straits...
  9. Soares J, Glina S, Antunes N, Wonchockier R, Galuppo A, Mizrahi F. Sperm tail flexibility test: a simple test for selecting viable spermatozoa for intracytoplasmic sperm injection from semen samples without motile spermatozoa. Rev Hosp Clin Fac Med Sao Paulo. 2003;58:250-3 pubmed
    ..The objective was to describe the results of the injection of immotile spermatozoa with flexible tails when only immotile spermatozoa are present in the semen sample...
  10. Wood C, Darszon A, Whitaker M. Speract induces calcium oscillations in the sperm tail. J Cell Biol. 2003;161:89-101 pubmed
    ..Sperm are highly polarized cells. Our results indicate that a clear understanding of the link between [Ca2+]i and sperm motility will only be gained by analysis of [Ca2+]i signals at the level of the single sperm...
  11. Buffone M, Ijiri T, Cao W, Merdiushev T, Aghajanian H, Gerton G. Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility. Mol Reprod Dev. 2012;79:4-18 pubmed publisher
    ..Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems...
  12. Noguchi T, Koizumi M, Hayashi S. Sustained elongation of sperm tail promoted by local remodeling of giant mitochondria in Drosophila. Curr Biol. 2011;21:805-14 pubmed publisher
    ..Sperm cell elongation can proceed in the absence of an axoneme, suggesting that a mechanism besides intraflagellar transport emerged to sustain it...
  13. Pang M, You Y, Park Y, Oh S, Kim D, Kim Y. Numerical chromosome abnormalities are associated with sperm tail swelling patterns. Fertil Steril. 2010;94:1012-20 pubmed publisher
    To assess whether the differential sperm tail swelling patterns observed following hypo-osmotic shock are useful in discriminating normal sperm from aneuploid sperm.
  14. Neesen J, Hartwich T, Brandhorst G, Aumüller G, Gläser B, Burfeind P, et al. Tep22, a novel testicular expressed gene, is involved in the biogenesis of the acrosome and the midpiece of the sperm tail. Biochem Biophys Res Commun. 2002;297:737-48 pubmed
    ..Taken together, our results suggest that Tep22 is involved in the biogenesis of the acrosome as well as in the function of the midpiece of murine spermatozoa...
  15. Cosson J, Huitorel P, Gagnon C. How spermatozoa come to be confined to surfaces. Cell Motil Cytoskeleton. 2003;54:56-63 pubmed
    ..The model we have developed depicts how this tri-dimensional component tends to keep spermatozoa close to interfaces and, as a consequence, increases the time of contact between the egg surface and spermatozoa...
  16. Escalier D. Knockout mouse models of sperm flagellum anomalies. Hum Reprod Update. 2006;12:449-61 pubmed
    ..The mutant mice we present in this review are invaluable models, which can be used to identify potential candidate genes for infertile men with specific sperm flagellum anomalies...
  17. Sironen A, Thomsen B, Andersson M, Ahola V, Vilkki J. An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig. Proc Natl Acad Sci U S A. 2006;103:5006-11 pubmed
    ..These findings show that the KPL2 gene is important for correct axoneme development and provide insight into abnormal sperm development and infertility disorders...
  18. Feiden S, Stypa H, Wolfrum U, Wegener G, Kamp G. A novel pyruvate kinase (PK-S) from boar spermatozoa is localized at the fibrous sheath and the acrosome. Reproduction. 2007;134:81-95 pubmed
    ..In the principal piece, both polyclonal anti-PK-M1 and anti-PK-S were found at the fibrous sheath. Our results suggest that PK-S is a major component in the structural organization of glycolysis in boar spermatozoa...
  19. Nakano I, Kobayashi T, Yoshimura M, Shingyoji C. Central-pair-linked regulation of microtubule sliding by calcium in flagellar axonemes. J Cell Sci. 2003;116:1627-36 pubmed
    ..This mechanism might control the switching of the dynein activity within the axoneme to induce the oscillatory bending movement of the flagellum...
  20. Rosales J, Lee B, Modarressi M, Sarker K, Lee K, Jeong Y, et al. Outer dense fibers serve as a functional target for Cdk5.p35 in the developing sperm tail. J Biol Chem. 2004;279:1224-32 pubmed
    ..In vitro ODF phosphorylation by Cdk5.p35 and decreased in vivo sperm tail ODF phosphorylation in p35-deficient mice indicate that Cdk5...
  21. Lishko P, Botchkina I, Kirichok Y. Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011;471:387-91 pubmed publisher
  22. Sironen A, Kotaja N, Mulhern H, Wyatt T, Sisson J, Pavlik J, et al. Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biol Reprod. 2011;85:690-701 pubmed publisher
    ..Taken together, the data in this study demonstrate that SPEF2 is required for cilia function and identify a new genetic cause of PCD in mice...
  23. Mukai C, Okuno M. Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod. 2004;71:540-7 pubmed
    ..The present results suggest that glycolysis has an unexpectedly important role in providing the ATP required for sperm motility throughout the length of the sperm flagellum...
  24. Olson G, Winfrey V, Hill K, Burk R. Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats. Reproduction. 2004;127:335-42 pubmed
    ..These data suggest that the known loss of male fertility in selenium deficiency results from the sequential development of sperm defects expressed during both spermiogenesis and maturation in the epididymis...
  25. Smith D, Gaffney E, Gadêlha H, Kapur N, Kirkman Brown J. Bend propagation in the flagella of migrating human sperm, and its modulation by viscosity. Cell Motil Cytoskeleton. 2009;66:220-36 pubmed publisher
    ..Assessment of motility in physiological viscosities will be essential in future basic research, studies of chemotaxis and novel diagnostics...
  26. Jamsai D, Bianco D, Smith S, Merriner D, Ly Huynh J, Herlihy A, et al. Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Reproduction. 2008;135:751-9 pubmed publisher
    ..spermatocytes and was up-regulated in round spermatids before being incorporated into the principal piece of the sperm tail where it co-localized with CRISP2...
  27. Darszon A, Guerrero A, Galindo B, Nishigaki T, Wood C. Sperm-activating peptides in the regulation of ion fluxes, signal transduction and motility. Int J Dev Biol. 2008;52:595-606 pubmed publisher
    ..All cilia and flagella have a conserved axonemal structure and thus understanding how Ca2+ regulates cilia and flagella beating is a fundamental question...
  28. Kim Y, Jha K, Mandal A, Vanage G, Farris E, Snow P, et al. Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. Dev Biol. 2005;286:46-56 pubmed
  29. Zheng Y, Zhang J, Wang L, Zhou Z, Xu M, Li J, et al. Cloning and characterization of a novel sperm tail protein, NYD-SP28. Int J Mol Med. 2006;18:1119-25 pubmed
    In this study, a gene coding a novel human sperm tail protein named NYD-SP28 was cloned and characterized using a complementary DNA (cDNA) microarray. Its expression was 3...
  30. Tarnasky H, Cheng M, Ou Y, Thundathil J, Oko R, van der Hoorn F. Gene trap mutation of murine outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerism. BMC Dev Biol. 2010;10:67 pubmed publisher
  31. Elgeti J, Kaupp U, Gompper G. Hydrodynamics of sperm cells near surfaces. Biophys J. 2010;99:1018-26 pubmed publisher
    ..Moreover, the model suggests a mechanism by which sperm navigate in a chemical gradient via a change of their shape...
  32. Hui L, Lu J, Han Y, Pilder S. The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities. Biol Reprod. 2006;74:633-43 pubmed
    ..TSGA2 polypeptides in sperm protein extracts; and 5) the apparent distribution of these polypeptides in major sperm tail structures...
  33. Harayama H, Muroga M, Miyake M. A cyclic adenosine 3',5'-monophosphate-induced tyrosine phosphorylation of Syk protein tyrosine kinase in the flagella of boar spermatozoa. Mol Reprod Dev. 2004;69:436-47 pubmed
    ..Based on these findings, we have concluded that the cAMP-PKA signaling is linked to the Ca2+-independent tyrosine phosphorylation of Syk in the connecting and principal pieces of boar spermatozoa...
  34. Maier B, Medrano S, Sleight S, Visconti P, Scrable H. Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail. Biol Reprod. 2003;68:67-76 pubmed
    ..These results support a role for arc and the actin cytoskeleton in the acrosome formation, the sperm acrosome reaction, and in sperm cell motility...
  35. Kierszenbaum A. Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail. Mol Reprod Dev. 2002;63:1-4 pubmed
    ..manchette (Sak57/K5 and TBP-1, the latter a component of the 26S proteasome) repositioned to the centrosome and sperm tail once the manchette disassembled...
  36. Qi Y, Jiang M, Yuan Y, Bi Y, Zheng B, Guo X, et al. ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis. Mol Hum Reprod. 2013;19:327-35 pubmed publisher
    ..In conclusion, we propose that Arl3 is a novel manchette-related protein with an important role in spermiogenesis...
  37. Vladić T, Afzelius B, Bronnikov G. Sperm quality as reflected through morphology in salmon alternative life histories. Biol Reprod. 2002;66:98-105 pubmed
    ..This study tested the following hypotheses: 1) different intensities of sperm competition may reflect different sperm tail optima; 2) long spermatozoa are superior to short ones, with an associated cost on sperm longevity; and 3) a ..
  38. Kwitny S, Klaus A, Hunnicutt G. The annulus of the mouse sperm tail is required to establish a membrane diffusion barrier that is engaged during the late steps of spermiogenesis. Biol Reprod. 2010;82:669-78 pubmed publisher
    ..is a higher order septin cytoskeletal structure located between the midpiece and principal piece regions of the sperm tail. The annulus has been hypothesized to generate the diffusion barrier that exists between these two membrane ..
  39. Lehti M, Kotaja N, Sironen A. KIF3A is essential for sperm tail formation and manchette function. Mol Cell Endocrinol. 2013;377:44-55 pubmed publisher
    ..In this study, we show that depletion of KIF3A causes severe impairments in sperm tail formation and interestingly, it also affects manchette organization and the shaping of sperm heads...
  40. Soler D, Kadunganattil S, Ramdas S, Myers K, Roca J, Slaughter T, et al. Expression of transgenic PPP1CC2 in the testis of Ppp1cc-null mice rescues spermatid viability and spermiation but does not restore normal sperm tail ultrastructure, sperm motility, or fertility. Biol Reprod. 2009;81:343-52 pubmed publisher
  41. Shiba K, Baba S, Inoue T, Yoshida M. Ca2+ bursts occur around a local minimal concentration of attractant and trigger sperm chemotactic response. Proc Natl Acad Sci U S A. 2008;105:19312-7 pubmed publisher
    ..We concluded that Ca(2+) bursts induced around a local minimal SAAF concentration trigger a sequence of flagellar responses comprising quick turning followed by straight swimming to direct spermatozoa efficiently toward eggs...
  42. Liu D, Clarke G, Baker H. Tyrosine phosphorylation on capacitated human sperm tail detected by immunofluorescence correlates strongly with sperm-zona pellucida (ZP) binding but not with the ZP-induced acrosome reaction. Hum Reprod. 2006;21:1002-8 pubmed
    ..The aim of this study was to determine whether the TP of capacitated sperm is a useful marker for the ability of sperm to bind to the ZP and undergo the ZP-induced acrosome reaction (AR)...
  43. Egydio de Carvalho C, Tanaka H, Iguchi N, Ventelä S, Nojima H, Nishimune Y. Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1. Biol Reprod. 2002;66:785-95 pubmed
    ..SHIPPO 1 in sperm is resistant to treatment with nonionic detergents and coextracted with the cytoskeletal core proteins of the mouse sperm tail.
  44. Sapiro R, Kostetskii I, Olds Clarke P, Gerton G, Radice G, Strauss III J. Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Mol Cell Biol. 2002;22:6298-305 pubmed
    ..The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia...
  45. Brown P, Miki K, Harper D, Eddy E. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003;68:2241-8 pubmed
    ..These results suggest that AKAP3 is involved in organizing the basic structure of the fibrous sheath, whereas AKAP4 has a major role in completing fibrous sheath assembly...
  46. Turner R. Tales from the tail: what do we really know about sperm motility?. J Androl. 2003;24:790-803 pubmed
  47. Hoyer Fender S, Neesen J, Szpirer J, Szpirer C. Genomic organisation and chromosomal assignment of ODF2 (outer dense fiber 2), encoding the main component of sperm tail outer dense fibers and a centrosomal scaffold protein. Cytogenet Genome Res. 2003;103:122-7 pubmed
    ODF2 (outer dense fiber 2) was first described as the main protein component of the sperm tail cytoskeleton, the outer dense fibers, but was shown recently to be a component of the centrosomal scaffold in chicken...
  48. Birkhead T, Pellatt E, Brekke P, Yeates R, Castillo Juarez H. Genetic effects on sperm design in the zebra finch. Nature. 2005;434:383-7 pubmed
    ..These results have important implications for the evolution of sperm in other taxa...
  49. Iida H, Honda Y, Matsuyama T, Shibata Y, Inai T. Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa. Mol Reprod Dev. 2006;73:929-36 pubmed
    ..Our data strongly suggested that Tektin 4 is not associated with axonemal tubulins but an ODFs-affiliated molecule in rodent spermatozoa...
  50. Behnam B, Modarressi M, Conti V, Taylor K, Puliti A, Wolfe J. Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division. Biochem Biophys Res Commun. 2006;344:1102-10 pubmed
    Tsga10 has been localised in sperm tail as a fibrous sheath protein. In this study, we showed its expression during developmental stages of mouse embryo, in adult mice brain, and in some malignancies...
  51. Li Y, He W, Jha K, Klotz K, Kim Y, Mandal A, et al. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. J Biol Chem. 2007;282:34104-19 pubmed
    ..Due to its temporal appearance during spermiogenesis and location at the cortex of the fibrous sheath, FSCB is postulated to be involved in the later stages of fibrous sheath assembly...
  52. Lee L, Campagna D, Pinkus J, Mulhern H, Wyatt T, Sisson J, et al. Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. Mol Cell Biol. 2008;28:949-57 pubmed
    ..This study demonstrates that Pcdp1 plays an important role in ciliary and flagellar biogenesis and motility, making the nm1054 mutant a useful model for studying the molecular genetics and pathogenesis of PCD...
  53. Hoyle H, Turner F, Raff E. Axoneme-dependent tubulin modifications in singlet microtubules of the Drosophila sperm tail. Cell Motil Cytoskeleton. 2008;65:295-313 pubmed publisher
    ..We compared tubulin modifications in the 9 + 9 + 2 insect sperm tail axonemes of Drosophila with the canonical 9 + 2 axonemes of sperm of the sea urchin Lytichinus pictus and the 9 +..
  54. Hayashi S, Shingyoji C. Mechanism of flagellar oscillation-bending-induced switching of dynein activity in elastase-treated axonemes of sea urchin sperm. J Cell Sci. 2008;121:2833-43 pubmed publisher
    ..Our results show that the combination of the direction of bending and the conformational state of dynein-microtubule interaction induce the switching of the dynein activity in flagella, thus providing the basis for flagellar oscillation...
  55. Ford W. Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?. Hum Reprod Update. 2006;12:269-74 pubmed
    ..In most species, it is unlikely that local glycolysis is the only way that ATP can be supplied to the distal flagellum...
  56. Nicastro D, Schwartz C, Pierson J, Gaudette R, Porter M, McIntosh J. The molecular architecture of axonemes revealed by cryoelectron tomography. Science. 2006;313:944-8 pubmed
    ..Periodic densities were also observed inside doublet microtubules; these may contribute to doublet stability...
  57. Kim Y, Haidl G, Schaefer M, Egner U, Mandal A, Herr J. Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. Dev Biol. 2007;302:463-76 pubmed
  58. Nielsen M, Raff E. The best of all worlds or the best possible world? Developmental constraint in the evolution of beta-tubulin and the sperm tail axoneme. Evol Dev. 2002;4:303-15 pubmed
    ..We present experimental data documenting developmental constraint in the assembly of the motile sperm tail axoneme. The 9+2 microtubule architecture of the eukaryotic axoneme has been deeply conserved...