spermatozoa

Summary

Summary: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.

Top Publications

  1. Krutskikh A, Poliandri A, Cabrera Sharp V, Dacheux J, Poutanen M, Huhtaniemi I. Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility. FASEB J. 2012;26:4198-209 pubmed publisher
    Eutherian spermatozoa are dependent on the environment of the proximal epididymis to complete their maturation; however, no specific epididymal factors that mediate this process have so far been identified...
  2. Matzuk M, McKeown M, Filippakopoulos P, Li Q, Ma L, Agno J, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012;150:673-84 pubmed
    ..Treatment of mice with JQ1 reduced seminiferous tubule area, testis size, and spermatozoa number and motility without affecting hormone levels...
  3. Reid A, Lord T, Stanger S, Roman S, McCluskey A, Robinson P, et al. Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. J Biol Chem. 2012;287:37659-72 pubmed publisher
    Mammalian spermatozoa must complete an acrosome reaction prior to fertilizing an oocyte...
  4. Parker G, Birkhead T. Polyandry: the history of a revolution. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120335 pubmed publisher
  5. Aitken R, Bronson R, Smith T, De Iuliis G. The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies. Mol Hum Reprod. 2013;19:475-85 pubmed publisher
    This article considers the origins of DNA damage in human spermatozoa, the methods that are available to monitor this aspect of semen quality and the clinical significance of such measurements...
  6. Chauvigné F, Boj M, Vilella S, Finn R, Cerdà J. Subcellular localization of selectively permeable aquaporins in the male germ line of a marine teleost reveals spatial redistribution in activated spermatozoa. Biol Reprod. 2013;89:37 pubmed publisher
    ..seabream, water and fluid homeostasis associated with testicular physiology and the external activation of spermatozoa is potentially mediated by multiple aquaporins...
  7. Schillaci R, Capra G, Bellavia C, Ruvolo G, Scazzone C, Venezia R, et al. Detection of oncogenic human papillomavirus genotypes on spermatozoa from male partners of infertile couples. Fertil Steril. 2013;100:1236-40 pubmed publisher
    ..Oncogenic HPV genotypes were detected on spermatozoa from asymptomatic subjects, but a role of the infection in male infertility was not demonstrated.
  8. Ji G, Yan L, Liu W, Qu J, Gu A. OGG1 Ser326Cys polymorphism interacts with cigarette smoking to increase oxidative DNA damage in human sperm and the risk of male infertility. Toxicol Lett. 2013;218:144-9 pubmed publisher
    ..0003). These findings provided the first evidence about potential interactive effects of OGG1 polymorphism and cigarette smoking on male infertility risk. ..
  9. Hulak M, Gazo I, Shaliutina A, Linhartova P. In vitro effects of bisphenol A on the quality parameters, oxidative stress, DNA integrity and adenosine triphosphate content in sterlet (Acipenser ruthenus) spermatozoa. Comp Biochem Physiol C Toxicol Pharmacol. 2013;158:64-71 pubmed publisher
    ..parameters, oxidative stress, the DNA integrity and intracellular ATP content of sterlet (Acipenser ruthenus) spermatozoa were investigated in vitro...

More Information

Publications101 found, 100 shown here

  1. Baker M, Nixon B, Naumovski N, Aitken R. Proteomic insights into the maturation and capacitation of mammalian spermatozoa. Syst Biol Reprod Med. 2012;58:211-7 pubmed publisher
    b>Spermatozoa represent the epitome of terminally differentiated, highly specialized cells...
  2. Coy P, Garcia Vazquez F, Visconti P, Aviles M. Roles of the oviduct in mammalian fertilization. Reproduction. 2012;144:649-60 pubmed publisher
    ..After a long journey, the spermatozoa meet the oocyte in the specific site of the oviduct named ampulla and fertilization takes place...
  3. de la Vega Beltrán J, Sanchez Cardenas C, Krapf D, Hernández González E, Wertheimer E, Trevino C, et al. Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction. J Biol Chem. 2012;287:44384-93 pubmed publisher
    ..Altogether, these results suggest that sperm hyperpolarization by itself is key to enabling mice sperm to undergo the acrosome reaction. ..
  4. Wei Y, Yang C, Wei Y, Zhao Z, Hou Y, Schatten H, et al. Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc Natl Acad Sci U S A. 2014;111:1873-8 pubmed publisher
    ..Our study uniquely revealed that prediabetes can be inherited transgenerationally through the mammalian germ line by an epigenetic mechanism. ..
  5. Lüpold S, Manier M, Berben K, Smith K, Daley B, Buckley S, et al. How multivariate ejaculate traits determine competitive fertilization success in Drosophila melanogaster. Curr Biol. 2012;22:1667-72 pubmed publisher
  6. Harayama H, Noda T, Ishikawa S, Shidara O. Relationship between cyclic AMP-dependent protein tyrosine phosphorylation and extracellular calcium during hyperactivation of boar spermatozoa. Mol Reprod Dev. 2012;79:727-39 pubmed publisher
    In mammalian spermatozoa, the state of protein tyrosine phosphorylation is modulated by protein tyrosine kinases and protein tyrosine phosphatases that are controlled via cyclic AMP (cAMP)-protein kinase A (PKA) signaling cascades...
  7. Valcarce D, Cartón García F, Riesco M, Herraez M, Robles V. Analysis of DNA damage after human sperm cryopreservation in genes crucial for fertilization and early embryo development. Andrology. 2013;1:723-30 pubmed publisher
    ..The assessment after freezing/thawing of spermatozoa viability, motility and sometimes DNA integrity (mainly using fragmentation assays) has been considered enough ..
  8. LaFlamme B, Wolfner M. Identification and function of proteolysis regulators in seminal fluid. Mol Reprod Dev. 2013;80:80-101 pubmed publisher
    ..We hope that this review aids researchers in pursuing a coordinated study of the functional significance of proteolysis regulators in semen. ..
  9. Huang V, Zhao W, Lee C, Lee C, Lam K, Ko J, et al. Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage. Fertil Steril. 2013;99:1444-1452.e3 pubmed publisher
    ..protective action in vitro of oviductal epithelial cell membrane proteins against oxidative damage in human spermatozoa. Prospective in vitro study. University research laboratory and infertility clinic...
  10. Ozturk S, Guzeloglu Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti M, et al. Epab and Pabpc1 are differentially expressed during male germ cell development. Reprod Sci. 2012;19:911-22 pubmed publisher
  11. Pimenta J, Domingos A, Santos P, Marques C, Cantante C, Santos A, et al. Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa. PLoS ONE. 2012;7:e42957 pubmed publisher
    ..apical ridge subdomain, before and after induced capacitation, but did not show the same behavior against goat spermatozoa, suggesting high antibody specificity against ovine-Prt...
  12. Kawano M, Kawaji H, Grandjean V, Kiani J, Rassoulzadegan M. Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos. PLoS ONE. 2012;7:e44542 pubmed publisher
    The recent discovery of a significant amount of RNA in spermatozoa contradicted the previously held belief that paternal contribution was limited to one copy of the genome...
  13. Chavez J, de la Vega Beltrán J, Escoffier J, Visconti P, Trevino C, Darszon A, et al. Ion permeabilities in mouse sperm reveal an external trigger for SLO3-dependent hyperpolarization. PLoS ONE. 2013;8:e60578 pubmed publisher
    Unlike most cells of the body which function in an ionic environment controlled within narrow limits, spermatozoa must function in a less controlled external environment...
  14. Pierre V, Martinez G, Coutton C, Delaroche J, Yassine S, Novella C, et al. Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus. Development. 2012;139:2955-65 pubmed publisher
    ..formation, which take place during the last stages of spermatogenesis, are essential to produce competent spermatozoa that are able to cross the oocyte zona pellucida and to achieve fertilization...
  15. Binder N, Hannan N, Gardner D. Paternal diet-induced obesity retards early mouse embryo development, mitochondrial activity and pregnancy health. PLoS ONE. 2012;7:e52304 pubmed publisher
  16. Erkek S, Hisano M, Liang C, Gill M, Murr R, Dieker J, et al. Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Nat Struct Mol Biol. 2013;20:868-75 pubmed publisher
    In mammalian spermatozoa, most but not all of the genome is densely packaged by protamines. Here we reveal the molecular logic underlying the retention of nucleosomes in mouse spermatozoa, which contain only 1% residual histones...
  17. Butts I, Johnson K, Wilson C, Pitcher T. Ovarian fluid enhances sperm velocity based on relatedness in lake trout, Salvelinus namaycush. Theriogenology. 2012;78:2105-2109.e1 pubmed publisher
    ..Overall, ovarian fluid enhanced sperm performance of related male fish and might act as part of a recognition system to select sperm of a specific genotype...
  18. Baker M, Naumovski N, Hetherington L, Weinberg A, Velkov T, Aitken R. Head and flagella subcompartmental proteomic analysis of human spermatozoa. Proteomics. 2013;13:61-74 pubmed publisher
    ..Given the highly differentiated, cross-linked state of spermatozoa, such studies have proven difficult to perform...
  19. Zeng X, Navarro B, Xia X, Clapham D, Lingle C. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013;142:305-13 pubmed publisher
    ..Together, KSPER and CATSPER appear to be the sole ion channels present in mouse sperm that regulate membrane potential and Ca(2+) influx in response to alkalization. ..
  20. Miro Moran A, Jardin I, Ortega Ferrusola C, Salido G, Pena F, Tapia J, et al. Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa. PLoS ONE. 2012;7:e37713 pubmed publisher
    ..We aimed to identify and to investigate the role of Epac proteins in spermatozoa using a specific permeable analog (8-Br-2'-O-Me-cAMP)...
  21. Arav A, Saragusty J. Directional freezing of spermatozoa and embryos. Reprod Fertil Dev. 2013;26:83-90 pubmed publisher
    ..The bovine sexed semen industry may benefit from the increased survival of spermatozoa after directional freezing.
  22. Smith J, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, et al. Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A. 2013;110:6823-8 pubmed publisher
    ..Although it has been suggested that progesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of sperm (CatSper), the principal flagellar Ca(2+) channel of sperm, ..
  23. Wong T, Tesfamichael A, Collodi P. Production of zebrafish offspring from cultured female germline stem cells. PLoS ONE. 2013;8:e62660 pubmed publisher
  24. Tyler F, Harrison X, Bretman A, Veen T, Rodríguez Muñoz R, Tregenza T. Multiple post-mating barriers to hybridization in field crickets. Mol Ecol. 2013;22:1640-9 pubmed publisher
  25. Menezo Y, Evenson D, Cohen M, Dale B. Effect of antioxidants on sperm genetic damage. Adv Exp Med Biol. 2014;791:173-89 pubmed publisher
    ..A detailed analysis of the sperm nucleus is mandatory (DNA fragmentation or lack of nuclear condensation) prior to any treatment. Here we discuss new concepts in OS and the corresponding therapeutic approaches. ..
  26. Kotdawala A, Kumar S, Salian S, Thankachan P, Govindraj K, Kumar P, et al. Addition of zinc to human ejaculate prior to cryopreservation prevents freeze-thaw-induced DNA damage and preserves sperm function. J Assist Reprod Genet. 2012;29:1447-53 pubmed publisher
    ..To study the effect of addition of zinc to human semen sample prior to cryopreservation on post-thaw sperm quality and function...
  27. Govindaraju A, Uzun A, Robertson L, Atli M, Kaya A, Topper E, et al. Dynamics of microRNAs in bull spermatozoa. Reprod Biol Endocrinol. 2012;10:82 pubmed publisher
    ..We demonstrated that an abundance of microRNAs were present in bovine spermatozoa, however, only seven were differentially expressed; hsa-aga-3155, -8197, -6727, -11796, -14189, -6125, -13659...
  28. Nakamura N, Dai Q, Williams J, Goulding E, Willis W, Brown P, et al. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013;88:90 pubmed publisher
    ..We conclude that ENO4 is required for normal assembly of the FS and provides most of the enolase activity in sperm and that Eno1 and/or Gm5506 may encode a minor portion of the enolase activity in sperm. ..
  29. Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, et al. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc Natl Acad Sci U S A. 2013;110:8111-6 pubmed publisher
    Formation of spermatozoa of normal shape, number, and motility is insufficient for the male siring of pups. The spermatozoa must be accompanied by sound fertilizing ability...
  30. Silva E, Patrão M, TSURUTA J, O Rand M, Avellar M. Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa. Mol Reprod Dev. 2012;79:832-42 pubmed publisher
    ..spermatogenic cells (pachytene spermatocytes and round and elongated spermatids) and in epithelial cells and spermatozoa from efferent ductules and epididymis...
  31. Cho C. Testicular and epididymal ADAMs: expression and function during fertilization. Nat Rev Urol. 2012;9:550-60 pubmed publisher
    ..It has been suggested that ADAM2 and ADAM3 have roles in sperm-egg interactions. Mouse knockout studies have revealed that the ADAM2-ADAM3 complex is critical for in vivo sperm migratory function in the female reproductive tract...
  32. Su T, Xue L, Ozcan A. High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories. Proc Natl Acad Sci U S A. 2012;109:16018-22 pubmed publisher
    ..This high-throughput 3D imaging platform could in general be quite valuable for observing the statistical swimming patterns of various other microorganisms, leading to new insights in their 3D motion and the underlying biophysics...
  33. Krausz C, Sandoval J, Sayols S, Chianese C, Giachini C, Heyn H, et al. Novel insights into DNA methylation features in spermatozoa: stability and peculiarities. PLoS ONE. 2012;7:e44479 pubmed publisher
  34. Alasmari W, Costello S, Correia J, Oxenham S, Morris J, Fernandes L, et al. Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm. J Biol Chem. 2013;288:6248-58 pubmed publisher
  35. Doshi T, D Souza C, Vanage G. Aberrant DNA methylation at Igf2-H19 imprinting control region in spermatozoa upon neonatal exposure to bisphenol A and its association with post implantation loss. Mol Biol Rep. 2013;40:4747-57 pubmed publisher
    ..F0) on the methylation of H19 imprinting control region (ICR) in resorbed embryo (F1) and compared with spermatozoa of their respective sires (F0)...
  36. Amaral S, Redmann K, Sanchez V, Mallidis C, Ramalho Santos J, Schlatt S. UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa. Andrology. 2013;1:707-14 pubmed publisher
    ..to be a good and easily manipulated in vitro model system to study mitochondria-induced oxidative stress in spermatozoa and its consequences, which may be relevant in terms of dissecting the action pathways of many other ..
  37. Lewis S, John Aitken R, Conner S, Iuliis G, Evenson D, Henkel R, et al. The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment. Reprod Biomed Online. 2013;27:325-37 pubmed publisher
    ..DNA damage in human spermatozoa is an important attribute of semen quality...
  38. Xu W, Hu H, Wang Z, Chen X, Yang F, Zhu Z, et al. Proteomic characteristics of spermatozoa in normozoospermic patients with infertility. J Proteomics. 2012;75:5426-36 pubmed publisher
    ..The observed differences in signaling and metabolic pathways between the infertile sperm and the normal fertile spermatozoa have implications in sperm motility, capacitation, acrosomal reaction and sperm-oocyte communication...
  39. Satouh Y, Inoue N, Ikawa M, Okabe M. Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1. J Cell Sci. 2012;125:4985-90 pubmed publisher
    ..However, despite its predicted function, it is not expressed on the surface of ejaculated spermatozoa. Here, we report the dynamics of diffusion of IZUMO1 from the acrosomal membrane to the sperm surface at the ..
  40. Perdrix A, Travers A, Clatot F, Sibert L, Mitchell V, Jumeau F, et al. Modification of chromosomal architecture in human spermatozoa with large vacuoles. Andrology. 2013;1:57-66 pubmed publisher
    Human normal spermatozoa present a specific chromatin organization, illustrated particularly by the non-random chromosome positioning...
  41. Aitken R, Baker M. Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development. Int J Dev Biol. 2013;57:265-72 pubmed publisher
    ..In addition, senescent mature spermatozoa can undergo a truncated form of apoptosis in order to ensure their efficient phagocytosis within the male and ..
  42. Caballero J, Frenette G, Belleannee C, Sullivan R. CD9-positive microvesicles mediate the transfer of molecules to Bovine Spermatozoa during epididymal maturation. PLoS ONE. 2013;8:e65364 pubmed publisher
    Acquisition of fertilization ability by spermatozoa during epididymal transit occurs in part by the transfer of molecules from membranous vesicles called epididymosomes...
  43. Apger McGlaughon J, Wolfner M. Post-mating change in excretion by mated Drosophila melanogaster females is a long-term response that depends on sex peptide and sperm. J Insect Physiol. 2013;59:1024-30 pubmed publisher
  44. Parte P, Rao P, Redij S, Lobo V, D Souza S, Gajbhiye R, et al. Sperm phosphoproteome profiling by ultra performance liquid chromatography followed by data independent analysis (LC-MS(E)) reveals altered proteomic signatures in asthenozoospermia. J Proteomics. 2012;75:5861-71 pubmed publisher
    ..Analyzing the phosphoenriched fractions of spermatozoa lysates from eight normozoospermic-, and asthenozoospermic-samples, respectively, by Nano UPLC-MS(E), the ..
  45. Lefievre L, Nash K, Mansell S, Costello S, Punt E, Correia J, et al. 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. Biochem J. 2012;448:189-200 pubmed publisher
    ..We propose that 2-APB-sensitive channels amplify [Ca2+]i elevation induced by progesterone (and other CatSper agonists), amplifying, propagating and providing spatio-temporal complexity in [Ca2+]i signals of human sperm...
  46. Manikkam M, Tracey R, Guerrero Bosagna C, Skinner M. Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations. Reprod Toxicol. 2012;34:708-19 pubmed publisher
    ..Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures...
  47. Kasimanickam V, Kasimanickam R, Arangasamy A, Saberivand A, Stevenson J, Kastelic J. Association between mRNA abundance of functional sperm function proteins and fertility of Holstein bulls. Theriogenology. 2012;78:2007-2019.e2 pubmed publisher
  48. Takahashi T, Kikuchi T, Kidokoro Y, Shirakawa H. Ca²? influx-dependent refilling of intracellular Ca²? stores determines the frequency of Ca²? oscillations in fertilized mouse eggs. Biochem Biophys Res Commun. 2013;430:60-5 pubmed publisher
  49. Evans J, Sherman C. Sexual selection and the evolution of egg-sperm interactions in broadcast-spawning invertebrates. Biol Bull. 2013;224:166-83 pubmed
    ..We conclude by emphasizing the excellent, but relatively untapped, potential of broadcast-spawning marine invertebrates as model systems to illuminate several areas of research in post-mating sexual selection...
  50. Bianchi E, Doe B, Goulding D, Wright G. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014;508:483-7 pubmed publisher
    ..Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives. ..
  51. Casao A, Gallego M, Abecia J, Forcada F, P rez P R, Mui o Blanco T, et al. Identification and immunolocalisation of melatonin MT(1) and MT(2) receptors in Rasa Aragonesa ram spermatozoa. Reprod Fertil Dev. 2012;24:953-61 pubmed publisher
    The reproductive seasonality of sheep suggests that melatonin receptors may be present in ram spermatozoa. The present study confirms the presence of melatonin MT(1) and MT(2) receptors...
  52. Schmid T, Eskenazi B, Marchetti F, Young S, Weldon R, Baumgartner A, et al. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril. 2012;98:1130-7.e1 pubmed publisher
    ..To investigate whether lifestyle factors such as increased dietary intake of micronutrients reduce the risks of sperm DNA damage, and whether older men benefit more than younger men...
  53. Kiso W, Asano A, Travis A, Schmitt D, Brown J, Pukazhenthi B. Pretreatment of Asian elephant (Elephas maximus) spermatozoa with cholesterol-loaded cyclodextrins and glycerol addition at 4°C improves cryosurvival. Reprod Fertil Dev. 2012;24:1134-42 pubmed publisher
    Asian elephant spermatozoa are sensitive to chilling and do not respond well to cryopreservation...
  54. Anel Lopez L, Alvarez Rodriguez M, García Alvarez O, Alvarez M, Maroto Morales A, Anel L, et al. Reduced glutathione and Trolox (vitamin E) as extender supplements in cryopreservation of red deer epididymal spermatozoa. Anim Reprod Sci. 2012;135:37-46 pubmed publisher
    ..the suitability of the antioxidants Trolox and reduced glutathione (GSH) for freezing red deer epididymal spermatozoa, aiming at improving post-thawing quality...
  55. Vigodner M, Shrivastava V, Gutstein L, Schneider J, Nieves E, Goldstein M, et al. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Hum Reprod. 2013;28:210-23 pubmed publisher
    ..Sumoylation is a type of post-translational modification that is implicated in the regulation of numerous cellular events. However, its role in the function of human sperm has not yet been characterized...
  56. Simon L, Proutski I, Stevenson M, Jennings D, McManus J, Lutton D, et al. Sperm DNA damage has a negative association with live-birth rates after IVF. Reprod Biomed Online. 2013;26:68-78 pubmed publisher
    ..The alkaline Comet assay was employed to measure sperm DNA fragmentation in native semen and in spermatozoa following density-gradient centrifugation in semen samples from 203 couples undergoing IVF and 136 couples ..
  57. Lopes Santiago B, Monteiro G, Bittencourt R, Arduino F, Ovidio P, Jordão Junior A, et al. Evaluation of sperm DNA peroxidation in fertile and subfertile dogs. Reprod Domest Anim. 2012;47 Suppl 6:208-9 pubmed publisher
    ..No significant difference was observed between groups at either time. Oral supplementation with 500 mg/day of vitamin C and 500 mg/day of vitamin E did not change the DNA peroxidation in fertile and subfertile dogs...
  58. Smith T, Dun M, Smith N, Curry B, Connaughton H, Aitken R. The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1. J Cell Sci. 2013;126:1488-97 pubmed publisher
    DNA repair has long been considered impossible in human spermatozoa due to the high level of DNA compaction observed in these cells...
  59. Klaver R, Tüttelmann F, Bleiziffer A, Haaf T, Kliesch S, Gromoll J. DNA methylation in spermatozoa as a prospective marker in andrology. Andrology. 2013;1:731-40 pubmed publisher
    Recent studies have shown associations of aberrant DNA methylation in spermatozoa with idiopathic infertility. The analysis of DNA methylation of specific genes could therefore serve as a valuable diagnostic marker in clinical andrology...
  60. Govindaraju A, Dogan S, Rodriguez Osorio N, Grant K, Kaya A, Memili E. Delivering value from sperm proteomics for fertility. Cell Tissue Res. 2012;349:783-93 pubmed publisher
    ..Viable sperm are a prerequisite for successful fertilization and beyond. Spermatozoa have a unique cell structure where haploid genomic DNA is located in a tiny cytoplasmic space in the head, ..
  61. Druart X. Sperm interaction with the female reproductive tract. Reprod Domest Anim. 2012;47 Suppl 4:348-52 pubmed publisher
  62. Lachance C, Goupil S, Leclerc P. Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity. J Cell Physiol. 2013;228:704-13 pubmed publisher
    We have recently shown that many mediators of the JAK/STAT signaling pathway are present in ejaculated human spermatozoa. Among them, STAT3 is detected mainly in membranes and flagellar cytoskeletal fractions...
  63. Simmons L, Fitzpatrick J. Sperm wars and the evolution of male fertility. Reproduction. 2012;144:519-34 pubmed publisher
    ..We argue that future research must consider sperm and seminal fluid components of the ejaculate as a functional unity. Research at the genomic level will identify the genes that ultimately control male fertility...
  64. Rosato M, Centoducati G, Santacroce M, Iaffaldano N. Effects of lycopene on in vitro quality and lipid peroxidation in refrigerated and cryopreserved turkey spermatozoa. Br Poult Sci. 2012;53:545-52 pubmed publisher
    ..However, in the presence of the highest dose of lycopene, both the viability and osmotic-resistance of chilled spermatozoa and the DNA integrity of frozen spermatozoa were similar to those of fresh spermatozoa. 4...
  65. Mudrak O, Nazarov I, Jones E, Zalensky A. Positioning of chromosomes in human spermatozoa is determined by ordered centromere arrangement. PLoS ONE. 2012;7:e52944 pubmed publisher
    ..Unlike somatic cells, human spermatozoa contain distinct spatial markers and have asymmetric nuclei which make them a unique model for localizing CHR ..
  66. Hamada A, Sharma R, du Plessis S, Willard B, Yadav S, Sabanegh E, et al. Two-dimensional differential in-gel electrophoresis-based proteomics of male gametes in relation to oxidative stress. Fertil Steril. 2013;99:1216-1226.e2 pubmed publisher
    ..To identify the relative abundance of proteins in pooled reactive oxygen species (ROS)-positive (ROS+) and ROS-negative (ROS-) semen samples with the use of two-dimensional differential in-gel electrophoresis (2D-DIGE)...
  67. Shuster S, Briggs W, Dennis P. How multiple mating by females affects sexual selection. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120046 pubmed publisher
    ..We show how such data can be collected, how often they are collected, and we explain the circumstances in which selection favouring multiple mating by females can be strong or weak. ..
  68. Manikkam M, Tracey R, Guerrero Bosagna C, Skinner M. Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS ONE. 2013;8:e55387 pubmed publisher
    ..The sperm DMR provide potential epigenetic biomarkers for transgenerational disease and/or ancestral environmental exposures...
  69. Okabe M. The cell biology of mammalian fertilization. Development. 2013;140:4471-9 pubmed publisher
    Fertilization is the process by which eggs and spermatozoa interact, achieve mutual recognition, and fuse to create a zygote, which then develops to form a new individual, thus allowing for the continuity of a species...
  70. Lambrot R, Xu C, Saint Phar S, Chountalos G, Cohen T, Paquet M, et al. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nat Commun. 2013;4:2889 pubmed publisher
    ..This model suggests epigenetic transmission may involve sperm histone H3 methylation or DNA methylation and that adequate paternal dietary folate is essential for offspring health. ..
  71. Hurtado de Llera A, Martin Hidalgo D, Gil M, Garcia Marin L, Bragado M. AMP-activated kinase AMPK is expressed in boar spermatozoa and regulates motility. PLoS ONE. 2012;7:e38840 pubmed publisher
    The main functions of spermatozoa required for fertilization are dependent on the energy status and metabolism. AMP-activated kinase, AMPK, acts a sensor and regulator of cell metabolism...
  72. Curtis M, Kirkman Brown J, Connolly T, Gaffney E. Modelling a tethered mammalian sperm cell undergoing hyperactivation. J Theor Biol. 2012;309:1-10 pubmed publisher
    ..Finally, qualitative observations drawn from experimental data of human sperm bound to excised female reproductive tract are also presented and are found to be consistent with the theoretical predictions...
  73. Peñagaricano F, Weigel K, Khatib H. Genome-wide association study identifies candidate markers for bull fertility in Holstein dairy cattle. Anim Genet. 2012;43 Suppl 1:65-71 pubmed publisher
    ..The results could contribute to the identification of genes and pathways associated with male fertility in dairy cattle...
  74. Kim S, Agca C, Agca Y. Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Cryobiology. 2012;65:215-23 pubmed publisher
    ..is an effective method of archiving valuable strains for biomedical research and handling of rat spermatozoa is very important for successful cryopreservation...
  75. Figueiras Fierro D, Acevedo J, Martínez López P, Escoffier J, Sepúlveda F, Balderas E, et al. Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm. J Cell Physiol. 2013;228:590-601 pubmed publisher
    ..These findings indicate that functional CFTR channels are present in mouse sperm and their biophysical properties are consistent with their proposed participation in capacitation...
  76. Goodrich R, Anton E, Krawetz S. Isolating mRNA and small noncoding RNAs from human sperm. Methods Mol Biol. 2013;927:385-96 pubmed
    ..A novel quality control procedure has been developed to assess the integrity and purity of the entire population of isolated mRNAs due to the absence of intact rRNAs...
  77. Rengan A, Agarwal A, van der Linde M, du Plessis S. An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet. Reprod Biol Endocrinol. 2012;10:92 pubmed publisher
    Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire...
  78. Noda T, Sakase M, Fukushima M, Harayama H. Novel approach for the detection of the vestiges of testicular mRNA splicing errors in mature spermatozoa of Japanese Black bulls. PLoS ONE. 2013;8:e57296 pubmed publisher
    ..The aim of this study was to examine the usefulness of mRNA fragments collected from ejaculated spermatozoa as alternative analytical samples for detection of the splicing errors...
  79. Turner S, Hartshorne G. Telomere lengths in human pronuclei, oocytes and spermatozoa. Mol Hum Reprod. 2013;19:510-8 pubmed publisher
    ..The aim of this study was to measure telomere lengths in individual human oocytes, spermatozoa, male and female pronuclei, in order to compare parental contributions to telomere lengths in the human zygote...
  80. Battistone M, Da Ros V, Salicioni A, Navarrete F, Krapf D, Visconti P, et al. Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases. Mol Hum Reprod. 2013;19:570-80 pubmed publisher
  81. Patel R, Al Dossary A, Stabley D, Barone C, Galileo D, Strehler E, et al. Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation. Biol Reprod. 2013;89:6 pubmed publisher
  82. Simpson J, Humphries S, Evans J, Simmons L, Fitzpatrick J. Relationships between sperm length and speed differ among three internally and three externally fertilizing species. Evolution. 2014;68:92-104 pubmed publisher
    ..We discuss these results in light of sperm competition theory and contrast the intraspecific patterns observed in this study with macroevolutionary patterns of sperm evolution reported elsewhere. ..
  83. Dias B, Ressler K. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci. 2014;17:89-96 pubmed publisher
    ..Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels. ..
  84. Xiao J, Liu Y, Li Z, Zhou Y, Lin H, Wu X, et al. Effects of the insemination of hydrogen peroxide-treated epididymal mouse spermatozoa on ?H2AX repair and embryo development. PLoS ONE. 2012;7:e38742 pubmed publisher
    Cryopreservation of human semen for assisted reproduction is complicated by cryodamage to spermatozoa caused by excessive reactive oxygen species (ROS) generation.
  85. Robinson L, Gallos I, Conner S, Rajkhowa M, Miller D, Lewis S, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod. 2012;27:2908-17 pubmed publisher
    ..Is there an association between high levels of sperm DNA damage and miscarriage?..
  86. Camprubí C, Pladevall M, Grossmann M, Garrido N, Pons M, Blanco J. Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques. Epigenetics. 2012;7:1115-24 pubmed publisher
    ..Individuals included in normal and abnormal methylation clusters were compared according to seminal parameters as well as to the outcome of assisted reproduction...
  87. Jiménez Trejo F, Tapia Rodríguez M, Cerbón M, Kuhn D, Manjarrez Gutierrez G, Mendoza Rodriguez C, et al. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction. 2012;144:677-85 pubmed publisher
    ..In conclusion, our data demonstrate the existence of components of a serotoninergic system in human sperm and support the notion for a functional role of 5-HT in mammalian sperm physiology, which can be modulated pharmacologically. ..
  88. Garolla A, Pizzol D, Bertoldo A, De Toni L, Barzon L, Foresta C. Association, prevalence, and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients. Fertil Steril. 2013;99:125-31 pubmed publisher
    ..To evaluate prevalence, association, and clearance of human papillomavirus (HPV) and antisperm antibodies (ASAs) in infected semen samples from infertile patients...
  89. Du Bois S, Len J, Parlevliet J, Eilts B. Effects of cooling time on membrane integrity and motility of frozen-thawed canine spermatozoa using two different commercial egg yolk-based extenders at two different cooldown equilibration times. Reprod Domest Anim. 2012;47 Suppl 6:278-80 pubmed publisher
    ..4) than semen cooled for 30 min in the CEYE. There was no difference in total (p = 0.8) or progressive motility (p = 0.8) between the semen cooled for 30 min in the HEYE and the semen cooled for 30 min in the CEYE...
  90. Tracey R, Manikkam M, Guerrero Bosagna C, Skinner M. Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. Reprod Toxicol. 2013;36:104-16 pubmed publisher
    ..Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures...
  91. Kingtong S, Kellner K, Bernay B, Goux D, Sourdaine P, Berthelin C. Proteomic identification of protein associated to mature spermatozoa in the Pacific oyster Crassostrea gigas. J Proteomics. 2013;82:81-91 pubmed publisher
    ..We investigated proteins associated to spermatozoa by analyzing two cellular fractions obtained from a 40-80% Percoll gradient fractioning of germ cell of mature ..
  92. Lishko P, Clapham D, Navarro B, Kirichok Y. Sperm patch-clamp. Methods Enzymol. 2013;525:59-83 pubmed publisher
    ..recently, our understanding of these important molecules was rudimentary due to the inability to patch-clamp spermatozoa and directly record the activity of these ion channels under voltage clamp...