zygote

Summary

Summary: The fertilized OVUM resulting from the fusion of a male and a female gamete.

Top Publications

  1. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  2. Harvey S, Sealy I, Kettleborough R, Fényes F, White R, STEMPLE D, et al. Identification of the zebrafish maternal and paternal transcriptomes. Development. 2013;140:2703-10 pubmed publisher
  3. Li Y, O Neill C. Persistence of cytosine methylation of DNA following fertilisation in the mouse. PLoS ONE. 2012;7:e30687 pubmed publisher
    ..is not explained by a global active loss of 5meC staining during the cleavage stage of development and global loss of methylation following fertilization is not a major component of epigenetic reprogramming in the mouse zygote.
  4. Smith Z, Chan M, Mikkelsen T, Gu H, Gnirke A, Regev A, et al. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature. 2012;484:339-44 pubmed publisher
    ..Here we generate genome-scale DNA methylation maps in mouse gametes and from the zygote through post-implantation...
  5. Sakatani M, Alvarez N, Takahashi M, Hansen P. Consequences of physiological heat shock beginning at the zygote stage on embryonic development and expression of stress response genes in cattle. J Dairy Sci. 2012;95:3080-91 pubmed publisher
    The goal was to understand the role of heat shock at the zygote stage in causing infertility. Culture at 40°C reduced the percentage of inseminated oocytes that became a morula or blastocyst by d 6 or that were a blastocyst at d 8...
  6. Salvaing J, Aguirre Lavin T, Boulesteix C, Lehmann G, Debey P, Beaujean N. 5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote. PLoS ONE. 2012;7:e38156 pubmed publisher
    In the mouse zygote, DNA methylation patterns are heavily modified, and differ between the maternal and paternal pronucleus...
  7. Griffin E, Odde D, Seydoux G. Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell. 2011;146:955-68 pubmed publisher
    ..The principles demonstrated here apply to any spatially segregated modification cycle that affects protein diffusion and do not require protein synthesis or degradation...
  8. Inoue A, Zhang Y. Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science. 2011;334:194 pubmed publisher
    ..Our study suggests that, although the conversion of 5mC to 5hmC in zygotes is an enzyme-catalyzed process, loss of 5hmC during preimplantation appears to be a DNA replication-dependent passive process...
  9. Motegi F, Zonies S, Hao Y, Cuenca A, Griffin E, Seydoux G. Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat Cell Biol. 2011;13:1361-7 pubmed publisher
    ..Our findings illustrate how microtubules, independently of actin dynamics, stimulate the self-organization of PAR proteins by providing local protection against a global barrier imposed by aPKC...

More Information

Publications82

  1. Xiong H, Mohler W, Soto M. The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote. Dev Biol. 2011;357:356-69 pubmed publisher
    Regulated movements of the nucleus are essential during zygote formation, cell migrations, and differentiation of neurons. The nucleus moves along microtubules (MTs) and is repositioned on F-actin at the cellular cortex...
  2. Siddiqui N, Li X, Luo H, Karaiskakis A, Hou H, Kislinger T, et al. Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. Genome Biol. 2012;13:R11 pubmed publisher
    ..Previous genome-wide analyses of the MZT have been restricted to whole embryos. Here we report the first such analysis for primordial germ cells (PGCs), the progenitors of the germ-line stem cells...
  3. Lindeman R, Pelegri F. Localized products of futile cycle/lrmp promote centrosome-nucleus attachment in the zebrafish zygote. Curr Biol. 2012;22:843-51 pubmed publisher
    ..Stable associations between the sperm aster and the pronuclei are essential during this directed movement...
  4. SZABO P, Pfeifer G. H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine. J Mol Cell Biol. 2012;4:427-9 pubmed publisher
  5. Chew T, Lorthongpanich C, Ang W, Knowles B, Solter D. Symmetric cell division of the mouse zygote requires an actin network. Cytoskeleton (Hoboken). 2012;69:1040-6 pubmed publisher
    ..The mouse zygote lacks discernible astral microtubules but still divides symmetrically...
  6. Mirshamsi S, Karamishabankareh H, Ahmadi Hamedani M, Soltani L, Hajarian H, Abdolmohammadi A. Combination of oocyte and zygote selection by brilliant cresyl blue (BCB) test enhanced prediction of developmental potential to the blastocyst in cattle. Anim Reprod Sci. 2013;136:245-51 pubmed publisher
    ..Directly after classification, the oocytes were maintained undisrupted in the IVP process. Zygote treatment (ZBCB): After oocyte collection, maturation and fertilization, zygotes were stained with BCB for 10min ..
  7. Niakan K, Eggan K. Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Dev Biol. 2013;375:54-64 pubmed publisher
    ..and localization of lineage-specific transcription factors in staged preimplantation human embryos from the zygote until the blastocyst...
  8. Li Y, O Neill C. 5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote. PLoS ONE. 2013;8:e63689 pubmed publisher
    ..The results are not consistent with a role for 5hmC in global demethylation in the zygote. The persistence of both modifications throughout zygotic maturation, and their differing patterns of localization ..
  9. Sebastian S, Brochet M, Collins M, Schwach F, Jones M, Goulding D, et al. A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe. 2012;12:9-19 pubmed publisher
    ..profiling of arrested parasites revealed that CDPK1 translationally activates mRNA species in the developing zygote that in macrogametes remain repressed via their 3' and 5'UTRs...
  10. Williams C, Teeling J, Perry V, Fleming T. Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biol. 2011;9:49 pubmed publisher
    ..study, we established an in vivo mouse model of maternal periconceptional systemic inflammation by intraperitoneal lipopolysaccharide (LPS) administration on the day of zygote formation and investigated the consequences into adulthood.
  11. Buettner F, Theis F. A novel approach for resolving differences in single-cell gene expression patterns from zygote to blastocyst. Bioinformatics. 2012;28:i626-i632 pubmed publisher
    ..of cells from the early mouse embryo yield gene expression data for different developmental stages from zygote to blastocyst...
  12. Kelsey G, Feil R. New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci. 2013;368:20110336 pubmed publisher
    ..Addressing these mechanisms will be essential to understanding the specificity and evolution of genomic imprinting...
  13. Biedler J, Hu W, Tae H, Tu Z. Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation. PLoS ONE. 2012;7:e33933 pubmed publisher
    ..The results of these studies are consistent with the model of early zygotic genome activation via transcriptional activators, similar to what has been found recently in Drosophila...
  14. Ruzov A, Tsenkina Y, Serio A, Dudnakova T, Fletcher J, Bai Y, et al. Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Res. 2011;21:1332-42 pubmed publisher
    ..A detectable 5-hmC signal appears in pre-implantation development starting at the zygote stage, where the paternal genome is subjected to a genome-wide hydroxylation of 5-mC, which precisely coincides ..
  15. Nien C, Liang H, Butcher S, Sun Y, Fu S, Gocha T, et al. Temporal coordination of gene networks by Zelda in the early Drosophila embryo. PLoS Genet. 2011;7:e1002339 pubmed publisher
    ..We propose that Zld promotes timely and robust transcriptional activation of early-gene networks so that developmental events are coordinated and cell fates are established properly in the cellular blastoderm embryo...
  16. Andersen I, Lindeman L, Reiner A, Østrup O, Aanes H, Alestrom P, et al. Epigenetic marking of the zebrafish developmental program. Curr Top Dev Biol. 2013;104:85-112 pubmed publisher
    ..From these observations, a concept of epigenetic prepatterning of the embryonic gene expression program prior to the onset of ZGA is emerging. The recent data collectively start shedding light on how ZGA may be programmed and regulated...
  17. Gu T, Guo F, Yang H, Wu H, Xu G, Liu W, et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011;477:606-10 pubmed publisher
    ..The paternal genome in a zygote undergoes active DNA demethylation before the first mitosis...
  18. Johnston W, Krizus A, Dennis J. Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans. Curr Biol. 2010;20:1932-7 pubmed publisher
    ..Eggshell chitin synthesis is initiated at fertilization, and chitin is deposited before the zygote exits the spermatheca...
  19. Chen J, Melton C, Suh N, Oh J, Horner K, Xie F, et al. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev. 2011;25:755-66 pubmed publisher
    ..Therefore, Cpeb1 and Dazl function in a progressive, self-reinforcing pathway to promote oocyte maturation and early embryonic development. ..
  20. Tokoro M, Shin S, Nishikawa S, Lee H, Hatanaka Y, Amano T, et al. Deposition of acetylated histones by RNAP II promoter clearance may occur at onset of zygotic gene activation in preimplantation mouse embryos. J Reprod Dev. 2010;56:607-15 pubmed
  21. Wakefield S, Lane M, Schulz S, Hebart M, Thompson J, Mitchell M. Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. Am J Physiol Endocrinol Metab. 2008;294:E425-34 pubmed
  22. Fuentes R, Fernandez J. Ooplasmic segregation in the zebrafish zygote and early embryo: pattern of ooplasmic movements and transport pathways. Dev Dyn. 2010;239:2172-89 pubmed publisher
    ..The zygote blastodisc grows by accumulation of ooplasm, transported to the animal pole from distinct sectors of ecto- and ..
  23. Polanski Z, Motosugi N, Tsurumi C, Hiiragi T, Hoffmann S. Hypomethylation of paternal DNA in the late mouse zygote is not essential for development. Int J Dev Biol. 2008;52:295-8 pubmed publisher
    ..which marks the onset of development occurs asynchronously in the mouse; paternal DNA is demethylated at the the zygote stage, whereas maternal DNA is demethylated later in development...
  24. Derijck A, van der Heijden G, Giele M, Philippens M, de Boer P. DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation. Hum Mol Genet. 2008;17:1922-37 pubmed publisher
    ..For the understanding of de novo mutation induction in the germline, mechanistic insight of DNA repair in the zygote is mandatory...
  25. Biedler J, Tu Z. Evolutionary analysis of the kinesin light chain genes in the yellow fever mosquito Aedes aegypti: gene duplication as a source for novel early zygotic genes. BMC Evol Biol. 2010;10:206 pubmed publisher
    ..AaKLC2.1 may provide a promoter for early zygotic-specific transgene expression, which is a key component of the Medea gene drive system. ..
  26. Santenard A, Ziegler Birling C, Koch M, Tora L, Bannister A, Torres Padilla M. Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3. Nat Cell Biol. 2010;12:853-62 pubmed publisher
    ..Our work demonstrates a role for a modifiable residue within a histone-variant-specific context during reprogramming and identifies a novel function for mammalian H3.3 in the initial formation of dsRNA-dependent heterochromatin. ..
  27. Guo G, Huss M, Tong G, Wang C, Li Sun L, Clarke N, et al. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010;18:675-85 pubmed publisher
    ..These results illustrate the power of single-cell expression analysis to provide insight into developmental mechanisms. The technique should be widely applicable to other biological systems. ..
  28. De Sousa P, Gardner J, Sneddon S, Pells S, Tye B, Dand P, et al. Clinically failed eggs as a source of normal human embryo stem cells. Stem Cell Res. 2009;2:188-97 pubmed publisher
    ..Our results demonstrate the viability of an alternative strategy to generate normal hESC lines from clinically failed eggs, thereby further minimizing the potential to conflict with donor reproductive interest to conceive. ..
  29. Mayer M, Depken M, Bois J, Jülicher F, Grill S. Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows. Nature. 2010;467:617-21 pubmed publisher
    ..Here we report on the subcellular distribution of cortical tension in the polarizing C. elegans zygote, which we determined using position- and direction-sensitive laser ablation...
  30. Aanes H, Winata C, Lin C, Chen J, Srinivasan K, Lee S, et al. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome Res. 2011;21:1328-38 pubmed publisher
    ..Taken together, our data constitute a useful genomic information and valuable transcriptome resource for gene discovery and for understanding the mechanisms of early embryogenesis in zebrafish. ..
  31. Yoshizawa Y, Kato M, Hirabayashi M, Hochi S. Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection. Mol Reprod Dev. 2010;77:69-75 pubmed publisher
    ..Thus, the demethylation dynamics of the paternal genome in pronuclear-stage rat zygotes was impaired by routine protocols for in vitro embryo production such as IVF and ICSI. ..
  32. Walser C, Lipshitz H. Transcript clearance during the maternal-to-zygotic transition. Curr Opin Genet Dev. 2011;21:431-43 pubmed publisher
  33. Cui C, Zhao H, Zhang Z, Zong Z, Feng C, Zhang Y, et al. CDC25B acts as a potential target of PRKACA in fertilized mouse eggs. Biol Reprod. 2008;79:991-8 pubmed publisher
    ..Our findings identify CDC25B as a potential target of PRKACA and show that PRKACA regulates G2/M transition by phosphorylating CDC25B-Ser321 but not CDC25B-Ser229 on the first mitotic division of mouse fertilized eggs. ..
  34. Wossidlo M, Nakamura T, Lepikhov K, Marques C, Zakhartchenko V, Boiani M, et al. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun. 2011;2:241 pubmed publisher
    ..A major initial event in this reprogramming is the active loss/demethylation of 5-methylcytosine (5mC) in the zygote. Here, we report on findings that link this active demethylation to molecular mechanisms...
  35. Zonies S, Motegi F, Hao Y, Seydoux G. Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2. Development. 2010;137:1669-77 pubmed publisher
    Polarization of the C. elegans zygote is initiated by ECT-2-dependent cortical flows, which mobilize the anterior PAR proteins (PAR-3, PAR-6 and PKC-3) away from the future posterior end of the embryo marked by the sperm centrosome...
  36. Watanabe T, Yachi K, Ohta T, Fukushima T, Yoshino A, Katayama Y, et al. Non-promoter hypermethylation of zygote arrest 1 (ZAR1) in human brain tumors. Brain Tumor Pathol. 2011;28:199-202 pubmed publisher
    b>Zygote arrest 1 (ZAR1) is a novel maternal-effect gene of crucial importance during the oocyte-to-embryo transition...
  37. Barton T, Robaire B, Hales B. DNA damage recognition in the rat zygote following chronic paternal cyclophosphamide exposure. Toxicol Sci. 2007;100:495-503 pubmed
    ..Little information exists on DNA damage detection in the zygote. We assessed the impact of paternal cyclophosphamide exposure on phosphorylated H2AX (gammaH2AX) and poly(ADP-..
  38. Hu T, Yu M, Zhao J. Comparative transcriptional profiling analysis of the two daughter cells from tobacco zygote reveals the transcriptome differences in the apical and basal cells. BMC Plant Biol. 2010;10:167 pubmed publisher
    ..However, because of the difficulty to isolate the in vivo apical and basal cells of two-celled proembryo from ovule and ovary in higher plants, the transcriptome analysis of them hasn't been reported...
  39. Stitzel M, Cheng K, Seydoux G. Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition. Curr Biol. 2007;17:1545-54 pubmed
    Successful transition from oocyte to zygote depends on the timely degradation of oocyte proteins to prepare for embryonic development. In C...
  40. GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed
    Mitotic spindle positioning in the Caenorhabditis elegans zygote involves microtubule-dependent pulling forces applied to centrosomes...
  41. Tsai M, Ahringer J. Microtubules are involved in anterior-posterior axis formation in C. elegans embryos. J Cell Biol. 2007;179:397-402 pubmed
    ..Our results support a role for microtubules in the induction of embryonic polarity in C. elegans...
  42. Wyman A, Pinto A, Sheridan R, Moley K. One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring. Endocrinology. 2008;149:466-9 pubmed
    ..We found that fetuses from the diabetic mice transferred at the blastocyst stage but also as early as the one-cell zygote stage displayed significantly higher rates of malformations consistent with neural tube closure problems and ..
  43. Jin S, Guo C, Pfeifer G. GADD45A does not promote DNA demethylation. PLoS Genet. 2008;4:e1000013 pubmed publisher
    ..Contrary to the previous report, we were unable to substantiate a functional role of GADD45A in DNA demethylation. The mechanism of active DNA demethylation in mammalian cells remains unknown...
  44. Daniels B, Perkins E, Dobrowsky T, Sun S, Wirtz D. Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion. J Cell Biol. 2009;184:473-9 pubmed publisher
    ..results support a heterogeneous reaction/diffusion model for PIE-1 enrichment in which the diffusion coefficient of PIE-1 is reversibly reduced in the posterior, resulting in a stable protein gradient across the zygote at steady state.
  45. Lu X, Li J, Elemento O, Tavazoie S, Wieschaus E. Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition. Development. 2009;136:2101-10 pubmed publisher
  46. Yurttas P, Morency E, Coonrod S. Use of proteomics to identify highly abundant maternal factors that drive the egg-to-embryo transition. Reproduction. 2010;139:809-23 pubmed publisher
    ..Based on these observations, we put forth the hypothesis that the mammalian oocyte contains several unique storage structures, which we have named maternal effect structures, that facilitate the oocyte-to-embryo transition...
  47. Onichtchouk D, Geier F, Polok B, Messerschmidt D, Mössner R, Wendik B, et al. Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. Mol Syst Biol. 2010;6:354 pubmed publisher
    ..The temporospatial structure of the zebrafish Pou5f1 target networks may explain aspects of the evolution of the mammalian stem cell networks...
  48. Sumiyama K, Kawakami K, Yagita K. A simple and highly efficient transgenesis method in mice with the Tol2 transposon system and cytoplasmic microinjection. Genomics. 2010;95:306-11 pubmed publisher
    ..Considering its simplicity and perfect compatibility with existing pronuclear microinjection facilities, we propose that the Tol2:CI method is applicable to high throughput functional genomics studies...
  49. Nakamura A, Shirae Kurabayashi M, Hanyu Nakamura K. Repression of early zygotic transcription in the germline. Curr Opin Cell Biol. 2010;22:709-14 pubmed publisher
    ..In this review, we will discuss the mechanisms of transcriptional repression during germ cell specification and their interspecies similarities and differences...
  50. Giraldez A. microRNAs, the cell's Nepenthe: clearing the past during the maternal-to-zygotic transition and cellular reprogramming. Curr Opin Genet Dev. 2010;20:369-75 pubmed publisher
    ..In this review, I discuss recent studies of the roles of miRNAs during the maternal-to-zygotic transition and cellular reprogramming, where they reshape transcriptional landscapes to facilitate the establishment of novel cellular states...
  51. Liu W, Liu R, Li Z. [GammaH2AX-mediated repair of DNA damaged sperm in the zygote]. Zhonghua Nan Ke Xue. 2010;16:349-53 pubmed
    ..This review aims to summarize the present knowledge on the mechanism of gammaH2AX-mediated repair of DNA damaged sperm in the zygote.
  52. Shen Orr S, Pilpel Y, Hunter C. Composition and regulation of maternal and zygotic transcriptomes reflects species-specific reproductive mode. Genome Biol. 2010;11:R58 pubmed publisher
    ..The differences in maternal contributions between animals may be associated with gene regulatory changes detectable by the size and complexity of the associated regulatory regions...
  53. Matsuoka T, Sato M, Tokoro M, Shin S, Uenoyama A, Ito K, et al. Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. J Reprod Dev. 2008;54:192-7 pubmed
    ..These results suggest that ZAG1 may be closely associated with zygotic gene expression in mouse preimplantation embryos...
  54. Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010;329:216-9 pubmed publisher
    ..These data indicate that sperm-egg recognition depends on the cleavage status of ZP2 and that binding at the surface of the zona is not sufficient to induce sperm acrosome exocytosis. ..
  55. Ma L, Xin H, Qu L, Zhao J, Yang L, Zhao P, et al. Transcription profile analysis reveals that zygotic division results in uneven distribution of specific transcripts in apical/basal cells of tobacco. PLoS ONE. 2011;6:e15971 pubmed publisher
    ..However, neither of these hypotheses has convincing support due to technical limitations...
  56. Morgan H, Jin X, Li A, Whitelaw E, O Neill C. The culture of zygotes to the blastocyst stage changes the postnatal expression of an epigentically labile allele, agouti viable yellow, in mice. Biol Reprod. 2008;79:618-23 pubmed publisher
    ..of pups expressing the active (hypomethylated) epiallele and yellow coat was significantly higher following zygote culture compared to embryos that were transferred without culture (P = 0.014) or natural matings (P < 0.001)...
  57. Patra K, Johnson J, Cantin G, Yates J, Vinetz J. Proteomic analysis of zygote and ookinete stages of the avian malaria parasite Plasmodium gallinaceum delineates the homologous proteomes of the lethal human malaria parasite Plasmodium falciparum. Proteomics. 2008;8:2492-9 pubmed publisher
    Delineation of the complement of proteins comprising the zygote and ookinete, the early developmental stages of Plasmodium within the mosquito midgut, is fundamental to understand initial molecular parasite-vector interactions...
  58. Lykke Andersen K, Gilchrist M, Grabarek J, Das P, Miska E, Zernicka Goetz M. Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. Mol Biol Cell. 2008;19:4383-92 pubmed publisher
  59. Liang H, Nien C, Liu H, Metzstein M, Kirov N, Rushlow C. The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila. Nature. 2008;456:400-3 pubmed publisher
    ..Global expression profiling confirmed that Zld has an important role in the activation of the early zygotic genome and suggests that Zld may also regulate maternal RNA degradation during the maternal-to-zygotic transition...
  60. Rice W, Gavrilets S, Friberg U. Sexually antagonistic "zygotic drive" of the sex chromosomes. PLoS Genet. 2008;4:e1000313 pubmed publisher
    ..It also fosters a new genetic hypothesis for the evolution of enigmatic fitness-reducing traits like the high frequency of spontaneous abortion, sterility, and homosexuality observed in humans...
  61. Feil R. Epigenetic asymmetry in the zygote and mammalian development. Int J Dev Biol. 2009;53:191-201 pubmed publisher
    ..Perturbation of the differential organisation of the maternally and paternally derived genomes, before fertilisation, or in the early embryo, can give rise to aberrant growth and developmental disorders in humans...
  62. Liu X, Sun Y. Microfabricated glass devices for rapid single cell immobilization in mouse zygote microinjection. Biomed Microdevices. 2009;11:1169-74 pubmed publisher
    ..of a vacuum-based cell holding device for single-cell immobilization and the use of the device in mouse zygote microinjection...
  63. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y. A role for the elongator complex in zygotic paternal genome demethylation. Nature. 2010;463:554-8 pubmed publisher
  64. Wossidlo M, Arand J, Sebastiano V, Lepikhov K, Boiani M, Reinhardt R, et al. Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. EMBO J. 2010;29:1877-88 pubmed publisher
  65. Mair G, Lasonder E, Garver L, Franke Fayard B, Carret C, Wiegant J, et al. Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development. PLoS Pathog. 2010;6:e1000767 pubmed publisher
    ..Therefore, translational repression may offer avenues as a target for the generation of transmission blocking strategies and contribute to limiting the spread of malaria. ..
  66. Jeong Y, Yeo S, Park J, Koo D, Chang W, Lee K, et al. DNA methylation state is preserved in the sperm-derived pronucleus of the pig zygote. Int J Dev Biol. 2007;51:707-14 pubmed
    ..These findings from multilateral DMR analyses provide further support to the view that DMR occurs in a non-conserved manner during early mammalian development...
  67. Iqbal K, Jin S, Pfeifer G, SZABO P. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 2011;108:3642-7 pubmed publisher
    ..Tet3, but not Tet1 or Tet2, was expressed at high levels in oocytes and zygotes, with rapidly declining levels at the two-cell stage. Our results show that 5mC oxidation is part of the early life cycle of mammals...
  68. Marchetti F, Bishop J, Lowe X, Wyrobek A. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Toxicol Sci. 2009;107:194-205 pubmed publisher
  69. Bushati N, Stark A, Brennecke J, Cohen S. Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. Curr Biol. 2008;18:501-6 pubmed publisher
    ..The finding that unrelated miRNAs regulate the maternal to zygotic transition in different animals suggests convergent evolution...
  70. Hirasawa R, Chiba H, Kaneda M, Tajima S, Li E, Jaenisch R, et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 2008;22:1607-16 pubmed publisher
    ..Consistent with these results we find that zygotic Dnmt1 is expressed in the preimplantation embryo. Thus, contrary to the previous reports, Dnmt1 alone is sufficient to maintain the methylation marks of the imprinted genes...
  71. Vastenhouw N, Zhang Y, Woods I, Imam F, Regev A, Liu X, et al. Chromatin signature of embryonic pluripotency is established during genome activation. Nature. 2010;464:922-6 pubmed publisher
    ..These results indicate that bivalent and monovalent domains might poise embryonic genes for activation and that the chromatin profile associated with pluripotency is established during the maternal-zygotic transition...
  72. Tartakoff A, Jaiswal P. Nuclear fusion and genome encounter during yeast zygote formation. Mol Biol Cell. 2009;20:2932-42 pubmed publisher
    ..After fusion, chromosome tethering keeps tagged parental genomes separate from each other. The process of NE fusion and evidence of genome independence in yeast provide a prototype for understanding related events in higher eukaryotes. ..
  73. Verhulst E, Beukeboom L, van de Zande L. Maternal control of haplodiploid sex determination in the wasp Nasonia. Science. 2010;328:620-3 pubmed publisher
    ..Upon fertilization, zygotic Nvtra transcription is initiated, which autoregulates the female-specific transcript, leading to female development...