zona pellucida

Summary

Summary: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.

Top Publications

  1. Aviles M, Gutierrez Adan A, Coy P. Oviductal secretions: will they be key factors for the future ARTs?. Mol Hum Reprod. 2010;16:896-906 pubmed publisher
    ..glycoprotein (OVGP1), a glycoprotein that is conserved in different mammals, and its association with the zona pellucida (ZP)...
  2. Tokuhiro K, Ikawa M, Benham A, Okabe M. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Proc Natl Acad Sci U S A. 2012;109:3850-5 pubmed publisher
    ..protein critical for both sperm migration from the uterus into the oviduct and sperm primary binding to the zona pellucida (ZP)...
  3. Thys M, Nauwynck H, Maes D, Hoogewijs M, Vercauteren D, Rijsselaere T, et al. Expression and putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro. Reproduction. 2009;138:471-82 pubmed publisher
    ..Endogenous Fn was detected underneath the zona pellucida (ZP) and integrin alpha(5) on the oolemma of cumulus-denuded oocytes...
  4. Stetson I, Izquierdo Rico M, Moros C, Chevret P, Lorenzo P, Ballesta J, et al. Rabbit zona pellucida composition: a molecular, proteomic and phylogenetic approach. J Proteomics. 2012;75:5920-35 pubmed publisher
    The zona pellucida (ZP) participates in sperm-egg interactions during the first steps of fertilization...
  5. Ikawa M, Inoue N, Benham A, Okabe M. Fertilization: a sperm's journey to and interaction with the oocyte. J Clin Invest. 2010;120:984-94 pubmed publisher
    ..This Review focuses on the advantages of studying fertilization using gene-manipulated animals and highlights an emerging molecular mechanism of mammalian fertilization. ..
  6. Zimmerman S, Manandhar G, Yi Y, Gupta S, Sutovsky M, Odhiambo J, et al. Sperm proteasomes degrade sperm receptor on the egg zona pellucida during mammalian fertilization. PLoS ONE. 2011;6:e17256 pubmed publisher
    ..research, the mechanism by which the fertilizing spermatozoon penetrates the mammalian vitelline membrane, the zona pellucida (ZP) remains one of the unexplained fundamental events of human/mammalian development...
  7. Goudet G, Mugnier S, Callebaut I, Monget P. Phylogenetic analysis and identification of pseudogenes reveal a progressive loss of zona pellucida genes during evolution of vertebrates. Biol Reprod. 2008;78:796-806 pubmed
    ..eggs are surrounded by an extracellular matrix with similar functions and conserved individual components: the zona pellucida (ZP) glycoproteins...
  8. Busso D, Cohen D, Maldera J, Dematteis A, Cuasnicu P. A novel function for CRISP1 in rodent fertilization: involvement in sperm-zona pellucida interaction. Biol Reprod. 2007;77:848-54 pubmed
    ..in the present study we investigated the possibility that CRISP1 plays an additional role in the sperm-zona pellucida (ZP) interaction that precedes gamete fusion...
  9. Monné M, Jovine L. A structural view of egg coat architecture and function in fertilization. Biol Reprod. 2011;85:661-9 pubmed publisher
    ..is mediated by the extracellular coat of the egg, a matrix of cross-linked glycoprotein filaments called the zona pellucida (ZP) in mammals and the vitelline envelope in nonmammals...

More Information

Publications84

  1. Madaschi C, Aoki T, de Almeida Ferreira Braga D, De Cássia Savio Figueira R, Semião Francisco L, Iaconelli A, et al. Zona pellucida birefringence score and meiotic spindle visualization in relation to embryo development and ICSI outcomes. Reprod Biomed Online. 2009;18:681-6 pubmed
    The meiotic spindle and the zona pellucida exhibit molecular order when imaged with polarized optics...
  2. Valojerdi M, Eftekhari Yazdi P, Karimian L, Hassani F, Movaghar B. Effect of laser zona thinning on vitrified-warmed embryo transfer at the cleavage stage: a prospective, randomized study. Reprod Biomed Online. 2010;20:234-42 pubmed publisher
    ..The zona pellucida of vitrified-warmed embryos in the patients of the control group was untreated, whereas in the test group it ..
  3. Shu Y, Peng W, Zhang J. Pregnancy and live birth following the transfer of vitrified-warmed blastocysts derived from zona- and corona-cell-free oocytes. Reprod Biomed Online. 2010;21:527-32 pubmed publisher
    ..and one live birth following the transfer of vitrified blastocysts developed from oocytes with neither zona pellucida nor corona cells...
  4. Naz R, Dhandapani L. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. J Reprod Immunol. 2010;84:24-31 pubmed publisher
    Sperm proteins that interact with zona pellucida 3 (ZP3) have not been clearly identified in humans. In the present study, the yeast two-hybrid (Y2H) system was used to identify human sperm proteins that interact with human ZP3...
  5. Paz G, Yavetz H, Margalit M, Hevlin Schwartz T, Amit A. [The involvement of the zona pellucida in unexplained infertile women]. Harefuah. 2008;147:77-80, 93, 92 pubmed
    ..b>Zona Pellucida (ZP) incompetence was described as one of the causes of UI...
  6. Izquierdo Rico M, Jimenez Movilla M, Llop E, Perez Oliva A, Ballesta J, Gutierrez Gallego R, et al. Hamster zona pellucida is formed by four glycoproteins: ZP1, ZP2, ZP3, and ZP4. J Proteome Res. 2009;8:926-41 pubmed publisher
    The zona pellucida (ZP) is an extracellular glycoprotein matrix that surrounds all mammalian oocytes...
  7. Caballero J, Frenette G, D Amours O, Belleann e C, Lacroix Pepin N, Robert C, et al. Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida. J Cell Physiol. 2012;227:3876-86 pubmed publisher
    ..GliPr1L1 was localized on sperm equatorial segment and neck. In vitro fertilization performed in presence of anti-GliPr1L1 showed that this protein is involved in sperm-zona pellucida interaction.
  8. Canovas S, Romar R, Grullon L, Aviles M, Coy P. Pre-fertilization zona pellucida hardening by different cross-linkers affects IVF in pigs and cattle and improves embryo production in pigs. Reproduction. 2009;137:803-12 pubmed publisher
    b>Zona pellucida (ZP) hardening (resistance to proteolysis) has been classically identified as a post-fertilization event that contributes to the block to polyspermy...
  9. Ge H, Zhou W, Zhang W, Lin J. Impact of assisted hatching on fresh and frozen-thawed embryo transfer cycles: a prospective, randomized study. Reprod Biomed Online. 2008;16:589-96 pubmed
  10. Coy P, Aviles M. What controls polyspermy in mammals, the oviduct or the oocyte?. Biol Rev Camb Philos Soc. 2010;85:593-605 pubmed publisher
    ..of spermatozoa in the proximity of the oocyte, and egg-based mechanisms, including changes in the membrane and zona pellucida (ZP) in reaction to the fertilising sperm...
  11. Suarez S. Regulation of sperm storage and movement in the mammalian oviduct. Int J Dev Biol. 2008;52:455-62 pubmed publisher
    ..Hyperactivation likely assists sperm in penetrating the cumulus matrix and is absolutely required for penetrating the oocyte zona pellucida and achieving fertilization.
  12. Sun Y, Yu H, Zhang Q, Qi J, Zhong Q, Chen Y, et al. Molecular characterization and expression pattern of two zona pellucida genes in half-smooth tongue sole (Cynoglossus semilaevis). Comp Biochem Physiol B Biochem Mol Biol. 2010;155:316-21 pubmed
    b>Zona pellucida (ZP) proteins are glycoproteins in fish chorion that are encoded by multiple gene families, mainly including zp1, zp2, and zp3...
  13. Pang P, Chiu P, Lee C, Chang L, Panico M, Morris H, et al. Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science. 2011;333:1761-4 pubmed publisher
    ..Human fertilization begins when spermatozoa bind to the extracellular matrix coating of the oocyte, known as the zona pellucida (ZP). One spermatozoan then penetrates this matrix and fuses with the egg cell, generating a zygote...
  14. Valojerdi M, Eftekhari Yazdi P, Karimian L, Ashtiani S. Effect of laser zona pellucida opening on clinical outcome of assisted reproduction technology in patients with advanced female age, recurrent implantation failure, or frozen-thawed embryos. Fertil Steril. 2008;90:84-91 pubmed
    ..To determine whether laser-assisted hatching can improve clinical outcome of assisted reproductive techniques in patients with advanced female age, with recurrent implantation failure, or who are using frozen-thawed embryos...
  15. Montag M, van der Ven H. Symposium: innovative techniques in human embryo viability assessment. Oocyte assessment and embryo viability prediction: birefringence imaging. Reprod Biomed Online. 2008;17:454-60 pubmed
    ..Birefringence imaging of the meiotic spindle and the zona pellucida in living animal and human oocytes represents a new approach in the assessment of oocyte and embryo viability...
  16. Walcher P, Cui X, Arrow J, Scobie S, Molinia F, Cowan P, et al. Bacterial ghosts as a delivery system for zona pellucida-2 fertility control vaccines for brushtail possums (Trichosurus vulpecula). Vaccine. 2008;26:6832-8 pubmed publisher
    ..Immunisation of female possums against recombinant possum zona pellucida protein-2 (ZP2) is known to reduce embryo production by 72-75% but successful development of fertility control ..
  17. Al Daghistani H, Fram K. Incidence of anti-zona pellucida and anti-sperm antibodies among infertile Jordanian women and its relation to mycoplasmas. East Mediterr Health J. 2009;15:1263-71 pubmed
    ..2% and 13.7% of infertile women, and the presence of mycoplasma was significantly correlated with the presence of AZP-Ab and ASA...
  18. Kohn M, Sztein J, Yagi R, DePamphilis M, Kaneko K. The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida. Fertil Steril. 2010;93:1533-7 pubmed publisher
    ..Because this defect could be overcome either by removal of the zona pellucida or by the presence of wild-type sperm, Dkkl1, either directly or indirectly, facilitates the ability of sperm ..
  19. Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010;329:216-9 pubmed publisher
    At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and ZP3) that surrounds eggs...
  20. Gupta S, Bhandari B. Acrosome reaction: relevance of zona pellucida glycoproteins. Asian J Androl. 2011;13:97-105 pubmed publisher
    During mammalian fertilisation, the zona pellucida (ZP) matrix surrounding the oocyte is responsible for the binding of the spermatozoa to the oocyte and induction of the acrosome reaction (AR) in the ZP-bound spermatozoon...
  21. Jimenez Movilla M, Dean J. ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida. J Cell Sci. 2011;124:940-50 pubmed publisher
    The zona pellucida contains three proteins (ZP1, ZP2, ZP3), the precursors of which possess signal peptides, 'zona' domains and short (9-15 residue) cytoplasmic tails downstream of a transmembrane domain...
  22. Gupta S, Bansal P, Ganguly A, Bhandari B, Chakrabarti K. Human zona pellucida glycoproteins: functional relevance during fertilization. J Reprod Immunol. 2009;83:50-5 pubmed publisher
    The zona pellucida (ZP), a glycoproteinaceous matrix surrounding the mammalian oocyte plays an important role in species-specific sperm-egg binding, induction of acrosome reaction in the ZP-bound spermatozoa, avoidance of polyspermy and ..
  23. Chiu P, Wong B, Lee C, Pang R, Lee K, Sumitro S, et al. Native human zona pellucida glycoproteins: purification and binding properties. Hum Reprod. 2008;23:1385-93 pubmed publisher
    Fertilization starts with the binding of the spermatozoa to the zona pellucida (ZP) of the oocyte. Such binding is a carbohydrate-mediated event and consists of a series of tightly regulated events...
  24. Goncalves R, Staros A, Killian G. Oviductal fluid proteins associated with the bovine zona pellucida and the effect on in vitro sperm-egg binding, fertilization and embryo development. Reprod Domest Anim. 2008;43:720-9 pubmed publisher
    ..protein, osteopontin (OPN), lipocalin-type prostaglandin D synthase (L-PGDS), with the bovine zona pellucida (ZP) was demonstrated by immunohistochemistry and western blot...
  25. Wassarman P, Litscher E. Mammalian fertilization: the egg's multifunctional zona pellucida. Int J Dev Biol. 2008;52:665-76 pubmed publisher
    The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma membrane of mammalian eggs. Its presence is essential for successful completion of oogenesis, fertilization and preimplantation development...
  26. Pastor L, Lucas X, Pallares J, Bernal Mañas C, Martinez E, Roca J, et al. Characterization of glycoside residues of porcine zona pellucida and ooplasm during follicular development and atresia. Mol Reprod Dev. 2008;75:1473-83 pubmed publisher
    The glycoside residues (glycoconjugates, GC) of the zona pellucida (ZP) glycoproteins are important during the first phases of fecundation...
  27. Chen K, Peschel N, Zavodska R, Sehadova H, Stanewsky R. QUASIMODO, a Novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock. Curr Biol. 2011;21:719-29 pubmed publisher
    ..Even in the additional absence of visual photoreception, partial molecular and behavioral light synchronization persists. Therefore, other important clock-related photoreceptive and synchronization mechanisms must exist...
  28. Yauger B, Boggs N, Dean J. Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Reproduction. 2011;141:313-9 pubmed publisher
    ..Mouse models are often used to study sperm-egg recognition, but the mouse zona pellucida surrounding ovulated eggs contains three proteins (ZP1, ZP2, and ZP3) whereas the human zona contains four (..
  29. Moteki H, Nishio S, Hashimoto S, Takumi Y, Iwasaki S, Takeichi N, et al. TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida domain protein secretion. J Hum Genet. 2012;57:587-92 pubmed publisher
  30. Bukovsky A, Gupta S, Bansal P, Chakravarty S, Chaudhary M, Svetlikova M, et al. Production of monoclonal antibodies against recombinant human zona pellucida glycoproteins: utility in immunolocalization of respective zona proteins in ovarian follicles. J Reprod Immunol. 2008;78:102-14 pubmed publisher
    The zona pellucida (ZP) glycoproteins play an important role in oocyte development and gamete biology...
  31. Plaza S, Chanut Delalande H, Fernandes I, Wassarman P, Payre F. From A to Z: apical structures and zona pellucida-domain proteins. Trends Cell Biol. 2010;20:524-32 pubmed publisher
    ..of extracellular matrix proteins expressed in a variety of epithelia possess a conserved region called the zona pellucida-domain (ZP domain)...
  32. Munuce M, Serravalle A, Caille A, Zumoffen C, Botti G, Cabada M, et al. Human tubal secretion can modify the affinity of human spermatozoa for the zona pellucida. Fertil Steril. 2009;91:407-13 pubmed publisher
    To study the effect of the human tubal tissue conditioned medium (CM) on sperm parameters related to sperm-zona pellucida interaction.
  33. Tardif S, Wilson M, Wagner R, Hunt P, Gertsenstein M, Nagy A, et al. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. J Biol Chem. 2010;285:24863-70 pubmed publisher
    ..acrosomal protein zonadhesin is a rapidly evolving molecule with species-specific binding activity for the egg zona pellucida (ZP)...
  34. Lin S, Hu Y, Zhu J, Woodruff T, Jardetzky T. Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding. Proc Natl Acad Sci U S A. 2011;108:5232-6 pubmed publisher
    The zona pellucida (ZP) domain is a bipartite protein structural element comprised of ZP-N and ZP-C regions...
  35. Chirinos M, Carino C, González González M, Arreola E, Reveles R, Larrea F. Characterization of human sperm binding to homologous recombinant zona pellucida proteins. Reprod Sci. 2011;18:876-85 pubmed publisher
    The union between mammalian gametes begins with the sperm binding to the zona pellucida (ZP). We studied the interaction between human sperm and ZP by using recombinant human ZP proteins (rhZP)...
  36. de Almeida Ferreira Braga D, De Cássia Savio Figueira R, Queiroz P, Madaschi C, Iaconelli A, Borges E. Zona pellucida birefringence in in vivo and in vitro matured oocytes. Fertil Steril. 2010;94:2050-3 pubmed publisher
    To evaluate zona pellucida birefringence (ZPB) in immature and mature oocytes collected after controlled ovarian stimulation and to assess the influence of ZPB on oocyte development.
  37. Jimenez Movilla M, Martínez Alonso E, Castells M, Izquierdo Rico M, Saavedra M, Gutiérrez Gallego R, et al. Cytochemical and biochemical evidences for a complex tridimensional structure of the hamster zona pellucida. Histol Histopathol. 2009;24:599-609 pubmed publisher
    b>Zona pellucida (ZP) is an extracellular matrix that surrounds eggs and pre-implantation embryos and is required for in vivo fertility. A key event in successful fertilization is sperm binding to the surface of the ZP...
  38. Jackowska M, Kempisty B, Antosik P, Bukowska D, Budna J, Lianeri M, et al. The morphology of porcine oocytes is associated with zona pellucida glycoprotein transcript contents. Reprod Biol. 2009;9:79-85 pubmed
    ..Therefore, the aim of the study was to evaluate the transcript levels of porcine zona pellucida (pZP1, pZP2, pZP3 and pZP4) glycoproteins in oocytes classified by a four-grade morphological scale (I-IV) ..
  39. Habermann F, Andre S, Kaltner H, Kübler D, Sinowatz F, Gabius H. Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy. Histochem Cell Biol. 2011;135:539-52 pubmed publisher
    ..As test system, bovine germinal vesicle oocytes with their glycoprotein envelope (zona pellucida), which presents bi- to tetraantennary complex-type N-glycans with N-acetyllactosamine repeats and core ..
  40. Familiari G, Heyn R, Relucenti M, Sathananthan H. Structural changes of the zona pellucida during fertilization and embryo development. Front Biosci. 2008;13:6730-51 pubmed
    The zona pellucida (ZP) is a unique extracellular coat surrounding the maturing oocyte, during ovulation, fertilization, and early embryo development. It is formed by three/four glycoproteins...
  41. Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 3: developmental changes in spermatid flagellum and cytoplasmic droplet and interaction of sperm with the zona pellucida and egg plasma membrane. Microsc Res Tech. 2010;73:320-63 pubmed publisher
    ..Spermatozoa move through the female reproductive tract and eventually penetrate the zona pellucida and bind to the egg plasma membrane...
  42. Kawano N, Kang W, Yamashita M, Koga Y, Yamazaki T, Hata T, et al. Mice lacking two sperm serine proteases, ACR and PRSS21, are subfertile, but the mutant sperm are infertile in vitro. Biol Reprod. 2010;83:359-69 pubmed publisher
    ..male subfertility, the mutant epididymal sperm exhibited the inability to undergo acrosomal exocytosis on the zona pellucida (ZP) surface and to traverse the ZP, thus resulting in the failure of fertilization in vitro...
  43. Michelmann H, Rath D, Töpfer Petersen E, Schwartz P. Structural and functional events on the porcine zona pellucida during maturation, fertilization and embryonic development: a scanning electron microscopy analysis. Reprod Domest Anim. 2007;42:594-602 pubmed
    ..embryos from the same, as well as from different animals, have an extremely heterogeneous morphology of the zona pellucida (ZP) surface, as shown by scanning electron microscopy...
  44. Inoue N, Satouh Y, Ikawa M, Okabe M, Yanagimachi R. Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs. Proc Natl Acad Sci U S A. 2011;108:20008-11 pubmed publisher
    ..that spermatozoa that have initiated the acrosome reaction (AR) before reaching the surface of the egg's zona pellucida (ZP) are unable to bind and penetrate the ZP...
  45. Kempisty B, Woźna M, Piotrowska H, Bukowska D, Jackowska M, Antosik P, et al. The expression of genes encoding zona pellucida glycoproteins in canine cumulus-oocyte complexes cultured in vitro in media supplemented with progesterone and estradiol. Theriogenology. 2012;77:684-93 pubmed publisher
    ..in vitro is recognized, but little is known about the influence of both steroids on the expression of zona pellucida (ZP) glycoproteins...
  46. Gadella B. The assembly of a zona pellucida binding protein complex in sperm. Reprod Domest Anim. 2008;43 Suppl 5:12-9 pubmed publisher
    ..This remodelling will result in a competent sperm that is suitably equipped to bind to the zona pellucida and to follow the processes required for fertilization...
  47. Baibakov B, Boggs N, Yauger B, Baibakov G, Dean J. Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice. J Cell Biol. 2012;197:897-905 pubmed publisher
    ..Binding to the humanized matrix was a dominant effect that resulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline space, where they were unable to fuse with mouse eggs...
  48. Litscher E, Williams Z, Wassarman P. Zona pellucida glycoprotein ZP3 and fertilization in mammals. Mol Reprod Dev. 2009;76:933-41 pubmed publisher
    An early step in mammalian fertilization is species-restricted binding of sperm to the egg's zona pellucida (ZP), a thick extracellular coat that surrounds eggs...
  49. Ueda Y, Yamaguchi R, Ikawa M, Okabe M, Morii E, Maeda Y, et al. PGAP1 knock-out mice show otocephaly and male infertility. J Biol Chem. 2007;282:30373-80 pubmed
    ..In vitro, PGAP1-deficient spermatozoa showed weak attachment to the zona pellucida and a severely diminished rate of fertilization...
  50. Hammadeh M, Fischer Hammadeh C, Ali K. Assisted hatching in assisted reproduction: a state of the art. J Assist Reprod Genet. 2011;28:119-28 pubmed publisher
    ..Artificially disrupting the zona pellucida is known as assisted hatching (AH) and there is some evidence that embryos that have undergone zona ..
  51. Yi Y, Manandhar G, Sutovsky M, Li R, Jonáková V, Oko R, et al. Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization. Biol Reprod. 2007;77:780-93 pubmed
    ..that are postranslationally modified by ubiquitination, has been implicated in acrosomal function and sperm-zona pellucida (ZP) penetration during mammalian fertilization...
  52. Yang C, Cheng C, Chen G, Liao W, Chen Y, Huang K, et al. Zona pellucida domain-containing protein ?-tectorin is crucial for zebrafish proper inner ear development. PLoS ONE. 2011;6:e23078 pubmed publisher
    The zona pellucida (ZP) domain is part of many extracellular proteins with diverse functions from structural components to receptors...
  53. Chiu P, Wong B, Lee C, Lam K, Chung M, Lee K, et al. Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx. Hum Reprod. 2010;25:2721-33 pubmed publisher
    ..b>Zona pellucida-induced acrosome reaction is crucial to fertilization and its dysfunction is a cause of male infertility...
  54. Ikawa M, Tokuhiro K, Yamaguchi R, Benham A, Tamura T, Wada I, et al. Calsperin is a testis-specific chaperone required for sperm fertility. J Biol Chem. 2011;286:5639-46 pubmed publisher
    ..infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida. Whereas CLGN was required for ADAM1A/ADAM2 dimerization and subsequent maturation of ADAM3, a sperm membrane ..
  55. Hiraoka K, Fuchiwaki M, Hiraoka K, Horiuchi T, Murakami T, Kinutani M, et al. Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective stud. J Assist Reprod Genet. 2008;25:129-35 pubmed publisher
    To evaluate the effect of the size of zona pellucida opening by laser assisted hatching for frozen cleaved embryo that were thawed after both fresh and frozen cleaved embryo transfer cycles failed and were cultured to blastocyst after ..
  56. Coy P, Canovas S, Mondéjar I, Saavedra M, Romar R, Grullon L, et al. Oviduct-specific glycoprotein and heparin modulate sperm-zona pellucida interaction during fertilization and contribute to the control of polyspermy. Proc Natl Acad Sci U S A. 2008;105:15809-14 pubmed publisher
    ..We hypothesize that zona pellucida (ZP) changes during transit of the oocyte along the oviductal ampulla modulate the interaction with ..
  57. Wassarman P. Zona pellucida glycoproteins. J Biol Chem. 2008;283:24285-9 pubmed publisher
    All mammalian eggs are surrounded by a relatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis, fertilization, and preimplantation development...
  58. Wassarman P, Litscher E. Biogenesis of the mouse egg's extracellular coat, the zona pellucida. Curr Top Dev Biol. 2013;102:243-66 pubmed publisher
    Biogenesis of the zona pellucida (ZP), the extracellular coat that surrounds all mammalian eggs, is a universal and essential feature of mammalian oogenesis and reproduction...
  59. Liu D, Sie B, Liu M, Agresta F, Baker H. Relationship between seminal plasma zinc concentration and spermatozoa-zona pellucida binding and the ZP-induced acrosome reaction in subfertile men. Asian J Androl. 2009;11:499-507 pubmed publisher
    The aim of this study was to determine the relationship between seminal zinc concentration and spermatozoa-zona pellucida (ZP) binding and the ZP-induced acrosome reaction (ZPIAR) in subfertile men...
  60. Khalilian M, Navidbakhsh M, Valojerdi M, Chizari M, Yazdi P. Estimating Young's modulus of zona pellucida by micropipette aspiration in combination with theoretical models of ovum. J R Soc Interface. 2010;7:687-94 pubmed publisher
    The zona pellucida (ZP) is the spherical layer that surrounds the mammalian oocyte...
  61. Turunen H, Sipila P, Krutskikh A, Toivanen J, Mankonen H, Hämäläinen V, et al. Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice. Biol Reprod. 2012;86:1-8 pubmed publisher
    ..However, removal of the egg zona pellucida returned the fertilization potential of the CRISP4-deficient spermatozoa, and accordingly we detected a ..
  62. Chiu P, Wong B, Chung M, Lam K, Pang R, Lee K, et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod. 2008;79:869-77 pubmed publisher
    Acrosome reaction is crucial to the penetration of spermatozoa through the zona pellucida (ZP). Glycosylation of ZP glycoproteins is important in spermatozoa-ZP interaction...
  63. Yi Y, Manandhar G, Sutovsky M, Jonáková V, Park C, Sutovsky P. Inhibition of 19S proteasomal regulatory complex subunit PSMD8 increases polyspermy during porcine fertilization in vitro. J Reprod Immunol. 2010;84:154-63 pubmed publisher
    ..electron microscopy detected PSMD8 on the surface of vesicles in the acrosomal shroud, formed as a result of zona pellucida-induced acrosomal exocytosis...
  64. Buffone M, Foster J, Gerton G. The role of the acrosomal matrix in fertilization. Int J Dev Biol. 2008;52:511-22 pubmed publisher
    ..sperm must have properly formed acrosomes to be fully functional in the process of binding and penetrating the zona pellucida (ZP), the extracellular matrix surrounding the egg...
  65. Zhao L, Reim K, Miller D. Complexin-I-deficient sperm are subfertile due to a defect in zona pellucida penetration. Reproduction. 2008;136:323-34 pubmed publisher
    Upon adhesion to the zona pellucida, sperm undergo regulated exocytosis of the acrosome. Although it is necessary for sperm to penetrate the zona pellucida and fertilize an egg, the acrosomal membrane fusion process is poorly understood...
  66. Törmälä R, Jääskeläinen M, Lakkakorpi J, Liakka A, Tapanainen J, Vaskivuo T. Zona pellucida components are present in human fetal ovary before follicle formation. Mol Cell Endocrinol. 2008;289:10-5 pubmed publisher
    The zona pellucida is a glycoprotein matrix surrounding oocytes and early-stage embryos in mammals...
  67. Santos P, Chaveiro A, Simoes N, Moreira da Silva F. Bovine oocyte quality in relation to ultrastructural characteristics of zona pellucida, polyspermic penetration and developmental competence. Reprod Domest Anim. 2008;43:685-9 pubmed publisher
    In the present study, the effect of bovine oocyte quality related to ultrastructural characteristics of zona pellucida (ZP), polyspermic penetration and embryo developmental competence was evaluated...
  68. Marco Jimenez F, Naturil Alfonso C, Jiménez Trigos E, Lavara R, Vicente J. Influence of zona pellucida thickness on fertilization, embryo implantation and birth. Anim Reprod Sci. 2012;132:96-100 pubmed publisher
    Defective sperm-zona pellucida binding and penetration are the main causes of IVF failure...
  69. Wassarman P, Litscher E. Influence of the zona pellucida of the mouse egg on folliculogenesis and fertility. Int J Dev Biol. 2012;56:833-9 pubmed publisher
    All mammalian eggs are surrounded by a relatively thick extracellular coat, called the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and preimplantation development...
  70. Gupta S, Gupta N, Suman P, Choudhury S, Prakash K, Gupta T, et al. Zona pellucida-based contraceptive vaccines for human and animal utility. J Reprod Immunol. 2011;88:240-6 pubmed publisher
    ..The zona pellucida (ZP) glycoproteins have been proposed as candidates for developing contraceptive vaccines by virtue of their ..
  71. Jennings P, Merriman J, Beckett E, Hansbro P, Jones K. Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice. Hum Reprod. 2011;26:878-84 pubmed publisher
    ..CEOs were in vitro matured, fixed and stained for chromatin and tubulin. Meiotic spindles, chromatin and the zona pellucida were all examined using confocal microscopy...
  72. Clark G. The mammalian zona pellucida: a matrix that mediates both gamete binding and immune recognition?. Syst Biol Reprod Med. 2010;56:349-64 pubmed publisher
    ..commence when spermatozoa bind to the specialized extracellular matrix of the oocyte, known as the zona pellucida (ZP)...
  73. Van Soom A, Wrathall A, Herrler A, Nauwynck H. Is the zona pellucida an efficient barrier to viral infection?. Reprod Fertil Dev. 2010;22:21-31 pubmed publisher
    ..number of viruses that are of concern, it is expedient at this time to look again at the importance of the zona pellucida (ZP) as a barrier against viruses and at the susceptibility or otherwise of embryonic cells to viral infection ..
  74. Buffone M, Rodriguez Miranda E, Storey B, Gerton G. Acrosomal exocytosis of mouse sperm progresses in a consistent direction in response to zona pellucida. J Cell Physiol. 2009;220:611-20 pubmed publisher
    Sperm acrosomal exocytosis is essential for successful fertilization, and the zona pellucida (ZP) has been classically considered as the primary initiator in vivo...
  75. Montag M, Schimming T, Koster M, Zhou C, Dorn C, Rösing B, et al. Oocyte zona birefringence intensity is associated with embryonic implantation potential in ICSI cycles. Reprod Biomed Online. 2008;16:239-44 pubmed
    ..to ICSI treatment as having either a high zona birefringence (HZB) or a low zona birefringence (LZB) of the zona pellucida. Using zona birefringence as the only selection criterion, two fertilized oocytes, preferably derived from HZB ..