decidua

Summary

Summary: The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.

Top Publications

  1. Castrechini N, Murthi P, Qin S, Kusuma G, Wilton L, Abumaree M, et al. Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reprod Sci. 2012;19:1302-14 pubmed publisher
    ..niches in a variety of tissues and here we use these markers to report the location of the MSC niche in the human decidua parietalis...
  2. Fan D, Duan J, Li M, Xu B, Li D, Jin L. The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy. Clin Immunol. 2011;141:284-92 pubmed publisher
    ..that decidual ??T cells were a CD4(-) and CD8(-) subset whose numbers increased significantly in either the decidua or peripheral blood...
  3. Harris L, Smith S, Keogh R, Jones R, Baker P, Knöfler M, et al. Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling. Am J Pathol. 2010;177:2103-15 pubmed publisher
  4. Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, et al. Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011;121:318-27 pubmed publisher
    During intrauterine life, the mammalian embryo survives via its physical connection to the mother. The uterine decidua, which differentiates from stromal cells after implantation in a process known as decidualization, plays essential ..
  5. Wetendorf M, DeMayo F. The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network. Mol Cell Endocrinol. 2012;357:108-18 pubmed publisher
    ..Furthermore, these pathways have been shown to be involved in uterine glandular development. This review highlights the integral role of uterine progesterone-mediated paracrine signaling in gland development and pregnancy. ..
  6. Zhang L, Patterson A, Zhang L, TEIXEIRA J, Pru J. Endometrial stromal beta-catenin is required for steroid-dependent mesenchymal-epithelial cross talk and decidualization. Reprod Biol Endocrinol. 2012;10:75 pubmed publisher
    ..It is concluded that beta-catenin plays an integral role in selective P?-directed epithelial-mesenchymal communication in both the estrous cycling and gravid uterus. ..
  7. Liu A, He W, Yin L, Lv P, Zhang Y, Sheng J, et al. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab. 2011;96:E493-7 pubmed publisher
    ..Proteomic analysis was performed on decidua from women with EPL, and then ER stress markers, redox status, apoptotic features, and cell viability were ..
  8. Devi Y, Seibold A, Shehu A, Maizels E, Halperin J, Le J, et al. Inhibition of MAPK by prolactin signaling through the short form of its receptor in the ovary and decidua: involvement of a novel phosphatase. J Biol Chem. 2011;286:7609-18 pubmed publisher
  9. He Y, He X, Guo P, Du M, Shao J, Li M, et al. The decidual stromal cells-secreted CCL2 induces and maintains decidual leukocytes into Th2 bias in human early pregnancy. Clin Immunol. 2012;145:161-73 pubmed publisher
    ..In the present study, we investigated roles of the decidua-derived CCL2 in Th2 predominance at maternal-fetal interface...

More Information

Publications73

  1. Lee J, Kim T, Oh S, Yoo J, Akira S, Ku B, et al. Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus. FASEB J. 2013;27:2553-63 pubmed publisher
    ..Our results suggest that STAT3 and PR crosstalk is required for successful implantation in the mouse uterus. ..
  2. Blois S, Klapp B, Barrientos G. Decidualization and angiogenesis in early pregnancy: unravelling the functions of DC and NK cells. J Reprod Immunol. 2011;88:86-92 pubmed publisher
    ..Thus, successful implantation appears to result from an interplay between cellular components of the decidualizing endometrium involving immunoregulatory and pro-angiogenic functions of DC and NK cells. ..
  3. Liang X, Zhao Z, Deng W, Tian Z, Lei W, Xu X, et al. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology. 2010;151:5007-16 pubmed publisher
    ..In this study, we first showed that Abp1 is strongly expressed in the decidua on d 5-8 of pregnancy...
  4. Dimova T, Nagaeva O, Stenqvist A, Hedlund M, Kjellberg L, Strand M, et al. Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples. Am J Reprod Immunol. 2011;66 Suppl 1:44-56 pubmed publisher
    ..We investigated Treg cells in paired decidual and peripheral blood (PB) samples from healthy women in early pregnancy and PB samples from non-pregnant women...
  5. Al Khan A, Aye I, Barsoum I, Borbely A, Cebral E, Cerchi G, et al. IFPA Meeting 2010 Workshops Report II: Placental pathology; trophoblast invasion; fetal sex; parasites and the placenta; decidua and embryonic or fetal loss; trophoblast differentiation and syncytialisation. Placenta. 2011;32 Suppl 2:S90-9 pubmed publisher
    ..5. The decidua and embryonic/fetal loss workshop focused on key regulatory mediators in the decidua, embryo and fetus and how ..
  6. Harris L. IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: key events in the remodelling timeline. Placenta. 2011;32 Suppl 2:S154-8 pubmed publisher
    ..Parallels with remodelling events occurring in other vascular beds will also be drawn...
  7. Konno T, Graham A, Rempel L, Ho Chen J, Alam S, Bu P, et al. Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Endocrinology. 2010;151:4537-50 pubmed publisher
    ..BN uterine decidua was shown to be both structurally and functionally distinct and correlated with decreased circulating ..
  8. Nancy P, Tagliani E, Tay C, Asp P, Levy D, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012;336:1317-21 pubmed publisher
    ..We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta...
  9. Zaga Clavellina V, Martha R, Flores Espinosa P. In vitro secretion profile of pro-inflammatory cytokines IL-1?, TNF-?, IL-6, and of human beta-defensins (HBD)-1, HBD-2, and HBD-3 from human chorioamniotic membranes after selective stimulation with Gardnerella vaginalis. Am J Reprod Immunol. 2012;67:34-43 pubmed publisher
    ..Preterm labor associated with infection is a major clinical condition; in this work, we analyze the response of human chorioamniotic membranes stimulated with Gardnerella vaginalis...
  10. Kuroda K, Venkatakrishnan R, Salker M, Lucas E, Shaheen F, Kuroda M, et al. Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol Endocrinol. 2013;27:192-202 pubmed publisher
  11. Snegovskikh V, Bhandari V, Wright J, Tadesse S, Morgan T, MacNeill C, et al. Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor. J Clin Endocrinol Metab. 2011;96:E624-32 pubmed publisher
    ..Recent data suggest that surfactant protein-A (SP-A) may be critical to the onset of labor in mice. Whether this is also true in humans is unclear...
  12. Kanematsu D, Shofuda T, Yamamoto A, Ban C, Ueda T, Yamasaki M, et al. Isolation and cellular properties of mesenchymal cells derived from the decidua of human term placenta. Differentiation. 2011;82:77-88 pubmed publisher
    ..In this study, we isolated plastic-adherent cells from human term decidua vera, called decidua-derived-mesenchymal cells (DMCs), and compared their properties with those of bone marrow-..
  13. Bornstein R, Macias M, de la Torre P, Grande J, Flores A. Human decidua-derived mesenchymal stromal cells differentiate into hepatic-like cells and form functional three-dimensional structures. Cytotherapy. 2012;14:1182-92 pubmed publisher
    Previously, we have shown that human decidua-derived mesenchymal stromal cells (DMSC) are mesenchymal stromal cells (MSC) with a clonal differentiation capacity for the three embryonic layers...
  14. Bondarenko G, Durning M, Golos T. Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy. Am J Reprod Immunol. 2012;68:309-21 pubmed publisher
    ..and morphological changes through immunohistological and morphometric evaluation of the endometrium throughout the menstrual cycle and the decidua during early gestation in the rhesus monkey, a tractable experimental animal model.
  15. Segerer S, Rieger L, Kapp M, Dombrowski Y, Muller N, Dietl J, et al. MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts. Hum Reprod. 2012;27:200-9 pubmed publisher
    ..So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy...
  16. Du M, Zhou W, Piao H, Li M, Tang C, Li D. Cyclosporin A promotes crosstalk between human cytotrophoblast and decidual stromal cell through up-regulating CXCL12/CXCR4 interaction. Hum Reprod. 2012;27:1955-65 pubmed publisher
    ..In this study, we further investigate the molecular mechanisms underlying modulation by CsA of the crosstalk between human cytotrophoblast and decidual stromal cell (DSC)...
  17. Stanek J, Biesiada J. Sensitivity and specificity of finding of multinucleate trophoblastic giant cells in decidua in placentas from high-risk pregnancies. Hum Pathol. 2012;43:261-8 pubmed publisher
    ..with clusters of multinucleate trophoblastic giant cell (at least 3 cells with at least 3 nuclei) in the decidua (study group) were compared with all remaining 2674 placentas concurrently studied (control group) in 20-week-or-..
  18. Yu J, Wu J, Bagchi I, Bagchi M, Sidell N, Taylor R. Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. Mol Cell Endocrinol. 2011;344:25-34 pubmed publisher
    ..Uterine decidualization is critical to embryonic implantation and sustained pregnancy...
  19. Burnum K, Hirota Y, Baker E, Yoshie M, Ibrahim Y, Monroe M, et al. Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua. Endocrinology. 2012;153:4568-79 pubmed publisher
    ..In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53...
  20. Løset M, Mundal S, Johnson M, Fenstad M, Freed K, Lian I, et al. A transcriptional profile of the decidua in preeclampsia. Am J Obstet Gynecol. 2011;204:84.e1-27 pubmed publisher
    We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis.
  21. Huyen D, Bany B. Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization. Reproduction. 2011;142:353-68 pubmed publisher
  22. Braunschweig A, Poehlmann T, Busch S, Schleussner E, Markert U. Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92. Am J Reprod Immunol. 2011;66:329-35 pubmed publisher
    ..The other cytokines were expressed at very low concentration or not constantly affected. CONCLUSION? STAT3 and SOCS3 are involved in regulation of NK cell cytotoxicity and IL-10 expression...
  23. Croy B, Chen Z, Hofmann A, Lord E, Sedlacek A, Gerber S. Imaging of vascular development in early mouse decidua and its association with leukocytes and trophoblasts. Biol Reprod. 2012;87:125 pubmed publisher
    ..Ptprc(+) (CD45(+)) cells increased in decidua between Gestational Day (GD) 5.5 and GD 9.5...
  24. Vegh I, Grau M, Gracia M, Grande J, de la Torre P, Flores A. Decidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development. Cancer Gene Ther. 2013;20:8-16 pubmed publisher
    ..Previously, we have isolated mesenchymal cells from the decidua of the human placenta named as decidua-derived MSCs (DMSCs)...
  25. Vacca P, Vitale C, Montaldo E, Conte R, Cantoni C, Fulcheri E, et al. CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells. Proc Natl Acad Sci U S A. 2011;108:2402-7 pubmed publisher
    Natural killer (NK) cells are the main lymphoid population in the maternal decidua during the first trimester of pregnancy...
  26. Shynlova O, Nedd Roderique T, Li Y, Dorogin A, Nguyen T, Lye S. Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling. J Cell Mol Med. 2013;17:311-24 pubmed publisher
    Leucocyte infiltration in the decidua (maternal-foetal interface) before, during and after term (TL) and preterm labour (PTL) was studied in mouse...
  27. Al Sabbagh M, Fusi L, Higham J, Lee Y, Lei K, Hanyaloglu A, et al. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology. 2011;152:730-40 pubmed publisher
    ..Thus, NOX-4 activation and reactive oxygen species signaling play an integral role in initiating the endometrial decidual response in preparation of pregnancy...
  28. Laskarin G, Redzovic A, Vlastelic I, Haller H, Medancic S, Solinas G, et al. Tumor-associated glycoprotein (TAG-72) is a natural ligand for the C-type lectin-like domain that induces anti-inflammatory orientation of early pregnancy decidual CD1a+ dendritic cells. J Reprod Immunol. 2011;88:12-23 pubmed publisher
    ..in secretory phase endometrium, but its presence and possible immunological role in early normal human pregnancy decidua has not received attention. The double labeling of paraffin-embedded early pregnancy decidua sections using B-72...
  29. Hamilton S, Oomomian Y, Stephen G, Shynlova O, Tower C, Garrod A, et al. Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor. Biol Reprod. 2012;86:39 pubmed publisher
    ..We hypothesized that inflammatory events in decidua (the maternal-fetal interface), characterized by leucocyte infiltration, are an early event during term and ..
  30. Laskarin G, Medancic S, Redzovic A, Duric D, Rukavina D. Specific decidual CD14(+) cells hamper cognate NK cell proliferation and cytolytic mediator expression after mucin 1 treatment in vitro. J Reprod Immunol. 2012;95:36-45 pubmed publisher
    ..Based on the experiments with first-trimester decidual cells in vitro, we conclude that removing MUC1 from decidual tissue might help control trophoblast invasion by NK cells...
  31. Volchek M, Girling J, Lash G, Cann L, Kumar B, Robson S, et al. Lymphatics in the human endometrium disappear during decidualization. Hum Reprod. 2010;25:2455-64 pubmed publisher
    ..The aim of this study was to describe the distribution of lymphatic vessels in human decidua, with particular focus on the lymphatics that surround remodelling spiral arteries during decidualization and ..
  32. Salker M, Nautiyal J, Steel J, Webster Z, Sućurović S, Nicou M, et al. Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss. PLoS ONE. 2012;7:e52252 pubmed publisher
    ..Failure to constrain this response predisposes to miscarriage by allowing out-of-phase implantation in an unsupportive uterine environment...
  33. Basta P, Majka M, Jozwicki W, Lukaszewska E, Knafel A, Grabiec M, et al. The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua. Reprod Biol Endocrinol. 2010;8:116 pubmed publisher
    ..of Treg cells in conditions where a disturbance in the immunological equilibrium in ectopic endometrium and decidua has been observed, such as in cases of ovarian endometriosis (involving local immune cell suppression) and ..
  34. Afshar Y, Jeong J, Roqueiro D, DeMayo F, Lydon J, Radtke F, et al. Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse. FASEB J. 2012;26:282-94 pubmed publisher
    ..In summary, Notch1 signaling modulates multiple signaling mechanisms crucial for decidualization and these studies provide additional perspectives to the coordination of multiple signaling modalities required during decidualization...
  35. Hayati A, Nur Fariha M, Tan G, Tan A, Chua K. Potential of human decidua stem cells for angiogenesis and neurogenesis. Arch Med Res. 2011;42:291-300 pubmed publisher
    Placenta as a fetomaternal organ is a potential source of fetal as well as maternal stem cells. This present study describes novel properties of the cells isolated from the maternal part of term placenta membrane, the decidua basalis.
  36. Sánchez Rodríguez E, Nava Salazar S, Mendoza Rodriguez C, Moran C, Romero Arauz J, Ortega E, et al. Persistence of decidual NK cells and KIR genotypes in healthy pregnant and preeclamptic women: a case-control study in the third trimester of gestation. Reprod Biol Endocrinol. 2011;9:8 pubmed publisher
    Natural Killer (NK) cells are the most abundant lymphocytes in the decidua during early gestation...
  37. Li M, Wu Z, Yang H, Huang S. NF?B and JNK/MAPK activation mediates the production of major macrophage- or dendritic cell-recruiting chemokine in human first trimester decidual cells in response to proinflammatory stimuli. J Clin Endocrinol Metab. 2011;96:2502-11 pubmed publisher
    ..IL-1?- or TNF-?-stimulated leukocyte-free first trimester decidual cells produced abundant macrophage- and dendritic cell-recruiting chemokines identified in preeclamptic decidua.
  38. Macias M, Grande J, Moreno A, Dominguez I, Bornstein R, Flores A. Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers. Am J Obstet Gynecol. 2010;203:495.e9-495.e23 pubmed publisher
    ..The objective of the study was to isolate and characterize a population of mesenchymal stem cells (MSCs) from human term placental membranes...
  39. Cha J, Sun X, Dey S. Mechanisms of implantation: strategies for successful pregnancy. Nat Med. 2012;18:1754-67 pubmed publisher
    ..Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization...
  40. Le Bouteiller P, Siewiera J, Casart Y, Aguerre Girr M, El Costa H, Berrebi A, et al. The human decidual NK-cell response to virus infection: what can we learn from circulating NK lymphocytes?. J Reprod Immunol. 2011;88:170-5 pubmed publisher
    ..viral-mediated signal(s) and molecular interactions may subvert inhibition of dNK cytotoxic potential? Does uterine viral infection promote decidual NK cell secretion of cytokines and chemokines that boost the anti-viral immune response?..
  41. Schonkeren D, van der Hoorn M, Khedoe P, Swings G, van Beelen E, Claas F, et al. Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies. Am J Pathol. 2011;178:709-17 pubmed publisher
    ..Macrophages are an abundant cell population in the human decidua, and changes in distribution or phenotype may be involved in the development of preeclampsia...
  42. Anacker J, Segerer S, Hagemann C, Feix S, Kapp M, Bausch R, et al. Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases. Mol Hum Reprod. 2011;17:637-52 pubmed publisher
    ..There is evidence for the expression of several MMPs and TIMPs in decidua. However, published data are limited...
  43. Carlino C, Trotta E, Stabile H, Morrone S, Bulla R, Soriani A, et al. Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy. J Clin Endocrinol Metab. 2012;97:3603-12 pubmed publisher
    ..Although decidual natural killer (NK) cell accumulation and vascular remodeling are critical steps to ensure successful pregnancy, the molecular mechanisms controlling these events are poorly defined...
  44. Tirado Gonzalez I, Muñoz Fernández R, Blanco O, Leno Durán E, Abadia Molina A, Olivares E. Reduced proportion of decidual DC-SIGN+ cells in human spontaneous abortion. Placenta. 2010;31:1019-22 pubmed publisher
    ..In normal decidua, DC-SIGN+ cells expressed antigens associated with immature myeloid dendritic cells...
  45. Plaisier M. Decidualisation and angiogenesis. Best Pract Res Clin Obstet Gynaecol. 2011;25:259-71 pubmed publisher
    ..This article assesses decidual vascular changes during human implantation, and evaluates the involvement of angiogenesis in the pathogenesis of miscarriages, pre-eclampsia and intrauterine growth restriction...
  46. Shahbazi M, Jeddi Tehrani M, Zareie M, Salek Moghaddam A, Akhondi M, Bahmanpoor M, et al. Expression profiling of vitamin D receptor in placenta, decidua and ovary of pregnant mice. Placenta. 2011;32:657-664 pubmed publisher
    The presence of vitamin D receptor (VDR) and the identification of localized vitamin D3 synthesis in placenta and decidua implicate the importance of vitamin D3 in reproductive function...
  47. Zhao Y, Park S, Bagchi M, Taylor R, Katzenellenbogen B. The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization. Endocrinology. 2013;154:1349-60 pubmed publisher
  48. Rudolph M, Döcke W, Müller A, Menning A, Rose L, Zollner T, et al. Induction of overt menstruation in intact mice. PLoS ONE. 2012;7:e32922 pubmed publisher
  49. Veljkovic Vujaklija D, Dominovic M, Gulic T, Mahmutefendić H, Haller H, Saito S, et al. Granulysin expression and the interplay of granulysin and perforin at the maternal-fetal interface. J Reprod Immunol. 2013;97:186-96 pubmed publisher
    ..The abundant GNLY secretion by decidual NK cells compared with peripheral blood NK cells after 2h of contact with the NK-sensitive K562 cells and K562 transfectants was striking...
  50. Teklenburg G, Salker M, Heijnen C, Macklon N, Brosens J. The molecular basis of recurrent pregnancy loss: impaired natural embryo selection. Mol Hum Reprod. 2010;16:886-95 pubmed publisher
    ..Thus, as the clinical correlate of inappropriate uterine receptivity, 'superfertility' should be considered as a genuine reproductive disorder that requires targeted intervention...
  51. Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, et al. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. PLoS ONE. 2013;8:e55226 pubmed publisher
    ..We previously reported that the pericellular matrix of decidua-derived mesenchymal cells (PCM-DM) is an ideal human-derived substrate on which to maintain hiPSCs/hESCs...
  52. Kaitu u Lino T, Ye L, Tuohey L, Dimitriadis E, Bulmer J, Rogers P, et al. Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua. Hum Reprod. 2013;28:1172-80 pubmed publisher
    ..What is the nature of cellular Corin expression in human gestational tissues?..
  53. Ramathal C, Wang W, Hunt E, Bagchi I, Bagchi M. Transcription factor CCAAT enhancer-binding protein beta (C/EBPbeta) regulates the formation of a unique extracellular matrix that controls uterine stromal differentiation and embryo implantation. J Biol Chem. 2011;286:19860-71 pubmed publisher
  54. Barnea E, Kirk D, Paidas M. Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-?2?3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua. Reprod Biol Endocrinol. 2012;10:50 pubmed publisher
    ..Herein sPIF priming effects on non-decidualized endometrium and decidualized-stroma are investigated, assessing elements critical for effective embryo-maternal cross-talk, prior to and at implantation...
  55. Manolea M, Gavrilă O, Popescu F, Novac L, Mateescu G. The importance of immunohistochemical evaluation of the vascular changes from the decidua and placenta in recurrent pregnancy loss. Rom J Morphol Embryol. 2012;53:363-8 pubmed
    ..in the control group for CD34 in the vessels from the villous axis and also in the vessels from the spongious decidua. In the study group, we found light positive reaction in the vessels from the decidua situated in the proximity ..
  56. Afshar Y, Miele L, Fazleabas A. Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates. Endocrinology. 2012;153:2884-96 pubmed publisher
    ..Subsequently, Notch1 down-regulation may be critical for the transition of stromal fibroblast to decidual cells, which is essential for the establishment of a successful pregnancy...
  57. Guo W, Li P, Zhao G, Fan H, Hu Y, Hou Y. Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells. Am J Reprod Immunol. 2012;67:463-73 pubmed publisher
    ..Uterine natural killer cells (uNK) do not express progesterone receptor, but express glucocorticoid receptor (GR). So, we speculate that progesterone may regulate uNK cells through a GR-mediated process...
  58. Houser B, Tilburgs T, Hill J, Nicotra M, Strominger J. Two unique human decidual macrophage populations. J Immunol. 2011;186:2633-42 pubmed publisher
    ..also differ from CD11c(LO) dMs in their ability to process protein Ag and are likely to be the major APCs in the decidua. Moreover, these populations each secrete both proinflammatory and anti-inflammatory cytokines that may ..
  59. Sonderegger S, Pollheimer J, Knöfler M. Wnt signalling in implantation, decidualisation and placental differentiation--review. Placenta. 2010;31:839-47 pubmed publisher
    ..Hence, much remains to be learned about the role of different Wnt signalling cascades in reproductive cell types and their changes under pathological conditions...
  60. Amodio G, Mugione A, Sanchez A, Vigano P, Candiani M, Somigliana E, et al. HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy. Hum Immunol. 2013;74:406-11 pubmed publisher
    ..We investigated the presence of DC-10 and HLA-G-expressing CD4(+) T cells in human decidua in the first trimester of pregnancy...
  61. Piao H, Tao Y, Zhu R, Wang S, Tang C, Fu Q, et al. The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy. Cell Mol Immunol. 2012;9:423-30 pubmed publisher
    ..Our present study has elucidated the individual contributions of component cells to the shaping of Th2 bias, and uncovered a complicated cross-talk via the CXCL12/CXCR4 signal at the maternal/fetal interface in early human pregnancy...
  62. Male V, Sharkey A, Masters L, Kennedy P, Farrell L, Moffett A. The effect of pregnancy on the uterine NK cell KIR repertoire. Eur J Immunol. 2011;41:3017-27 pubmed publisher
    The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast...
  63. Tirado Gonzalez I, Muñoz Fernández R, Prados A, Leno Durán E, Martin F, Abadia Molina A, et al. Apoptotic DC-SIGN+ cells in normal human decidua. Placenta. 2012;33:257-63 pubmed publisher
    Normal pregnancy and spontaneous abortion in humans and mice are associated with immune responses. The decidua harbors dendritic cells identifiable in humans by their expression of DC-SIGN...
  64. Franco H, Dai D, Lee K, Rubel C, ROOP D, Boerboom D, et al. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 2011;25:1176-87 pubmed publisher
    ..Thus, WNT4 is a critical regulator not only of proper postnatal uterine development, but also embryo implantation and decidualization...