follicular fluid

Summary

Summary: The fluid surrounding the OVUM and GRANULOSA CELLS in the Graafian follicle (OVARIAN FOLLICLE). The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes.

Top Publications

  1. Lo Turco E, Cordeiro F, Lopes P, Gozzo F, Pilau E, Soler T, et al. Proteomic analysis of follicular fluid from women with and without endometriosis: new therapeutic targets and biomarkers. Mol Reprod Dev. 2013;80:441-50 pubmed publisher
    ..The follicular fluid was collected from 21 patients undergoing in vitro-fertilization treatment, according to the following groups:..
  2. Arya B, Haq A, Chaudhury K. Oocyte quality reflected by follicular fluid analysis in poly cystic ovary syndrome (PCOS): a hypothesis based on intermediates of energy metabolism. Med Hypotheses. 2012;78:475-8 pubmed publisher
    There is no clear acceptance of specific follicular fluid biomarker and its correlation with oocyte quality or related embryo variable till now...
  3. Rizzo R, Stignani M, Melchiorri L, Baricordi O. Possible role of human leukocyte antigen-G molecules in human oocyte/embryo secretome. Hum Immunol. 2009;70:970-5 pubmed publisher
    ..A focus on the possible role of HLA-G in oocyte/embryo context will be developed in this review. In addition, the possible use of HLA-G in assisted reproductive technology will be treated. ..
  4. Bender K, Walsh S, Evans A, Fair T, Brennan L. Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. Reproduction. 2010;139:1047-55 pubmed publisher
    ..Metabolite composition of the follicular fluid, which presents the intrafollicular environment, may be an important factor affecting oocyte maturation and ..
  5. Pasqualotto E, Lara L, Salvador M, Sobreiro B, Borges E, Pasqualotto F. The role of enzymatic antioxidants detected in the follicular fluid and semen of infertile couples undergoing assisted reproduction. Hum Fertil (Camb). 2009;12:166-71 pubmed publisher
    The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development...
  6. La Vignera S, Condorelli R, Bellanca S, La Rosa B, Mousavi A, Busa B, et al. Obesity is associated with a higher level of pro-inflammatory cytokines in follicular fluid of women undergoing medically assisted procreation (PMA) programs. Eur Rev Med Pharmacol Sci. 2011;15:267-73 pubmed
    ..antibodies serum levels) on the serum concentrations of cytokines TNF-alpha, IL-6, and IL-10 in the follicular fluid of women undergoing a medically assisted procreation (PMA) cycle...
  7. Lee J, Kim S, Kim S, Jee B, Ku S, Suh C, et al. Anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation and optimal timing of measurement for outcome prediction. Hum Reprod. 2010;25:2597-604 pubmed publisher
    ..b>Follicular fluid (FF) from dominant follicles upon oocyte retrieval were also analyzed for AMH and inhibin B concentrations...
  8. Jungheim E, Macones G, Odem R, Patterson B, Lanzendorf S, Ratts V, et al. Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril. 2011;95:1970-4 pubmed publisher
    ..A total of 102 women undergoing IVF. Measurement of FFAs in serum and ovarian follicular fluid. Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and ..
  9. Ying S, Wang Z, Wang C, Nie H, He D, Jia R, et al. Effect of different levels of short-term feed intake on folliculogenesis and follicular fluid and plasma concentrations of lactate dehydrogenase, glucose, and hormones in Hu sheep during the luteal phase. Reproduction. 2011;142:699-710 pubmed publisher
    ..On days 7-12, blood samples were taken. After slaughter, the ovarian follicles were classified and the follicular fluid was collected...

More Information

Publications101 found, 100 shown here

  1. Hennet M, Yu H, Combelles C. Follicular fluid hydrogen peroxide and lipid hydroperoxide in bovine antral follicles of various size, atresia, and dominance status. J Assist Reprod Genet. 2013;30:333-40 pubmed publisher
    ..Previous studies have examined ROS levels in follicular fluid (FF) using pooled samples or according to follicle size...
  2. Menezo Y, Pluntz L, Chouteau J, Gurgan T, Demirol A, Dalleac A, et al. Zinc concentrations in serum and follicular fluid during ovarian stimulation and expression of Zn2+ transporters in human oocytes and cumulus cells. Reprod Biomed Online. 2011;22:647-52 pubmed publisher
    Serum and follicular fluid zinc concentrations were investigated in patients undergoing assisted reproductive treatment. No correlation was found between zinc and oestradiol concentrations in serum...
  3. Jarkovska K, Kupcova Skalnikova H, Halada P, Hrabakova R, Moos J, Rezabek K, et al. Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization. Mol Hum Reprod. 2011;17:679-92 pubmed publisher
    ..Our aim was to identify candidate proteins in follicular fluid (FF) using various proteomic approaches which may help to identify patients at risk of OHSS...
  4. Montjean D, Entezami F, Lichtblau I, Belloc S, Gurgan T, Menezo Y. Carnitine content in the follicular fluid and expression of the enzymes involved in beta oxidation in oocytes and cumulus cells. J Assist Reprod Genet. 2012;29:1221-5 pubmed publisher
    ..We have tested the total carnitine content (TC) in the follicular fluid of 278 patients (217 non pregnant, 61 pregnant) undergoing IVF...
  5. O Gorman A, Wallace M, Cottell E, Gibney M, McAuliffe F, Wingfield M, et al. Metabolic profiling of human follicular fluid identifies potential biomarkers of oocyte developmental competence. Reproduction. 2013;146:389-95 pubmed publisher
    ..Previous work from our laboratory has demonstrated that the (1)H NMR-based metabolic profile of follicular fluid correlates with oocyte developmental potential...
  6. Fahiminiya S, Reynaud K, Labas V, Batard S, Chastant Maillard S, Gerard N. Steroid hormones content and proteomic analysis of canine follicular fluid during the preovulatory period. Reprod Biol Endocrinol. 2010;8:132 pubmed publisher
    b>Follicular fluid contains substances involved in follicle activity, cell differentiation and oocyte maturation...
  7. Malizia B, Wook Y, Penzias A, Usheva A. The human ovarian follicular fluid level of interleukin-8 is associated with follicular size and patient age. Fertil Steril. 2010;93:537-43 pubmed publisher
    ..University hospital research laboratory and infertility clinic. Women undergoing IVF with oocyte retrieval. Follicular fluid (FF) aspiration, oocyte isolation, FF storage, and experimental studies...
  8. Ledee N, Munaut C, Serazin V, Perrier d Hauterive S, Lombardelli L, Logiodice F, et al. Performance evaluation of microbead and ELISA assays for follicular G-CSF: a non-invasive biomarker of oocyte developmental competence for embryo implantation. J Reprod Immunol. 2010;86:126-32 pubmed publisher
    ..To evaluate the requirements for routine follicular fluid G-CSF quantification, we compared follicular fluid G-CSF measurements made with two multiplexed microbead ..
  9. Altun T, Jindal S, Greenseid K, Shu J, Pal L. Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. J Assist Reprod Genet. 2011;28:245-51 pubmed publisher
    Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles...
  10. Sadeu J, Doedée A, Neal M, Hughes E, Foster W. Neurotrophins (BDNF and NGF) in follicular fluid of women with different infertility diagnoses. Reprod Biomed Online. 2012;24:174-9 pubmed publisher
    ..b>Follicular fluid from the first follicle aspirated from 190 infertile women attending a university-affiliated fertility ..
  11. Naessen T, Kushnir M, Chaika A, Nosenko J, Mogilevkina I, Rockwood A, et al. Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry. Fertil Steril. 2010;94:2228-33 pubmed publisher
    To compare steroid concentrations and steroid product-to-precursor ratios in ovarian follicular fluid (FF) from women with polycystic ovary syndrome (PCOS) and from regularly menstruating women in their early follicular phase, using ..
  12. Ledee N, Gridelet V, Ravet S, Jouan C, Gaspard O, Wenders F, et al. Impact of follicular G-CSF quantification on subsequent embryo transfer decisions: a proof of concept study. Hum Reprod. 2013;28:406-13 pubmed publisher
    Previous experiments have shown that granulocyte colony-stimulating factor (G-CSF), quantified in the follicular fluid (FF) of individual oocytes, correlates with the potential for an ongoing pregnancy of the corresponding fertilized ..
  13. Jarkovska K, Martinkova J, Liskova L, Halada P, Moos J, Rezabek K, et al. Proteome mining of human follicular fluid reveals a crucial role of complement cascade and key biological pathways in women undergoing in vitro fertilization. J Proteome Res. 2010;9:1289-301 pubmed publisher
    ..The primary aim of this study was to search for specific differences in protein composition of human follicular fluid (HFF) and plasma in order to identify proteins that accumulate or are absent in HFF...
  14. Agung B, Piao Y, Fuchimoto D, Senbon S, Onishi A, Otoi T, et al. Effects of oxygen tension and follicle cells on maturation and fertilization of porcine oocytes during in vitro culture in follicular fluid. Theriogenology. 2010;73:893-9 pubmed publisher
    ..follicle cells (FCs) during in vitro maturation of porcine oocytes in only porcine (Sus scrofa domesticus) follicular fluid (pFF), using static and non-static (rotating) culture systems, on the nuclear maturation and subsequent in ..
  15. Estes S, Ye B, Qiu W, Cramer D, Hornstein M, Missmer S. A proteomic analysis of IVF follicular fluid in women <or=32 years old. Fertil Steril. 2009;92:1569-78 pubmed publisher
    To address the lack of predictors of IVF success by using proteomic biometrics. Experimental study of follicular fluid specimens from a prospective cohort of IVF patients. Academic research laboratory and IVF program...
  16. Bijttebier J, Tilleman K, Dhaenens M, Deforce D, Van Soom A, Maes D. Comparative proteome analysis of porcine follicular fluid and serum reveals that excessive alpha(2)-macroglobulin in serum hampers successful expansion of cumulus-oocyte complexes. Proteomics. 2009;9:4554-65 pubmed publisher
    Porcine follicular fluid (pFF) constitutes the micro-environment of the maturing oocyte...
  17. Humaidan P, Westergaard L, Mikkelsen A, Fukuda M, Yding Andersen C. Levels of the epidermal growth factor-like peptide amphiregulin in follicular fluid reflect the mode of triggering ovulation: a comparison between gonadotrophin-releasing hormone agonist and urinary human chorionic gonadotrophin. Fertil Steril. 2011;95:2034-8 pubmed publisher
    To detect differences in follicular fluid (FF) levels of amphiregulin (AR), depending on mode of triggering final oocyte maturation. Prospective randomized trial. Three IVF units...
  18. Cheng X, Chen S, Yu X, Zheng P, Wang H. BMP15 gene is activated during human amniotic fluid stem cell differentiation into oocyte-like cells. DNA Cell Biol. 2012;31:1198-204 pubmed publisher
    ..Together, these results illustrated that the BMP15 could be used as an oogenesis marker to track hAFSCs differentiation into the OLCs. ..
  19. Kim H, Jeong Y, Lee J, Jeong Y, Hossein M, Hyun H, et al. Effects of recombinant relaxin on in vitro maturation of porcine oocytes. J Vet Med Sci. 2010;72:333-7 pubmed
    ..10, and 100 ng/ml) were used in the in vitro maturation (IVM) medium [TCM supplemented with 10% (v/v) porcine follicular fluid, 10 ng/ml of epidermal growth factor, 4 IU/ml of pregnant mare serum gonadotropin, and (only for the first 22 ..
  20. Rodgers R, Irving Rodgers H. Formation of the ovarian follicular antrum and follicular fluid. Biol Reprod. 2010;82:1021-9 pubmed publisher
    The formation of the follicular antrum and follicular fluid has received scant attention from researchers, yet both are important processes in follicular development...
  21. Bossaert P, de Cock H, Leroy J, De Campeneere S, Bols P, Filliers M, et al. Immunohistochemical visualization of insulin receptors in formalin-fixed bovine ovaries post mortem and in granulosa cells collected in vivo. Theriogenology. 2010;73:1210-9 pubmed publisher
    ..classified as healthy or atretic based on the ratio of estrogen and progesterone concentrations in their follicular fluid. Using specialized software, the proportion of pixels displaying a positive staining signal was computed as a ..
  22. Fahiminiya S, Labas V, Dacheux J, Gerard N. Improvement of 2D-PAGE resolution of human, porcine and equine follicular fluid by means of hexapeptide ligand library. Reprod Domest Anim. 2011;46:561-3 pubmed publisher
    The major challenge of follicular fluid proteomic analysis is the presence of high-abundance proteins that originate from plasma...
  23. Nielsen M, Rasmussen I, Kristensen S, Christensen S, Møllgård K, Wreford Andersen E, et al. In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA. Mol Hum Reprod. 2011;17:63-70 pubmed publisher
    ..From the individual aspirated follicles, granulosa cells and the corresponding follicular fluid were isolated in 64 follicles, of which 55 were available for mRNA analysis (24 women)...
  24. Yoo S, Savchev S, Sergott L, Rezai T, Lopez M, Von Wald T, et al. A large network of interconnected signaling pathways in human ovarian follicles is supported by the gene expression activity of the granulosa cells. Reprod Sci. 2011;18:476-84 pubmed publisher
    Human follicular fluid (hFF), as an extra oocyte microenvironment, is essential to the biological processes of oocyte development...
  25. Kushnir M, Naessen T, Wånggren K, Rockwood A, Crockett D, Bergquist J. Protein and steroid profiles in follicular fluid after ovarian hyperstimulation as potential biomarkers of IVF outcome. J Proteome Res. 2012;11:5090-100 pubmed publisher
    ..The goal of our study was to evaluate differences in protein and steroid profiles in ovarian follicular fluid (hFF) samples obtained during oocyte retrieval from women undergoing IVF treatment and to identify ..
  26. Qu F, Wang F, Lu X, Dong M, Sheng J, Lv P, et al. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod. 2010;25:1441-50 pubmed publisher
    ..cells (GCs) of patients with polycystic ovary syndrome (PCOS) was associated with the hyperandrogenism in follicular fluid (FF)...
  27. Bayasula -, Iwase A, Kobayashi H, Goto M, Nakahara T, Nakamura T, et al. A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient. J Assist Reprod Genet. 2013;30:1231-8 pubmed publisher
    Human follicular fluid constitutes the microenvironment of follicles and includes various biological active proteins that can affect follicle growth and oocyte fertilization...
  28. Kushnir M, Naessen T, Kirilovas D, Chaika A, Nosenko J, Mogilevkina I, et al. Steroid profiles in ovarian follicular fluid from regularly menstruating women and women after ovarian stimulation. Clin Chem. 2009;55:519-26 pubmed publisher
    Information on the concentrations of steroids in ovarian follicular fluid (FF) from regularly menstruating (RM) women has been limited because of the absence of methods for the simultaneous quantification of multiple steroids in small ..
  29. Bahar Shany K, Brand H, Sapoznik S, Jacob Hirsch J, Yung Y, Korach J, et al. Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma. Gynecol Oncol. 2014;132:322-7 pubmed publisher
    ..Our aim is to develop such an ex-vivo model based on human fallopian tube (FT) epithelium exposed to human follicular fluid (FF).
  30. Gode F, Gulekli B, Dogan E, Korhan P, Dogan S, Bige O, et al. Influence of follicular fluid GDF9 and BMP15 on embryo quality. Fertil Steril. 2011;95:2274-8 pubmed publisher
    To evaluate the association between follicular fluid levels of propeptide and mature forms of growth differentiation factor (GDF) 9 and bone morphogenetic protein (BMP) 15 with subsequent oocyte and embryo quality...
  31. Desforges Bullet V, Gallo C, Lefebvre C, Pigny P, Dewailly D, Catteau Jonard S. Increased anti-Müllerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization. Fertil Steril. 2010;94:198-204 pubmed publisher
    ..To confirm the increased levels of anti-Müllerian hormone (AMH) in preovulatory follicles from patients with polycystic ovary syndrome (PCOS) and to study the role of other hormones involved in folliculogenesis in this increased secretion...
  32. Anifandis G, Dafopoulos K, Messini C, Chalvatzas N, Liakos N, Pournaras S, et al. Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome. Reprod Biol Endocrinol. 2010;8:91 pubmed publisher
    The aim of the present study was to measure serum and follicular fluid 25-OH vitamin D and glucose levels in women who underwent IVF-ET treatment and to further investigate whether the circulating 25-OH vitamin D and glucose levels ..
  33. Jeppesen J, Nielsen M, Kristensen S, Yding Andersen C. Concentration of activin A and follistatin in follicular fluid from human small antral follicles associated to gene expression of the corresponding granulosa cells. Mol Cell Endocrinol. 2012;356:48-54 pubmed publisher
    The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-..
  34. Ambekar A, Nirujogi R, Srikanth S, Chavan S, Kelkar D, Hinduja I, et al. Proteomic analysis of human follicular fluid: a new perspective towards understanding folliculogenesis. J Proteomics. 2013;87:68-77 pubmed publisher
    Human follicular fluid is a complex body fluid that constitutes the microenvironment of developing follicles in the ovary. Follicular fluid contains a number of proteins that modulate oocyte maturation and ovulation...
  35. Doyle L, Donadeu F. Regulation of the proliferative activity of ovarian surface epithelial cells by follicular fluid. Anim Reprod Sci. 2009;114:443-8 pubmed publisher
    ..b>Follicular fluid but not luteal extracts induced OSE cell proliferation (2.5-fold relative to untreated controls; P<0.0001)...
  36. Hsieh M, Zamah A, Conti M. Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation. Semin Reprod Med. 2009;27:52-61 pubmed publisher
    ..However, attempts to link EGF levels in the follicular fluid with the state of follicle and oocyte maturation have been inconclusive...
  37. La Marca A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio A, et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2010;16:113-30 pubmed publisher
    ..In men AMH is secreted in both the serum and seminal fluid. Its measurement may be useful in clinical evaluation of the infertile male...
  38. Ledee N, Frydman R, Osipova A, Taieb J, Gallot V, Lombardelli L, et al. Levels of follicular G-CSF and interleukin-15 appear as noninvasive biomarkers of subsequent successful birth in modified natural in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2011;95:94-8 pubmed publisher
    ..The modified natural IVF/intracytoplasmic sperm injection (ICSI) cycle was used as an experimental model by measuring levels of cytokines, chemokines, and growth factors in individual follicular fluids (FF)...
  39. Luo W, Gumen A, Haughian J, Wiltbank M. The role of luteinizing hormone in regulating gene expression during selection of a dominant follicle in cattle. Biol Reprod. 2011;84:369-78 pubmed publisher
    ..to measure testosterone and 17beta-estradiol (E(2)) and radioimmunoassay to measure androstenedione (A(4)) in follicular fluid. Concentrations of E(2) were greater in EDF than in ESF of untreated cows near the time of follicle selection ..
  40. Aleyasin A, Hosseini M, Mahdavi A, Safdarian L, Fallahi P, Mohajeri M, et al. Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology. Eur J Obstet Gynecol Reprod Biol. 2011;159:132-7 pubmed publisher
    To assess the correlation between the levels of vitamin D in follicular fluid and serum, and to determine whether the level of 25-hydroxyvitamin D (25OH-D) in follicular fluid of infertile women undergoing assisted reproductive technology ..
  41. Fujimoto V, Bloom M, Huddleston H, Shelley W, Ocque A, Browne R. Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization. Fertil Steril. 2011;96:1357-61 pubmed publisher
    To measure antioxidant enzyme activities and lipid peroxidation levels within follicular fluid (FF) and evaluate correlations with early embryo quality.
  42. de los Santos M, García Láez V, Beltrán Torregrosa D, Horcajadas J, Martinez Conejero J, Esteban F, et al. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. Hum Reprod. 2012;27:1596-605 pubmed publisher
    ..For this purpose, we analyzed the follicular hormonal milieu, the oocyte meiotic spindle, the embryo development and the cumulus cells gene expression (GE) profiles...
  43. Johnson P, Altshul L, Cramer D, Missmer S, Hauser R, Meeker J. Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome. Environ Int. 2012;45:9-14 pubmed publisher
    ..The goal of this study was to investigate the use of serum and follicular fluid as biomarkers of exposure to PBDEs and to explore whether a relationship between PBDE exposure and early ..
  44. Somfai T, Inaba Y, Watanabe S, Geshi M, Nagai T. Follicular fluid supplementation during in vitro maturation promotes sperm penetration in bovine oocytes by enhancing cumulus expansion and increasing mitochondrial activity in oocytes. Reprod Fertil Dev. 2012;24:743-52 pubmed publisher
    The aim of this study was to examine the effects of bovine follicular fluid (bFF) on mitochondrial activity in in vitro-matured (IVM) oocytes and to assess its importance for fertilisation and embryo development...
  45. Valckx S, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, et al. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod. 2012;27:3531-9 pubmed publisher
    Is the metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment (ART) related to serum composition and BMI and is it associated with oocyte and embryo quality?
  46. Ganguly A, Meur S, Ganguly I. Changes in circulatory FSH of Barbari goats following treatment with high molecular weight inhibin isolated from buffalo follicular fluid. Res Vet Sci. 2013;95:374-80 pubmed publisher
    The objective of the present study was to isolate and purify high MW inhibin (? 129 kDa) from buffalo ovarian follicular fluid (buFF) and to investigate its biological activity...
  47. Nimz M, Spitschak M, Schneider F, Fürbass R, Vanselow J. Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids. Domest Anim Endocrinol. 2009;37:45-54 pubmed publisher
    ..were largely down-regulated, whereas (4) progesterone and E2 were found at high concentrations in the follicular fluid. Collectively, our data show that late preovulatory follicles have a transient and unique gene expression ..
  48. Nascimento A, Albornoz M, Che L, Visintin J, Bordignon V. Synergistic effect of porcine follicular fluid and dibutyryl cyclic adenosine monophosphate on development of parthenogenetically activated oocytes from pre-pubertal gilts. Reprod Domest Anim. 2010;45:851-9 pubmed publisher
    This study investigated the effect of porcine follicular fluid (PFF) and dibutyryl cyclic adenosine monophosphate (dbcAMP) during in vitro maturation (IVM) of porcine oocytes on meiotic maturation, fertilization and embryo development, ..
  49. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010;94:1314-9 pubmed publisher
    To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of ..
  50. Meeker J, Missmer S, Altshul L, Vitonis A, Ryan L, Cramer D, et al. Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies. Environ Health. 2009;8:32 pubmed publisher
  51. Wen X, Perrett D, Jones N, Tozer A, Docherty S, Iles R. High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle. Metabolism. 2010;59:1145-55 pubmed publisher
    ..This study investigated the biochemical relationship between human follicular/oocyte maturity and the levels of follicular fluid purines...
  52. Chattopadhayay R, Ganesh A, Samanta J, Jana S, Chakravarty B, Chaudhury K. Effect of follicular fluid oxidative stress on meiotic spindle formation in infertile women with polycystic ovarian syndrome. Gynecol Obstet Invest. 2010;69:197-202 pubmed publisher
    The effect of follicular fluid (FF) oxidative stress (OS) on meiotic spindle (MS) formation in oocytes and subsequent outcome in women with polycystic ovarian syndrome (PCOS) are evaluated in this study.
  53. Iwata H, Tanaka H, Kanke T, Sakaguchi Y, Shibano K, Kuwayama T, et al. Follicle growth and oocyte developmental competence in cows with liver damage. Reprod Domest Anim. 2010;45:888-95 pubmed publisher
    Follicle growth, oocyte quality or oocyte growing environment (follicular fluid) were evaluated in cows with severe liver damage (haemorrhage, telangiectasis, cholangitis and abscess) that were visually diagnosed at the slaughterhouse...
  54. Jana S, K N, Chattopadhyay R, Chakravarty B, Chaudhury K. Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable. Reprod Toxicol. 2010;29:447-51 pubmed publisher
    ..An upper ROS level in follicular fluid (FF) samples of women undergoing IVF beyond which good quality embryo formation is unlikely, is established...
  55. Bersinger N, Wunder D. Adiponectin isoform distribution in serum and in follicular fluid of women undergoing treatment by ICSI. Acta Obstet Gynecol Scand. 2010;89:782-8 pubmed publisher
    ..For the first time, the distribution of these isoforms in serum and follicular fluid (FF) and their usefulness as biological markers for infertility investigations was studied.
  56. Baka S, Zourla K, Kouskouni E, Makrakis E, Demeridou S, Tzanakaki D, et al. Matrix metalloproteinases 2 and 9 and their tissue inhibitors in the follicular fluid of patients with polycystic ovaries undergoing in vitro fertilisation. In Vivo. 2010;24:293-6 pubmed
    ..matrix metalloproteinase (MMP)-2, MMP-9 and their tissue inhibitors (TIMP-2 and TIMP-1, respectively) in the follicular fluid of 39 patients with polycystic ovary syndrome (PCOS) and compare them with the levels found in 56 age- and ..
  57. Pancarci S, Gungor O, Atakisi O, Cigremis Y, Arı U, Bollwein H. Changes in follicular blood flow and nitric oxide levels in follicular fluid during follicular deviation in cows. Anim Reprod Sci. 2011;123:149-56 pubmed publisher
    ..there are dynamic changes in follicular blood flow during follicular deviation and that nitric oxide (NO) in follicular fluid (FF) plays a role in regulation of follicular blood flow...
  58. Pelzer E, Allan J, Cunningham K, Mengersen K, Allan J, Launchbury T, et al. Microbial colonization of follicular fluid: alterations in cytokine expression and adverse assisted reproduction technology outcomes. Hum Reprod. 2011;26:1799-812 pubmed publisher
    Previous studies have measured cytokines expressed within follicular fluid and compared the profiles with the aetiology of infertility and/or successful or unsuccessful assisted reproduction technology (ART) outcomes.
  59. da Silveira J, Veeramachaneni D, Winger Q, Carnevale E, Bouma G. Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: a possible new form of cell communication within the ovarian follicle. Biol Reprod. 2012;86:71 pubmed publisher
    ..1) identify cell-secreted vesicles (microvesicles and exosomes) containing miRNAs and proteins within ovarian follicular fluid and 2) determine if miRNA level differs in exosomes isolated from follicular fluid in young compared to old ..
  60. Krotz S, Carson S, Tomey C, Buster J. Phthalates and bisphenol do not accumulate in human follicular fluid. J Assist Reprod Genet. 2012;29:773-7 pubmed publisher
    To determine if phthalates and bisphenol A accumulate in human follicular fluid after brief exposure to medical plastics during an IVF cycle
  61. Shaaker M, Rahimipour A, Nouri M, Khanaki K, Darabi M, Farzadi L, et al. Fatty acid composition of human follicular fluid phospholipids and fertilization rate in assisted reproductive techniques. Iran Biomed J. 2012;16:162-8 pubmed publisher
    Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women's fertility and the ..
  62. Pelzer E, Allan J, Waterhouse M, Ross T, Beagley K, Knox C. Microorganisms within human follicular fluid: effects on IVF. PLoS ONE. 2013;8:e59062 pubmed publisher
    Our previous study reported microorganisms in human follicular fluid. The objective of this study was to test human follicular fluid for the presence of microorganisms and to correlate these findings with the in vitro fertilization (IVF) ..
  63. Varnagy A, Bene J, Sulyok E, Kovacs G, Bodis J, Melegh B. Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization. Reprod Biol Endocrinol. 2013;11:67 pubmed publisher
    ..Disturbed carnitine metabolism may impair the reproductive potential in IVF and can serve as a biomarker of pregnancy outcome...
  64. Sohel M, Hoelker M, Noferesti S, Salilew Wondim D, Tholen E, Looft C, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS ONE. 2013;8:e78505 pubmed publisher
    ..b>Follicular fluid and cells from individual follicles of cattle were grouped based on Brilliant Cresyl Blue (BCB) staining of ..
  65. Jirsová S, Masata J, Jech L, Zvarova J. Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs. Fertil Steril. 2010;93:1831-6 pubmed publisher
    ..To establish the effect of chlorinated organic compounds on fertility...
  66. Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol. 2009;7:40 pubmed publisher
    ..b>Follicular fluid (FF) is easily available during oocyte pick-up and theorically represents an optimal source on non-invasive ..
  67. Castilla A, Garcia C, Cruz Soto M, Martinez de la Escalera G, Thebault S, Clapp C. Prolactin in ovarian follicular fluid stimulates endothelial cell proliferation. J Vasc Res. 2010;47:45-53 pubmed publisher
    ..proangiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), follicular fluid (FF) contains the hormone prolactin (PRL), which is known to promote angiogenesis in vivo...
  68. Takikawa S, Iwase A, Goto M, Harata T, Umezu T, Nakahara T, et al. Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles. Gynecol Endocrinol. 2010;26:494-9 pubmed publisher
    ..To assess the correlation of intrafollicular insulin, leptin and adiponectin levels with assisted reproductive technologies (ART) outcome...
  69. Sneeringer R, Penzias A, Barrett B, Usheva A. High levels of mineralocorticoids in preovulatory follicular fluid could contribute to oocyte development. Fertil Steril. 2011;95:182-7 pubmed publisher
    To identify aldosterone and precursors in ovarian follicles and to relate levels of mineralocorticoids to previously described renin-angiotensin system follicular fluid content.
  70. Koppan M, Varnagy A, Reglodi D, Brubel R, Nemeth J, Tamas A, et al. Correlation between oocyte number and follicular fluid concentration of pituitary adenylate cyclase-activating polypeptide (PACAP) in women after superovulation treatment. J Mol Neurosci. 2012;48:617-22 pubmed
    ..PACAP) plays an important role in the regulation of several endocrine processes and is present in ovarian follicular fluid (FF)...
  71. Yang X, Wu L, Chura L, Liang X, Lane M, Norman R, et al. Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes. Fertil Steril. 2012;97:1438-43 pubmed publisher
    To determine whether the high lipid content of human follicular fluid influences oocyte maturation.
  72. Fuentes A, Muñoz A, Pommer R, Argüello B, Galleguillos A, Torres A, et al. Decreased anti-Müllerian hormone concentration in follicular fluid of female smokers undergoing artificial reproductive techniques. Chemosphere. 2012;88:403-6 pubmed publisher
    ..Here, we assessed the effect of smoking during the Assisted Reproduction Therapy (ART) on a potential marker of ovarian reserve, anti-müllerian hormone (AMH) in the follicular fluid (FF).
  73. Twigt J, Steegers Theunissen R, Bezstarosti K, Demmers J. Proteomic analysis of the microenvironment of developing oocytes. Proteomics. 2012;12:1463-71 pubmed publisher
    ..of proteolytic peptides and nanoflow reversed-phase LC-MS/MS to identify the (sub)proteome of human follicular fluid (FF)...
  74. Pelzer E, Allan J, Theodoropoulos C, Ross T, Beagley K, Knox C. Hormone-dependent bacterial growth, persistence and biofilm formation--a pilot study investigating human follicular fluid collected during IVF cycles. PLoS ONE. 2012;7:e49965 pubmed publisher
    Human follicular fluid, considered sterile, is aspirated as part of an in vitro fertilization (IVF) cycle...
  75. Renaville B, Bacciu N, Comin A, Motta M, Poli I, Vanini G, et al. Plasma and follicular fluid fatty acid profiles in dairy cows. Reprod Domest Anim. 2010;45:118-21 pubmed publisher
    Composition of follicular fluid to which the preovulatory follicle is exposed may be one of the major factors determining subsequent fertility, as fatty acids are a precursor of hormones involved in dominance, ovulation and atresia ..
  76. Bausenwein J, Serke H, Eberle K, Hirrlinger J, Jogschies P, Hmeidan F, et al. Elevated levels of oxidized low-density lipoprotein and of catalase activity in follicular fluid of obese women. Mol Hum Reprod. 2010;16:117-24 pubmed publisher
    ..dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione reductase (GR) in the serum and follicular fluid were measured...
  77. Li L, Ferin M, Sauer M, Lobo R. Dehydroepiandrosterone in follicular fluid is produced locally, and levels correlate negatively with in vitro fertilization outcomes. Fertil Steril. 2011;95:1830-2 pubmed publisher
    b>Follicular fluid DHEA is produced in part within the ovary. Although follicular DHEA correlated with estradiol and testosterone, it correlated negatively with oocyte and embryo quality.
  78. Salmassi A, Zorn S, Mettler L, Koch K, Jonat W, Schmutzler A. Circulating concentration of stem cell factor in serum of stimulated IVF patients. Reprod Biomed Online. 2011;22:140-7 pubmed publisher
    ..In group 1 (n=74) SCF concentration was assessed in serum and follicular fluid (FF) on the day of follicular puncture (FP) and compared in serum and FF in response to ovarian stimulation ..
  79. Benedict M, Missmer S, Vitonis A, Cramer D, Meeker J. Cotinine concentrations in follicular fluid as a measure of secondhand tobacco smoke exposure in women undergoing in vitro fertilization: inter-matrix comparisons with urine and temporal variability. Chemosphere. 2011;84:110-6 pubmed publisher
    We examined the relationship between cotinine measures in follicular fluid (FF) and urine to inform our exposure assessment strategy for an ongoing epidemiological study of secondhand tobacco smoke (STS) exposure and early pregnancy loss...
  80. Mao J, Whitworth K, Spate L, Walters E, Zhao J, Prather R. Regulation of oocyte mitochondrial DNA copy number by follicular fluid, EGF, and neuregulin 1 during in vitro maturation affects embryo development in pigs. Theriogenology. 2012;78:887-97 pubmed publisher
    ..The present study determined the effects of supplementation of maturation medium with porcine follicular fluid (pFF; 0, 10%, 20%, and 30%) on mtDNA copy number and oocyte maturation in experiment 1; the effects on ..
  81. Borowiecka M, Wojsiat J, Polac I, Radwan M, Radwan P, Zbikowska H. Oxidative stress markers in follicular fluid of women undergoing in vitro fertilization and embryo transfer. Syst Biol Reprod Med. 2012;58:301-5 pubmed publisher
    ..The findings support the idea that increased level of oxidative stress markers in follicular fluid may play an important role in fertility.
  82. Viana J, Dorea M, Siqueira L, Arashiro E, Camargo L, Fernandes C, et al. Occurrence and characteristics of residual follicles formed after transvaginal ultrasound-guided follicle aspiration in cattle. Theriogenology. 2013;79:267-73 pubmed publisher
    ..Ovarian follicles were visualized (transrectal ultrasonography) every 12 h after wave emergence. Follicular fluid samples were collected from the largest follicle and from the ensuing RF and concentrations of estradiol and ..
  83. Bianchi L, Gagliardi A, Campanella G, Landi C, Capaldo A, Carleo A, et al. A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation. J Proteomics. 2013;90:61-76 pubmed publisher
    Human follicular fluid (HFF) has been proven to contain biologically active molecules and proteins that may affect follicle growth and oocyte fertilization...
  84. Nishimoto H, Hamano S, Hill G, Miyamoto A, Tetsuka M. Classification of bovine follicles based on the concentrations of steroids, glucose and lactate in follicular fluid and the status of accompanying follicles. J Reprod Dev. 2009;55:219-24 pubmed
    ..a novel classification procedure based on analysis of the follicular population and glucose concentration in follicular fluid (FF) as an alternative method to classify bovine follicles...
  85. Mashiach R, Amit A, Hasson J, Amzalzg S, Almog B, Ben Yosef D, et al. Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome. Fertil Steril. 2010;93:2299-302 pubmed publisher
    To test whether the follicular fluid (FF) concentration of anti-Mullerian hormone (AMH) is associated with oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome (PCOS) undergoing IVF.
  86. Fujii E, Nakayama M. The measurements of RAGE, VEGF, and AGEs in the plasma and follicular fluid of reproductive women: the influence of aging. Fertil Steril. 2010;94:694-700 pubmed publisher
    To examine the advanced glycation end products (AGEs), the soluble isoform of the receptor for AGEs (sRAGE), and vascular endothelial growth factor (VEGF) concentrations in plasma and follicular fluid (FF) from reproductive-age women.
  87. Ludlow H, Phillips D, Myers M, McLachlan R, de Kretser D, Allan C, et al. A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples. Clin Endocrinol (Oxf). 2009;71:867-73 pubmed publisher
    ..activin B levels in the circulation of healthy participants, IVF patients, pregnant women and in ovarian follicular fluid and seminal plasma...
  88. Grupen C, Armstrong D. Relationship between cumulus cell apoptosis, progesterone production and porcine oocyte developmental competence: temporal effects of follicular fluid during IVM. Reprod Fertil Dev. 2010;22:1100-9 pubmed publisher
    The objective of the present study was to determine the temporal effects of sow follicular fluid (FF) in vitro on cumulus cell viability and function, as well as oocyte nuclear and cytoplasmic maturation...
  89. Becker S, von Otte S, Robenek H, Diedrich K, Nofer J. Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. Biol Reprod. 2011;84:604-12 pubmed publisher
    ..Sphingosine 1-phosphate (S1P), which is associated with follicular fluid high-density lipoprotein (FF-HDL), was previously shown to regulate ovarian angiogenesis...
  90. Wallace M, Cottell E, Gibney M, McAuliffe F, Wingfield M, Brennan L. An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome. Fertil Steril. 2012;97:1078-84.e1-8 pubmed publisher
    To determine whether metabolomic analysis of follicular fluid could prove a useful noninvasive technique for the selection of viable oocytes and embryos.
  91. Dai G, Lu G. Different protein expression patterns associated with polycystic ovary syndrome in human follicular fluid during controlled ovarian hyperstimulation. Reprod Fertil Dev. 2012;24:893-904 pubmed publisher
    ..e. upregulated ?1-antitrypsin, apolipoprotein A-I and transferrin in follicular fluid from PCOS patients than normal controls...
  92. Piñero Sagredo E, Nunes S, de Los Santos M, Celda B, Esteve V. NMR metabolic profile of human follicular fluid. NMR Biomed. 2010;23:485-95 pubmed publisher
    The environment of the oocyte during its in vivo maturation consists of follicular fluid (FF) and is surrounded by granulosa cells...