luteal cells


Summary: PROGESTERONE-producing cells in the CORPUS LUTEUM. The large luteal cells derive from the GRANULOSA CELLS. The small luteal cells derive from the THECA CELLS.

Top Publications

  1. Shibaya M, Deptula K, Korzekwa A, Okuda K, Skarzynski D. Involvement of the cytoskeleton in oxytocin secretion by cultured bovine luteal cells. Biol Reprod. 2005;72:200-5 pubmed
    ..However, isolated bovine luteal cells cultured in a monolayer lose the ability to secrete OT in response to stimulatory substances...
  2. Morelli M, Barberi M, Gambardella A, Borini A, Cecconi S, Coticchio G, et al. Characterization, expression, and functional activity of pituitary adenylate cyclase-activating polypeptide and its receptors in human granulosa-luteal cells. J Clin Endocrinol Metab. 2008;93:4924-32 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are found in the ovary of mammalian species, although nothing is known about the possible role of PACAP and VIP in the human ovary...
  3. Miceli F, Minici F, Tropea A, Catino S, Orlando M, Lamanna G, et al. Effects of nicotine on human luteal cells in vitro: a possible role on reproductive outcome for smoking women. Biol Reprod. 2005;72:628-32 pubmed
    We investigated the effect of nicotine and its methylated metabolite, N-methyl-nicotine (M-nicotine), on human luteal cells by measuring release of progesterone and prostaglandins (PGs) from cultured cells and by testing gene expression ..
  4. Peng J, Tang M, Zhang B, Zhang P, Zhong T, Zong T, et al. Kisspeptin stimulates progesterone secretion via the Erk1/2 mitogen-activated protein kinase signaling pathway in rat luteal cells. Fertil Steril. 2013;99:1436-1443.e1 pubmed publisher
    To observe the effect of kisspeptin on the endocrine function of rat luteal cells.
  5. Jonas K, Chandras C, Abayasekara D, Michael A. Role for prostaglandins in the regulation of type 1 11beta-hydroxysteroid dehydrogenase in human granulosa-lutein cells. Endocrinology. 2006;147:5865-72 pubmed
    ..All three responses to IL-1beta were abolished when cells were cotreated with MA. These findings suggest a role for PGs in the posttranslational regulation of 11betaHSD1 activities in hGL cells...
  6. Okuda K, Korzekwa A, Shibaya M, Murakami S, Nishimura R, Tsubouchi M, et al. Progesterone is a suppressor of apoptosis in bovine luteal cells. Biol Reprod. 2004;71:2065-71 pubmed
    Progesterone is suggested to be a suppressor of apoptosis in bovine luteal cells. Fas antigen (Fas) is a cell surface receptor that triggers apoptosis in sensitive cells...
  7. Bowolaksono A, Nishimura R, Hojo T, Sakumoto R, Acosta T, Okuda K. Anti-apoptotic roles of prostaglandin E2 and F2alpha in bovine luteal steroidogenic cells. Biol Reprod. 2008;79:310-7 pubmed publisher
    ..The overall results suggest that PGE2 and PGF2alpha locally play luteoprotective roles in bovine CL by suppressing apoptosis of LSCs...
  8. Tsai E, Chan T, Chen Y, Hsu S, Chuang C, Lee J. Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells. Fertil Steril. 2008;89:1522-9 pubmed
    To elucidate the role of RU486 in regulating the function of granulosa luteal cells and its possible involvement in ovarian dysfunction.
  9. Tropea A, Tiberi F, Minici F, Orlando M, Gangale M, Romani F, et al. Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells. J Clin Endocrinol Metab. 2007;92:3239-45 pubmed
    ..A possible as-yet-unknown role for ghrelin in modulating luteal function has been suggested because both ghrelin and its receptor (GRLN-R) have been immunohistochemically detected in human corpus luteum...

More Information


  1. May K, Bobe G, Mueller C, Cannon M. Conjugated linoleic acid decreases prostaglandin synthesis in bovine luteal cells in vitro. Mol Reprod Dev. 2011;78:328-36 pubmed publisher
    ..trans-10, cis-12 CLA and cis-9, trans-11 CLA on synthesis of progesterone, PGE(2) , and PGF(2?) , in bovine luteal cells was determined in this study. Luteal cells from three cows were cultured in medium containing 0 or 0...
  2. Chen D, Davis J. Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells. Mol Cell Endocrinol. 2003;200:141-54 pubmed
    ..undergo rapid tyrosine phosphorylation and internalization upon ligand binding in ovarian cells, including luteal cells. However, little is known about the post-receptor signaling events induced by EGF that lead to the ..
  3. Lee S, Acosta T, Yoshioka S, Okuda K. Prostaglandin F(2alpha) regulates the nitric oxide generating system in bovine luteal endothelial cells. J Reprod Dev. 2009;55:418-24 pubmed
    ..Stimulation of the NO generating system and NOS activity by PGF may result in increasing local NO production followed by luteolysis...
  4. Nishimura R, Shibaya M, Skarzynski D, Okuda K. Progesterone stimulation by LH involves the phospholipase-C pathway in bovine luteal cells. J Reprod Dev. 2004;50:257-61 pubmed
    Luteinizing hormone (LH)-stimulated steroidogenesis in luteal cells is known to be mediated through the activation of cyclic AMP (cAMP)-dependent protein kinase, and to be also modulated by calcium-dependent mechanisms...
  5. Goyeneche A, Harmon J, Telleria C. Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis. Reproduction. 2006;131:103-11 pubmed
    ..for producing progesterone followed by its structural involution, which is associated with apoptosis of the luteal cells. An in vitro experimental approach is needed to study the molecular mechanisms underlying hormonal regulation ..
  6. Kaivo Oja N, Bondestam J, Kämäräinen M, Koskimies J, Vitt U, Cranfield M, et al. Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells. J Clin Endocrinol Metab. 2003;88:755-62 pubmed
  7. Fan H, Liu Z, Cahill N, Richards J. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Mol Endocrinol. 2008;22:2128-40 pubmed publisher
    ..and luteal cell steroidogenesis in Ptenfl/fl;Cyp19-Cre mice was similar to controls, viable nonsteroidogenic luteal cells escaped structural luteolysis...
  8. Połeć A, Tanbo T, Fedorcsak P. Cellular interaction regulates interleukin-8 secretion by granulosa-lutein cells and monocytes/macrophages. Am J Reprod Immunol. 2009;61:85-94 pubmed publisher
    ..In this study, we examined the secretion of the neutrophil chemoattractant interleukin (IL)-8 by ovarian GL cells and the role of monocytes in IL-8 secretion...
  9. Dickinson R, Stewart A, Myers M, Millar R, Duncan W. Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis. Endocrinology. 2009;150:2873-81 pubmed publisher
    ..Overall, these results imply expression of LHR splice variants is regulated in the human CL. Furthermore, during functional luteolysis a truncated variant could modulate the cell surface expression and activity of full-length LHR...
  10. Kurusu S, Sakaguchi S, Kawaminami M. Regulation of luteal prostaglandin F(2 alpha) production and its relevance to cell death: an in vitro study using rat dispersed luteal cells. Prostaglandins Other Lipid Mediat. 2007;83:250-6 pubmed
    We investigated the mechanism by which rat luteal cells produce prostaglandin F(2 alpha) (PGF(2 alpha)) and its relevance to cell death in vitro...
  11. Townson D, Putnam A, Sullivan B, Guo L, Irving Rodgers H. Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: an intrinsic mechanism of resistance to apoptosis?. Histol Histopathol. 2010;25:889-900 pubmed publisher
    ..05, n = 3-5 CL/stage), suggesting CK8/18 filament expression diminishes over time, as luteal cells become more susceptible to apoptosis...
  12. Tsai S, Wu M, Chuang P, Chen H. Distinct regulation of gene expression by prostaglandin F(2alpha) (PGF(2alpha)) is associated with PGF(2alpha) resistance or susceptibility in human granulosa-luteal cells. Mol Hum Reprod. 2001;7:415-23 pubmed
    ..We conclude that, via distinct gene regulation at different stages of differentiation, human GLC may become resistant or susceptible to PGF(2alpha)-induced luteolysis...
  13. Liu J, Vänttinen T, Hyden Granskog C, Voutilainen R. Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells. Mol Hum Reprod. 2002;8:992-7 pubmed
    ..types in the ovary, while it is known that gonadotrophins induce follistatin gene expression in human granulosa-luteal cells. In this study, we investigated the expression of FLRG mRNA in granulosa-luteal cells of preovulatory follicles ..
  14. Wu L, Chen J, Sheu S, Huang C, Kuo Y, Chiu C, et al. Isocupressic acid blocks progesterone production from bovine luteal cells. Am J Chin Med. 2002;30:533-41 pubmed
    ..Thawed bovine luteal cells (1 x 10(5) cells/ml/well) in M199 medium were cultured in 24-well culture plates at 37 degrees C in a 5% CO2 ..
  15. Siawrys G, Smolinska N. In vitro effects of luteinizing hormone, progesterone and oestradiol-17? on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy. J Physiol Pharmacol. 2013;64:513-20 pubmed
    ..porcine corpus luteum, but the regulatory mechanism of leptin mRNA expression and leptin secretion in porcine luteal cells remains unexplained...
  16. Yang H, Bhat G, Wadley R, Wright K, Chung B, Whittaker J, et al. Gonadotropin-releasing hormone-agonist inhibits synthesis of nitric oxide and steroidogenesis by luteal cells in the pregnant rat. Biol Reprod. 2003;68:2222-31 pubmed
    ..To investigate the mechanism(s) by which progesterone secretion is suppressed and apoptosis is induced in the luteal cells, we studied nitric oxide (NO) as a messenger molecule for GnRH action...
  17. Usuki S, Kotani E. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells from rat ovary. Gynecol Endocrinol. 2001;15:184-91 pubmed
    ..the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells from rat ovary...
  18. Korzekwa A, Jaroszewski J, Bogacki M, Deptula K, Maslanka T, Acosta T, et al. Effects of prostaglandin F(2alpha) and nitric oxide on the secretory function of bovine luteal cells. J Reprod Dev. 2004;50:411-7 pubmed
    ..F(2alpha) (PGF (2alpha)) and nitric oxide (NO) on production of steroids and PGs by culturing bovine luteal cells obtained from ovaries on days 8-12 of the estrous cycle with a nitric oxide (NO) donor (Spermine NONOate), and ..
  19. Petroff M, Petroff B, Pate J. Mechanisms of cytokine-induced death of cultured bovine luteal cells. Reproduction. 2001;121:753-60 pubmed
    Tumour necrosis factor alpha (TNF-alpha) and gamma-interferon (IFN-gamma) are cytotoxic to bovine luteal cells in vitro and may contribute to cell death during luteolysis in vivo...
  20. Lee S, Acosta T, Nakagawa Y, Okuda K. Role of nitric oxide in the regulation of superoxide dismutase and prostaglandin F(2alpha) production in bovine luteal endothelial cells. J Reprod Dev. 2010;56:454-9 pubmed
  21. Sakumoto R, Komatsu T, Kasuya E, Saito T, Okuda K. Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle. Domest Anim Endocrinol. 2006;31:246-57 pubmed
    ..cytokines on progesterone (P(4)), estradiol-17beta (E(2)) and prostaglandin (PG) F2alpha secretion by cultured luteal cells were investigated. IL-4 and IL-6 mRNAs were detected in the CL at all luteal stages...
  22. Rice S, Mason H, Whitehead S. Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. J Steroid Biochem Mol Biol. 2006;101:216-25 pubmed
  23. Tatsukawa Y, Bowolaksono A, Nishimura R, Komiyama J, Acosta T, Okuda K. Possible roles of intracellular cyclic AMP, protein kinase C and calcium ion in the apoptotic signaling pathway in bovine luteal cells. J Reprod Dev. 2006;52:517-22 pubmed
    Structural luteolysis occurs by apoptosis of luteal cells. The present study examined the effects of activators of well-characterized second messengers on Fas and caspase-3 mRNA expression and on P4 production in luteal cells in order to ..
  24. Hashii K, Fujiwara H, Yoshioka S, Kataoka N, Yamada S, Hirano T, et al. Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and non-pregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation. Hum Reprod. 1998;13:2738-44 pubmed
    Human luteal cells have been reported to express human leukocyte antigen-DR and lymphocyte functional antigen-3 on the cell surface, suggesting physiological interaction between luteal cells and T-lymphocytes through the menstrual cycle ..
  25. Gaytan F, Bellido C, Morales C, Sanchez Criado J. Luteolytic effect of prolactin is dependent on the degree of differentiation of luteal cells in the rat. Biol Reprod. 2001;65:433-41 pubmed
    ..These results indicate that PRL does not induce apoptosis in the CLP before Day 5 postpartum and strongly suggest that the proapoptotic effect of PRL is dependent on the degree of differentiation of luteal cells.
  26. Tropea A, Miceli F, Minici F, Tiberi F, Orlando M, Gangale M, et al. Regulation of vascular endothelial growth factor synthesis and release by human luteal cells in vitro. J Clin Endocrinol Metab. 2006;91:2303-9 pubmed
    Vascular endothelial growth factor (VEGF) is essential for normal luteal development and function, but little is still known about the regulation of its production by human midluteal phase luteal cells.
  27. Cannon M, Petroff M, Pate J. Effects of prostaglandin F2alpha and progesterone on the ability of bovine luteal cells to stimulate T lymphocyte proliferation. Biol Reprod. 2003;69:695-700 pubmed
    Bovine luteal cells express class I and II major histocompatibility complex molecules and stimulate T lymphocyte proliferation in vitro...
  28. Thurston L, Chin E, Jonas K, Bujalska I, Stewart P, Abayasekara D, et al. Expression of 11beta-hydroxysteroid dehydrogenase (11betaHSD) proteins in luteinizing human granulosa-lutein cells. J Endocrinol. 2003;178:127-35 pubmed
    ..9% and 34.2%; P<0.05) over this same period. Changes in enzyme expression and activity were unaffected by the suppression of ovarian steroid synthesis...
  29. Salli U, Saito N, Stormshak F. Spatiotemporal interactions of myristoylated alanine-rich C kinase substrate (MARCKS) protein with the actin cytoskeleton and exocytosis of oxytocin upon prostaglandin F2alpha stimulation of bovine luteal cells. Biol Reprod. 2003;69:2053-8 pubmed
    ..In experiment 2, luteal cells were transfected with one of the three MARCKS-GFP constructs...
  30. Wu Y, Wiltbank M. Differential regulation of prostaglandin endoperoxide synthase-2 transcription in ovine granulosa and large luteal cells. Prostaglandins Other Lipid Mediat. 2001;65:103-16 pubmed
    ..regulation of prostaglandin synthase-2 (PGS-2) mRNA and PGS-2 promoter in ovine granulosa cells and large luteal cells. In granulosa cells, PGS-2 mRNA was induced by forskolin (PKA activator) but not by phorbol didecanoate (PDD; ..
  31. Park D, Cho T, Kim M, Kim Y, Min C, Hwang K. ATP-induced apoptosis of human granulosa luteal cells cultured in vitro. Fertil Steril. 2003;80:993-1002 pubmed
    ..To investigate the role of extracellular adenosine triphosphatase (ATP) as an inducer of apoptotic cell death in human granulosa cells and to elucidate its underlying mechanism...
  32. Liu J, Kuulasmaa T, Kosma V, Butzow R, Vänttinen T, Hyden Granskog C, et al. Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells. J Clin Endocrinol Metab. 2003;88:5002-8 pubmed
    ..pattern of betaglycan gene in normal ovaries and sex cord-stromal tumors and in cultured human granulosa-luteal cells from women undergoing in vitro fertilization...
  33. Sekar N, Veldhuis J. Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells. Am J Physiol Endocrinol Metab. 2004;287:E128-35 pubmed
    ..low-density lipoprotein (LDL) receptor (LDLR) promoter supra-additively in primary cultures of granulosa-luteal cells. The mechanistic basis of this bihormonal interaction is unknown...
  34. Sen A, Wright M, Inskeep E, Flores J. Participation of specific PKC isozymes in the inhibitory effect of ET-1 on progesterone accumulation in cells isolated from early- and mid-phase corpora lutea. Domest Anim Endocrinol. 2006;31:284-99 pubmed
    ..Inhibition of P(4) by ET-1 in the early CL may be mediated via conventional PKC isozymes...
  35. Romani F, Tropea A, Scarinci E, Dello Russo C, Lisi L, Catino S, et al. Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013;31:170-80 pubmed publisher
    ..In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2?, PGE2 and vascular endothelial growth ..
  36. Torres A, Batista M, Diniz P, Mateus L, Lopes da Costa L. Embryo-luteal cells co-culture: an in vitro model to evaluate steroidogenic and prostanoid bovine early embryo-maternal interactions. In Vitro Cell Dev Biol Anim. 2013;49:134-46 pubmed publisher
    ..the in vitro steroidogenic (P(4)) and prostanoid (PGE(2) and PGF(2?)) interactions between bovine embryos and luteal cells (LC) were evaluated. In two experiments, embryos (n = 1...
  37. Taketani T, Tamura H, Takasaki A, Lee L, Kizuka F, Tamura I, et al. Protective role of melatonin in progesterone production by human luteal cells. J Pineal Res. 2011;51:207-13 pubmed publisher
    ..In conclusion, melatonin protects granulosa cells undergoing luteinization from ROS in the follicle and contributes to luteinization for progesterone production during ovulation...
  38. Zhang Z, Yin D, Wang Z. Contribution of hypoxia-inducible factor-1? to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells. Anim Sci J. 2011;82:244-50 pubmed publisher
    ..activation contributes to the increased expression of VEGF gene in response to hypoxia in the bovine developing luteal cells (LCs)...
  39. Park E, Shin J, Seo Y, Kim D, Hong S, Park W, et al. Gonadotropin-releasing hormone-agonist induces apoptosis of human granulosa-luteal cells via caspase-8, -9 and -3, and poly-(ADP-ribose)-polymerase cleavage. Biosci Trends. 2011;5:120-8 pubmed
    ..PARP) cleavage are involved in the mechanism by which GnRH-Ag induces apoptosis in human granulosa-luteal cells. The prospective study was conducted in the research institute and clinical fertility center of university ..
  40. Lee J, McCracken J, Stanley J, Nithy T, Banu S, Arosh J. Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep. Biol Reprod. 2012;87:97 pubmed publisher
  41. Hou X, Arvisais E, Davis J. Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase. Endocrinology. 2010;151:2846-57 pubmed publisher
    LH stimulates the production of cAMP in luteal cells, which leads to the production of progesterone, a hormone critical for the maintenance of pregnancy...
  42. Thurston L, Abayasekara D, Michael A. 11beta-Hydroxysteroid dehydrogenase expression and activities in bovine granulosa cells and corpora lutea implicate corticosteroids in bovine ovarian physiology. J Endocrinol. 2007;193:299-310 pubmed 11-ketosteroid reductase and 11beta-dehydrogenase (11beta-DH) activities in bovine follicular granulosa and luteal cells. Granulosa cells were isolated from follicles of < 4, 4-8, > 8 and > 12 mm in diameter in either the ..
  43. Korzekwa A, Okuda K, Woclawek Potocka I, Murakami S, Skarzynski D. Nitric oxide induces apoptosis in bovine luteal cells. J Reprod Dev. 2006;52:353-61 pubmed, the molecular mechanisms of NO action during structural luteolysis were studied in cultured bovine luteal cells (Days 15-17 of the estrous cycle)...
  44. Lacey M, Bohday J, Fonseka S, Ullah A, Whitehead S. Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells. J Steroid Biochem Mol Biol. 2005;96:279-86 pubmed
    ..We have also shown for the first time that phytoestrogens do not act by inhibiting the cellular concentration of 3beta-HSD and aromatase even though exposure time would have allowed for changes in gene expression...
  45. Choudhary E, Sen A, Inskeep E, Flores J. Developmental sensitivity of the bovine corpus luteum to prostaglandin F2alpha (PGF2alpha) and endothelin-1 (ET-1): is ET-1 a mediator of the luteolytic actions of PGF2alpha or a tonic inhibitor of progesterone secretion?. Biol Reprod. 2005;72:633-42 pubmed
    We examined the responsiveness of large luteal cells (LLC), small luteal cells (SLC), and endothelial cells of the Day 4 and Day 10 bovine corpus luteum (CL) to prostaglandin (PG) F2alpha and endothelin (ET)-1...
  46. Komatsu K, Manabe N, Kiso M, Shimabe M, Miyamoto H. Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries. Mol Reprod Dev. 2003;65:345-52 pubmed
    ..Apoptosis was induced in primary cultured luteal cells, when they were pretreated with TNF-alpha and IFN-gamma and then incubated with TNF-alpha, IFN-gamma, and mouse ..
  47. Väänänen J, Tong B, Väänänen C, Chan I, Yuen B, Leung P. Interaction of prostaglandin F(2alpha) and prostaglandin E(2) on progesterone production in human granulosa-luteal cells. Biol Signals Recept. 2001;10:380-8 pubmed
    ..PGF(2alpha)), prostaglandin-E(2) (PGE(2)) and their interactions on progesterone production in human granulosa-luteal cells (GLCs)...
  48. Tai C, Kang S, Choi K, Tzeng C, Leung P. Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha. J Clin Endocrinol Metab. 2001;86:3237-42 pubmed
    The presence of P2U purinoceptor in human granulosa-luteal cells (hGLCs) indicates a potential role of ATP in regulating ovarian function. In this study an inhibitory effect of ATP on hCG-induced cAMP production was observed...
  49. Zhang Z, Yu D, Yin D, Wang Z. Activation of PI3K/mTOR signaling pathway contributes to induction of vascular endothelial growth factor by hCG in bovine developing luteal cells. Anim Reprod Sci. 2011;125:42-8 pubmed publisher
    ..To our knowledge this will provide a new insight into the important mechanism of hCG/LH-induced VEGF-dependent angiogenesis in the bovine ovary...
  50. Kaivo Oja N, Mottershead D, Mazerbourg S, Myllymaa S, Duprat S, Gilchrist R, et al. Adenoviral gene transfer allows Smad-responsive gene promoter analyses and delineation of type I receptor usage of transforming growth factor-beta family ligands in cultured human granulosa luteal cells. J Clin Endocrinol Metab. 2005;90:271-8 pubmed
  51. Cheng C, Yeung C, Chow B, Leung P. Characterization of a new upstream GnRH receptor promoter in human ovarian granulosa-luteal cells. Mol Endocrinol. 2002;16:1552-64 pubmed
    ..Here we report the characterization of a new upstream promoter for the GnRHR gene in human granulosa-luteal cells. Using progressive deletion analysis, a region between nucleotide -1300 and -1018 (relative to the translation ..
  52. Huang Y, Li W, Zhao X, Ding L, Yu G, Dong F, et al. Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology. 2013;80:41-9 pubmed publisher
    ..In this study, primary and transfected luteal cells were used to investigate the effects of SW on progesterone secretion and cell viability and the mechanisms ..
  53. Shrestha K, Onasanya A, Eisenberg I, Wigoda N, Yagel S, Yalu R, et al. miR-210 and GPD1L regulate EDN2 in primary and immortalized human granulosa-lutein cells. Reproduction. 2018;155:197-205 pubmed publisher
    ..This study highlights the novel regulatory roles of miR-210 and its gene target, GPD1L, in hypoxia and cAMP-induced EDN2 by human granulosa-lutein cells. ..
  54. Masso R, Saag A, Arend A, Masso M, Selstam G. Alpha B-crystallin in corpora lutea of pseudopregnant rat. Medicina (Kaunas). 2003;39:965-74 pubmed
    ..At light microscopical level alphaB-crystallin labeling decreased during CL life span in the central area of luteal cells cytoplasm and increased in the peri-plasmalemmal area...
  55. Engmann L, Romak J, Nulsen J, Benadiva C, Peluso J. In vitro viability and secretory capacity of human luteinized granulosa cells after gonadotropin-releasing hormone agonist trigger of oocyte maturation. Fertil Steril. 2011;96:198-202 pubmed publisher
    ..Serum E(2) levels were lower at 5 and 9 days after GnRH agonist compared with hCG trigger. The granulosa/luteal cells obtained on the day of oocyte retrieval after GnRH agonist trigger are still viable and have the capacity to ..
  56. Gomes F, Navarro P, de Abreu L, Ferriani R, Dos Reis R, de Moura M. Effect of peritoneal fluid from patients with minimal/mild endometriosis on progesterone release by human granulosa-lutein cells obtained from infertile patients without endometriosis: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2008;138:60-5 pubmed publisher