corpus luteum

Summary

Summary: The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.

Top Publications

  1. Hojo T, ODA A, Lee S, Acosta T, Okuda K. Effects of tumor necrosis factor ? and Interferon ? on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum. J Reprod Dev. 2010;56:515-9 pubmed
    The corpus luteum (CL) is mainly composed of luteal steroidogenic cells (LSCs) and luteal endothelial cells (LECs). Cell death of LSCs and LECs is essential for structural luteolysis...
  2. Lee S, Acosta T, Nakagawa Y, Okuda K. Role of nitric oxide in the regulation of superoxide dismutase and prostaglandin F(2alpha) production in bovine luteal endothelial cells. J Reprod Dev. 2010;56:454-9 pubmed
  3. Ferreira Dias G, Costa A, Mateus L, Korzekwa A, Galvao A, Redmer D, et al. Nitric oxide stimulates progesterone and prostaglandin E2 secretion as well as angiogenic activity in the equine corpus luteum. Domest Anim Endocrinol. 2011;40:1-9 pubmed publisher
    ..Furthermore, in mares, NO may play a role in CL growth during early luteal development, when vascular development is more intense...
  4. Ma T, Jiang H, Gao Y, Zhao Y, Dai L, Xiong Q, et al. Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. J Appl Genet. 2011;52:481-6 pubmed publisher
    ..Recent studies indicated that miRNAs are mechanistically involved in the regulation of the mammalian corpus luteum (CL)...
  5. Stouffer R, Bishop C, Bogan R, Xu F, Hennebold J. Endocrine and local control of the primate corpus luteum. Reprod Biol. 2013;13:259-71 pubmed publisher
    The primate corpus luteum is a transient endocrine gland that differentiates from the ovulatory follicle midway through the ovarian (menstrual) cycle...
  6. Luo W, Diaz F, Wiltbank M. Induction of mRNA for chemokines and chemokine receptors by prostaglandin F2? is dependent upon stage of the porcine corpus luteum and intraluteal progesterone. Endocrinology. 2011;152:2797-805 pubmed publisher
    ..PG) F(2?) increases expression of genes related to recruitment of leukocytes in mature but not early corpus luteum (CL) and that insensitivity to PGF(2?) action in early CL is dependent on high intraluteal progesterone (P4) ..
  7. Nitta A, Shirasuna K, Haneda S, Matsui M, Shimizu T, Matsuyama S, et al. Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow. Reproduction. 2011;142:879-92 pubmed publisher
    The corpus luteum (CL), which secretes large amounts of progesterone and is thus essential for establishing pregnancy, contains various types of immune cells that may play essential roles in CL function by generating immune responses...
  8. Vecchio D, Neglia G, Gasparrini B, Russo M, Pacelli C, Prandi A, et al. Corpus luteum development and function and relationship to pregnancy during the breeding season in the Mediterranean buffalo. Theriogenology. 2012;77:1811-5 pubmed publisher
    The aim of this study was to ascertain corpus luteum (CL) development and function in buffaloes synchronized and mated by artificial insemination (AI) during the breeding season. Italian Mediterranean buffalo cows (n = 43) at 86.5 ± 2...
  9. Shirasuna K, Nitta A, Sineenard J, Shimizu T, Bollwein H, Miyamoto A. Vascular and immune regulation of corpus luteum development, maintenance, and regression in the cow. Domest Anim Endocrinol. 2012;43:198-211 pubmed publisher
    The bovine corpus luteum (CL) is a unique, transient organ with well-coordinated mechanisms by which its development, maintenance, and regression are effectively controlled...

More Information

Publications89

  1. Di Francesco S, Neglia G, Vecchio D, Rossi P, Russo M, Zicarelli L, et al. Influence of season on corpus luteum structure and function and AI outcome in the Italian Mediterranean buffalo (Bubalus bubalis). Theriogenology. 2012;78:1839-45 pubmed publisher
    The aim was to ascertain whether relationships between corpus luteum (CL) vascularization, CL function, and pregnancy outcome in AI in buffaloes were consistent across the breeding season and transition period to the nonbreeding season ..
  2. Galvao A, Ferreira Dias G, Skarzynski D. Cytokines and angiogenesis in the corpus luteum. Mediators Inflamm. 2013;2013:420186 pubmed publisher
    ..Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the ..
  3. Berisha B, Schilffarth S, Kenngott R, Sinowatz F, Meyer H, Schams D. Expression of lymphangiogenic vascular endothelial growth factor family members in bovine corpus luteum. Anat Histol Embryol. 2013;42:292-303 pubmed publisher
    ..In conclusion, our results lead to the assumption that lymphangiogenic factors are produced and regulated in CL and may be involved in mechanisms regulating CL function, especially during pregnancy...
  4. Chen S, Chen R, Shieh J, Chou C, Lin C, Lu H, et al. Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome. J Clin Endocrinol Metab. 2010;95:3982-92 pubmed publisher
    The corpus luteum is a dynamic endocrine structure with periodic development and regression during menstrual cycles. Its lifespan can be prolonged by human chorionic gonadotropin (hCG)...
  5. Kowalewski M, Meyer A, Hoffmann B, Aslan S, Boos A. Expression and functional implications of peroxisome proliferator-activated receptor gamma (PPAR?) in canine reproductive tissues during normal pregnancy and parturition and at antiprogestin induced abortion. Theriogenology. 2011;75:877-86 pubmed publisher
    ..Treatment with Aglepristone led to downregulation of PPAR? in either compartment, implying the functional interrelationship with progesterone receptor...
  6. Sboros V, Averkiou M, Lampaskis M, Thomas D, Silva N, Strouthos C, et al. Imaging of the ovine corpus luteum microcirculation with contrast ultrasound. Ultrasound Med Biol. 2011;37:59-68 pubmed publisher
    Ultrasound contrast agents have been the subject of microvascular imaging research. The sheep corpus luteum (CL) is a microvascular tissue that provides a natural angiogenic and antiangiogenic process, which changes during the luteal ..
  7. Jiemtaweeboon S, Shirasuna K, Nitta A, Kobayashi A, Schuberth H, Shimizu T, et al. Evidence that polymorphonuclear neutrophils infiltrate into the developing corpus luteum and promote angiogenesis with interleukin-8 in the cow. Reprod Biol Endocrinol. 2011;9:79 pubmed publisher
    After ovulation in the cow, the corpus luteum (CL) rapidly develops within a few days with angiogenesis and progesterone production. CL formation resembles an inflammatory response due to the influx of immune cells...
  8. Rekawiecki R, Rutkowska J, Kotwica J. Identification of optimal housekeeping genes for examination of gene expression in bovine corpus luteum. Reprod Biol. 2012;12:362-7 pubmed publisher
    ..The aim of the study was to identify optimal housekeeping genes in the corpus luteum obtained from cyclic or pregnant cows...
  9. Galv o A, Skarzynski D, Sz stek A, Silva E, Tramontano A, Mollo A, et al. Cytokines tumor necrosis factor-? and interferon-? participate in modulation of the equine corpus luteum as autocrine and paracrine factors. J Reprod Immunol. 2012;93:28-37 pubmed publisher
    Knowledge on the regulation of corpus luteum (CL) function in the mare is scarce...
  10. Diaz F, Luo W, Wiltbank M. Effect of decreasing intraluteal progesterone on sensitivity of the early porcine corpus luteum to the luteolytic actions of prostaglandin F2alpha. Biol Reprod. 2011;84:26-33 pubmed publisher
    Prostaglandin F2alpha (PGF) causes luteolysis of the pig corpus luteum (CL) only after Day 12 of the estrous cycle. Recent evidence indicates that progesterone (P4) may protect the CL from cell death...
  11. Nio Kobayashi J, Narayanan R, Giakoumelou S, Boswell L, Hogg K, Duncan W. Expression and localization of inhibitor of differentiation (ID) proteins during tissue and vascular remodelling in the human corpus luteum. Mol Hum Reprod. 2013;19:82-92 pubmed publisher
    ..TGF-?) superfamily are likely to have major roles in the regulation of tissue and vascular remodelling in the corpus luteum (CL)...
  12. Magata F, Shirasuna K, Strüve K, Herzog K, Shimizu T, Bollwein H, et al. Gene expressions in the persistent corpus luteum of postpartum dairy cows: distinct profiles from the corpora lutea of the estrous cycle and pregnancy. J Reprod Dev. 2012;58:445-52 pubmed
    Persistence of the corpus luteum (CL) in cattle usually occurs during the puerperium and is associated with interference of prostaglandin (PG) F(2?) release from the uterus...
  13. Gur S, Turk G, Demirci E, Yuce A, Sonmez M, Ozer S, et al. Effect of pregnancy and foetal number on diameter of corpus luteum, maternal progesterone concentration and oxidant/antioxidant balance in ewes. Reprod Domest Anim. 2011;46:289-95 pubmed publisher
    The aim of this study was to determine the changes in diameter of corpus luteum (CL), maternal progesterone (P) concentration, lipid peroxidation and non-enzymatic antioxidant levels along with enzymatic antioxidant activities in ..
  14. Herzog K, Str ve K, Kastelic J, Piechotta M, Ulbrich S, Pfarrer C, et al. Escherichia coli lipopolysaccharide administration transiently suppresses luteal structure and function in diestrous cows. Reproduction. 2012;144:467-76 pubmed publisher
    ..05) at 1 h after LPS. At 12 h after treatment, levels of mRNA encoding Caspase-3 in biopsies of the corpus luteum (CL) were increased (P?0.05), whereas those encoding StAR were decreased (P?0...
  15. Endo N, Nagai K, Tanaka T, Kamomae H. Comparison between lactating and non-lactating dairy cows on follicular growth and corpus luteum development, and endocrine patterns of ovarian steroids and luteinizing hormone in the estrous cycles. Anim Reprod Sci. 2012;134:112-8 pubmed publisher
    The dynamics of ovarian follicle, corpus luteum (CL), and peripheral plasma ovarian steroids were compared between lactating and non-lactating cows, and a possible association of pulsatile luteinizing hormone (LH) secretion with the ..
  16. Suresh P, Medhamurthy R. Studies on reactivation of regressing bonnet monkey corpus luteum on day 1 of menses: a pilot study. Syst Biol Reprod Med. 2013;59:1-4 pubmed publisher
    Studies on functional characteristics of the regressing primate corpus luteum (CL) to luteotrophic stimulus on day 1 of the non-fertile menstrual cycle are scarce...
  17. Kowalczyk Zieba I, Boruszewska D, Saulnier Blache J, Lopes da Costa L, Jankowska K, Skarzynski D, et al. Lysophosphatidic acid action in the bovine corpus luteum -an in vitro study. J Reprod Dev. 2012;58:661-71 pubmed
    ..The stimulatory effect of LPA on P4 synthesis via 3?HSD stimulation and LPA-dependent stimulation of IFN? action on OAS1 and ISG15 expression suggest that LPA is an additional auxiliary luteosupportive factor in steroidogenic cells...
  18. Korzekwa A, Bah M, Kurzynowski A, Lukasik K, Groblewska A, Skarzynski D. Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. Reproduction. 2010;140:767-76 pubmed publisher
    ..The aim of this study was to examine the role of LTs in corpus luteum (CL) function during both the estrous cycle and early pregnancy in vivo...
  19. Galvao A, Ramilo D, Skarzynski D, Lukasik K, Tramontano A, Mollo A, et al. Is FAS/Fas ligand system involved in equine corpus luteum functional regression?. Biol Reprod. 2010;83:901-8 pubmed publisher
    ..of the present work was to determine (i) the presence of the cytokine FASL and its receptor FAS in the mare's corpus luteum (CL) throughout the luteal phase, as well as (ii) the influence of FASL alone, or together with the cytokines ..
  20. Slough T, Rispoli L, Carnevale E, Niswender G, Bruemmer J. Temporal gene expression in equine corpora lutea based on serial biopsies in vivo. J Anim Sci. 2011;89:389-96 pubmed publisher
    A biopsy procedure was developed to enable repeated sampling of a single equine corpus luteum (CL) over the course of an estrous cycle...
  21. Galv o A, Sz stek A, Skarzynski D, Ferreira Dias G. Role of tumor necrosis factor-?, interferon-? and Fas-ligand on in vitro nitric oxide activity in the corpus luteum. Cytokine. 2013;64:18-21 pubmed publisher
    Normal reproductive function involves the expression of inflammatory mediators. Regarding the corpus luteum (CL), cytokines promote the cross-talk between immune, vascular and steroidogenic cells, among others...
  22. Herzog K, Voss C, Kastelic J, Beindorff N, Paul V, Niemann H, et al. Luteal blood flow increases during the first three weeks of pregnancy in lactating dairy cows. Theriogenology. 2011;75:549-54 pubmed publisher
    ..4 ± 0.2, and ? 6 wk postpartum at the start of the study, were used. The corpus luteum (CL) was examined with transrectal color Doppler ultrasonography (10...
  23. Duong H, Piotrowska Tomala K, Acosta T, Bah M, Sinderewicz E, Majewska M, et al. Effects of cortisol on pregnancy rate and corpus luteum function in heifers: an in vivo study. J Reprod Dev. 2012;58:223-30 pubmed
    To determine whether glucocorticoids affect the function of the bovine corpus luteum (CL) during the estrous cycle and early pregnancy, we examined the effects of exogenous cortisol or reduced endogenous cortisol on the secretion of ..
  24. Atli M, Bender R, Mehta V, Bastos M, Luo W, Vezina C, et al. Patterns of gene expression in the bovine corpus luteum following repeated intrauterine infusions of low doses of prostaglandin F2alpha. Biol Reprod. 2012;86:130 pubmed publisher
    ..The pattern of PGF-induced gene expression was similar in corpus luteum not destined for luteolysis (2X-non-regressed) after the first PGF pulse but was very distinct after the ..
  25. Rak Mardyła A, Gregoraszczuk E, Karpeta A, Duda M. Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3?-hydroxysteroid dehydrogenase (3?-honestly significant difference (HSD)) activi. Theriogenology. 2012;77:1505-12 pubmed publisher
  26. Kizuka F, Tokuda N, Takagi K, Adachi Y, Lee L, Tamura I, et al. Involvement of bone marrow-derived vascular progenitor cells in neovascularization during formation of the corpus luteum in mice. Biol Reprod. 2012;87:55 pubmed publisher
    Neovascularization is necessary for formation of the corpus luteum (CL) and includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood vessels by bone marrow-derived endothelial progenitor cells...
  27. Pate J, Johnson Larson C, Ottobre J. Life or death decisions in the corpus luteum. Reprod Domest Anim. 2012;47 Suppl 4:297-303 pubmed publisher
    The corpus luteum (CL) is an ephemeral endocrine organ...
  28. Hernandez F, Peluffo M, Stouffer R, Irusta G, Tesone M. Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat. Biol Reprod. 2011;84:859-65 pubmed publisher
    We investigated the expression and cell localization of NOTCH1, NOTCH4, and the delta-like ligand DLL4 in corpus luteum (CL) from pregnant rats during prostaglandin F2alpha (PGF2alpha)-induced luteolysis...
  29. Lüttgenau J, Ulbrich S, Beindorff N, Honnens A, Herzog K, Bollwein H. Plasma progesterone concentrations in the mid-luteal phase are dependent on luteal size, but independent of luteal blood flow and gene expression in lactating dairy cows. Anim Reprod Sci. 2011;125:20-9 pubmed publisher
    ..Results indicate that plasma P(4) concentrations in the mid-luteal phase were dependent on luteal size, but independent of blood flow and gene expression per luteal tissue unit...
  30. Woclawek Potocka I, Kowalczyk Zieba I, Tylingo M, Boruszewska D, Sinderewicz E, Skarzynski D. Effects of lysophopatidic acid on tumor necrosis factor ? and interferon ? action in the bovine corpus luteum. Mol Cell Endocrinol. 2013;377:103-11 pubmed publisher
    ..In conclusion our results indicate that LPA supports P4 synthesis and action in the bovine CL...
  31. Neglia G, Vecchio D, Russo M, Di Palo R, Pacelli C, Comin A, et al. Efficacy of PGF(2?) on pre-ovulatory follicle and corpus luteum blood flow. Reprod Domest Anim. 2012;47:26-31 pubmed publisher
    ..was to evaluate the effect of cloprostenol administration on the blood flow of pre-ovulatory follicle (PF) and corpus luteum (CL), progesterone secretion and pregnancy outcome in buffaloes subjected to AI...
  32. Maroni D, Davis J. TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum. J Cell Sci. 2011;124:2501-10 pubmed publisher
    Cyclical formation and regression of the ovarian corpus luteum is required for reproduction. During luteal regression, the microvasculature of the corpus luteum is extensively disrupted...
  33. Miyamoto A, Shirasuna K, Shimizu T, Bollwein H, Schams D. Regulation of corpus luteum development and maintenance: specific roles of angiogenesis and action of prostaglandin F2alpha. Soc Reprod Fertil Suppl. 2010;67:289-304 pubmed
    Development of the corpus luteum (CL) in ruminants occurs in a rapid and time-dependent manner within 1 week after ovulation, with morphologic and biochemical changes in the cells of the theca interna and granulosa cells of the ..
  34. Pate J, Toyokawa K, Walusimbi S, Brzezicka E. The interface of the immune and reproductive systems in the ovary: lessons learned from the corpus luteum of domestic animal models. Am J Reprod Immunol. 2010;64:275-86 pubmed publisher
    ..However, local cell-to-cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played ..
  35. McArt J, Caixeta L, Machado V, Guard C, Galvao K, Sá Filho O, et al. Ovsynch versus Ultrasynch: reproductive efficacy of a dairy cattle synchronization protocol incorporating corpus luteum function. J Dairy Sci. 2010;93:2525-32 pubmed publisher
    ..to compare the reproductive efficacy of Ultrasynch, a synchronization program based on functionality of the corpus luteum as determined by ultrasonography, with an Ovsynch protocol...
  36. Shirasuna K, Sasahara K, Matsui M, Shimizu T, Miyamoto A. Prostaglandin F2alpha differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow. J Reprod Dev. 2010;56:428-36 pubmed
    ..8-12 of the estrous cycle) drastically reduces the plasma progesterone concentrations and the volume of the corpus luteum (CL)...
  37. Townson D, Putnam A, Sullivan B, Guo L, Irving Rodgers H. Expression and distribution of cytokeratin 8/18 intermediate filaments in bovine antral follicles and corpus luteum: an intrinsic mechanism of resistance to apoptosis?. Histol Histopathol. 2010;25:889-900 pubmed publisher
    ..The prevalence and cell-specific pattern of cytokeratin expression in these structures is consistent with the concept these filaments might impart resistance to apoptosis in ovarian cells as is seen in other cell types...
  38. Choi J, Jo M, Lee E, Choi D. The role of autophagy in corpus luteum regression in the rat. Biol Reprod. 2011;85:465-72 pubmed publisher
    Autophagy is associated with luteal cells death during regression of the corpus luteum (CL) in some species. However, the involvement of autophagy or the association between autophagy and apoptosis in CL regression are largely unknown...
  39. Mondal M, Schilling B, Folger J, Steibel J, Buchnick H, Zalman Y, et al. Deciphering the luteal transcriptome: potential mechanisms mediating stage-specific luteolytic response of the corpus luteum to prostaglandin F??. Physiol Genomics. 2011;43:447-56 pubmed publisher
    ..Results reveal insight into stage-specific gene expression in bovine CL in response to PG and potential transcriptional mediators of luteolysis...
  40. Kumar L, Panda R, Hyder I, Yadav V, Sastry K, Sharma G, et al. Expression of leptin and its receptor in corpus luteum during estrous cycle in buffalo (Bubalus bubalis). Anim Reprod Sci. 2012;135:8-17 pubmed publisher
    ..The present study was aimed to investigate the importance of leptin and its receptors in buffalo corpus luteum (CL) obtained from different stages of the estrous cycle...
  41. Skarzynski D, Okuda K. Inter- and intra-cellular mechanisms of prostaglandin F2alpha action during corpus luteum regression in cattle. Soc Reprod Fertil Suppl. 2010;67:305-24 pubmed
    The bovine corpus luteum (CL) grows very fast and regresses within a few days at luteolysis...
  42. Zhao W, Cheng D, Zheng H, Zhu H, Ni J. [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010;26:313-7 pubmed
    To investigate the expression changes and regulation of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in corpus luteum during pregnancy.
  43. Shirasuna K, Jiemtaweeboon S, Raddatz S, Nitta A, Schuberth H, Bollwein H, et al. Rapid accumulation of polymorphonuclear neutrophils in the Corpus luteum during prostaglandin F(2?)-induced luteolysis in the cow. PLoS ONE. 2012;7:e29054 pubmed publisher
    ..PGF(2?)) induces luteolysis within a few days in cows, and immune cells increase in number in the regressing corpus luteum (CL), implying that luteolysis is an inflammatory-like immune response...
  44. Robinson R, Hammond A, Wathes D, Hunter M, Mann G. Corpus luteum-endometrium-embryo interactions in the dairy cow: underlying mechanisms and clinical relevance. Reprod Domest Anim. 2008;43 Suppl 2:104-12 pubmed publisher
    ..Interactions between the corpus luteum, endometrium and embryo are critical to the successful establishment of pregnancy and inadequacies will result ..
  45. Dickinson R, Stewart A, Myers M, Millar R, Duncan W. Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis. Endocrinology. 2009;150:2873-81 pubmed publisher
    ..Overall, these results imply expression of LHR splice variants is regulated in the human CL. Furthermore, during functional luteolysis a truncated variant could modulate the cell surface expression and activity of full-length LHR...
  46. Luz M, Bertan C, Binelli M, Lopes M. In vitro PGF2alpha production by endometrium and corpus luteum explants from pregnant and nonpregnant diestrus bitches and placental explants from pregnant bitches. Theriogenology. 2006;66:1442-7 pubmed
    ..that occurs prepartum, the present study investigated in vitro PGF2alpha production by the endometrium, corpus luteum and placental explants obtained at known times of the cycle from pregnant bitches (days 63, 64 and immediately ..
  47. Clementi M, Deis R, Telleria C. Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction. Reprod Biol Endocrinol. 2004;2:22 pubmed
  48. Campanile G, Di Palo R, Neglia G, Vecchio D, Gasparrini B, Prandi A, et al. Corpus luteum function and embryonic mortality in buffaloes treated with a GnRH agonist, hCG and progesterone. Theriogenology. 2007;67:1393-8 pubmed
    The effect of treatment with a GnRH agonist, hCG or progesterone (P(4)) on corpus luteum function and embryonic mortality was investigated in buffaloes inseminated during mid-winter...
  49. Sugino N, Suzuki T, Sakata A, Miwa I, Asada H, Taketani T, et al. Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab. 2005;90:6141-8 pubmed
    Blood vessel stabilization is regulated by angiopoietins and important for angiogenesis in the corpus luteum. To study angiogenesis and blood vessel stabilization in the human corpus luteum, changes in expression of angiopoietin (Ang)-1, ..
  50. Tamura H, Takasaki A, Taniguchi K, Matsuoka A, Shimamura K, Sugino N. Changes in blood-flow impedance of the human corpus luteum throughout the luteal phase and during early pregnancy. Fertil Steril. 2008;90:2334-9 pubmed publisher
    To examine changes in blood flow in the corpus luteum throughout the luteal phase and during early pregnancy. Longitudinal and cross-sectional prospective studies. University hospital and city general hospital...
  51. Bogan R, Murphy M, Stouffer R, Hennebold J. Prostaglandin synthesis, metabolism, and signaling potential in the rhesus macaque corpus luteum throughout the luteal phase of the menstrual cycle. Endocrinology. 2008;149:5861-71 pubmed publisher
    Prostaglandins in the corpus luteum (CL) reportedly serve as luteotropic and luteolytic agents...
  52. Répási A, Beckers J, Sulon J, Karen A, Reiczigel J, Szenci O. Effect of the type and number of prostaglandin treatments on corpus luteum, the largest follicle and progesterone concentration in dairy cows. Reprod Domest Anim. 2005;40:436-42 pubmed
    Lactating dairy cows (n = 72) with a mature corpus luteum (CL) (diameter of > or = 17 mm) determined by ultrasonography and having a follicle with a diameter of > or = 10 mm were randomly assigned to four groups...
  53. Hojo T, Al Zi abi M, Skarzynski D, Acosta T, Okuda K. Changes in the vasculature of bovine corpus luteum during the estrous cycle and prostaglandin F2alpha-induced luteolysis. J Reprod Dev. 2009;55:512-7 pubmed
    To investigate the possible role of the vasculature in the local regulation of corpus luteum (CL) function, we determined the densities of capillaries and large blood vessels in the center of the bovine CL during the estrous cycle and ..
  54. Contreras Solis I, Diaz T, Lopez G, Caigua A, Lopez Sebastian A, Gonzalez Bulnes A. Systemic and intraovarian effects of corpus luteum on follicular dynamics during estrous cycle in hair breed sheep. Anim Reprod Sci. 2008;104:47-55 pubmed
    ..5+/-0.1 compared with 3.3+/-0.1; P<0.01). Current results indicate that the presence of a functional CL may exert both systemic and local effects on the population of follicles, affecting the dominance exerted by large follicles. ..
  55. Powell S, Smith B, Timm K, Menino A. Expression of estrogen receptors alpha and beta in the corpus luteum and uterus from non-pregnant and pregnant llamas. Mol Reprod Dev. 2007;74:1043-52 pubmed
    ..in llamas, expression of estrogen receptor subtypes alpha (ERalpha) and beta (ERbeta) was evaluated in corpus luteum (CL), endometrium, and uterus using relative RT-PCR...
  56. Fraser H, Bell J, Wilson H, Taylor P, Morgan K, Anderson R, et al. Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum. J Clin Endocrinol Metab. 2005;90:427-34 pubmed
    Angiogenesis is essential for normal growth and function of the corpus luteum. The roles of various angiogenic factors in these events are being elucidated...
  57. Bergfelt D, Pierson R, Ginther O. Regression and resurgence of the CL following PGF2alpha treatment 3 days after ovulation in mares. Theriogenology. 2006;65:1605-19 pubmed
    ..The present study was designed to characterize and compare the physiology and ultrasonographic morphology of the corpus luteum (CL) during regression and resurgence following a single dose of native prostaglandin F2alpha (PGF) given 3 ..
  58. Acosta T, Bah M, Korzekwa A, Woclawek Potocka I, Markiewicz W, Jaroszewski J, et al. Acute changes in circulating concentrations of progesterone and nitric oxide and partial pressure of oxygen during prostaglandin F2alpha-induced luteolysis in cattle. J Reprod Dev. 2009;55:149-55 pubmed
  59. Järvelä I, Niinimäki M, Martikainen H, Ruokonen A, Tapanainen J. Ovarian response to the human chorionic gonadotrophin stimulation test in normal ovulatory women: the impact of regressing corpus luteum. Fertil Steril. 2007;87:1122-30 pubmed
    To evaluate the impact of the regressing corpus luteum on the hormone secretion during hCG stimulation...
  60. Taniguchi H, Komiyama J, Viger R, Okuda K. The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum. Mol Reprod Dev. 2009;76:873-80 pubmed publisher
    The corpus luteum (CL) is the major site of progesterone (P4) production during the luteal phase of the estrous cycle in cattle...
  61. Kaczmarek M, Schams D, Ziecik A. Role of vascular endothelial growth factor in ovarian physiology - an overview. Reprod Biol. 2005;5:111-36 pubmed
    ..Ovarian follicle and the corpus luteum (CL) have been shown to produce several angiogenic factors, however, vascular endothelial growth factor (VEGF) ..
  62. Kowalewski M, Mutembei H, Hoffmann B. Canine prostaglandin F2alpha receptor (FP) and prostaglandin F2alpha synthase (PGFS): molecular cloning and expression in the corpus luteum. Anim Reprod Sci. 2008;107:161-75 pubmed
    ..These data suggest that luteal regression in non-pregnant bitches is not modulated by PGF2alpha. However, the FP seems to be constitutionally expressed, explaining the receptivity of canine CL to exogenous PGF2alpha. ..
  63. Duncan W, van den Driesche S, Fraser H. Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum. Endocrinology. 2008;149:3313-20 pubmed publisher
    Vascular endothelial growth factor (VEGF)-dependent angiogenesis is crucial for follicular growth, and corpus luteum formation and function, in the primate ovary...
  64. Chakrabarti N, Subbarao T, Sengupta A, Xu F, Stouffer R, Sridaran R. Expression of mRNA and proteins for GnRH I and II and their receptors in primate corpus luteum during menstrual cycle. Mol Reprod Dev. 2008;75:1567-77 pubmed publisher
    The differential expression of mRNA and protein of GnRH I, II and their receptors (RI and RII) in the monkey corpus luteum (CL) were measured during different stages of the luteal phase of the menstrual cycle as an initial step towards ..
  65. Shirasuna K, Asahi T, Sasaki M, Shimizu T, Miyamoto A. Distribution of arteriolovenous vessels, capillaries and eNOS expression in the bovine corpus luteum during the estrous cycle: a possible implication of different sensitivity by luteal phase to PGF(2alpha) in the increase of luteal blood flow. J Reprod Dev. 2010;56:124-30 pubmed
    We have shown that luteal blood flow increases in the peripheral vasculature of the mature corpus luteum (CL) prior to the onset of luteolysis in response to prostaglandin F(2alpha) (PGF(2alpha)) in the cow, but this phenomenon does not ..
  66. Rosiansky Sultan M, Klipper E, Spanel Borowski K, Meidan R. Inverse relationship between nitric oxide synthases and endothelin-1 synthesis in bovine corpus luteum: interactions at the level of luteal endothelial cell. Endocrinology. 2006;147:5228-35 pubmed
    Endothelin-1 (ET-1) and nitric oxide (NO) play pivotal roles in corpus luteum (CL) function. The present study examined the interplay between NO and ET-1 synthesis in the bovine CL...
  67. Ratto M, Huanca W, Singh J, Adams G. Comparison of the effect of ovulation-inducing factor (OIF) in the seminal plasma of llamas, alpacas, and bulls. Theriogenology. 2006;66:1102-6 pubmed
    ..Ovulation and maximum corpus luteum diameter were compared by ultrasonography among female llamas (n=19 per group) treated intramuscularly with 2 ..
  68. Kliem H, Berisha B, Meyer H, Schams D. Regulatory changes of apoptotic factors in the bovine corpus luteum after induced luteolysis. Mol Reprod Dev. 2009;76:220-30 pubmed publisher
    The corpus luteum (CL) offers the opportunity to study not only proliferative, but also regressive processes. During luteolysis of the CL a sudden death of luteal and endothelial cells seems to be involved (apoptosis)...
  69. Acosta T, Yoshioka S, Komiyama J, Lee S, Grazul Bilska A, Skarzynski D, et al. Effects of storage and passage of bovine luteal endothelial cells on endothelin-1 and prostaglandin F2alpha production. J Reprod Dev. 2007;53:473-80 pubmed
    ..05) ET-1 and PGF2alpha production by the unfrozen and frozen-thawed LECs in all passages examined. Thus, LECs obtained from developing CLs and stored until passage 10 can be used for study of the physiology of LECs in vitro. ..
  70. Kliem H, Welter H, Kraetzl W, Steffl M, Meyer H, Schams D, et al. Expression and localisation of extracellular matrix degrading proteases and their inhibitors during the oestrous cycle and after induced luteolysis in the bovine corpus luteum. Reproduction. 2007;134:535-47 pubmed
    The corpus luteum (CL) offers the opportunity to study high proliferative processes during its development and degradation processes during its regression...
  71. Brylla E, Aust G, Geyer M, Uckermann O, Löffler S, Spanel Borowski K. Coexpression of preprotachykinin A and B transcripts in the bovine corpus luteum and evidence for functional neurokinin receptor activity in luteal endothelial cells and ovarian macrophages. Regul Pept. 2005;125:125-33 pubmed
    ..B (NKB), have been demonstrated in leukocytes, endothelial cells and endocrine cells, and may play a role in corpus luteum (CL) development...
  72. Kisliouk T, Podlovni H, Spanel Borowski K, Ovadia O, Zhou Q, Meidan R. Prokineticins (endocrine gland-derived vascular endothelial growth factor and BV8) in the bovine ovary: expression and role as mitogens and survival factors for corpus luteum-derived endothelial cells. Endocrinology. 2005;146:3950-8 pubmed
    A highly vascular endocrine gland, the corpus luteum (CL) is an excellent model for the study of angiogenic factors...
  73. Shirasuna K, Shimizu T, Hayashi K, Nagai K, Matsui M, Miyamoto A. Positive association, in local release, of luteal oxytocin with endothelin 1 and prostaglandin F2alpha during spontaneous luteolysis in the cow: a possible intermediatory role for luteolytic cascade within the corpus luteum. Biol Reprod. 2007;76:965-70 pubmed
    ..The bovine corpus luteum (CL) produces vasoactive substances, such as endothelin 1 (EDN1) and angiotensin II (Ang II), that mediate and ..
  74. Yang L, Wang X, Wan P, Zhang L, Wu Y, Tang D, et al. Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy. J Dairy Sci. 2010;93:1000-11 pubmed publisher
    ..by conceptus trophectoderm cells and induces expression of IFN-stimulated gene 15 (ISG15) in the uterus and corpus luteum (CL) in ewes...
  75. Tamanini C, De Ambrogi M. Angiogenesis in developing follicle and corpus luteum. Reprod Domest Anim. 2004;39:206-16 pubmed
    ..is essential to guarantee the necessary supply of nutrients and hormones to promote follicular growth and corpus luteum formation...
  76. Bachelot A, Beaufaron J, Servel N, Kedzia C, Monget P, Kelly P, et al. Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes. Am J Physiol Endocrinol Metab. 2009;297:E676-84 pubmed publisher
    The corpus luteum (CL) plays a central role in the maintenance of pregnancy in rodents, mainly by secreting progesterone...
  77. Sakumoto R, Komatsu T, Kasuya E, Saito T, Okuda K. Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle. Domest Anim Endocrinol. 2006;31:246-57 pubmed
    There is increasing evidence that inflammatory cytokines regulate corpus luteum (CL) function in many species...
  78. Berisha B, Meyer H, Schams D. Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum. Biol Reprod. 2010;82:940-7 pubmed publisher
    The essential role of endometrial prostaglandin F2 alpha (PTGF) for induction of the corpus luteum (CL) regression is well documented in the cow...
  79. Aguilar J, Fraser H, Wilson H, Clutton E, Shaw D, Watson E. Temporal relationship between proliferating and apoptotic hormone-producing and endothelial cells in the equine corpus luteum. Reproduction. 2006;132:111-8 pubmed
    ..However, there is no evidence that endothelial cell death is the trigger for naturally occurring luteolysis...
  80. Miyamoto A, Shirasuna K, Sasahara K. Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors. Domest Anim Endocrinol. 2009;37:159-69 pubmed publisher
    The corpus luteum (CL) of the estrous cycle in the cow is a dynamic organ which has a life time of approximately 17-18 days...