fallopian tubes

Summary

Summary: A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.

Top Publications

  1. Shaw J, Wills G, Lee K, Horner P, McClure M, Abrahams V, et al. Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NF?B activation resulting in a microenvironment predisposed to ectopic pregnancy. Am J Pathol. 2011;178:253-60 pubmed publisher
    ..trachomatis-induced PROKR2 expression. We propose that ligation of tubal TLR2 and activation of NF?B by C. trachomatis leads to increased tubal PROKR2, thereby predisposing the tubal microenvironment to ectopic implantation...
  2. Shao R, Norstrom A, Weijdegård B, Egecioglu E, Fernandez Rodriguez J, Feng Y, et al. Distinct expression pattern of Dicer1 correlates with ovarian-derived steroid hormone receptor expression in human Fallopian tubes during ovulation and the midsecretory phase. J Clin Endocrinol Metab. 2011;96:E869-77 pubmed publisher
    ..Tissue-specific dicer1 knockout mice display severe, irreversible Fallopian tube damage and disrupted tubal transport. It is not known how Dicer1 affects human Fallopian tube function...
  3. Hunter R. Components of oviduct physiology in eutherian mammals. Biol Rev Camb Philos Soc. 2012;87:244-55 pubmed publisher
    ..Additionally, primate endometrial secretions may be modified by viable gametes or an embryo in the presence of a cumulus cell suspension...
  4. Diaz P, Solar P, Juica N, Orihuela P, Cardenas H, Christodoulides M, et al. Differential expression of extracellular matrix components in the Fallopian tubes throughout the menstrual cycle. Reprod Biol Endocrinol. 2012;10:56 pubmed publisher
    ..Multiple components of the extracellular matrix take part in this tissue rebuilding; however, the individual components involved have not been identified...
  5. Bahar Shany K, Brand H, Sapoznik S, Jacob Hirsch J, Yung Y, Korach J, et al. Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma. Gynecol Oncol. 2014;132:322-7 pubmed publisher
    ..Our aim is to develop such an ex-vivo model based on human fallopian tube (FT) epithelium exposed to human follicular fluid (FF)...
  6. Aviles M, Gutierrez Adan A, Coy P. Oviductal secretions: will they be key factors for the future ARTs?. Mol Hum Reprod. 2010;16:896-906 pubmed publisher
    ..b>Fallopian tubes are a particularly interesting example of such organs...
  7. Mehrad M, Ning G, Chen E, Mehra K, CRUM C. A pathologist's road map to benign, precancerous, and malignant intraepithelial proliferations in the fallopian tube. Adv Anat Pathol. 2010;17:293-302 pubmed publisher
    ..Finally, the rationale for close inspection of the tube, both in presumed benign and malignant disease, is discussed, with reference to an ongoing multi-institutional web-based project (Pelvic-ovarian Cancer Interception project)...
  8. Przybycin C, Kurman R, Ronnett B, Shih I, Vang R. Are all pelvic (nonuterine) serous carcinomas of tubal origin?. Am J Surg Pathol. 2010;34:1407-16 pubmed publisher
    ..The presence of TIC and its location and relationship to invasive carcinoma in the fallopian tubes and ovaries were assessed...
  9. Karst A, Levanon K, Drapkin R. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A. 2011;108:7547-52 pubmed publisher
    ..model is based on (i) immortalization of FTSECs isolated from primary samples of normal, nondiseased human fallopian tubes, (ii) transformation of FTSECs with defined genetic elements, and (iii) xenograft-based tumorigenic assays...

More Information

Publications107 found, 100 shown here

  1. Fotheringham S, Levanon K, Drapkin R. Ex vivo culture of primary human fallopian tube epithelial cells. J Vis Exp. 2011;: pubmed publisher
    ..This ex vivo model provides a useful tool for the study of SOC, allowing a better understanding of how tumors can arise from this tissue, and the mechanisms involved in tumor initiation and progression...
  2. Hermanny A, Bahamondes M, Fazano F, Marchi N, Ortiz M, Genghini M, et al. In vitro assessment of some sperm function following exposure to levonorgestrel in human fallopian tubes. Reprod Biol Endocrinol. 2012;10:8 pubmed publisher
    ..The aim of this study was to assess whether LNG at a similar dose to those found in serum following oral intake for EC could affect spermatozoa when exposed to human fallopian tubes in vitro.
  3. Kim J, Coffey D, Creighton C, Yu Z, Hawkins S, Matzuk M. High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012;109:3921-6 pubmed publisher
    ..Thus, this mouse model demonstrates a paradigm for the origin and initiation of high-grade serous ovarian carcinomas, the most common and deadliest ovarian cancer...
  4. Osycka Salut C, Gervasi M, Pereyra E, Cella M, Ribeiro M, Franchi A, et al. Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. PLoS ONE. 2012;7:e30671 pubmed publisher
    ..These findings suggest that anandamide regulates the sperm release from oviductal epithelia probably by activating the NO pathway during sperm capacitation...
  5. Vang R, Shih I, Kurman R. Fallopian tube precursors of ovarian low- and high-grade serous neoplasms. Histopathology. 2013;62:44-58 pubmed publisher
    ..This review paper provides an overview of the fallopian tube's potential role in the pathogenesis of both types of serous neoplasms of the ovary...
  6. Saruhan B, Sagsoz H, Akbalik M, Ketani M. Distribution of estrogen receptor ? and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study. Biotech Histochem. 2011;86:315-25 pubmed publisher
    ..05). We results indicated that the frequency and intensity of ER? and PR-? immunoreactivity in the oviduct of bovines varied according to the oviductal cell types and the phases of the sexual cycle...
  7. Crum C, Xian W. Bringing the p53 signature into focus. Cancer. 2010;116:5119-21 pubmed publisher
  8. Okada T, Sasaki S, Honda S, Miyagi H, Minato M, Todo S. Irreducible indirect inguinal hernia containing uterus, ovaries, and Fallopian tubes. Hernia. 2012;16:471-3 pubmed publisher
    An indirect inguinal hernia containing the entire uterus, ovaries, and Fallopian tubes is extremely rare in pediatrics...
  9. Saunders R, Shwayder J, Nakajima S. Current methods of tubal patency assessment. Fertil Steril. 2011;95:2171-9 pubmed publisher
    ..To evaluate the scientific literature on current methods of uterine cavity and tubal patency assessment...
  10. Brown J, Horne A. Laboratory models for studying ectopic pregnancy. Curr Opin Obstet Gynecol. 2011;23:221-6 pubmed publisher
    ..We aim to summarize the latest advances in laboratory models of tEP that we believe will, ultimately, contribute to improving the diagnosis and management of the condition...
  11. Kessler M, Zielecki J, Thieck O, Mollenkopf H, Fotopoulou C, Meyer T. Chlamydia trachomatis disturbs epithelial tissue homeostasis in fallopian tubes via paracrine Wnt signaling. Am J Pathol. 2012;180:186-98 pubmed publisher
    ..Ascending genital infections cause inflammation of fallopian tubes and subsequent scarring and occlusion. The cellular basis for such sequelae remains undetermined...
  12. Velasquez L, García K, Morales F, Heckels J, Orihuela P, Rodas P, et al. Neisseria gonorrhoeae pilus attenuates cytokine response of human fallopian tube explants. J Biomed Biotechnol. 2012;2012:491298 pubmed publisher
  13. Gebeh A, Willets J, Marczylo E, Taylor A, Konje J. Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. J Clin Endocrinol Metab. 2012;97:2827-35 pubmed publisher
    ..g. N-acyl-phosphatidylethanolamine-specific phospholipase D), forms the endocannabinoid system. High anandamide levels are associated with tubal arrest of embryos in mice and may have a similar role in women...
  14. Shaw J, Oliver E, Lee K, Entrican G, Jabbour H, Critchley H, et al. Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol. 2010;177:2509-15 pubmed publisher
    ..05), which was negated by cotreatment with nAChR?-7 antagonist. Smoking targets human FTs via nAChR?-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to EP...
  15. Luciano D, Exacoustos C, Johns D, Luciano A. Can hysterosalpingo-contrast sonography replace hysterosalpingography in confirming tubal blockage after hysteroscopic sterilization and in the evaluation of the uterus and tubes in infertile patients?. Am J Obstet Gynecol. 2011;204:79.e1-5 pubmed publisher
  16. Kenngott R, Vermehren M, Sauer U, Ebach K, Sinowatz F. Cellular expression and localization of estrogen receptor ? and progesterone receptor mRNA in the bovine oviduct combining laser-assisted microdissection, quantitative PCR, and in situ hybridization. J Histochem Cytochem. 2011;59:312-27 pubmed publisher
    ..In conclusion, the authors found that LAM with qPCR can precisely locate and accurately quantify mRNA expression in specific cell populations from formalin-fixed and paraffin-embedded oviductal tissue...
  17. George S, Greenaway J, Milea A, Clary V, Shaw S, Sharma M, et al. Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers. J Pathol. 2011;225:106-17 pubmed publisher
    ..The altered expression profiles in histologically normal tubal epithelium from BRCA1 heterozygotes suggest that these cells may respond differently to microenvironmental stresses...
  18. El Hakim E, Epee M, Draycott T, Gordon U, Akande V. Significance of positive Chlamydia serology in women with normal-looking Fallopian tubes. Reprod Biomed Online. 2009;19:847-51 pubmed
    ..These findings suggest that laparoscopic findings and not Chlamydia serological titres are the key to prognosis...
  19. Bowen N, Logani S, Dickerson E, Kapa L, Akhtar M, Benigno B, et al. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol. 2007;104:331-7 pubmed
    ..These findings support the hypothesis that PAX8 plays parallel roles in the development of epithelial ovarian cancer and in the developmental differentiation of coelomic epithelia into endosalpingeal epithelia. ..
  20. Jagannath S, Kantsevoy S, Vaughn C, Chung S, Cotton P, Gostout C, et al. Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model. Gastrointest Endosc. 2005;61:449-53 pubmed
    ..We now report successful performance of peroral endoscopic transgastric ligation of Fallopian tubes with long-term survival in a porcine model...
  21. Marquez R, Baggerly K, Patterson A, Liu J, Broaddus R, Frumovitz M, et al. Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res. 2005;11:6116-26 pubmed
    ..This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers with that in the normal tissues that they resemble...
  22. Briton Jones C, Lok I, Cheung C, Po A, Chiu T, Haines C. Ratio of mRNA expression of progesterone receptor isoforms AB is to B in human oviduct mucosal cells during the ovulatory cycle. J Assist Reprod Genet. 2005;22:429-35 pubmed
    ..Providing support for the hypothesis that progesterone may play a specific role in providing an appropriate environment for sperm capacitation, fertilization and early embryo cleavage. ..
  23. Wicherek L, Galazka K, Popiela T, Dutsch Wicherek M, Czekierdowski A, Pabian W, et al. Metallothionein expression and infiltration of cytotoxic lymphocytes in uterine and tubal implantation sites. J Reprod Immunol. 2006;70:119-31 pubmed
    ..The concentration of immune cells and increase of their activity in tubal mucosa, with insufficient protection against immune-mediated apoptosis assessed by MT expression, might result in tubal rupture during ectopic pregnancy. ..
  24. Mönkkönen K, Aflatoonian R, Lee K, Yeung W, Tsao S, Laitinen J, et al. Localization and variable expression of G alpha(i2) in human endometrium and Fallopian tubes. Hum Reprod. 2007;22:1224-30 pubmed
    ..Significantly variable expression of G alpha(i2) during the menstrual cycle suggests G alpha(i2) might be under hormonal regulation in the female reproductive tract in vivo. ..
  25. Wånggren K, Stavreus Evers A, Olsson C, Andersson E, Gemzell Danielsson K. Regulation of muscular contractions in the human Fallopian tube through prostaglandins and progestagens. Hum Reprod. 2008;23:2359-68 pubmed publisher
    ..The ampullary-isthmic junction of the Fallopian tubes was excised and used for in vitro contractility studies...
  26. Suarez S. Regulation of sperm storage and movement in the mammalian oviduct. Int J Dev Biol. 2008;52:455-62 pubmed publisher
    ..Hyperactivation likely assists sperm in penetrating the cumulus matrix and is absolutely required for penetrating the oocyte zona pellucida and achieving fertilization. ..
  27. Kilic S, Tasdemir N, Lortlar N, Yuksel B, Budak G, Batioglu S. Vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) immunoreactivities in rat ovaries and uterine tubes after tubal ligation: a controlled immunohistochemical study. Eur J Contracept Reprod Health Care. 2008;13:431-7 pubmed publisher
    ..209) was of similar intensity in both groups. Tubal ligation may lead to supraphysiological hypoxia as evidenced by increased VEGF and iNOS immunoreactivities in ovarian and tubal tissues. ..
  28. Wånggren K, Lalitkumar P, Stavreus Evers A, Ståbi B, Gemzell Danielsson K. Prostaglandin E2 and F2alpha receptors in the human Fallopian tube before and after mifepristone treatment. Mol Hum Reprod. 2006;12:577-85 pubmed
    ..Laparoscopic sterilization was performed on days LH+4 to LH+6. Biopsies were taken from the Fallopian tubes bilaterally. The expression of EP1, EP2, EP3, EP4 and FP was analysed using immunohistochemistry and RT-PCR...
  29. Georgiou A, Snijders A, Sostaric E, Aflatoonian R, Vazquez J, Vazquez J, et al. Modulation of the oviductal environment by gametes. J Proteome Res. 2007;6:4656-66 pubmed
    ..In addition, the presence of a gamete recognition system explains the oviduct's ability to tolerate spermatozoa while remaining intolerant to pathogens. ..
  30. Tone A, Begley H, Sharma M, Murphy J, Rosen B, Brown T, et al. Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma. Clin Cancer Res. 2008;14:4067-78 pubmed publisher
  31. Itoh H, Nasu K, Matsumoto H, Kawano Y, Yoshimatsu J, Narahara H. Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts. Fertil Steril. 2006;85 Suppl 1:1097-102 pubmed
    ..The modulation of the bias of VEGF and sFlt-1 in the fallopian tubes may contribute to the normal and pathological processes of oviductal fluid secretion by regulating oviductal ..
  32. Zhang M, Hong H, Zhou B, Jin S, Wang C, Fu M, et al. The expression of atrial natriuretic peptide in the oviduct and its functions in pig spermatozoa. J Endocrinol. 2006;189:493-507 pubmed
    ..These results suggest that the expression of ANP in the oviduct may be involved in the regulation of the acrosome reaction and the fertilising ability of pig spermatozoa, and the PKG pathway possibly participates in the process. ..
  33. Dharia Patel S, Steinkampf M, Whitten S, Malizia B. Robotic tubal anastomosis: surgical technique and cost effectiveness. Fertil Steril. 2008;90:1175-9 pubmed
    ..00, OPEN $92,205.90). Robotically assisted laparoscopic microsurgical tubal anastomosis is feasible and cost effective with results that are comparable with the traditional open approach. ..
  34. Refaat B, Amer S, Ola B, Chapman N, Ledger W. The expression of activin-betaA- and -betaB-subunits, follistatin, and activin type II receptors in fallopian tubes bearing an ectopic pregnancy. J Clin Endocrinol Metab. 2008;93:293-9 pubmed
    ..We investigated whether epithelia from Fallopian tubes (FTs) bearing an ectopic pregnancy differ from normal tubes in expression of TGF-beta family and related ..
  35. Prantner D, Darville T, Sikes J, Andrews C, Brade H, Rank R, et al. Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages. Infect Immun. 2009;77:5334-46 pubmed publisher
    ..Additionally, prestimulation of macrophages by chlamydial TLR ligands may account for the elevated levels of pro-IL-1beta mRNA observed in vivo in this cell type...
  36. Sun X, Gemzell Danielsson K, Li H, Ståbi B, Stavreus Evers A. Expression of heparin-binding epidermal growth factor-like growth factor and its receptors in the human fallopian tube and endometrium after treatment with mifepristone. Fertil Steril. 2006;85:171-8 pubmed
    ..Endometrial biopsies from 30 women were obtained during one control cycle or one treatment cycle. Fallopian tubes from 14 women were collected during laparoscopic sterilizations...
  37. Dixon R, Hwang S, Hennig G, Ramsey K, Schripsema J, Sanders K, et al. Chlamydia infection causes loss of pacemaker cells and inhibits oocyte transport in the mouse oviduct. Biol Reprod. 2009;80:665-73 pubmed publisher
    ..This, accompanied by retention of oviduct secretions, may contribute to the development of tubal factor infertility. ..
  38. Brito K, Bahamondes L, Nascimento J, de Santis L, Munuce M. The in vitro effect of emergency contraception doses of levonorgestrel on the acrosome reaction of human spermatozoa. Contraception. 2005;72:225-8 pubmed
    ..If this effect exists or if there is any other that influences sperm fertilizing capacity, in vitro experiments are probably not an appropriate way of testing it. ..
  39. Teilmann S, Clement C, Thorup J, Byskov A, Christensen S. Expression and localization of the progesterone receptor in mouse and human reproductive organs. J Endocrinol. 2006;191:525-35 pubmed
    ..These novel findings warrant further studies of oviduct and postovulatory signaling events and suggest a sensory role for oviduct cilia in the process of oocyte transport/fertilization. ..
  40. Horree N, Heintz A, Sie Go D, van Diest P. p16 is consistently expressed in endometrial tubal metaplasia. Cell Oncol. 2007;29:37-45 pubmed
    ..inactive endometrium with TM (n=15), ovarian inclusion cysts (n=6), cervix with TM (tubal metaplasia) (n=3), Fallopian tubes (n=7), cycling endometrium (n=9) and a ciliated cell tumor of the ovary were stained for p16 and LhS28...
  41. Nutu M, Weijdegård B, Thomas P, Bergh C, Thurin Kjellberg A, Pang Y, et al. Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Mol Reprod Dev. 2007;74:843-50 pubmed
    ..The presence of mPRgamma in lung and liver of mice suggests that the receptor mediates the actions of progesterone outside the reproductive tract as well. ..
  42. Wicherek L. The role of the endometrium in the regulation of immune cell activity. Front Biosci. 2008;13:1018-35 pubmed
    ..The determination of the mechanisms responsible for endometrial participation in immune tolerance during pregnancy could have important clinical consequences and may prove significant in the development of immunotherapy. ..
  43. Barnhart K. Clinical practice. Ectopic pregnancy. N Engl J Med. 2009;361:379-87 pubmed publisher
  44. Derbigny W, Kerr M, Johnson R. Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines. J Immunol. 2005;175:6065-75 pubmed
    ..muridarum-infected oviduct epithelial cell lines. The pattern recognition molecule responsible for infection-induced IFN-beta secretion by oviduct epithelial cells remains to be determined...
  45. Reyes P, Vargas M, García K, Rubilar P, Navarrete P, Fuentes P, et al. Apoptosis related genes expressed in cultured Fallopian tube epithelial cells infected in vitro with Neisseria gonorrhoeae. Biol Res. 2007;40:319-27 pubmed publisher
    Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae (Ngo) can lead to acute salpingitis, an inflammatory condition resulting in damage primarily to the ciliated cells, with loss of ciliary activity and sloughing of the cells ..
  46. Locatelli Y, Cognie Y, Vallet J, Baril G, Verdier M, Poulin N, et al. Successful use of oviduct epithelial cell coculture for in vitro production of viable red deer (Cervus elaphus) embryos. Theriogenology. 2005;64:1729-39 pubmed
    ..Ten blastocysts from oOEC coculture were transferred after freezing and thawing to five recipient hinds and gave rise to three pregnancies. The three pregnant hinds gave birth to three live and normal calves. ..
  47. Shao R, Weijdegård B, Ljungström K, Friberg A, Zhu C, Wang X, et al. Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function. Am J Physiol Endocrinol Metab. 2006;291:E59-72 pubmed
  48. Lapointe J, Roy M, St Pierre I, Kimmins S, Gauvreau D, Maclaren L, et al. Hormonal and spatial regulation of nitric oxide synthases (NOS) (neuronal NOS, inducible NOS, and endothelial NOS) in the oviducts. Endocrinology. 2006;147:5600-10 pubmed
    ..Our results suggest that neuronal NOS, iNOS, and endothelial NOS contribute to oviductal functions in a timely and site-specific manner. ..
  49. Lee Y, Miron A, Drapkin R, Nucci M, Medeiros F, Saleemuddin A, et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2007;211:26-35 pubmed
    ..non-neoplastic tubes from BRCA+ women and controls, but more frequently present (53%) and multifocal (67%) in fallopian tubes also containing TIC...
  50. Gaytan M, Morales C, Bellido C, Sanchez Criado J, Gaytan F. Macrophages in human fallopian tube and ovarian epithelial inclusion cysts. J Reprod Immunol. 2007;73:66-73 pubmed
    ..analyse the presence and numbers of macrophages in the ovarian surface epithelium (OSE), in EICs, and in the fallopian tubes, as tubal metaplasia is a common finding in EICs...
  51. Folkins A, Jarboe E, Saleemuddin A, Lee Y, Callahan M, Drapkin R, et al. A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. Gynecol Oncol. 2008;109:168-73 pubmed publisher
    ..This study compared the prevalence of p53 signatures in ovarian cortical inclusion cysts (CICs) and fallopian tubes from BRCA+ women and explored their relationship...
  52. Carlson J, Miron A, Jarboe E, Parast M, Hirsch M, Lee Y, et al. Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention. J Clin Oncol. 2008;26:4160-5 pubmed publisher
    ..This study examined the frequency of STIC in PPSC and its clinical outcome in BRCA-positive women...
  53. Machado Oliveira G, Lefievre L, Ford C, Herrero M, Barratt C, Connolly T, et al. Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract. Development. 2008;135:3677-86 pubmed publisher
  54. Smith J, Wira C, Fanger M, Shen L. Human fallopian tube neutrophils--a distinct phenotype from blood neutrophils. Am J Reprod Immunol. 2006;56:218-29 pubmed
    ..Fallopian tube neutrophils exhibit a phenotype distinct from PB neutrophils, suggesting functional activation of innate immune defense in the female reproductive tract as well as a potential role in maintaining normal FT physiology. ..
  55. Shao R, Weijdegård B, Fernandez Rodriguez J, Egecioglu E, Zhu C, Andersson N, et al. Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo. Am J Physiol Endocrinol Metab. 2007;293:E147-58 pubmed
    ..We have investigated the intracellular localization and regulatory patterns for ERbeta isoforms in rat fallopian tubes. Western blot analysis reveals that two ERbeta isoforms corresponding to ERbeta1 and ERbeta2 are expressed in ..
  56. Hvid M, Baczynska A, Deleuran B, Fedder J, Knudsen H, Christiansen G, et al. Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol. 2007;9:2795-803 pubmed
    ..To explore the molecular mechanisms behind infection an ex vivo model was established from human Fallopian tubes and examined by scanning electron microscopy and immunohistochemistry...
  57. Levanon K, Crum C, Drapkin R. New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J Clin Oncol. 2008;26:5284-93 pubmed publisher
    ..With the rise of the fallopian tube secretory epithelial cell as a cell of origin for high-grade pelvic serous carcinomas, the need to develop tools and model systems to characterize the biology and physiology of this cell is recognized...
  58. Folkins A, Jarboe E, Roh M, Crum C. Precursors to pelvic serous carcinoma and their clinical implications. Gynecol Oncol. 2009;113:391-6 pubmed publisher
    ..The data supporting a candidate precursor, the implications of these findings for early detection and prevention of pelvic serous carcinoma and the caveats, are discussed...
  59. Jazedje T, Perin P, Czeresnia C, Maluf M, Halpern S, Secco M, et al. Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures. J Transl Med. 2009;7:46 pubmed publisher
    ..this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs)...
  60. Kurman R, Shih I. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol. 2010;34:433-43 pubmed publisher
    ..Appreciation of these new concepts will allow for a more rationale approach to screening, treatment, and prevention that potentially can have a significant impact on reducing the mortality of this devastating disease. ..
  61. Lyons R, Saridogan E, Djahanbakhch O. The effect of ovarian follicular fluid and peritoneal fluid on Fallopian tube ciliary beat frequency. Hum Reprod. 2006;21:52-6 pubmed
    ..Peritoneal fluid was collected from six women undergoing laparoscopic sterilization. Fallopian tubes were collected from 10 women who underwent hysterectomy for benign conditions...
  62. Lakshman N, Chang R, Ho Y. Laparoscopic combined rectal anterior resection and total hysterectomy with bilateral salpingo-oophorectomy. Tech Coloproctol. 2006;10:350-2 pubmed
    ..Our results confirm that LapAR & THBSO is feasible and offers the advantages of a laparoscopic procedure in the hands of a well trained laparoscopic colorectal surgeon and gynaecologist working together. ..
  63. Ulbrich S, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, et al. Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro. J Endocrinol. 2006;188:205-13 pubmed
    ..The region-specific modulated expression of eNOS and iNOS provides evidence for an involvement of endogenously produced NO in the regulation of oviductal functions...
  64. Orihuela P, Parada Bustamante A, Zúñiga L, Croxatto H. Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats. J Endocrinol. 2006;188:579-88 pubmed
    ..These findings clearly illustrate a non-genomic pathway triggered by E(2) that regulates a complex physiologic process accomplished by an entire organ...
  65. Kölle S, Dubielzig S, Reese S, Wehrend A, Konig P, Kummer W. Ciliary transport, gamete interaction, and effects of the early embryo in the oviduct: ex vivo analyses using a new digital videomicroscopic system in the cow. Biol Reprod. 2009;81:267-74 pubmed publisher
    ..The early embryo is able to induce the formation of secretory cells, modify vascularization, and downregulate speed of transport, thus creating the prerequisite for the first embryo-maternal communication in the oviduct...
  66. Ohman H, Tiitinen A, Halttunen M, Lehtinen M, Paavonen J, Surcel H. Cytokine polymorphisms and severity of tubal damage in women with Chlamydia-associated infertility. J Infect Dis. 2009;199:1353-9 pubmed publisher
    ..trachomatis (odds ratio [OR], 7.3 [95% confidence interval {CI}, 1.3-42] and 4.0 [95% CI, 1.0-16], respectively), suggesting that differences in these genes contribute to the wide spectrum of disease manifestations...
  67. Hart K, Murphy A, Barrett K, Wira C, Guyre P, Pioli P. Functional expression of pattern recognition receptors in tissues of the human female reproductive tract. J Reprod Immunol. 2009;80:33-40 pubmed publisher
    ..Results of these studies indicate that PRRs are functionally expressed in FRT tissues, and suggest that these receptors mediate microbial recognition and immune defense in the reproductive tract...
  68. Shao R, Nutu M, Karlsson Lindahl L, Benrick A, Weijdegård B, Lager S, et al. Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes. Am J Physiol Cell Physiol. 2009;297:C140-51 pubmed publisher
    ..Although IL-6 was recently shown to inhibit cilia activity in human fallopian tubes in vitro, the molecular mechanisms underlying IL-6 signaling to tubal function remain elusive...
  69. Hess A, Baston Buest D, Schanz A, Hirchenhain J, Bielfeld P, Kruessel J. Interleukin-1 system in the human fallopian tube-No spatial but a temporal regulation of mRNA and protein expression. Mol Cell Endocrinol. 2009;303:7-12 pubmed publisher
  70. Qian Y, Shi W, Ding J, Liu J, Sha J, Fan B. Effects of type and state of co-culture cells on in-vitro development of porcine oocytes matured and fertilized in vitro. J Assist Reprod Genet. 2005;22:233-8 pubmed
    ..The present study was to investigate the impact of type and state of co-culture cells on developmental competence of porcine oocytes matured and fertilized in vitro...
  71. Wijayagunawardane M, Kodithuwakku S, Yamamoto D, Miyamoto A. Vascular endothelial growth factor system in the cow oviduct: a possible involvement in the regulation of oviductal motility and embryo transport. Mol Reprod Dev. 2005;72:511-20 pubmed
  72. Song Y, Kang J, Park M. Fallopian tube prolapse misdiagnosed as vault granulation tissue: a report of three cases. Pathol Res Pract. 2005;201:819-22 pubmed
    ..It is necessary to receive a pathologic confirmation by performing vaginal biopsy when fallopian tube prolapse is clinically suspected, thus preventing misdiagnosis...
  73. Rottmayer R, Ulbrich S, Kölle S, Prelle K, Neumueller C, Sinowatz F, et al. A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization. Reproduction. 2006;132:637-48 pubmed
    ..Our novel culture system provides functional BOECs in sufficient quantities for holistic transcriptome and proteome studies, e.g. for deciphering early embryo-maternal communication...
  74. Shao R, Egecioglu E, Weijdegård B, Kopchick J, Fernandez Rodriguez J, Andersson N, et al. Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors. Am J Physiol Endocrinol Metab. 2007;293:E1430-42 pubmed
    ..Recently, we identified ERbeta expression and localization in rat fallopian tubes, suggesting a potential biological function of ERbeta related to calcium-dependent ciliated beating...
  75. Carrasco L, Romar R, Aviles M, Gadea J, Coy P. Determination of glycosidase activity in porcine oviductal fluid at the different phases of the estrous cycle. Reproduction. 2008;136:833-42 pubmed publisher
    ..7+/-1.3 microl/oviduct). These results indicate that OF from sows and gilts shows glycosidase activity varying throughout the estrous cycle suggesting a role of these enzymes in carbohydrate-mediated events...
  76. Deleuze S, Dubois C, Caillaud M, Bruneau B, Goudet G, Duchamp G. Influence of cysteamine on in vitro maturation, in vitro and in vivo fertilization of equine oocytes. Reprod Domest Anim. 2010;45:1-7 pubmed publisher
    ..Those two percentages were not statistically different (p > 0.05). No effect of IVF technique was seen on the success rate (6%) in each group...
  77. Gervasi M, Rapanelli M, Ribeiro M, Farina M, Billi S, Franchi A, et al. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. Reproduction. 2009;137:403-14 pubmed publisher
  78. King A, Wheelhouse N, Cameron S, McDonald S, Lee K, Entrican G, et al. Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Hum Reprod. 2009;24:679-86 pubmed publisher
    ..They have been demonstrated at multiple mucosal surfaces including those of the female reproductive tract...
  79. Deleuze S, Goudet G, Caillaud M, Lahuec C, Duchamp G. Efficiency of embryonic development after intrafollicular and intraoviductal transfer of in vitro and in vivo matured horse oocytes. Theriogenology. 2009;72:203-9 pubmed publisher
    ..Our results also suggest that improvement of the IFOT technique could turn it into an inexpensive and easy-to-perform procedure that could be an answer to the inefficiency of superovulation treatments in the mare...
  80. Refaat B, Al Azemi M, Geary I, Eley A, Ledger W. Role of activins and inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection. Clin Vaccine Immunol. 2009;16:1493-503 pubmed publisher
    ..Blood and fallopian tubes were collected from 14 women with EP...
  81. Nutu M, Weijdegård B, Thomas P, Thurin Kjellberg A, Billig H, Larsson D. Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. Reprod Biol Endocrinol. 2009;7:89 pubmed publisher
    ..Rapid effects of progesterone on ciliary beat frequency have been reported in the fallopian tubes of cows, but the identity of the receptors mediating this non-genomic action of progesterone is not known...
  82. Levanon K, Ng V, Piao H, Zhang Y, Chang M, Roh M, et al. Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis. Oncogene. 2010;29:1103-13 pubmed publisher
    ..We anticipate that this novel culture system will facilitate the study of SOC pathogenesis, and propose that similar culture systems could be developed for other organ site-specific epithelia...
  83. Shao R. Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models. Hum Reprod. 2010;25:584-7 pubmed publisher
    ..Our understanding of the mechanisms which contribute to tubal ectopic pregnancy in humans may be enhanced through further study of these KO mouse models...
  84. Itoh H, Nasu K, Nishida M, Matsumoto H, Yuge A, Narahara H. Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4: the site-specific mucosal immunity of the human fallopian tube against bacterial infection. Am J Reprod Immunol. 2006;56:91-101 pubmed
    To evaluate the site-specific immunoregulatory mechanisms against bacterial infection in the human fallopian tubes.
  85. Hao Y, Mathialagan N, Walters E, Mao J, Lai L, Becker D, et al. Osteopontin reduces polyspermy during in vitro fertilization of porcine oocytes. Biol Reprod. 2006;75:726-33 pubmed
    ..The current study represents the first report to demonstrate that SPP1 plays an important role in the regulation of pig polyspermic fertilization; it decreases polyspermy and increases fertilization efficiency during IVF...
  86. Baczynska A, Funch P, Fedder J, Knudsen H, Birkelund S, Christiansen G. Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis--in vitro organ culture study. Hum Reprod. 2007;22:968-79 pubmed
    Female infertility can be caused by scarring and occlusion of the Fallopian tubes. Sexually transmitted bacteria can damage the delicate epithelial layer of human Fallopian tubes (HFT)...
  87. Crum C, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res. 2007;5:35-44 pubmed
    ..Emerging studies that carefully examine the fallopian tubes suggest a high frequency of early cancer in the fimbria in unselected women with ovarian and peritoneal ..
  88. Mönkkönen K, Aflatoonian R, Lee K, Yeung W, Tsao S, Laitinen J, et al. Hormonal regulation of Galphai2 and mPRalpha in immortalized human oviductal cell line OE-E6/E7. Mol Hum Reprod. 2007;13:845-51 pubmed
    ..Our results suggest that estrogen receptor ERbeta mediates the regulatory effects of estradiol in these cells...
  89. Horne A, Phillips J, Kane N, Lourenco P, McDonald S, Williams A, et al. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS ONE. 2008;3:e3969 pubmed publisher
    ..In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct. The role of the endocannabinoids in tubal implantation in humans is not known...
  90. Al Azemi M, Refaat B, Amer S, Ola B, Chapman N, Ledger W. The expression of inducible nitric oxide synthase in the human fallopian tube during the menstrual cycle and in ectopic pregnancy. Fertil Steril. 2010;94:833-40 pubmed publisher
    ..To investigate the production of inducible nitric oxide synthase (iNOS) in the fallopian tube (FT) during the menstrual cycle and whether epithelia from FTs bearing an ectopic pregnancy differ from healthy tubes in iNOS expression...
  91. Peir R, Herrler A, Santacreu M, Merch n M, Argente M, Garc a M, et al. Expression of progesterone receptor related to the polymorphism in the PGR gene in the rabbit reproductive tract. J Anim Sci. 2010;88:421-7 pubmed publisher
    ..Similar PR-A expression was observed in the ampulla and isthmus; meanwhile, the PR-B expression in the isthmus was double that in the ampulla...
  92. Orihuela P, Zúñiga L, Rios M, Parada Bustamante A, Sierralta W, Velasquez L, et al. Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct. Reprod Biol Endocrinol. 2009;7:139 pubmed publisher
    ..This change was designated as intracellular path shifting (IPS)...