skeletal muscle ventricle

Summary

Summary: Autologous skeletal muscle that is wrapped around the heart and electrically stimulated in order to provide mechanical heart assistance. The latissimus dorsi muscle is commonly used to form this ventricle that functions to independently augment cardiac performance by pumping in series with the heart.

Top Publications

  1. Guldner N, Klapproth P, Grossherr M, Stephan M, Noel R, Sievers H. Operative procedure and volumetry in experimental biomechanical hearts. Thorac Cardiovasc Surg. 2002;50:82-6 pubmed
    ..This indicates that the two-step procedure may be exchanged for a clinically favorable one-step operation. The stroke volume is tested intra-operatively...
  2. Katircioglu S, Ulus A, Saritaş Z, Kaplan S, Tutun U, Aksoyek A, et al. Contractile response of different segments of the latissimus dorsi muscle to chronic stimulation. Jpn J Thorac Cardiovasc Surg. 2003;51:344-8 pubmed
    ..This study was planned to investigate if there is any difference in terms of the muscle force between the distal and proximal segments of the latissimus dorsi muscle...
  3. Thomas G, Baciewicz F, Hammond R, Greer K, Lu H, Bastion S, et al. Power output of pericardium-lined skeletal muscle ventricles, left ventricular apex to aorta configuration: up to eight months in circulation. J Thorac Cardiovasc Surg. 1998;116:1029-42 pubmed
    The purpose of this experiment was to evaluate the potential for a skeletal muscle ventricle connected to the circulation between the left ventricle and the aorta to provide effective, long-term cardiac assist.
  4. Gustafson K, Sweeney J, Gibney J, Fiebig Mathine L. Skeletal muscle ventricle pressure-volume properties conform to dynamic and static conditioning. Ann Thorac Surg. 2003;76:828-35; discussion 835 pubmed
    Chronic changes in skeletal muscle ventricle (SMV) size and strength can directly affect performance and stability. These changes may depend on the conditioning protocol or implant system...
  5. Sevick M, Magovern J, Kamlet M, Rawson I, McCall M, Locke C. Health-related physical function and quality of well-being prior to and following cardiomyoplasty. A preliminary report. Panminerva Med. 1998;40:8-12 pubmed
    ..The purpose of this study was to obtain preliminary data regarding the effects of cardiomyoplasty on health-related physical function and quality of well-being...
  6. Salmons S. Permanent cardiac assistance from skeletal muscle: a prospect for the new millennium. Artif Organs. 1999;23:380-7 pubmed
    ..The current status of the main biological approaches, cardiomyoplasty, aortomyoplasty, and the skeletal muscle ventricle, are discussed, followed by a consideration of some of the important basic issues that need to be ..
  7. Zakine G, Martinod E, Fornes P, Sapoval M, Barritault D, Carpentier A, et al. Growth factors improve latissimus dorsi muscle vascularization and trophicity after cardiomyoplasty. Ann Thorac Surg. 2003;75:549-54 pubmed
    ..In the current study, we hypothesized that local administration of growth factors at the LDM/epicardial interface could improve muscle vascularization and trophicity...
  8. Mesana T, Ferzoco S, Reul R, Sayeed Shah U, Karamichalis J, Laurence R, et al. Innovative techniques in skeletal muscle cardiac assistance: first experimental study on minimally invasive aortomyoplasty and cardiomyoplasty. ASAIO J. 1997;43:M791-6 pubmed
    ..This study suggests future clinical applicability...
  9. Dumcius A, Vysockas V, Chekanov V. [The hemodynamic and myostimulation regimens parallels of the extraaortic counterpulsation and skeletal ventricle in the experiment]. Medicina (Kaunas). 2004;40 Suppl 1:39-43 pubmed
    ..Our investigation was aimed to evaluate the effect of extraaortic counterpulsation to central hemodynamics during the two modes of latissimus dorsi muscle electrostimulation...

More Information

Publications56

  1. Radermecker M, Defraigne J, Limet R. [Cardiac assistance using transformed striated skeletal muscle: cardiomyoplasty]. Rev Med Liege. 1998;53:88-90 pubmed
    ..It is only if an efficient autologous engine is available that optimal surgical configuration (i.e. aortomyoplasty) will provide active cardiocirculatory support...
  2. Greer K, Lu H, Hammond R, Bastian S, Vanderheide R, Stephenson L. Skeletal muscle ventricles: full versus half aortic ligation. J Card Surg. 1998;13:242-51 pubmed
    ..Construction has included full ligation of the thoracic aorta. The authors sought to determine if these muscle pumps could function effectively without fully ligating the aorta...
  3. Misawa Y, Fuse K, Hasegawa T, Konishi H. Growth potential and left ventricular diastolic function in cardiomyoplasty. Ann Thorac Surg. 1998;65:1288-90 pubmed
    ..Current clinical results bring the possibility of its application to children. This study was designed to obtain information about the relationship between cardiomyoplasty and growth of the heart...
  4. Rigatelli G, Barbiero M, Rigatelli G, Riccardi R, Cobelli F, Cotogni A, et al. Maintained benefits and improved survival of dynamic cardiomyoplasty by activity-rest stimulation: 5-year results of the Italian trial on "demand" dynamic cardiomyoplasty. Eur J Cardiothorac Surg. 2003;23:81-5 pubmed
    ..The aim of this work is to report the results at 5 years of follow-up of the Italian Trial of Demand Dynamic Cardiomyoplasty and to discuss their impact on the destiny of this type of cardiac assistance...
  5. Barron D, Etherington P, Winlove C, Jarvis J, Salmons S, Pepper J. Combination of preconditioning and delayed flap elevation: evidence for improved perfusion and oxygenation of the latissimus dorsi muscle for cardiomyoplasty. Ann Thorac Surg. 2001;71:852-61 pubmed
    ..In this study we examined the role of two-staged mobilization and of preconditioning by electrical stimulation on the regional perfusion and oxygenation of the LDM...
  6. Salmons S, Greer K, Shortland A, Jarvis J, Lu H, Bastian S, et al. Skeletal muscle ventricles with a single-limb conduit: the importance of hemodynamic design. J Card Surg. 2004;19:119-27 pubmed
    ..Here we evaluate an alternative approach in which connection to the aorta is made by a single-limb conduit...
  7. Wright L, Zhang K, McClain L, Hsia P, Briggs F, Spratt J. Salbutamol and the conditioning of latissimus dorsi for cardiomyoplasty. J Surg Res. 1999;81:209-15 pubmed
    ..In this study we assessed the effect of salbutamol, a beta2-agonist, on both the positive and the negative effects of conditioning...
  8. Matsubara S, Kitaguchi T. Pathological changes of the myonuclear fibrous lamina and internal nuclear membrane in two cases of autosomal dominant limb-girdle muscular dystrophy with atrioventricular conduction disturbance (LGMD1B). Acta Neuropathol. 2004;107:111-8 pubmed
    ..Furthermore, under an electron microscope, the nuclear fibrous lamina and inner nuclear membrane were relatively indistinct compared to controls. These changes in the myonuclei may be related to pathomechanisms of the present cases...
  9. Trumble D, Magovern J. Capturing in situ skeletal muscle power for circulatory support: a new approach to device design. ASAIO J. 2003;49:480-5 pubmed
    ..9 J/stroke at 60% efficiency. In vitro tests also confirm that key device performance parameters can be computed from pressure readings transmitted via radiotelemetry, clearing the way for long-term implant studies in conscious animals...
  10. Carraro U, Barbiero M, Docali G, Cotogni A, Rigatelli G, Casarotto D, et al. Demand dynamic cardiomyoplasty: mechanograms prove incomplete transformation of the rested latissimus dorsi. Ann Thorac Surg. 2000;70:67-73 pubmed
  11. Dumcius A, Bavarskis E, Chekanov V, Vysockas V. [Testing of the latissimus dorsi muscle stimulation regimens in the experimental model of thoracic aortomyoplasty]. Medicina (Kaunas). 2002;38 Suppl 2:226-9 pubmed
    ..Our investigation was aimed to study two different regimens of latissimus dorsi muscle electrostimulation in acute thoracic aortomyoplasty...
  12. Melvin D, Glos D, Abiog M, Litsky A. Coupling of skeletal muscle to a prosthesis for circulatory support. ASAIO J. 1997;43:M434-41 pubmed
    ..065, t-test); highest estimated requirement was 17.2 N. Interface strength was adequate by 30 days. Continued investigations, addressing other questions, are warranted...
  13. Mott B, Oh J, Misawa Y, Helou J, Badhwar V, Francischelli D, et al. Mechanisms of cardiomyoplasty: comparative effects of adynamic versus dynamic cardiomyoplasty. Ann Thorac Surg. 1998;65:1039-44; discussion 1044-5 pubmed
    ..The purpose of this study was to compare the relative role of the passive "girdling effect" and the dynamic "systolic squeezing effect" of the wrapped muscle in cardiomyoplasty...
  14. Klapproth P, Guldner N, Sievers H. Stroke volume validation and energy evaluation for the dynamic training of skeletal muscle ventricles. Int J Artif Organs. 1997;20:580-8 pubmed
    ..This method offers a simple, reliable and practical procedure to quantify the dynamic training of skeletal muscle ventricles for use in cardiac assistance...
  15. Minoura T, Mizuhara H, Tsutsumi S, Nishimura K, Ban T. A computer simulation study of isometric contraction of latissimus dorsi muscle used for cardiac assistance. ASAIO J. 1997;43:M781-6 pubmed
  16. Ali A, Chiang B, Santamore W, Dowling R, Slater A. Preconditioning of the latissimus dorsi muscle in cardiomyoplasty: vascular delay or chronic electrical stimulation. Eur J Cardiothorac Surg. 1998;14:304-10 pubmed
    ..We hypothesized that latissimus dorsi preconditioning by vascular delay or by chronic electrical stimulation would result in an improved LV hemodynamic function early (14 days) after CMP...
  17. Hagege A, Scorsin M, Samuel J, Rappaport L, Menasche P. [Cellular cardiomyoplasty: state of the art, evaluation, and future possibilities]. Arch Mal Coeur Vaiss. 1998;91:1429-35 pubmed
    ..Therefore, auto-transplantation either of cardiomycocytes obtained by endomyocardial biopsy or of adult skeletal muscle, could be a potential clinical option...
  18. Thompson D, Cmolik B, Cheever E, Geha A, George D. Optimizing muscle-to-cardiac timing for aortomyoplasty. Biomed Sci Instrum. 1997;33:486-90 pubmed
    ..Muscle-to-cardiac timing influences the effectiveness of counterpulsation during aortomyoplasty...
  19. Vural K, Tasdemir O, Küçükaksu S, Tarcan O, Bayazit K. Optimization of synchronization delay in latissimus dorsi dynamic cardiomyoplasty. Ann Thorac Surg. 1998;65:1231-4 pubmed
    ..We investigated the effect of shortening or prolonging the delay time on cardiac functions...
  20. Sharif Z, Hammond R, McDonald P, Vander Heide R, Stephenson L. The functional and histological effects of clenbuterol on the canine skeletal muscle ventricle. J Surg Res. 2005;123:89-95 pubmed
    ..We investigated the anabolic effects of the sympatho-mimetic drug clenbuterol upon pumping chambers constructed from latissimus dorsi muscle (LDM)...
  21. Gustafson K, Sweeney J, Gibney J, Fiebig Mathine L. Is skeletal muscle ventricle chronic stability dependent on wall stress? Design implications. Artif Organs. 2006;30:29-34 pubmed
    Chronic skeletal muscle ventricle (SMV) stability is essential for clinical implementation. SMVs in animal models have chronically expanded or collapsed when exposed to physiologic pressures...
  22. Guldner N, Klapproth P, Grossherr M, Brügge A, Sheikhzadeh A, Tolg R, et al. Biomechanical hearts: muscular blood pumps, performed in a 1-step operation, and trained under support of clenbuterol. Circulation. 2001;104:717-22 pubmed
    ..SMVs without clenbuterol administration failed. Thus, we expected that clenbuterol-supported SMVs might become integrated into the circulation by a 1-step operation instead of the 2-step procedure required up to now...
  23. Woo E, Jarvis J, Hooper T, Salmons S. Avoiding ischemia in latissimus dorsi muscle grafts: electrical prestimulation versus vascular delay. Ann Thorac Surg. 2002;73:1927-32 pubmed
    ..We compared the effectiveness of two procedures designed to maintain blood flow throughout the mobilized muscle...
  24. Rigatelli G, Carraro U, Barbiero M, Riccardi R, Cobelli F, Gemelli M, et al. A review of the concept of circulatory bioassist focused on the "new" demand dynamic cardiomyoplasty: the renewal of dynamic cardiomyoplasty?. Angiology. 2003;54:301-6 pubmed
    ..In developing countries the more economic demand dynamic cardiomyoplasty may still play a role...
  25. Salmons S. Cardiac assistance from skeletal muscle: a reappraisal. Eur J Cardiothorac Surg. 2009;35:204-13 pubmed publisher
    ..Systematic progress has been made over the last 25 years in understanding the relevant basic science. In the light of these advances we should be reconsidering the place of skeletal muscle assist in the surgical armamentarium...
  26. Geddes L. The paradox in using electrically stimulated skeletal muscle to pump blood. Pacing Clin Electrophysiol. 1997;20:1993-2002 pubmed
    ..However, the high preload is only required just before muscle contraction. Two methods are described to attain the high preload and high muscle capillary blood flow...
  27. Bolotin G, Lorusso R, Schreuder J, Kaulbach H, Uretzky G, van der Veen F. Effects of acute dynamic cardiomyoplasty in a goat model of chronic ventricular dilatation: part 1. Ann Thorac Surg. 2002;74:507-13 pubmed
    ..Therefore, a model of chronic left ventricular (LV) dilatation was created to accurately determine actual changes shortly after passive and active wrapped skeletal muscle...
  28. Hishigaki H, Kuhara S. hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds. Database (Oxford). 2011;2011:bar017 pubmed publisher
    ..Database URL: http://www.grt.kyushu-u.ac.jp/hergapdbase/...
  29. Reichenbach S, Farrar D, Diao E, Hill J. In vivo studies of an implantable energy convertor for skeletal muscle powered cardiac assist. ASAIO J. 1997;43:M668-72 pubmed
    ..These initial results are very promising and suggest an implantable energy convertor is feasible. Development of an energy convertor is an important step toward tether-free skeletal muscle powered cardiac assist devices...
  30. Chiang B, Ali A, Unger L, Slater A, Santamore W. Cardiomyoplasty: hemodynamic benefit to normal and depressed canine left ventricular function. ASAIO J. 1997;43:M786-90 pubmed
    ..Thus, investigations of cardiomyoplasty may not necessarily require a model of severe myocardial dysfunction. Vascular delay offers an important preconditioning method of LDM to augment cardiac function in cardiomyoplasty...
  31. Thompson D, Michele J, Cheever E, George D. Selective stimulation of latissimus dorsi muscle for cardiac assist. Ann Biomed Eng. 1999;27:48-55 pubmed
    ..05). Selective activation of LDM is possible with little or no functional overlap; however, the muscle regions were nonuniform. Selective stimulation may ultimately facilitate the use of performance enhancing stimulus protocols for SMCA...
  32. Grubb N, Van Doorn C, Sutherland G, Fox K, Hooper T. Assessment of skeletal muscle ventricle function using tissue velocity imaging. J Card Surg. 1997;12:420-30 pubmed
  33. Lorusso R, Alfieri O, Carraro U, Schreuder J, Wellens H. Preserved skeletal muscle structure with modified electrical stimulation protocol in a cardiomyoplasty patient: a clinico-pathological report. Eur J Cardiothorac Surg. 1998;13:213-5 pubmed
    ..After unexpected sudden death occurred at 15 months, autoptic examination showed preserved muscle structure, suggesting that a prudent stimulation protocol may maintain muscle viability and contribute to effective cardiac support...
  34. Abidov A, Stewart J, Raff G. Muscular ventricular septal defect visualized as nonreversible perfusion abnormality on myocardial perfusion SPECT and confirmed on cardiac computed tomography angiography images. Clin Nucl Med. 2009;34:171-2 pubmed publisher
    ..The presence of the ventricular septal defect should be considered in differential diagnosis of an isolated fixed septal perfusion abnormality on SPECT images in patients with no history of prior MI...
  35. Barron D, Etherington P, Winlove C, Jarvis J, Salmons S, Pepper J. Muscle transformation in cardiomyoplasty: the effect of conditioning and mobilisation on perfusion, oxygenation and fatigue resistance in the latissimus dorsi muscle. Eur J Cardiothorac Surg. 1998;13:588-98 pubmed
    ..Possible causes are ischaemia and degeneration related to the conditioning process. We studied the nutritional and structural changes occurring under different stimulation regimes with the aim of improving the conditioning protocol...
  36. Shortland A, Jarvis J, Salmons S. Haemodynamic considerations in the design of a skeletal muscle ventricle. Med Biol Eng Comput. 2003;41:529-35 pubmed
    ..At elective termination 1 week later, activation of the SMV increased peak diastolic pressure by 20.1% and reduced left-ventricular stroke work in the post-assisted beat by 10.1%. The SMV was free from thrombus...
  37. Kawaguchi O, Huang Y, Yuasa T, Horam C, Carrington R, Biao Z, et al. Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship. J Thorac Cardiovasc Surg. 1998;115:1358-66 pubmed
    ..We therefore evaluated the efficiency of energy transfer from the native pressure-volume area to external work under conditions of 1:3 skeletal muscle burst pacing in an animal model with chronic heart failure...
  38. Badhwar V, Badhwar R, Oh J, Chiu R. Power generation from four skeletal muscle configurations. Design implications for a muscle powered cardiac assist device. ASAIO J. 1997;43:M651-7 pubmed
    ..a latex compliance chamber placed between the LDM and chest wall (Sub-Dorsi), a chamber wrapped in a skeletal muscle ventricle (Circular), linear measurements from the thoracolumbar origin (Linear Origin), and linear measurements ..
  39. Monchamp T, Frishman W. Exercise as a treatment modality for congestive heart failure. Heart Dis. 2002;4:110-6 pubmed
    ..This article reviews the current experience with exercise and congestive heart failure and discusses strategies used to implement an exercise program for patients...
  40. de Angelis K, Senna S, Irigoyen M, Cestari I. Diabetes-induced alterations in latissimus dorsi muscle properties impair effectiveness of dynamic cardiomyoplasty in rats. Artif Organs. 2004;28:326-31 pubmed
    ..The marked decrease in CDM effectiveness in diabetic rats likely reflected the alterations in muscle properties associated with diabetes...
  41. Melvin D, Klosterman B, Gramza B, Byrne M, Weisbrode S, Litsky A, et al. A durable load bearing muscle to prosthetic coupling. ASAIO J. 2003;49:314-9 pubmed
    ..These findings support the aggressive pursuit of muscle powered mechanisms for artificial hearts, assist devices, and heart wall actuators...
  42. Singh T, Greer K, Muzik O, Hammond R, Stephenson L, Di Carli M. Assessment of skeletal muscle ventricle tissue blood flow using positron emission tomography. Artif Organs. 2001;25:306-12 pubmed
    ..assessed the feasibility of using positron emission tomography (PET) imaging for in vivo measurement of skeletal muscle ventricle (SMV) tissue blood flow...
  43. Radermecker M, Chaussende F, Struble C, Grandjean P, Fourny J, Focant B, et al. Biomechanical characteristics of unconditioned and conditioned latissimus dorsi muscles used for cardiocirculatory assistance. Cardiovasc Surg. 1997;5:516-25 pubmed
    ..The residual power output did not, however, preclude the possibility of a significant cardiocirculatory contribution, providing that the conditions for optimal energy transduction are adequately delineated...
  44. Chiang B, Ali A, Storey J, Riordan C, Ballen J, Montgomery W, et al. Variable effects of cardiomyoplasty on left ventricular function. Artif Organs. 1997;21:1277-83 pubmed
    ..The integrity of the LDM, tightness of wrapping, and adhesions might contribute to the variability which is present early after surgery and before the LDM is converted into a fatigue resistance muscle...
  45. Lanmuller H, Girsch W, Rab M, Sauermann S, Kamolz L, Seitelberger R, et al. Preparation of a skeletal muscle ventricle in sheep: severe damage to the Latissimus dorsi muscle due to mobilization before preconditioning. Eur Surg Res. 2000;32:129-34 pubmed
    As part of a study examining the use of a skeletal muscle ventricle for cardiac assistance in sheep, a new concept of muscle preconditioning was put into practice...
  46. Chekanov V, Tchekanov G, Rieder M, Hare J, Mortada M. Effects of electrical stimulation postcardiomyoplasty in a model of chronic heart failure: hemodynamic results after daily 12-hour cessation versus a nonstop regimen. Pacing Clin Electrophysiol. 2000;23:1094-102 pubmed
    ..Because hemodynamic results do not seem to be impaired, we recommend daily, periodic cessation of stimulation to prevent damage to the LDM after CMP...
  47. Gutierrez P, Pires W, Marie S, Moreira L, Mady C, Higuchi M, et al. Histopathological findings in skeletal muscle used in human dynamic cardiomyoplasty. J Pathol. 2001;194:116-21 pubmed
    ..These findings could play a role in explaining the long-term results of this surgical procedure...