chorionic villi

Summary

Summary: Threadlike vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).

Top Publications

  1. Baczyk D, Dunk C, Huppertz B, Maxwell C, Reister F, Giannoulias D, et al. Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi. Placenta. 2006;27:367-74 pubmed
    ..EVT) cells invade the uterine wall to promote maternal blood flow whilst syncytiotrophoblast lines chorionic villi in the labyrinth...
  2. Mori M, Ishikawa G, Luo S, Mishima T, Goto T, Robinson J, et al. The cytotrophoblast layer of human chorionic villi becomes thinner but maintains its structural integrity during gestation. Biol Reprod. 2007;76:164-72 pubmed
    b>Chorionic villi in the human placenta serve as essential structures in fetomaternal exchanges...
  3. Duaso J, Rojo G, Cabrera G, Galanti N, Bosco C, Maya J, et al. Trypanosoma cruzi induces tissue disorganization and destruction of chorionic villi in an ex vivo infection model of human placenta. Placenta. 2010;31:705-11 pubmed publisher
    ..Infection of the chorionic villi with the parasite was confirmed by immunofluoresence and PCR. T...
  4. Jessmon P, Kilburn B, Romero R, Leach R, Armant D. Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts. Biol Reprod. 2010;82:921-9 pubmed publisher
    ..These experiments reveal a complexity of the intracellular signaling circuitry that regulates trophoblast functions critical for implantation and placentation...
  5. Poloni A, Rosini V, Mondini E, Maurizi G, Mancini S, Discepoli G, et al. Characterization and expansion of mesenchymal progenitor cells from first-trimester chorionic villi of human placenta. Cytotherapy. 2008;10:690-7 pubmed publisher
    ..We report on the isolation, expansion and differentiation in vitro of MSC-like cells from chorionic villi (CV).
  6. Apps R, Sharkey A, Gardner L, Male V, Trotter M, Miller N, et al. Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells. Placenta. 2011;32:33-43 pubmed publisher
    ..Since LAIR-2 is detectable in the urine of pregnant, but not non-pregnant women, trophoblast-derived LAIR-2 may also have systemic effects during pregnancy...
  7. Zhou C, Ahmad S, Mi T, Xia L, Abbasi S, Hewett P, et al. Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circ Res. 2007;100:88-95 pubmed
  8. Morales C, Sanchez A, Bruguera J, Margarit E, Borrell A, Borobio V, et al. Cytogenetic study of spontaneous abortions using semi-direct analysis of chorionic villi samples detects the broadest spectrum of chromosome abnormalities. Am J Med Genet A. 2008;146A:66-70 pubmed
    ..describe the cytogenetic findings in a series of 116 first trimester arrested pregnancies, obtained through chorionic villi sampling (CVS) and semi-direct analysis that avoids some of the long-culture pitfalls such as maternal ..
  9. Anton L, Merrill D, Neves L, Stovall K, Gallagher P, Diz D, et al. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. Hypertension. 2008;51:1066-72 pubmed publisher
    The chorionic villi in the placenta are responsible for the regulation of fetal oxygen and nutrient transport...

More Information

Publications62

  1. Biswas S, Ghosh S, Chhabra S. Surface area of chorionic villi of placentas: an index of intrauterine growth restriction of fetuses. J Obstet Gynaecol Res. 2008;34:487-93 pubmed publisher
    ..IUGR) fetuses as well as normal-weight (control) fetuses were performed to determine surface area of chorionic villi (mostly terminal and few intermediate) using stereological technique...
  2. Abumaree M, Al Jumah M, Kalionis B, Jawdat D, Al Khaldi A, Altalabani A, et al. Phenotypic and functional characterization of mesenchymal stem cells from chorionic villi of human term placenta. Stem Cell Rev. 2013;9:16-31 pubmed publisher
    ..We report a novel method of isolating placental MSCs (pMSCs) from chorionic villi, which exhibit the phenotypic and functional characteristics that will make them an attractive source of MSCs ..
  3. Spitalieri P, Cortese G, Pietropolli A, Filareto A, Dolci S, Klinger F, et al. Identification of multipotent cytotrophoblast cells from human first trimester chorionic villi. Cloning Stem Cells. 2009;11:535-56 pubmed publisher
    ..These cells may be a safe and convenient source of cells for cell-based therapy, as well as an ideal target for in utero fetal gene therapy...
  4. Huisman M, Timmer B, Stegehuis J, Swart B, Aarnoudse J, Erwich J. Vascularization in first-trimester chorionic villi in complicated and uncomplicated pregnancies. Am J Obstet Gynecol. 2010;202:88.e1-7 pubmed publisher
  5. Aplin J, Jones C, Harris L. Adhesion molecules in human trophoblast - a review. I. Villous trophoblast. Placenta. 2009;30:293-8 pubmed publisher
    ..There is a wide gulf to be filled between molecular anatomy and functional studies, with much to be learned about the role of adhesion molecules in regulating villous epithelial integrity, homeostasis and growth...
  6. Poloni A, Maurizi G, Serrani F, Mancini S, Discepoli G, Tranquilli A, et al. Human AB serum for generation of mesenchymal stem cells from human chorionic villi: comparison with other source and other media including platelet lysate. Cell Prolif. 2012;45:66-75 pubmed publisher
    We have investigated foetal mesenchymal stem cells (MSCs) obtained from first-trimester chorionic villi (CV) and second-trimester amniotic fluid (AF), comparing them to adult bone marrow-derived MSCs.
  7. Filges I, Kang A, Klug V, Wenzel F, Heinimann K, Tercanli S, et al. aCGH on chorionic villi mirrors the complexity of fetoplacental mosaicism in prenatal diagnosis. Prenat Diagn. 2011;31:473-8 pubmed publisher
    To describe the diagnostic performance of array comparative genomic hybridization (aCGH) in the presence of mosaicism in the fetoplacental unit using direct chorionic villi.
  8. Duaso J, Rojo G, Jaña F, Galanti N, Cabrera G, Bosco C, et al. Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi. Placenta. 2011;32:356-61 pubmed publisher
    ..In order to determine the effect of parasite invasion on normal apoptosis in the placenta, explants of human chorionic villi were incubated with 105 trypomastigotes for 24 h. Effective infection was tested by visualizing T...
  9. Gurevich P, Elhayany A, Milovanov A, Halperin R, Kaganovsky E, Zusman I, et al. The placental barrier in allogenic immune conflict in spontaneous early abortions: immunohistochemical and morphological study. Am J Reprod Immunol. 2007;58:460-7 pubmed
    ..Morphologic changes in the placental barrier in spontaneous early abortions under the maternal-embryonic immune conflict, and the role of maternal immunoglobulins (Igs) in these changes...
  10. Cindrova Davies T, Spasic Boskovic O, Jauniaux E, Charnock Jones D, Burton G. Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant . Am J Pathol. 2007;170:1511-20 pubmed
    ..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro...
  11. Zhao M, Qiu W, Li Y, Sang Q, Wang Y. Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells. Sci China C Life Sci. 2009;52:710-8 pubmed publisher
    ..These data indicate that ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation...
  12. Poloni A, Maurizi G, Babini L, Serrani F, Berardinelli E, Mancini S, et al. Human mesenchymal stem cells from chorionic villi and amniotic fluid are not susceptible to transformation after extensive in vitro expansion. Cell Transplant. 2011;20:643-54 pubmed publisher
    ..In this study, we characterized human mesenchymal progenitor cells from chorionic villi (CV) and amniotic fluid (AF) isolated during the first and second trimesters, respectively, and compared them ..
  13. Calzarossa C, Bossolasco P, Besana A, Manca M, De Grada L, De Coppi P, et al. Neurorescue effects and stem properties of chorionic villi and amniotic progenitor cells. Neuroscience. 2013;234:158-72 pubmed publisher
  14. Demir R. Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy. Folia Histochem Cytobiol. 2009;47:435-45 pubmed publisher
    ..Probably, this event may be related to complete vasculugenesis and angiogenesis in placental villi...
  15. Castillo C, López Muñoz R, Duaso J, Galanti N, Jaña F, Ferreira J, et al. Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi. Placenta. 2012;33:991-7 pubmed publisher
    ..In the present study we analyzed the participation of matrix metalloproteases (MMPs) in the extracellular matrix (ECM) remodeling during T. cruzi ex vivo infection of human placental chorionic villi explants.
  16. Meng C, Cheng L, Lalitkumar P, Zhang L, Zhang H, Gemzell Danielsson K. Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception. Fertil Steril. 2009;91:1420-3 pubmed publisher
    ..did not affect the immunohistochemical expressions of estrogen receptors (ER(alpha), ER(beta)), P receptors (PR(B), PR(A+B)), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.
  17. Founds S, Conley Y, Lyons Weiler J, Jeyabalan A, Hogge W, Conrad K. Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta. 2009;30:15-24 pubmed publisher
    ..Accordingly, we hypothesized dysregulation of global gene expression in first trimester placentas of women who later manifested preeclampsia...
  18. Pavlov O, Lalayan D, Sel kov S. Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue. Bull Exp Biol Med. 2006;141:720-3 pubmed
    ..The results suggest that cytokine regulation of the fetus rejection is different at early and late stages of gestation...
  19. Castrechini N, Murthi P, Gude N, Erwich J, Gronthos S, Zannettino A, et al. Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta. 2010;31:203-12 pubmed publisher
    The chorionic villi of human term placentae are a rich source of mesenchymal stem cells (PMSCs)...
  20. Vinnars M, Wijnaendts L, Westgren M, Bolte A, Papadogiannakis N, Nasiell J. Severe preeclampsia with and without HELLP differ with regard to placental pathology. Hypertension. 2008;51:1295-9 pubmed publisher
    ..Considering the central role that placenta seems to have in preeclampsia, the present result might suggest that different underlying pathogenetic mechanisms and courses can be in play in patients with preeclampsia and HELLP syndrome...
  21. Founds S, Fallert Junecko B, Reinhart T, Conley Y, Parks W. LAIR2 localizes specifically to sites of extravillous trophoblast invasion. Placenta. 2010;31:880-5 pubmed publisher
    ..Neither the localization nor the function of LAIR2 has been examined in the placenta. Localization studies were conducted in placental tissues to determine the precise sites of LAIR2 mRNA production and protein binding...
  22. Tarrade A, Lai Kuen R, Malassine A, Tricottet V, Blain P, Vidaud M, et al. Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta. Lab Invest. 2001;81:1199-211 pubmed
    ..We report the first isolation and purification of these two cell types from the same chorionic villi of first trimester human placenta. We also studied their differentiation in vitro...
  23. Bukovsky A, Cekanova M, Caudle M, Wimalasena J, Foster J, Keenan J, et al. Variability of placental expression of cyclin E low molecular weight variants. Biol Reprod. 2002;67:568-74 pubmed
    ..However, an enhanced expression of some cyclin E LMW proteins only might reflect an association of cyclin E isoforms with placental aging or an inefficient placental adaptation...
  24. Niers L, van den Heuvel L, Trijbels F, Sengers R, Smeitink J. Prerequisites and strategies for prenatal diagnosis of respiratory chain deficiency in chorionic villi. J Inherit Metab Dis. 2003;26:647-58 pubmed
    ..Prenatal diagnosis currently relies on biochemical assays of respiratory chain complexes in chorionic villi or amniocytes and is possible by mutation analysis of nuclear genes in a limited but increasing proportion of ..
  25. Leach R, Kilburn B, Wang J, Liu Z, Romero R, Armant D. Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev Biol. 2004;266:223-37 pubmed
    ..Addition of HB-EGF during explant culture of first-trimester chorionic villi enhanced extravillous trophoblast differentiation and invasive activity...
  26. Elustondo P, Hannigan G, Caniggia I, Macphee D. Integrin-linked kinase (ILK) is highly expressed in first trimester human chorionic villi and regulates migration of a human cytotrophoblast-derived cell line. Biol Reprod. 2006;74:959-68 pubmed
    ..survival, migration, and invasion; yet the temporal and spatial pattern of expression of ILK in human chorionic villi and its role in early human placental development are completely unknown...
  27. Hung T, Skepper J, Charnock Jones D, Burton G. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002;90:1274-81 pubmed
    ..The quality of placental perfusion may therefore be a more important factor in the pathophysiology of preeclampsia than the absolute quantity...
  28. Malassine A, Cronier L. Hormones and human trophoblast differentiation: a review. Endocrine. 2002;19:3-11 pubmed
  29. Bukovsky A, Cekanova M, Caudle M, Wimalasena J, Foster J, Henley D, et al. Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol. Reprod Biol Endocrinol. 2003;1:13 pubmed
    ..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression...
  30. Chen H, Chao K, Shew J, Yang Y, Ho H. Expression of leukemia inhibitory factor and its receptor is not altered in the decidua and chorionic villi of human anembryonic pregnancy. Hum Reprod. 2004;19:1647-54 pubmed
    ..However LIF is not required for post-implantation development of mouse embryo. The objective of this study was to examine the role of LIF system in post-implantation stage of human pregnancy...
  31. Faye A, Pornprasert S, Dolcini G, Ave P, Taieb J, Taupin J, et al. Evaluation of the placental environment with a new in vitro model of histocultures of early and term placentae: determination of cytokine and chemokine expression profiles. Placenta. 2005;26:262-7 pubmed
    ..These data indicate that placental histoculture is a suitable and reliable in vitro model for studying the placental environment...
  32. Pornprasert S, Faye A, Mary J, Dolcini G, Leechanachai P, Chaouat G, et al. Down modulation of TNF-alpha mRNA placental expression by AZT used for the prevention of HIV-1 mother-to-child transmission. Placenta. 2006;27:989-95 pubmed
    ..To evaluate the effects of AZT on placental cytokine expression, the chorionic villi from HIV-1 uninfected women term placentae were cultured with 0, 100, and 2,000 ng/ml AZT...
  33. Grati F, Grimi B, Frascoli G, Di Meco A, Liuti R, Milani S, et al. Confirmation of mosaicism and uniparental disomy in amniocytes, after detection of mosaic chromosome abnormalities in chorionic villi. Eur J Hum Genet. 2006;14:282-8 pubmed
    Chromosome mosaicism is detected in about 1-2% of chorionic villi samples (CVS), and may be due to a postzygotic nondisjunction event generating a trisomic cell line in an initially normal conceptus (mitotic origin) or the postzygotic ..
  34. Robino C, Barilaro M, Gino S, Chiarle R, Palestro G, Torre C. Incestuous paternity detected by STR-typing of chorionic villi isolated from archival formalin-fixed paraffin-embedded abortion material using laser microdissection. J Forensic Sci. 2006;51:90-2 pubmed
    ..and mentally disabled woman taken to the emergency room because of genital bleeding revealed the presence of chorionic villi encircled by decidua, hemorrhage, and necrosis...
  35. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1085-93 pubmed
    ..Low oxygen levels, as opposed to intermittent oxygen tension (HR) changes, play an important role in regulating sFlt-1 expression in the developing human placenta and hence may contribute to the development of preeclampsia...
  36. Ahmad S, Ahmed A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res. 2004;95:884-91 pubmed
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
  37. Bauer S, Pollheimer J, Hartmann J, Husslein P, Aplin J, Knöfler M. Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab. 2004;89:812-22 pubmed
    ..Induction of PAI-1 by TNF alpha could be related to restricted trophoblast invasion in preeclampsia...
  38. Sartori M, Pons P, Mezzano L, Lin S, de Fabro S. Trypanosoma cruzi infection induces microfilament depletion in human placenta syncytiotrophoblast. Placenta. 2003;24:767-71 pubmed
    ..The recruitment of lysosomes occurs directly beneath the invasion site, and this process is required for parasite internalization...
  39. Cronier L, Frendo J, Defamie N, Pidoux G, Bertin G, Guibourdenche J, et al. Requirement of gap junctional intercellular communication for human villous trophoblast differentiation. Biol Reprod. 2003;69:1472-80 pubmed
    ..These data suggest that the molecular exchanges through gap junctions preceding cellular fusion are essential for trophoblast differentiation generating the multifunctional syncytiotrophoblast...
  40. Lash G, McLaughlin B, MacDonald Goodfellow S, Smith G, Brien J, Marks G, et al. Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta. Am J Physiol Heart Circ Physiol. 2003;284:H160-7 pubmed
    ..Compared with microsomes isolated from morphologically normal and peri-infarct chorionic villi of pathological placentas, microsomes from infarcted chorionic villi from the same placentas had decreased HO ..
  41. Simán C, Sibley C, Jones C, Turner M, Greenwood S. The functional regeneration of syncytiotrophoblast in cultured explants of term placenta. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1116-22 pubmed
    ..This culture system provides opportunities for studies of chronic regulation of placental function...
  42. Chen H, Chen J, Tzeng C, Li H, Chang S, Cheng Y, et al. Global analysis of differentially expressed genes in early gestational decidua and chorionic villi using a 9600 human cDNA microarray. Mol Hum Reprod. 2002;8:475-84 pubmed
    The global gene expression profiles of the decidua and chorionic villi of early human pregnancies were analysed by using cDNA microarray technology...
  43. Los F, van Den Berg C, Wildschut H, Brandenburg H, Den Hollander N, Schoonderwaldt E, et al. The diagnostic performance of cytogenetic investigation in amniotic fluid cells and chorionic villi. Prenat Diagn. 2001;21:1150-8 pubmed
    ..a difference in the diagnostic performances of cytogenetic investigation in amniotic fluid (AF) cells and chorionic villi in favour of AF-cells might justify this...
  44. Rajashekhar G, Loganath A, Roy A, Wong Y. Expression and localization of angiogenin in placenta: enhanced levels at term over first trimester villi. Mol Reprod Dev. 2002;62:159-66 pubmed
    ..Placental growth requires extensive angiogenesis, which develops its vascular structure in both fetal chorionic villi and maternal deciduas...
  45. Yu X, Wang L, Yan C, Li X. Expression and localization of tumor necrosis factor receptor 1 protein in the chorionic villi in early normal and spontaneous abortion. Eur J Obstet Gynecol Reprod Biol. 2007;132:58-63 pubmed
    ..Here we compare membrane TNFR1 (mTNFR1) protein expression on chorionic villi in women with spontaneous abortion (SA) and viable pregnancy.
  46. Kniss D, Xie Y, Li Y, Kumar S, Linton E, Cohen P, et al. ED(27) trophoblast-like cells isolated from first-trimester chorionic villi are genetically identical to HeLa cells yet exhibit a distinct phenotype. Placenta. 2002;23:32-43 pubmed
    ..These results point out the need for adherence to rigorous and consistent quality control measures to assure the authenticity of cell lines used as in vitro model systems...
  47. Cross J, Nakano H, Natale D, Simmons D, Watson E. Branching morphogenesis during development of placental villi. Differentiation. 2006;74:393-401 pubmed
  48. Kfutwah A, Mary J, Nicola M, Blaise Boisseau S, Barré Sinoussi F, Ayouba A, et al. Tumour necrosis factor-alpha stimulates HIV-1 replication in single-cycle infection of human term placental villi fragments in a time, viral dose and envelope dependent manner. Retrovirology. 2006;3:36 pubmed
    ..Proinflammatory cytokines in the placental environment are particularly implicated in this control. We thus investigated the effect of TNF-alpha on HIV-1 expression in human placental tissues in vitro...
  49. Zhang X, Mitsuru A, Igura K, Takahashi K, Ichinose S, Yamaguchi S, et al. Mesenchymal progenitor cells derived from chorionic villi of human placenta for cartilage tissue engineering. Biochem Biophys Res Commun. 2006;340:944-52 pubmed
    ..The results of these in vivo and in vitro studies suggested that hPDMCs can be one of the possible allogeneic cell sources for tissue engineering of cartilage...
  50. Ahmed H, McLaughlin B, Soong J, Marks G, Brien J, Nakatsu K. The source of endogenous carbon monoxide formation in human placental chorionic villi. Cell Mol Biol (Noisy-le-grand). 2005;51:447-51 pubmed
    ..Human placental cotyledons were perfused with Kreb s solution to remove blood. Chorionic villi segments were prepared for measurements of CO production in the absence/presence of an exogenous supply of ..
  51. Even Ram S, Grisaru Granovsky S, Pruss D, Maoz M, Salah Z, Yong Jun Y, et al. The pattern of expression of protease-activated receptors (PARs) during early trophoblast development. J Pathol. 2003;200:47-52 pubmed
    ..Together, our data suggest the involvement of PAR1 and PAR3 in restricted and unrestricted pathological trophoblast invasion...
  52. Willemsen R, Bontekoe C, Severijnen L, Oostra B. Timing of the absence of FMR1 expression in full mutation chorionic villi. Hum Genet. 2002;110:601-5 pubmed
    ..Prenatal diagnosis can be performed on chorionic villi samples (CVS) by Southern blot analysis...
  53. Fievet N, Moussa M, Tami G, Maubert B, Cot M, Deloron P, et al. Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta. J Infect Dis. 2001;183:1530-4 pubmed
    ..This study measured cytokines secreted in cultures of chorionic villi, placental blood cells (PBC), and serum in term placentas from 88 malaria-infected and -noninfected Cameroon ..