chorion

Summary

Summary: The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.

Top Publications

  1. Li J, Kim S, Li J. Molecular characterization of a novel peroxidase involved in Aedes aegypti chorion protein crosslinking. Insect Biochem Mol Biol. 2004;34:1195-203 pubmed
    Peroxidase-catalyzed chorion or eggshell protein crosslinking is an important biochemical event contributing to the formation of a protective chorion or eggshell in insects...
  2. Kim M, Shin K, Jeon J, Lee D, Shim S, Kim J, et al. Human chorionic-plate-derived mesenchymal stem cells and Wharton's jelly-derived mesenchymal stem cells: a comparative analysis of their potential as placenta-derived stem cells. Cell Tissue Res. 2011;346:53-64 pubmed publisher
    ..Thus, we propose that CP-MSCs and WJ-MSCs are useful sources of cells for appropriate clinical applications in the treatment of various degenerative diseases...
  3. Papantonis A, Vanden Broeck J, Lecanidou R. Architectural factor HMGA induces promoter bending and recruits C/EBP and GATA during silkmoth chorion gene regulation. Biochem J. 2008;416:85-97 pubmed publisher
    ..This factor, named BmHMGA, exhibits specific binding preference for chorion gene promoter elements and induces DNA bending thereon...
  4. Koob T, Rennert R, Zabek N, Massee M, Lim J, Temenoff J, et al. Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int Wound J. 2013;10:493-500 pubmed publisher
    Human amnion/chorion tissue derived from the placenta is rich in cytokines and growth factors known to promote wound healing; however, preservation of the biological activities of therapeutic allografts during processing remains a ..
  5. Barcena A, Muench M, Kapidzic M, Gormley M, Goldfien G, Fisher S. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011;51 Suppl 4:94S-105S pubmed publisher
  6. Yoshino Y, Yuan B, Kaise T, Takeichi M, Tanaka S, Hirano T, et al. Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes. Toxicol Appl Pharmacol. 2011;257:198-208 pubmed publisher
    ..We examined the effects of As(III) on primary cultured chorion (C) and amnion (A) cells prepared from human fetal membranes...
  7. Mills T, Baker P, Wareing M. The effect of mode of delivery on placental chorionic plate vascular reactivity. Hypertens Pregnancy. 2007;26:201-10 pubmed
    ..To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity...
  8. Yang I, Lee D, Lee S, Kang J. Characterization of proteolytically digested zebrafish chorion as extracellular matrix. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1837-40 pubmed publisher
    ..Here we report new ECM like biomaterials, pFZC, obtained from the fertilized Zebrafish chorion (FZC). pFZC was prepared by digesting the fertilized Zebrafish chorion with pronase...
  9. Li J, Li J. Major chorion proteins and their crosslinking during chorion hardening in Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2006;36:954-64 pubmed
    The chorion of Aedes aegypti eggs undergoes a hardening process following oviposition and individual chorion proteins become insoluble thereafter...

More Information

Publications62

  1. Uchide N, Ohyama K, Bessho T, Toyoda H. Effects of mitogen-activated protein kinase inhibitors on tumor necrosis factor-alpha gene expression and apoptosis induction in cultured human fetal membrane chorion cells infected with influenza virus. Intervirology. 2007;50:99-107 pubmed
    ..the involvement of p38 mitogen-activated protein (MAP) kinase in tumor necrosis factor (TNF)-alpha gene expression, apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus.
  2. Calvin S, Oyen M. Microstructure and mechanics of the chorioamnion membrane with an emphasis on fracture properties. Ann N Y Acad Sci. 2007;1101:166-85 pubmed
    ..The amnion and the chorion, separately and together as the bilayer chorioamnion, serve barrier and container functions throughout gestation, ..
  3. Sweeney M, Wareing M, Mills T, Baker P, Taggart M. Characterisation of tone oscillations in placental and myometrial arteries from normal pregnancies and those complicated by pre-eclampsia and growth restriction. Placenta. 2008;29:356-65 pubmed publisher
    ..The alterations may contribute to the vasculopathology of these conditions, or, may represent compensatory mechanisms to maintain a matching of materno-placental blood flow...
  4. Mohr S, Portmann Lanz C, Schoeberlein A, Sager R, Surbek D. Generation of an osteogenic graft from human placenta and placenta-derived mesenchymal stem cells. Reprod Sci. 2010;17:1006-15 pubmed publisher
    ..Initially, a scaffold from human chorion membrane was produced...
  5. Skrzypczak J, Jasinski P, Wirstlein P, Gozdziewicz T, Rajewski M. [Histologic changes in placenta and chorion of women with antiphospholipid syndrome and inherited thrombophilia]. Ginekol Pol. 2011;82:652-63 pubmed
  6. Grigsby P, Novy M, Adams Waldorf K, Sadowsky D, Gravett M. Choriodecidual inflammation: a harbinger of the preterm labor syndrome. Reprod Sci. 2010;17:85-94 pubmed publisher
    ..varying doses of a clinical isolate of GBS, type III or saline, via an indwelling catheter placed between the chorion/decidua and myometrium in the lower pole of the uterus...
  7. Simmons D, Natale D, Begay V, Hughes M, Leutz A, Cross J. Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development. 2008;135:2083-91 pubmed publisher
    ..These genes were also expressed in distinct layers in the chorion as early as E8.5, prior to villous formation...
  8. George R, Kalich J, Yonish B, Murtha A. Apoptosis in the chorion of fetal membranes in preterm premature rupture of membranes. Am J Perinatol. 2008;25:29-32 pubmed
    We sought to determine if apoptosis in the chorion of fetal membranes was increased in patients with preterm premature rupture of membranes (PPROM) with histological chorioamnionitis...
  9. Witkowska Zimny M, Wrobel E. Perinatal sources of mesenchymal stem cells: Wharton's jelly, amnion and chorion. Cell Mol Biol Lett. 2011;16:493-514 pubmed publisher
    ..This review highlights the characteristics and therapeutic potential of three human mesenchymal stem cell types obtained from perinatal sources: Wharton's jelly, the amnion, and the chorion.
  10. Canzoneri B, Feng L, Grotegut C, Bentley R, Heine R, Murtha A. The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. Reprod Sci. 2013;20:1246-54 pubmed publisher
    ..We tested the hypothesis that PPROM is the result of tissue remodeling in the fetal membranes, specifically the chorion, and this weakening of the chorion compromises the protection provided to the amnion...
  11. Klein C, Strobel J, Zingsem J, Richter R, Goecke T, Beckmann M, et al. Ex vivo expansion of hematopoietic stem- and progenitor cells from cord blood in coculture with mesenchymal stroma cells from amnion, chorion, Wharton's jelly, amniotic fluid, cord blood, and bone marrow. Tissue Eng Part A. 2013;19:2577-85 pubmed publisher
    ..and increases the risk of transmissible infectious diseases for the patient can be replaced by MSCs from amnion, chorion, Wharton's jelly, amniotic fluid, and CB, which can be isolated from placental tissue which is readily available ..
  12. Parolini O, Alviano F, Bagnara G, Bilic G, Buhring H, Evangelista M, et al. Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells. 2008;26:300-11 pubmed
  13. Okamoto K, Miyoshi S, Toyoda M, Hida N, Ikegami Y, Makino H, et al. 'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells. Exp Cell Res. 2007;313:2550-62 pubmed
    ..Placenta-derived human fetal cells may be useful for patients who cannot supply bone marrow cells but want to receive stem cell-based cardiac therapy...
  14. Yuan B, Ohyama K, Bessho T, Uchide N, Toyoda H. Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissues. Life Sci. 2008;82:623-30 pubmed publisher
    We have previously demonstrated that induction of apoptosis was observed in the smooth chorion trophoblast cells of human fetal membranes prepared at term, and that apoptosis progressed rapidly during in vitro incubation of the tissues...
  15. Gao L, He P, Sha J, Liu C, Dai L, Hui N, et al. Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. Endocrinology. 2007;148:3645-54 pubmed
    Throughout gestation, the chorion laeve controls the levels of biologically active prostaglandins (PGs) by its high level of nicotinamide adenine dinucleotide-dependent 15-hydroxy PG dehydrogenase (PGDH)...
  16. Genbacev O, Donne M, Kapidzic M, Gormley M, Lamb J, Gilmore J, et al. Establishment of human trophoblast progenitor cell lines from the chorion. Stem Cells. 2011;29:1427-36 pubmed publisher
    ..This finding suggested that the human placenta has another progenitor niche. Here, we show that the chorion is one such site...
  17. Doberenz J, Birkenfeld C, Kluge H, Eder K. Effects of L-carnitine supplementation in pregnant sows on plasma concentrations of insulin-like growth factors, various hormones and metabolites and chorion characteristics. J Anim Physiol Anim Nutr (Berl). 2006;90:487-99 pubmed
    ..This in turn may enhance development of the placentae and the intrauterine nutrition of the fetuses. This may be the reason for increased birth weights observed in recent studies in sows supplemented with L-carnitine...
  18. Kais B, Schneider K, Keiter S, Henn K, Ackermann C, Braunbeck T. DMSO modifies the permeability of the zebrafish (Danio rerio) chorion-implications for the fish embryo test (FET). Aquat Toxicol. 2013;140-141:229-38 pubmed publisher
    ..of DMSO, the impact of different concentrations of DMSO on the potential barrier function of the zebrafish chorion and on changes in the uptake of chemicals into the embryo...
  19. Bačenková D, Rosocha J, Tóthová T, Rosocha L, Sarissky M. Isolation and basic characterization of human term amnion and chorion mesenchymal stromal cells. Cytotherapy. 2011;13:1047-56 pubmed publisher
    ..Amnion and chorion are tissues of early embryologic origin that may entail progenitor potential...
  20. Rus Ciuca D, Soritau O, Susman S, Pop V, Mihu C. Isolation and characterization of chorionic mesenchyal stem cells from the placenta. Rom J Morphol Embryol. 2011;52:803-8 pubmed
    The aim of the study was the isolation and characterization of mesenchymal stem cells from the placental chorion from a genotypical and phenotypical point of view...
  21. Fariha M, Chua K, Tan G, Tan A, Hayati A. Human chorion-derived stem cells: changes in stem cell properties during serial passage. Cytotherapy. 2011;13:582-93 pubmed publisher
    Fetal membrane from human placenta tissue has been described as a potential source of stem cells. Despite abundant literature on amnion stem cells, there are limited studies on the stem cell properties of chorion-derived stem cells.
  22. Inman K, Downs K. The murine allantois: emerging paradigms in development of the mammalian umbilical cord and its relation to the fetus. Genesis. 2007;45:237-58 pubmed
  23. Cavaliere V, Bernardi F, Romani P, Duchi S, Gargiulo G. Building up the Drosophila eggshell: first of all the eggshell genes must be transcribed. Dev Dyn. 2008;237:2061-72 pubmed publisher
    ..This review will summarize our knowledge of eggshell gene expression. We will discuss the amplification of the chorion gene clusters and the data acquired on the expression patterns and the regulatory elements controlling ..
  24. Yuan B, Ohyama K, Takeichi M, Toyoda H. Direct contribution of inducible nitric oxide synthase expression to apoptosis induction in primary smooth chorion trophoblast cells of human fetal membrane tissues. Int J Biochem Cell Biol. 2009;41:1062-9 pubmed publisher
    We have previously demonstrated that apoptosis induction is observed only in smooth chorion laeve trophoblast cells, and not in amnion epithelial cells of human fetal membrane tissues prepared at the term...
  25. Evans R, Fletcher G. Type I antifreeze proteins: possible origins from chorion and keratin genes in Atlantic snailfish. J Mol Evol. 2005;61:417-24 pubmed
    ..Furthermore, it is plausible that one or more of the liver-expressed proteins represent the progenitors of snailfish type I AFPs...
  26. Uchide N, Tadera C, Sarai H, Ohyama K, Bessho T, Toyoda H. Characterization of monocyte differentiation-inducing (MDI) factors derived from human fetal membrane chorion cells undergoing apoptosis after influenza virus infection. Int J Biochem Cell Biol. 2006;38:1926-38 pubmed
    ..We have reported that cultured human fetal membrane chorion cells undergoing apoptosis by influenza virus infection secrete unidentified heat-stable monocyte differentiation-..
  27. Konstandi O, Papassideri I, Stravopodis D, Antonelou M, Kenoutis C, Stefanidou D, et al. The dual role of chorion peroxidase in Bactrocera oleae chorion assembly. Int J Dev Biol. 2006;50:543-52 pubmed
    In the present study, we reveal for the first time that the Bactrocera oleae chorion peroxidase (bPxd) participates essentially in B...
  28. Murtha A, Auten R, Herbert W. Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. Infect Dis Obstet Gynecol. 2002;10:93-6 pubmed
    ..The objective of this investigation was to determine if apoptosis was increased in the chorion laeve of term patients with and without histologic chorioamnionitis.
  29. Johnson R, Mitchell C, Clifton V, Zakar T. Regulation of 15-hydroxyprostaglandin dehydrogenase (PGDH) gene activity, messenger ribonucleic acid processing, and protein abundance in the human chorion in late gestation and labor. J Clin Endocrinol Metab. 2004;89:5639-48 pubmed
    The prostaglandin (PG)-inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH) is highly expressed in the chorion leave...
  30. Kim Y, Romero R, Chaiworapongsa T, Kim G, Kim M, Kuivaniemi H, et al. Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol. 2004;191:1346-55 pubmed
    ..This study examined Toll-like receptor-2 and -4 expression in fetal membranes in response to labor at term and histologic chorioamnionitis...
  31. Mills T, Wareing M, Bugg G, Greenwood S, Baker P. Chorionic plate artery function and Doppler indices in normal pregnancy and intrauterine growth restriction. Eur J Clin Invest. 2005;35:758-64 pubmed
    ..This study aimed to determine whether UA Doppler waveform indices were related to the vasoreactivity of placental chorionic plate small arteries in normal and FGR pregnancies...
  32. Zeigler B, Sugiyama D, Chen M, Guo Y, Downs K, Speck N. The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. Development. 2006;133:4183-92 pubmed
    ..Here, we show that the allantois and chorion, isolated prior to the establishment of circulation, have the potential to give rise to myeloid and definitive ..
  33. Konstandi O, Papassideri I, Stravopodis D, Kenoutis C, Hasan Z, Katsorchis T, et al. The enzymatic component of Drosophila melanogaster chorion is the Pxd peroxidase. Insect Biochem Mol Biol. 2005;35:1043-57 pubmed
    ..demonstrate the isolation and characterization of the Pxd cDNA clone, which codes for the Drosophila melanogaster chorion peroxidase...
  34. Patel F, Challis J. Cortisol/progesterone antagonism in regulation of 15-hydroxysteroid dehydrogenase activity and mRNA levels in human chorion and placental trophoblast cells at term. J Clin Endocrinol Metab. 2002;87:700-8 pubmed
    ..reported previously that cortisol (F) decreases PGDH activity and progesterone (P(4)) maintains PGDH in human chorion and placenta at term...
  35. Goldman S, Weiss A, Almalah I, Shalev E. Progesterone receptor expression in human decidua and fetal membranes before and after contractions: possible mechanism for functional progesterone withdrawal. Mol Hum Reprod. 2005;11:269-77 pubmed
    ..5, respectively (P < 0.05). In immunohistochemical studies, the PR was not identified in the amnion or in the chorion, regardless of the presence or absence of contractions...
  36. Yuan B, Ohyama K, Bessho T, Toyoda H. Contribution of inducible nitric oxide synthase and cyclooxygenase-2 to apoptosis induction in smooth chorion trophoblast cells of human fetal membrane tissues. Biochem Biophys Res Commun. 2006;341:822-7 pubmed
    ..Therefore, we concluded that the induction of apoptosis in the smooth chorion trophoblasts is mediated through oxidative stress induction followed by mitochondria damage, suggesting that iNOS ..
  37. Zhang H, Tower J. Sequence requirements for function of the Drosophila chorion gene locus ACE3 replicator and ori-beta origin elements. Development. 2004;131:2089-99 pubmed
    The developmentally regulated amplification of the Drosophila third chromosome chorion gene locus requires multiple chromosomal elements...
  38. Race J, Townsend G, Hughes T. Chorion type, birthweight discordance and tooth-size variability in Australian monozygotic twins. Twin Res Hum Genet. 2006;9:285-91 pubmed
    b>Chorion type is an important variable that can affect the prenatal environment of monozygotic (MZ) twin pairs, leading to differences in growth and development...
  39. Regier J, Paukstadt U, Paukstadt L, Mitter C, Peigler R. Phylogenetics of eggshell morphogenesis in Antheraea (lepidoptera: saturniidae): unique origin and repeated reduction of the aeropyle crown. Syst Biol. 2005;54:254-67 pubmed
    ..The eggshell (chorion) of Lepidoptera (Insecta) has proven especially tractable experimentally for such analyses because its ..
  40. McKeown K, Challis J. Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. J Clin Endocrinol Metab. 2003;88:1737-41 pubmed
    ..Within the chorion tissue, it is the actions of PGDH that predominate...
  41. Arechavaleta Velasco F, Marciano D, Diaz Cueto L, Parry S. Matrix metalloproteinase-8 is expressed in human chorion during labor. Am J Obstet Gynecol. 2004;190:843-50 pubmed
    ..The purpose of this study was to investigate the expression of matrix metalloproteinase-8 by human fetal membranes during labor...
  42. Zaga V, Estrada Gutierrez G, Beltran Montoya J, Maida Claros R, López Vancell R, Vadillo Ortega F. Secretions of interleukin-1beta and tumor necrosis factor alpha by whole fetal membranes depend on initial interactions of amnion or choriodecidua with lipopolysaccharides or group B streptococci. Biol Reprod. 2004;71:1296-302 pubmed
    ..Thus, cooperative and bidirectional communications occur between amnion and choriodecidua in response to bacterial products, which include intermembranous cytokine traffic and signaling between tissues...
  43. Yonemoto H, Young C, Ross J, Guilbert L, Fairclough R, Olson D. Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor. Placenta. 2006;27:669-77 pubmed
    ..We hypothesized better protein extraction would reveal new MMP patterns. Human amnion and chorion were collected from 25 patients at preterm or term, extracted with 2% SDS (a high concentration), and the MMP ..
  44. Goldberg M, Luknar Gabor N, Keidar R, Katz Y. Synthesis of complement proteins in the human chorion is differentially regulated by cytokines. Mol Immunol. 2007;44:1737-42 pubmed
    The aim of the current paper was to determine the chorion's contribution to complement synthesis in the placenta and its regulation by cytokines...
  45. Johnson R, Mitchell C, Giles W, Bisits A, Zakar T. Mechanisms regulating prostaglandin H2 synthase-2 mRNA level in the amnion and chorion during pregnancy. J Endocrinol. 2006;188:603-10 pubmed
    ..We have determined the activity of the PGHS-2 gene in the amnion and chorion throughout gestation and defined the contribution of transcriptional and post-transcriptional mechanisms to the ..
  46. Uchide N, Suzuki A, Ohyama K, Bessho T, Toyoda H. Secretion of bioactive interleukin-6 and tumor necrosis factor-alpha proteins from primary cultured human fetal membrane chorion cells infected with influenza virus. Placenta. 2006;27:678-90 pubmed
    ..We investigated the secretion of IL-6 and TNF-alpha from primary cultured human fetal membrane chorion and amnion cells infected with influenza virus at protein and bioactivity levels in order to understand the ..
  47. Gow N, Knox Y, Munro C, Thompson W. Infection of chick chorioallantoic membrane (CAM) as a model for invasive hyphal growth and pathogenesis of Candida albicans. Med Mycol. 2003;41:331-8 pubmed
    ..albicans...
  48. Sweeney M, Jones C, Greenwood S, Baker P, Taggart M. Ultrastructural features of smooth muscle and endothelial cells of isolated isobaric human placental and maternal arteries. Placenta. 2006;27:635-47 pubmed
    ..This study highlights ultrastructural differences between placental and maternal arteries that may underlie specialised mechanisms of regulating vascular tone in the placenta...
  49. Uchide N, Ohyama K, Bessho T, Toyoda H. Induction of pro-inflammatory cytokine gene expression and apoptosis in human chorion cells of fetal membranes by influenza virus infection: possible implications for maintenance and interruption of pregnancy during infection. Med Sci Monit. 2005;11:RA7-16 pubmed
    Human fetal membranes are composed of amnion, chorion and decidua tissues, which play a critical role in defense barriers as well as maintenance of pregnancy and parturition...
  50. Zaga Clavellina V, López G, Estrada Gutierrez G, Martínez Flores A, Maida Claros R, Beltran Montoya J, et al. Incubation of human chorioamniotic membranes with Candida albicans induces differential synthesis and secretion of interleukin-1beta, interleukin-6, prostaglandin E, and 92 kDa type IV collagenase. Mycoses. 2006;49:6-13 pubmed
    ..Selective stimulation with C. albicans induced a differential secretion of IL-1beta, PGE(2), and MMP-9, resulting from a cooperative and bidirectional communication between the amnion and the choriodecidua...
  51. Uchide N, Ohyama K, Bessho T, Toyoda H. Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic Acid. Intervirology. 2005;48:336-40 pubmed
    ..We examined effects of an antioxidant, nordihydroguaiaretic acid (NDGA), on apoptosis induction and viral proliferation. Subsequently, the results were compared with those of pyrrolidine dithiocarbamate (PDTC), another antioxidant...
  52. Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim Y, Mazor M, et al. Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature. Am J Obstet Gynecol. 2006;195:394.e1-24 pubmed
    ..The purpose of this study was to identify which biological processes may be involved in normal labor...
  53. Yao R, Li J. Towards global analysis of mosquito chorion proteins through sequential extraction, two-dimensional electrophoresis and mass spectrometry. Proteomics. 2003;3:2036-43 pubmed
    This study describes the separation and identification of chorion proteins through two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) techniques...