eccrine glands

Summary

Summary: Simple sweat glands that secrete sweat directly onto the SKIN.

Top Publications

  1. Hiatt K, Pillow J, Smoller B. Her-2 expression in cutaneous eccrine and apocrine neoplasms. Mod Pathol. 2004;17:28-32 pubmed
    ..Finally, this study suggests that HER-2 protein expression can be a useful tool in differentiating a primary cutaneous appendageal neoplasm from HER-2 expressing metastatic breast carcinoma...
  2. Nakamura M, Tokura Y. The localization of label-retaining cells in eccrine glands. J Invest Dermatol. 2009;129:2077-8 pubmed publisher
  3. Wenzel F, Horn T. Nonneoplastic disorders of the eccrine glands. J Am Acad Dermatol. 1998;38:1-17; quiz 18-20 pubmed
    b>Eccrine glands are uniquely susceptible to a variety of pathologic processes. Alteration in the rate of sweat secretion manifests as hypohidrosis and hyperhidrosis. Obstruction of the eccrine duct leads to miliaria...
  4. Fukui K, Yasui T, Gomi H, Sugiya H, Fujimori O, Meyer W, et al. Histochemical localization of sialic acids and antimicrobial substances in eccrine glands of porcine snout skin. Eur J Histochem. 2012;56:e6 pubmed publisher
    ..of sialic acids and antimicrobial products (lysozyme, IgA, lactoferrin, ?-defensin 2) as well as Rab3D in the eccrine glands of porcine snout skin was studied by sialoglycoconjugate histochemistry and immunohistochemistry...
  5. Swinson B, Ryan F, Barrett A, Jerjes W, Landon G, Calonje E, et al. Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case. Clin Exp Dermatol. 2006;31:786-9 pubmed
    ..However, a metastatic lesion was excluded by clinical and imaging investigations. There has been no recurrence 3 years after primary excision...
  6. Yasui T, Tsukise A, Meyer W. Morphology and glycoconjugate histochemistry of the eccrine glands in the snout skin of the North American raccoon (Procyon lotor). Arch Dermatol Res. 2005;296:482-8 pubmed
    ..This is the first report on the glands in the snout skin of carnivores...
  7. Yasui T, Tsukise A, Meyer W. Histochemical analysis of glycoconjugates in the eccrine glands of the raccoon digital pads. Eur J Histochem. 2004;48:393-402 pubmed
    The distribution and selectivity of complex carbohydrates in the eccrine glands of the digital pads in the North American raccoon (Procyon lotor) were studied using light and electron microscopic histochemical methods, particularly lectin ..
  8. Schröder U, Dries V, Klussmann J, Wittekindt C, Eckel H. Successful adjuvant tamoxifen therapy for estrogen receptor-positive metastasizing sweat gland adenocarcinoma: need for a clinical trial?. Ann Otol Rhinol Laryngol. 2004;113:242-4 pubmed
    ..We suggest examining the hormone receptor expression in these neoplasms regularly. A prospective study should be commenced to assess the benefit of adjuvant antihormonal therapy in eccrine gland adenocarcinomas...
  9. Stumpf P, Künzle H, Welsch U. Cutaneous eccrine glands of the foot pads of the small Madagascan tenrec ( Echinops telfairi, Insectivora, Tenrecidae): skin glands in a primitive mammal. Cell Tissue Res. 2004;315:59-70 pubmed
    ..pattern of cytokeratins of the glandular epithelium was variable and showed similarities to that of the human eccrine glands. Tubulin, vinculin and actin were expressed in the glandular epithelium...

More Information

Publications62

  1. Sato K, Sato F. Effect of VIP on sweat secretion and cAMP accumulation in isolated simian eccrine glands. Am J Physiol. 1987;253:R935-41 pubmed
    ..The functional significance of synergistically accumulated cAMP in physiological eccrine sweating remains to be studied...
  2. Kramer T, Grossniklaus H, McLean I, Orcutt J, Green W, Iliff N, et al. Histiocytoid variant of eccrine sweat gland carcinoma of the eyelid and orbit: report of five cases. Ophthalmology. 2002;109:553-9 pubmed
    ..To study the clinicopathologic features of the histiocytoid variant of adenocarcinoma of the eccrine sweat gland of the eye and orbit...
  3. Stumpf P, Welsch U. Cutaneous eccrine glands of the foot pads of the rock hyrax (Procavia capensis, Hyracoidea, Mammalia). Cells Tissues Organs. 2002;171:215-26 pubmed
    ..The secretory product of the eccrine cutaneous glands seems to improve the traction between the foot pads of these animals and the steep and smooth rock formations among which they live...
  4. Yasui T, Nara T, Habata I, Meyer W, Tsukise A. Functional properties of feline foot pads as studied by lectin histochemical and immunohistochemical methods. Acta Histochem. 2010;112:169-77 pubmed publisher
    ..The lectin binding patterns of the eccrine glands were suggestive of the existence of large concentrations of sialoglycoconjugates that terminated in Siaalpha2-..
  5. Takata M, Hashimoto K, Mehregan P, Lee M, Yamamoto A, Mohri S, et al. Genetic changes in sweat gland carcinomas. J Cutan Pathol. 2000;27:30-5 pubmed
  6. Mahalingam M, Bhawan J, Finn R, Stefanato C. Tumor of the follicular infundibulum with sebaceous differentiation. J Cutan Pathol. 2001;28:314-7 pubmed
  7. Fraedrich J, Ostertag H, Welkoborsky H. [Eccrine porocarcinoma of the cheek skin with parotid gland infiltration]. Laryngorhinootologie. 2008;87:800-4 pubmed publisher
    ..Although the clinical appearance is variable, some tumors present with a diameter of 10 cm or more. In most cases the tumor presents as a slowly growing painless mass...
  8. Misago N, Satoh T, Narisawa Y. Basal cell carcinoma with ductal and glandular differentiation: a clinicopathological and immunohistochemical study of 10 cases. Eur J Dermatol. 2004;14:383-7 pubmed
    ..BCC with tubular structures affected women more than men, and the favored location was the eyelid. The tubular structures in these BCCs differentiated toward either ductal or glandular structures, presumably of apocrine nature...
  9. Chhibber V, Lyle S, Mahalingam M. Ductal eccrine carcinoma with squamous differentiation: apropos a case. J Cutan Pathol. 2007;34:503-7 pubmed
    ..As the distinction between these two neoplasms is crucial to patient management, we highlight the histologic features of this uncommon entity to highlight the potential diagnostic pitfalls...
  10. Saga K, Jimbow K. Immunohistochemical localization of activated EGF receptor in human eccrine and apocrine sweat glands. J Histochem Cytochem. 2001;49:597-602 pubmed
    ..Because ductal cells do not express EGF, EGF in the sweat secreted from the secretory cells should activate EGFR in the ductal cells in a paracrine manner. (J Histochem Cytochem 49:597-601, 2001)..
  11. Ibrahim S, Pryor J, Merritt R, Scott G, Beck L. Cutaneous myiasis arising in an eccrine adnexal neoplasm. Dermatol Online J. 2008;14:6 pubmed
    ..We report here a case of cutaneous myiasis observed in the setting of an eccrine adnexal neoplasm in an otherwise healthy host. Entomological analysis of the isolated organisms revealed additional information of interest...
  12. Sommer B, Hagedorn M, Wood F, Heenan P. Eccrine squamous syringometaplasia in the skin of children after burns. J Cutan Pathol. 1998;25:56-8 pubmed
    ..These cases appear to be the first reported instances of ESS as an early consequence of severe burns...
  13. Kazakov D, Spagnolo D, Kacerovska D, Kempf W, Michal M. Cutaneous adenolipoma: extending the spectrum of changes in the lipomatous and epithelial components. Am J Dermatopathol. 2011;33:56-9 pubmed publisher
  14. Jain V, Singh U, Gupta S. Multiple eccrine spiradenomas in zosteriform distribution in a child. Pediatr Dermatol. 2000;17:384-6 pubmed
    ..A literature search produced reports of 10 cases of linear/zosteriform spiradenoma. Of these, five were in children or adolescents. We report this patient because of the rare occurrence of this presentation...
  15. Stefanato C, Simkin D, Bhawan J. An unusual melanocytic lesion associated with eccrine duct fibroadenomatosis and syringoid features. Am J Dermatopathol. 2001;23:139-42 pubmed
    ..The location of the lesion on the heel in our case suggests the possibility that the pathologic changes observed could result from repetitive trauma...
  16. Baysse L, Boralevi F, Lepreux S, Boyer A, Morel C, Leaute Labreze C, et al. [Eccrine squamous syringometaplasia and cytomegalovirus infection]. Rev Med Interne. 2003;24:394-8 pubmed
    ..We report a case of eccrine squamous syringometaplasia associated with a severe cytomegalovirus infection in an immunocompromised patient, and we discuss about potential viral or drug triggering factors...
  17. Gordon S, Styron B, Haggstrom A. Pediatric segmental eccrine spiradenomas: a case report and review of the literature. Pediatr Dermatol. 2013;30:e285-6 pubmed publisher
    ..Segmental eccrine spiradenomas have rarely been reported with onset occurring in childhood or adolescence. We describe a case of segmental eccrine spiradenomas occurring on the neck and mandible of a child. ..
  18. Goddard A, Hillman A, Bond J. High resolution imaging of latent fingerprints by localized corrosion on brass surfaces. J Forensic Sci. 2010;55:58-65 pubmed publisher
    ..AFM examination of surface regions between ridges revealed small deposits (probably microscopic "spatter" of sweat components or transferred particulates) that may ultimately limit the level of ridge detail analysis...
  19. Mitsui H, Watanabe T, Jinnin M, Kadono T, Idezuki T, Tamaki K. Mucinous carcinoma of the skin could have either an eccrine or an apocrine origin. Br J Dermatol. 2004;151:1285-6 pubmed
  20. Aydin E, Akdogan V, Akkuzu G, Ilgici D. Malignant eccrine poroma invading the parotid gland. Acta Otolaryngol. 2006;126:435-7 pubmed
    ..The lesion was treated using a superficial parotidectomy approach including the overlying skin. Simultaneous neck dissection was performed. The diagnosis was malignant eccrine poroma invading the parotid gland...
  21. Lawrence C, Lonsdale Eccles A. Selective sweat gland removal with minimal skin excision in the treatment of axillary hyperhidrosis: a retrospective clinical and histological review of 15 patients. Br J Dermatol. 2006;155:115-8 pubmed
    ..Limited axillary skin excision and selective sweat gland removal from adjacent skin (Shelley's procedure) is currently rarely used for hyperhidrosis...
  22. Lei X, Wu J, Lu Y, Zhu T, Yang Y. [Effect of hepatocyte growth factor on proliferation of cultured human eccrine sweat gland epithelial cells]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008;22:614-8 pubmed
    ..To investigate the effect of hepatocyte growth factor (HGF) on proliferation of cultured human eccrine sweat gland epithelial cells (hESGc) and the involvement of phosphorylation of ERK1/2...
  23. Bovell D, Clunes M, Elder H, Milsom J, Jenkinson D. Ultrastructure of the hyperhidrotic eccrine sweat gland. Br J Dermatol. 2001;145:298-301 pubmed
    Hyperhidrosis is the secretion of inappropriately large amounts of sweat by eccrine glands; it can be very debilitating. Little is known of the causes of primary hyperhidrosis.
  24. Lu C, Jung S, Lin Y. Sclerosing syringoid carcinoma of the finger. Chang Gung Med J. 2011;34:115-21 pubmed
    ..The disease presentation and the difficulties encountered during establishment of the diagnosis and planning of the treatment are discussed...
  25. Sedrak M, Marek M, Matherene R, Kelly B. Syringitis: a clue to herpes infection. Dermatol Online J. 2012;18:6 pubmed
    ..may occasionally involve the hair follicles or sebaceous glands, it is very rare to find HSV involving the eccrine glands. We present a case of a 13-month-old child with a large body burn diagnosed with HSV (in the absence of the ..
  26. Lencastre A, Lobo M, João A. Argyria -- case report. An Bras Dermatol. 2013;88:413-6 pubmed publisher
  27. Tian J, Huang Y, Deng Y, Chen J, Ma L, Chen X, et al. Effects of topiramate on mouse eccrine sweat gland responsiveness to heat exposure. Basic Clin Pharmacol Toxicol. 2007;100:377-82 pubmed
  28. Betlloch I, Vergara G, Albares M, Pascual J, Silvestre J, Botella R. Aquagenic keratoderma. J Eur Acad Dermatol Venereol. 2003;17:306-7 pubmed
  29. Neri I, Bianchi F, Patrizi A. Transient aquagenic palmar hyperwrinkling: the first instance reported in a young boy. Pediatr Dermatol. 2006;23:39-42 pubmed
    ..Until now, a total of 12 patients have been reported in the literature, all female, with an age of onset from 9 to 33 years. We present the first reported instance of this condition in a young boy...
  30. Murphy L, DJ D. Case 2. Porokeratotic eccrine and ostial dermal duct naevus. Clin Exp Dermatol. 2004;29:333-4 pubmed
  31. Sakai H, Satoh K, Manabe A, Nakane H, Ishida Yamamoto A, Iizuka H. Eccrine squamous syringometaplasia and syringomatous hyperplasia in association with linear scleroderma. Dermatology. 2002;204:136-8 pubmed
    ..To the best of our knowledge, the association of syringomatous hyperplasia with eccrine squamous syringometaplasia and linear scleroderma has not been described previously...
  32. Heckmann M, Teichmann B, Pause B, Plewig G. Amelioration of body odor after intracutaneous axillary injection of botulinum toxin A. Arch Dermatol. 2003;139:57-9 pubmed
    ..It is commonly attributed to sweating and noted explicitly in the axillary area. Botulinum toxin A has recently been shown to be effective for axillary hyperhidrosis. Its effect on axillary odor, however, is unknown...
  33. Kim J, Kim Y, Lee E. Solitary eccrine syringofibroadenoma with prominent plasma cell infiltration. J Dermatol. 2007;34:138-41 pubmed
    ..Clinicopathological features of both cases suggest that acrosyringeal nevus and ESFA may be of the same disease entity. Prominent plasma cell infiltration may be just one of the common histological features of ESFA...
  34. Battistella M, Fraitag S, Cribier B. A unique presentation of eccrine hamartoma: eccrine nevus with abnormal eccrine structures and angiomyxoid stroma. Am J Dermatopathol. 2009;31:682-4 pubmed publisher
    ..These lesions are all characterized by an increase in number and/or size of normal eccrine glands. We report the case of a hamartomatous lesion composed of eccrine structures and prominent angiomyxoid stroma, ..
  35. Buono M, Claros R, Deboer T, Wong J. Na+ secretion rate increases proportionally more than the Na+ reabsorption rate with increases in sweat rate. J Appl Physiol (1985). 2008;105:1044-8 pubmed publisher
  36. Garcia Navarro X, Puig L, Fernández Figueras M, Alomar A. Eccrine squamous syringometaplasia secondary to pegylated liposomal doxorubicin. Arch Dermatol. 2008;144:1402-3 pubmed publisher
  37. Tsuboi H, Yonemoto K, Katsuoka K. A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature. J Dermatol. 2005;32:921-5 pubmed
    ..It is thought that the accumulation of chemotherapeutic drugs in eccrine glands may cause eccrine squamous syringometaplasia (ESS), which is characterized by metaplasia and focal necrosis of ..
  38. Starkenmann C, Mayenzet F, Brauchli R, Troccaz M. 5?-Androst-16-en-3?-ol ?-D-glucuronide, precursor of 5?-androst-16-en-3?-ol in human sweat. Chem Biodivers. 2013;10:2197-208 pubmed publisher
  39. Iannicelli E, Galluzzo A, Salvi P, Ziparo V, David V. A large porocarcinoma of perineal region: MR findings and review of the literature. Abdom Imaging. 2008;33:744-7 pubmed publisher
    ..We present the case of a 54-year-old woman affected by a large perineal region eccrine porocarcinoma, with a wide local invasion. We discuss the clinical presentation and the imaging findings and review the literature...
  40. Bechara F, Sand M, Hoffmann K, Boorboor P, Altmeyer P, Stuecker M. Histological and clinical findings in different surgical strategies for focal axillary hyperhidrosis. Dermatol Surg. 2008;34:1001-9; discussion 1009 pubmed publisher
    ..Although a variety of different surgical strategies for focal axillary hyperhidrosis (FAH) have proven effective, little is known of intraoperative and postoperative histologies of different surgical methods...
  41. Ohmori R, Kikuchi K, Yamasaki K, Aiba S. A new type of annular erythema with perieccrine inflammation: erythema papulatum centrifugum. Dermatology. 2013;226:298-301 pubmed publisher
    ..We discuss EPC as compared with other cutaneous disorders showing annular erythema or similar histopathology and suggest that EPC is a distinct clinical entity...
  42. Chen C, Tsai T, Chen Y, Hung C. Congenital mucinous eccrine nevus in a 5-month-old girl with frequent intertriginous dermatitis. Pediatr Dermatol. 2008;25:573-4 pubmed publisher
    ..Localized hyperhidrosis was also noted. Histopathologic examination of the lesion showed typical findings of mucinous eccrine nevus. Our report may serve to alert dermatologists to consider this entity in congenital lesions...
  43. Iwasaki J, Yoshida Y, Yamamoto O, Tajima S. Poroma with sebaceous differentiation of the eyelid: a rare site of occurrence. Acta Derm Venereol. 2008;88:166-7 pubmed publisher
  44. Kanda A, Nakao S, Tsuyama S, Murata F, Kanzaki T. Fabry disease: ultrastructural lectin histochemical analyses of lysosomal deposits. Virchows Arch. 2000;436:36-42 pubmed
    ..The experimental procedures used in this study have considerable potential for use in investigations of glycolipid and glycoprotein storage diseases without the need for complex methodology and expensive materials...
  45. Yu H, Ko J, Kwon H, Kim J. Linear psoriasis with porokeratotic eccrine ostial and dermal duct nevus. J Am Acad Dermatol. 2004;50:S81-3 pubmed
    ..A 7-year-old boy had a 4-month history of multiple psoriasiform plaques, arranged in linear distribution, and had congenital linear hyperkeratotic papules and pits on the right side of his trunk and right arm...
  46. Fukui K, Yasui T, Gomi H, Sugiya H, Fujimori O, Meyer W, et al. Histochemical distribution of sialic acids and antimicrobial substances in porcine carpal glands. Arch Dermatol Res. 2012;304:599-607 pubmed publisher
    ..These secretory products may create a defensive barrier against microbial invasion and play an essential role in the preservation of skin integrity...
  47. Wollina U, Lange D, ten Dijke P, Heldin C, Funa K. Eccrine sweat glands: expression of transforming growth factor-beta and bone morphogenetic protein type I receptors and their intracellular signalling Smad proteins. Acta Derm Venereol. 1999;79:183-6 pubmed
    ..Myoepithelial cells and duct cells have been identified as major targets of the transforming growth factor-beta pathway. Possible functions are growth inhibition and control of myoepithelial differentiation...
  48. Rutten A. [Eccrine sweat gland carcinoma of the skin]. Pathologe. 2002;23:79-88 pubmed
  49. Chen S, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, et al. Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma. J Dermatol Sci. 2008;49:170-3 pubmed
  50. Cui C, Sima J, Yin M, Michel M, Kunisada M, Schlessinger D. Identification of potassium and chloride channels in eccrine sweat glands. J Dermatol Sci. 2016;81:129-31 pubmed publisher
  51. Arda O, Goksugur N, Tuzun Y. Basic histological structure and functions of facial skin. Clin Dermatol. 2014;32:3-13 pubmed publisher
    ..The dermis underlies the epidermis. The hypodermis is a looser connective tissue that is located beneath the dermis. It blends to the dermis with an unclear boundary. ..
  52. Gerber P, Schulte K, Ruzicka T, Bruch Gerharz D. Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology. 2008;216:229-33 pubmed publisher
    ..Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein...
  53. Toll A, Gallardo F, Jucgla A, Pujol R. Multifocal segmental hyperthermic and hyperhidrotic naevus flammeus: a peculiar variant of eccrine angiomatous hamartoma?. Clin Exp Dermatol. 2007;32:696-8 pubmed
    ..Histopathologically, EAH is manifested by lobules of mature eccrine glands and ducts closely associated with well-differentiated, thin-walled blood vessels...