sublingual gland

Summary

Summary: A salivary gland on each side of the mouth below the TONGUE.

Top Publications

  1. Noble R. Salivary alpha-amylase and lysozyme levels: a non-invasive technique for measuring parotid vs submandibular/sublingual gland activity. J Oral Sci. 2000;42:83-6 pubmed
    ..This methodology obviates the need for invasive cannulation techniques. The findings also show that strong taste stimuli, such as salt, activate the submandibular/sublingual glands more as compared to the parotid gland...
  2. McGurk M, Eyeson J, Thomas B, Harrison J. Conservative treatment of oral ranula by excision with minimal excision of the sublingual gland: histological support for a traumatic etiology. J Oral Maxillofac Surg. 2008;66:2050-7 pubmed publisher
    ..new conservative technique for the treatment of oral ranula based on the premise that a discrete unit of the sublingual gland feeds the ranula, which can therefore be treated by local removal with the attached part of the sublingual ..
  3. Yamashina S, Tamaki H, Katsumata O. The serous demilune of rat sublingual gland is an artificial structure produced by conventional fixation. Arch Histol Cytol. 1999;62:347-54 pubmed
    The ultrastructure of the secretory end-piece of the rat sublingual gland was examined in samples prepared by rapid freezing and freeze-substitution method, and results were analyzed in combination with 3-D images reconstructed by ..
  4. Denny P, Hagen F, Hardt M, Liao L, Yan W, Arellanno M, et al. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008;7:1994-2006 pubmed publisher
  5. Takahashi S, Shinzato K, Nakamura S, Domon T, Yamamoto T, Wakita M. The roles of apoptosis and mitosis in atrophy of the rat sublingual gland. Tissue Cell. 2002;34:297-304 pubmed
    The roles of apoptosis and mitosis of acinar and duct cells in the atrophy of the sublingual gland of rat induced by double duct ligation was investigated using immunohistochemistry for proliferating cell nuclear antigen (PCNA), terminal ..
  6. Sakulsak N, Wakayama T, Hipkaeo W, Yamamoto M, Iseki S. Cloning and characterization of a novel animal lectin expressed in the rat sublingual gland. J Histochem Cytochem. 2005;53:1335-43 pubmed
    We cloned a rat gene that is expressed primarily in the sublingual gland and named the predicted 503 amino-acid protein SLAMP (sublingual acinar membrane protein)...
  7. Crean S, Adams R, Bennett J. Sublingual gland involvement in systemic Wegener's granulomatosis: a case report. Int J Oral Maxillofac Surg. 2002;31:104-6 pubmed
    ..A case report is presented of sublingual gland presentation, confirmed on biopsy, which proceeded to systemic involvement...
  8. Azevedo L, Damante J, Lara V, Lauris J. Age-related changes in human sublingual glands: a post mortem study. Arch Oral Biol. 2005;50:565-74 pubmed
    ..To analyse age- and gender-related microscopic changes in sublingual glands obtained from human cadavers...
  9. Moreira C, Azevedo L, Lauris J, Taga R, Damante J. Quantitative age-related differences in human sublingual gland. Arch Oral Biol. 2006;51:960-6 pubmed
    ..To quantify morphological age- and gender-related differences in human sublingual glands (SLG)...

More Information

Publications62

  1. Choi J, Kim I, Oh N. Multiple sialoliths in sublingual gland: report of a case. Int J Oral Maxillofac Surg. 2002;31:562-3 pubmed
    We describe a 28-year-old woman with multiple sialoliths in the left sublingual gland. The sialoliths were removed by transoral sublingual sialadenectomy. A total of 22 calculi were found.
  2. Kurihara K, Nakanishi N, Amano O, Tonosaki K. Expression of Na(+)/K(+)-ATPase alpha subunit isoforms in rat salivary glands: occurrence of sense and antisense RNAs of the alpha3 isoform in the sublingual gland. Arch Oral Biol. 2008;53:593-604 pubmed publisher
    ..The alpha2 isoform was expressed in both submandibular gland (SMG) and sublingual gland (SLG) but faintly in the parotid gland (PG)...
  3. Troxler R, Iontcheva I, Oppenheim F, Nunes D, Offner G. Molecular characterization of a major high molecular weight mucin from human sublingual gland. Glycobiology. 1997;7:965-73 pubmed
    Human submandibular/sublingual gland secretions contain a multimeric high molecular weight mucin (MG1) and a monomeric low molecular weight mucin (MG2). MG2 is the product of the MUC7 gene, whereas the gene for MG1 has not been identified...
  4. Tagawa S, Inui M, Mori A, Seki Y, Murata T, Tagawa T. Adenomatoid serous hyperplasia of sublingual gland: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:437-40 pubmed
    We present an example of adenomatoid serous lobular hyperplasia of the sublingual gland. Pathologic examination revealed the lesion was composed of multiple aggregates of normal-appearing serous and mucous acini that varied in size...
  5. Zhao Y, Jia Y, Chen X, Zhang W. Clinical review of 580 ranulas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:281-7 pubmed
    ..The purpose of this paper was to compare clinical features among 3 patterns of ranula and the recurrence rates of each when treated by different surgical methods...
  6. Morita Y, Sato K, Kawana M, Takahasi S, Ikarashi F. Treatment of ranula--excision of the sublingual gland versus marsupialization. Auris Nasus Larynx. 2003;30:311-4 pubmed
    ..In five cases including recurrence cases, the sublingual gland was excised...
  7. Chanthaphavong R, Murphy S, Anderson C. The effect of the transplanted pineal gland on the sympathetic innervation of the rat sublingual gland. Cell Tissue Res. 2004;317:165-72 pubmed
    We investigated the effect of the pineal on sympathetic neurons that normally innervate the sublingual gland of the rat...
  8. Nery L, Moreira C, Cestari T, Taga R, Damante J. Postmortem acinar autolysis in rat sublingual gland: a morphometric study. J Appl Oral Sci. 2010;18:509-14 pubmed
    ..The morphometric analysis of the volume density (Vv) and total volume (Vt) of intact (ia) and autolyzed (aa) acini was performed under light microscopy using a Zeiss II integration grid with 100 symmetrically distributed points...
  9. Zhao Y, Jia J, Jia Y. Complications associated with surgical management of ranulas. J Oral Maxillofac Surg. 2005;63:51-4 pubmed
    ..We present the intraoperative and postoperative complications associated with 606 procedures for ranulas in a series of 571 patients...
  10. Hayashi Y, Kojima A, Hata M, Hirokawa K. A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation. Am J Pathol. 1988;132:187-91 pubmed
    ..The genetic analysis showed that a single autosomal recessive gene determined the observed abnormality. This is the first salivary gland mutation and will provide a critical model for the study of salivary mucous cell differentiation...
  11. Cankaya H, Unal O, Ugras S, Yuca K, Kiris M. Hemangioma with phleboliths in the sublingual gland: as a cause of submental opacity. Tohoku J Exp Med. 2003;199:187-91 pubmed
    ..We present the first case of a hemangioma with multiple phleboliths in the subligual gland as a cause of submental opacity, and discussed the diagnosis of radiopaque masses in the sublingual and submental regions...
  12. Hong K, Yang Y. Sialolithiasis in the sublingual gland. J Laryngol Otol. 2003;117:905-7 pubmed
    ..The submandibular gland is the most common site followed by the parotid gland. The sublingual gland and minor glands are very rare sites for stone formation...
  13. Pijpe J, Kalk W, Bootsma H, Spijkervet F, Kallenberg C, Vissink A. Progression of salivary gland dysfunction in patients with Sjogren's syndrome. Ann Rheum Dis. 2007;66:107-12 pubmed
    ..Salivary gland dysfunction is one of the key manifestations of Sjögren's syndrome...
  14. Sumi M, Izumi M, Yonetsu K, Nakamura T. Sublingual gland: MR features of normal and diseased states. AJR Am J Roentgenol. 1999;172:717-22 pubmed
    We describe the MR features of the sublingual gland in normal and diseased states.
  15. Bhatt V, Evans M, Malins T. Squamous cell carcinoma arising in the lining of an epidermoid cyst within the sublingual gland--a case report. Br J Oral Maxillofac Surg. 2008;46:683-5 pubmed publisher
    ..the case of squamous cell carcinoma that arose in the lining of an epidermoid cyst that developed within the sublingual gland in a 64-year-old woman...
  16. Das B, Cash M, Hand A, Shivazad A, Culp D. Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells. J Histochem Cytochem. 2009;57:383-96 pubmed publisher
    ..These changes in Muc19/Smgc gene expression delineate multiple stages of salivary mucous cell cytodifferentiation and subsequent maturation during embryonic gland development through the first 4 weeks of postnatal life...
  17. de Albuquerque S, Lopes R, Sala M, Abrahão A, Rosa D. [Histometry of the sublingual gland in male and female mice (Mus musculus) infected with the RAL strain of the Chagas parasite, Trypanosoma cruzi]. Rev Biol Trop. 2008;56:459-71 pubmed
    The aim of this work was to analyze histologically and histometrically the sublingual gland of mice infected with the RAL strain of T. cruzi, according to the sex...
  18. Patel M, Deal A, Shockley W. Oral and plunging ranulas: What is the most effective treatment?. Laryngoscope. 2009;119:1501-9 pubmed publisher
    ..Preferred treatment of oral/plunging ranulas remains controversial. We present our experience with ranulas at the University of North Carolina (UNC) and review the literature...
  19. Kawabata A, Morimoto N, Nishikawa H, Kuroda R, Oda Y, Kakehi K. Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland. Biochem Biophys Res Commun. 2000;270:298-302 pubmed
    ..In the isolated sublingual gland that exhibited the strongest signal for PAR-2, Ser-Leu-Ile-Gly-Arg-Leu-NH(2), a PAR-2-activating peptide, and ..
  20. Yoshida K, Aiyama S, Uchida M, Kurabuchi S. Role of thyroid hormone in the initiation of EGF (epidermal growth factor) expression in the sublingual gland of the postnatal mouse. Anat Rec A Discov Mol Cell Evol Biol. 2005;284:585-93 pubmed
  21. Rosivack R. Comparison of submandibular/sublingual salivary flow rates in children and adolescents. J Dent Child (Chic). 2004;71:38-40 pubmed
    ..This study compared age related changes in submandibular/sublingual salivary flow rates in children and adolescents...
  22. Friedman E, Saindane A. Pitfalls in the staging of cancer of the major salivary gland neoplasms. Neuroimaging Clin N Am. 2013;23:107-22 pubmed publisher
    ..This article reviews the various histologies, imaging features, and staging of major salivary gland neoplasms...
  23. Niemelä R, Takalo R, Paakko E, Suramo I, Paivansalo M, Salo T, et al. Ultrasonography of salivary glands in primary Sjogren's syndrome. A comparison with magnetic resonance imaging and magnetic resonance sialography of parotid glands. Rheumatology (Oxford). 2004;43:875-9 pubmed
    ..To evaluate ultrasonography (US) of salivary glands in primary Sjögren's syndrome (SS) and to compare US with parotid magnetic resonance (MR) imaging and MR sialography...
  24. Slomiany B, Slomiany A. Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase. J Physiol Pharmacol. 2002;53:325-36 pubmed
    ..Nitric oxide (NO), a pluripotent molecule, is an important biological messenger that plays a role in the regulation of tissue homeostasis and pathophysiological processes...
  25. Bolscher J, Nazmi K, Ran L, van Engelenburg F, Schuitemaker H, Veerman E, et al. Inhibition of HIV-1 IIIB and clinical isolates by human parotid, submandibular, sublingual and palatine saliva. Eur J Oral Sci. 2002;110:149-56 pubmed
    ..In conclusion, saliva inhibits HIV-1-infection by the action of high molecular weight components in combination with low molecular weight components from serous as well as mucous saliva, affecting different stages of the infection cycle...
  26. Haberal I, Gocmen H, Samim E. Surgical management of pediatric ranula. Int J Pediatr Otorhinolaryngol. 2004;68:161-3 pubmed
    ..Few studies have compared the results of the most popular techniques such as excision and marsupialization in pediatric population...
  27. Beltzer E, Fortunato C, Guaderrama M, Peckins M, Garramone B, Granger D. Salivary flow and alpha-amylase: collection technique, duration, and oral fluid type. Physiol Behav. 2010;101:289-96 pubmed publisher
    ..Management of these potential sources of measurement error will be essential to ensuring the success of future research on the correlates and concomitants of sAA activity, stress-related reactivity and recovery, and diurnal variation...
  28. León J, Mauad T, Saldiva P, Almeida O, Vargas P. Submandibular and sublingual glands involvement in advanced acquired immunodeficiency syndrome (AIDS): an autopsy-based study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:216-26 pubmed publisher
    ..To assess the histopathological, immunohistochemical (IHC), and in situ hybridization (ISH) features found in the submandibular (SM) and sublingual (SL) glands of 105 acquired immunodeficiency syndrome (AIDS) patients at autopsy...
  29. Laursen J, Larsen H, Mikkelsen T, Hjorth J. Allele-specific expression of the PSP gene in the mouse sublingual glands. Genet Res. 1998;71:187-91 pubmed
    ..This indicates that only Pspb is expressed in this tissue. Furthermore, it maps the allele-specific sublingual gland determinant within 3.4 cM of Psp. Previous analysis of Pspb identified an enhancer-like region in position -4...
  30. Zhi K, Wen Y, Zhou H. Management of the pediatric plunging ranula: results of 15 years' clinical experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:499-502 pubmed publisher
    ..This study was designed to evaluate the diagnosis and surgical treatment of the plunging ranula in children...
  31. Barrett A. Wegener's granulomatosis of the major salivary glands. J Oral Pathol Med. 2012;41:721-7 pubmed publisher
    ..A detailed medical history, and persistently inconclusive laboratory tests, could provide the clues that enable prompt diagnosis...
  32. Walvekar R, Peters G, Hardy E, Alsfeld L, Stromeyer F, Anderson D, et al. Robotic-assisted transoral removal of a bilateral floor of mouth ranulas. World J Surg Oncol. 2011;9:78 pubmed publisher
    ..To describe the management of bilateral oral ranulas with the use of the da Vinci Si Surgical System and discuss advantages and disadvantages over traditional transoral resection...
  33. Bobek L, Tsai H, Biesbrock A, Levine M. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J Biol Chem. 1993;268:20563-9 pubmed
    ..MG2 mRNA is about 2.5 kilobases long, and its expression appears to be species-, tissue-, and cell-specific. We propose to name this gene MUC7 in accordance with the mucin genes cloned to date named MUC1-MUC6...
  34. Denny P, Liu P, Denny P. Evidence of a phenotypically determined ductal cell lineage in mouse salivary glands. Anat Rec. 1999;256:84-90 pubmed
    ..Throughout development of the sublingual gland, preproNGF-A was detectable in the striated ducts or in their predecessors, suggesting that they may also ..
  35. Omidfar H, Guven Y, Oz H. The effect of heat-stable extract from bovine sublingual salivary gland on serum cholesterol and triglyceride levels in normal and hypercholesterolemic rabbits. Horm Metab Res. 1989;21:646-8 pubmed
    ..0% and triglyceride levels 46.5% in hypercholesterolemic rabbits, while in similar rabbits injected with a control muscle tissue extract, the rate of decrease in serum cholesterol levels was 33.3% and triglyceride levels 26.7%...
  36. Yao J, Chen G, Lin F, Lin C, Tao T. [Studies on the saliva adsorption and the salivary film property on the hydroxyapatite surface]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2012;47:439-43 pubmed publisher
    To evaluate the thickness and viscoelasticity of whole saliva (WS), parotid saliva (PS) and submandibular/sublingual gland saliva (SMSLS) film adsorption on the hydroxyapatite (HA) surface.
  37. Ching K, Burbelo P, Gonzalez Begne M, Roberts M, Coca A, Sanz I, et al. Salivary anti-Ro60 and anti-Ro52 antibody profiles to diagnose Sjogren's Syndrome. J Dent Res. 2011;90:445-9 pubmed publisher
    ..These results suggest that LIPS salivary-based testing for SjS autoantibodies is a practical alternative to serum and compatible with point-of-care testing...
  38. Shahan K, Denaro M, Gilmartin M, Shi Y, Derman E. Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver. Mol Cell Biol. 1987;7:1947-54 pubmed
    ..When a particular MUP gene is expressed in several tissues, transcripts of this gene initiate at the same site and are spliced and polyadenylated in the same manner...
  39. Troxler R, Offner G, Zhang F, Iontcheva I, Oppenheim F. Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem Biophys Res Commun. 1995;217:1112-9 pubmed
    A human sublingual gland cDNA library was screened with a polyclonal antiserum against deglycosylated MG1 and a positive clone, pSM2-1, was isolated which codes for 196 amino acids in the carboxyl-terminal region of this mucin...
  40. Rautiainen J, Rytkönen M, Syrjanen K, Pentikäinen J, Zeiler T, Virtanen T, et al. Tissue localization of bovine dander allergen Bos d 2. J Allergy Clin Immunol. 1998;101:349-53 pubmed
    ..Domestic mammals are important sources of indoor allergens. However, the origin at the tissue level and the biologic function of mammalian allergens are largely unknown...
  41. Jászai J, Janich P, Farkas L, Fargeas C, Huttner W, Corbeil D. Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice. Histochem Cell Biol. 2007;128:409-19 pubmed
    ..Finally, we report that Prominin-2, like Prominin-1, is released into the human saliva associated with small membrane particles holding the potential for future diagnostic applications...
  42. Shaw P, Zhang X, Russo A, Amendt B, Henderson S, Williams V. Homeobox protein, Hmx3, in postnatally developing rat submandibular glands. J Histochem Cytochem. 2003;51:385-96 pubmed
    ..The duct cells show increasing concentrations of Hmx3 protein with progressive development of the submandibular gland. In contrast, the acinar cells of the three salivary glands do not exhibit detectable levels of Hmx3 protein...
  43. Nguyen H, Stuart Tilley A, Alper S, Melvin J. Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004;286:G312-20 pubmed
    ..Moreover, muscarinic receptor stimulation enhanced AE activity through a Ca(2+)-dependent mechanism. Such forms of regulation may play important roles in modulating fluid and electrolyte secretion by salivary gland acinar cells...
  44. Veerman E, van den Keybus P, Vissink A, Nieuw Amerongen A. Human glandular salivas: their separate collection and analysis. Eur J Oral Sci. 1996;104:346-52 pubmed
    ..Submandibular salivas contain highest concentration of salivary cystatin S. Palatine secretions contain high molecular weight mucins and a relatively high amylase concentration...
  45. Izumi M, Watanabe M, Sawaki K, Yamaguchi H, Kawaguchi M. Expression of BMP7 is associated with resistance to diabetic stress: comparison among mouse salivary glands. Eur J Pharmacol. 2008;596:1-5 pubmed publisher
    ..These results suggest that BMP7 acts to prevent diabetic damage in salivary gland, and that its cytoprotective effect is closely correlated with mRNA levels in tissue...
  46. Ahmed M, Strauss M, Kassaie A, Shotelersuk V, Deguzman R. Bilateral submandibular gland aplasia with clinico-radiological mass due to prolapsing sublingual salivary tissue through mylohyoid boutonniere: a case report and review. Dentomaxillofac Radiol. 2009;38:121-4 pubmed publisher
    ..Multiplanar evaluation is emphasised by utilizing multidetector CT...
  47. Johnson D, Yeh C, Dodds M. Effect of donor age on the concentrations of histatins in human parotid and submandibular/sublingual saliva. Arch Oral Biol. 2000;45:731-40 pubmed
    ..These results suggest that the salivary histatin component of the oral host defence system is compromised with increasing age...
  48. Vreugdenhil A, Nieuw Amerongen A, de Lange G, Roukema P. Localization of amylase and mucins in the major salivary glands of the mouse. Histochem J. 1982;14:767-80 pubmed
    ..Amylase was localized in the acinar cells of the parotid gland with both localization techniques. In the sublingual gland, amylase was found predominantly in the stroma around the acini, and there was some evidence that amylase was ..
  49. Iida S, Kogo M, Tominaga G, Matsuya T. Plunging ranula as a complication of intraoral removal of a submandibular sialolith. Br J Oral Maxillofac Surg. 2001;39:214-6 pubmed
    ..Mucous cysts in the submandibular region--so-called 'plunging' ranula--are relatively uncommon. We report a case of a plunging ranula that complicated excision of an intraductal sialolith of the submandibular gland...
  50. de Courten A, Küffer R, Samson J, Lombardi T. Anterior lingual mandibular salivary gland defect (Stafne defect) presenting as a residual cyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:460-4 pubmed
    ..Histopathologic examination of the "cyst" content revealed the absence of a cyst lining and the presence of normal sublingual gland tissue.
  51. Fallon M, Latchney L, Hand A, Johar A, Denny P, Georgel P, et al. The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression. Physiol Genomics. 2003;14:95-106 pubmed
    NFS/N-sld mice harbor a spontaneous autosomal recessive mutation, sld (sublingual gland differentiation arrest) and histologically display attenuated mucous cell expression in sublingual glands (Hayashi et al...
  52. Ghezzi E, Ship J. Aging and secretory reserve capacity of major salivary glands. J Dent Res. 2003;82:844-8 pubmed
    ..These findings suggest that salivary gland output is more adversely affected by an anti-sialogogue in healthy older vs. younger adults, supporting the secretory reserve hypothesis of salivary function...
  53. Kikuchi K, Aiyama S, Ikeda R, Matsuoka T, Takada K. Granule types and their morphological changes in terminal cluster and acinar cells in the late pre- and early postnatal rat sublingual gland. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:209-15 pubmed
    The developmental characteristics of serous cells appearing in the rat sublingual gland from the late prenatal to the early postnatal period were investigated in this study...