minor salivary glands

Summary

Summary: Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.

Top Publications

  1. Steinfeld S, Appelboom T, Delporte C. Treatment with infliximab restores normal aquaporin 5 distribution in minor salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 2002;46:2249-51 pubmed
  2. Noonan V, Kalmar J, Allen C, Gallagher G, Kabani S. Sclerosing polycystic adenosis of minor salivary glands: report of three cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:516-20 pubmed
    ..We report 3 cases of SPCA involving minor salivary glands and discuss the characteristic histopathologic features of SPCA , which include a combination of fibrosis, ..
  3. Epivatianos A, Iordanides S, Zaraboukas T, Antoniades D. Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of minor salivary glands: a comparative immunohistochemical study using the epithelial membrane and carcinoembryonic antibodies. Oral Dis. 2005;11:175-80 pubmed
  4. Bianchi B, Copelli C, Cocchi R, Ferrari S, Pederneschi N, Sesenna E. Adenoid cystic carcinoma of intraoral minor salivary glands. Oral Oncol. 2008;44:1026-31 pubmed publisher
    ..We present a retrospective multicentric study of 67 patients with adenoid cystic carcinomas of the intraoral minor salivary glands, who were diagnosed and treated between 1986 and 2004 in the Operative Units of Maxillofacial Surgery of ..
  5. Morawietz L, Martinez Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, et al. Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. J Rheumatol. 2009;36:2694-703 pubmed publisher
    ..Minor salivary gland specimens were analyzed to investigate dysregulation of the proteasome system in patients with Sjögren's syndrome (SS) and patients with sicca syndrome...
  6. Kimura T, Fukui H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, et al. Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjögren's syndrome. Clin Exp Immunol. 2009;155:16-20 pubmed publisher
    ..Moreover, these labelling indices were significantly higher in REG Ialpha-positive than in negative SS patients. REG Ialpha protein may play a role in the regeneration of ductal epithelial cells in the MSGs of patients with SS...
  7. Shoji N, Sasano T, Inukai K, Satoh Kuriwada S, Iikubo M, Furuuchi T, et al. A simple, yet accurate method for detecting and quantifying secretions from human minor salivary glands using the iodine-starch reaction. Arch Oral Biol. 2003;48:761-5 pubmed
    The lack of published information about the minor salivary glands is due in part to the difficulties experienced in collecting and quantifying their secretions...
  8. Jayakrishnan A, Elmalah I, Hussain K, Odell E. Basal cell adenocarcinoma in minor salivary glands. Histopathology. 2003;42:610-4 pubmed
    ..Basal cell adenocarcinoma is very rarely reported in minor salivary glands. We report three cases of basal cell adenocarcinoma affecting the labial, buccal and palatal minor ..
  9. Cwalina P, Skorek A, Narozny W, Stankiewicz C. [Pleomorphic adenoma of minor salivary glands]. Otolaryngol Pol. 2002;56:737-40 pubmed
    ..The clinical and pathological features of these patients are presented. Special attention is given to malignant transformation and the rate of recurrence of the tumors...

More Information

Publications62

  1. Yang S, Li L, Zeng M, Zhu X, Zhang J, Chen X. Myoepithelial carcinoma of intraoral minor salivary glands: a clinicopathological study of 7 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:85-93 pubmed publisher
    ..We present the clinicopathological and immunohistochemical features of 7 cases of intraoral MC in attempt to better understanding this entity...
  2. Buchner A, Merrell P, Carpenter W. Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med. 2007;36:207-14 pubmed
    ..The aim of this study was to determine the relative frequency and distribution of IMSGT in an oral pathology biopsy service and to compare the data with similar studies from different parts of the world...
  3. Shahsavari F, Eslami M, Baghaie F, Tirgari F, Motahhary P. Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. Asian Pac J Cancer Prev. 2005;6:527-30 pubmed
    ..p27 expression was investigated in pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs) of minor salivary glands to evaluate its utility for differentiation purposes...
  4. Batbayar B, Nagy G, Kovesi G, Zelles T, Feher E. Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren's syndrome. Arch Oral Biol. 2004;49:529-38 pubmed
    ..Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS...
  5. Radfar L, Kleiner D, Fox P, Pillemer S. Prevalence and clinical significance of lymphocytic foci in minor salivary glands of healthy volunteers. Arthritis Rheum. 2002;47:520-4 pubmed
    To determine the prevalence and severity of focal lymphocytic sialadenitis in minor salivary glands of healthy, asymptomatic individuals, in whom Sjögren's syndrome (SS) has been excluded.
  6. Martins M, Cavalcanti de Araujo V, Raitz R, Soares de Araújo N. Expression of cytoskeletal proteins in developing human minor salivary glands. Eur J Oral Sci. 2002;110:316-21 pubmed
    ..CKs) 7,8,10,13,14,16,18 and 19, vimentin (VIM), and smooth muscle actin (SMA) in developing human minor salivary glands using monoclonal antibodies...
  7. Curran A, White D, Damm D, Murrah V. Polymorphous low-grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary acidic protein. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:194-9 pubmed
    ..The objective of this study was to determine whether differential expression of GFAP in these 2 tumors could be diagnostically significant...
  8. Alborghetti M, Correa M, Adam R, Metze K, Coracin F, De Souza C, et al. Late effects of chronic graft-vs.-host disease in minor salivary glands. J Oral Pathol Med. 2005;34:486-93 pubmed
    ..The established pathologic criteria for minor salivary gland (MSG) involvement in chronic graft-vs.-host disease (cGVHD) could play a role in monitoring response to therapy...
  9. Sengupta A, Valdramidou D, Huntley S, Hicks S, Carrington S, Corfield A. Distribution of MUC1 in the normal human oral cavity is localized to the ducts of minor salivary glands. Arch Oral Biol. 2001;46:529-38 pubmed
    ..ducts of normal parotid and submandibular gland, and our findings demonstrate a similar distribution in minor salivary glands. We conclude that when present in the normal oral glycocalyx, the only oral source of MUC1 is from cell ..
  10. Copelli C, Bianchi B, Ferrari S, Ferri A, Sesenna E. Malignant tumors of intraoral minor salivary glands. Oral Oncol. 2008;44:658-63 pubmed
    ..2%, 83.4%, and 57.5%, respectively. The T stage, cervical lymph node metastasis, surgical margin status and perineural invasion were statistically significant to the outcome...
  11. Chen K. Intraductal carcinoma of the oral cavity. Am J Surg Pathol. 2005;29:279; author reply 279 pubmed
  12. Al Hashimi I, Wright J, Cooley C, Nunn M. Reproducibility of biopsy grade in Sjögren's syndrome. J Oral Pathol Med. 2001;30:408-12 pubmed
    ..001). The overall result of this study suggests that examination of multiple sections of minor salivary gland biopsies is advisable to improve the reliability of the grade when evaluating Sjögren's syndrome...
  13. Rahman B, Mamoon N, Jamal S, Zaib N, Luqman M, Mushtaq S, et al. Malignant tumors of the minor salivary glands in northern Pakistan: a clinicopathological study. Hematol Oncol Stem Cell Ther. 2008;1:90-3 pubmed
    Malignant tumors of the minor salivary glands comprise a small but significant proportion of oral cancers. We analyzed this group of tumors in our population.
  14. Jonsson M, Skarstein K. Follicular dendritic cells confirm lymphoid organization in the minor salivary glands of primary Sjögren's syndrome. J Oral Pathol Med. 2008;37:515-21 pubmed publisher
    ..The aim of this study was to explore immunophenotypic features of chronic inflammatory reactions in the minor salivary glands in patients with primary SS (pSS).
  15. Vered M, Daniel N, Hirshberg A, Dayan D. Histomorphologic and morphometric changes in minor salivary glands of the rat tongue during 4-nitroquinoline-1-oxide-induced carcinogenesis. Oral Oncol. 2003;39:491-6 pubmed
    ..Aim of study was to investigate histomorphologic and morphometric 4NQO-induced changes in tongue minor salivary glands. Histopathological examinations of serous and mucous acini and ducts of tongue salivary glands of 26 ..
  16. Strick M, Kelly C, Soames J, McLean N. Malignant tumours of the minor salivary glands--a 20 year review. Br J Plast Surg. 2004;57:624-31 pubmed
    The UK incidence of malignant disease of the minor salivary glands is only 0.6 per million per year. The tumours have a varied histology, can present in any age group and are frequently advanced if located in the sinonasal cavities...
  17. Cerulli G, Renzi G, Perugini M, Becelli R. Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate. J Craniofac Surg. 2004;15:1056-60 pubmed
    Tumors arising from minor salivary glands of the palate may exhibit an overlap of clinical and biologic features that may produce diagnostic and therapeutic dilemmas...
  18. Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, et al. Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg. 2005;34:528-32 pubmed
  19. Jones A, Craig G, Speight P, Franklin C. The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol. 2008;44:407-17 pubmed
    ..These data were then analysed for the distribution of benign and malignant salivary tumours in major and minor salivary glands. 58,880 specimens were received; of these, 741 cases (1...
  20. Ek M, Popovic K, Harris H, Nauclér C, Wahren Herlenius M. Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 2006;54:2289-94 pubmed
    ..To investigate the expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the salivary glands of patients with Sjögren's syndrome (SS) and patients with sicca symptoms...
  21. Kaneda Y, Yamaai T, Mizukawa N, Nagatsuka H, Yamachika E, Gunduz M, et al. Localization of antimicrobial peptides human beta-defensins in minor salivary glands with Sjögren's syndrome. Eur J Oral Sci. 2009;117:506-10 pubmed publisher
    ..Because of the presence of inflammation, we hypothesized that human beta-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome...
  22. Lourenço S, Uyekita S, Lima D, Soares F. Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation. Virchows Arch. 2008;452:427-34 pubmed
    ..The data suggest that TGF-beta have a role to play in salivary gland development and differentiation...
  23. Blanco M, Mesko T, Cura M, Cabello Inchausti B. Chronic sclerosing sialadenitis (Kuttner's tumor): unusual presentation with bilateral involvement of major and minor salivary glands. Ann Diagn Pathol. 2003;7:25-30 pubmed
    ..We report an unusual case of chronic sclerosing sialadenitis, affecting both parotid glands, both submandibular glands, and minor salivary glands of the oral cavity, and explore the immunohistochemical profile of this entity.
  24. Barcellos K, Nonogaki S, Enokihara M, Teixeira M, Andrade L. Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome. J Rheumatol. 2007;34:1283-92 pubmed
    To analyze the protein and messenger RNA (mRNA) expression of La/SSB, Ro/SSA 60, and Ro/SSA 52 antigens in minor salivary glands (MSG) from patients with primary Sjögren's syndrome (pSS).
  25. de Camargo Moraes P, Bonecker M, Furuse C, Thomaz L, Teixeira R, de Araujo V. Mucocele of the gland of Blandin-Nuhn: histological and clinical findings. Clin Oral Investig. 2009;13:351-3 pubmed publisher
    ..Histopathologically, the mucoceles were of the extravasation type and trauma might be the most frequent etiological factor. This type of mucocele was the second most frequent one and should not be considered rare...
  26. Jaber M. Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg. 2006;35:150-4 pubmed
    ..This study shows that intraoral tumors of minor salivary glands vary widely in presentation, and should be taking into account by medical and dental practitioners in any ..
  27. Chen A, Garcia J, Lee N, Bucci M, Eisele D. Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation?. Int J Radiat Oncol Biol Phys. 2007;67:988-94 pubmed
    ..To evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (ENI)...
  28. Parashar P, Baron E, Papadimitriou J, Ord R, Nikitakis N. Basal cell adenocarcinoma of the oral minor salivary glands: review of the literature and presentation of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:77-84 pubmed
    ..Here we present 2 cases of BCA arising in the minor salivary glands of the left cheek and junction of the hard and soft palate, respectively...
  29. Soares A, Faria P, Magna L, Correa M, de Sousa C, Almeida O, et al. Chronic GVHD in minor salivary glands and oral mucosa: histopathological and immunohistochemical evaluation of 25 patients. J Oral Pathol Med. 2005;34:368-73 pubmed
    ..Host Disease (cGVHD) in oral mucosa and minor salivary glands of 25 patients, as well as to evaluate the immunophenotype of the inflammatory cells.
  30. Fernandes J, Nico M, Aoki V, Bologna S, Romiti R, Levy Neto M, et al. Xerostomia in Sjögren's syndrome and lupus erythematosus: a comparative histological and immunofluorescence study of minor salivary glands alterations. J Cutan Pathol. 2010;37:432-8 pubmed publisher
    ..The present study compared histopathological and direct immunofluorescence (DIF) alterations in salivary glands of patients with xerostomia and diagnosis of LE or SS...
  31. Vivino F, Gala I, Hermann G. Change in final diagnosis on second evaluation of labial minor salivary gland biopsies. J Rheumatol. 2002;29:938-44 pubmed
    ..We evaluated the diagnostic accuracy of labial salivary gland specimens from a group of patients with symptoms or signs of dry mouth and/or dry eyes referred for assessment of possible Sjögren's syndrome (SS)...
  32. Baurmash H. Mucoceles and ranulas. J Oral Maxillofac Surg. 2003;61:369-78 pubmed
  33. Mucke T, Robitzky L, Kesting M, Wagenpfeil S, Holhweg Majert B, Wolff K, et al. Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:81-9 pubmed publisher
    ..Intraoral minor salivary gland carcinomas (MSGC) are rare tumors with different frequency, distribution, and prognostic factors relating to overall survival...
  34. Hand A, Pathmanathan D, Field R. Morphological features of the minor salivary glands. Arch Oral Biol. 1999;44 Suppl 1:S3-10 pubmed
    The minor salivary glands are important components of the oral cavity, present in most parts of the mouth, and their secretions directly bathe the tissues...
  35. Andersen L, Therkildsen M, Ockelmann H, Bentzen J, Schiødt T, Hansen H. Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results. Cancer. 1991;68:2431-7 pubmed
    Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed...
  36. Sahasrabudhe K, Kimball J, Morton T, Weinberg A, Dale B. Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. J Dent Res. 2000;79:1669-74 pubmed
    ..Association of hBD-1 with salivary mucin may facilitate peptide distribution and adherence to oral surfaces and aid its function within the oral cavity...
  37. Basu D, Williams F, Ahn C, Reveille J. Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. Arthritis Rheum. 2006;55:466-72 pubmed
  38. Piludu M, Lantini M, Isola M, Puxeddu R, Cossu M. Localisation of epidermal growth factor receptor in mucous cells of human salivary glands. Eur J Morphol. 2003;41:107-9 pubmed
    ..this paper, we describe the ultrastructural localisation of EGFR in the mucous elements of human major and minor salivary glands and relate it to mucin distribution...
  39. Li Y, He Z, Liu L, He H. [A retrospective study on 615 cases of minor salivary gland tumors]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2004;22:204-6 pubmed
    ..To analyse the clinical and pathological characteristics of minor salivary gland tumors...
  40. Webster Cyriaque J. Development of Kaposi's sarcoma in a surgical wound. N Engl J Med. 2002;346:1207-10 pubmed
  41. Wheeler T, Haigh B, McCracken J, Wilkins R, Morris C, Grigor M. The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. Biochim Biophys Acta. 2002;1579:92-100 pubmed
    ..Furthermore, they imply that the BSP30a and BSP30b proteins may have a function in common with other members of this gene family...
  42. Smith S, Shneider B, Magid M, Martin G, Rothschild M. Minor salivary gland biopsy in neonatal hemochromatosis. Arch Otolaryngol Head Neck Surg. 2004;130:760-3 pubmed
    ..However, ready diagnosis remains a problem. A liver biopsy specimen showing siderosis is not specific for hemochromatosis and may be risky in patients with coagulopathy...
  43. Silva A, Silva C, Furuse C, Nunes e Souza R, da Costa M, de Araujo V. Necrotizing sialometaplasia in a patient who is HIV positive: a case report. Spec Care Dentist. 2010;30:160-2 pubmed publisher
    Necrotizing sialometaplasia (NS) is a self-limiting, benign, inflammatory disease of the minor salivary glands of the hard palate...
  44. Gonzalez Lagunas J, Rodado C, Raspall G, Bermejo B, Huguet P, Giralt J. Malignant tumors of the minor salivary glands. Retrospective study on 59 cases. Med Oral. 2001;6:142-7 pubmed
    b>Minor salivary glands cancer account for 2-4% of head and neck cancer, 10% of all oral cavity cancer and 15-23% of all salivary glands cancer (1)...
  45. Amft N, Curnow S, Scheel Toellner D, Devadas A, Oates J, Crocker J, et al. Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum. 2001;44:2633-41 pubmed
  46. Sahai K, Kapila K, Dahiya S, Verma K. Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 2002;13:309-16 pubmed
    ..Palatal salivary gland tumours, although relatively uncommon, are difficult to diagnose cytologically. This is more so in cases of newer entities such as PLGA, as their cytological diagnosis is still not well characterized...
  47. Teng M, Genden E, Buchbinder D, Urken M. Subcutaneous mandibulotomy: a new surgical access for large tumors of the parapharyngeal space. Laryngoscope. 2003;113:1893-7 pubmed
    ..We describe a new technique to gain exposure to the PPS while avoiding these consequences...
  48. Mahajan D, Khurana N, Setia N. Sialadenoma papilliferum in a young patient: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e51-4 pubmed
    ..This case highlights the importance of keeping sialadenoma papilliferum as a differential diagnosis of an intraoral exophytic proliferative lesion even in a young patient...
  49. Yang S, Zhang J, Chen X, Wang L, Xie F. Clear cell carcinoma, not otherwise specified, of salivary glands: a clinicopathologic study of 4 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:712-20 pubmed publisher
    ..It arises primarily in the minor salivary glands (91% of cases), particularly in the palate or base of tongue, and usually occurs in patients >30 years ..
  50. Desai S, Borges A. Melanin bearing myoepithelial cells in a pigmented salivary gland carcinoma: a new avatar of myoepithelial cell? A case report. Virchows Arch. 2006;448:521-3 pubmed
    ..The myoepithelial cells of this tumor contained melanin pigment. The possible histogenesis of this lesion and an explanation for the occurrence of melanin pigment in a salivary gland tumor are discussed...
  51. Takeda Y, Kurose A. Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors. J Oral Sci. 2006;48:253-6 pubmed
    ..The possible histogenesis of melanocytes in the salivary gland lesions is discussed, although no firm conclusion could be drawn...
  52. Javed A, Balabanov R, Arnason B, Kelly T, Sweiss N, Pytel P, et al. Minor salivary gland inflammation in Devic's disease and longitudinally extensive myelitis. Mult Scler. 2008;14:809-14 pubmed publisher
    ..A high percentage of patients with Sjögren's disease have inflammatory infiltrates in minor salivary glands, and this may be a reliable indicator of early or subclinical disease...
  53. Båve U, Nordmark G, Lövgren T, Ronnelid J, Cajander S, Eloranta M, et al. Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum. 2005;52:1185-95 pubmed
    ..In other autoimmune diseases, type I interferon (IFN) may play a pivotal role by triggering and sustaining the disease process. We therefore aimed to determine whether patients with primary SS had an activated type I IFN system...