lacrimal apparatus

Summary

Summary: The tear-forming and tear-conducting system which includes the lacrimal glands, eyelid margins, conjunctival sac, and the tear drainage system.

Top Publications

  1. Ding C, Lu M, Huang J. Na(+)/K(+)-ATPase in the lacrimal glands of rabbits and its changes during induced autoimmune dacryoadenitis. Mol Vis. 2011;17:2368-79 pubmed
    ..To test the hypothesis that expression of Na(+)/K(+)-ATPase subunits in the lacrimal glands (LGs) of rabbits with induced autoimmune dacryoadenitis (IAD) changes...
  2. Nishida T, Chikama T, Sawa M, Miyata K, Matsui T, Shigeta K. Differential contributions of impaired corneal sensitivity and reduced tear secretion to corneal epithelial disorders. Jpn J Ophthalmol. 2012;56:20-5 pubmed publisher
    ..To determine the possible roles of impaired corneal sensitivity and reduced tear secretion in various types of corneal epithelial disorders...
  3. Morimoto Tochigi A, Walkup R, Nakajima E, Shearer T, Azuma M. Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells. Invest Ophthalmol Vis Sci. 2010;51:4395-406 pubmed publisher
    ..Induction of transcription by Cch involved the independent p42/p44 MAPK and PKC pathways...
  4. Meijer J, Meiners P, Vissink A, Spijkervet F, Abdulahad W, Kamminga N, et al. Effectiveness of rituximab treatment in primary Sjögren's syndrome: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2010;62:960-8 pubmed publisher
    ..To study the efficacy and safety of B cell depletion with rituximab, a chimeric murine/human anti-CD20 monoclonal antibody, in patients with primary Sjögren's syndrome (SS) in a double-blind, randomized, placebo-controlled trial...
  5. Chiang L, Ngo J, Schechter J, Karvar S, Tolmachova T, Seabra M, et al. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011;301:C507-21 pubmed publisher
    ..These data show that Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release...
  6. Ding C, Nandoskar P, Lu M, Thomas P, Trousdale M, Wang Y. Changes of aquaporins in the lacrimal glands of a rabbit model of Sjögren's syndrome. Curr Eye Res. 2011;36:571-8 pubmed publisher
    ..To test the hypothesis that the expression of aquaporins (AQPs) 4 and 5 is altered in the lacrimal glands (LG) of rabbits with induced autoimmune dacryoadenitis (IAD)...
  7. Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt T, et al. Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011;286:14435-44 pubmed publisher
    ..To our knowledge, this is the first study to show that simultaneous deletion of Hs2st and Hs6st exhibits profound FGF signaling defects in mammalian development...
  8. Pitcher J, de Paiva C, Pelegrino F, McClellan A, Raince J, Pangelinan S, et al. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011;52:3221-7 pubmed publisher
    ..To investigate the effects of cholinergic blockade on inflammatory cell infiltration and cytokine production in the mouse lacrimal gland (LG)...
  9. Higuchi A, Takahashi K, Hirashima M, Kawakita T, Tsubota K. Selenoprotein P controls oxidative stress in cornea. PLoS ONE. 2010;5:e9911 pubmed publisher
    ..Collectively, we concluded that tear SeP is a key molecule to protect the ocular surface cells against environmental oxidative stress...

More Information

Publications62

  1. Kojima T, Wakamatsu T, Dogru M, Ogawa Y, Igarashi A, Ibrahim O, et al. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol. 2012;180:1879-96 pubmed publisher
    ..Our results suggest that Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated lacrimal gland alterations...
  2. Li X, Wu K, Edman M, Schenke Layland K, MacVeigh Aloni M, Janga S, et al. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010;51:5019-29 pubmed publisher
    ..Differentially expressed genes were further investigated at the protein level to correlate changes in location and abundance with development of disease...
  3. Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X. Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 2012;139:2730-9 pubmed publisher
    ..Taken together, these results demonstrate that mesenchymal GAG controls lacrimal gland induction by restricting the diffusion of Fgf10...
  4. Yaguchi S, Ogawa Y, Shimmura S, Hatou S, Nakamura S, Inaba T, et al. Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2012;53:5416-25 pubmed publisher
    ..To investigate the expression, localization, and physiologic function of renin-angiotensin system (RAS) components in the mouse lacrimal gland...
  5. Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H, et al. Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS ONE. 2010;5:e11119 pubmed publisher
    ..To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study...
  6. Chen Z, Liang Q, Yu G. Establishment of a rabbit model for keratoconjunctivitis sicca. Cornea. 2011;30:1024-9 pubmed publisher
    ..To establish a rabbit model for keratoconjunctivitis sicca (KCS) to study autologous submandibular gland transfer for treating severe KCS...
  7. Schechter J, Warren D, Mircheff A. A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human. Ocul Surf. 2010;8:111-34 pubmed
    ..In addition, comparisons with relevant aspects of the human lacrimal gland are included where permitted by available data. ..
  8. Kawashima M, Kawakita T, Okada N, Ogawa Y, Murat D, Nakamura S, et al. Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats. Biochem Biophys Res Commun. 2010;397:724-8 pubmed publisher
    ..Although molecular mechanism(s) by which CR maintains lacrimal gland function remains to be resolved, CR might provide a novel therapeutic strategy for treating dry eye syndrome...
  9. Garreis F, Gottschalt M, Schlorf T, Gläser R, Harder J, Worlitzsch D, et al. Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus. Invest Ophthalmol Vis Sci. 2011;52:4914-22 pubmed publisher
    ..The purpose of this study was to investigate the expression and antimicrobial role of psoriasin at the ocular surface and in the lacrimal apparatus.
  10. Tint N, Alexander P, Cook A, Leatherbarrow B. Eyelid avulsion repair with bi-canalicular silicone stenting without medial canthal tendon reconstruction. Br J Ophthalmol. 2011;95:1389-92 pubmed publisher
  11. Leibovitch I, Kakizaki H, Prabhakaran V, Selva D. Canalicular lacerations: repair with the Mini-Monoka® monocanalicular intubation stent. Ophthalmic Surg Lasers Imaging. 2010;41:472-7 pubmed publisher
    ..There are different techniques for reconstructing traumatic canalicular lacerations. The aim of this study is to report the surgical outcome with the Mini-Monoka monocanalicular stent (FCI Ophthalmics, Issy-Les Moulineaux, France)...
  12. Robbins A, Kurose M, Winterson B, Meng I. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Invest Ophthalmol Vis Sci. 2012;53:7034-42 pubmed publisher
    ..The purpose of our study was to determine whether menthol induces corneal cool cell activity and lacrimation via the transient receptor potential melastatin-8 (TRPM8) channel without evoking nociceptive responses...
  13. Tiwari S, Ali M, Balla M, Naik M, Honavar S, Reddy V, et al. Establishing human lacrimal gland cultures with secretory function. PLoS ONE. 2012;7:e29458 pubmed publisher
    ..This study aimed to establish functionally competent lacrimal gland cultures in-vitro and explore the presence of stem cells in the native gland and the established in-vitro cultures...
  14. You S, Kublin C, Avidan O, Miyasaki D, Zoukhri D. Isolation and propagation of mesenchymal stem cells from the lacrimal gland. Invest Ophthalmol Vis Sci. 2011;52:2087-94 pubmed publisher
    ..The aim of the present study was to determine whether these cells can be isolated from the lacrimal gland and propagated in vitro...
  15. Zoukhri D. Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cells. Ocul Surf. 2010;8:60-9 pubmed
    ..This article reviews recent advances in exocrine tissue injury and repair, with emphasis on the roles of programmed cell death and stem/progenitor cells. ..
  16. Hosaka E, Kawamorita T, Ogasawara Y, Nakayama N, Uozato H, Shimizu K, et al. Interferometry in the evaluation of precorneal tear film thickness in dry eye. Am J Ophthalmol. 2011;151:18-23.e1 pubmed publisher
    ..To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry...
  17. Higuchi A, Ito K, Dogru M, Kitamura M, Mitani F, Kawakita T, et al. Corneal damage and lacrimal gland dysfunction in a smoking rat model. Free Radic Biol Med. 2011;51:2210-6 pubmed publisher
    ..Although the influence of other components in MCS remains unclear, CYPs, especially CYP1A1, probably participate in corneal damage and lacrimal gland dysfunction induced by smoking...
  18. Jäger K, Wu G, Sel S, Garreis F, Bräuer L, Paulsen F. MUC16 in the lacrimal apparatus. Histochem Cell Biol. 2007;127:433-8 pubmed
    The aim of the present study was to determine the possible expression of the mucin MUC16 in the lacrimal apparatus. Expression and distribution of MUC16 in lacrimal gland, accessory lacrimal glands, and nasolacrimal ducts was monitored by ..
  19. Hakim S, Schroder C, Geerling G, Lauer I, Wedel T, Kosmehl H, et al. Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lachrymal gland following external beam radiation. Int J Exp Pathol. 2006;87:65-71 pubmed
    ..These changes may represent objective surrogate parameters for radiogenic dysfunction and prerequisites for further investigations on radioprotection of lachrymal glands during radiotherapy of the periorbital region...
  20. Konno A, Takada K, Saegusa J, Takiguchi M. Presence of B7-2+ dendritic cells and expression of Th1 cytokines in the early development of sialodacryoadenitis in the IqI/Jic mouse model of primary Sjörgren's syndrome. Autoimmunity. 2003;36:247-54 pubmed
    ..It is also likely that Th1 cytokines mediate the functional interactions between the APCs and CD4+ T cells in the early lesions...
  21. Richards S, Liu M, Jensen R, Schirra F, Yamagami H, Lombardi M, et al. Androgen regulation of gene expression in the mouse lacrimal gland. J Steroid Biochem Mol Biol. 2005;96:401-13 pubmed
    ..Overall, these results support our working hypothesis that androgen action on the lacrimal gland is mediated primarily through a receptor-associated regulation of gene transcription...
  22. Zhu L, Shen J, Zhang C, Park C, Kohanim S, Yew M, et al. Inflammatory cytokine expression on the ocular surface in the Botulium toxin B induced murine dry eye model. Mol Vis. 2009;15:250-8 pubmed
    ..Inflammation plays an important role in dry eye syndrome. In this study, inflammatory cytokine expression on the ocular surface in the Botulium toxin B (BTX-B) induced mouse dry eye model was investigated...
  23. Long L, Liu Z, Wang T, Deng X, Yang K, Li L, et al. Polyethersulfone dead-end tube as a scaffold for artificial lacrimal glands in vitro. J Biomed Mater Res B Appl Biomater. 2006;78:409-16 pubmed
    ..Thus, PES is a substrate for the growth of lacrimal acinar cells and may be a useful scaffolding biomaterial for tissue engineering, such as a scaffold for artificial lacrimal glands...
  24. Jerdeva G, Wu K, Yarber F, Rhodes C, Kalman D, Schechter J, et al. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005;118:4797-812 pubmed
  25. Pang C, Brown J, Ganote C, Youngberg G. A mass of the right lacrimal sac in a 53-year-old man. Arch Pathol Lab Med. 2005;129:1493-4 pubmed
  26. Dias A, Módulo C, Jorge A, Braz A, Jordao A, Filho R, et al. Influence of thyroid hormone on thyroid hormone receptor beta-1 expression and lacrimal gland and ocular surface morphology. Invest Ophthalmol Vis Sci. 2007;48:3038-42 pubmed
  27. Kimoto H, Haga S, Sato K, Touhara K. Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons. Nature. 2005;437:898-901 pubmed
    ..Our results indicate that mice respond to sex-specific peptides released from exocrine glands through the vomeronasal system during direct contact...
  28. Entesarian M, Dahlqvist J, Shashi V, Stanley C, Falahat B, Reardon W, et al. FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG). Eur J Hum Genet. 2007;15:379-82 pubmed
    ..The clinical features of these patients further broaden the knowledge of FGF10-related phenotypes...
  29. Evans E, Zhang W, Jerdeva G, Chen C, Chen X, Hamm Alvarez S, et al. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008;294:C662-74 pubmed publisher
    ..These data suggest that the novel localization of pIgR to the regulated secretory pathway of LGACs and its secretion therefrom may be affected by its novel interaction with Rab3D...
  30. Suwan Apichon O, Rizen M, Rangsin R, Herretes S, Reyes J, Lekhanont K, et al. Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2006;47:133-9 pubmed
    ..To develop a mouse model of human chronic dry eye (keratoconjunctivitis sicca [KCS])...
  31. Roh J, Kim J. Küttner's tumor: unusual presentation with bilateral involvement of the lacrimal and submandibular glands. Acta Otolaryngol. 2005;125:792-6 pubmed
    ..There was no evidence of lymphoepithelial lesions or intraepithelial lymphocytes. This is the first case of KT involving both lacrimal and submandibular glands, suggesting that KT is closely related to an active local immune process...
  32. Ishida R, Kojima T, Dogru M, Kaido M, Matsumoto Y, Tanaka M, et al. The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Am J Ophthalmol. 2005;139:253-8 pubmed
    ..To evaluate the efficacy of a new continuous functional visual acuity measurement (FVAM) system for the assessment of dry eye patients...
  33. Manganelli P, Fietta P. Apoptosis and Sjögren syndrome. Semin Arthritis Rheum. 2003;33:49-65 pubmed
  34. Da Costa S, Andersson S, Arber F, Okamoto C, HAMM ALVAREZ S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002;506:199-205 pubmed
  35. Yu D, Chen Y, Han J, Zhang H, Chen X, Zou W, et al. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients. Exp Eye Res. 2008;86:403-11 pubmed publisher
  36. Tsirbas A, Wormald P. Mechanical endonasal dacryocystorhinostomy with mucosal flaps. Br J Ophthalmol. 2003;87:43-7 pubmed
    ..This is a new technique that involves creation of a large rhinostomy and mucosal flaps. The study involved a prospective non-randomised interventional case series with short perioperative follow up...
  37. Sasaki Y, Tsubota K, Kawedia J, Menon A, Yasui M. The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands. Curr Eye Res. 2007;32:923-9 pubmed
    ..This study was designed to clarify the physiological function and tissue distribution of aquaporin 5 (AQP5) in the lacrimal and parotid glands...
  38. Draper C, Singh J, Adeghate E. Effects of age on morphology, protein synthesis and secretagogue-evoked secretory responses in the rat lacrimal gland. Mol Cell Biochem. 2003;248:7-16 pubmed
    ..However, all responses to the secretagogues were reduced with ageing from 3-5 to 24 months of age. The results indicate that ageing is associated with alteration in the ability of acinar cells to synthesise and secrete proteins...
  39. Doyle M, Boggs L, Attia R, Cooper L, Saban D, Nguyen C, et al. Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. Am J Pathol. 2007;171:1224-36 pubmed
    ..Thus, using this model we can identify potentially important pathophysiological mechanisms of the autoimmune attack and possible diagnostic markers for development of SjS-associated dacryoadenitis...
  40. Shams I, Rohmann E, Eswarakumar V, Lew E, Yuzawa S, Wollnik B, et al. Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Mol Cell Biol. 2007;27:6903-12 pubmed
  41. de Paiva C, Hwang C, Pitcher J, Pangelinan S, Rahimy E, Chen W, et al. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010;49:246-58 pubmed publisher
    ..The objective of this study was to evaluate the severity of corneal epithelial disease and T-cell cytokine profile in the ocular surface tissues of CD25KO mice...
  42. Zoukhri D. Effect of inflammation on lacrimal gland function. Exp Eye Res. 2006;82:885-98 pubmed
  43. Chastain J, Sindwani R. Anatomy of the orbit, lacrimal apparatus, and lateral nasal wall. Otolaryngol Clin North Am. 2006;39:855-64, v-vi pubmed
    ..The structural features of the lateral nasal wall and medial orbit are highlighted, and relevant aspects of orbital, lacrimal, and paranasal sinus anatomy are reviewed...
  44. Zhu Z, Stevenson D, Schechter J, Mircheff A, Atkinson R, Trousdale M. Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003;22:25-32 pubmed
    ..To study the effects of induced autoimmune dacryoadenitis on lacrimal gland function, histopathology, and ocular surface disease in a rabbit model...
  45. Ogawa Y, Kuwana M, Yamazaki K, Mashima Y, Yamada M, Mori T, et al. Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease. Invest Ophthalmol Vis Sci. 2003;44:1888-96 pubmed
    ..To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation...
  46. Stern M, Gao J, Siemasko K, Beuerman R, Pflugfelder S. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004;78:409-16 pubmed
    ..Factors such as neurogenic inflammation and T cell involvement in the disease pathogenesis as well as newly developed animal models of ocular surface inflammation are discussed...
  47. Rehorek S, Legenzoff E, Carmody K, Smith T, Sedlmayr J. Alligator tears: a reevaluation of the lacrimal apparatus of the crocodilians. J Morphol. 2005;266:298-308 pubmed
    ..Little is known about the lacrimal apparatus of the crocodilians...
  48. Alves M, Cunha D, Calegari V, Saad M, Boschero A, Velloso L, et al. Nuclear factor-kappaB and advanced glycation end-products expression in lacrimal glands of aging rats. J Endocrinol. 2005;187:159-66 pubmed
    ..These observations indicate that metabolic events may be related to LG and tear film dysfunctions in aging...
  49. Niederkorn J, Stern M, Pflugfelder S, de Paiva C, Corrales R, Gao J, et al. Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006;176:3950-7 pubmed
  50. Xie J, Chiang L, Contreras J, Wu K, Garner J, Medina Kauwe L, et al. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006;80:11833-51 pubmed
  51. Toshida H, Nguyen D, Beuerman R, Murakami A. Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit. Invest Ophthalmol Vis Sci. 2007;48:4468-75 pubmed
    ..To evaluate ocular surface status after interruption of preganglionic, parasympathetic neural control after surgical removal of the greater superficial petrosal nerve (GSPN)...
  52. Thomas P, Zhu Z, Selvam S, Samant D, Stevenson D, Mircheff A, et al. Autoimmune dacryoadenitis and keratoconjunctivitis induced in rabbits by subcutaneous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. J Autoimmun. 2008;31:116-22 pubmed publisher
  53. Herok G, Millar T, Anderton P, Martin D. Role of chloride channels in regulating the volume of acinar cells of the rabbit superior lacrimal gland. Invest Ophthalmol Vis Sci. 2008;49:5517-25 pubmed publisher
    ..To characterize the outward chloride currents (Cl(OR)) in single acinar cells isolated from the rabbit superior lacrimal gland (RSLG) to investigate the hypothesis that Cl(OR) may have a role in regulating the volume of RSLG acini...