Summary: Jelly-like connective tissue of the UMBILICAL CORD that contains MESENCHYMAL STROMAL CELLS.
Huang Y, Parolini O, La Rocca G, Deng L. Umbilical cord versus bone marrow-derived mesenchymal stromal cells. Stem Cells Dev. 2012;21:2900-3 pubmed publisher
Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, et al
. Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells. Stem Cell Res Ther. 2013;4:59 pubmed publisher
..Induction of native and foreign HGF synthesis in damaged TECs at the initial stage of AKI leads to recovery of the disturbed balance of HGF/TGF-?1 during scar formation, being one of the vital mechanisms. ..
Arno A, Amini Nik S, Blit P, Al Shehab M, Belo C, Herer E, et al
. Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling. Stem Cell Res Ther. 2014;5:28 pubmed publisher
..001) and migration (P?0.05), and promoted wound healing in an excisional full-thickness skin murine model. Under our experimental conditions, WJ-MSCs enhanced skin wound healing in an in vivo mouse model. ..
Zou X, Zhang G, Cheng Z, Yin D, Du T, Ju G, et al
. Microvesicles derived from human Wharton's Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1. Stem Cell Res Ther. 2014;5:40 pubmed publisher
..This establishes a substantial foundation for future research and treatment. ..
Liu S, Jia Y, Yuan M, Guo W, Huang J, Zhao B, et al
. Repair of Osteochondral Defects Using Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells in a Rabbit Model. Biomed Res Int. 2017;2017:8760383 pubmed publisher
..hWJMSC allografts may be promising for clinical applications. ..
Aleksander Konert E, Paduszyński P, Zajdel A, Dzierzewicz Z, Wilczok A. In vitro chondrogenesis of Wharton's jelly mesenchymal stem cells in hyaluronic acid-based hydrogels. Cell Mol Biol Lett. 2016;21:11 pubmed publisher
..The results indicate that WJ-MSCs have some degree of chondrogenic potential in HyStem and HyStem-C hydrogels, showing promise for the engineering of damaged articular cartilage. ..
Wang Y, Liu Y, Fan Z, Liu D, Wang F, Zhou Y. IGFBP2 enhances adipogenic differentiation potentials of mesenchymal stem cells from Wharton's jelly of the umbilical cord via JNK and Akt signaling pathways. PLoS ONE. 2017;12:e0184182 pubmed publisher
..Overall, our results reveal a new function of IGFBP2, providing a novel insight into the mechanism of adipogenic differentiation and identifying a potential target mediator for improving adipose tissue engineering based on WJCMSCs. ..
Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, et al
. A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cell Res Ther. 2014;5:57 pubmed publisher
..The therapeutic mechanism may involve improvements in systemic inflammation and/or immunological regulation. Chinese Clinical Trial Register ChiCTR-ONC-10000985. Registered 23 September 2010. ..
Fayyad Kazan M, Najar M, Fayyad Kazan H, Raicevic G, Lagneaux L. Identification and Evaluation of New Immunoregulatory Genes in Mesenchymal Stromal Cells of Different Origins: Comparison of Normal and Inflammatory Conditions. Med Sci Monit Basic Res. 2017;23:87-96 pubmed
..CONCLUSIONS Our observations suggest that these identified immunoregulatory genes may be considered as potential candidates to be targeted in order to enhance the immunomodulatory properties of MSCs towards more efficient clinical use. ..