subcutaneous tissue

Summary

Summary: Loose connective tissue lying under the DERMIS, which binds SKIN loosely to subjacent tissues. It may contain a pad of ADIPOCYTES, which vary in number according to the area of the body and vary in size according to the nutritional state.

Top Publications

  1. Bhake R, Leendertz J, Linthorst A, Lightman S. Automated 24-hours sampling of subcutaneous tissue free cortisol in humans. J Med Eng Technol. 2013;37:180-4 pubmed publisher
    ..The apparatus has the capacity to provide sufficient sample volumes to measure changes in hormone concentration over 24?h, including the important period when subjects are asleep...
  2. Cielecka D, Zarnowska Prymek H, Masny A, Salamatin R, Wesołowska M, Gołab E. Human dirofilariosis in Poland: the first cases of autochthonous infections with Dirofilaria repens. Ann Agric Environ Med. 2012;19:445-50 pubmed
    ..Because of the increasing number of cases of human infections, whether introduced or local, physicians should take dirofilariosis into consideration in differential diagnosis of skin and eye diseases...
  3. Cunha S, Rached F, Alfredo E, Leon J, Perez D. Biocompatibility of sealers used in apical surgery: a histological study in rat subcutaneous tissue. Braz Dent J. 2011;22:299-305 pubmed
    The aim of this study was to evaluate the biocompatibility of sealers used in apical surgery in rat subcutaneous tissue. Sterile polyethylene tubes were filled with the following sealers: Sealapex, Sealapex with addition of zinc oxide, ..
  4. Aguilar F, Roberti Garcia L, Panzeri Pires de Souza F. Biocompatibility of new calcium aluminate cement (EndoBinder). J Endod. 2012;38:367-71 pubmed publisher
    The purpose of this study was to evaluate the biocompatibility of calcium aluminate cement (EndoBinder) in subcutaneous tissue of rats.
  5. Sato Y, Yokoyama A, Nodasaka Y, Kohgo T, Motomiya K, Matsumoto H, et al. Long-term biopersistence of tangled oxidized carbon nanotubes inside and outside macrophages in rat subcutaneous tissue. Sci Rep. 2013;3:2516 pubmed publisher
    ..Biomaterials are typically implanted into subcutaneous tissue or bone; however, the long-term biopersistence of CNTs in these tissues is unknown...
  6. Mach H, Gregory S, Mackiewicz A, Mittal S, Lalloo A, Kirchmeier M, et al. Electrostatic interactions of monoclonal antibodies with subcutaneous tissue. Ther Deliv. 2011;2:727-36 pubmed
    ..There are many potential factors that might influence the absorption, such as charge, hydrophobicity, formulation variables and the depth and volume of the injection...
  7. Qian X, Droste S, Lightman S, Reul J, Linthorst A. Circadian and ultradian rhythms of free glucocorticoid hormone are highly synchronized between the blood, the subcutaneous tissue, and the brain. Endocrinology. 2012;153:4346-53 pubmed publisher
    ..Similar rhythms were also evident in the subcutaneous tissue, demonstrating that free corticosterone rhythms are transferred from the blood into peripheral target ..
  8. Silveira C, Pinto S, Zedebski R, Santos F, Pilatti G. Biocompatibility of four root canal sealers: a histopathological evaluation in rat subcutaneous connective tissue. Braz Dent J. 2011;22:21-7 pubmed
    ..Sealapex induced the lowest inflammatory response at all evaluation periods, and only Pulp Canal Sealer did not show a decreased in the inflammatory reaction over time...
  9. De N, Le T, Chai J. Dirofilaria repens in Vietnam: detection of 10 eye and subcutaneous tissue infection cases identified by morphology and molecular methods. Korean J Parasitol. 2012;50:137-41 pubmed publisher
    ..Ten parasites were recovered either from the conjunctiva (n=9) or subcutaneous tissue (n=1). The parasites were 4.0-12.5 cm in length and 0.5-0.6 mm in width...

Scientific Experts

More Information

Publications62

  1. Mestieri L, Saska S, Carrodeguas R, Gaspar A. Evaluation of n-butyl cyanoacrylate adhesive in rat subcutaneous tissue. Dermatol Surg. 2012;38:767-71 pubmed publisher
    ..Tissue adhesives have been widely used for wound closure, especially in children, because they are painless, fast, and easy to use and result in minimal scarring...
  2. Govinda R, Kasuya Y, Bala E, Mahboobi R, Devarajan J, Sessler D, et al. Early postoperative subcutaneous tissue oxygen predicts surgical site infection. Anesth Analg. 2010;111:946-52 pubmed publisher
    ..However, tissue partial pressure is difficult to measure and requires invasive techniques. We tested the hypothesis that early postoperative tissue oxygen saturation (Sto(2)) measured with near-infrared spectroscopy predicts SSI...
  3. Danesh F, Tootian Z, Jahanbani J, Rabiee M, Fazelipour S, Taghva O, et al. Biocompatibility and mineralization activity of fresh or set white mineral trioxide aggregate, biomimetic carbonated apatite, and synthetic hydroxyapatite. J Endod. 2010;36:1036-41 pubmed publisher
  4. Ohtani M, Nishida N, Chiba T, Muto H, Yoshioka N. Pathological demonstration of rapid involvement into the subcutaneous tissue in a case of fatal hydrofluoric acid burns. Forensic Sci Int. 2007;167:49-52 pubmed
    ..These pathological findings of the skin seen in the present case explain the mechanism behind the rapid dissemination of fluoride ions which entered the bloodstream from damaged arteries, resulting in the development of acute toxicity...
  5. Macchi V, Tiengo C, Porzionato A, Stecco C, Vigato E, Parenti A, et al. Histotopographic study of the fibroadipose connective cheek system. Cells Tissues Organs. 2010;191:47-56 pubmed publisher
    ..9 mm. The connective subcutaneous tissue of the face forms a three-dimensional network connecting the SMAS to the dermis and deep muscles...
  6. Parirokh M, Mirsoltani B, Raoof M, Tabrizchi H, Haghdoost A. Comparative study of subcutaneous tissue responses to a novel root-end filling material and white and grey mineral trioxide aggregate. Int Endod J. 2011;44:283-9 pubmed publisher
    To compare the subcutaneous tissue response to grey mineral trioxide aggregate (GMTA), white mineral trioxide aggregate (WMTA) and a new experimental cement (calcium enriched cement, CEM).
  7. Baradkar V, Mathur M, Kumar S. Phaeohyphomycosis of subcutaneous tissue caused by Phaeoacremonium parasiticum. Indian J Med Microbiol. 2009;27:66-9 pubmed
    ..There were no obvious predisposing factors. The patient was treated with surgical debridement followed by intravenous amphotericin B and itraconazole to which she responded well. We report this case, being rare and the first from India...
  8. Abu Hijleh M, Roshier A, Al Shboul Q, Dharap A, Harris P. The membranous layer of superficial fascia: evidence for its widespread distribution in the body. Surg Radiol Anat. 2006;28:606-19 pubmed
    A discrete membranous layer, "stratum membranosum", in human subcutaneous tissue is classically described as confined to the lower anterior abdominal wall and perineum and referred to as Scarpa's and Colles' fasciae, ..
  9. Rosen N, Hopf H, Hunt T. Perflubron emulsion increases subcutaneous tissue oxygen tension in rats. Wound Repair Regen. 2006;14:55-60 pubmed
    ..this study was that the administration of a perfluorocarbon emulsion, which dissolves oxygen will increase subcutaneous tissue oxygen tension (PsqO2) in normovolemic and hemorrhaged animals...
  10. Miller M, Cheatham C, Holcomb W, Ganschow R, Michael T, Rubley M. Subcutaneous tissue thickness alters the effect of NMES. J Sport Rehabil. 2008;17:68-75 pubmed
    No direct research has been conducted on the relationship between subcutaneous tissue thickness and neuromuscular electrical stimulation (NMES).
  11. Safioleas M, Nikiteas N, Stamatakos M, Safioleas C, Manti C, Revenas C, et al. Echinococcal cyst of the subcutaneous tissue: a rare case report. Parasitol Int. 2008;57:236-8 pubmed publisher
    ..The most common affected organs are the liver and the lungs. Echinococcal cyst located in the subcutaneous tissue constitutes an extremely rare manifestation of the hydatid disease...
  12. Sbidian E, Wolkenstein P, Valeyrie Allanore L, Rodriguez D, Hadj Rabia S, Ferkal S, et al. NF-1Score: a prediction score for internal neurofibromas in neurofibromatosis-1. J Invest Dermatol. 2010;130:2173-8 pubmed publisher
    ..75) in both data sets. The presence of internal neurofibromas can be accurately predicted using a simple clinical score. Further work will establish the score threshold that identifies patients at high risk for complications...
  13. Coutinho Filho T, De Deus G, Klein L, Manera G, Peixoto C, Gurgel Filho E. Radiopacity and histological assessment of Portland cement plus bismuth oxide. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e69-77 pubmed publisher
    ..The present study evaluated the subcutaneous connective tissue reactions and the radiopacity of MTA, Portland cement (PC), and Portland cement plus bismuth oxide (BO)...
  14. Gomes Filho J, Watanabe S, Bernabe P, de Moraes Costa M. A mineral trioxide aggregate sealer stimulated mineralization. J Endod. 2009;35:256-60 pubmed publisher
    The aim of this study was to evaluate the rat subcutaneous tissue response to implanted polyethylene tubes filled with Endo-CPM-Sealer (Portland Cement Modified Sealer) (EGEO S.R.L...
  15. Farina C, Gotti E, Mouniee D, Boiron P, Goglio A. Phaeoacremonium parasiticum subcutaneous infection in a kidney-transplanted patient successfully treated by surgery. Transpl Infect Dis. 2007;9:253-5 pubmed
    ..Six months later, the patient relapsed and underwent large excision. Culture was positive for P. parasiticum. No antifungal drug was administered. Surgical excision was successful...
  16. Langevin H, Bouffard N, Badger G, Churchill D, Howe A. Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism. J Cell Physiol. 2006;207:767-74 pubmed
  17. Camargo S, Rode S, do Prado R, Carvalho Y, Camargo C. Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats. J Appl Oral Sci. 2010;18:273-8 pubmed
    ..Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping...
  18. Korten S, Büttner D, Schmetz C, Hoerauf A, Mand S, Brattig N. The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta). Parasitol Res. 2009;105:731-41 pubmed publisher
    ..Pleomorphic neoplasms in O. volvulus were also labeled. We conclude that latent TGF-beta protein is expressed by filariae independently of Wolbachia, possibly regulating worm tissue homeostasis...
  19. Martínez Lalis R, Esaín M, Kokubu G, Willis J, Chaves C, Grana D. Rat subcutaneous tissue response to modified Portland cement, a new mineral trioxide aggregate. Braz Dent J. 2009;20:112-7 pubmed
    ..Twenty-four male Wistar rats were used. Three silicon tubes were placed on the dorsal subcutaneous tissue of each animal: one tube contained MTA, one tube contained CPM and the other was an empty tube...
  20. Adegbite N, Xu M, Kaplan F, Shore E, Pignolo R. Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification. Am J Med Genet A. 2008;146A:1788-96 pubmed publisher
    ..g., POH) from the non-progressive forms (osteoma cutis, AHO, and PHP1a/c)...
  21. Scarparo R, Haddad D, Acasigua G, Fossati A, Fachin E, Grecca F. Mineral trioxide aggregate-based sealer: analysis of tissue reactions to a new endodontic material. J Endod. 2010;36:1174-8 pubmed publisher
  22. Lotfi M, Vosoughhosseini S, Saghiri M, Mesgariabbasi M, Ranjkesh B. Effect of white mineral trioxide aggregate mixed with disodium hydrogen phosphate on inflammatory cells. J Endod. 2009;35:703-5 pubmed publisher
    ..The aim of this study was subjective evaluation of inflammatory cells subsequent to subcutaneous implantation of white mineral trioxide aggregate (WMTA) mixed with disodium hydrogen phosphate (Na(2)HPO(4)) in rats...
  23. Gumienny T, MacNeil L, Wang H, de Bono M, Wrana J, Padgett R. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol. 2007;17:159-64 pubmed
    ..This is the first report of a glypican directly interacting with a growth-factor pathway in C. elegans and provides a mechanistic model for glypican regulation of growth-factor pathways...
  24. Yamanaka Y, Shigetani Y, Yoshiba K, Yoshiba N, Okiji T. Immunohistochemical analysis of subcutaneous tissue reactions to methacrylate resin-based root canal sealers. Int Endod J. 2011;44:669-75 pubmed publisher
    To investigate subcutaneous tissue reactions to methacrylate resin-based root canal sealers by immunohistochemical assessment of inflammatory/immunocompetent cell infiltration.
  25. Medawar P. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol. 1948;29:58-69 pubmed
  26. Kerner M, Ziv M, Abu Raya F, Horowitz E, Rozenman D. Subcutaneous sarcoidosis with neurological involvement: an unusual combination. Isr Med Assoc J. 2008;10:428-30 pubmed
  27. Garcia L, Marques A, Roselino L, Pires de Souza F, Consani S. Biocompatibility evaluation of Epiphany/Resilon root canal filling system in subcutaneous tissue of rats. J Endod. 2010;36:110-4 pubmed publisher
    ..The purpose of this study was to evaluate the biocompatibility of the root canal filling system Epiphany/Resilon in connective tissue of rats...
  28. Moussy Y, Hersh L, Dungel P. Distribution of [3H]dexamethasone in rat subcutaneous tissue after delivery from osmotic pumps. Biotechnol Prog. 2006;22:819-24 pubmed
    ..In the present study, we evaluated the distribution of dexamethasone in rat subcutaneous tissue during the first 2.5 days after local release...
  29. Scarparo R, Grecca F, Fachin E. Analysis of tissue reactions to methacrylate resin-based, epoxy resin-based, and zinc oxide-eugenol endodontic sealers. J Endod. 2009;35:229-32 pubmed publisher
    ..The only group to show a statistically significant reduction in inflammation during the 60-day period was the control group. None of the materials tested proved to have ideal characteristics for biocompatibility...
  30. Marcoval J, Moreno A, Mana J, Peyri J. Subcutaneous sarcoidosis. Dermatol Clin. 2008;26:553-6, ix pubmed publisher
    ..Histopathologically, sarcoidosis is characterized by noncaseating naked granulomas involving fat lobules, with minimal to no septal involvement...
  31. Gallardo F, Pujol R. Subcutaneous panniculitic-like T-cell lymphoma and other primary cutaneous lymphomas with prominent subcutaneous tissue involvement. Dermatol Clin. 2008;26:529-40, viii pubmed publisher
    ..a reduced group of primary cutaneous lymphomas characterized morphologically by a prominent or exclusive subcutaneous tissue involvement...
  32. Pantanowitz L, Mullen J, Dezube B. Primary Kaposi sarcoma of the subcutaneous tissue. World J Surg Oncol. 2008;6:94 pubmed publisher
    ..Primary KS of the subcutaneous tissue is an exceptional manifestation of this low-grade vascular neoplasm.
  33. Zambuzzi W, Oliveira R, Pereira F, Cestari T, Taga R, Granjeiro J. Rat subcutaneous tissue response to macrogranular porous anorganic bovine bone graft. Braz Dent J. 2006;17:274-8 pubmed
    ..was to evaluate the tissue response induced by bovine macrogranular porous anorganic bone implanted in rat subcutaneous tissue. Forty rats were assigned to 2 groups, as follows: the control group received empty collagen capsules and ..
  34. Fortna R, Junkins Hopkins J. A case of lobular capillary hemangioma (pyogenic granuloma), localized to the subcutaneous tissue, and a review of the literature. Am J Dermatopathol. 2007;29:408-11 pubmed
    ..The literature of lobular capillary hemangioma is reviewed, and the differential diagnosis is discussed...
  35. Reenalda J, Van Geffen P, Nederhand M, Jannink M, Ijzerman M, Rietman H. Analysis of healthy sitting behavior: interface pressure distribution and subcutaneous tissue oxygenation. J Rehabil Res Dev. 2009;46:577-86 pubmed
    ..behavior of 25 nondisabled male subjects by using a combination of interface pressure measurement and subcutaneous tissue oxygenation measurement by means of the Oxygen to See. These subjects shifted posture on average 7.8 +/- 5...
  36. Sato Y, Yokoyama A, Shibata K, Akimoto Y, Ogino S, Nodasaka Y, et al. Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. Mol Biosyst. 2005;1:176-82 pubmed
    ..the activation of the human acute monocytic leukemia cell line THP-1 in vitro and the response in subcutaneous tissue in vivo to CNTs of different lengths...
  37. Batista R, Hidalgo M, Hernandes L, Consolaro A, Velloso T, Cuman R, et al. Microscopic analysis of subcutaneous reactions to endodontic sealer implants in rats. J Biomed Mater Res A. 2007;81:171-7 pubmed
    ..These results reveal that the root canal sealers tested cause inflammation in rat, subcutaneous conjunctive tissue, the intensity of which may be related to the type and quantity of sealer used, and to postimplant period...
  38. de Campos Pinto M, de Oliveira D, Versiani M, Silva Sousa Y, de Sousa Neto M, da Cruz Perez D. Assessment of the biocompatibility of Epiphany root canal sealer in rat subcutaneous tissues. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:e77-81 pubmed publisher
    ..The aim of this study was to evaluate the biocompatibility of the root canal sealer Epiphany in rat subcutaneous tissues...
  39. Vosoughhosseini S, Lotfi M, Shahi S, Baloo H, Mesgariabbasi M, Saghiri M, et al. Influence of white versus gray mineral trioxide aggregate on inflammatory cells. J Endod. 2008;34:715-7 pubmed publisher
    ..tubes were filled with gray or white MTA and empty ones serving as the control group were implanted into subcutaneous tissue and harvested after 7-, 15-, 30-, 60-, and 90-day intervals...
  40. Roberts J, Kirkpatrick C, Roberts M, Robertson T, Dalley A, Lipman J. Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother. 2009;64:142-50 pubmed publisher
    To compare the plasma and subcutaneous tissue concentration-time profiles of meropenem administered by intermittent bolus dosing or continuous infusion to critically ill patients with sepsis and without renal dysfunction, and to use ..
  41. Agarwal C, Mendenhall S, Foreman K, Owsley J. The course of the frontal branch of the facial nerve in relation to fascial planes: an anatomic study. Plast Reconstr Surg. 2010;125:532-7 pubmed publisher
    ..The purpose of this study was to define the path of the frontal branches along fascial planes and to clarify the relationship of the fascial layers of the cheek and temporal region...
  42. Walsh H, Blazer V, Iwanowicz L, Smith G. A redescription of Myxobolus inornatus from young-of-the-year smallmouth bass (Micropterus dolomieu). J Parasitol. 2012;98:1236-42 pubmed publisher
    ..6-17.4) ?m in length and 8.6 ± 0.2 (range 7.1-13.7) ?m wide with an iodinophilous vacuole and a sutural ridge with 8 to 10 sutural folds. The SSU rDNA gene sequence places M. inornatus in a sister group with Myxobolus osburni ...
  43. Skorobogata O, Rocheleau C. RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE. 2012;7:e36489 pubmed publisher
    ..Failure to downregulate EGFR signaling contributes to oncogenesis, and thus Rab7 could possess tumor suppressor activity in humans...
  44. Ye F, Larsen S, Yaghmur A, Jensen H, Larsen C, Ostergaard J. Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging. J Pharm Biomed Anal. 2012;71:27-34 pubmed publisher
    ..method for real-time characterization of the release and transport of piroxicam in hydrogel-based subcutaneous tissue mimics/surrogates. Piroxicam partitioning from medium chain triglyceride (MCT) into 0...
  45. Rizzoni D, De Ciuceis C, Porteri E, Semeraro F, Rosei E. Structural alterations in small resistance arteries in obesity. Basic Clin Pharmacol Toxicol. 2012;110:56-62 pubmed publisher
    ..In obesity, a pronounced weight loss may improve microvascular structure. However, further studies are needed to elucidate the effects of other pharmacological and non-pharmacological interventions in obesity...
  46. Mitsuhashi A, Goto H, Kuramoto T, Tabata S, Yukishige S, Abe S, et al. Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages. Am J Pathol. 2013;182:1843-53 pubmed publisher
    ..Taking into account that SP-A did not directly activate NK cells, these results suggest that SP-A inhibited lung cancer progression by recruiting and activating NK cells via controlling the polarization of TAMs...
  47. Kasuga H, Fukuyama M, Kitazawa A, Kontani K, Katada T. The microRNA miR-235 couples blast-cell quiescence to the nutritional state. Nature. 2013;497:503-6 pubmed publisher
    ..Our findings establish a novel role of a miR-92 orthologue in coupling blast-cell behaviours to the nutritional state...
  48. Kjær S, Rud B, Bay Nielsen M. Ultrasound-guided drainage of subcutaneous abscesses on the trunk is feasible. Dan Med J. 2013;60:A4601 pubmed
    ..The aim of this study was to evaluate the feasibility of ultrasound-guided drainage combined with antibiotics in the treatment of subcutaneous abscesses on the trunk...
  49. Kostourou V, Lechertier T, Reynolds L, Lees D, Baker M, Jones D, et al. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun. 2013;4:2020 pubmed publisher
    ..Our results highlight a potential novel role for FAK as a nonlinear, dose-dependent regulator of angiogenesis where heterozygous levels of FAK enhance angiogenesis. ..
  50. Hoss U, Budiman E, Liu H, Christiansen M. Continuous glucose monitoring in the subcutaneous tissue over a 14-day sensor wear period. J Diabetes Sci Technol. 2013;7:1210-9 pubmed
    ..In this study, we evaluated the feasibility of a 14-day wear duration using a modified version of the sensor found in the Freestyle Navigator™ continuous glucose monitoring system...
  51. Yapucu Güneş U, Ceylan B, Bayindir P. Is the ventrogluteal site suitable for intramuscular injections in children under the age of three?. J Adv Nurs. 2016;72:127-34 pubmed publisher
  52. Babasola I, Bianco J, Amsden B. In vivo degradation and tissue response to poly(5-ethylene ketal ?-caprolactone-co-D,L-lactide). Biomacromolecules. 2012;13:2211-7 pubmed publisher
    ..These findings indicate that PEKCDLLA is a promising candidate for injectable drug delivery...
  53. Punke M, Decker C, Wodack K, Reuter D, Kluge S. Continuous glucose monitoring on the ICU using a subcutaneous sensor. Med Klin Intensivmed Notfmed. 2015;110:360-3 pubmed publisher
    ..sCGM monitoring via a subcutaneous sensor demonstrated high accuracy and considerable variability compared to blood gas samples, even in critically ill patients. ..