tissue adhesions


Summary: Pathological processes consisting of the union of the opposing surfaces of a wound.

Top Publications

  1. Parada Sanchez M, Chu E, Cox L, Undurty S, Standley J, Murray J, et al. Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. J Dent Res. 2017;96:1330-1338 pubmed publisher
    ..The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development. ..
  2. de Fonseka D, Edey A, Stadon L, Viner J, Darby M, Maskell N. The physiological consequences of different distributions of diffuse pleural thickening on CT imaging. Br J Radiol. 2017;90:20170218 pubmed publisher
    ..Advances in knowledge: Different distributions of DPT including no CPA obliteration can cause respiratory impairment, with bilateral DPT being the worst affected. ..
  3. Chaturvedi A, Yauw S, Lomme R, Hendriks T, van Goor H. Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis. Surg Infect (Larchmt). 2017;18:670-675 pubmed publisher
    ..Ultrapure alginate gel does not interfere with repair of ileal anastomoses constructed under conditions in which chances of anastomotic dehiscence are high. The alginate gel performs better than the HA/CMC film. ..
  4. Jiang C, Liu C, Guo J, Chen L, Luo N, Qu X, et al. CA125 modified by PLT and NLR improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion. Medicine (Baltimore). 2017;96:e6880 pubmed publisher
  5. Lafferty P, MacGregor F, Scobie W. Management of foreskin problems. Arch Dis Child. 1991;66:696-7 pubmed
    ..Despite the vogue for conservatism, circumcision still has an important part to play in the management of troublesome foreskins in children. ..
  6. Harlow C, Wu X, van Deemter M, Gardiner F, Poland C, Green R, et al. Targeting lysyl oxidase reduces peritoneal fibrosis. PLoS ONE. 2017;12:e0183013 pubmed publisher
    ..Progesterone significantly inhibited IL-1α induced Lox expression by PMC in vitro. Our results provide proof-of-concept that targeting peritoneal Lox could be an effective approach in ameliorating fibrosis and adhesion development. ..
  7. Xie P, Zheng X, Yu Y, Ye X, Hu Z, Yuan D, et al. Vitreomacular adhesion or vitreomacular traction may affect antivascular endothelium growth factor treatment for neovascular age-related macular degeneration. Br J Ophthalmol. 2017;101:1003-1010 pubmed publisher
    ..25 to 0.95), p=0.0008). In using anti-VEGF drugs to treat nAMD, clinicians should take into account the fact that concurrent VMA or VMT might antagonise the efficacy of anti-VEGF drugs during the early stage of treatment. ..
  8. Jing C. [Choice of the mode of laparoscopic right hemicolectomy]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:504-506 pubmed
    ..Surgeons should integrate their technical levels, hospital equipment, and conditions of patients, then choose reasonable operation mode of right hemicolectomy. ..
  9. Uluyol S. Effects of Silver Nitrate Cauterization on Middle Turbinate Synechia after Endoscopic Sinus Surgery. Otolaryngol Head Neck Surg. 2017;157:515-518 pubmed publisher
    ..001). Conclusion The results of this study suggest that silver nitrate cauterization of the MT is a practical and efficient method to eliminate middle meatal synechia after ESS. ..

More Information


  1. de Wilde R, Bakkum E, Brolmann H, Crowe A, Koninckx P, Korell M, et al. Consensus recommendations on adhesions (version 2014) for the ESGE Adhesions Research Working Group (European Society for Gynecological Endoscopy): an expert opinion. Arch Gynecol Obstet. 2014;290:581-2 pubmed publisher
    ..Thus present study concludes that topical application of daidzein reduces intra-articular adhesion around the knee. ..
  3. Jean R, O Neill K, Pei K, Davis K. Impact of hospital volume on outcomes for laparoscopic adhesiolysis for small bowel obstruction. J Surg Res. 2017;214:23-31 pubmed publisher
    ..017). This study demonstrates that high hospital volume was associated with decreased LOS for LLOA in SBO. Although volume was not associated with differences in total charges, there was a small decrease in hospital costs. ..
  4. Docherty J, McCormick P. A carboxymethylcellulose-heparin combination for the prevention of surgical adhesions. J Surg Res. 2017;213:228-233 pubmed publisher
    ..We suggest that this cheap and, as far as we know, safe intervention should be evaluated in human clinical trials. ..
  5. Bove G, Chapelle S, Hanlon K, Diamond M, Mokler D. Attenuation of postoperative adhesions using a modeled manual therapy. PLoS ONE. 2017;12:e0178407 pubmed publisher
    ..Our findings lay the groundwork for further research, including mechanical and pharmacologic approaches to maintain movements during healing. ..
  6. Bresson L, Leblanc E, Lemaire A, Okitsu T, Chai F. Autologous peritoneal grafts permit rapid reperitonealization and prevent postoperative abdominal adhesions in an experimental rat study. Surgery. 2017;162:863-870 pubmed publisher
  7. Kousa Y, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, et al. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017;96:1306-1313 pubmed publisher
  8. Giusto G, Vercelli C, Iussich S, Audisio A, Morello E, Odore R, et al. A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model. BMC Vet Res. 2017;13:55 pubmed publisher
    ..006, p?=?0.001, p?=?0.002, respectively). PHH is a novel absorbable barrier that is effective in preventing intra-abdominal adhesions in a cecal abrasion model in rats. ..
  9. Aydin O, Aydinuraz K, Agalar F, Sahiner I, Agalar C, Bayram C, et al. The effect of thymoquinone coating on adhesive properties of polypropylene mesh. BMC Surg. 2017;17:40 pubmed publisher
    ..067). TQ coated mesh is shown to reduce adhesion formation and TQ is a promising coating material for mesh surface modification. ..
  10. de Tribolet N, Porchet F, Lutz T, Gratzl O, Brotchi J, van Alphen H, et al. Clinical assessment of a novel antiadhesion barrier gel: prospective, randomized, multicenter, clinical trial of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms after lumbar discectomy. Am J Orthop (Belle Mead NJ). 1998;27:111-20 pubmed
    ..024 on the operative side and P = 0.015 on the nonoperative side), and ADCON-L reduced low back pain when it was most severe (P = 0.047) and at the end of the day (P = 0.044). ..
  11. Zerey M, Hawver L, Awad Z, Stefanidis D, Richardson W, Fanelli R. SAGES evidence-based guidelines for the laparoscopic resection of curable colon and rectal cancer. Surg Endosc. 2013;27:1-10 pubmed publisher
  12. Fredericks C, Kotry I, Holtz G, Askalani A, Serour G. Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. Am J Obstet Gynecol. 1986;155:667-70 pubmed
    ..97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety. ..
  13. Hillyer M, Mair T. Recurrent colic in the mature horse: a retrospective review of 58 cases. Equine Vet J. 1997;29:421-4 pubmed
    ..These included 3 cases of recurrent colonic impaction and 2 cases each of lymphosarcoma, 2 thromboembolic disease, 2 partial ileal obstructions and 2 intestinal adhesions. ..
  14. Uemura A, Nakata M, Goya S, Fukayama T, Tanaka R. Effective new membrane for preventing postthoracotomy pleural adhesion by surface water induction technology. PLoS ONE. 2017;12:e0179815 pubmed publisher
    ..Our novel anti-adhesive membrane appeared highly effective in preventing postthoracotomy pleural adhesions. ..
  15. Choi E, Yoo Y, Lee P, Kim Y, Lee S, Moon J. A Retrospective Study to Evaluate the Effect of Concentration of Hypertonic Saline on Efficacy and Safety of Epidural Adhesiolysis. Anesth Analg. 2017;124:2021-2029 pubmed publisher
    ..Further prospective randomized studies are required to better appreciate the outcome with regard to the use of different concentrations of hypertonic saline for PEA. ..
  16. Tuncal S, Kismet K, Kilicoglu B, Barlas A, Onalan A, Temel S, et al. Evaluation of intraabdominal adhesion generating potentials of ankaferd and calcium alginate used as hemostatic agents. Bratisl Lek Listy. 2014;115:544-9 pubmed
    ..The present study aimed to evaluate intra-abdominal adhesion generating potential of Ankaferd Blood Stopper (ABS), which was used as postoperative hemostatic agent in the rats that underwent surgery, in comparison with Ca-alginate...
  17. Vlasveld L, Taal B, Kroon B, Gallee M, Rodenhuis S. Intestinal obstruction due to diffuse peritoneal fibrosis at 2 years after the successful treatment of malignant peritoneal mesothelioma with intraperitoneal mitoxantrone. Cancer Chemother Pharmacol. 1992;29:405-8 pubmed
    ..However, laparotomy revealed extensive adhesive fibrosis but no sign of malignant mesothelioma. The peritoneal complications of intraperitoneal cytostatic treatment are discussed. ..
  18. Chen Y, Liu L, Luo Y, Chen M, Huan Y, Fang R. Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study. Biomed Res Int. 2017;2017:8526104 pubmed publisher
  19. Yang K, Yu C, Lee J, Kim C, Yoon Y, Park I, et al. The long-term outcomes of recurrent adhesive small bowel obstruction after colorectal cancer surgery favor surgical management. Medicine (Baltimore). 2017;96:e8316 pubmed publisher
    ..Operative management should be considered for recurrent SBO. ..
  20. Tan Y, Wu Q, Wu Q, Tan X, Chen L, Wang X. Thermal Preconditioning May Prevent Tendon Adhesion by Up-Regulating HSP72 in Rats. Cell Physiol Biochem. 2017;42:1623-1634 pubmed publisher
    ..These findings provide evidence that thermal preconditioning may alleviate tendon adhesions via upregulation of HSP72 expression. ..
  21. Mec Słomska A, Adamiec Mroczek J, Kuźmicz E, Misiuk Hojło M. Intravitreal ocriplasmin: A breakthrough in the treatment of vitreomacular traction?. Adv Clin Exp Med. 2017;26:527-531 pubmed publisher
    ..We reviewed the results of recent studies comparing ocriplasmin to other widespread treatment options, such as pars plana vitrectomy. ..
  22. Khorshidi H, Kasraianfard A, Derakhshanfar A, Rahimi S, Sharifi A, Makarchian H, et al. Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study. Acta Cir Bras. 2017;32:626-632 pubmed publisher
    ..Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation. ..
  23. De Groef A, Van Kampen M, Vervloesem N, De Geyter S, Dieltjens E, Christiaens M, et al. An evaluation tool for myofascial adhesions in patients after breast cancer (MAP-BC evaluation tool): Development and interrater reliability. PLoS ONE. 2017;12:e0179116 pubmed publisher
    ..71). The total scores of all locations of the MAP-BC evaluation tool had good to excellent interrater reliability, except for the inframammary fold which only reached moderate reliability. ..
  24. Behman R, Nathens A, Byrne J, Mason S, Look Hong N, Karanicolas P. Laparoscopic Surgery for Adhesive Small Bowel Obstruction Is Associated With a Higher Risk of Bowel Injury: A Population-based Analysis of 8584 Patients. Ann Surg. 2017;266:489-498 pubmed publisher
    ..We set out to compare the incidence of bowel repair and/or resection in a large cohort of patients with adhesive small bowel obstruction (SBO) managed operatively...
  25. Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, et al. SOGC clinical practice guidelines: Adhesion prevention in gynaecological surgery: no. 243, June 2010. Int J Gynaecol Obstet. 2010;111:193-7 pubmed
    ..The quality of evidence was rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care. ..
  26. Uçar M, Sanlikan F, Ilhan T, Gocmen A, Celik C. Management of intra-abdominally translocated contraceptive devices, is surgery the only way to treat this problem?. J Obstet Gynaecol. 2017;37:480-486 pubmed publisher
  27. Wong Y, Smith R, Koppenhaver S. Soft Tissue Mobilization to Resolve Chronic Pain and Dysfunction Associated With Postoperative Abdominal and Pelvic Adhesions: A Case Report. J Orthop Sports Phys Ther. 2015;45:1006-16 pubmed publisher
    ..Studies with a higher level of evidence, including potential comparison between STM and traditional laparoscopic adhesiolysis, are needed to further determine benefits of nonsurgical care for this condition. ..
  28. Barbul A. In brief. Abdominal adhesions. Curr Probl Surg. 2015;52:266-9 pubmed publisher
  29. Hooker A, de Leeuw R, van de Ven P, Bakkum E, Thurkow A, Vogel N, et al. Prevalence of intrauterine adhesions after the application of hyaluronic acid gel after dilatation and curettage in women with at least one previous curettage: short-term outcomes of a multicenter, prospective randomized controlled trial. Fertil Steril. 2017;107:1223-1231.e3 pubmed publisher
    ..Future studies are needed to confirm our findings and to evaluate the effect of ACP gel on fertility and reproductive outcomes. NTR 3120. ..
  30. Beyene R, Kavalukas S, Barbul A. Intra-abdominal adhesions: Anatomy, physiology, pathophysiology, and treatment. Curr Probl Surg. 2015;52:271-319 pubmed publisher