elastic tissue

Summary

Summary: Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.

Top Publications

  1. Yeo G, Baldock C, Tuukkanen A, Roessle M, Dyksterhuis L, Wise S, et al. Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly. Proc Natl Acad Sci U S A. 2012;109:2878-83 pubmed publisher
    ..This increased flexibility of the R515A mutant suggests that the tropoelastin R515 residue stabilizes the structure of the bridge region, which is critical for elastic fiber assembly...
  2. Wang A, Lewis K, Lewis M, Robinson Bostom L. Papillary dermal elastosis: a unique elastic tissue disorder or an unusual manifestation of pseudoxanthoma elasticum-like papillary dermal elastolysis?. J Cutan Pathol. 2009;36:1010-3 pubmed publisher
    There are numerous acquired elastic tissue disorders, several of which present cutaneously with small yellow-to-white papules resembling plucked chicken skin...
  3. Rahn D, Acevedo J, Roshanravan S, Keller P, Davis E, Marmorstein L, et al. Failure of pelvic organ support in mice deficient in fibulin-3. Am J Pathol. 2009;174:206-15 pubmed publisher
    ..We suggest that increased vaginal protease activity and abnormal elastic fibers in the vaginal wall are important components in the pathogenesis of pelvic organ prolapse...
  4. Ribeiro M, Kneubil M, Aquino M, Gomes G, Mazzilli P, Buffolo E, et al. [Histomorphometric differences between the left and right internal thoracic arteries in humans]. Rev Bras Cir Cardiovasc. 2008;23:1-6 pubmed
    ..Therefore the aim of this study was to examine and compare the histomorphometric structure among different segments of the left and right ITA...
  5. Pugashetti R, Shinkai K, Ruben B, Grossman M, Maldonado J, Fox L. Calcium may preferentially deposit in areas of elastic tissue damage. J Am Acad Dermatol. 2011;64:296-301 pubmed publisher
    ..Cutaneous calcification is an acquired disorder whereby insoluble, amorphous calcium salts deposit in the skin. Classically, cutaneous calcification is categorized as metastatic, dystrophic, idiopathic, or iatrogenic...
  6. Sherratt M. Tissue elasticity and the ageing elastic fibre. Age (Dordr). 2009;31:305-25 pubmed publisher
    ..As compromised elasticity is a common feature of ageing dynamic tissues, the development of strategies to prevent, limit or reverse this loss of function will play a key role in reducing age-related morbidity and mortality...
  7. Maina J, Jimoh S, Hosie M. Implicit mechanistic role of the collagen, smooth muscle, and elastic tissue components in strengthening the air and blood capillaries of the avian lung. J Anat. 2010;217:597-608 pubmed publisher
    ..circumference, the atrial and the infundibular CF are directly connected to the smooth muscle fibers and the elastic tissue fibers...
  8. Renard M, Holm T, Veith R, Callewaert B, Ades L, Baspinar O, et al. Altered TGFbeta signaling and cardiovascular manifestations in patients with autosomal recessive cutis laxa type I caused by fibulin-4 deficiency. Eur J Hum Genet. 2010;18:895-901 pubmed publisher
    ..This confirms the important role of fibulin-4 in vascular elastic fiber assembly. Furthermore, we provide the first evidence for the involvement of altered TGFbeta signaling in the pathogenesis of FBLN4 mutations in humans...
  9. Choi J, Bergdahl A, Zheng Q, Starcher B, Yanagisawa H, Davis E. Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly. Matrix Biol. 2009;28:211-20 pubmed publisher

More Information

Publications62

  1. Osborne Pellegrin M, Labat C, Mercier N, Challande P, Lacolley P. Changes in aortic stiffness related to elastic fiber network anomalies in the Brown Norway rat during maturation and aging. Am J Physiol Heart Circ Physiol. 2010;299:H144-52 pubmed publisher
    ..Thereafter, age-related AA stiffness increased less in BN than in LE, likely due to the numerous IEL ruptures. We conclude that, in the BN rat, the lower E/C and the presence of IEL ruptures have opposing effects on arterial stiffness...
  2. Huang J, Davis E, Chapman S, Budatha M, Marmorstein L, Word R, et al. Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res. 2010;106:583-92 pubmed publisher
    ..However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which absence also leads to compromised elastic fibers...
  3. Chen Q, Zhang T, Roshetsky J, Ouyang Z, Essers J, Fan C, et al. Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts. Biochem J. 2009;423:79-89 pubmed publisher
    ..These results indicate that fibulin-4, considered as a structural protein, may also participate in regulating elastic-fibre formation in human cells through an unanticipated mechanism, namely the regulation of tropoelastin expression...
  4. Choudhury R, McGovern A, Ridley C, Cain S, Baldwin A, Wang M, et al. Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem. 2009;284:24553-67 pubmed publisher
    ..These experiments provide a molecular account of the distinct roles of fibulin-4 and -5 in elastic fiber assembly and how they act in concert to chaperone cross-linked elastin onto microfibrils...
  5. Hu Q, Loeys B, Coucke P, De Paepe A, Mecham R, Choi J, et al. Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Hum Mol Genet. 2006;15:3379-86 pubmed
    ..These findings support the hypothesis that fibulin-5 is necessary for elastic fiber formation by facilitating the deposition of elastin onto a microfibrillar scaffold via direct molecular interactions...
  6. Gheduzzi D, Boraldi F, Annovi G, DeVincenzi C, Schurgers L, Vermeer C, et al. Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. Lab Invest. 2007;87:998-1008 pubmed
    ..The lower ratio of Gla-MGP over Glu-MGP in pathological fibroblasts compared to controls suggests these cells may play an important role in the ectopic calcification in PXE...
  7. Sicot F, Tsuda T, Markova D, Klement J, Arita M, Zhang R, et al. Fibulin-2 is dispensable for mouse development and elastic fiber formation. Mol Cell Biol. 2008;28:1061-7 pubmed
    ..The results demonstrate that fibulin-2 is not required for mouse development and elastic fiber formation and suggest possible functional redundancy between fibulin-1 and fibulin-2...
  8. Niederhoffer N, Lartaud Idjouadiene I, Giummelly P, Duvivier C, Peslin R, Atkinson J. Calcification of medial elastic fibers and aortic elasticity. Hypertension. 1997;29:999-1006 pubmed
    ..In conclusion, elastocalcinosis induces destruction of elastic fibers, which leads to arterial stiffness, and the latter may be involved in the development of left ventricular hypertrophy in a normotensive model...
  9. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer J, et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004;36:178-82 pubmed
    ..Thus elastin polymer deposition is a crucial aspect of elastic fiber maintenance and is dependent on LOXL1, which serves both as a cross-linking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin...
  10. Yu H, Liu X, Kiss S, Connolly E, Gragoudas E, Michaud N, et al. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci. 2008;49:2599-605 pubmed publisher
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  11. Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien K, et al. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol. 2007;176:1061-71 pubmed
    ..These data suggest that fibulin-5 could be a novel therapeutic target for elastic fiber regeneration...
  12. Yanagisawa H, Davis E, Starcher B, Ouchi T, Yanagisawa M, Richardson J, et al. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002;415:168-71 pubmed
    ..This function may be mediated by the RGD motif in fibulin-5, which binds to cell surface integrins, and the Ca2+-binding epidermal growth factor (EGF) repeats, which bind elastin...
  13. Arribas S, Hinek A, Gonzalez M. Elastic fibres and vascular structure in hypertension. Pharmacol Ther. 2006;111:771-91 pubmed
    ..In this paper, we review current knowledge regarding components of elastic fibres and discuss their possible pathomechanistic associations with vascular structural abnormalities and with hypertension development or progression...
  14. O BRIEN J, Regan W. Actinically degenerate elastic tissue is the likely antigenic basis of actinic granuloma of the skin and of temporal arteritis. J Am Acad Dermatol. 1999;40:214-22 pubmed
    ..a selective "controlled" hematoxylin-and-eosin stain, actinically damaged ("elastotic") elastic tissue stains blue, as Unna described, and contrasts with normal and simply hyperplastic elastic tissue, which stains ..
  15. Hanssen E, Hew F, Moore E, Gibson M. MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. J Biol Chem. 2004;279:29185-94 pubmed
  16. Lewis K, Bercovitch L, Dill S, Robinson Bostom L. Acquired disorders of elastic tissue: Part II. decreased elastic tissue. J Am Acad Dermatol. 2004;51:165-85; quiz 186-8 pubmed
    ..and elasticity required for normal structure and function of the skin are attributable to the network of elastic tissue. Advances in our understanding of elastic tissue physiology provide a foundation for studying the pathogenesis ..
  17. Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien K, Nakamura T. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J. 2007;26:3283-95 pubmed
    ..These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers...
  18. Zheng Q, Davis E, Richardson J, Starcher B, Li T, Gerard R, et al. Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers. Mol Cell Biol. 2007;27:1083-95 pubmed
    ..These results also support the potential use of fibulin-5 as a therapeutic agent for the treatment of elastinopathies...
  19. Zweers M, van Vlijmen Willems I, van Kuppevelt T, Mecham R, Steijlen P, Bristow J, et al. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol. 2004;122:885-91 pubmed
    ..These findings suggest that both elastic fiber abnormalities and reduced collagen content contribute to the observed phenotype in TNX-deficient patients...
  20. Habashi J, Judge D, Holm T, Cohn R, Loeys B, Cooper T, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006;312:117-21 pubmed
  21. Le Saux O, Bunda S, VanWart C, Douet V, Got L, Martin L, et al. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006;126:1497-505 pubmed
    ..These results indicated that certain metabolites present in PXE sera interfered with the normal assembly of elastic fibers in vitro and suggested that PXE is a primary metabolic disorder with secondary connective tissue manifestations...
  22. Hu Q, Reymond J, Pinel N, Zabot M, Urban Z. Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. J Invest Dermatol. 2006;126:283-90 pubmed
    ..These results suggest that the pathogenesis of acquired CL involves an underlying genetic susceptibility and highlight the importance of molecular genetic analysis in patients with idiopathic connective tissue disorders...
  23. Aessopos A, Farmakis D, Loukopoulos D. Elastic tissue abnormalities in inherited haemolytic syndromes. Eur J Clin Invest. 2002;32:640-2 pubmed
  24. Jones G, Harris E, Jacob H, van Rij A. Spontaneous elastic tissue lesions in the rat abdominal aorta, a genetically determined phenotype. J Vasc Res. 2000;37:73-81 pubmed
    ..All BN aortae contained numerous elastic tissue defects. In comparison, GH aortae contained only occasional elastic tissue lesions...
  25. Trask B, Trask T, Broekelmann T, Mecham R. The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. Mol Biol Cell. 2000;11:1499-507 pubmed
    ..Sulfation of matrix proteins is important for elastic fiber assembly because inhibition of sulfation was shown to prevent microfibrillar protein incorporation into the extracellular matrix of cultured cells...
  26. Mauad T, Xavier A, Saldiva P, Dolhnikoff M. Elastosis and fragmentation of fibers of the elastic system in fatal asthma. Am J Respir Crit Care Med. 1999;160:968-75 pubmed
    ..We also suggest that disrupture of fiber attachments at the basement membrane in the superficial layer could impair the mechanism of airway recoil in asthmatic patients...
  27. Aessopos A, Farmakis D, Loukopoulos D. Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes. Blood. 2002;99:30-5 pubmed
    The development of clinical and histopathologic manifestations of a diffuse elastic tissue defect, resembling inherited pseudoxanthoma elasticum (PXE), has been encountered with a notable frequency in patients with beta thalassemia, ..
  28. Just M, Ribera M, Monso E, Lorenzo J, Ferrandiz C. Effect of smoking on skin elastic fibres: morphometric and immunohistochemical analysis. Br J Dermatol. 2007;156:85-91 pubmed
    ..The underlying mechanism is not well known, but elastic fibres of the dermis seem to be the major target of smoke components...
  29. Cain S, Raynal B, Hodson N, Shuttleworth A, Kielty C. Biomolecular analysis of elastic fibre molecules. Methods. 2008;45:42-52 pubmed publisher
    ..Data from these in vitro analytical approaches can be combined to develop powerful new models of elastic fibre assembly...
  30. Kielty C, Stephan S, Sherratt M, Williamson M, Shuttleworth C. Applying elastic fibre biology in vascular tissue engineering. Philos Trans R Soc Lond B Biol Sci. 2007;362:1293-312 pubmed
    ..This review addresses physiological elastic fibre assembly and contributions to vessel structure and function, and how elastic fibre biology is now being exploited in small diameter vascular graft design...
  31. Alvarez Cuesta C, Raya Aguado C, Fernández Rippe M, Sánchez T, Perez Oliva N. Anetoderma in a systemic lupus erythematosus patient with anti-PCNA and antiphospholipid antibodies. Dermatology. 2001;203:348-50 pubmed
    ..We present a case of anetoderma in a systemic lupus erythematosus patient with anti-proliferating-cell-nuclear-antigen and antiphospholipid antibodies, highlighting the peculiarities of such an association...
  32. McLaughlin P, Bakall B, Choi J, Liu Z, Sasaki T, Davis E, et al. Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice. Hum Mol Genet. 2007;16:3059-70 pubmed
    ..These data demonstrate that fibulin-3 plays an important role in maintaining the integrity of fascia connective tissues and regulates aging...
  33. Dasouki M, Markova D, Garola R, Sasaki T, Charbonneau N, Sakai L, et al. Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa. Am J Med Genet A. 2007;143A:2635-41 pubmed
    Mutations involving elastic tissue proteins result in a broad spectrum of phenotypes affecting skin, skeleton, ocular and vascular structures, including tortuous blood vessels and cutis laxa...
  34. Starcher B, Aycock R, Hill C. Multiple roles for elastic fibers in the skin. J Histochem Cytochem. 2005;53:431-43 pubmed
    ..The data suggest that the primary role for elastic fibers in animals, with the possible exception of humans, is movement and/or placement of feathers or hair...
  35. Argraves W, Greene L, Cooley M, Gallagher W. Fibulins: physiological and disease perspectives. EMBO Rep. 2003;4:1127-31 pubmed
  36. Nakamura T, Lozano P, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, et al. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002;415:171-5 pubmed
    ..Thus, fibulin-5 may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibres in the skin, lung and vasculature...
  37. Zanetti M, Braghetta P, Sabatelli P, Mura I, Doliana R, Colombatti A, et al. EMILIN-1 deficiency induces elastogenesis and vascular cell defects. Mol Cell Biol. 2004;24:638-50 pubmed
  38. Thibeault D, Mabry S, Ekekezie I, Truog W. Lung elastic tissue maturation and perturbations during the evolution of chronic lung disease. Pediatrics. 2000;106:1452-9 pubmed
    ..Our aims were to quantitate parenchymal elastic tissue during normal fetal development and in infants born at 23 to 30 weeks' gestation with prolonged survival at ..
  39. Faury G. Function-structure relationship of elastic arteries in evolution: from microfibrils to elastin and elastic fibres. Pathol Biol (Paris). 2001;49:310-25 pubmed
    ..Elastin would then be deposited on microfibrils and resulting in the elastic fibre network and elastic lamellae whose mechanical properties are adapted to allow for proper arterial work at higher pressures...
  40. Ghomrasseni S, Dridi M, Gogly B, Bonnefoix M, Vabres P, Venencie P, et al. Anetoderma: an altered balance between metalloproteinases and tissue inhibitors of metalloproteinases. Am J Dermatopathol. 2002;24:118-29 pubmed
    ..Because MMP-3, MMP-7, MMP-9 are known to degrade elastin, and MMP-3 can activate the latent forms of MMP-7 and MMP-9, we propose that these metalloproteinases also participate in the degradation of elastic fibers in anetodermic skin...
  41. Clarke A, Wise S, Cain S, Kielty C, Weiss A. Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin. Biochemistry. 2005;44:10271-81 pubmed
    ..This study underscores the role of this part of fibrillin-1 as an anchor point for tropoelastin at the microfibril-elastin junction during the initial stages of elastic fiber assembly...
  42. Kielty C, Sherratt M, Shuttleworth C. Elastic fibres. J Cell Sci. 2002;115:2817-28 pubmed
    ..However, their molecular complexity is at last being unravelled by progress in identifying interactions between component molecules, ultrastructural analyses and studies of informative mouse models...
  43. Ross J, McIntire L, Moake J, Kuo H, Qian R, Glanville R, et al. Fibrillin containing elastic microfibrils support platelet adhesion under dynamic shear conditions. Thromb Haemost. 1998;79:155-61 pubmed
    ..These results suggest roles for both collagen VI and fibrillin containing elastic microfibrils in modulating the platelet response to blood vessel injury...
  44. Pascoe K, Wlodek M, Jones G. Increased elastic tissue defect formation in the growth restricted Brown Norway rat: a potential link between in utero condition and cardiovascular disease. Pediatr Res. 2008;64:125-30 pubmed publisher
    ..to support the fetal origins of adult disease hypothesis, by demonstrating that a moderate growth restricting insult dramatically increases aortic elastic tissue defect formation via an apparently blood pressure-independent mechanism.
  45. Wagenseil J, Mecham R. New insights into elastic fiber assembly. Birth Defects Res C Embryo Today. 2007;81:229-40 pubmed publisher
  46. Kielty C. Elastic fibres in health and disease. Expert Rev Mol Med. 2006;8:1-23 pubmed
  47. Wachi H, Sato F, Murata H, Nakazawa J, Starcher B, Seyama Y. Development of a new in vitro model of elastic fiber assembly in human pigmented epithelial cells. Clin Biochem. 2005;38:643-53 pubmed
    ..We developed an in vitro model of elastic fiber assembly that provides a comparison of the efficiency of different tropoelastin molecules to organize into fibers...
  48. Rock M, Cain S, Freeman L, Morgan A, Mellody K, Marson A, et al. Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link. J Biol Chem. 2004;279:23748-58 pubmed
    ..Microfibril-associated glycoprotein-1 thus contributes to microfibril organization but may also form secondary interactions with adjacent microfibril-bound tropoelastin...
  49. Wulf H, Sandby Møller J, Kobayasi T, Gniadecki R. Skin aging and natural photoprotection. Micron. 2004;35:185-91 pubmed
    ..The minimal erythema dose is thus the same through life, when corrected for pigmentation or measured in areas with constitutive pigmentation...
  50. Pastor L, Sánchez Gascón F, Girona J, Bernal Mañas C, Morales E, Beltrán Frutos E, et al. Morphogenesis of rat experimental pulmonary emphysema induced by intratracheally administered papain: changes in elastic fibres. Histol Histopathol. 2006;21:1309-19 pubmed publisher
    ..The results seem to point to a very abnormal remodelling process associated with elastic fibre regeneration, although there were no signs of destruction of these new fibres formed in emphysematous rat lung induced by papain...
  51. McLaughlin P, Chen Q, Horiguchi M, Starcher B, Stanton J, Broekelmann T, et al. Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol. 2006;26:1700-9 pubmed
    ..In addition, fibulin-4 strongly interacts with tropoelastin and colocalizes with elastic fibers in culture. These results demonstrate that fibulin-4 plays an irreplaceable role in elastogenesis...
  52. Lewis K, Bercovitch L, Dill S, Robinson Bostom L. Acquired disorders of elastic tissue: part I. Increased elastic tissue and solar elastotic syndromes. J Am Acad Dermatol. 2004;51:1-21; quiz 22-4 pubmed
    ..and elasticity required for normal structure and function of the skin may be attributed to the network of elastic tissue. Advances in our understanding of elastic tissue physiology provide a foundation for studying the pathogenesis ..
  53. Revelles J, Machan S, Pielasinski U, Camacho D, Vallés L, Santonja C, et al. Pseudoxanthoma elasticum-like papillary dermal elastolysis: immunohistochemical study using elastic fiber cross-reactivity with an antibody against amyloid P component. Am J Dermatopathol. 2012;34:637-43 pubmed publisher
    ..We report 2 cases of PXE-like papillary dermal elastolysis, in which the anomalies of the elastic tissue were immunohistochemically investigated with an antibody to the amyloid P component...