Summary: The outermost covering of organs, blood vessels, and other such structures in the body.

Top Publications

  1. Mulligan Kehoe M, Simons M. Vasa vasorum in normal and diseased arteries. Circulation. 2014;129:2557-66 pubmed publisher
  2. Majesky M. Adventitia and perivascular cells. Arterioscler Thromb Vasc Biol. 2015;35:e31-5 pubmed publisher
  3. Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, et al. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017;37:1698-1709 pubmed publisher
    ..These effects were abolished in CYLD-/- mice. CYLD contributes to the transdifferentiation of AFs via deubiquitinating Nox4 and may play a role in vascular remodeling. ..
  4. Hennessy M, McGreal G, O Brien G. Two Cases of Popliteal Cystic Adventitial Disease Treated With Excision and Primary Bypass Graft: A Review of the Literature. Vasc Endovascular Surg. 2017;51:480-484 pubmed publisher
    ..We analyzed all literature published on CAD since first reported in 1947 and we propose an algorithm for appropriate management pathways. ..
  5. Meijles D, Pagano P. Nox and Inflammation in the Vascular Adventitia. Hypertension. 2016;67:14-9 pubmed publisher
  6. Son J, Choi Y. Reconstruction of Intima and Adventitia Models into a State Undeformed by a Catheter by Using CT, IVUS, and Biplane X-Ray Angiogram Images. Comput Math Methods Med. 2017;2017:9807617 pubmed publisher
    ..Though a 3D blood vessel model that includes intima and adventitia is required for FSI analysis, there are difficulties in generating it using only one type of medical imaging...
  7. Hou Y, Liu W, Zheng C, Zheng J, Yen T, Lu K. Role of Vitamin D in Uremic Vascular Calcification. Biomed Res Int. 2017;2017:2803579 pubmed publisher
    ..Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification. ..
  8. Ren X, Ma J, Zeng C, Sun Y, Lin S. Ultrastructure of Pericystic or Intracystic Blood Vessels in Epidermoid Cysts-A Transmission Electron Microscopy Study: Laboratory Investigation. World Neurosurg. 2017;103:484-492 pubmed publisher
    ..In the tunicae media, vacuolization and swollen mitochondria were found in muscular cells. In the tunicae adventitia, extravascular erythrocytes, edema or apoptosis of pericytes, collagen predominance, and inflammatory cell ..
  9. Neven K, van Es R, van Driel V, van Wessel H, Fidder H, Vink A, et al. Acute and Long-Term Effects of Full-Power Electroporation Ablation Directly on the Porcine Esophagus. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
    ..cathodal 100 and 200 J applications were delivered at 2 different sites on the anterior esophageal adventitia. No proton-pump inhibitors were administered during follow-up. Esophagoscopy was performed at days 2 and 7...

More Information


  1. Kuwabara J, Tallquist M. Tracking Adventitial Fibroblast Contribution to Disease: A Review of Current Methods to Identify Resident Fibroblasts. Arterioscler Thromb Vasc Biol. 2017;37:1598-1607 pubmed publisher
    Cells present in the adventitia, or outermost layer of the blood vessel, contribute to the progression of vascular diseases, such as atherosclerosis, hypertension, and aortic dissection...
  2. Angelov S, Hu J, Wei H, Airhart N, Shi M, Dichek D. TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms. Arterioscler Thromb Vasc Biol. 2017;37:2102-2113 pubmed publisher
    ..Smooth muscle extrinsic signaling protects the abdominal aorta and smooth muscle intrinsic signaling protects the thoracic aorta. ..
  3. Nishimiya K, Matsumoto Y, Takahashi J, Uzuka H, Odaka Y, Nihei T, et al. In vivo visualization of adventitial vasa vasorum of the human coronary artery on optical frequency domain imaging. Validation study. Circ J. 2014;78:2516-8 pubmed